APITD1-CORT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.56046135
2CENP-A containing nucleosome assembly (GO:0034080)5.55929355
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.53311392
4chaperone-mediated protein transport (GO:0072321)5.24021866
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.86723546
6ATP synthesis coupled proton transport (GO:0015986)4.86723546
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.67579916
8histone exchange (GO:0043486)4.55209193
9proteasome assembly (GO:0043248)4.50724252
10DNA replication-independent nucleosome organization (GO:0034724)4.31340662
11DNA replication-independent nucleosome assembly (GO:0006336)4.31340662
12pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.27809948
13DNA strand elongation involved in DNA replication (GO:0006271)4.25262158
14telomere maintenance via semi-conservative replication (GO:0032201)4.21019965
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.20415308
16kinetochore organization (GO:0051383)4.19077356
17DNA strand elongation (GO:0022616)4.07004265
18protein complex biogenesis (GO:0070271)4.00013589
19centriole replication (GO:0007099)3.99267694
20respiratory electron transport chain (GO:0022904)3.97630348
21regulation of mitochondrial translation (GO:0070129)3.97146105
22kinetochore assembly (GO:0051382)3.96292550
23ribosomal small subunit assembly (GO:0000028)3.95333535
24protein neddylation (GO:0045116)3.94634896
25electron transport chain (GO:0022900)3.88967937
26mitochondrial respiratory chain complex assembly (GO:0033108)3.84468147
27DNA replication checkpoint (GO:0000076)3.83484791
28maturation of SSU-rRNA (GO:0030490)3.81957687
29pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.77709016
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70708267
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.70708267
32NADH dehydrogenase complex assembly (GO:0010257)3.70708267
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66623947
34resolution of meiotic recombination intermediates (GO:0000712)3.66237476
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65102403
36replication fork processing (GO:0031297)3.64973307
37mitotic metaphase plate congression (GO:0007080)3.64669538
38protein localization to kinetochore (GO:0034501)3.62877401
39telomere maintenance via recombination (GO:0000722)3.62010150
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60546084
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.58962581
42mitotic recombination (GO:0006312)3.54519893
43termination of RNA polymerase III transcription (GO:0006386)3.54332541
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.54332541
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48301681
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.44635782
47DNA ligation (GO:0006266)3.42196984
48establishment of integrated proviral latency (GO:0075713)3.41911260
49regulation of double-strand break repair via homologous recombination (GO:0010569)3.41401249
50pyrimidine nucleotide catabolic process (GO:0006244)3.41373599
51ribosomal small subunit biogenesis (GO:0042274)3.38213417
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34825853
53base-excision repair, AP site formation (GO:0006285)3.32238377
54translational termination (GO:0006415)3.28952400
55negative regulation of ligase activity (GO:0051352)3.28836761
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28836761
57viral transcription (GO:0019083)3.28410348
58metaphase plate congression (GO:0051310)3.28195856
59spliceosomal snRNP assembly (GO:0000387)3.25804935
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21168477
61transcription-coupled nucleotide-excision repair (GO:0006283)3.19240566
62regulation of meiosis I (GO:0060631)3.17430402
63protein localization to chromosome, centromeric region (GO:0071459)3.15211925
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10507526
65cullin deneddylation (GO:0010388)3.07255916
66protein-cofactor linkage (GO:0018065)3.05346974
67rRNA modification (GO:0000154)3.05241119
68establishment of chromosome localization (GO:0051303)3.03005407
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02343766
