AP4M1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)9.32599098
2regulation of histone H3-K27 methylation (GO:0061085)7.99511480
3presynaptic membrane organization (GO:0097090)7.78855031
4postsynaptic membrane organization (GO:0001941)7.65868909
5ribosomal small subunit biogenesis (GO:0042274)6.15392083
6neuron cell-cell adhesion (GO:0007158)5.77147724
7regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)5.55053060
8protein heterotetramerization (GO:0051290)5.33332283
9generation of neurons (GO:0048699)5.13824684
10viral transcription (GO:0019083)5.10937320
11protein complex biogenesis (GO:0070271)4.86398066
12neurotransmitter-gated ion channel clustering (GO:0072578)4.86132636
13interferon-gamma production (GO:0032609)4.84267271
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.82918433
15NADH dehydrogenase complex assembly (GO:0010257)4.82918433
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.82918433
17positive regulation of dendritic spine development (GO:0060999)4.77890487
18translational termination (GO:0006415)4.71820207
19regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.66029189
20chaperone-mediated protein transport (GO:0072321)4.64211483
21mitochondrial respiratory chain complex assembly (GO:0033108)4.59663371
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.57091506
23short-term memory (GO:0007614)4.50989240
24positive regulation of synaptic transmission, GABAergic (GO:0032230)4.41006734
25behavioral response to nicotine (GO:0035095)4.38181232
26membrane assembly (GO:0071709)4.32052086
27regulation of metalloenzyme activity (GO:0048552)4.26967050
28response to folic acid (GO:0051593)4.23875399
29mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.23505998
30positive regulation of synapse assembly (GO:0051965)4.19748360
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.18568452
32axon ensheathment in central nervous system (GO:0032291)4.14943914
33central nervous system myelination (GO:0022010)4.14943914
34protein-cofactor linkage (GO:0018065)4.07766484
35cotranslational protein targeting to membrane (GO:0006613)4.06642856
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04859758
37protein localization to synapse (GO:0035418)4.04770790
38protein targeting to ER (GO:0045047)4.02699644
39transcription elongation from RNA polymerase III promoter (GO:0006385)4.01851959
40termination of RNA polymerase III transcription (GO:0006386)4.01851959
41negative regulation of inclusion body assembly (GO:0090084)3.99552039
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99438541
43mature B cell differentiation (GO:0002335)3.90073092
44respiratory chain complex IV assembly (GO:0008535)3.88962920
45positive regulation of systemic arterial blood pressure (GO:0003084)3.88384315
46positive regulation of mitochondrial fission (GO:0090141)3.88262424
47omega-hydroxylase P450 pathway (GO:0097267)3.88219197
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.87417322
49ribosomal large subunit biogenesis (GO:0042273)3.87241251
50DNA deamination (GO:0045006)3.84662365
51ATP synthesis coupled proton transport (GO:0015986)3.83786158
52energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83786158
53protein localization to endoplasmic reticulum (GO:0070972)3.77713446
54positive regulation of neurotransmitter secretion (GO:0001956)3.73843123
55adult heart development (GO:0007512)3.66979200
56cytochrome complex assembly (GO:0017004)3.65588223
57regulation of ruffle assembly (GO:1900027)3.65543379
58regulation of respiratory system process (GO:0044065)3.64258075
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61306499
60epithelial cilium movement (GO:0003351)3.57437050
61electron transport chain (GO:0022900)3.53930599
62cellular protein complex disassembly (GO:0043624)3.52450288
63respiratory electron transport chain (GO:0022904)3.50911080
64regulation of respiratory gaseous exchange (GO:0043576)3.50019002
65proteasome assembly (GO:0043248)3.47268543
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.46176874
67positive regulation of protein kinase C signaling (GO:0090037)3.45755315
68pseudouridine synthesis (GO:0001522)3.44946455
69positive regulation of membrane potential (GO:0045838)3.39976018
70viral life cycle (GO:0019058)3.39652357
71regulation of mitochondrial translation (GO:0070129)3.35215253
72ubiquinone biosynthetic process (GO:0006744)3.35113815
73anterior/posterior axis specification, embryo (GO:0008595)3.31292123
74translational elongation (GO:0006414)3.31094697
75DNA ligation (GO:0006266)3.30845484
76negative regulation of execution phase of apoptosis (GO:1900118)3.25803737
77regulation of pigment cell differentiation (GO:0050932)3.24796630
78regulation of stem cell maintenance (GO:2000036)3.24693235
79protein neddylation (GO:0045116)3.22823465
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19635977
81rRNA modification (GO:0000154)3.19272543
82ubiquinone metabolic process (GO:0006743)3.17058989
83regulation of cilium movement (GO:0003352)3.16790531
84DNA double-strand break processing (GO:0000729)3.11199408
85protein deneddylation (GO:0000338)3.11100671
86negative regulation of T-helper cell differentiation (GO:0045623)3.08121737
87negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08121737
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07877156
89cullin deneddylation (GO:0010388)3.05873600
90cilium movement (GO:0003341)3.05550934
91regulation of dendritic spine development (GO:0060998)3.05063480
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04653767
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04653767
94vesicle targeting (GO:0006903)3.01264139
95negative regulation of leukocyte chemotaxis (GO:0002689)3.00616785
96sulfate transmembrane transport (GO:1902358)3.00059347
97tRNA processing (GO:0008033)2.99982630
98cellular component biogenesis (GO:0044085)2.98522980
99regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98369751
100activated T cell proliferation (GO:0050798)2.97073211
101base-excision repair, AP site formation (GO:0006285)2.96881077
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.96210635
103axoneme assembly (GO:0035082)2.96192008
104cranial nerve morphogenesis (GO:0021602)2.95909697
105mannosylation (GO:0097502)2.95009139
