APBB1IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.37818381
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.37818381
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.37818381
4modulation by symbiont of host immune response (GO:0052553)5.37818381
5positive regulation by symbiont of host defense response (GO:0052509)5.37818381
6modulation by symbiont of host defense response (GO:0052031)5.37818381
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.34002473
8positive regulation of gamma-delta T cell activation (GO:0046645)5.16204845
9regulation of B cell receptor signaling pathway (GO:0050855)4.65280027
10neutrophil activation involved in immune response (GO:0002283)4.59997810
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59189574
12negative regulation of cell killing (GO:0031342)4.59189574
13detection of other organism (GO:0098543)4.54545243
14detection of bacterium (GO:0016045)4.39131912
15leukocyte aggregation (GO:0070486)4.38735985
16regulation of interferon-beta biosynthetic process (GO:0045357)4.36775278
17response to peptidoglycan (GO:0032494)4.16376597
18immunoglobulin mediated immune response (GO:0016064)4.16356254
19negative regulation of lymphocyte mediated immunity (GO:0002707)4.05956722
20macrophage activation involved in immune response (GO:0002281)4.04359195
21cellular response to interleukin-15 (GO:0071350)4.03113642
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.97493863
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.97493863
24detection of external biotic stimulus (GO:0098581)3.97408679
25respiratory burst (GO:0045730)3.95791244
26positive regulation of interferon-alpha production (GO:0032727)3.87449561
27detection of molecule of bacterial origin (GO:0032490)3.86549755
28negative regulation of T cell mediated immunity (GO:0002710)3.82128277
29neutrophil activation (GO:0042119)3.81759280
30cellular extravasation (GO:0045123)3.79285575
31antigen processing and presentation of endogenous antigen (GO:0019883)3.76751470
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.72715843
33regulation of interferon-alpha production (GO:0032647)3.71024529
34granulocyte activation (GO:0036230)3.70663482
35positive regulation of B cell differentiation (GO:0045579)3.65688733
36negative regulation of interleukin-12 production (GO:0032695)3.62695761
37negative regulation of leukocyte mediated immunity (GO:0002704)3.62165319
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59138396
39response to host immune response (GO:0052572)3.59138396
40regulation of B cell differentiation (GO:0045577)3.58202516
41response to muramyl dipeptide (GO:0032495)3.57532361
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.57027577
43regulation of gamma-delta T cell differentiation (GO:0045586)3.54804287
44regulation of gamma-delta T cell activation (GO:0046643)3.54487584
45positive T cell selection (GO:0043368)3.48302716
46regulation of interleukin-12 biosynthetic process (GO:0045075)3.47969479
47detection of biotic stimulus (GO:0009595)3.47418121
48myeloid cell activation involved in immune response (GO:0002275)3.45617052
49B cell receptor signaling pathway (GO:0050853)3.39463075
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.38316772
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.37963658
52T cell migration (GO:0072678)3.37877443
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37202800
54response to host (GO:0075136)3.37202800
55response to host defenses (GO:0052200)3.37202800
56T cell selection (GO:0045058)3.36822241
57negative regulation of phagocytosis (GO:0050765)3.28557997
58tolerance induction (GO:0002507)3.24521344
59regulation of T cell tolerance induction (GO:0002664)3.23838034
60interferon-gamma production (GO:0032609)3.23031334
61microglial cell activation (GO:0001774)3.22831318
62regulation of myeloid leukocyte mediated immunity (GO:0002886)3.22696116
63antigen processing and presentation via MHC class Ib (GO:0002475)3.20909001
64B cell mediated immunity (GO:0019724)3.20177641
65myeloid dendritic cell activation (GO:0001773)3.19726269
66leukocyte cell-cell adhesion (GO:0007159)3.19554866
67positive regulation of antigen processing and presentation (GO:0002579)3.19534840
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18848607
69thymic T cell selection (GO:0045061)3.17728610
70positive thymic T cell selection (GO:0045059)3.16441999
71positive regulation of mast cell activation (GO:0033005)3.16321158
72regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.14142265