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01784778
71regulation of mitotic spindle checkpoint (GO:1903504)3.01784778
72telomere maintenance via telomere lengthening (GO:0010833)3.01661899
73deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.00959703
74cotranslational protein targeting to membrane (GO:0006613)3.00561215
75DNA replication-dependent nucleosome organization (GO:0034723)3.00118181
76DNA replication-dependent nucleosome assembly (GO:0006335)3.00118181
77DNA damage response, detection of DNA damage (GO:0042769)2.99348016
78chromatin assembly or disassembly (GO:0006333)2.98816676
79DNA double-strand break processing (GO:0000729)2.96401539
80protein deneddylation (GO:0000338)2.94533696
81translesion synthesis (GO:0019985)2.94428148
82regulation of cellular amino acid metabolic process (GO:0006521)2.93372628
83protein targeting to mitochondrion (GO:0006626)2.92779316
84protein targeting to ER (GO:0045047)2.92765495
85base-excision repair (GO:0006284)2.87179854
86regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86429421
87histone mRNA metabolic process (GO:0008334)2.85496076
88DNA catabolic process, exonucleolytic (GO:0000738)2.84803846
89synapsis (GO:0007129)2.84079983
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84009523
91pseudouridine synthesis (GO:0001522)2.83630231
92purine nucleobase biosynthetic process (GO:0009113)2.81321249
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81121766
94centriole assembly (GO:0098534)2.80470596
95establishment of viral latency (GO:0019043)2.80104977
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.79322291
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78958227
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78958227
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78958227
100ATP-dependent chromatin remodeling (GO:0043044)2.77616593

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23276081
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.97391685
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.99770623
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.99729404
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.99693369
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.86479900
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.32008861
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.30337462
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.29365418
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24082157
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11609034
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.09015352
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.90077574
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88807762
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.86918869
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.82211705
17EZH2_22144423_ChIP-Seq_EOC_Human2.49072072
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40066991
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38111783
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32103197
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27841326
22ELK1_19687146_ChIP-ChIP_HELA_Human2.25680582
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24013408
24VDR_23849224_ChIP-Seq_CD4+_Human2.23725707
25FOXP3_21729870_ChIP-Seq_TREG_Human2.17022608
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.10788021
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02552773
28TTF2_22483619_ChIP-Seq_HELA_Human1.90007892
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89963165
30DCP1A_22483619_ChIP-Seq_HELA_Human1.88110291
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81994241
32GABP_19822575_ChIP-Seq_HepG2_Human1.79860844
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78323672
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.76654387
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.73587847
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71135992
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70459196
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.68409101
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68076330