106negative regulation of alpha-beta T cell differentiation (GO:0046639)2.93776358
107regulation of mitochondrial fission (GO:0090140)2.93549877
108telencephalon development (GO:0021537)2.91323729
109positive regulation of cellular amine metabolic process (GO:0033240)2.91058502
110protein complex disassembly (GO:0043241)2.91010515
111protein K63-linked deubiquitination (GO:0070536)2.90388779
112male meiosis I (GO:0007141)2.89823688
113positive regulation of osteoclast differentiation (GO:0045672)2.89169632
114rRNA methylation (GO:0031167)2.88514114
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88359891
116nonmotile primary cilium assembly (GO:0035058)2.87918248
117oligodendrocyte differentiation (GO:0048709)2.85209992
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.85148473
119regulation of T-helper 2 cell differentiation (GO:0045628)2.83646310
120protein targeting to mitochondrion (GO:0006626)2.82819097
121regulation of synapse assembly (GO:0051963)2.82724530
122DNA damage response, detection of DNA damage (GO:0042769)2.82469976
123melanin metabolic process (GO:0006582)2.81153760
124developmental pigmentation (GO:0048066)2.80133690
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79702166
126enteric nervous system development (GO:0048484)2.78085844
127positive regulation of natural killer cell mediated immunity (GO:0002717)2.74586102
128positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.74586102
129protein localization to mitochondrion (GO:0070585)2.74415368
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74012037
131ncRNA 3-end processing (GO:0043628)2.73913644
132establishment of protein localization to mitochondrion (GO:0072655)2.73609680
133positive regulation of gastrulation (GO:2000543)2.73540060
134preassembly of GPI anchor in ER membrane (GO:0016254)2.73359896
135translational initiation (GO:0006413)2.72818575
136metallo-sulfur cluster assembly (GO:0031163)2.68333855
137iron-sulfur cluster assembly (GO:0016226)2.68333855
138regulation of hexokinase activity (GO:1903299)2.67580570
139regulation of glucokinase activity (GO:0033131)2.67580570
140tRNA modification (GO:0006400)2.67370123
141negative regulation of T cell differentiation in thymus (GO:0033085)2.67062605
142maturation of SSU-rRNA (GO:0030490)2.66901694
143macromolecular complex disassembly (GO:0032984)2.66651493
144positive regulation of oligodendrocyte differentiation (GO:0048714)2.66051653
145DNA replication checkpoint (GO:0000076)2.66029415
146positive regulation of neurotransmitter transport (GO:0051590)2.65879831
147DNA catabolic process, exonucleolytic (GO:0000738)2.64432333
148neuronal action potential propagation (GO:0019227)2.64008040
149protein targeting to membrane (GO:0006612)2.63853685
150pattern specification involved in kidney development (GO:0061004)2.62203273
151positive regulation of calcium ion import (GO:0090280)2.62156286
152transcription from RNA polymerase III promoter (GO:0006383)2.60784610
153sphingoid metabolic process (GO:0046519)2.59969184
154platelet dense granule organization (GO:0060155)2.59461333
155piRNA metabolic process (GO:0034587)2.58924248
156pyrimidine nucleobase catabolic process (GO:0006208)2.58462429
157regulation of natural killer cell mediated immunity (GO:0002715)2.58094128
158regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.58094128
159kinetochore assembly (GO:0051382)2.57855401
160sperm capacitation (GO:0048240)2.56896934
161mitochondrion morphogenesis (GO:0070584)2.56876799
162sulfate transport (GO:0008272)2.55312854
163protein K6-linked ubiquitination (GO:0085020)2.55184765
164intracellular protein transmembrane import (GO:0044743)2.54324804
165intraciliary transport (GO:0042073)2.54299747
166ribosome biogenesis (GO:0042254)2.52920736
167hydrogen ion transmembrane transport (GO:1902600)2.52904589
168water-soluble vitamin biosynthetic process (GO:0042364)2.52614367
169cerebral cortex radially oriented cell migration (GO:0021799)2.52570838
170negative regulation of telomere maintenance (GO:0032205)2.52488363
171maturation of 5.8S rRNA (GO:0000460)2.51531409
172L-fucose metabolic process (GO:0042354)2.51040431
173L-fucose catabolic process (GO:0042355)2.51040431
174fucose catabolic process (GO:0019317)2.51040431
175radial glial cell differentiation (GO:0060019)2.50928721
176translation (GO:0006412)2.50816108
177cornea development in camera-type eye (GO:0061303)2.50164999
178regulation of T-helper 1 cell differentiation (GO:0045625)2.49540975
179recombinational repair (GO:0000725)2.48740168
180regulation of nuclear cell cycle DNA replication (GO:0033262)2.48486550
181polyol transport (GO:0015791)2.47956534
182tRNA metabolic process (GO:0006399)2.47748751
183quinone biosynthetic process (GO:1901663)2.47267736
184ribonucleoprotein complex biogenesis (GO:0022613)2.47094782
185mesonephros development (GO:0001823)2.46828151
186axonemal dynein complex assembly (GO:0070286)2.46798211
187pyrimidine nucleotide catabolic process (GO:0006244)2.46499777
188replication fork processing (GO:0031297)2.45654817
189regulation of synaptic transmission, GABAergic (GO:0032228)2.45632105
190rRNA processing (GO:0006364)2.45424572
191double-strand break repair via homologous recombination (GO:0000724)2.43471968
192DNA methylation involved in gamete generation (GO:0043046)2.43059078
193spliceosomal snRNP assembly (GO:0000387)2.41760298
194rRNA metabolic process (GO:0016072)2.41406365
195proton transport (GO:0015992)2.39764182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.39137782
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.21225264
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13482359
4EZH2_22144423_ChIP-Seq_EOC_Human4.10678464
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.00735687
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.87679785
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71483689
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.63468368
9TAF15_26573619_Chip-Seq_HEK293_Human3.42504900
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.36047187
11IRF1_19129219_ChIP-ChIP_H3396_Human3.33842426
12GBX2_23144817_ChIP-Seq_PC3_Human3.20220106
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.08816717
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02527655
