APCDD1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skin morphogenesis (GO:0043589)6.06398955
2protein heterotrimerization (GO:0070208)5.80497277
3type B pancreatic cell proliferation (GO:0044342)5.65334833
4extracellular fibril organization (GO:0043206)5.63807504
5protein maturation by protein folding (GO:0022417)5.32348469
6substrate-dependent cell migration (GO:0006929)5.03043811
7Golgi transport vesicle coating (GO:0048200)4.88420032
8COPI coating of Golgi vesicle (GO:0048205)4.88420032
9fibril organization (GO:0097435)4.80797162
10endodermal cell differentiation (GO:0035987)4.69413692
11protein retention in ER lumen (GO:0006621)4.67501558
12sequestering of extracellular ligand from receptor (GO:0035581)4.54880961
13cell adhesion mediated by integrin (GO:0033627)4.51721145
14collagen fibril organization (GO:0030199)4.51068753
15kidney mesenchyme development (GO:0072074)4.49949188
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.49362213
17muscle cell migration (GO:0014812)4.31502398
18regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.29512613
19actin filament depolymerization (GO:0030042)4.19461252
20chondrocyte proliferation (GO:0035988)4.10328279
21response to gravity (GO:0009629)4.09436095
22regulation of metalloenzyme activity (GO:0048552)3.96770597
23mesodermal cell differentiation (GO:0048333)3.96535359
24barbed-end actin filament capping (GO:0051016)3.96071682
25adhesion of symbiont to host cell (GO:0044650)3.90390292
26virion attachment to host cell (GO:0019062)3.90390292
27cellular response to vitamin (GO:0071295)3.82911175
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.76891808
29negative regulation of smooth muscle cell migration (GO:0014912)3.70490473
30protein localization to endosome (GO:0036010)3.61421940
31metanephric mesenchyme development (GO:0072075)3.58052020
32membrane raft organization (GO:0031579)3.56850578
33hemidesmosome assembly (GO:0031581)3.54833833
34cellular response to vitamin D (GO:0071305)3.54820525
35pattern specification involved in kidney development (GO:0061004)3.53739094
36negative regulation of chondrocyte differentiation (GO:0032331)3.53632366
37wound healing, spreading of epidermal cells (GO:0035313)3.51667345
38nuclear envelope reassembly (GO:0031468)3.47676631
39mitotic nuclear envelope reassembly (GO:0007084)3.47676631
40peptidyl-proline hydroxylation (GO:0019511)3.41662964
41cell migration involved in sprouting angiogenesis (GO:0002042)3.41476675
42glomerular visceral epithelial cell development (GO:0072015)3.41333008
43protein hydroxylation (GO:0018126)3.38933741
44extracellular matrix assembly (GO:0085029)3.34097255
45endothelial cell morphogenesis (GO:0001886)3.34074613
46collagen metabolic process (GO:0032963)3.32365455
47regulation of integrin-mediated signaling pathway (GO:2001044)3.26377893
48positive regulation of blood vessel endothelial cell migration (GO:0043536)3.24747020
49dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.23846224
50endocardial cushion development (GO:0003197)3.18665826
51adhesion of symbiont to host (GO:0044406)3.17859253
52endocytic recycling (GO:0032456)3.16144607
53extracellular regulation of signal transduction (GO:1900115)3.12833560
54extracellular negative regulation of signal transduction (GO:1900116)3.12833560
55negative regulation of nitric-oxide synthase activity (GO:0051001)3.09460791
56regulation of smooth muscle cell migration (GO:0014910)3.09412220
57regulation of extracellular matrix disassembly (GO:0010715)3.08065836
58positive regulation of actin filament depolymerization (GO:0030836)3.06557045
59regulation of collagen metabolic process (GO:0010712)3.06164768
60collagen catabolic process (GO:0030574)3.05121011
61vascular endothelial growth factor signaling pathway (GO:0038084)3.04039694
62hypotonic response (GO:0006971)3.03140532
63positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.02653245
64multicellular organismal macromolecule metabolic process (GO:0044259)3.00914636
65SMAD protein complex assembly (GO:0007183)2.99543881
66heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.96796041
67cortical actin cytoskeleton organization (GO:0030866)2.96534535