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67520011
41AR_21909140_ChIP-Seq_LNCAP_Human1.63729901
42MYC_18940864_ChIP-ChIP_HL60_Human1.63484745
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62755019
44XRN2_22483619_ChIP-Seq_HELA_Human1.61772689
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59336565
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53868676
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50147322
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48570797
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47213184
50EWS_26573619_Chip-Seq_HEK293_Human1.45653995
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44879669
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42422174
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40786681
54ZNF274_21170338_ChIP-Seq_K562_Hela1.39007739
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33138008
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33036918
57VDR_22108803_ChIP-Seq_LS180_Human1.31897114
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31013953
59IRF1_19129219_ChIP-ChIP_H3396_Human1.29249106
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27054096
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24578485
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22754278
63FUS_26573619_Chip-Seq_HEK293_Human1.18452539
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.14054728
65ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12680173
66E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11608636
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.08652407
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08188131
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07863109
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01227804
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00727096
72KDM5A_27292631_Chip-Seq_BREAST_Human1.00535844
73SOX2_16153702_ChIP-ChIP_HESCs_Human0.99074986
74NANOG_16153702_ChIP-ChIP_HESCs_Human0.96393720
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92738451
76TP53_22573176_ChIP-Seq_HFKS_Human0.91040718
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.88494233
78ELK1_22589737_ChIP-Seq_MCF10A_Human0.87990345
79ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86453525
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86450413
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84204793
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.83582270
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81677702
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81567442
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79554573
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79161647
87IGF1R_20145208_ChIP-Seq_DFB_Human0.78745855
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.76396456
89SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76069248
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.75219762
91HTT_18923047_ChIP-ChIP_STHdh_Human0.72648648
92CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70354364
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.69709579
94NOTCH1_21737748_ChIP-Seq_TLL_Human0.69556171
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67342084
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.66317582
97P300_19829295_ChIP-Seq_ESCs_Human0.65622925
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.64790765
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64568034
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.64043852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.84750440
2MP0010094_abnormal_chromosome_stability3.80809408
3MP0003718_maternal_effect3.73269953
4MP0003693_abnormal_embryo_hatching3.50936554
5MP0008058_abnormal_DNA_repair3.38789061
6MP0008789_abnormal_olfactory_epithelium3.18317505
7MP0008877_abnormal_DNA_methylation2.97485039
8MP0009379_abnormal_foot_pigmentation2.81504757
9MP0003111_abnormal_nucleus_morphology2.74508622
10MP0010030_abnormal_orbit_morphology2.69410079
11MP0004957_abnormal_blastocyst_morpholog2.64436346
12MP0003077_abnormal_cell_cycle2.56683504
13MP0005499_abnormal_olfactory_system2.53164013