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.93882241
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.92811953
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71014608
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60456503
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.53392338
20* VDR_23849224_ChIP-Seq_CD4+_Human2.29415387
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28557255
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23016160
23PCGF2_27294783_Chip-Seq_NPCs_Mouse2.21929899
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.21031110
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.19782149
26SUZ12_27294783_Chip-Seq_NPCs_Mouse2.19100671
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.17164832
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.17164832
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.17164832
30GABP_19822575_ChIP-Seq_HepG2_Human2.16395174
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.10925010
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.10216938
33BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08054876
34* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.05078216
35NFE2_27457419_Chip-Seq_LIVER_Mouse2.04343136
36CBX2_27304074_Chip-Seq_ESCs_Mouse2.02568386
37CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02101614
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00024293
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98064752
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97544127
41* MYC_18940864_ChIP-ChIP_HL60_Human1.97507167
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92458192
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92186974
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90256044
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.87444663
46DCP1A_22483619_ChIP-Seq_HELA_Human1.87253813
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87191947
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86396746
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81242659
50FOXP3_21729870_ChIP-Seq_TREG_Human1.80108712
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77713392
52* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77293980
53XRN2_22483619_ChIP-Seq_HELA_Human1.76856151
54TTF2_22483619_ChIP-Seq_HELA_Human1.76593269
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76206441
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76206441
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75207844
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75024910
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73824741
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.72671035
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.71053325
62JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70169506
63RNF2_27304074_Chip-Seq_NSC_Mouse1.66619319
64EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.66058752
65IGF1R_20145208_ChIP-Seq_DFB_Human1.65585790
66* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65268641
67P300_18555785_Chip-Seq_ESCs_Mouse1.64093860
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.64044134
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63461239
70P53_22387025_ChIP-Seq_ESCs_Mouse1.62198193
71SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60651843
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59387203
73ELK1_19687146_ChIP-ChIP_HELA_Human1.58150795
74TP53_22573176_ChIP-Seq_HFKS_Human1.57704456
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57493648
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.56666349
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.54286607
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53382175
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53373469
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52499271
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51874189
82ER_23166858_ChIP-Seq_MCF-7_Human1.51271436
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.50434734
84P300_19829295_ChIP-Seq_ESCs_Human1.50271906
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.48436125
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47136260
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46983539
88AR_21572438_ChIP-Seq_LNCaP_Human1.46075210
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.45622983
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.45364748
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44988633
92KDM5A_27292631_Chip-Seq_BREAST_Human1.44879858
93* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43841020
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.42614671
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.41989435
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.41847902
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41189916
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40663901
99MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40612776
100OCT4_18555785_Chip-Seq_ESCs_Mouse1.40153859
101* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39755836
102PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39155537
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38856541
104SOX2_18555785_Chip-Seq_ESCs_Mouse1.37408493
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37387034
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.35625817
107FUS_26573619_Chip-Seq_HEK293_Human1.35104586
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.34003884
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33493955
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.33283863
111ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32294977
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31821228
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31765990
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30967508
115ZFX_18555785_Chip-Seq_ESCs_Mouse1.29924252
116SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28816777
117KLF4_18555785_Chip-Seq_ESCs_Mouse1.28281318
118PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28235077
119E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27035669
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24111550
