APEH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)5.41769855
2lysine catabolic process (GO:0006554)5.41769855
3L-phenylalanine metabolic process (GO:0006558)5.17160363
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.17160363
5L-phenylalanine catabolic process (GO:0006559)5.08858098
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.08858098
7cysteine metabolic process (GO:0006534)5.07495395
8glyoxylate metabolic process (GO:0046487)5.00653582
9proline biosynthetic process (GO:0006561)4.93997760
10COPI coating of Golgi vesicle (GO:0048205)4.82303898
11Golgi transport vesicle coating (GO:0048200)4.82303898
12aromatic amino acid family catabolic process (GO:0009074)4.72628888
13regulation of translational fidelity (GO:0006450)4.67492046
14DNA unwinding involved in DNA replication (GO:0006268)4.45814271
15sulfur amino acid catabolic process (GO:0000098)4.45598054
16tryptophan catabolic process (GO:0006569)4.42331627
17indole-containing compound catabolic process (GO:0042436)4.42331627
18indolalkylamine catabolic process (GO:0046218)4.42331627
19formation of translation preinitiation complex (GO:0001731)4.36747888
20L-serine metabolic process (GO:0006563)4.34343233
21kynurenine metabolic process (GO:0070189)4.31671300
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30821305
23protoporphyrinogen IX metabolic process (GO:0046501)4.28149416
24drug transmembrane transport (GO:0006855)4.27510114
25urate metabolic process (GO:0046415)4.26211584
26valine metabolic process (GO:0006573)4.25568560
27establishment of integrated proviral latency (GO:0075713)4.24928117
28tryptophan metabolic process (GO:0006568)4.19978198
29peptidyl-arginine omega-N-methylation (GO:0035247)4.09129553
30protoporphyrinogen IX biosynthetic process (GO:0006782)4.07003788
31triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.06220328
32alpha-linolenic acid metabolic process (GO:0036109)4.00674424
33serine family amino acid catabolic process (GO:0009071)4.00549560
34DNA strand elongation involved in DNA replication (GO:0006271)3.93726833
35drug transport (GO:0015893)3.92240897
36glycine metabolic process (GO:0006544)3.92036199
372-oxoglutarate metabolic process (GO:0006103)3.90873613
38serine family amino acid metabolic process (GO:0009069)3.89372062
39urea cycle (GO:0000050)3.86072756
40urea metabolic process (GO:0019627)3.86072756
41homocysteine metabolic process (GO:0050667)3.84070313
42NADH metabolic process (GO:0006734)3.82624401
43DNA strand elongation (GO:0022616)3.81748937
44tricarboxylic acid metabolic process (GO:0072350)3.80720209
45amino-acid betaine metabolic process (GO:0006577)3.79975237
46serine family amino acid biosynthetic process (GO:0009070)3.79694862
47heme biosynthetic process (GO:0006783)3.79255827
48protein maturation by protein folding (GO:0022417)3.75894024
49mitotic chromosome condensation (GO:0007076)3.74114937
50bile acid biosynthetic process (GO:0006699)3.73867797
51ethanol oxidation (GO:0006069)3.67420842
52cellular modified amino acid catabolic process (GO:0042219)3.60917766
53histone arginine methylation (GO:0034969)3.58931386
54nitrogen cycle metabolic process (GO:0071941)3.57355868
55ribosomal small subunit biogenesis (GO:0042274)3.55050527
56establishment of viral latency (GO:0019043)3.53943796
57telomere maintenance via semi-conservative replication (GO:0032201)3.53275288
58negative regulation of fibrinolysis (GO:0051918)3.50429699
59heme metabolic process (GO:0042168)3.50416813
60glucose catabolic process (GO:0006007)3.49413919
61short-chain fatty acid metabolic process (GO:0046459)3.49135955
62drug catabolic process (GO:0042737)3.45764632
63regulation of cholesterol homeostasis (GO:2000188)3.45761494
64aspartate family amino acid catabolic process (GO:0009068)3.45045808
65alpha-amino acid catabolic process (GO:1901606)3.44949843
66aromatic amino acid family metabolic process (GO:0009072)3.43033208
67porphyrin-containing compound biosynthetic process (GO:0006779)3.42095736
68protein complex localization (GO:0031503)3.38956665
69negative regulation of sterol transport (GO:0032372)3.34453569
70negative regulation of cholesterol transport (GO:0032375)3.34453569
71fatty acid beta-oxidation (GO:0006635)3.32494324
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.29516121
73antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.29516121
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28825309
75high-density lipoprotein particle remodeling (GO:0034375)3.28588584
76cellular amino acid catabolic process (GO:0009063)3.28340600
77plasma lipoprotein particle assembly (GO:0034377)3.27291995
78protein carboxylation (GO:0018214)3.24826774
79peptidyl-glutamic acid carboxylation (GO:0017187)3.24826774
80nucleobase-containing small molecule interconversion (GO:0015949)3.23680717
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23556821
82peptidyl-arginine N-methylation (GO:0035246)3.22537132
83peptidyl-arginine methylation (GO:0018216)3.22537132
84fatty acid oxidation (GO:0019395)3.22066678
85tricarboxylic acid cycle (GO:0006099)3.21327077
86pentose metabolic process (GO:0019321)3.18857065
87porphyrin-containing compound metabolic process (GO:0006778)3.17611331
88carnitine metabolic process (GO:0009437)3.17314060
89heterochromatin organization (GO:0070828)3.15282565
90lipid oxidation (GO:0034440)3.15226347
91cellular ketone body metabolic process (GO:0046950)3.15127212
92response to mercury ion (GO:0046689)3.13939116
93regulation of triglyceride catabolic process (GO:0010896)3.13377123
94IMP biosynthetic process (GO:0006188)3.10728197
95acetyl-CoA metabolic process (GO:0006084)3.10504971
96flavonoid metabolic process (GO:0009812)3.10124679
97folic acid-containing compound biosynthetic process (GO:0009396)3.08931727
98protein retention in ER lumen (GO:0006621)3.08339848
99regulation of protein activation cascade (GO:2000257)3.08167735
100bile acid metabolic process (GO:0008206)3.08051413
101branched-chain amino acid metabolic process (GO:0009081)3.08011323
