AP4E1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.93018427
2nuclear pore organization (GO:0006999)5.38886165
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.56158567
4hepatocyte apoptotic process (GO:0097284)4.55350231
5interferon-gamma production (GO:0032609)4.35074873
6histone H3-K4 trimethylation (GO:0080182)4.18102372
7regulation of centriole replication (GO:0046599)4.17397944
8pore complex assembly (GO:0046931)4.15239807
9positive regulation of mitotic sister chromatid separation (GO:1901970)4.07297043
10positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.07297043
11positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.07297043
12intestinal epithelial cell development (GO:0060576)3.91413838
13mitotic sister chromatid cohesion (GO:0007064)3.73858525
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.71521696
15cytoplasmic mRNA processing body assembly (GO:0033962)3.69464286
16regulation of establishment of cell polarity (GO:2000114)3.61748686
17protein localization to microtubule (GO:0035372)3.59396603
18positive regulation of alpha-beta T cell proliferation (GO:0046641)3.52420587
19negative regulation of DNA repair (GO:0045738)3.44214855
20hemidesmosome assembly (GO:0031581)3.43858558
21regulation of centrosome duplication (GO:0010824)3.31424319
22regulation of sister chromatid cohesion (GO:0007063)3.29981921
23UDP-N-acetylglucosamine metabolic process (GO:0006047)3.26662539
24centriole assembly (GO:0098534)3.26014002
25iron ion import (GO:0097286)3.21842449
26regulation of histone H3-K27 methylation (GO:0061085)3.20667183
27limb bud formation (GO:0060174)3.20492645
28meiotic chromosome segregation (GO:0045132)3.14641905
29regulation of interleukin-2 biosynthetic process (GO:0045076)3.12246258
30keratinocyte development (GO:0003334)3.12245716
31DNA unwinding involved in DNA replication (GO:0006268)3.10874535
32regulation of alpha-beta T cell proliferation (GO:0046640)3.09796782
33centriole replication (GO:0007099)3.08042813
34striated muscle atrophy (GO:0014891)3.07914162
35regulation of activation of Janus kinase activity (GO:0010533)3.07053947
36regulation of RNA export from nucleus (GO:0046831)3.05886846
37histone-serine phosphorylation (GO:0035404)3.05083090
38negative T cell selection (GO:0043383)3.03170556
39ether lipid metabolic process (GO:0046485)3.02287315
40negative regulation of fibroblast apoptotic process (GO:2000270)3.00699491
41myoblast differentiation (GO:0045445)2.98463226
42cellular response to interleukin-15 (GO:0071350)2.97202286
43negative thymic T cell selection (GO:0045060)2.96482252
44regulation of timing of cell differentiation (GO:0048505)2.95332044
45monoubiquitinated protein deubiquitination (GO:0035520)2.95277809
46regulation of B cell receptor signaling pathway (GO:0050855)2.95145190
47skeletal muscle adaptation (GO:0043501)2.93495306
48superoxide anion generation (GO:0042554)2.92891314
49regulation of centrosome cycle (GO:0046605)2.92589773
50regulation of isotype switching to IgG isotypes (GO:0048302)2.92546943
51nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.91488844
52early endosome to late endosome transport (GO:0045022)2.89657201
53protein localization to microtubule cytoskeleton (GO:0072698)2.88574822
54negative regulation of DNA-dependent DNA replication (GO:2000104)2.88556744
55mammary gland epithelial cell proliferation (GO:0033598)2.87020207
56CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.86964960
57T-helper cell differentiation (GO:0042093)2.86964960
58G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.85736263
59cell adhesion mediated by integrin (GO:0033627)2.82449469
60DNA duplex unwinding (GO:0032508)2.82277994
61DNA geometric change (GO:0032392)2.81216007
62positive regulation of keratinocyte differentiation (GO:0045618)2.80315718
63regulation of transforming growth factor beta1 production (GO:0032908)2.80202737
64interkinetic nuclear migration (GO:0022027)2.79249542
65regulation of memory T cell differentiation (GO:0043380)2.78741669
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78622385
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.78622385
68regulation of translation, ncRNA-mediated (GO:0045974)2.78622385
69positive regulation of macroautophagy (GO:0016239)2.78330165
70oligosaccharide catabolic process (GO:0009313)2.78051102
71positive regulation of interleukin-2 production (GO:0032743)2.76025541
72sister chromatid segregation (GO:0000819)2.75559644
73positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.74714574
74positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.74020573
75presynaptic membrane assembly (GO:0097105)2.73485758
76muscle atrophy (GO:0014889)2.73302438
77regulation of establishment or maintenance of cell polarity (GO:0032878)2.73156058
78mitotic nuclear envelope disassembly (GO:0007077)2.72888495
79macroautophagy (GO:0016236)2.72480990
