APIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.35359646
2ATP synthesis coupled proton transport (GO:0015986)6.07749391
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.07749391
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.87170662
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.84474602
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.84474602
7NADH dehydrogenase complex assembly (GO:0010257)4.84474602
8proteasome assembly (GO:0043248)4.82803555
9respiratory electron transport chain (GO:0022904)4.77218782
10ribosomal small subunit assembly (GO:0000028)4.72657404
11electron transport chain (GO:0022900)4.66375250
12chaperone-mediated protein transport (GO:0072321)4.34412904
13protein complex biogenesis (GO:0070271)4.33921117
14protein neddylation (GO:0045116)4.31792561
15DNA deamination (GO:0045006)4.30950918
16oxidative phosphorylation (GO:0006119)4.30373300
17protein deneddylation (GO:0000338)4.07733766
18cullin deneddylation (GO:0010388)4.05795185
19mitochondrial respiratory chain complex assembly (GO:0033108)3.97512353
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.97437201
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.92556751
22water-soluble vitamin biosynthetic process (GO:0042364)3.90480736
23ribosomal small subunit biogenesis (GO:0042274)3.86639472
24regulation of cellular amino acid metabolic process (GO:0006521)3.81829194
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.77618104
26antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.77242795
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75556977
28telomere maintenance via semi-conservative replication (GO:0032201)3.71088117
29respiratory chain complex IV assembly (GO:0008535)3.71021954
30intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.68882951
31signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.68882951
32regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66986748
33negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65016875
34negative regulation of ligase activity (GO:0051352)3.65016875
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64042015
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64042015
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64042015
38rRNA modification (GO:0000154)3.61066899
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.60441129
40maturation of SSU-rRNA (GO:0030490)3.60252859
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58465236
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.57907327
43tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.57907327
44cotranslational protein targeting to membrane (GO:0006613)3.56851565
45pseudouridine synthesis (GO:0001522)3.55111985
46viral transcription (GO:0019083)3.50521141
47protein targeting to ER (GO:0045047)3.49923466
48CENP-A containing nucleosome assembly (GO:0034080)3.49539773
49signal transduction involved in DNA integrity checkpoint (GO:0072401)3.48641799
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.48641799
51translational termination (GO:0006415)3.46973388
52DNA strand elongation involved in DNA replication (GO:0006271)3.46853368
53telomere maintenance via recombination (GO:0000722)3.45734052
54pteridine-containing compound biosynthetic process (GO:0042559)3.44483992
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.42475284
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38386849
57* L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.38263131
58heart process (GO:0003015)3.37591687
59heart contraction (GO:0060047)3.37591687
60signal peptide processing (GO:0006465)3.36781352
61cytochrome complex assembly (GO:0017004)3.36476603
62DNA double-strand break processing (GO:0000729)3.36212535
63nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.36077462
64protein localization to endoplasmic reticulum (GO:0070972)3.35854147
65aerobic respiration (GO:0009060)3.35458113
66translation (GO:0006412)3.30434448
67establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30087822
68rRNA methylation (GO:0031167)3.28917009
697-methylguanosine mRNA capping (GO:0006370)3.26406805
70DNA strand elongation (GO:0022616)3.26172816
71chromatin remodeling at centromere (GO:0031055)3.25724843
72RNA capping (GO:0036260)3.24226000
737-methylguanosine RNA capping (GO:0009452)3.24226000
74termination of RNA polymerase III transcription (GO:0006386)3.22207670
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.22207670
76establishment of protein localization to mitochondrial membrane (GO:0090151)3.19769791
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18241787
78formation of translation preinitiation complex (GO:0001731)3.15289639
79positive regulation of ligase activity (GO:0051351)3.13698014
80mitotic recombination (GO:0006312)3.12436313
812-deoxyribonucleotide biosynthetic process (GO:0009265)3.09110964
82deoxyribose phosphate biosynthetic process (GO:0046385)3.09110964
83folic acid-containing compound biosynthetic process (GO:0009396)3.08653024
84deoxyribonucleotide biosynthetic process (GO:0009263)3.08400497
85purine nucleobase biosynthetic process (GO:0009113)3.08258653
86ubiquinone biosynthetic process (GO:0006744)3.07595855
87antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.07494721