68mesenchymal-epithelial cell signaling (GO:0060638)2.94203304
69positive regulation of osteoblast proliferation (GO:0033690)2.92996470
70positive regulation of axon extension (GO:0045773)2.92296656
71negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.92236725
72positive regulation of endothelial cell apoptotic process (GO:2000353)2.91594834
73wound healing, spreading of cells (GO:0044319)2.89984013
74positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.88989938
75glomerular epithelial cell development (GO:0072310)2.88216420
76retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87368459
77bone trabecula formation (GO:0060346)2.86585542
78extracellular matrix disassembly (GO:0022617)2.85726446
79lipopolysaccharide biosynthetic process (GO:0009103)2.84960810
80mesenchymal cell differentiation involved in kidney development (GO:0072161)2.84690722
81mesenchymal cell differentiation involved in renal system development (GO:2001012)2.84690722
82regulation of type B pancreatic cell apoptotic process (GO:2000674)2.84190388
83cell-substrate junction assembly (GO:0007044)2.83339532
84basement membrane organization (GO:0071711)2.81342775
85endothelial cell chemotaxis (GO:0035767)2.80724740
86multicellular organismal metabolic process (GO:0044236)2.80237790
87negative regulation of axon extension involved in axon guidance (GO:0048843)2.79934441
88cell migration involved in heart development (GO:0060973)2.76601300
89substrate adhesion-dependent cell spreading (GO:0034446)2.75887954
90stress fiber assembly (GO:0043149)2.75564297
91multicellular organismal catabolic process (GO:0044243)2.74386273
92establishment of viral latency (GO:0019043)2.73505366
93cortical cytoskeleton organization (GO:0030865)2.73309853
94regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.71436029
95extracellular matrix organization (GO:0030198)2.71310337
96negative regulation of stem cell proliferation (GO:2000647)2.70384694
97extracellular structure organization (GO:0043062)2.70207388
98positive regulation of collagen biosynthetic process (GO:0032967)2.67569327
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.63540716
100negative regulation of anoikis (GO:2000811)2.63361471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse5.54193424
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.40924888
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.44727035
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.09057581
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.31722784
6* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.23500611
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.15434281
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.96125155
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.95612493
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.92258407
11BRD4_25478319_ChIP-Seq_HGPS_Human2.90387987
12ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.86082197
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.69494192
14* CJUN_26792858_Chip-Seq_BT549_Human2.52700084
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.47464320
16CLOCK_20551151_ChIP-Seq_293T_Human2.44996205
17JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.43297014
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.32672734
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.32672734
20JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.27963422
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.03994992
22CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.03182094
23DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.96353657
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96135273
25KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92998474
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88222904
27ATF3_27146783_Chip-Seq_COLON_Human1.87295211
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83704448
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.80247662
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.79960818
31UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.78744471
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.78386788