102GDP-mannose metabolic process (GO:0019673)3.07860878
103oxaloacetate metabolic process (GO:0006107)3.07592057
104tetrapyrrole biosynthetic process (GO:0033014)3.07188824
105mitochondrial fusion (GO:0008053)3.06658942
106complement activation, alternative pathway (GO:0006957)3.06144266
107reverse cholesterol transport (GO:0043691)3.04120847
108glutamate metabolic process (GO:0006536)3.03430201
109regulation of fibrinolysis (GO:0051917)3.03424280
110indolalkylamine metabolic process (GO:0006586)3.02939736
111DNA replication initiation (GO:0006270)3.01505344
112organic acid catabolic process (GO:0016054)3.00714332
113carboxylic acid catabolic process (GO:0046395)3.00714332
114fatty acid catabolic process (GO:0009062)3.00337844
115exogenous drug catabolic process (GO:0042738)3.00035377
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00012043
117monosaccharide biosynthetic process (GO:0046364)2.99431129
118protein-lipid complex assembly (GO:0065005)2.99184642
119benzene-containing compound metabolic process (GO:0042537)2.98874510
120pentose-phosphate shunt (GO:0006098)2.98613737
121phospholipid efflux (GO:0033700)2.98360083
122folic acid metabolic process (GO:0046655)2.97696125
123aldehyde catabolic process (GO:0046185)2.97047099
124monocarboxylic acid catabolic process (GO:0072329)2.95135265
125tRNA aminoacylation for protein translation (GO:0006418)2.95087359
126regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94070456
127regulation of cholesterol esterification (GO:0010872)2.93017723
128ribosomal small subunit assembly (GO:0000028)2.91575597
129regulation of complement activation (GO:0030449)2.89587948
130regulation of mitochondrial translation (GO:0070129)2.88488391
131oxidative phosphorylation (GO:0006119)2.88487299
132viral transcription (GO:0019083)2.88171469
133IMP metabolic process (GO:0046040)2.88139145
134mitochondrial DNA metabolic process (GO:0032042)2.87720623
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.87419152
136ribosomal large subunit biogenesis (GO:0042273)2.86839470
137proline metabolic process (GO:0006560)2.85321257
138regulation of translational termination (GO:0006449)2.85159902
139protein-lipid complex remodeling (GO:0034368)2.82769437
140macromolecular complex remodeling (GO:0034367)2.82769437
141plasma lipoprotein particle remodeling (GO:0034369)2.82769437
142cellular biogenic amine catabolic process (GO:0042402)2.82186315
143amine catabolic process (GO:0009310)2.82186315
144NADPH regeneration (GO:0006740)2.82050149
145nuclear pore complex assembly (GO:0051292)2.81784610
146telomere maintenance via recombination (GO:0000722)2.81532324
147plasma lipoprotein particle clearance (GO:0034381)2.81361903
148antigen processing and presentation of endogenous antigen (GO:0019883)2.80681401
149amino acid activation (GO:0043038)2.80301858
150tRNA aminoacylation (GO:0043039)2.80301858
151cellular glucuronidation (GO:0052695)2.78985731
152one-carbon metabolic process (GO:0006730)2.78092218
153maturation of SSU-rRNA (GO:0030490)2.77708331
154mitotic sister chromatid segregation (GO:0000070)2.75536124
155cellular protein complex localization (GO:0034629)2.75073926
156gluconeogenesis (GO:0006094)2.75066801
157L-alpha-amino acid transmembrane transport (GO:1902475)2.74975803
158glucose 6-phosphate metabolic process (GO:0051156)2.74770005
159ribonucleoprotein complex biogenesis (GO:0022613)2.73825576
160translational termination (GO:0006415)2.72043761
161biotin metabolic process (GO:0006768)2.71047439
162translational elongation (GO:0006414)2.70910728
163hexose biosynthetic process (GO:0019319)2.70720179
164mitotic nuclear envelope disassembly (GO:0007077)2.69678358
165nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.67913569
166mitotic recombination (GO:0006312)2.65688419
167deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65398808
168nuclear envelope reassembly (GO:0031468)2.64029165
169mitotic nuclear envelope reassembly (GO:0007084)2.64029165
170glutamine family amino acid biosynthetic process (GO:0009084)2.63620963
171DNA duplex unwinding (GO:0032508)2.60378744
172protein localization to chromosome, centromeric region (GO:0071459)2.59485975
173rRNA transcription (GO:0009303)2.55511602
174SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.54471428
175ncRNA 3-end processing (GO:0043628)2.54272777
176nucleobase biosynthetic process (GO:0046112)2.52922754
177glycolytic process (GO:0006096)2.52380974
178NADP metabolic process (GO:0006739)2.52033416
179base-excision repair (GO:0006284)2.51794826
180folic acid-containing compound metabolic process (GO:0006760)2.51765491
181translational initiation (GO:0006413)2.51745010
182ribosome biogenesis (GO:0042254)2.50062875
183ribosome assembly (GO:0042255)2.48772654
184protein targeting to ER (GO:0045047)2.47785333
185cotranslational protein targeting to membrane (GO:0006613)2.46762997
186pteridine-containing compound biosynthetic process (GO:0042559)2.46708733
187nuclear envelope disassembly (GO:0051081)2.44900457
188membrane disassembly (GO:0030397)2.44900457
189maternal placenta development (GO:0001893)2.44608490
190negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44331419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.10671029
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.10212174
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.84603795
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.54429300
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49362124
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.00033394
7E2F7_22180533_ChIP-Seq_HELA_Human2.89189637
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.89059575
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.84976164
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.80101601
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.60873010
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.43978555
13MYC_22102868_ChIP-Seq_BL_Human2.13103031