88regulation of mitochondrial translation (GO:0070129)3.07457013
89translational elongation (GO:0006414)3.07349663
90deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07142696
91protein targeting to mitochondrion (GO:0006626)3.06961480
92platelet dense granule organization (GO:0060155)3.05868866
93GTP biosynthetic process (GO:0006183)3.05386212
94purine nucleoside triphosphate biosynthetic process (GO:0009145)3.03358479
95histone exchange (GO:0043486)3.03192600
96purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.01854009
97DNA catabolic process, exonucleolytic (GO:0000738)3.00847643
98ATP biosynthetic process (GO:0006754)3.00844808
99transcription-coupled nucleotide-excision repair (GO:0006283)3.00223248
100deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99443184
101synapsis (GO:0007129)2.99401436
102DNA replication checkpoint (GO:0000076)2.97353321
103peptidyl-histidine modification (GO:0018202)2.93251530
104protein-cofactor linkage (GO:0018065)2.92479503
105inner mitochondrial membrane organization (GO:0007007)2.90859047
106replication fork processing (GO:0031297)2.90206397
107establishment of protein localization to mitochondrion (GO:0072655)2.89391373
108cellular component biogenesis (GO:0044085)2.86491161
109cell cycle G1/S phase transition (GO:0044843)2.85784793
110G1/S transition of mitotic cell cycle (GO:0000082)2.85784793
111DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.85175244
112kinetochore organization (GO:0051383)2.85152961
113DNA replication initiation (GO:0006270)2.84282913
114ubiquinone metabolic process (GO:0006743)2.82886097
115translational initiation (GO:0006413)2.82406106
116adenosine metabolic process (GO:0046085)2.80919671
117positive regulation of cell cycle arrest (GO:0071158)2.80241844
118ribosomal large subunit biogenesis (GO:0042273)2.79965385
119protein localization to mitochondrion (GO:0070585)2.79427754
120kinetochore assembly (GO:0051382)2.78744674
121regulation of ubiquitin-protein transferase activity (GO:0051438)2.78669584
122tRNA processing (GO:0008033)2.77016080
123cellular ketone body metabolic process (GO:0046950)2.75978161
124protein K6-linked ubiquitination (GO:0085020)2.75543999
125nucleobase biosynthetic process (GO:0046112)2.74582468
126lactate metabolic process (GO:0006089)2.73968301
127resolution of meiotic recombination intermediates (GO:0000712)2.71620444
128ketone body metabolic process (GO:1902224)2.69700063
129hydrogen ion transmembrane transport (GO:1902600)2.68663237
130regulation of hexokinase activity (GO:1903299)2.67705128
131regulation of glucokinase activity (GO:0033131)2.67705128
132organelle disassembly (GO:1903008)2.66968330
133C-terminal protein lipidation (GO:0006501)2.66397397
134response to pheromone (GO:0019236)2.66308756
135somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66020557
136somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66020557
137isotype switching (GO:0045190)2.66020557
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.64630313
139ribosome assembly (GO:0042255)2.64616608
140regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.64450327
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.64146197
142preassembly of GPI anchor in ER membrane (GO:0016254)2.62879669
143AMP metabolic process (GO:0046033)2.62469600
144regulation of cilium movement (GO:0003352)2.59866380
145tRNA metabolic process (GO:0006399)2.58304237
146mitochondrial RNA metabolic process (GO:0000959)2.55057164
147C-terminal protein amino acid modification (GO:0018410)2.54808623
148DNA damage response, detection of DNA damage (GO:0042769)2.54430851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.08718737
2E2F7_22180533_ChIP-Seq_HELA_Human4.88924870
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.37437470
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.20530535
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.95707495
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71534360
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.59100514
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.50657417
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47544797
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.42320385
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.32852739
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.17940012
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.02009517
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.89883258
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85224935
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.84105604
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76841596
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.75569809
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70152119
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62841770
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.52773378
22VDR_23849224_ChIP-Seq_CD4+_Human2.52767607
23ZNF274_21170338_ChIP-Seq_K562_Hela2.48901685
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45388881
25* DCP1A_22483619_ChIP-Seq_HELA_Human2.42503894
26ELK1_19687146_ChIP-ChIP_HELA_Human2.38968697
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32494256
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32336128
29* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.28449791
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22341381
31VDR_22108803_ChIP-Seq_LS180_Human2.12346010
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09853682
33IGF1R_20145208_ChIP-Seq_DFB_Human2.09712483
34* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08949764
35HOXB4_20404135_ChIP-ChIP_EML_Mouse2.07760570
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06212433
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99422146
38FOXP3_21729870_ChIP-Seq_TREG_Human1.94853349
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.93779135
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92794799
41XRN2_22483619_ChIP-Seq_HELA_Human1.90909955
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88248544
43EWS_26573619_Chip-Seq_HEK293_Human1.85873484
44* FUS_26573619_Chip-Seq_HEK293_Human1.83385567
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80878138
46GABP_19822575_ChIP-Seq_HepG2_Human1.79189820
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.76655678
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.74861286
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72390509
50TTF2_22483619_ChIP-Seq_HELA_Human1.70120116
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69619917
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.69164080
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65888150
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57595584
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57529305
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.53414353
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52502424
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49407841
59* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49133309
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47163001
61* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47159025
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46894212
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46185539
64P300_19829295_ChIP-Seq_ESCs_Human1.39740989
65* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37215221
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.35884657
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34418084
68CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.34235869
69* ELK1_22589737_ChIP-Seq_MCF10A_Human1.32550519
70TP53_22573176_ChIP-Seq_HFKS_Human1.30828525
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28477592
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27790825
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27349228
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27008041
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26546064
76AR_21909140_ChIP-Seq_LNCAP_Human1.26168297
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25307759
78TAF15_26573619_Chip-Seq_HEK293_Human1.24430779
79* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22570751
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22358867
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22063205
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21797724
83* E2F1_21310950_ChIP-Seq_MCF-7_Human1.20421283
84NANOG_19829295_ChIP-Seq_ESCs_Human1.19927862
85SOX2_19829295_ChIP-Seq_ESCs_Human1.19927862
86ER_23166858_ChIP-Seq_MCF-7_Human1.18189733
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17577966
88GBX2_23144817_ChIP-Seq_PC3_Human1.16076445
89ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15885953
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15248563
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14548767
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13842687
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13761480
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13584584
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.11382880
96MYC_18940864_ChIP-ChIP_HL60_Human1.10767214
97IRF1_19129219_ChIP-ChIP_H3396_Human1.08440952
98EZH2_27294783_Chip-Seq_NPCs_Mouse1.07834734
99SPI1_23547873_ChIP-Seq_NB4_Human1.07586350
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07350661
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06921067
102CBP_20019798_ChIP-Seq_JUKART_Human1.06921067
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05259809
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02710033
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01271874
106FOXA1_25329375_ChIP-Seq_VCAP_Human1.01271874
107AR_20517297_ChIP-Seq_VCAP_Human1.00733532
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98006837
109HTT_18923047_ChIP-ChIP_STHdh_Human0.94960507
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94778835
111NFE2_27457419_Chip-Seq_LIVER_Mouse0.93771416
112KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93739172
113FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93690461
114GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93308685
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92211469
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92017109
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91962908
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90960146
119NCOR_22424771_ChIP-Seq_293T_Human0.90189095
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89245070