33TP53_22127205_ChIP-Seq_IMR90_Human1.73025047
34UBF1/2_26484160_Chip-Seq_HMECs_Human1.72436615
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.69686742
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62365484
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59654423
38SMC1_22415368_ChIP-Seq_MEFs_Mouse1.55503300
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.52312039
40RACK7_27058665_Chip-Seq_MCF-7_Human1.51304963
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46958118
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46681113
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.46112915
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.45812183
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.44308061
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43421963
47EP300_21415370_ChIP-Seq_HL-1_Mouse1.42418470
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39997119
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39547856
50TP53_23651856_ChIP-Seq_MEFs_Mouse1.38346513
51SMC3_22415368_ChIP-Seq_MEFs_Mouse1.33695981
52ZNF263_19887448_ChIP-Seq_K562_Human1.33312905
53CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33192300
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32248267
55NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31954924
56LXR_22292898_ChIP-Seq_THP-1_Human1.29201666
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26125141
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23526488
59SA1_22415368_ChIP-Seq_MEFs_Mouse1.22577695
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22338055
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22064267
62TP53_18474530_ChIP-ChIP_U2OS_Human1.21578284
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20568726
64SOX2_20726797_ChIP-Seq_SW620_Human1.14414509
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.10518803
66ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10059652
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08246864
68TBX20_22328084_ChIP-Seq_HEART_Mouse1.08220961
69TBX20_22080862_ChIP-Seq_HEART_Mouse1.08220961
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08024715
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.07827534
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.06688674
73* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.05769353
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03197920
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02071422
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01623066
77FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99866844
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98635483
79ESR1_21235772_ChIP-Seq_MCF-7_Human0.97581773
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97257997
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97257997
82EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94971307
83NFI_21473784_ChIP-Seq_ESCs_Mouse0.94632751
84NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94161064
85SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91441960
86TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90759648
87TP53_16413492_ChIP-PET_HCT116_Human0.90207590
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86922193
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86010205
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85549879
91TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85541712
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.85535552
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84121095
94PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.83877170
95EOMES_21245162_ChIP-Seq_HESCs_Human0.82406762
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82202088
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.79301941
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79297826
99KLF4_18555785_ChIP-Seq_MESCs_Mouse0.78978161
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77734036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.73795315
2MP0005257_abnormal_intraocular_pressure4.23819989
3MP0003705_abnormal_hypodermis_morpholog4.12751882