73germinal center formation (GO:0002467)3.13865435
74lipopolysaccharide-mediated signaling pathway (GO:0031663)3.13630924
75regulation of tolerance induction (GO:0002643)3.13251346
76activated T cell proliferation (GO:0050798)3.13025298
77negative regulation of erythrocyte differentiation (GO:0045647)3.12052202
78leukocyte degranulation (GO:0043299)3.11025019
79mast cell activation (GO:0045576)3.09215535
80defense response to protozoan (GO:0042832)3.08643519
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08378392
82leukocyte migration involved in inflammatory response (GO:0002523)3.08009916
83interferon-gamma-mediated signaling pathway (GO:0060333)3.07148863
84regulation of mast cell degranulation (GO:0043304)3.05558231
85Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03341027
86regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.03203320
87negative thymic T cell selection (GO:0045060)3.02333736
88positive regulation of granulocyte differentiation (GO:0030854)3.01864178
89regulation of T cell mediated cytotoxicity (GO:0001914)3.01861883
90negative T cell selection (GO:0043383)3.01314444
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.00619793
92response to type I interferon (GO:0034340)2.99971462
93regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99000183
94neutrophil mediated immunity (GO:0002446)2.98315596
95regulation of leukocyte degranulation (GO:0043300)2.98235074
96regulation of mast cell activation (GO:0033003)2.97840900
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.97326552
98negative regulation of T-helper cell differentiation (GO:0045623)2.97326552
99type I interferon signaling pathway (GO:0060337)2.97085348
100cellular response to type I interferon (GO:0071357)2.97085348
101myeloid dendritic cell differentiation (GO:0043011)2.97026273
102regulation of natural killer cell mediated immunity (GO:0002715)2.96219032
103regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.96219032
104response to protozoan (GO:0001562)2.95475191
105antigen receptor-mediated signaling pathway (GO:0050851)2.93482621
106positive regulation of interferon-beta production (GO:0032728)2.91481914
107myeloid leukocyte activation (GO:0002274)2.90312485
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.89930360
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.89025134
110mature B cell differentiation (GO:0002335)2.88750945
111macrophage activation (GO:0042116)2.86411492
112cellular response to zinc ion (GO:0071294)2.84052150
113regulation of mast cell activation involved in immune response (GO:0033006)2.83401473
114negative regulation of granulocyte differentiation (GO:0030853)2.83148567
115positive regulation of mast cell degranulation (GO:0043306)2.82981272
116positive regulation of mast cell activation involved in immune response (GO:0033008)2.82981272
117positive regulation of isotype switching (GO:0045830)2.81740693
118regulation of antigen processing and presentation (GO:0002577)2.79930444
119NIK/NF-kappaB signaling (GO:0038061)2.73522796
120regulation of alpha-beta T cell proliferation (GO:0046640)2.73229838
121cellular defense response (GO:0006968)2.71882494
122production of molecular mediator involved in inflammatory response (GO:0002532)2.71040220
123positive regulation of cytokine biosynthetic process (GO:0042108)2.69278894
124pinocytosis (GO:0006907)2.69117408
125B cell homeostasis (GO:0001782)2.67904431
126positive regulation of immunoglobulin mediated immune response (GO:0002891)2.67604897
127positive regulation of B cell mediated immunity (GO:0002714)2.67604897
128neutrophil chemotaxis (GO:0030593)2.66591975
129response to fungus (GO:0009620)2.66502716
130positive regulation of macrophage differentiation (GO:0045651)2.66309193
131positive regulation of chemokine biosynthetic process (GO:0045080)2.66132495
132response to interleukin-15 (GO:0070672)2.63950466
133cellular response to interferon-beta (GO:0035458)2.62409219
134negative regulation of interleukin-6 production (GO:0032715)2.60354089

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.31605717
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.20956608
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.68732663
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54978229
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.17068710
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.78900246
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.76093873