14GATA1_22025678_ChIP-Seq_K562_Human2.08363542
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05693479
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04250265
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00813170
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.85668915
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84447481
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81803259
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81457366
22SCL_19346495_ChIP-Seq_HPC-7_Human1.78475205
23VDR_21846776_ChIP-Seq_THP-1_Human1.77605185
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.72868109
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.67818966
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66704363
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65179445
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63922139
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62792289
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61616995
31KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61580415
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60440993
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59618251
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59474125
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55237606
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55068215
37* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.53395398
38RACK7_27058665_Chip-Seq_MCF-7_Human1.50695653
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50215793
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49988794
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49874849
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47513158
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47189122
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43991437
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43646074
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42388856
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41842204
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40587291
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40532944
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40240747
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39908980
52TTF2_22483619_ChIP-Seq_HELA_Human1.33381800
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32939486
54MAF_26560356_Chip-Seq_TH1_Human1.32281623
55CLOCK_20551151_ChIP-Seq_293T_Human1.32078551
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.30202634
57* GATA1_19941827_ChIP-Seq_MEL_Mouse1.29493108
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29000590
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28655874
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.26021976
61* LXR_22292898_ChIP-Seq_THP-1_Human1.24517734
62UTX_26944678_Chip-Seq_JUKART_Human1.24124406
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22376459
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21834934
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.21693143
66KDM5A_27292631_Chip-Seq_BREAST_Human1.21469796
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.21345648
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20119376
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20010544
70SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19665579
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19283327
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18787660
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.18115587
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18019209
75MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17925777
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17461825
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17459510
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16755894
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16465270
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15597850
81XRN2_22483619_ChIP-Seq_HELA_Human1.15514391
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15181123
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14421282
84CIITA_25753668_ChIP-Seq_RAJI_Human1.13641047
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.12565480
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.12117728
87TCF7_22412390_ChIP-Seq_EML_Mouse1.12060552
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11777452
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11661615
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10757573
91RUNX1_22412390_ChIP-Seq_EML_Mouse1.10333019
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10216676
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10097472
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09520178
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09187998
96ATF3_27146783_Chip-Seq_COLON_Human1.08855485
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.08057488
98ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08020158
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07751429
100GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07189139
101* P68_20966046_ChIP-Seq_HELA_Human1.06865065
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06727683
103GATA1_19941826_ChIP-Seq_K562_Human1.06498786
104FOXP3_21729870_ChIP-Seq_TREG_Human1.06031942
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05279566
106MYB_26560356_Chip-Seq_TH1_Human1.04830204
107NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04516855
108AR_21909140_ChIP-Seq_LNCAP_Human1.04420759
109CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.03802696
110TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03617418
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03600301
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03532969
113TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02903352
114MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02796587