121PHF8_20622853_ChIP-Seq_HELA_Human0.89051060
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.89001879
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.87765682
124* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87412697
125STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85955197
126SALL4_22934838_ChIP-ChIP_CD34+_Human0.83685725
127AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83290936
128TFEB_21752829_ChIP-Seq_HELA_Human0.80417781
129GATA4_21415370_ChIP-Seq_HL-1_Mouse0.77954815
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77081962
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75550303
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75544626
133TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74740487
134KDM5A_27292631_Chip-Seq_BREAST_Human0.74554155
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74260562
136KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.72413493
137GATA1_22025678_ChIP-Seq_K562_Human0.71116880
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.69180370
139FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69147901
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69119555
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.68936637
142NOTCH1_21737748_ChIP-Seq_TLL_Human0.68318418
143STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.67433035
144LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.65829421

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003186_abnormal_redox_activity3.65197321
2MP0003806_abnormal_nucleotide_metabolis3.04422418
3MP0003646_muscle_fatigue2.91288062
4MP0006036_abnormal_mitochondrial_physio2.89334380
5MP0003693_abnormal_embryo_hatching2.77128732
6MP0009379_abnormal_foot_pigmentation2.75364008
7MP0008057_abnormal_DNA_replication2.65029740
8MP0006072_abnormal_retinal_apoptosis2.62169988
9MP0010094_abnormal_chromosome_stability2.60330702
10MP0003656_abnormal_erythrocyte_physiolo2.54169163
11MP0003195_calcinosis2.52666523
12MP0001835_abnormal_antigen_presentation2.37382764
13MP0004957_abnormal_blastocyst_morpholog2.25571134
14MP0003077_abnormal_cell_cycle2.16810253
15MP0002148_abnormal_hypersensitivity_rea2.15449836
16MP0002139_abnormal_hepatobiliary_system2.12475702
17MP0004147_increased_porphyrin_level2.09650579
18MP0008058_abnormal_DNA_repair2.08112256
19MP0000749_muscle_degeneration2.07707783
20MP0009697_abnormal_copulation1.96825372
21MP0009785_altered_susceptibility_to1.94181138
22MP0008007_abnormal_cellular_replicative1.92927814
23MP0001853_heart_inflammation1.91588012
24MP0002132_abnormal_respiratory_system1.85003752
25MP0000372_irregular_coat_pigmentation1.84585932
26MP0003724_increased_susceptibility_to1.84467438
27MP0005075_abnormal_melanosome_morpholog1.82118688
28MP0002163_abnormal_gland_morphology1.79318548
29MP0005253_abnormal_eye_physiology1.73708808
30MP0005408_hypopigmentation1.72092871
31MP0001984_abnormal_olfaction1.72003336
32MP0003111_abnormal_nucleus_morphology1.68301156
33MP0005084_abnormal_gallbladder_morpholo1.67681149
34MP0005646_abnormal_pituitary_gland1.65240924
35MP0003718_maternal_effect1.64063901
36MP0008932_abnormal_embryonic_tissue1.61748382
37MP0004084_abnormal_cardiac_muscle1.58749031
38MP0000343_altered_response_to1.58182806
39MP0006054_spinal_hemorrhage1.47572852
40MP0005551_abnormal_eye_electrophysiolog1.46441959
41MP0008995_early_reproductive_senescence1.45105345
42MP0005671_abnormal_response_to1.44592476
43MP0002938_white_spotting1.43912623
44MP0005332_abnormal_amino_acid1.43412902
45MP0001764_abnormal_homeostasis1.41289875
46MP0006035_abnormal_mitochondrial_morpho1.41285877
47MP0005410_abnormal_fertilization1.39890742
48MP0001905_abnormal_dopamine_level1.39719885
49MP0005645_abnormal_hypothalamus_physiol1.37946586
50MP0005451_abnormal_body_composition1.37233871
51MP0004145_abnormal_muscle_electrophysio1.36743869
52MP0008775_abnormal_heart_ventricle1.35646210
53MP0008875_abnormal_xenobiotic_pharmacok1.34197451
54MP0004215_abnormal_myocardial_fiber1.33135835
55MP0002419_abnormal_innate_immunity1.30065446
56MP0002396_abnormal_hematopoietic_system1.28301228
57MP0001986_abnormal_taste_sensitivity1.27088716
58MP0002638_abnormal_pupillary_reflex1.26278572
59MP0009333_abnormal_splenocyte_physiolog1.23436421
60MP0005266_abnormal_metabolism1.23169214
61MP0005000_abnormal_immune_tolerance1.22862106
62MP0009046_muscle_twitch1.20145599
63MP0003786_premature_aging1.16903969
64MP0003567_abnormal_fetal_cardiomyocyte1.16871506
65MP0005025_abnormal_response_to1.16581317
66MP0001929_abnormal_gametogenesis1.16067823
67MP0005330_cardiomyopathy1.15672319
68MP0002090_abnormal_vision1.15599301
69MP0008872_abnormal_physiological_respon1.14741621
70MP0004036_abnormal_muscle_relaxation1.14365983
71MP0002837_dystrophic_cardiac_calcinosis1.12609556
72MP0002095_abnormal_skin_pigmentation1.11249391
73MP0002972_abnormal_cardiac_muscle1.10975980
74MP0002160_abnormal_reproductive_system1.10603769
75MP0001544_abnormal_cardiovascular_syste1.10472922
76MP0005385_cardiovascular_system_phenoty1.10472922
77MP0005636_abnormal_mineral_homeostasis1.09964269
78MP0003221_abnormal_cardiomyocyte_apopto1.09675056
79MP0001529_abnormal_vocalization1.08688423
80MP0002254_reproductive_system_inflammat1.08531985
81MP0003950_abnormal_plasma_membrane1.08441180