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.67429100
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.62156825
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.45875595
11E2F7_22180533_ChIP-Seq_HELA_Human3.34575000
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30487148
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.20777507
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.98675020
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.98590757
16* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96951473
17SCL_19346495_ChIP-Seq_HPC-7_Human2.81052473
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61957658
19* SPI1_23547873_ChIP-Seq_NB4_Human2.53414507
20VDR_21846776_ChIP-Seq_THP-1_Human2.51555508
21* MYB_26560356_Chip-Seq_TH2_Human2.45137896
22MYC_22102868_ChIP-Seq_BL_Human2.44775995
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42501987
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.38341363
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.37514613
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.36319713
27* RUNX_20019798_ChIP-Seq_JUKART_Human2.35992810
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32671740
29MAF_26560356_Chip-Seq_TH1_Human2.26808603
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24110268
31VDR_24763502_ChIP-Seq_THP-1_Human2.22833517
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19477984
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14271645
34* MYB_26560356_Chip-Seq_TH1_Human2.12104995
35RUNX1_22412390_ChIP-Seq_EML_Mouse2.11135490
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.04031169
37SPI1_23127762_ChIP-Seq_K562_Human2.00170271
38UTX_26944678_Chip-Seq_JUKART_Human1.93612387
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79961772
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77687173
41TCF7_22412390_ChIP-Seq_EML_Mouse1.75924958
42PU_27001747_Chip-Seq_BMDM_Mouse1.74005774
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65923848
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65616797
45* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59781171
46* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51925436
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.51742392
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51538289
49* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47329711
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43670750
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41329484
52* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38376950
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37189958
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36094123
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.35888649
56* MAF_26560356_Chip-Seq_TH2_Human1.35655891
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30952085
58FOXM1_23109430_ChIP-Seq_U2OS_Human1.28876788
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27768571
60* VDR_24787735_ChIP-Seq_THP-1_Human1.25769192
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25062877
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20748202
63* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20252815
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18435905
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18106801
66GATA3_26560356_Chip-Seq_TH2_Human1.17969693
67* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17569683
68KDM2B_26808549_Chip-Seq_DND41_Human1.16946793
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.16823990
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13997600
71* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12417503
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.11309638
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11307868
74VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09035219
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08694900
76KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08606884
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07473185
78STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07012040
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06614088
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05209276
81BCL6_27268052_Chip-Seq_Bcells_Human1.04638315
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.01825239
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99278775
84* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98608214
85ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98533465
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98329576
87TFEB_21752829_ChIP-Seq_HELA_Human0.96949183
88LXR_22292898_ChIP-Seq_THP-1_Human0.96670518
89* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95778468
90GATA1_22025678_ChIP-Seq_K562_Human0.95717810
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92605655
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.91710541
93BCOR_27268052_Chip-Seq_Bcells_Human0.88318584
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85211965
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84614071
96* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83609355
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.83353678
98BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80477170
99NCOR1_26117541_ChIP-Seq_K562_Human0.80245759
100* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80172660
101GATA2_19941826_ChIP-Seq_K562_Human0.79511175
102GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79307535
103SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77290305
104* E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75104613
105CIITA_25753668_ChIP-Seq_RAJI_Human0.72569480
106SPI1_20517297_ChIP-Seq_HL60_Human0.72142737
107GATA1_19941826_ChIP-Seq_K562_Human0.70907174
108* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70484705
109TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.70303913
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69546185
111ETS1_22383799_ChIP-Seq_G1ME_Mouse0.68315873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.05543399
2MP0003436_decreased_susceptibility_to3.53770893
3MP0003303_peritoneal_inflammation3.29192340
4MP0005671_abnormal_response_to3.09605250
5MP0005000_abnormal_immune_tolerance3.05907064
6MP0009785_altered_susceptibility_to3.01992907
7MP0002419_abnormal_innate_immunity2.98368887
8MP0001800_abnormal_humoral_immune2.92214129
9MP0005387_immune_system_phenotype2.90331867
10MP0001790_abnormal_immune_system2.90331867
11MP0000685_abnormal_immune_system2.89015768
12MP0002452_abnormal_antigen_presenting2.81432786
13MP0006082_CNS_inflammation2.78700591
14MP0002148_abnormal_hypersensitivity_rea2.78617749
15MP0005025_abnormal_response_to2.77364013
16MP0002723_abnormal_immune_serum2.67112989
17MP0002420_abnormal_adaptive_immunity2.55769248
18MP0001819_abnormal_immune_cell2.55449130
19MP0005464_abnormal_platelet_physiology2.46766549
20MP0003724_increased_susceptibility_to2.35358375
21MP0002405_respiratory_system_inflammati2.22636015
22MP0002398_abnormal_bone_marrow2.18752184
23MP0005058_abnormal_lysosome_morphology2.15020186
24MP0002396_abnormal_hematopoietic_system2.12465160
25MP0000716_abnormal_immune_system2.05873241
26MP0003763_abnormal_thymus_physiology2.05046723
27MP0003300_gastrointestinal_ulcer2.04417691
28MP0009278_abnormal_bone_marrow2.04213020
29MP0009333_abnormal_splenocyte_physiolog2.02703531
30MP0001853_heart_inflammation1.97958846
31MP0002166_altered_tumor_susceptibility1.97508591
32MP0004510_myositis1.95122128
33MP0004947_skin_inflammation1.89309545
34MP0001533_abnormal_skeleton_physiology1.88163089
35MP0002006_tumorigenesis1.87954749
36MP0000569_abnormal_digit_pigmentation1.87179148
37MP0000689_abnormal_spleen_morphology1.86642013
38MP0001845_abnormal_inflammatory_respons1.85814212
39MP0003172_abnormal_lysosome_physiology1.85713898
40MP0005397_hematopoietic_system_phenotyp1.78156661
41MP0001545_abnormal_hematopoietic_system1.78156661
42MP0010155_abnormal_intestine_physiology1.78044585
43MP0002722_abnormal_immune_system1.77358080
44MP0002429_abnormal_blood_cell1.71472210
45MP0004808_abnormal_hematopoietic_stem1.70468472
46MP0008260_abnormal_autophagy1.58895277
47MP0005174_abnormal_tail_pigmentation1.56971715
48MP0003448_altered_tumor_morphology1.55570339
49MP0000858_altered_metastatic_potential1.50113445
50MP0001873_stomach_inflammation1.47593405
51MP0008469_abnormal_protein_level1.44455739
52MP0000703_abnormal_thymus_morphology1.43804017
53MP0003191_abnormal_cellular_cholesterol1.43313829
54MP0004381_abnormal_hair_follicle1.41824176
55MP0005451_abnormal_body_composition1.41278153
56MP0002933_joint_inflammation1.41249367
57MP0000465_gastrointestinal_hemorrhage1.40957676
58MP0005310_abnormal_salivary_gland1.32195355
59MP0002998_abnormal_bone_remodeling1.31862473
60MP0000343_altered_response_to1.31278335
61MP0004883_abnormal_blood_vessel1.23109757
62MP0009764_decreased_sensitivity_to1.21862177
63MP0001851_eye_inflammation1.21274401