115* GABP_19822575_ChIP-Seq_HepG2_Human1.01188083
116VDR_24763502_ChIP-Seq_THP-1_Human1.01062057
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00416961
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99641538
119GABP_17652178_ChIP-ChIP_JURKAT_Human0.99327498
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99245010
121E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99140716
122* SPI1_23547873_ChIP-Seq_NB4_Human0.98754184
123BCL6_27268052_Chip-Seq_Bcells_Human0.98595022
124CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98342048
125* MAF_26560356_Chip-Seq_TH2_Human0.97819180
126CHD1_26751641_Chip-Seq_LNCaP_Human0.97456651
127CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97331849
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96839574
129IRF8_21731497_ChIP-ChIP_J774_Mouse0.95366665
130STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95309728
131FOXP1_21924763_ChIP-Seq_HESCs_Human0.94913154
132LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94813744
133DCP1A_22483619_ChIP-Seq_HELA_Human0.93680667
134* MYB_26560356_Chip-Seq_TH2_Human0.93369566
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92933844
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92471603
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.92375772
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91919374
139FOXM1_23109430_ChIP-Seq_U2OS_Human0.91556716
140MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91279497
141EST1_17652178_ChIP-ChIP_JURKAT_Human0.90608815
142ZNF263_19887448_ChIP-Seq_K562_Human0.90597852
143TFEB_21752829_ChIP-Seq_HELA_Human0.90014750
144* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89102222
145* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88917467
146VDR_23849224_ChIP-Seq_CD4+_Human0.88643409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.01006827
2MP0002139_abnormal_hepatobiliary_system5.55616727
3MP0005365_abnormal_bile_salt3.97848289
4MP0005085_abnormal_gallbladder_physiolo3.83714106
5MP0003806_abnormal_nucleotide_metabolis3.55991841
6MP0008875_abnormal_xenobiotic_pharmacok3.30656983
7MP0003111_abnormal_nucleus_morphology3.17899981
8MP0010234_abnormal_vibrissa_follicle3.16629638
9MP0004957_abnormal_blastocyst_morpholog3.05476597
10MP0003656_abnormal_erythrocyte_physiolo2.79836853
11MP0009840_abnormal_foam_cell2.71743755
12MP0010094_abnormal_chromosome_stability2.69486042
13MP0001849_ear_inflammation2.61748897
14MP0008260_abnormal_autophagy2.58080468
15MP0003252_abnormal_bile_duct2.56933289
16MP0005332_abnormal_amino_acid2.56830495
17MP0005083_abnormal_biliary_tract2.53575965
18MP0004233_abnormal_muscle_weight2.52169801
19MP0003077_abnormal_cell_cycle2.36491866
20MP0000537_abnormal_urethra_morphology2.32062991
21MP0010329_abnormal_lipoprotein_level2.32024684
22MP0008932_abnormal_embryonic_tissue2.31775504
23MP0001730_embryonic_growth_arrest2.29794697
24MP0001666_abnormal_nutrient_absorption2.23804582
25MP0004147_increased_porphyrin_level2.17389276
26MP0004185_abnormal_adipocyte_glucose2.14979201
27MP0002138_abnormal_hepatobiliary_system2.11370293
28MP0009643_abnormal_urine_homeostasis2.02491681
29MP0003941_abnormal_skin_development2.01169137
30MP0004019_abnormal_vitamin_homeostasis2.00138732
31MP0001661_extended_life_span2.00126262
32MP0002254_reproductive_system_inflammat1.97822102
33MP0003191_abnormal_cellular_cholesterol1.93131268
34MP0004858_abnormal_nervous_system1.92052350
35MP0010030_abnormal_orbit_morphology1.90614267
36MP0000609_abnormal_liver_physiology1.87800254
37MP0002796_impaired_skin_barrier1.86378119
38MP0003566_abnormal_cell_adhesion1.84486713
39MP0005501_abnormal_skin_physiology1.83637776
40MP0003195_calcinosis1.83469536
41MP0005319_abnormal_enzyme/_coenzyme1.78723915
42MP0005636_abnormal_mineral_homeostasis1.73944556
43MP0003186_abnormal_redox_activity1.73673958
44MP0009672_abnormal_birth_weight1.69490312
45MP0008007_abnormal_cellular_replicative1.65851417
46MP0000350_abnormal_cell_proliferation1.60311978
47MP0002080_prenatal_lethality1.55231394
48MP0008058_abnormal_DNA_repair1.53339840
49MP0002877_abnormal_melanocyte_morpholog1.51440804
50MP0001764_abnormal_homeostasis1.49616493
51MP0000685_abnormal_immune_system1.45877942
52MP0006036_abnormal_mitochondrial_physio1.45484969
53MP0001672_abnormal_embryogenesis/_devel1.43257143
54MP0005380_embryogenesis_phenotype1.43257143
55MP0005076_abnormal_cell_differentiation1.43254665
56MP0005584_abnormal_enzyme/coenzyme_acti1.43001945
57MP0003123_paternal_imprinting1.41969856
58MP0003705_abnormal_hypodermis_morpholog1.41160076
59MP0003300_gastrointestinal_ulcer1.36319378
60MP0001835_abnormal_antigen_presentation1.35922420
61MP0000598_abnormal_liver_morphology1.33896737
62MP0003984_embryonic_growth_retardation1.33753320
63MP0002118_abnormal_lipid_homeostasis1.33714952
64MP0005464_abnormal_platelet_physiology1.33414938
65MP0003453_abnormal_keratinocyte_physiol1.31143317
66MP0005058_abnormal_lysosome_morphology1.31082410
67MP0000313_abnormal_cell_death1.29203806
68MP0008469_abnormal_protein_level1.26313237
69MP0002088_abnormal_embryonic_growth/wei1.25381377
70MP0001697_abnormal_embryo_size1.24106198
71MP0000747_muscle_weakness1.23118171
72MP0003436_decreased_susceptibility_to1.21853016
73MP0002136_abnormal_kidney_physiology1.20079631
74MP0003315_abnormal_perineum_morphology1.19855062
75MP0002396_abnormal_hematopoietic_system1.18676911
76MP0001756_abnormal_urination1.16947034
77MP0000358_abnormal_cell_content/1.16656586
78MP0000678_abnormal_parathyroid_gland1.15370158
79MP0000751_myopathy1.15298614
80MP0002085_abnormal_embryonic_tissue1.10193174
81MP0003868_abnormal_feces_composition1.08778228
82MP0006054_spinal_hemorrhage1.08736232
83MP0004043_abnormal_pH_regulation1.07775869
84MP0002086_abnormal_extraembryonic_tissu1.07702615
85MP0009764_decreased_sensitivity_to1.04784625
86MP0005330_cardiomyopathy1.04731323
87MP0005257_abnormal_intraocular_pressure1.04715467
88MP0000579_abnormal_nail_morphology1.04048116