82MP0003011_delayed_dark_adaptation1.06536123
83MP0010386_abnormal_urinary_bladder1.05786479
84MP0002736_abnormal_nociception_after1.04394411
85MP0008789_abnormal_olfactory_epithelium1.02798558
86MP0002277_abnormal_respiratory_mucosa1.02009462
87MP0002452_abnormal_antigen_presenting1.01450841
88MP0000631_abnormal_neuroendocrine_gland1.00207265
89MP0002210_abnormal_sex_determination0.99737212
90MP0003436_decreased_susceptibility_to0.98971326
91MP0000685_abnormal_immune_system0.95029684
92MP0000750_abnormal_muscle_regeneration0.94803771
93MP0005376_homeostasis/metabolism_phenot0.94700553
94MP0005379_endocrine/exocrine_gland_phen0.94622049
95MP0005187_abnormal_penis_morphology0.94306700
96MP0002693_abnormal_pancreas_physiology0.94250275
97MP0001968_abnormal_touch/_nociception0.92367809
98MP0000653_abnormal_sex_gland0.92250227
99MP0001661_extended_life_span0.92115787
100MP0005389_reproductive_system_phenotype0.91533051
101MP0002723_abnormal_immune_serum0.91135177
102MP0008469_abnormal_protein_level0.89976938
103MP0000015_abnormal_ear_pigmentation0.89895547
104MP0002234_abnormal_pharynx_morphology0.89163741
105MP0009764_decreased_sensitivity_to0.88488216
106MP0002405_respiratory_system_inflammati0.88176345
107MP0003137_abnormal_impulse_conducting0.87532868
108MP0001800_abnormal_humoral_immune0.87104733
109MP0001324_abnormal_eye_pigmentation0.85822346
110MP0002102_abnormal_ear_morphology0.85454987
111MP0002420_abnormal_adaptive_immunity0.85100920
112MP0002106_abnormal_muscle_physiology0.84860827
113MP0001819_abnormal_immune_cell0.84475287
114MP0002138_abnormal_hepatobiliary_system0.84186071
115MP0005387_immune_system_phenotype0.83714958
116MP0001790_abnormal_immune_system0.83714958
117MP0006276_abnormal_autonomic_nervous0.83131762
118MP0001485_abnormal_pinna_reflex0.82953092
119MP0003698_abnormal_male_reproductive0.82347232
120MP0008260_abnormal_autophagy0.82022660
121MP0004043_abnormal_pH_regulation0.81347494
122MP0000689_abnormal_spleen_morphology0.81299255
123MP0006292_abnormal_olfactory_placode0.80850142
124MP0005083_abnormal_biliary_tract0.80629527
125MP0001145_abnormal_male_reproductive0.80552549
126MP0006138_congestive_heart_failure0.80381618
127MP0002876_abnormal_thyroid_physiology0.80320856
128MP0004142_abnormal_muscle_tone0.80094939
129MP0008438_abnormal_cutaneous_collagen0.79963027
130MP0005367_renal/urinary_system_phenotyp0.79046783
131MP0000516_abnormal_urinary_system0.79046783
132MP0003136_yellow_coat_color0.78805626
133MP0005165_increased_susceptibility_to0.77557346
134MP0002127_abnormal_cardiovascular_syste0.77169959
135MP0005174_abnormal_tail_pigmentation0.77119056
136MP0000647_abnormal_sebaceous_gland0.75446036
137MP0002429_abnormal_blood_cell0.74809370
138MP0001293_anophthalmia0.74688550
139MP0001944_abnormal_pancreas_morphology0.74400433
140MP0001542_abnormal_bone_strength0.74113404
141MP0000313_abnormal_cell_death0.73428241
142MP0000566_synostosis0.73144012
143MP0000751_myopathy0.73013458
144MP0002398_abnormal_bone_marrow0.72462970
145MP0001879_abnormal_lymphatic_vessel0.72456217
146MP0008877_abnormal_DNA_methylation0.72076540
147MP0000358_abnormal_cell_content/0.71144170
148MP0000716_abnormal_immune_system0.69908581
149MP0005164_abnormal_response_to0.67995282
150MP0002722_abnormal_immune_system0.67638627
151MP0001119_abnormal_female_reproductive0.66806441
152MP0002269_muscular_atrophy0.66392977
153MP0001501_abnormal_sleep_pattern0.65962274
154MP0005395_other_phenotype0.65740024
155MP0005365_abnormal_bile_salt0.64805217
156MP0003252_abnormal_bile_duct0.64758838

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.22609360
2Abnormal mitochondria in muscle tissue (HP:0008316)5.64869990
3Mitochondrial inheritance (HP:0001427)5.51548588
4Acute encephalopathy (HP:0006846)5.23509253
5Hepatocellular necrosis (HP:0001404)5.11212286
6Progressive macrocephaly (HP:0004481)5.00767158
7Increased CSF lactate (HP:0002490)4.97040366
8Hepatic necrosis (HP:0002605)4.96704382
9Increased serum pyruvate (HP:0003542)4.51936468
10Abnormality of glycolysis (HP:0004366)4.51936468
11Increased hepatocellular lipid droplets (HP:0006565)4.08241745
12Lipid accumulation in hepatocytes (HP:0006561)3.88210065
13Cerebral edema (HP:0002181)3.69622968
14Renal Fanconi syndrome (HP:0001994)3.69303170
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.64296784
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.64296784
17Respiratory failure (HP:0002878)3.60762263
18Exercise intolerance (HP:0003546)3.56179056
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.51351899
20Increased serum lactate (HP:0002151)3.50596753
21Birth length less than 3rd percentile (HP:0003561)3.46484359
22Exertional dyspnea (HP:0002875)3.45997205
23Lactic acidosis (HP:0003128)3.37558990
24Abnormality of cells of the erythroid lineage (HP:0012130)3.35132405
25Abnormal number of erythroid precursors (HP:0012131)3.32020724
263-Methylglutaconic aciduria (HP:0003535)3.29374703
27Irregular epiphyses (HP:0010582)3.17745210
28Increased intramyocellular lipid droplets (HP:0012240)3.17160146
29Methylmalonic acidemia (HP:0002912)3.14147965
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.12356005
31Type I transferrin isoform profile (HP:0003642)2.97676384
32Increased muscle lipid content (HP:0009058)2.95252680