64MP0000490_abnormal_crypts_of1.20324927
65MP0003183_abnormal_peptide_metabolism1.19072369
66MP0003075_altered_response_to1.13178177
67MP0003866_abnormal_defecation1.11608488
68MP0005076_abnormal_cell_differentiation1.11049970
69MP0010352_gastrointestinal_tract_polyps1.08575150
70MP0010307_abnormal_tumor_latency1.04074183
71MP0000015_abnormal_ear_pigmentation1.00682290
72MP0005390_skeleton_phenotype0.92667490
73MP0005166_decreased_susceptibility_to0.92619469
74MP0003690_abnormal_glial_cell0.92601217
75MP0003828_pulmonary_edema0.92562577
76MP0002138_abnormal_hepatobiliary_system0.88656183
77MP0003566_abnormal_cell_adhesion0.85975847
78MP0000371_diluted_coat_color0.83676124
79MP0009763_increased_sensitivity_to0.82737598
80MP0005023_abnormal_wound_healing0.81510212
81MP0002019_abnormal_tumor_incidence0.80476812
82MP0003656_abnormal_erythrocyte_physiolo0.78439824
83MP0000249_abnormal_blood_vessel0.77885659
84MP0001986_abnormal_taste_sensitivity0.74999268
85MP0003279_aneurysm0.74595757
86MP0009840_abnormal_foam_cell0.73568548
87MP0003795_abnormal_bone_structure0.72787052
88MP0008057_abnormal_DNA_replication0.68819826
89MP0005075_abnormal_melanosome_morpholog0.67272345
90MP0003806_abnormal_nucleotide_metabolis0.66846395
91MP0003045_fibrosis0.64719816
92MP0003091_abnormal_cell_migration0.63433608
93MP0001663_abnormal_digestive_system0.63203492
94MP0000767_abnormal_smooth_muscle0.62603115
95MP0009765_abnormal_xenobiotic_induced0.62323130
96MP0002132_abnormal_respiratory_system0.62320119
97MP0004130_abnormal_muscle_cell0.62171945
98MP0002277_abnormal_respiratory_mucosa0.61706500
99MP0000604_amyloidosis0.61364767
100MP0006054_spinal_hemorrhage0.61127250
101MP0008004_abnormal_stomach_pH0.59846002
102MP0002095_abnormal_skin_pigmentation0.59627441
103MP0002009_preneoplasia0.58773047
104MP0003453_abnormal_keratinocyte_physiol0.57359746
105MP0008874_decreased_physiological_sensi0.57333316
106MP0008873_increased_physiological_sensi0.55192788
107MP0008007_abnormal_cellular_replicative0.55117095
108MP0005164_abnormal_response_to0.54769381
109MP0002136_abnormal_kidney_physiology0.54710320
110MP0005167_abnormal_blood-brain_barrier0.53991699
111MP0000609_abnormal_liver_physiology0.51250969
112MP0000313_abnormal_cell_death0.50806340
113MP0009115_abnormal_fat_cell0.50748053
114MP0001915_intracranial_hemorrhage0.50459194
115MP0001958_emphysema0.50133873
116MP0002877_abnormal_melanocyte_morpholog0.49689547
117MP0002693_abnormal_pancreas_physiology0.48598962
118MP0005319_abnormal_enzyme/_coenzyme0.46774724
119MP0003252_abnormal_bile_duct0.44983944
120MP0003221_abnormal_cardiomyocyte_apopto0.43805537

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.50164621
2Eczematoid dermatitis (HP:0000976)5.88668917
3Recurrent bacterial skin infections (HP:0005406)5.78683224
4Recurrent gram-negative bacterial infections (HP:0005420)4.54494195
5Elevated erythrocyte sedimentation rate (HP:0003565)4.30772961
6Myositis (HP:0100614)4.25809745
7Recurrent fungal infections (HP:0002841)4.23030711
8Mediastinal lymphadenopathy (HP:0100721)4.22019813
9Abnormality of macrophages (HP:0004311)3.98243712
10Recurrent viral infections (HP:0004429)3.95313291
11Recurrent skin infections (HP:0001581)3.88934728
12Obstructive lung disease (HP:0006536)3.87061959
13Chronic obstructive pulmonary disease (HP:0006510)3.87061959
14Systemic lupus erythematosus (HP:0002725)3.68990058
15Stomatitis (HP:0010280)3.60765756
16Autoimmune thrombocytopenia (HP:0001973)3.54452943
17Orchitis (HP:0100796)3.50123226
18Cellulitis (HP:0100658)3.40935915
19Meningitis (HP:0001287)3.38069651
20Optic neuritis (HP:0100653)3.35570751
21Retrobulbar optic neuritis (HP:0100654)3.35570751
22Gingivitis (HP:0000230)3.34674400
23IgM deficiency (HP:0002850)3.30526206
24Chronic mucocutaneous candidiasis (HP:0002728)3.26406274
25Recurrent cutaneous fungal infections (HP:0011370)3.26406274
26Vacuolated lymphocytes (HP:0001922)3.25627559
27Vasculitis (HP:0002633)3.24771497
28Pustule (HP:0200039)3.17015975
29Increased cerebral lipofuscin (HP:0011813)3.12336169
30Keratoconjunctivitis (HP:0001096)3.09833457
31Periodontitis (HP:0000704)3.07313120
32T lymphocytopenia (HP:0005403)3.06558551
33Abnormality of T cell number (HP:0011839)3.04008811
34Increased IgM level (HP:0003496)3.03968133
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.96390048
36Leukocytosis (HP:0001974)2.92799630
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.91577029
38Spontaneous hematomas (HP:0007420)2.85462830