89MP0000858_altered_metastatic_potential1.03936065
90MP0005397_hematopoietic_system_phenotyp1.03762523
91MP0001545_abnormal_hematopoietic_system1.03762523
92MP0005220_abnormal_exocrine_pancreas1.01664163
93MP0000689_abnormal_spleen_morphology1.00904411
94MP0002089_abnormal_postnatal_growth/wei1.00647102
95MP0001216_abnormal_epidermal_layer0.99209029
96MP0005025_abnormal_response_to0.98744253
97MP0002166_altered_tumor_susceptibility0.97691139
98MP0010307_abnormal_tumor_latency0.97417729
99MP0009763_increased_sensitivity_to0.97022732
100MP0005666_abnormal_adipose_tissue0.95387439
101MP0001845_abnormal_inflammatory_respons0.95269075
102MP0001853_heart_inflammation0.93918510
103MP0002060_abnormal_skin_morphology0.93499289
104MP0002722_abnormal_immune_system0.93492687
105MP0009785_altered_susceptibility_to0.93338355
106MP0001800_abnormal_humoral_immune0.92876548
107MP0010155_abnormal_intestine_physiology0.92510368
108MP0005384_cellular_phenotype0.92494609
109MP0005621_abnormal_cell_physiology0.91342299
110MP0000490_abnormal_crypts_of0.90931684
111MP0002084_abnormal_developmental_patter0.90853668
112MP0001873_stomach_inflammation0.90817766
113MP0001765_abnormal_ion_homeostasis0.90664558
114MP0002398_abnormal_bone_marrow0.90389281
115MP0003724_increased_susceptibility_to0.90138392
116MP0009642_abnormal_blood_homeostasis0.89961312
117MP0003763_abnormal_thymus_physiology0.89339511
118MP0005408_hypopigmentation0.86843531
119MP0000566_synostosis0.86449737
120MP0002098_abnormal_vibrissa_morphology0.86338111
121MP0008961_abnormal_basal_metabolism0.86201250
122MP0005670_abnormal_white_adipose0.85951135
123MP0002269_muscular_atrophy0.84785849
124MP0002019_abnormal_tumor_incidence0.84613386
125MP0002697_abnormal_eye_size0.84562363
126MP0004264_abnormal_extraembryonic_tissu0.83943771
127MP0010352_gastrointestinal_tract_polyps0.83735106
128MP0003786_premature_aging0.83691821
129MP0000377_abnormal_hair_follicle0.83323672
130MP0009333_abnormal_splenocyte_physiolog0.83210917
131MP0004947_skin_inflammation0.83067449
132MP0004272_abnormal_basement_membrane0.82937570
133MP0004197_abnormal_fetal_growth/weight/0.82736859
134MP0002429_abnormal_blood_cell0.82457908
135MP0005084_abnormal_gallbladder_morpholo0.81849936
136MP0003011_delayed_dark_adaptation0.81658632
137MP0001881_abnormal_mammary_gland0.81454549
138MP0005451_abnormal_body_composition0.80365513
139MP0001790_abnormal_immune_system0.80163636
140MP0005387_immune_system_phenotype0.80163636
141MP0003172_abnormal_lysosome_physiology0.78953312
142MP0009931_abnormal_skin_appearance0.77662906
143MP0001727_abnormal_embryo_implantation0.76985308
144MP0002111_abnormal_tail_morphology0.75992671
145MP0005671_abnormal_response_to0.75219183
146MP0003718_maternal_effect0.75170522
147MP0002723_abnormal_immune_serum0.74968360
148MP0009379_abnormal_foot_pigmentation0.74483139
149MP0002452_abnormal_antigen_presenting0.74363878
150MP0004087_abnormal_muscle_fiber0.73816706
151MP0000716_abnormal_immune_system0.72901303
152MP0002135_abnormal_kidney_morphology0.71591907
153MP0002132_abnormal_respiratory_system0.71484667
154MP0009278_abnormal_bone_marrow0.71080172
155MP0000477_abnormal_intestine_morphology0.70838059
156MP0002419_abnormal_innate_immunity0.70545802
157MP0008057_abnormal_DNA_replication0.70216010
158MP0006082_CNS_inflammation0.69539742
159MP0005000_abnormal_immune_tolerance0.67992168
160MP0006035_abnormal_mitochondrial_morpho0.67380874
161MP0002078_abnormal_glucose_homeostasis0.67348642
162MP0003693_abnormal_embryo_hatching0.67337396
163MP0002420_abnormal_adaptive_immunity0.67263611
164MP0002405_respiratory_system_inflammati0.67175276
165MP0005376_homeostasis/metabolism_phenot0.67048906
166MP0001819_abnormal_immune_cell0.66791841
167MP0005266_abnormal_metabolism0.66195324
168MP0009765_abnormal_xenobiotic_induced0.66116562
169MP0002928_abnormal_bile_duct0.65795701
170MP0000465_gastrointestinal_hemorrhage0.65259467
171MP0000604_amyloidosis0.63761617
172MP0004808_abnormal_hematopoietic_stem0.63247275
173MP0003866_abnormal_defecation0.62278421
174MP0010368_abnormal_lymphatic_system0.60062010

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.89343922
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.28289178
3Intrahepatic cholestasis (HP:0001406)4.21348775
4Xanthomatosis (HP:0000991)4.14862825
5Abnormality of the heme biosynthetic pathway (HP:0010472)4.04043942
6Deep venous thrombosis (HP:0002625)4.02138768
7Abnormality of glutamine family amino acid metabolism (HP:0010902)3.83469759
8Hyperammonemia (HP:0001987)3.75303112
9Microvesicular hepatic steatosis (HP:0001414)3.74123934
10Ketosis (HP:0001946)3.72984677
11Hypobetalipoproteinemia (HP:0003563)3.70546839
12Hyperbilirubinemia (HP:0002904)3.57383814
13Hyperglycinuria (HP:0003108)3.47581897
14Poikilocytosis (HP:0004447)3.44025104
15Gout (HP:0001997)3.37247831
16Hypoglycemic coma (HP:0001325)3.31825373
17Acanthocytosis (HP:0001927)3.28195325
18Abnormality of fatty-acid metabolism (HP:0004359)3.26686207
19Abnormality of glycine metabolism (HP:0010895)3.20055750
20Abnormality of serine family amino acid metabolism (HP:0010894)3.20055750
21Abnormality of purine metabolism (HP:0004352)3.08777413
22Ketoacidosis (HP:0001993)3.08154597
23Abnormality of nucleobase metabolism (HP:0010932)3.06455527
24Generalized aminoaciduria (HP:0002909)3.05450497
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.05119442
26Progressive muscle weakness (HP:0003323)3.03803457
27Dicarboxylic aciduria (HP:0003215)3.02650649
28Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02650649
29Prolonged partial thromboplastin time (HP:0003645)3.02504810
30Abnormality of pyrimidine metabolism (HP:0004353)3.01811755
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.98989993
32Ragged-red muscle fibers (HP:0003200)2.96395172
33Abnormality of glycolysis (HP:0004366)2.94944688
34Hyperacusis (HP:0010780)2.94251514
35Hyperglycinemia (HP:0002154)2.93793780
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86607983