14MP0005394_taste/olfaction_phenotype2.53164013
15MP0008932_abnormal_embryonic_tissue2.28542295
16MP0001293_anophthalmia2.12580304
17MP0002234_abnormal_pharynx_morphology2.09538000
18MP0008057_abnormal_DNA_replication1.98581962
19MP0003136_yellow_coat_color1.91228796
20MP0003121_genomic_imprinting1.90201774
21MP0001984_abnormal_olfaction1.78251095
22MP0000372_irregular_coat_pigmentation1.78053312
23MP0003890_abnormal_embryonic-extraembry1.77661802
24MP0006072_abnormal_retinal_apoptosis1.67058057
25MP0001529_abnormal_vocalization1.66667578
26MP0002102_abnormal_ear_morphology1.66588613
27MP0003786_premature_aging1.63523188
28MP0002210_abnormal_sex_determination1.63456526
29MP0002160_abnormal_reproductive_system1.62746054
30MP0008007_abnormal_cellular_replicative1.54891132
31MP0002938_white_spotting1.53254667
32MP0004142_abnormal_muscle_tone1.50008118
33MP0001929_abnormal_gametogenesis1.48740064
34MP0008995_early_reproductive_senescence1.46369622
35MP0003186_abnormal_redox_activity1.45813288
36MP0000049_abnormal_middle_ear1.31779292
37MP0006036_abnormal_mitochondrial_physio1.29715560
38MP0000653_abnormal_sex_gland1.28214541
39MP0000631_abnormal_neuroendocrine_gland1.27987652
40MP0002233_abnormal_nose_morphology1.27730790
41MP0005551_abnormal_eye_electrophysiolog1.26009565
42MP0000566_synostosis1.25877878
43MP0001145_abnormal_male_reproductive1.22821440
44MP0003806_abnormal_nucleotide_metabolis1.20962333
45MP0006035_abnormal_mitochondrial_morpho1.16475649
46MP0005389_reproductive_system_phenotype1.15786177
47MP0005410_abnormal_fertilization1.15518765
48MP0002638_abnormal_pupillary_reflex1.14536184
49MP0005395_other_phenotype1.12091832
50MP0003698_abnormal_male_reproductive1.11087611
51MP0002095_abnormal_skin_pigmentation1.07939808
52MP0001485_abnormal_pinna_reflex1.07550893
53MP0005174_abnormal_tail_pigmentation1.03930475
54MP0003880_abnormal_central_pattern1.02236989
55MP0001286_abnormal_eye_development1.00803617
56MP0006276_abnormal_autonomic_nervous0.99462298
57MP0005171_absent_coat_pigmentation0.98850641
58MP0003122_maternal_imprinting0.98018326
59MP0005075_abnormal_melanosome_morpholog0.97446599
60MP0003938_abnormal_ear_development0.96409564
61MP0009697_abnormal_copulation0.95965420
62MP0005084_abnormal_gallbladder_morpholo0.95613517
63MP0002163_abnormal_gland_morphology0.94975959
64MP0002736_abnormal_nociception_after0.94585360
65MP0003787_abnormal_imprinting0.93994044
66MP0003937_abnormal_limbs/digits/tail_de0.93887514
67MP0001119_abnormal_female_reproductive0.93073091
68MP0002161_abnormal_fertility/fecundity0.92455951
69MP0002653_abnormal_ependyma_morphology0.92133868
70MP0001324_abnormal_eye_pigmentation0.90795624
71MP0001905_abnormal_dopamine_level0.89952996
72MP0002272_abnormal_nervous_system0.89428133
73MP0003699_abnormal_female_reproductive0.84277399
74MP0003119_abnormal_digestive_system0.83663127
75MP0001730_embryonic_growth_arrest0.83471610
76MP0005253_abnormal_eye_physiology0.81615160
77MP0002697_abnormal_eye_size0.80324734
78MP0003183_abnormal_peptide_metabolism0.79411750
79MP0000778_abnormal_nervous_system0.77768233
80MP0005195_abnormal_posterior_eye0.77041986
81MP0000350_abnormal_cell_proliferation0.76890686
82MP0001188_hyperpigmentation0.76390159
83MP0001697_abnormal_embryo_size0.75302893
84MP0005391_vision/eye_phenotype0.74855698
85MP0002085_abnormal_embryonic_tissue0.74832472
86MP0009046_muscle_twitch0.73790689
87MP0004147_increased_porphyrin_level0.72396575
88MP0002752_abnormal_somatic_nervous0.71710227
89MP0003567_abnormal_fetal_cardiomyocyte0.71579777
90MP0004133_heterotaxia0.71471513
91MP0002751_abnormal_autonomic_nervous0.70755810
92MP0003123_paternal_imprinting0.70662651
93MP0000026_abnormal_inner_ear0.69802782
94MP0000358_abnormal_cell_content/0.69368509
95MP0005377_hearing/vestibular/ear_phenot0.67018917
96MP0003878_abnormal_ear_physiology0.67018917
97MP0001919_abnormal_reproductive_system0.65904484
98MP0002735_abnormal_chemical_nociception0.65776991
99MP0005646_abnormal_pituitary_gland0.64078692
100MP0003861_abnormal_nervous_system0.63441503

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.88204279
2Abnormal mitochondria in muscle tissue (HP:0008316)4.56699159