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.23875343
122* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23674787
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22628065
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22503955
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20764260
126EWS_26573619_Chip-Seq_HEK293_Human1.20669301
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20610910
128PU1_27457419_Chip-Seq_LIVER_Mouse1.19160478
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.19081215
130* FOXP1_21924763_ChIP-Seq_HESCs_Human1.17431478
131CTCF_18555785_Chip-Seq_ESCs_Mouse1.16915173
132* ERA_21632823_ChIP-Seq_H3396_Human1.16622102
133PIAS1_25552417_ChIP-Seq_VCAP_Human1.16160199
134CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15826436
135RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15616435
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15210563
137SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13825797
138ZNF274_21170338_ChIP-Seq_K562_Hela1.12915972
139SMAD_19615063_ChIP-ChIP_OVARY_Human1.10427875
140FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07695708
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06318890
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05755330
143TAF2_19829295_ChIP-Seq_ESCs_Human1.04443032
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04089189
145MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02827090
146REST_21632747_ChIP-Seq_MESCs_Mouse1.02514576
147SMAD4_21799915_ChIP-Seq_A2780_Human1.00993610
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00730456
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00295458
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00079702
151POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00079702
152NCOR_22424771_ChIP-Seq_293T_Human0.98959760
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98327259
154CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97928505
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97327672
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97257743
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.96734831
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.96533151
159SMAD3_21741376_ChIP-Seq_HESCs_Human0.95763845
160TAL1_26923725_Chip-Seq_HPCs_Mouse0.95603163
161RUNX2_22187159_ChIP-Seq_PCA_Human0.95175980
162CTCF_18555785_ChIP-Seq_MESCs_Mouse0.94755254
163VDR_22108803_ChIP-Seq_LS180_Human0.94664636
164P53_21459846_ChIP-Seq_SAOS-2_Human0.93315882
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93161545
166NANOG_20526341_ChIP-Seq_ESCs_Human0.92707102
167REST_18959480_ChIP-ChIP_MESCs_Mouse0.90530651
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.90404735
169PHF8_20622854_ChIP-Seq_HELA_Human0.89716481
170GATA3_21878914_ChIP-Seq_MCF-7_Human0.89649489
171PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89374229
172BCL6_27268052_Chip-Seq_Bcells_Human0.89318057
173E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88728953
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87649762
175GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87639823
176E2F1_20622854_ChIP-Seq_HELA_Human0.87543452
177KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87420597
178MYC_19829295_ChIP-Seq_ESCs_Human0.86614924
179HOXB7_26014856_ChIP-Seq_BT474_Human0.86454092
180ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85786566
181ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84691536
182CIITA_25753668_ChIP-Seq_RAJI_Human0.84649735
183* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84120830
184YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84018886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern7.24104776
2MP0009379_abnormal_foot_pigmentation5.78950281
3MP0003136_yellow_coat_color5.39473649
4MP0004381_abnormal_hair_follicle4.14029692
5MP0006292_abnormal_olfactory_placode3.99531609
6MP0002009_preneoplasia3.83461634
7MP0005409_darkened_coat_color3.78444296
8MP0001188_hyperpigmentation3.72936966
9MP0006276_abnormal_autonomic_nervous2.82702588
10MP0002653_abnormal_ependyma_morphology2.76287152
11MP0004043_abnormal_pH_regulation2.37424053
12MP0003938_abnormal_ear_development2.36635940
13MP0000566_synostosis2.33013277
14MP0005174_abnormal_tail_pigmentation2.20171703
15MP0004133_heterotaxia2.07660207
16MP0008877_abnormal_DNA_methylation2.04067215
17MP0002837_dystrophic_cardiac_calcinosis2.02992771
18MP0003786_premature_aging1.96462110
19MP0003787_abnormal_imprinting1.95519749
20MP0008995_early_reproductive_senescence1.91508048
21MP0002160_abnormal_reproductive_system1.77179685
22MP0008058_abnormal_DNA_repair1.76255585
23MP0002876_abnormal_thyroid_physiology1.73461108
24MP0002234_abnormal_pharynx_morphology1.71795091
25MP0008875_abnormal_xenobiotic_pharmacok1.66666235
26MP0005646_abnormal_pituitary_gland1.57499013
27MP0001968_abnormal_touch/_nociception1.56275711
28MP0003121_genomic_imprinting1.50902387
29MP0003123_paternal_imprinting1.43363533
30MP0003186_abnormal_redox_activity1.37512922
31MP0000015_abnormal_ear_pigmentation1.37400689
32MP0003195_calcinosis1.36713347
33MP0002638_abnormal_pupillary_reflex1.36365009
34MP0000778_abnormal_nervous_system1.34853710
35MP0002177_abnormal_outer_ear1.34613012
36MP0002210_abnormal_sex_determination1.34192810
37MP0000049_abnormal_middle_ear1.33241186
38MP0004142_abnormal_muscle_tone1.31874957
39MP0006036_abnormal_mitochondrial_physio1.30980208
40MP0000372_irregular_coat_pigmentation1.28929669
41MP0002277_abnormal_respiratory_mucosa1.28687844
42MP0003693_abnormal_embryo_hatching1.28513843
43MP0005389_reproductive_system_phenotype1.28250222
44MP0003122_maternal_imprinting1.27862519
45MP0003868_abnormal_feces_composition1.27315229
46MP0004742_abnormal_vestibular_system1.26179428
47MP0002938_white_spotting1.25451347
48MP0005394_taste/olfaction_phenotype1.25208062
49MP0005499_abnormal_olfactory_system1.25208062
50MP0003724_increased_susceptibility_to1.24353831
51MP0002735_abnormal_chemical_nociception1.24066915
52MP0001486_abnormal_startle_reflex1.23835120
53MP0008789_abnormal_olfactory_epithelium1.23503971
54MP0002822_catalepsy1.22871056
55MP0002249_abnormal_larynx_morphology1.22153783
56MP0009745_abnormal_behavioral_response1.22007416