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85183688
38Reticulocytosis (HP:0001923)2.83860915
39Hyperlipoproteinemia (HP:0010980)2.82156060
40Joint hemorrhage (HP:0005261)2.80691356
41Hepatocellular carcinoma (HP:0001402)2.77424620
42Selective tooth agenesis (HP:0001592)2.74734548
43Hypolipoproteinemia (HP:0010981)2.74378145
44Metabolic acidosis (HP:0001942)2.69648316
45Abnormality of the common coagulation pathway (HP:0010990)2.69289956
46Complement deficiency (HP:0004431)2.65794378
47Proximal tubulopathy (HP:0000114)2.61240384
48Spastic diplegia (HP:0001264)2.60882479
49Delayed CNS myelination (HP:0002188)2.60245403
50Late onset (HP:0003584)2.56163747
51Vertebral compression fractures (HP:0002953)2.53503777
52Achilles tendon contracture (HP:0001771)2.52653230
53Myopathic facies (HP:0002058)2.52293395
54Fat malabsorption (HP:0002630)2.50557110
55Increased serum pyruvate (HP:0003542)2.50113028
56Abnormality of the intrinsic pathway (HP:0010989)2.49290513
57Cholelithiasis (HP:0001081)2.48792052
58Abnormality of reticulocytes (HP:0004312)2.46249819
59Abnormality of transition element cation homeostasis (HP:0011030)2.44608708
60Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43144441
61Trismus (HP:0000211)2.43051964
62Reticulocytopenia (HP:0001896)2.42443916
63Increased serum ferritin (HP:0003281)2.41218838
64Testicular atrophy (HP:0000029)2.40048229
65Abnormality of iron homeostasis (HP:0011031)2.39912504
66Abnormality of the Achilles tendon (HP:0005109)2.39378415
67Abnormal gallbladder morphology (HP:0012437)2.36861505
68Nausea (HP:0002018)2.34220626
69Petechiae (HP:0000967)2.31747578
70Abnormal platelet function (HP:0011869)2.31485000
71Impaired platelet aggregation (HP:0003540)2.31485000
72Rhabdomyolysis (HP:0003201)2.29012813
73Short nail (HP:0001799)2.28639536
74Increased purine levels (HP:0004368)2.28245086
75Hyperuricemia (HP:0002149)2.28245086
76Hypoalphalipoproteinemia (HP:0003233)2.27242492
77Vomiting (HP:0002013)2.26316508
78Insomnia (HP:0100785)2.24170712
79Progressive external ophthalmoplegia (HP:0000590)2.22429968
80Lethargy (HP:0001254)2.21160543
81Polycythemia (HP:0001901)2.20470811
82Increased connective tissue (HP:0009025)2.18731814
83Hydroxyprolinuria (HP:0003080)2.15863891
84Abnormality of proline metabolism (HP:0010907)2.15863891
85Rough bone trabeculation (HP:0100670)2.15555137
86Abnormality of methionine metabolism (HP:0010901)2.14232401
87Glycosuria (HP:0003076)2.14215417
88Abnormality of urine glucose concentration (HP:0011016)2.14215417
89Distal lower limb muscle weakness (HP:0009053)2.13612032
90Flat acetabular roof (HP:0003180)2.12466689
91Autoimmune thrombocytopenia (HP:0001973)2.11047937
92Abnormality of complement system (HP:0005339)2.10829621
93Hypercholesterolemia (HP:0003124)2.09482911
94Exercise-induced myalgia (HP:0003738)2.08802030
95Epistaxis (HP:0000421)2.07694040
96Hypochromic microcytic anemia (HP:0004840)2.04812738
97Pili torti (HP:0003777)2.04557668
98Malnutrition (HP:0004395)2.04499495
99Microcytic anemia (HP:0001935)2.04470785
100Epidermoid cyst (HP:0200040)2.02574960
101Menorrhagia (HP:0000132)2.00704586
102Upper motor neuron abnormality (HP:0002127)1.99751668
103Abnormality of serum amino acid levels (HP:0003112)1.98208448
104Brushfield spots (HP:0001088)1.97707141
105Alkalosis (HP:0001948)1.97304580
106Thrombophlebitis (HP:0004418)1.96953527
107IgM deficiency (HP:0002850)1.96645467
108Broad distal phalanx of finger (HP:0009836)1.95892357
109Abnormal cartilage morphology (HP:0002763)1.95463256
110Gingival bleeding (HP:0000225)1.95120559
111Pancreatitis (HP:0001733)1.94879274
112Distal lower limb amyotrophy (HP:0008944)1.94744160
113Abnormal number of erythroid precursors (HP:0012131)1.94295579
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93670869
115Abnormality of the distal phalanges of the toes (HP:0010182)1.91454531
116Systemic lupus erythematosus (HP:0002725)1.91296073
117Multiple enchondromatosis (HP:0005701)1.91106535
118Cholecystitis (HP:0001082)1.91071394
119Abnormal gallbladder physiology (HP:0012438)1.91071394
120Abnormal hair laboratory examination (HP:0003328)1.90882799
121Vacuolated lymphocytes (HP:0001922)1.89764871
122Esophageal varix (HP:0002040)1.89212703
123Neonatal onset (HP:0003623)1.89007601
124Opisthotonus (HP:0002179)1.88822053
125Back pain (HP:0003418)1.88378152
126Prolonged bleeding time (HP:0003010)1.88202313
127Abnormality of cells of the erythroid lineage (HP:0012130)1.88119891
128Abnormal enzyme/coenzyme activity (HP:0012379)1.86835904
129Long palpebral fissure (HP:0000637)1.86663397
130Premature skin wrinkling (HP:0100678)1.86167624
131Upper limb amyotrophy (HP:0009129)1.86040675
132Distal upper limb amyotrophy (HP:0007149)1.86040675
133Abnormality of the gallbladder (HP:0005264)1.85910279
134Myocardial infarction (HP:0001658)1.84796513
135Cerebral edema (HP:0002181)1.84733382
136Thrombocytosis (HP:0001894)1.84256391
137Abnormality of the umbilical cord (HP:0010881)1.83929658
138Deviation of the thumb (HP:0009603)1.83685033
139Abnormality of the thoracic spine (HP:0100711)1.81204035
140Hypokinesia (HP:0002375)1.80809907
141Pterygium (HP:0001059)1.76263510
142Diaphragmatic weakness (HP:0009113)1.75622866
143Abnormality of the calcaneus (HP:0008364)1.75270123
144Abnormal trabecular bone morphology (HP:0100671)1.74233851
145Proximal placement of thumb (HP:0009623)1.73989279
146Myoglobinuria (HP:0002913)1.72761518
147Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72327614
148Progressive hearing impairment (HP:0001730)1.67729819
149Secondary amenorrhea (HP:0000869)1.67352964
150Spastic paraparesis (HP:0002313)1.66196378
151Premature rupture of membranes (HP:0001788)1.66160385
152Flattened epiphyses (HP:0003071)1.65509007
153Entropion (HP:0000621)1.65349422
154Ulnar bowing (HP:0003031)1.64874290
155Cortical dysplasia (HP:0002539)1.63103646
156Fasciculations (HP:0002380)1.63039978
157Generalized amyotrophy (HP:0003700)1.62821786