3Acute encephalopathy (HP:0006846)4.32343517
4Mitochondrial inheritance (HP:0001427)4.08918270
5Abnormality of the labia minora (HP:0012880)3.97288551
6Progressive macrocephaly (HP:0004481)3.91051702
7Reticulocytopenia (HP:0001896)3.82752190
8Increased CSF lactate (HP:0002490)3.72512923
9Increased hepatocellular lipid droplets (HP:0006565)3.71334574
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.70942051
11Chromsome breakage (HP:0040012)3.56568158
12Renal Fanconi syndrome (HP:0001994)3.47176557
13Lipid accumulation in hepatocytes (HP:0006561)3.45075790
14Hepatocellular necrosis (HP:0001404)3.37381574
15Septo-optic dysplasia (HP:0100842)3.21030072
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.19336257
17Cerebral edema (HP:0002181)3.17459005
18Supernumerary spleens (HP:0009799)3.17322220
19Hepatic necrosis (HP:0002605)3.16129659
20Meckel diverticulum (HP:0002245)3.09080794
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.07309655
22Molar tooth sign on MRI (HP:0002419)2.92770921
23Abnormality of midbrain morphology (HP:0002418)2.92770921
24Abnormality of the ileum (HP:0001549)2.90065812
25Myokymia (HP:0002411)2.86154176
26Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.82225290
27Decreased activity of mitochondrial respiratory chain (HP:0008972)2.82225290
28Oligodactyly (hands) (HP:0001180)2.81734070
29Macrocytic anemia (HP:0001972)2.74999888
30Increased intramyocellular lipid droplets (HP:0012240)2.72883162
31Abnormality of the preputium (HP:0100587)2.70278327
32Abnormality of cells of the erythroid lineage (HP:0012130)2.68558797
333-Methylglutaconic aciduria (HP:0003535)2.67983415
34Abnormality of chromosome stability (HP:0003220)2.61392609
35Colon cancer (HP:0003003)2.60130117
36Absent septum pellucidum (HP:0001331)2.58347871
37Abnormal number of erythroid precursors (HP:0012131)2.52563670
38Exertional dyspnea (HP:0002875)2.49993093
39Duodenal stenosis (HP:0100867)2.45513407
40Small intestinal stenosis (HP:0012848)2.45513407
41Increased serum lactate (HP:0002151)2.45235797
42Aplastic anemia (HP:0001915)2.43969823
43Abnormal lung lobation (HP:0002101)2.41366849
44Pancreatic fibrosis (HP:0100732)2.38896033
45Absent thumb (HP:0009777)2.37546268
46Lactic acidosis (HP:0003128)2.36649876
47Oligodactyly (HP:0012165)2.36103802
48Leukodystrophy (HP:0002415)2.30912446
49Impulsivity (HP:0100710)2.28078726
50Respiratory failure (HP:0002878)2.28021615
51Hyperglycinemia (HP:0002154)2.27463180
52Volvulus (HP:0002580)2.26905356
53Birth length less than 3rd percentile (HP:0003561)2.22980126
54Exercise intolerance (HP:0003546)2.22728524
55Triphalangeal thumb (HP:0001199)2.22078732
56Optic disc pallor (HP:0000543)2.21204153
57Increased muscle lipid content (HP:0009058)2.20587170
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.17813171
59Median cleft lip (HP:0000161)2.17779308
60Pancreatic cysts (HP:0001737)2.14479217
61Abnormality of the septum pellucidum (HP:0007375)2.13252834
62Stenosis of the external auditory canal (HP:0000402)2.12131921
63Abnormality of renal resorption (HP:0011038)2.11362769
64Medial flaring of the eyebrow (HP:0010747)2.09286891
65Respiratory difficulties (HP:0002880)2.07981898
66Abnormality of the duodenum (HP:0002246)2.07555953
67Pallor (HP:0000980)2.04546107
68Pancytopenia (HP:0001876)2.03652928
69Degeneration of anterior horn cells (HP:0002398)2.03582619
70Abnormality of the anterior horn cell (HP:0006802)2.03582619
71Abnormal respiratory motile cilium physiology (HP:0012261)2.02161180
72Bifid tongue (HP:0010297)2.02024588
73Cleft eyelid (HP:0000625)2.01784872
74Ectopic kidney (HP:0000086)2.00214425
75Abdominal situs inversus (HP:0003363)1.99706177
76Abnormality of abdominal situs (HP:0011620)1.99706177
77Rhinitis (HP:0012384)1.97212134
78Aplasia/Hypoplasia of the tongue (HP:0010295)1.95879129
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92943549
80True hermaphroditism (HP:0010459)1.91700566
81Generalized aminoaciduria (HP:0002909)1.91122438
82X-linked dominant inheritance (HP:0001423)1.90652910
83Multiple enchondromatosis (HP:0005701)1.90191932
84Horseshoe kidney (HP:0000085)1.89092435
85Sloping forehead (HP:0000340)1.88599355