57MP0008872_abnormal_physiological_respon1.21730387
58MP0002557_abnormal_social/conspecific_i1.21390056
59MP0001293_anophthalmia1.19750044
60MP0000631_abnormal_neuroendocrine_gland1.19427913
61MP0004147_increased_porphyrin_level1.19305033
62MP0000427_abnormal_hair_cycle1.19101665
63MP0003646_muscle_fatigue1.18404295
64MP0001764_abnormal_homeostasis1.18037211
65MP0001502_abnormal_circadian_rhythm1.17679925
66MP0000026_abnormal_inner_ear1.17021565
67MP0002751_abnormal_autonomic_nervous1.16372437
68MP0004885_abnormal_endolymph1.14645692
69MP0002064_seizures1.12308721
70MP0010094_abnormal_chromosome_stability1.11838617
71MP0001905_abnormal_dopamine_level1.11499144
72MP0009250_abnormal_appendicular_skeleto1.10468414
73MP0002102_abnormal_ear_morphology1.10226676
74MP0000920_abnormal_myelination1.08799278
75MP0003635_abnormal_synaptic_transmissio1.08400113
76MP0002067_abnormal_sensory_capabilities1.08191403
77MP0006035_abnormal_mitochondrial_morpho1.08161004
78MP0001661_extended_life_span1.07438667
79MP0002272_abnormal_nervous_system1.07172196
80MP0004270_analgesia1.06601862
81MP0005423_abnormal_somatic_nervous1.06234786
82MP0001986_abnormal_taste_sensitivity1.06100026
83MP0001929_abnormal_gametogenesis1.05576624
84MP0002095_abnormal_skin_pigmentation1.03961443
85MP0003011_delayed_dark_adaptation1.02187184
86MP0010030_abnormal_orbit_morphology1.01972919
87MP0009046_muscle_twitch1.00204520
88MP0006072_abnormal_retinal_apoptosis0.99281106
89MP0003698_abnormal_male_reproductive0.98939122
90MP0004924_abnormal_behavior0.98043229
91MP0005386_behavior/neurological_phenoty0.98043229
92MP0005171_absent_coat_pigmentation0.97251087
93MP0004019_abnormal_vitamin_homeostasis0.96965770
94MP0001145_abnormal_male_reproductive0.96700998
95MP0005084_abnormal_gallbladder_morpholo0.95536307
96MP0000653_abnormal_sex_gland0.94497130
97MP0005075_abnormal_melanosome_morpholog0.92400074
98MP0002909_abnormal_adrenal_gland0.92236964
99MP0005379_endocrine/exocrine_gland_phen0.91992089
100MP0005551_abnormal_eye_electrophysiolog0.91959042
101MP0001346_abnormal_lacrimal_gland0.91873300
102MP0005195_abnormal_posterior_eye0.91852950
103MP0001340_abnormal_eyelid_morphology0.90438404
104MP0000681_abnormal_thyroid_gland0.90154272
105MP0002733_abnormal_thermal_nociception0.89921731
106MP0003137_abnormal_impulse_conducting0.89797749
107MP0001485_abnormal_pinna_reflex0.89414479
108MP0001963_abnormal_hearing_physiology0.88346005
109MP0001919_abnormal_reproductive_system0.87702959
110MP0008569_lethality_at_weaning0.87172635
111MP0003878_abnormal_ear_physiology0.86771634
112MP0005377_hearing/vestibular/ear_phenot0.86771634
113MP0003937_abnormal_limbs/digits/tail_de0.86692217
114MP0002184_abnormal_innervation0.85665191
115MP0000613_abnormal_salivary_gland0.83537491
116MP0002572_abnormal_emotion/affect_behav0.83212165
117MP0008007_abnormal_cellular_replicative0.81507129
118MP0004272_abnormal_basement_membrane0.79362407
119MP0002752_abnormal_somatic_nervous0.78774887
120MP0001970_abnormal_pain_threshold0.76361560
121MP0003718_maternal_effect0.76285766
122MP0003763_abnormal_thymus_physiology0.75804038
123MP0005645_abnormal_hypothalamus_physiol0.74823879
124MP0002163_abnormal_gland_morphology0.73718794
125MP0002734_abnormal_mechanical_nocicepti0.73084585
126MP0005623_abnormal_meninges_morphology0.70374000
127MP0001984_abnormal_olfaction0.69777231
128MP0001440_abnormal_grooming_behavior0.69703195
129MP0008057_abnormal_DNA_replication0.68349590
130MP0002736_abnormal_nociception_after0.65953207
131MP0001529_abnormal_vocalization0.65795381
132MP0003941_abnormal_skin_development0.65118510
133MP0002166_altered_tumor_susceptibility0.62280050
134MP0003385_abnormal_body_wall0.61682759
135MP0008260_abnormal_autophagy0.60736379
136MP0003315_abnormal_perineum_morphology0.60187361
137MP0005253_abnormal_eye_physiology0.59462648
138MP0001851_eye_inflammation0.59199318
139MP0003119_abnormal_digestive_system0.58931333
140MP0003866_abnormal_defecation0.58729364
141MP0002882_abnormal_neuron_morphology0.58590434
142MP0001765_abnormal_ion_homeostasis0.56408709
143MP0005381_digestive/alimentary_phenotyp0.55752589
144MP0001501_abnormal_sleep_pattern0.54999434
145MP0000462_abnormal_digestive_system0.54309574
146MP0000465_gastrointestinal_hemorrhage0.54308074
147MP0001286_abnormal_eye_development0.52786876
148MP0002152_abnormal_brain_morphology0.52038330
149MP0003861_abnormal_nervous_system0.51734870
150MP0000762_abnormal_tongue_morphology0.50613186
151MP0002063_abnormal_learning/memory/cond0.50005142

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)4.89212754
2Amelogenesis imperfecta (HP:0000705)4.46338406
3Peripheral hypomyelination (HP:0007182)4.43561750
4Metabolic alkalosis (HP:0200114)4.11174260
5Cone-rod dystrophy (HP:0000548)4.07579947
6Abnormality of renin-angiotensin system (HP:0000847)4.05900686
7Abnormal mitochondria in muscle tissue (HP:0008316)4.02942185
8Decreased circulating renin level (HP:0003351)4.00249318
9Ulnar claw (HP:0001178)3.84949199
10Progressive inability to walk (HP:0002505)3.81288164
11Hyperactive renin-angiotensin system (HP:0000841)3.80890414
12Abnormality of midbrain morphology (HP:0002418)3.72659640
13Molar tooth sign on MRI (HP:0002419)3.72659640
14Abnormality of dental color (HP:0011073)3.69397376
15Pancreatic cysts (HP:0001737)3.63474555
16Macrocytic anemia (HP:0001972)3.62272257
17Progressive macrocephaly (HP:0004481)3.62262203
18Abnormality of chloride homeostasis (HP:0011422)3.61920959
19Optic disc pallor (HP:0000543)3.60525390
20Acute encephalopathy (HP:0006846)3.59937698
21Nonprogressive disorder (HP:0003680)3.59606559
22Increased CSF lactate (HP:0002490)3.56236614
23Pancreatic fibrosis (HP:0100732)3.52558826
24Hepatocellular necrosis (HP:0001404)3.50495448
25Dynein arm defect of respiratory motile cilia (HP:0012255)3.49588003
26Absent/shortened dynein arms (HP:0200106)3.49588003
27Parakeratosis (HP:0001036)3.48773126
28Reticulocytopenia (HP:0001896)3.47450341
29Abnormal ciliary motility (HP:0012262)3.43367055
30Hyponatremia (HP:0002902)3.43163073
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.42524508
32Hepatic necrosis (HP:0002605)3.42455182
33Nephronophthisis (HP:0000090)3.27835469
34Abnormality of the axillary hair (HP:0100134)3.21218709