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.62811185
159Overriding aorta (HP:0002623)1.59698467
160Abnormalities of placenta or umbilical cord (HP:0001194)1.58847350
161Breast hypoplasia (HP:0003187)1.58029446
162Macrocytic anemia (HP:0001972)1.56790033
163Thoracic kyphosis (HP:0002942)1.55711209
164Decreased activity of mitochondrial respiratory chain (HP:0008972)1.54844413
165Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.54844413
166Increased nuchal translucency (HP:0010880)1.54515437
167Abnormality of carpal bone ossification (HP:0006257)1.53879975
168Athetosis (HP:0002305)1.53661896
169Hand muscle atrophy (HP:0009130)1.52251247
170Termporal pattern (HP:0011008)1.51088259
171Insidious onset (HP:0003587)1.51088259
172Exercise-induced muscle cramps (HP:0003710)1.50183922
173Advanced eruption of teeth (HP:0006288)1.49033470
17411 pairs of ribs (HP:0000878)1.48850537
175Bulbar palsy (HP:0001283)1.48845596
176Seborrheic dermatitis (HP:0001051)1.48759767
177Biconcave vertebral bodies (HP:0004586)1.48526484
178Abnormality of the salivary glands (HP:0010286)1.47658533
179Disproportionate tall stature (HP:0001519)1.47644733
180Osteolytic defects of the hand bones (HP:0009699)1.47382644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.20033080
2ERN13.98092212
3BCKDK3.87985300
4MAP4K13.11583334
5FGFR43.07762594
6TRIB32.94666188
7VRK22.75992602
8PKN22.63068821
9ICK2.50915680
10EEF2K2.47832506
11EPHA22.45444905
12NME22.33070156
13FLT32.32046444
14MAP3K102.31300736
15TYK22.23841005
16PBK2.21432435
17TTK1.96748241
18TAOK31.96213490
19GRK61.92643244
20SIK11.88524545
21LRRK21.83210476
22TBK11.79416581
23SCYL21.71218219
24JAK31.69899629
25KIT1.63637511
26EIF2AK11.60509346
27KDR1.59308192
28STK101.58785875
29MAPK111.57385730
30MAP2K31.56663162
31PRPF4B1.53967228
32TSSK61.48552318
33PTK61.47142555
34ZAP701.45166866
35ARAF1.39495383
36SRPK11.37351685
37TGFBR21.32421166
38BTK1.31606231
39IKBKE1.30460836
40PRKD31.26844705
41TESK11.24384936
42WNK41.24023873
43WNK31.20632636
44TGFBR11.19447761
45ACVR1B1.19174793
46CAMK1D1.14158016
47CSF1R1.12995429
48CDK41.12156389
49NME11.11636377
50MAP3K111.10321089
51PAK41.08325311
52LMTK21.05638241
53PASK1.04044335
54AURKA1.03929231
55RPS6KA41.01244099
56BRSK10.99822978
57JAK20.98526066
58RIPK10.98163125
59MAP2K20.96539021
60NEK10.95305124
61BLK0.91814392
62DYRK30.91479187
63PIM20.89168773
64SYK0.88942513
65DYRK1B0.88252243
66JAK10.88201778
67BRAF0.88114973
68PDK20.87778976
69MAP3K70.87038923
70RPS6KB20.86831833
71CHEK20.85567510
72MAPKAPK30.85557116
73PIM10.83994474
74MAP3K80.83560322
75PIK3CG0.83305840
76MAP3K30.83282490
77TAOK10.82219481
78CDK190.79791503
79MET0.78701764
80TTN0.77299766
81NEK20.77060486
82ATR0.75229164
83ILK0.74844780
84TAF10.74465702
85CDK60.74240683
86WEE10.70570478
87ITK0.67834461
88CDK80.67757867
89BMX0.67090165
90CHEK10.66039137
91MATK0.65930250
92CDK120.65229930
93PLK10.64996135
94TESK20.62432438
95NEK90.59115769
96LYN0.58345638
97EPHB10.57160038
98CAMK1G0.56364990
99CSK0.56084037
100DAPK10.55643005
101STK160.55091816
102TXK0.54828118
103CDK70.53318811
104FGFR30.52175209
105LCK0.51879299
106STK40.50466088
107IKBKB0.49794219
108LIMK10.48430499
109TEC0.46986295
110MTOR0.46917430
111ERBB40.45047172
112PAK10.44630493
113DAPK30.44611773
114PRKCI0.44142439
115CDC70.43375128
116ALK0.42885956
117LATS20.42324812
118ZAK0.41911872
119AURKB0.40725310
120MST1R0.40536931
121PRKAA20.40287678
122VRK10.39618513
123MYLK0.39367727
124CDK90.39130133
125MAPK40.39102653
126CHUK0.38515981
127NTRK10.37872869
128MUSK0.37332149
129PRKG20.37322460
130IRAK30.36501381
131PRKD20.35441636
132PTK20.35399911
133CDK11A0.35013583
134PDPK10.34237592
135ERBB20.34140161
136CDK10.33786690
137RPS6KA60.33451388
138ABL20.33391139
139AKT20.31741669
140TIE10.31154339
141BUB10.29720579
142MAP3K140.29524406
143PDGFRA0.29505257
144MAP2K60.28741420
145MAPK120.26648918
146TAOK20.26580700
147RPS6KL10.26513501
148RPS6KC10.26513501

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33937696
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.06579582
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65354190
4Fatty acid degradation_Homo sapiens_hsa000712.64028189
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54660329
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48314846
7Tryptophan metabolism_Homo sapiens_hsa003802.42136567
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38590265
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.33623151
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25586415
11Arginine biosynthesis_Homo sapiens_hsa002202.15152625
12Nitrogen metabolism_Homo sapiens_hsa009102.14218204
13Propanoate metabolism_Homo sapiens_hsa006402.03989927
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.02877806
15Caffeine metabolism_Homo sapiens_hsa002322.00290213
16Peroxisome_Homo sapiens_hsa041462.00163969
17Selenocompound metabolism_Homo sapiens_hsa004501.85773337
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.85612903
19Butanoate metabolism_Homo sapiens_hsa006501.83803868
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80141642
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75634801
22Folate biosynthesis_Homo sapiens_hsa007901.74481726
23Pyruvate metabolism_Homo sapiens_hsa006201.72004162
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.71311960
25Complement and coagulation cascades_Homo sapiens_hsa046101.70112139
26Sulfur relay system_Homo sapiens_hsa041221.69855156
27Fatty acid metabolism_Homo sapiens_hsa012121.66174469
28Carbon metabolism_Homo sapiens_hsa012001.64010212
29beta-Alanine metabolism_Homo sapiens_hsa004101.60924497
30Biosynthesis of amino acids_Homo sapiens_hsa012301.54773483
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53224056
32PPAR signaling pathway_Homo sapiens_hsa033201.53169746
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45208910
34Spliceosome_Homo sapiens_hsa030401.44726370
35Nucleotide excision repair_Homo sapiens_hsa034201.43691788