86Short tibia (HP:0005736)1.86502155
87Microvesicular hepatic steatosis (HP:0001414)1.85961126
88Methylmalonic acidemia (HP:0002912)1.85045316
89Maternal diabetes (HP:0009800)1.84573817
90Sclerocornea (HP:0000647)1.83476558
91Glycosuria (HP:0003076)1.81157313
92Abnormality of urine glucose concentration (HP:0011016)1.81157313
93Abnormal ciliary motility (HP:0012262)1.80362935
94Oral leukoplakia (HP:0002745)1.79362626
95Abnormality of the carotid arteries (HP:0005344)1.79069809
96Methylmalonic aciduria (HP:0012120)1.78421646
97Lethargy (HP:0001254)1.75865129
98Preaxial hand polydactyly (HP:0001177)1.73574019
99Pendular nystagmus (HP:0012043)1.73196011
100Myelodysplasia (HP:0002863)1.71913525

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.51728148
2BUB14.03211069
3VRK23.72179635
4STK162.82820435
5PLK42.65557838
6ZAK2.62727815
7TRIM282.55120986
8TTK2.40479394
9SRPK12.20619401
10NEK12.15046624
11VRK12.13034482
12WEE12.11028229
13PLK32.08346587
14PBK1.94680955
15BCKDK1.93716766
16PLK11.90487014
17NUAK11.89788743
18TNIK1.85441939
19WNK31.78403724
20BRSK21.73619224
21DYRK21.58945803
22TESK21.54287838
23MST41.52189981
24NME11.50024316
25BRSK11.46924075
26ARAF1.45050486
27AURKA1.42514233
28NEK21.35238313
29AURKB1.31028544
30BMPR1B1.28062710
31MAP4K21.27343702
32CHEK21.24986643
33ATR1.20738642
34NME21.18675910
35CDK191.18579440
36EIF2AK31.10044459
37MAP3K91.08914157
38TAF11.06715721
39CSNK1G31.02883346
40PLK20.98123922
41BRAF0.97777348
42MKNK10.97713347
43CSNK1G10.94818532
44CDK70.92860390
45KDR0.91600549
46CSNK1G20.90216703
47MKNK20.90042666
48PDK20.87270066
49MAP2K70.86626935
50CDK80.81049647
51CCNB10.79714924
52CSNK1A1L0.79048857
53MAP3K40.78142352
54BCR0.77842512
55EIF2AK10.75938731
56CHEK10.75398820
57PRKCI0.73997432
58MINK10.72791732
59PNCK0.72239238
60TLK10.71977902
61ATM0.71561202
62TSSK60.70724162
63CSNK2A20.69244070
64CSNK2A10.68218286
65DYRK30.66616631
66OXSR10.66425965
67PRKCG0.66264032
68EIF2AK20.61421961
69MAPK130.60494577
70STK30.60074160
71CASK0.59120698
72MARK30.57754685
73LRRK20.57040497
74CDK20.56390236
75INSRR0.53927927
76STK240.53093292
77PAK10.53075876
78CDK90.51904042
79ADRBK20.51837743
80CDK10.51824675
81TESK10.51324976
82STK390.50330254
83GRK10.50140802
84CSNK1E0.49625467
85CDK140.48424785
86PKN10.47515765
87STK40.46703232
88LIMK10.46594917
89MAP3K120.44995075
90CDK11A0.43968783
91WNK40.43718301
92ABL20.43548527
93CDK180.42602096
94ACVR1B0.42480661
95CDK150.41188342
96MAP3K80.40878925
97RPS6KA50.39573156
98TIE10.39354254
99TAOK30.38795906
100DAPK10.36962023

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.95859269
2Mismatch repair_Homo sapiens_hsa034303.86502169
3Proteasome_Homo sapiens_hsa030503.84538297
4Oxidative phosphorylation_Homo sapiens_hsa001903.77635884
5Ribosome_Homo sapiens_hsa030103.61384604
6Parkinsons disease_Homo sapiens_hsa050123.35819311
7Homologous recombination_Homo sapiens_hsa034403.11680287
8RNA polymerase_Homo sapiens_hsa030203.02792084
9Base excision repair_Homo sapiens_hsa034102.73573853
10Fanconi anemia pathway_Homo sapiens_hsa034602.71538066
11Huntingtons disease_Homo sapiens_hsa050162.55196651
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.29320324
13Nucleotide excision repair_Homo sapiens_hsa034202.26201580
14Protein export_Homo sapiens_hsa030602.24326021
15Alzheimers disease_Homo sapiens_hsa050102.12922648
16Spliceosome_Homo sapiens_hsa030402.08924561
17Cell cycle_Homo sapiens_hsa041101.90304227
18Basal transcription factors_Homo sapiens_hsa030221.87373247
19RNA degradation_Homo sapiens_hsa030181.86054547
20Non-homologous end-joining_Homo sapiens_hsa034501.85668478
21Pyrimidine metabolism_Homo sapiens_hsa002401.81688637
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.70969289
23RNA transport_Homo sapiens_hsa030131.67703104
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.67001044
25One carbon pool by folate_Homo sapiens_hsa006701.66049792
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62136782
27Cardiac muscle contraction_Homo sapiens_hsa042601.60788587
28Folate biosynthesis_Homo sapiens_hsa007901.49481146
29Purine metabolism_Homo sapiens_hsa002301.30703046
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29139681