39Hypochromic microcytic anemia (HP:0004840)2.84187358
40Chronic otitis media (HP:0000389)2.80209994
41Abnormality of liposaccharide metabolism (HP:0010968)2.76398898
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.76398898
43Abnormality of glycolipid metabolism (HP:0010969)2.76398898
44Abnormality of T cells (HP:0002843)2.75640999
45Inflammation of the large intestine (HP:0002037)2.72271312
46Hypochromic anemia (HP:0001931)2.70304578
47Petechiae (HP:0000967)2.68771410
48Pulmonary infiltrates (HP:0002113)2.66873088
49Eosinophilia (HP:0001880)2.66694487
50Prolonged bleeding time (HP:0003010)2.62077082
51Pulmonary embolism (HP:0002204)2.61460130
52Gastrointestinal inflammation (HP:0004386)2.60858092
53Glomerulonephritis (HP:0000099)2.60228338
54Panhypogammaglobulinemia (HP:0003139)2.59836820
55Thyroiditis (HP:0100646)2.59490059
56Autoimmune hemolytic anemia (HP:0001890)2.58981700
57Arterial thrombosis (HP:0004420)2.58558818
58Dysostosis multiplex (HP:0000943)2.54782185
59Osteomyelitis (HP:0002754)2.53998751
60Episodic fever (HP:0001954)2.53596218
61Anorexia (HP:0002039)2.51246018
62Disinhibition (HP:0000734)2.48872045
63Colitis (HP:0002583)2.48360451
64Thrombocytosis (HP:0001894)2.48312180
65Basal ganglia calcification (HP:0002135)2.48241332
66Interstitial pulmonary disease (HP:0006530)2.48105639
67Granulocytopenia (HP:0001913)2.47705566
68Urticaria (HP:0001025)2.44732313
69Epistaxis (HP:0000421)2.44661655
70Lymphopenia (HP:0001888)2.42141913
71Abnormality of T cell physiology (HP:0011840)2.41718797
72IgG deficiency (HP:0004315)2.40500860
73Recurrent bronchitis (HP:0002837)2.40319004
74Hemoptysis (HP:0002105)2.40149609
75Gingival bleeding (HP:0000225)2.39889977
76Abnormality of the pleura (HP:0002103)2.39701315
77Agammaglobulinemia (HP:0004432)2.37878598
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.35230334
79Papilloma (HP:0012740)2.34293330
80Verrucae (HP:0200043)2.34293330
81Abnormality of eosinophils (HP:0001879)2.34201447
82Severe combined immunodeficiency (HP:0004430)2.34184997
83Agnosia (HP:0010524)2.32104968
84Peritonitis (HP:0002586)2.31574067
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31479629
86Combined immunodeficiency (HP:0005387)2.30191896
87Nasal polyposis (HP:0100582)2.30087808
88Recurrent pneumonia (HP:0006532)2.30079960
89Hematochezia (HP:0002573)2.29329815
90Microcytic anemia (HP:0001935)2.25669206
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.25064064
92Gangrene (HP:0100758)2.24217427
93Amyloidosis (HP:0011034)2.23677519
94Abnormality of B cell number (HP:0010975)2.20961678
95Chest pain (HP:0100749)2.20204236
96Skin rash (HP:0000988)2.19716824
97Abnormality of the fingertips (HP:0001211)2.19690757
98Keratoconjunctivitis sicca (HP:0001097)2.16966950
99Abnormality of the peritoneum (HP:0002585)2.16715228
100Encephalitis (HP:0002383)2.16104057
101Axonal loss (HP:0003447)2.15073843
102Recurrent sinusitis (HP:0011108)2.14484682
103Recurrent lower respiratory tract infections (HP:0002783)2.14062846
104Purpura (HP:0000979)2.12651843
105Gastrointestinal infarctions (HP:0005244)2.12436836
106Impaired platelet aggregation (HP:0003540)2.10412631
107Abnormal platelet function (HP:0011869)2.10412631
108Chronic diarrhea (HP:0002028)2.09700630
109Osteolytic defects of the hand bones (HP:0009699)2.09107342
110Osteolytic defects of the phalanges of the hand (HP:0009771)2.09107342
111Glomerulopathy (HP:0100820)2.07038308
112Viral hepatitis (HP:0006562)2.06783057
113Abnormality of the nasal mucosa (HP:0000433)2.05612102
114Increased IgE level (HP:0003212)2.04962078
115B lymphocytopenia (HP:0010976)2.04448182
116Spondylolisthesis (HP:0003302)2.04199426
117Skin ulcer (HP:0200042)2.03801655
118Gastrointestinal stroma tumor (HP:0100723)2.03230184
119Acute hepatic failure (HP:0006554)2.03223645
120Hypergammaglobulinemia (HP:0010702)2.02889939
121Sepsis (HP:0100806)2.02818201
122Abnormality of the prostate (HP:0008775)2.02367443
123Prostate neoplasm (HP:0100787)2.00504009
124Mucopolysacchariduria (HP:0008155)1.98386551
125Urinary glycosaminoglycan excretion (HP:0003541)1.98386551
126Spinal cord lesions (HP:0100561)1.97180956
127Restrictive lung disease (HP:0002091)1.97078373
128Abnormality of the endocardium (HP:0004306)1.96839291
129Hepatosplenomegaly (HP:0001433)1.95826475
130Slow saccadic eye movements (HP:0000514)1.93015196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.60270340
2TXK3.45914396
3IRAK43.02597118
4MAP3K142.97099369
5RIPK42.94376793
6BLK2.82836817
7TYK22.67630433
8TBK12.53866734