4MP0004272_abnormal_basement_membrane4.04488401
5MP0003279_aneurysm4.02048287
6MP0001958_emphysema3.44021308
7MP0005275_abnormal_skin_tensile3.38705287
8MP0005503_abnormal_tendon_morphology3.17259735
9MP0003950_abnormal_plasma_membrane2.99464676
10MP0003566_abnormal_cell_adhesion2.99111088
11MP0001542_abnormal_bone_strength2.73521019
12MP0010368_abnormal_lymphatic_system2.72193537
13MP0000751_myopathy2.71018633
14MP0006054_spinal_hemorrhage2.51483091
15MP0010030_abnormal_orbit_morphology2.20862700
16MP0002060_abnormal_skin_morphology2.20825527
17MP0005623_abnormal_meninges_morphology2.19315344
18MP0004510_myositis2.17232846
19MP0009780_abnormal_chondrocyte_physiolo2.14031267
20MP0009384_cardiac_valve_regurgitation2.11702086
21MP0005023_abnormal_wound_healing2.04969546
22MP0000013_abnormal_adipose_tissue1.96157525
23MP0000767_abnormal_smooth_muscle1.93901055
24MP0003091_abnormal_cell_migration1.91698730
25MP0002877_abnormal_melanocyte_morpholog1.85924750
26MP0003191_abnormal_cellular_cholesterol1.81093078
27MP0001299_abnormal_eye_distance/1.75978931
28MP0005508_abnormal_skeleton_morphology1.64819688
29MP0000749_muscle_degeneration1.63263433
30MP0002295_abnormal_pulmonary_circulatio1.59914914
31MP0001243_abnormal_dermal_layer1.59138567
32MP0002896_abnormal_bone_mineralization1.54472988
33MP0000534_abnormal_ureter_morphology1.48035589
34MP0009840_abnormal_foam_cell1.43545061
35MP0005165_increased_susceptibility_to1.36056900
36MP0000750_abnormal_muscle_regeneration1.31949485
37MP0000003_abnormal_adipose_tissue1.30545488
38MP0002332_abnormal_exercise_endurance1.26425030
39MP0000733_abnormal_muscle_development1.21486933
40MP0010352_gastrointestinal_tract_polyps1.20662438
41MP0009250_abnormal_appendicular_skeleto1.17274427
42MP0005595_abnormal_vascular_smooth1.16383661
43MP0004134_abnormal_chest_morphology1.13579902
44MP0003941_abnormal_skin_development1.12407503
45MP0001879_abnormal_lymphatic_vessel1.10888572
46MP0005164_abnormal_response_to1.10191751
47MP0002254_reproductive_system_inflammat1.08319262
48MP0004858_abnormal_nervous_system1.07773887
49MP0009053_abnormal_anal_canal1.06641119
50MP0005390_skeleton_phenotype1.05527571
51MP0000762_abnormal_tongue_morphology1.05214114
52MP0005197_abnormal_uvea_morphology1.04359354
53MP0003942_abnormal_urinary_system1.03140531
54MP0010386_abnormal_urinary_bladder1.01474774
55MP0000343_altered_response_to1.01415158
56MP0000759_abnormal_skeletal_muscle1.00170731
57MP0002933_joint_inflammation0.96011223
58MP0003123_paternal_imprinting0.95141472
59MP0000163_abnormal_cartilage_morphology0.92304137
60MP0003385_abnormal_body_wall0.90159317
61MP0005058_abnormal_lysosome_morphology0.90059882
62MP0002177_abnormal_outer_ear0.89571182
63MP0002108_abnormal_muscle_morphology0.88075018
64MP0001849_ear_inflammation0.86955575
65MP0002932_abnormal_joint_morphology0.85432543
66MP0002282_abnormal_trachea_morphology0.85099733
67MP0003075_altered_response_to0.84347792
68MP0002168_other_aberrant_phenotype0.83526623
69MP0005330_cardiomyopathy0.79960399
70MP0002113_abnormal_skeleton_development0.79687010
71MP0000858_altered_metastatic_potential0.79132485
72MP0001614_abnormal_blood_vessel0.77747936
73MP0002998_abnormal_bone_remodeling0.76565340
74MP0001915_intracranial_hemorrhage0.75808514
75MP0003283_abnormal_digestive_organ0.73235376
76MP0003795_abnormal_bone_structure0.67131117
77MP0002128_abnormal_blood_circulation0.65654048
78MP0000428_abnormal_craniofacial_morphol0.64297156
79MP0003448_altered_tumor_morphology0.62902412
80MP0008775_abnormal_heart_ventricle0.62877570
81MP0001533_abnormal_skeleton_physiology0.62535267
82MP0002115_abnormal_skeleton_extremities0.62280128
83MP0001175_abnormal_lung_morphology0.61652823
84MP0005193_abnormal_anterior_eye0.59164200
85MP0002925_abnormal_cardiovascular_devel0.57902532
86MP0010771_integument_phenotype0.57298146
87MP0000432_abnormal_head_morphology0.54820269
88MP0003045_fibrosis0.54660318
89MP0004087_abnormal_muscle_fiber0.54496285
90MP0003115_abnormal_respiratory_system0.53824248
91MP0004233_abnormal_muscle_weight0.53803645
92MP0003453_abnormal_keratinocyte_physiol0.53587478
93MP0005369_muscle_phenotype0.53197248