33Respiratory difficulties (HP:0002880)2.86095268
34Leukodystrophy (HP:0002415)2.82432063
35Pancreatic cysts (HP:0001737)2.82142680
36Optic disc pallor (HP:0000543)2.80402712
37Methylmalonic aciduria (HP:0012120)2.74520910
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.64453315
39Abnormality of midbrain morphology (HP:0002418)2.60360819
40Molar tooth sign on MRI (HP:0002419)2.60360819
41Aplastic anemia (HP:0001915)2.56123623
42Medial flaring of the eyebrow (HP:0010747)2.55103395
43Reticulocytopenia (HP:0001896)2.51099842
44Reduced antithrombin III activity (HP:0001976)2.43719871
45Recurrent abscess formation (HP:0002722)2.42011677
46Hyperglycinemia (HP:0002154)2.38327712
47Recurrent bacterial skin infections (HP:0005406)2.35976475
48Metaphyseal dysplasia (HP:0100255)2.34767097
49CNS demyelination (HP:0007305)2.32943691
50Abnormality of vitamin B metabolism (HP:0004340)2.32598428
51Abnormality of serum amino acid levels (HP:0003112)2.30939095
52Hypoglycemic coma (HP:0001325)2.30804978
53Generalized aminoaciduria (HP:0002909)2.29512809
54Abnormality of the renal cortex (HP:0011035)2.29211071
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28396895
56Abnormality of alanine metabolism (HP:0010916)2.27039751
57Hyperalaninemia (HP:0003348)2.27039751
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27039751
59Abnormality of methionine metabolism (HP:0010901)2.24200174
60Abnormality of the anterior horn cell (HP:0006802)2.22492075
61Degeneration of anterior horn cells (HP:0002398)2.22492075
62Hypoplasia of the fovea (HP:0007750)2.22424170
63Aplasia/Hypoplasia of the fovea (HP:0008060)2.22424170
64Abnormality of renal resorption (HP:0011038)2.21790997
65Breast hypoplasia (HP:0003187)2.21022086
66Hypothermia (HP:0002045)2.20704613
67Abnormality of the labia minora (HP:0012880)2.20429965
68Macrocytic anemia (HP:0001972)2.18229804
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.16854753
70Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15917638
71Absent epiphyses (HP:0010577)2.15917638
72Microvesicular hepatic steatosis (HP:0001414)2.15304845
73Abnormality of urine glucose concentration (HP:0011016)2.15239075
74Glycosuria (HP:0003076)2.15239075
75Nausea (HP:0002018)2.13859594
76Lethargy (HP:0001254)2.12892355
77Poor head control (HP:0002421)2.11392948
78Cerebral hypomyelination (HP:0006808)2.10833596
79Aplasia/Hypoplasia of the uvula (HP:0010293)2.09196303
80Meckel diverticulum (HP:0002245)2.08622994
81Carpal bone hypoplasia (HP:0001498)2.05608324
82Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03897756
83Congenital stationary night blindness (HP:0007642)2.02640279
84Intestinal atresia (HP:0011100)2.00954647
85Abnormality of chromosome stability (HP:0003220)2.00481599
86Abnormality of the fovea (HP:0000493)1.99767769
87Abnormality of the ileum (HP:0001549)1.99292417
88Abnormality of the vitamin B12 metabolism (HP:0004341)1.99126565
89Nephronophthisis (HP:0000090)1.99079173
90Adrenal hypoplasia (HP:0000835)1.96664169
91X-linked dominant inheritance (HP:0001423)1.96017286
92Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95032620
93Abolished electroretinogram (ERG) (HP:0000550)1.94938359
94Congenital primary aphakia (HP:0007707)1.94550121
95Hypoplastic left heart (HP:0004383)1.91778141
96Neuroendocrine neoplasm (HP:0100634)1.90764309
97Multiple enchondromatosis (HP:0005701)1.90760621
98Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.90495289
99Abnormal protein N-linked glycosylation (HP:0012347)1.90495289
100Abnormal protein glycosylation (HP:0012346)1.90495289
101Abnormal glycosylation (HP:0012345)1.90495289
102Gliosis (HP:0002171)1.90267886
103Large for gestational age (HP:0001520)1.88538725
104Nephrogenic diabetes insipidus (HP:0009806)1.87665105
105Chromsome breakage (HP:0040012)1.87204635
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85052656
107Ketoacidosis (HP:0001993)1.84579396
108Abnormality of fatty-acid metabolism (HP:0004359)1.83674604
109Pallor (HP:0000980)1.82874443
110Oral leukoplakia (HP:0002745)1.82450807
111Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81038298
112Dicarboxylic aciduria (HP:0003215)1.81038298
113Abnormality of the preputium (HP:0100587)1.79762996
114Gait imbalance (HP:0002141)1.78068925
115Prolonged neonatal jaundice (HP:0006579)1.77844912
116Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77025222
117Thrombocytosis (HP:0001894)1.73513205
118Colon cancer (HP:0003003)1.72478973
119Renal cortical cysts (HP:0000803)1.71349949
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.70913020
121Parakeratosis (HP:0001036)1.70505666
122Sensory axonal neuropathy (HP:0003390)1.70447568
123Petechiae (HP:0000967)1.70308921
124True hermaphroditism (HP:0010459)1.69852075
125Congenital, generalized hypertrichosis (HP:0004540)1.69628338
126Type 2 muscle fiber atrophy (HP:0003554)1.68649455
127Emotional lability (HP:0000712)1.68083602
128Pancytopenia (HP:0001876)1.68035231
129Rhabdomyolysis (HP:0003201)1.67794769
130Tongue fasciculations (HP:0001308)1.67143880
131Rough bone trabeculation (HP:0100670)1.66886838
132Flat capital femoral epiphysis (HP:0003370)1.66857335
133Aplasia/Hypoplasia of the tibia (HP:0005772)1.66852234
134Metabolic acidosis (HP:0001942)1.66570612
135Hyperinsulinemic hypoglycemia (HP:0000825)1.65667658