35Abnormality of secondary sexual hair (HP:0009888)3.21218709
36Sensory axonal neuropathy (HP:0003390)3.19533280
37Progressive external ophthalmoplegia (HP:0000590)3.16545915
38True hermaphroditism (HP:0010459)3.12636490
39Abnormal respiratory motile cilium physiology (HP:0012261)3.04182057
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.99027150
41Abnormal respiratory epithelium morphology (HP:0012253)2.95140048
42Abnormal respiratory motile cilium morphology (HP:0005938)2.95140048
43Concave nail (HP:0001598)2.87029432
44Abnormality of cells of the erythroid lineage (HP:0012130)2.85779265
45Anhidrosis (HP:0000970)2.84536019
46Congenital stationary night blindness (HP:0007642)2.83754413
47Abnormal number of erythroid precursors (HP:0012131)2.83236225
48Cerebral edema (HP:0002181)2.79601179
49Thyroid-stimulating hormone excess (HP:0002925)2.76648305
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75217333
51Microglossia (HP:0000171)2.75097714
52Hypothermia (HP:0002045)2.72735155
53Abnormality of sodium homeostasis (HP:0010931)2.71886237
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.68866043
55Pallor (HP:0000980)2.61330272
56Abnormality of alanine metabolism (HP:0010916)2.59875505
57Hyperalaninemia (HP:0003348)2.59875505
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59875505
59Abnormality of the renal medulla (HP:0100957)2.58261160
60Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.57525972
61Increased serum lactate (HP:0002151)2.57135672
62Aplasia/Hypoplasia of the patella (HP:0006498)2.53713971
63Medial flaring of the eyebrow (HP:0010747)2.52335485
64Focal motor seizures (HP:0011153)2.51749256
65Abnormal rod and cone electroretinograms (HP:0008323)2.50288607
66Lactic acidosis (HP:0003128)2.49438956
67Cystic liver disease (HP:0006706)2.48654069
68Type II lissencephaly (HP:0007260)2.46741774
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43837419
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43837419
71Pendular nystagmus (HP:0012043)2.39480004
72Sclerocornea (HP:0000647)2.38531430
73Triphalangeal thumb (HP:0001199)2.38272580
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37269995
75Chronic hepatic failure (HP:0100626)2.37213116
76Abnormal sex determination (HP:0012244)2.36263205
77Sex reversal (HP:0012245)2.36263205
78Lipid accumulation in hepatocytes (HP:0006561)2.34735507
79Delayed CNS myelination (HP:0002188)2.32566685
80Stomatitis (HP:0010280)2.31934413
81Steppage gait (HP:0003376)2.29777715
82Abnormal drinking behavior (HP:0030082)2.26736390
83Polydipsia (HP:0001959)2.26736390
84Hyperaldosteronism (HP:0000859)2.23986807
85Absent speech (HP:0001344)2.23312354
86Methylmalonic aciduria (HP:0012120)2.22088558
87Chronic obstructive pulmonary disease (HP:0006510)2.21726401
88Obstructive lung disease (HP:0006536)2.21726401
89Patellar aplasia (HP:0006443)2.17434244
90Optic nerve hypoplasia (HP:0000609)2.17217026
91Abolished electroretinogram (ERG) (HP:0000550)2.16933701
92Abnormality of the renal cortex (HP:0011035)2.16278885
93Methylmalonic acidemia (HP:0002912)2.16025044
94Glomerulonephritis (HP:0000099)2.12922684
95Testicular atrophy (HP:0000029)2.12356721
96Gait imbalance (HP:0002141)2.12168976
97Obstructive sleep apnea (HP:0002870)2.11662986
98Respiratory failure (HP:0002878)2.10909425
99Inability to walk (HP:0002540)2.10619380
100Abnormality of the septum pellucidum (HP:0007375)2.10115176
101Fibular aplasia (HP:0002990)2.09295809
102Progressive microcephaly (HP:0000253)2.08374632
103Congenital primary aphakia (HP:0007707)2.07304711
104Absent septum pellucidum (HP:0001331)2.07201216
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.04711727
106Flat occiput (HP:0005469)2.03887636
107Occipital encephalocele (HP:0002085)2.02839170
108Nephrogenic diabetes insipidus (HP:0009806)2.02624235
109Lethargy (HP:0001254)2.02327171
110Postaxial foot polydactyly (HP:0001830)2.01869705
111Short tibia (HP:0005736)2.01770025
112Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00690753
113Renal Fanconi syndrome (HP:0001994)2.00408342
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.99778268
115Rhinitis (HP:0012384)1.99478683
116Attenuation of retinal blood vessels (HP:0007843)1.98718406
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.98462720
118Abnormality of the phalanges of the hallux (HP:0010057)1.94623258
119Anencephaly (HP:0002323)1.93906402
120Adactyly (HP:0009776)1.93527933
121Ketosis (HP:0001946)1.93412423
122Congenital hepatic fibrosis (HP:0002612)1.92343865
123Absent thumb (HP:0009777)1.90851408
124Meckel diverticulum (HP:0002245)1.89814145
125Hypoplasia of the pons (HP:0012110)1.87799712
126Abnormal biliary tract physiology (HP:0012439)1.87434441
127Bile duct proliferation (HP:0001408)1.87434441
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.87277038
129Abnormality of the pons (HP:0007361)1.84002201
130Pachygyria (HP:0001302)1.83040909
131Exercise intolerance (HP:0003546)1.82470423
132Abnormality of the ileum (HP:0001549)1.81895898
133Renal cortical cysts (HP:0000803)1.81118179
134Rib fusion (HP:0000902)1.80849630
135Recurrent cutaneous fungal infections (HP:0011370)1.80248749
136Chronic mucocutaneous candidiasis (HP:0002728)1.80248749
137Asplenia (HP:0001746)1.79908256
138Stage 5 chronic kidney disease (HP:0003774)1.78582348
139Hypoplastic pelvis (HP:0008839)1.78060438
140Atelectasis (HP:0100750)1.77864328
141Hypophosphatemic rickets (HP:0004912)1.77851123
142Aplasia/hypoplasia of the uterus (HP:0008684)1.77344699
143Opisthotonus (HP:0002179)1.76905213
144Vacuolated lymphocytes (HP:0001922)1.76897023
145Hyperglycinemia (HP:0002154)1.76575874
146Increased hepatocellular lipid droplets (HP:0006565)1.75905267
147Broad-based gait (HP:0002136)1.74918849
148Exertional dyspnea (HP:0002875)1.74781165
149Tracheomalacia (HP:0002779)1.74760490
150Preaxial hand polydactyly (HP:0001177)1.74461813
151Microretrognathia (HP:0000308)1.73698598
1523-Methylglutaconic aciduria (HP:0003535)1.73571284
153Septo-optic dysplasia (HP:0100842)1.73277881
154Male pseudohermaphroditism (HP:0000037)1.72903112
155Alkalosis (HP:0001948)1.72635863
156Oligodactyly (HP:0012165)1.72075829
157Abnormality of abdominal situs (HP:0011620)1.71425473
158Abdominal situs inversus (HP:0003363)1.71425473