94MP0005621_abnormal_cell_physiology0.52074625
95MP0002972_abnormal_cardiac_muscle0.50842641
96MP0003329_amyloid_beta_deposits0.50601020
97MP0003828_pulmonary_edema0.49985228
98MP0000249_abnormal_blood_vessel0.48568825
99MP0002106_abnormal_muscle_physiology0.46679606
100MP0003755_abnormal_palate_morphology0.45444695

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)9.11810861
2Protrusio acetabuli (HP:0003179)6.93180015
3Ankle contracture (HP:0006466)5.12644349
4Follicular hyperkeratosis (HP:0007502)4.96107395
5Atrophic scars (HP:0001075)4.66975579
6Aortic dissection (HP:0002647)4.59864141
7Spinal rigidity (HP:0003306)4.31820707
8Type 1 muscle fiber predominance (HP:0003803)4.18806351
9Bladder diverticulum (HP:0000015)4.02653244
10Slender build (HP:0001533)3.97003390
11Soft skin (HP:0000977)3.86764651
12Abnormality of dentin (HP:0010299)3.83919155
13Vertebral compression fractures (HP:0002953)3.79744298
14Fragile skin (HP:0001030)3.68880691
15Aortic aneurysm (HP:0004942)3.58631526
16Wormian bones (HP:0002645)3.55811991
17Vascular tortuosity (HP:0004948)3.53958126
18Mildly elevated creatine phosphokinase (HP:0008180)3.34442226
19Arterial tortuosity (HP:0005116)3.30585336
20Genu recurvatum (HP:0002816)3.28928242
21Cervical subluxation (HP:0003308)3.21137704
22Blue sclerae (HP:0000592)3.19272403
23Shallow orbits (HP:0000586)3.16884437
24Peritonitis (HP:0002586)3.13899486
25Cardiovascular calcification (HP:0011915)3.11885320
26Neonatal short-limb short stature (HP:0008921)3.11452813
27Osteolytic defects of the hand bones (HP:0009699)3.09057336
28Osteolytic defects of the phalanges of the hand (HP:0009771)3.09057336
29Short nail (HP:0001799)2.98716360
30Broad metatarsal (HP:0001783)2.97137432
31Increased connective tissue (HP:0009025)2.95635043
32Dilatation of the ascending aorta (HP:0005111)2.86508395
33Elbow flexion contracture (HP:0002987)2.86360574
34Distal upper limb amyotrophy (HP:0007149)2.85283936
35Upper limb amyotrophy (HP:0009129)2.85283936
36Biconcave vertebral bodies (HP:0004586)2.84142309
37Generalized amyotrophy (HP:0003700)2.80836646
38Increased variability in muscle fiber diameter (HP:0003557)2.80155055
39Spondylolisthesis (HP:0003302)2.78562378
40Bowel diverticulosis (HP:0005222)2.77395210
41Reduced subcutaneous adipose tissue (HP:0003758)2.74853015
42Joint stiffness (HP:0001387)2.74811819
43Achilles tendon contracture (HP:0001771)2.70781691
44Mitral regurgitation (HP:0001653)2.65304127
45Joint laxity (HP:0001388)2.64886349
46Abnormal delivery (HP:0001787)2.57090318
47Hypoventilation (HP:0002791)2.55950594
48Hand muscle atrophy (HP:0009130)2.52796430
49Glucose intolerance (HP:0000833)2.51487285
50Limb-girdle muscle weakness (HP:0003325)2.50554517
51Aortic regurgitation (HP:0001659)2.50302980
52Distal lower limb amyotrophy (HP:0008944)2.49835094
53Hyperextensible skin (HP:0000974)2.46450591
54Abnormality of skeletal muscle fiber size (HP:0012084)2.45809722
55Vascular calcification (HP:0004934)2.45713804
56Distal lower limb muscle weakness (HP:0009053)2.40059164
57Abnormality of the Achilles tendon (HP:0005109)2.38391669
58Natal tooth (HP:0000695)2.37195188
59Mitral valve prolapse (HP:0001634)2.36276835
60Cerebral aneurysm (HP:0004944)2.21459254
61Difficulty climbing stairs (HP:0003551)2.18885134
62Bradycardia (HP:0001662)2.18614317
63Ectopia lentis (HP:0001083)2.17051392
64Delayed gross motor development (HP:0002194)2.16254036
65Protruding ear (HP:0000411)2.15172172
66Aortic valve stenosis (HP:0001650)2.14482677
67Long toe (HP:0010511)2.05191530
68Abnormality of the acetabulum (HP:0003170)2.04701408
69Overgrowth (HP:0001548)2.04502917
70Entropion (HP:0000621)2.03033062
71Mitral stenosis (HP:0001718)2.01955282
72Abnormality of the distal phalanges of the toes (HP:0010182)2.01132802
73Limb-girdle muscle atrophy (HP:0003797)2.00312647
74Wrist flexion contracture (HP:0001239)1.99301007
75Ulnar bowing (HP:0003031)1.97676742
76Thin skin (HP:0000963)1.96040294
77Short clavicles (HP:0000894)1.95446721
78Lower limb amyotrophy (HP:0007210)1.94983742
79Hyperacusis (HP:0010780)1.92971383
80Insulin resistance (HP:0000855)1.91184864
81Osteopenia (HP:0000938)1.87484803
82Infantile muscular hypotonia (HP:0008947)1.85871038