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25113635
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.21775982
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20031089
34Oocyte meiosis_Homo sapiens_hsa041141.16541744
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11493960
36Fatty acid elongation_Homo sapiens_hsa000621.03429954
37Propanoate metabolism_Homo sapiens_hsa006401.03028003
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01757639
39Phototransduction_Homo sapiens_hsa047440.99941871
40Pyruvate metabolism_Homo sapiens_hsa006200.97649233
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93312269
42Glutathione metabolism_Homo sapiens_hsa004800.90178147
43Sulfur relay system_Homo sapiens_hsa041220.84322983
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72870497
45mRNA surveillance pathway_Homo sapiens_hsa030150.71499530
46Metabolic pathways_Homo sapiens_hsa011000.71496783
47Caffeine metabolism_Homo sapiens_hsa002320.66367263
48Nicotine addiction_Homo sapiens_hsa050330.66197706
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65973980
50Steroid biosynthesis_Homo sapiens_hsa001000.65642236
51Butanoate metabolism_Homo sapiens_hsa006500.64815766
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63919034
53Peroxisome_Homo sapiens_hsa041460.62401372
54p53 signaling pathway_Homo sapiens_hsa041150.62322468
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60369336
56Selenocompound metabolism_Homo sapiens_hsa004500.58682582
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56731646
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52699002
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.51452947
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50636441
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49833129
62Olfactory transduction_Homo sapiens_hsa047400.48674574
63Collecting duct acid secretion_Homo sapiens_hsa049660.47979158
64Carbon metabolism_Homo sapiens_hsa012000.41936932
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41688539
66Biosynthesis of amino acids_Homo sapiens_hsa012300.40172338
67Tryptophan metabolism_Homo sapiens_hsa003800.39841925
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38973396
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38746908
70Chemical carcinogenesis_Homo sapiens_hsa052040.37223856
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31977321
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31389980
73Fatty acid degradation_Homo sapiens_hsa000710.30142888
74Basal cell carcinoma_Homo sapiens_hsa052170.28621849
75Arginine and proline metabolism_Homo sapiens_hsa003300.27223804
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26852258
77Epstein-Barr virus infection_Homo sapiens_hsa051690.26220719
78Vitamin digestion and absorption_Homo sapiens_hsa049770.24888481
79Hedgehog signaling pathway_Homo sapiens_hsa043400.24698765
80Systemic lupus erythematosus_Homo sapiens_hsa053220.24572464
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23205275
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22114208
83Tyrosine metabolism_Homo sapiens_hsa003500.21840821
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20880609
85Alcoholism_Homo sapiens_hsa050340.20815309
86Fatty acid metabolism_Homo sapiens_hsa012120.19815076
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.19308955
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.18893837
89beta-Alanine metabolism_Homo sapiens_hsa004100.17429930
90Nitrogen metabolism_Homo sapiens_hsa009100.16584581
91Retinol metabolism_Homo sapiens_hsa008300.15810159
92Synaptic vesicle cycle_Homo sapiens_hsa047210.15390155
93Taste transduction_Homo sapiens_hsa047420.14079123
94Linoleic acid metabolism_Homo sapiens_hsa005910.13337205
95GABAergic synapse_Homo sapiens_hsa047270.12529817
96Phenylalanine metabolism_Homo sapiens_hsa003600.12100171
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.11875175
98Hippo signaling pathway_Homo sapiens_hsa043900.11713542
99Regulation of autophagy_Homo sapiens_hsa041400.10426806
100Sulfur metabolism_Homo sapiens_hsa009200.10390617

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