136Blindness (HP:0000618)1.65654593
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65420075
138Hypoplastic heart (HP:0001961)1.63538664
139Pancreatic fibrosis (HP:0100732)1.62803366
140Respiratory distress (HP:0002098)1.62423352
141Short middle phalanx of the 5th finger (HP:0004220)1.62008514
142Abnormality of the femoral head (HP:0003368)1.57820144
143Palpitations (HP:0001962)1.57731353
144Microretrognathia (HP:0000308)1.57226927
145Proximal tubulopathy (HP:0000114)1.55577285
146Neoplasm of the adrenal gland (HP:0100631)1.54982276
147Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.53176066
148Hepatosplenomegaly (HP:0001433)1.52859919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.62053623
2FRK3.52458173
3EIF2AK13.39295848
4BUB13.26620696
5PBK3.07050186
6STK162.91399233
7EIF2AK32.77529168
8MAP4K22.49043594
9PIM22.46280956
10VRK12.37649513
11WEE12.36580265
12VRK22.26313052
13NEK12.21995607
14PINK12.19300275
15MYLK2.16752256
16MST42.15807385
17WNK32.03929364
18TRIM281.84110418
19CDC71.78845869
20ZAK1.75085512
21BRSK21.69170664
22CDK81.67374050
23BMPR1B1.66755224
24GRK11.65212974
25MUSK1.65136576
26OBSCN1.61133495
27SRPK11.59229188
28NME11.58904600
29BCKDK1.57751523
30PLK41.54127752
31ACVR1B1.54032312
32LIMK11.53788828
33CCNB11.50907893
34MKNK11.44537391
35IRAK41.41795970
36MAP3K141.39920249
37EIF2AK21.39120040
38ARAF1.34116566
39ABL21.32897112
40TEC1.30488054
41TTK1.28095808
42MAP3K41.19871889
43PHKG11.16407065
44PHKG21.16407065
45TLK11.12749457
46STK38L1.12528711
47STK241.12269288
48INSRR1.07739743
49MAP3K121.06992699
50BMPR21.05804102
51CSNK1G11.05765584
52IRAK31.04804173
53STK31.00791713
54OXSR11.00041601
55BCR0.99018865
56MARK30.98300439
57KIT0.96109008
58PDK20.94957639
59PLK30.94011612
60BRSK10.93953036
61TAOK30.93663780
62MKNK20.92366757
63PLK10.91944756
64DYRK20.89689393
65IKBKB0.89110803
66BLK0.88625993
67ILK0.86860554
68AURKB0.86599646
69STK40.86327362
70DYRK30.85678856
71ADRBK20.85023797
72BRAF0.83473175
73TAF10.82708204
74PIK3CG0.82255642
75CSNK1G20.81569585
76KDR0.80862403
77PDK30.80634542
78PDK40.80634542
79TESK20.80103784
80NUAK10.76446514
81TGFBR10.75534910
82WNK40.74244843
83CSNK2A10.73737563
84DAPK10.73383355
85CASK0.72807972
86PAK30.72135003
87RPS6KA40.70750310
88CSNK1A1L0.70669868
89TRPM70.67299692
90NEK90.65845270
91PIM10.62516266
92YES10.60676758
93TSSK60.60463753
94AURKA0.60301879
95TBK10.59938233
96ATR0.57410903
97TESK10.55346385
98MAPK130.53597787
99MAPKAPK50.52033378
100LYN0.51910777
101TYK20.51678740
102PRKCE0.51492514
103CDK70.51403786
104ATM0.51229913
105PRKCI0.50404095
106CDK190.48436755
107CSNK2A20.48202532
108RPS6KA50.47966942
109TIE10.47942130
110MAPKAPK30.47707679
111CHEK20.47165616
112PAK10.46400035
113MAP2K70.44476558
114DAPK20.43336408
115STK390.43241723
116CAMK2D0.43220648
117TXK0.42191918
118FER0.41982410
119PLK20.41650272
120BTK0.41115755
121PRKCD0.41037070
122CSNK1G30.40482002
123TNIK0.40122680
124FLT30.39782404
125ADRBK10.39760607
126TAOK20.39043499
127CDK30.38349359
128MAP3K60.38221146
129LRRK20.36915645
130JAK30.36413590
131CSNK1A10.35056066
132DAPK30.34675029
133ERBB30.33772070
134MAPK40.33402333
135ERBB40.33188388
136GRK70.32621305
137CAMKK20.31977109
138PRKCG0.31518439
139PRKCQ0.30318281

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37462759
2Oxidative phosphorylation_Homo sapiens_hsa001903.97221730
3Ribosome_Homo sapiens_hsa030103.77913663
4Parkinsons disease_Homo sapiens_hsa050123.65487071
5DNA replication_Homo sapiens_hsa030303.18935812
6Protein export_Homo sapiens_hsa030602.97746220
7RNA polymerase_Homo sapiens_hsa030202.89253547
8Huntingtons disease_Homo sapiens_hsa050162.62232808
9Mismatch repair_Homo sapiens_hsa034302.57959925
10Alzheimers disease_Homo sapiens_hsa050102.47076280
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34871533
12Pyrimidine metabolism_Homo sapiens_hsa002402.19612833
13Homologous recombination_Homo sapiens_hsa034402.19145427
14Nucleotide excision repair_Homo sapiens_hsa034202.04076455
15Base excision repair_Homo sapiens_hsa034101.97412065
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84195239
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77962936
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76386510
19Spliceosome_Homo sapiens_hsa030401.71407822
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.66563500
21Butanoate metabolism_Homo sapiens_hsa006501.60922235
22Non-homologous end-joining_Homo sapiens_hsa034501.55691495
23Basal transcription factors_Homo sapiens_hsa030221.52582821
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.45241459
25Cardiac muscle contraction_Homo sapiens_hsa042601.41111543
26Folate biosynthesis_Homo sapiens_hsa007901.38361461
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31248114
28RNA transport_Homo sapiens_hsa030131.28583933
29Fanconi anemia pathway_Homo sapiens_hsa034601.22578914
30Allograft rejection_Homo sapiens_hsa053301.22207138
31Glutathione metabolism_Homo sapiens_hsa004801.21687948
32RNA degradation_Homo sapiens_hsa030181.21100978
33Purine metabolism_Homo sapiens_hsa002301.17928458
34Tryptophan metabolism_Homo sapiens_hsa003801.17285775
35Collecting duct acid secretion_Homo sapiens_hsa049661.16831622
36Fatty acid elongation_Homo sapiens_hsa000621.15904550
37Cell cycle_Homo sapiens_hsa041101.15005222