159Split foot (HP:0001839)1.71357205
160Increased IgM level (HP:0003496)1.70131741
161Meningitis (HP:0001287)1.68053234
162Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67762083
163Dysmetria (HP:0001310)1.65980345
164Congenital ichthyosiform erythroderma (HP:0007431)1.64194994
165Reduced antithrombin III activity (HP:0001976)1.63051958
166Mitochondrial inheritance (HP:0001427)1.62743615
167Fair hair (HP:0002286)1.61538062
168Aplasia/Hypoplasia of the spleen (HP:0010451)1.59924538
169Adrenal hypoplasia (HP:0000835)1.59499604
170Nasolacrimal duct obstruction (HP:0000579)1.58266376
171Type I transferrin isoform profile (HP:0003642)1.56237716
172Retinal dysplasia (HP:0007973)1.55882145
173Cheilitis (HP:0100825)1.55611905
174Acute necrotizing encephalopathy (HP:0006965)1.55248913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.86095275
2PRKD24.77273298
3STK384.18073592
4BCKDK3.50023420
5CLK13.33155909
6TSSK63.23135387
7TLK13.08696723
8TNIK3.07064779
9MAPK152.80673268
10FRK2.63940838
11MAP4K22.58646065
12VRK22.51480161
13ZAK2.48909752
14FGR2.47834525
15STK392.40331364
16PLK42.26513448
17NLK2.23079659
18BUB12.17840753
19INSRR2.14259752
20MST42.05992693
21UHMK11.92249451
22TRIM281.90502973
23STK111.81790914
24IRAK41.74958105
25MKNK21.74303545
26PINK11.66795184
27HIPK21.66469863
28IRAK11.65485858
29WNK31.65058833
30IRAK21.63737396
31NME21.62622480
32YES11.58332436
33GRK71.52618217
34TXK1.49248211
35MUSK1.49001395
36GRK61.48931216
37SRPK11.47921381
38IRAK31.42060638
39PDK21.39573631
40FES1.36435892
41NUAK11.28494264
42VRK11.27313093
43MAPKAPK51.15829209
44PHKG21.14486364
45PHKG11.14486364
46LIMK11.11108131
47CAMK2B1.10679225
48PIM21.10456495
49CDC71.09731408
50PNCK1.08812058
51PRKCI1.06935540
52MARK11.06010502
53WNK41.00652999
54BLK1.00489616
55MAP3K41.00236447
56WNK10.98973303
57OXSR10.97946439
58MAPKAPK30.95422363
59PLK10.95268141
60MKNK10.91892364
61STK160.90947949
62EIF2AK10.89288077
63BMPR1B0.88859513
64CDK190.83624523
65CSNK1G10.82030854
66CDK80.80992334
67NEK10.80905985
68PRKD10.79151348
69PRKCG0.78709465
70EIF2AK20.78112684
71ABL20.77344672
72AURKA0.76667733
73CDK30.76084291
74EPHA20.75812922
75CSK0.72429550
76CAMK2A0.71839875
77PLK30.71088471
78NEK20.70721070
79ADRBK20.69913933
80CHEK20.69396908
81CCNB10.69387092
82PBK0.68056409
83PKN10.66090030
84RPS6KA40.65198584
85ATR0.64570774
86DYRK20.62984107
87PRKCE0.61966612
88CSNK1A10.60513436
89PAK30.60471881
90DYRK1B0.58645818
91TGFBR10.57998289
92EIF2AK30.57949512
93MAP2K70.57769333
94BMPR20.57310584
95EPHB10.55798450
96CSNK2A10.54986944
97TEC0.54453121
98GRK50.53451913
99AURKB0.53420736
100PRPF4B0.53202564
101PASK0.52222172
102EPHA40.52097200
103CSNK1G30.51942713
104TNK20.51484725
105DAPK20.51413749
106PLK20.50290990
107WEE10.49691967
108DAPK10.49079763
109CSNK2A20.48840212
110TESK10.48660480
111NME10.47988442
112MAPK130.47048378
113ILK0.46323412
114NEK60.46005092
115DYRK30.45609870
116ERBB30.44765798
117MAP4K10.44415797
118IKBKB0.44329127
119GRK10.43346553
120CSNK1A1L0.42574811
121DYRK1A0.42022555
122RPS6KA50.41696035
123CAMK2D0.40914839
124LYN0.40628866
125EPHB20.40117273
126LCK0.39481592
127CSNK1E0.38690892
128TESK20.37647338
129ADRBK10.37355369
130NTRK30.36651657
131PRKCQ0.35825652
132CHUK0.35518908
133EPHA30.33739229
134PIM10.33338042
135RIPK40.33015594
136ATM0.32347586
137PRKCA0.32171140
138MINK10.31598562
139BCR0.31366404
140PRKCZ0.30702586
141STK100.27158199
142TAOK30.25676837
143MAP3K140.25316110
144MAPK100.24793262
145SIK20.24758590
146IKBKE0.23694565
147CDK140.23498941
148CSNK1G20.22224710
149SGK2230.21085579
150SGK4940.21085579
151CDK50.20147426
152ITK0.19695308
153FER0.19676257
154PRKACA0.19616942
155ABL10.19488874
156CAMK2G0.18583098
157BTK0.18241240
158HCK0.18059971

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.65946962
2Ether lipid metabolism_Homo sapiens_hsa005653.15094189
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.82298822
4Nicotine addiction_Homo sapiens_hsa050332.51822038
5Proteasome_Homo sapiens_hsa030502.50529876
6Protein export_Homo sapiens_hsa030602.31912548
7Oxidative phosphorylation_Homo sapiens_hsa001902.12450062
8Base excision repair_Homo sapiens_hsa034102.07003526
9Thyroid cancer_Homo sapiens_hsa052161.97184807
10Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.94754093
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.93114028
12Graft-versus-host disease_Homo sapiens_hsa053321.89023160
13Sphingolipid metabolism_Homo sapiens_hsa006001.86023268
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75561565
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74989626
16Phototransduction_Homo sapiens_hsa047441.69563140
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.69306349
18Basal cell carcinoma_Homo sapiens_hsa052171.52447083
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51307165
20Mismatch repair_Homo sapiens_hsa034301.51049111
21Long-term depression_Homo sapiens_hsa047301.50446071
22Spliceosome_Homo sapiens_hsa030401.49825463
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42811543
24Alzheimers disease_Homo sapiens_hsa050101.41516098
25Wnt signaling pathway_Homo sapiens_hsa043101.41240942
26RNA degradation_Homo sapiens_hsa030181.39364308
27Nucleotide excision repair_Homo sapiens_hsa034201.36771769
28Morphine addiction_Homo sapiens_hsa050321.36234652
29Parkinsons disease_Homo sapiens_hsa050121.36031900
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35495725
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29414875
32Huntingtons disease_Homo sapiens_hsa050161.29296925
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28813149
34Axon guidance_Homo sapiens_hsa043601.27993578
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27257607
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.27236755
37Serotonergic synapse_Homo sapiens_hsa047261.24396007
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22397754
39Collecting duct acid secretion_Homo sapiens_hsa049661.21781550
40Selenocompound metabolism_Homo sapiens_hsa004501.20714849
41Primary immunodeficiency_Homo sapiens_hsa053401.19796243
42Regulation of autophagy_Homo sapiens_hsa041401.17168767
43Purine metabolism_Homo sapiens_hsa002301.17068851
44Antigen processing and presentation_Homo sapiens_hsa046121.16225566