83Renal duplication (HP:0000075)1.84990814
84Insomnia (HP:0100785)1.84634287
85Myocardial infarction (HP:0001658)1.84389569
86Camptodactyly of toe (HP:0001836)1.84185414
87Round ear (HP:0100830)1.83446202
88Mild short stature (HP:0003502)1.83344326
89Disproportionate tall stature (HP:0001519)1.83230648
90Congenital glaucoma (HP:0001087)1.83179246
91Coxa vara (HP:0002812)1.82648621
92Breech presentation (HP:0001623)1.79503085
93Upper limb muscle weakness (HP:0003484)1.77943278
94Nuclear cataract (HP:0100018)1.77071678
95Abnormality of skull ossification (HP:0002703)1.76633779
96Abnormality of the umbilical cord (HP:0010881)1.76194283
97Aneurysm (HP:0002617)1.74798637
98Flat cornea (HP:0007720)1.73864874
99Delayed cranial suture closure (HP:0000270)1.73642617
100Hallux valgus (HP:0001822)1.71951764

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.69034298
2LIMK14.24991377
3EPHA23.37825913
4MYLK3.07268315
5NME23.05822353
6PTK22.86621626
7LMTK22.66021326
8ERN12.53407660
9TESK22.51896837
10PDGFRA2.50590813
11TTN2.42439453
12PAK42.38927703
13EPHB22.33736237
14ARAF2.31122686
15MST1R2.27943383
16MOS2.24126579
17VRK22.13451429
18TGFBR22.10913423
19IRAK32.09843818
20PIM21.87654657
21ERBB41.86051004
22TAOK21.73855860
23MET1.67766268
24ABL21.58324100
25MAP3K31.44966594
26STK381.44432274
27DDR21.43350864
28PRKD21.37406856
29NTRK11.36426144
30SIK11.36327909
31LATS21.35616377
32PAK21.33359847
33NEK91.30436831
34PTK2B1.25563654
35ICK1.17576472
36ILK1.11762472
37EPHB11.06019021
38STK101.02648370
39CDK81.01143184
40RIPK10.99865562
41FLT30.99855812
42BUB10.99789229
43ROCK20.98266484
44HIPK20.94887452
45BMX0.92769398
46MAP3K60.92012349
47MAP3K120.89535081
48ROCK10.88698498
49ADRBK10.88331790
50TRPM70.87832755
51DAPK30.87791573
52LATS10.83815076
53PAK10.80467371
54PRPF4B0.78286885
55GRK70.76549823
56PHKG10.75285998
57PHKG20.75285998
58CDC42BPA0.72790163
59DAPK10.72070255
60MAPKAPK30.71552215
61DMPK0.68847801
62BRAF0.68179906
63MAP2K70.68176975
64SCYL20.66840778
65MAP2K30.64951885
66PRKG20.62054163
67GSK3A0.60540101
68MTOR0.53730519
69PDGFRB0.53649543
70STK160.50059739
71TRIB30.49520699
72SMG10.49127088
73MAP3K80.48103052
74PAK60.47765710
75PTK60.47738915
76MAPKAPK20.42529432
77TBK10.41677374
78MELK0.41604931
79CDK140.41173509
80STK38L0.39711071
81GRK50.39289780
82AURKA0.38738869
83CDK150.36525214
84CDK180.35806758
85CAMK2G0.33947194
86RPS6KA20.33389758
87MAP3K110.33319461
88STK30.32739375
89CDK11A0.32574948
90STK40.32357907
91PRKD10.29981060
92NEK10.29258379
93PKN20.29204401
94WNK10.28736555
95PIK3CG0.28710446
96KDR0.26531059
97BRSK10.25859414
98PRKCE0.24713538
99CSNK1G30.24373005
100CSNK1A1L0.23055917

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.08377063
2ECM-receptor interaction_Homo sapiens_hsa045123.87665560
3Focal adhesion_Homo sapiens_hsa045103.09952148
4Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.60469290
5Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.39068630
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.35562426
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.14197047
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07850044
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.07471570
10Proteoglycans in cancer_Homo sapiens_hsa052052.07274796
11Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01923501
12Galactose metabolism_Homo sapiens_hsa000521.92773095
13Vibrio cholerae infection_Homo sapiens_hsa051101.86000072
14Protein digestion and absorption_Homo sapiens_hsa049741.85929077
15Dilated cardiomyopathy_Homo sapiens_hsa054141.78537175
16Regulation of actin cytoskeleton_Homo sapiens_hsa048101.76651804
17Amoebiasis_Homo sapiens_hsa051461.71346472
18Bladder cancer_Homo sapiens_hsa052191.69661445
19N-Glycan biosynthesis_Homo sapiens_hsa005101.64614050
20Proteasome_Homo sapiens_hsa030501.60145824
21Other glycan degradation_Homo sapiens_hsa005111.49974324
22Small cell lung cancer_Homo sapiens_hsa052221.47715671
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43990747
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42011154
25Shigellosis_Homo sapiens_hsa051311.41186179
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40298236