9IRAK32.41672609
10JAK32.41115665
11TGFBR22.30897718
12ZAP702.24150992
13PRPF4B2.21350838
14IKBKE2.20892311
15KIT2.20087229
16STK102.03360383
17IKBKB1.91061618
18CSF1R1.88193810
19BTK1.85071160
20ERN11.81562676
21JAK11.79411282
22SYK1.70219489
23CSK1.70215825
24TEC1.65021153
25HCK1.64937536
26ITK1.64092743
27LCK1.46117747
28TAOK31.43289000
29CLK11.42035833
30MAP3K111.40449534
31MAP2K31.40310457
32MAP3K31.36513951
33MAP3K131.35893885
34RPS6KA41.33203628
35FES1.32770765
36LYN1.29029949
37MAP3K101.28325338
38TAOK11.26930291
39PIM11.25241313
40CDK121.22816645
41GRK61.22658065
42CAMK1D1.19523858
43EPHB11.14816268
44CHUK1.13349025
45SIK21.12162371
46MAP3K11.10352734
47BMPR21.08160714
48NME21.06443162
49MARK31.04609657
50LRRK21.03296573
51EEF2K1.02826946
52PIM21.02605161
53TRPM71.01187410
54FGFR30.97603914
55JAK20.91287663
56KSR20.89167876
57NEK90.83515347
58CAMK1G0.82364178
59PKN20.81714942
60STK40.81004201
61FGFR40.78526843
62MARK20.77448158
63TAOK20.76232498
64SIK30.74545872
65CDK190.74376396
66SMG10.72810028
67CDK60.67610847
68GRK70.66760460
69TRIB30.66628099
70PRKD20.65629341
71MATK0.63783897
72BRD40.63197192
73MAPK70.62872159
74PDPK10.61243717
75TTN0.61094693
76FGR0.60024132
77TNK20.59900562
78CDK40.59878265
79BMX0.57966074
80YES10.56818396
81PRKCQ0.55090310
82FLT30.54724205
83PAK40.53310178
84MST40.52627116
85RPS6KA60.51729615
86MAP3K70.51645751
87PTK60.51230443
88ABL10.50213958
89EGFR0.49772244
90CDC42BPA0.49703901
91NLK0.49590893
92PTK2B0.48786385
93MAPKAPK20.48477785
94IRAK20.45120001
95CAMKK10.44996719
96PRKCD0.42776769
97CAMKK20.42498610
98MAPK110.41842185
99MAP3K50.41629327
100CDK90.40877372
101MAP2K60.40859936
102MAP3K60.40226943
103RPS6KC10.39571714
104RPS6KL10.39571714
105RAF10.39388091
106STK110.38941738
107SGK30.38036766
108RIPK10.37142709
109STK30.36941478
110KDR0.36543839
111MAP3K20.36156681
112PDK10.35086339
113ALK0.34407267
114PRKCH0.33986138
115FYN0.33275899
116MAPK40.32241678
117TESK20.31783922
118EIF2AK20.31718819
119EPHA30.31556605
120RET0.30179783
121PDGFRB0.29892626
122MAP3K80.29607828
123NEK20.29597102
124SGK20.29023822
125MOS0.27855294
126IGF1R0.27139202
127PIK3CG0.27045578
128MAPK120.26094090
129ATR0.26076814
130HIPK20.25684746
131IRAK10.24776171

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.18976350
2Staphylococcus aureus infection_Homo sapiens_hsa051502.68431308
3Osteoclast differentiation_Homo sapiens_hsa043802.59844637
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.50832161
5Primary immunodeficiency_Homo sapiens_hsa053402.39572937
6B cell receptor signaling pathway_Homo sapiens_hsa046622.28528858
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26475158
8Graft-versus-host disease_Homo sapiens_hsa053322.26037086
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24155754
10Measles_Homo sapiens_hsa051622.20507176
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03557303
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.02515041
13Legionellosis_Homo sapiens_hsa051342.01300808
14Pertussis_Homo sapiens_hsa051331.98208058
15Hematopoietic cell lineage_Homo sapiens_hsa046401.97019230
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.96273585
17Tuberculosis_Homo sapiens_hsa051521.90013174
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87863850
19Antigen processing and presentation_Homo sapiens_hsa046121.87143874
20Malaria_Homo sapiens_hsa051441.80216892
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78891795
22Allograft rejection_Homo sapiens_hsa053301.76223911
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72849443
24Other glycan degradation_Homo sapiens_hsa005111.71734368
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.65641208
26T cell receptor signaling pathway_Homo sapiens_hsa046601.63226899
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.63145138
28Toxoplasmosis_Homo sapiens_hsa051451.56324122
29Herpes simplex infection_Homo sapiens_hsa051681.56041457
30TNF signaling pathway_Homo sapiens_hsa046681.54997431
31Influenza A_Homo sapiens_hsa051641.54691266
32Asthma_Homo sapiens_hsa053101.51315906
33Lysosome_Homo sapiens_hsa041421.48856094
34Chemokine signaling pathway_Homo sapiens_hsa040621.47791649
35Shigellosis_Homo sapiens_hsa051311.45484163
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.43810894
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40464487
38Salmonella infection_Homo sapiens_hsa051321.37742338
39Apoptosis_Homo sapiens_hsa042101.35413558
40Hepatitis B_Homo sapiens_hsa051611.34711795