45Fanconi anemia pathway_Homo sapiens_hsa034601.15092315
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14704062
47One carbon pool by folate_Homo sapiens_hsa006701.13788805
48Folate biosynthesis_Homo sapiens_hsa007901.13408446
49Taste transduction_Homo sapiens_hsa047421.13303783
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.10439534
51Melanogenesis_Homo sapiens_hsa049161.09450263
52Fatty acid elongation_Homo sapiens_hsa000621.09427728
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08451896
54Prostate cancer_Homo sapiens_hsa052151.08166381
55Butanoate metabolism_Homo sapiens_hsa006501.07453534
56Homologous recombination_Homo sapiens_hsa034401.06606063
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04777894
58Measles_Homo sapiens_hsa051621.03760150
59Glutamatergic synapse_Homo sapiens_hsa047241.03418533
60Basal transcription factors_Homo sapiens_hsa030221.03212374
61Arachidonic acid metabolism_Homo sapiens_hsa005901.01642105
62Nitrogen metabolism_Homo sapiens_hsa009101.01168901
63Peroxisome_Homo sapiens_hsa041461.00258501
64Tryptophan metabolism_Homo sapiens_hsa003800.99742959
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97705262
66Inositol phosphate metabolism_Homo sapiens_hsa005620.96779424
67GABAergic synapse_Homo sapiens_hsa047270.96765027
68Choline metabolism in cancer_Homo sapiens_hsa052310.96338005
69Other glycan degradation_Homo sapiens_hsa005110.95440588
70Linoleic acid metabolism_Homo sapiens_hsa005910.95332322
71Pancreatic secretion_Homo sapiens_hsa049720.94350506
72RNA transport_Homo sapiens_hsa030130.93869115
73RNA polymerase_Homo sapiens_hsa030200.93824802
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90983178
75Caffeine metabolism_Homo sapiens_hsa002320.90188691
76Sulfur relay system_Homo sapiens_hsa041220.89891699
77Metabolic pathways_Homo sapiens_hsa011000.89757029
78Propanoate metabolism_Homo sapiens_hsa006400.88941263
79Autoimmune thyroid disease_Homo sapiens_hsa053200.86219505
80beta-Alanine metabolism_Homo sapiens_hsa004100.86023895
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82875431
82Acute myeloid leukemia_Homo sapiens_hsa052210.81870448
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81373311
84T cell receptor signaling pathway_Homo sapiens_hsa046600.79585344
85Steroid biosynthesis_Homo sapiens_hsa001000.75128838
86Amphetamine addiction_Homo sapiens_hsa050310.67867809
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67568594
88Glutathione metabolism_Homo sapiens_hsa004800.67325013
89Renin secretion_Homo sapiens_hsa049240.67131468
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.67090893
91Cardiac muscle contraction_Homo sapiens_hsa042600.66678292
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66541292
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.66126705
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.64984424
95Colorectal cancer_Homo sapiens_hsa052100.64199148
96Salivary secretion_Homo sapiens_hsa049700.63565901
97DNA replication_Homo sapiens_hsa030300.61866641
98Cysteine and methionine metabolism_Homo sapiens_hsa002700.61076450
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.60348145
100Dopaminergic synapse_Homo sapiens_hsa047280.59624144
101Insulin secretion_Homo sapiens_hsa049110.59567680
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59553184
103Calcium signaling pathway_Homo sapiens_hsa040200.58430379
104Mineral absorption_Homo sapiens_hsa049780.58073722
105Hematopoietic cell lineage_Homo sapiens_hsa046400.57898552
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57202907
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.56858113
108Cocaine addiction_Homo sapiens_hsa050300.56297569
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56279945
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55993511
111Synaptic vesicle cycle_Homo sapiens_hsa047210.55215088
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53051829
113Pyruvate metabolism_Homo sapiens_hsa006200.52243327
114Pyrimidine metabolism_Homo sapiens_hsa002400.50881024
115Histidine metabolism_Homo sapiens_hsa003400.49585155
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46600908
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46148571
118Allograft rejection_Homo sapiens_hsa053300.46077072
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.45018474
120Olfactory transduction_Homo sapiens_hsa047400.44808141
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44533155
122Long-term potentiation_Homo sapiens_hsa047200.44295716
123Chemical carcinogenesis_Homo sapiens_hsa052040.42858097
124Hedgehog signaling pathway_Homo sapiens_hsa043400.42622738
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42587439
126Cholinergic synapse_Homo sapiens_hsa047250.42566158
127Ras signaling pathway_Homo sapiens_hsa040140.42411340
128Non-homologous end-joining_Homo sapiens_hsa034500.42265591
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42052287
130cAMP signaling pathway_Homo sapiens_hsa040240.40646823
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39812640
132Fatty acid metabolism_Homo sapiens_hsa012120.39715509
133MAPK signaling pathway_Homo sapiens_hsa040100.38844801
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37629054
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.37469062
136Adherens junction_Homo sapiens_hsa045200.36005626
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35464945
138Endometrial cancer_Homo sapiens_hsa052130.35245521
139Sulfur metabolism_Homo sapiens_hsa009200.34711401
140Circadian entrainment_Homo sapiens_hsa047130.34425866
141Fatty acid degradation_Homo sapiens_hsa000710.34209464
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32228257
143Pathways in cancer_Homo sapiens_hsa052000.32211818
144Vibrio cholerae infection_Homo sapiens_hsa051100.31976348
145Asthma_Homo sapiens_hsa053100.28435944
146N-Glycan biosynthesis_Homo sapiens_hsa005100.28362562
147Alcoholism_Homo sapiens_hsa050340.28049140
148Vitamin digestion and absorption_Homo sapiens_hsa049770.27393011
149Arginine and proline metabolism_Homo sapiens_hsa003300.25529397
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.24171120
151p53 signaling pathway_Homo sapiens_hsa041150.19051576

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