38One carbon pool by folate_Homo sapiens_hsa006701.13286998
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10918120
40Nitrogen metabolism_Homo sapiens_hsa009101.10708183
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.10409073
42Sulfur metabolism_Homo sapiens_hsa009201.04950767
43Caffeine metabolism_Homo sapiens_hsa002321.02064508
44Phototransduction_Homo sapiens_hsa047441.00190660
45Propanoate metabolism_Homo sapiens_hsa006400.97182432
46Legionellosis_Homo sapiens_hsa051340.93709663
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87808414
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87201341
49Carbon metabolism_Homo sapiens_hsa012000.86345060
50Graft-versus-host disease_Homo sapiens_hsa053320.85654854
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85356163
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84543928
53Steroid biosynthesis_Homo sapiens_hsa001000.83969284
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79140420
55Fatty acid metabolism_Homo sapiens_hsa012120.78468682
56* Metabolic pathways_Homo sapiens_hsa011000.78420076
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78147141
58Arachidonic acid metabolism_Homo sapiens_hsa005900.76598515
59Peroxisome_Homo sapiens_hsa041460.76290776
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74808337
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74630496
62Pyruvate metabolism_Homo sapiens_hsa006200.72917087
63* Cysteine and methionine metabolism_Homo sapiens_hsa002700.72728573
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71860135
65Autoimmune thyroid disease_Homo sapiens_hsa053200.70864043
66Asthma_Homo sapiens_hsa053100.70594751
67p53 signaling pathway_Homo sapiens_hsa041150.68729882
68Epstein-Barr virus infection_Homo sapiens_hsa051690.67996075
69beta-Alanine metabolism_Homo sapiens_hsa004100.66841088
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65714190
71Rheumatoid arthritis_Homo sapiens_hsa053230.64684324
72Pentose phosphate pathway_Homo sapiens_hsa000300.64455833
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.64070914
74Arginine and proline metabolism_Homo sapiens_hsa003300.60573062
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.58990045
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58673784
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58303324
78Biosynthesis of amino acids_Homo sapiens_hsa012300.57809795
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57744329
80Herpes simplex infection_Homo sapiens_hsa051680.57028597
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.56980715
82Malaria_Homo sapiens_hsa051440.56939152
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55074864
84Type I diabetes mellitus_Homo sapiens_hsa049400.54369821
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53861106
86Retinol metabolism_Homo sapiens_hsa008300.49830891
87Systemic lupus erythematosus_Homo sapiens_hsa053220.49013008
88Oocyte meiosis_Homo sapiens_hsa041140.48030615
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47825367
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47756379
91Linoleic acid metabolism_Homo sapiens_hsa005910.47367958
92Sulfur relay system_Homo sapiens_hsa041220.47054266
93Other glycan degradation_Homo sapiens_hsa005110.46851551
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43545632
95Ether lipid metabolism_Homo sapiens_hsa005650.43479797
96Mineral absorption_Homo sapiens_hsa049780.42663154
97Galactose metabolism_Homo sapiens_hsa000520.41097598
98Leishmaniasis_Homo sapiens_hsa051400.40410083
99Phagosome_Homo sapiens_hsa041450.40148804
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40134406
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39527938
102Olfactory transduction_Homo sapiens_hsa047400.39187974
103Circadian rhythm_Homo sapiens_hsa047100.39030943
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38134153
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36236210
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35902635
107Vitamin B6 metabolism_Homo sapiens_hsa007500.35777273
108Regulation of autophagy_Homo sapiens_hsa041400.35630066
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34772719
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34587861
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33747218
112N-Glycan biosynthesis_Homo sapiens_hsa005100.32362347
113Pertussis_Homo sapiens_hsa051330.32014051
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31898290
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31734356
116Fatty acid degradation_Homo sapiens_hsa000710.30841917
117Tyrosine metabolism_Homo sapiens_hsa003500.30376526
118Measles_Homo sapiens_hsa051620.29603967
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29387409
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29094423
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29027375
122Selenocompound metabolism_Homo sapiens_hsa004500.27966227
123Viral myocarditis_Homo sapiens_hsa054160.27592203
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27506993
125Chemical carcinogenesis_Homo sapiens_hsa052040.26940647
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26431651
127Hematopoietic cell lineage_Homo sapiens_hsa046400.26081731

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