36One carbon pool by folate_Homo sapiens_hsa006701.38012434
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.37554403
38Starch and sucrose metabolism_Homo sapiens_hsa005001.34508381
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.32717515
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.32525943
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31865311
42Chemical carcinogenesis_Homo sapiens_hsa052041.29497848
43Histidine metabolism_Homo sapiens_hsa003401.28614185
44Pentose phosphate pathway_Homo sapiens_hsa000301.27337764
45Sulfur metabolism_Homo sapiens_hsa009201.25809015
46Non-homologous end-joining_Homo sapiens_hsa034501.25715839
47Cell cycle_Homo sapiens_hsa041101.24051271
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22767006
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22009034
50RNA transport_Homo sapiens_hsa030131.21234325
51Bile secretion_Homo sapiens_hsa049761.16654771
52ABC transporters_Homo sapiens_hsa020101.16605341
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15341878
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15059761
55Fat digestion and absorption_Homo sapiens_hsa049751.12162211
56Lysine degradation_Homo sapiens_hsa003101.11626419
57Staphylococcus aureus infection_Homo sapiens_hsa051501.06321451
58Phenylalanine metabolism_Homo sapiens_hsa003601.04692360
59DNA replication_Homo sapiens_hsa030301.02802327
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.02325457
61Glutathione metabolism_Homo sapiens_hsa004801.01280722
62Thyroid cancer_Homo sapiens_hsa052161.01232335
63Vitamin digestion and absorption_Homo sapiens_hsa049770.97312481
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95183773
65Retinol metabolism_Homo sapiens_hsa008300.95032833
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94948671
67Arginine and proline metabolism_Homo sapiens_hsa003300.94905655
68Homologous recombination_Homo sapiens_hsa034400.94582627
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92855474
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90310576
71RNA polymerase_Homo sapiens_hsa030200.86555357
72Galactose metabolism_Homo sapiens_hsa000520.82789571
73Fructose and mannose metabolism_Homo sapiens_hsa000510.81843921
74Ribosome_Homo sapiens_hsa030100.80685510
75mRNA surveillance pathway_Homo sapiens_hsa030150.79843565
76Tyrosine metabolism_Homo sapiens_hsa003500.73392643
77Vibrio cholerae infection_Homo sapiens_hsa051100.67344958
78Glycerolipid metabolism_Homo sapiens_hsa005610.65826410
79Chronic myeloid leukemia_Homo sapiens_hsa052200.64622701
80Glycosaminoglycan degradation_Homo sapiens_hsa005310.63810519
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61461770
82Other glycan degradation_Homo sapiens_hsa005110.59843644
83Fatty acid elongation_Homo sapiens_hsa000620.56436797
84Metabolic pathways_Homo sapiens_hsa011000.53638267
85Fatty acid biosynthesis_Homo sapiens_hsa000610.53452079
86Insulin signaling pathway_Homo sapiens_hsa049100.52419457
87Purine metabolism_Homo sapiens_hsa002300.50877512
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50815047
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50668757
90Parkinsons disease_Homo sapiens_hsa050120.48077349
91Pyrimidine metabolism_Homo sapiens_hsa002400.47743135
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45868196
93Mismatch repair_Homo sapiens_hsa034300.45822860
94Vitamin B6 metabolism_Homo sapiens_hsa007500.45490854
95Viral carcinogenesis_Homo sapiens_hsa052030.44336425
96Huntingtons disease_Homo sapiens_hsa050160.42329349
97Primary immunodeficiency_Homo sapiens_hsa053400.41817028
98Endometrial cancer_Homo sapiens_hsa052130.41602635
99Base excision repair_Homo sapiens_hsa034100.41478910
100Fanconi anemia pathway_Homo sapiens_hsa034600.41381739
101Antigen processing and presentation_Homo sapiens_hsa046120.39238697
102Non-small cell lung cancer_Homo sapiens_hsa052230.39179122
103Insulin resistance_Homo sapiens_hsa049310.38630283
104AMPK signaling pathway_Homo sapiens_hsa041520.38601947
105Prion diseases_Homo sapiens_hsa050200.38148674
106Notch signaling pathway_Homo sapiens_hsa043300.37306390
107Small cell lung cancer_Homo sapiens_hsa052220.37018430
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.36499046
109Oxidative phosphorylation_Homo sapiens_hsa001900.33483742
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32953447
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32823140
112Shigellosis_Homo sapiens_hsa051310.32099710
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32039820
114Epstein-Barr virus infection_Homo sapiens_hsa051690.30990099
115Glucagon signaling pathway_Homo sapiens_hsa049220.30225006
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29745780
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29076655
118p53 signaling pathway_Homo sapiens_hsa041150.28179422
119Legionellosis_Homo sapiens_hsa051340.24069211
120Systemic lupus erythematosus_Homo sapiens_hsa053220.23754246
121N-Glycan biosynthesis_Homo sapiens_hsa005100.23579891
122HTLV-I infection_Homo sapiens_hsa051660.23362438
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23149881
124Bladder cancer_Homo sapiens_hsa052190.20083645
125Renin-angiotensin system_Homo sapiens_hsa046140.19486365
126Proteasome_Homo sapiens_hsa030500.19014809
127Lysosome_Homo sapiens_hsa041420.18736247
128Measles_Homo sapiens_hsa051620.17931665
129Herpes simplex infection_Homo sapiens_hsa051680.17635750
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16289900
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15699754
132Leishmaniasis_Homo sapiens_hsa051400.13512148
133Hematopoietic cell lineage_Homo sapiens_hsa046400.12283471
134Apoptosis_Homo sapiens_hsa042100.10825090
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10659137
136Steroid biosynthesis_Homo sapiens_hsa001000.10535746
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.08314297
138Acute myeloid leukemia_Homo sapiens_hsa052210.07396506

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