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.27895876
42Rheumatoid arthritis_Homo sapiens_hsa053231.27198216
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23105881
44Acute myeloid leukemia_Homo sapiens_hsa052211.21945249
45Chronic myeloid leukemia_Homo sapiens_hsa052201.19644289
46Viral myocarditis_Homo sapiens_hsa054161.15059782
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11386983
48Phagosome_Homo sapiens_hsa041451.05305415
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04324789
50Pancreatic cancer_Homo sapiens_hsa052121.03749322
51Type I diabetes mellitus_Homo sapiens_hsa049400.95772093
52* Platelet activation_Homo sapiens_hsa046110.94266231
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92381652
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91869089
55Hepatitis C_Homo sapiens_hsa051600.87160017
56Epstein-Barr virus infection_Homo sapiens_hsa051690.85721678
57Autoimmune thyroid disease_Homo sapiens_hsa053200.85286487
58African trypanosomiasis_Homo sapiens_hsa051430.84739355
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84415778
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.82198667
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82029296
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74063099
63Caffeine metabolism_Homo sapiens_hsa002320.73086716
64HTLV-I infection_Homo sapiens_hsa051660.68795119
65Viral carcinogenesis_Homo sapiens_hsa052030.67051751
66Amoebiasis_Homo sapiens_hsa051460.65118056
67Small cell lung cancer_Homo sapiens_hsa052220.64785557
68Systemic lupus erythematosus_Homo sapiens_hsa053220.59512984
69Prolactin signaling pathway_Homo sapiens_hsa049170.58263158
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57906016
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56756909
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56387431
73DNA replication_Homo sapiens_hsa030300.56238904
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55756188
75Non-small cell lung cancer_Homo sapiens_hsa052230.54903446
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53207210
77Notch signaling pathway_Homo sapiens_hsa043300.52885229
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52865012
79VEGF signaling pathway_Homo sapiens_hsa043700.52243673
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51987673
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.51615466
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50597855
83Colorectal cancer_Homo sapiens_hsa052100.49532300
84Base excision repair_Homo sapiens_hsa034100.49287926
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.47763903
86Non-homologous end-joining_Homo sapiens_hsa034500.47129692
87Dorso-ventral axis formation_Homo sapiens_hsa043200.45688654
88HIF-1 signaling pathway_Homo sapiens_hsa040660.45258782
89p53 signaling pathway_Homo sapiens_hsa041150.44282610
90Endocytosis_Homo sapiens_hsa041440.43967584
91FoxO signaling pathway_Homo sapiens_hsa040680.41238796
92MicroRNAs in cancer_Homo sapiens_hsa052060.39962847
93Endometrial cancer_Homo sapiens_hsa052130.39303880
94Choline metabolism in cancer_Homo sapiens_hsa052310.38559079
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37025615
96GnRH signaling pathway_Homo sapiens_hsa049120.35812763
97Proteoglycans in cancer_Homo sapiens_hsa052050.33963195
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.33018289
99Regulation of autophagy_Homo sapiens_hsa041400.32948304
100Complement and coagulation cascades_Homo sapiens_hsa046100.32180067
101Prostate cancer_Homo sapiens_hsa052150.30931078
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29848124
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29548287
104Insulin resistance_Homo sapiens_hsa049310.29452589
105MAPK signaling pathway_Homo sapiens_hsa040100.27714400
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.27372558
107Homologous recombination_Homo sapiens_hsa034400.25736601
108Renal cell carcinoma_Homo sapiens_hsa052110.25128210
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24391519
110Prion diseases_Homo sapiens_hsa050200.24332047
111Type II diabetes mellitus_Homo sapiens_hsa049300.24028368
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21511693
113Inositol phosphate metabolism_Homo sapiens_hsa005620.20751125
114Pathways in cancer_Homo sapiens_hsa052000.19868782
115mTOR signaling pathway_Homo sapiens_hsa041500.19836446
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19331599

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