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37127193
28Folate biosynthesis_Homo sapiens_hsa007901.35702546
29PI3K-Akt signaling pathway_Homo sapiens_hsa041511.33512840
30Hippo signaling pathway_Homo sapiens_hsa043901.31297272
31Pentose phosphate pathway_Homo sapiens_hsa000301.28333918
32Adherens junction_Homo sapiens_hsa045201.28048328
33TGF-beta signaling pathway_Homo sapiens_hsa043501.27773461
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.21363835
35Sulfur relay system_Homo sapiens_hsa041221.20459840
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13601937
37Basal cell carcinoma_Homo sapiens_hsa052171.12610906
38Fructose and mannose metabolism_Homo sapiens_hsa000511.10712154
39Salivary secretion_Homo sapiens_hsa049701.05307459
40Melanoma_Homo sapiens_hsa052181.04259108
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02083472
42Lysosome_Homo sapiens_hsa041421.01239129
43Salmonella infection_Homo sapiens_hsa051320.96150261
44Endocytosis_Homo sapiens_hsa041440.95312362
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94515990
46Pathways in cancer_Homo sapiens_hsa052000.91485043
47Fatty acid elongation_Homo sapiens_hsa000620.90579389
48p53 signaling pathway_Homo sapiens_hsa041150.89388670
49Glutathione metabolism_Homo sapiens_hsa004800.88754505
50TNF signaling pathway_Homo sapiens_hsa046680.87298101
51Hedgehog signaling pathway_Homo sapiens_hsa043400.86697506
52MicroRNAs in cancer_Homo sapiens_hsa052060.81982286
53Malaria_Homo sapiens_hsa051440.80564960
54Prion diseases_Homo sapiens_hsa050200.80172067
55Pyrimidine metabolism_Homo sapiens_hsa002400.79852797
56Axon guidance_Homo sapiens_hsa043600.79657475
57Chronic myeloid leukemia_Homo sapiens_hsa052200.78352575
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76499674
59Thyroid cancer_Homo sapiens_hsa052160.76360622
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.74494553
61Pancreatic cancer_Homo sapiens_hsa052120.73469002
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63848368
63Biosynthesis of amino acids_Homo sapiens_hsa012300.62028308
64Gap junction_Homo sapiens_hsa045400.60990460
65Prostate cancer_Homo sapiens_hsa052150.58614703
66Sulfur metabolism_Homo sapiens_hsa009200.58014395
67Melanogenesis_Homo sapiens_hsa049160.56467869
68Apoptosis_Homo sapiens_hsa042100.56325036
69Pertussis_Homo sapiens_hsa051330.55926578
70Tight junction_Homo sapiens_hsa045300.55206702
71Wnt signaling pathway_Homo sapiens_hsa043100.55045251
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52601399
73Protein export_Homo sapiens_hsa030600.52061655
74Insulin secretion_Homo sapiens_hsa049110.49572122
75Rap1 signaling pathway_Homo sapiens_hsa040150.49499941
76Complement and coagulation cascades_Homo sapiens_hsa046100.49079268
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47486173
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46604793
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43345950
80Phagosome_Homo sapiens_hsa041450.42808130
81Hepatitis B_Homo sapiens_hsa051610.41773192
82Thyroid hormone synthesis_Homo sapiens_hsa049180.41116564
83Cocaine addiction_Homo sapiens_hsa050300.40370802
84Nucleotide excision repair_Homo sapiens_hsa034200.40174773
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39439198
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37687029
87Endometrial cancer_Homo sapiens_hsa052130.36628461
88Sphingolipid metabolism_Homo sapiens_hsa006000.35364434
89Notch signaling pathway_Homo sapiens_hsa043300.34913483
90HTLV-I infection_Homo sapiens_hsa051660.34862965
91Glioma_Homo sapiens_hsa052140.34584732
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32827546
93Ras signaling pathway_Homo sapiens_hsa040140.32139484
94RNA polymerase_Homo sapiens_hsa030200.32029641
95Renal cell carcinoma_Homo sapiens_hsa052110.31832942
96Circadian rhythm_Homo sapiens_hsa047100.31601136
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30217626
98Synaptic vesicle cycle_Homo sapiens_hsa047210.29602139
99GnRH signaling pathway_Homo sapiens_hsa049120.28708671
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.28456327

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