80COPII vesicle coating (GO:0048208)2.72167728
81T cell differentiation involved in immune response (GO:0002292)2.70758065
82alpha-beta T cell differentiation involved in immune response (GO:0002293)2.70758065
83alpha-beta T cell activation involved in immune response (GO:0002287)2.70758065
84N-terminal protein amino acid acetylation (GO:0006474)2.70397238
85protein heterotetramerization (GO:0051290)2.69946082
86response to UV-C (GO:0010225)2.69192553
87microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.68841621
88positive regulation of chromosome segregation (GO:0051984)2.68108709
89detection of other organism (GO:0098543)2.66644048
90protein localization to cytoskeleton (GO:0044380)2.66477497
91regulation of transforming growth factor beta2 production (GO:0032909)2.65584878
92regulation of protein polyubiquitination (GO:1902914)2.65063539
93DNA synthesis involved in DNA repair (GO:0000731)2.64483441
94ribosome assembly (GO:0042255)2.63769233
95maturation of 5.8S rRNA (GO:0000460)2.62841464
96alpha-beta T cell differentiation (GO:0046632)2.61744797
97regulation of fibroblast apoptotic process (GO:2000269)2.61741506
98CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.61424243
99regulation of keratinocyte differentiation (GO:0045616)2.60132377
100negative regulation of T cell mediated immunity (GO:0002710)2.59356376
101detection of bacterium (GO:0016045)2.57742860
102startle response (GO:0001964)2.57616374
103chondrocyte development (GO:0002063)2.57517960
104double-strand break repair via nonhomologous end joining (GO:0006303)2.57120089
105non-recombinational repair (GO:0000726)2.57120089
106regulation of nucleobase-containing compound transport (GO:0032239)2.56343088
107mitotic chromosome condensation (GO:0007076)2.56308115
108pericardium development (GO:0060039)2.56247333
109desmosome organization (GO:0002934)2.56239304
110membrane disassembly (GO:0030397)2.55273466
111nuclear envelope disassembly (GO:0051081)2.55273466
112regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54162992
113ER overload response (GO:0006983)2.54060960
114presynaptic membrane organization (GO:0097090)2.53114919
115cellular response to ethanol (GO:0071361)2.52722102
116regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.52649972
117regulation of Rac protein signal transduction (GO:0035020)2.52618595
118replicative senescence (GO:0090399)2.51735920
119histone H2B ubiquitination (GO:0033523)2.51566384
120peptidyl-lysine trimethylation (GO:0018023)2.51283123
121establishment of protein localization to vacuole (GO:0072666)2.50685735
122protein targeting to vacuole (GO:0006623)2.50685735
123protein targeting to lysosome (GO:0006622)2.50685735
124neutrophil activation (GO:0042119)2.50403085
125energy homeostasis (GO:0097009)2.49688255
126membrane budding (GO:0006900)2.49404207
127cytoskeleton-dependent cytokinesis (GO:0061640)2.49285504
128regulation of development, heterochronic (GO:0040034)2.48945130
129activated T cell proliferation (GO:0050798)2.48726516
130developmental pigmentation (GO:0048066)2.47619958
131response to X-ray (GO:0010165)2.47133938
132DNA ligation (GO:0006266)2.47026138
133regulation of translation in response to stress (GO:0043555)2.46949483
134positive regulation of histone H3-K4 methylation (GO:0051571)2.46669521
135regulation of platelet aggregation (GO:0090330)2.45209136
136embryonic process involved in female pregnancy (GO:0060136)2.44897916
137positive regulation of cellular amide metabolic process (GO:0034250)2.43641650
138mitochondrial DNA replication (GO:0006264)2.43002898
139positive regulation of DNA recombination (GO:0045911)2.42346673
140positive regulation of insulin receptor signaling pathway (GO:0046628)2.42163277
141pyrimidine dimer repair (GO:0006290)2.41909481
142mesenchymal cell differentiation involved in renal system development (GO:2001012)2.41709928
143mesenchymal cell differentiation involved in kidney development (GO:0072161)2.41709928
144cell-substrate junction assembly (GO:0007044)2.41144575
145positive regulation of gamma-delta T cell activation (GO:0046645)2.40175374
146positive regulation of translational initiation (GO:0045948)2.39619401
147neutrophil activation involved in immune response (GO:0002283)2.39600909
148alpha-beta T cell activation (GO:0046631)2.39463573
149positive regulation of response to nutrient levels (GO:0032109)2.38508050
150positive regulation of response to extracellular stimulus (GO:0032106)2.38508050
151regulation of DNA damage checkpoint (GO:2000001)2.35263044
152positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.34650671
153regulation of protein heterodimerization activity (GO:0043497)2.34547166
154negative regulation of mast cell activation (GO:0033004)2.33773432
155regulation of germinal center formation (GO:0002634)2.33164748
156attachment of spindle microtubules to kinetochore (GO:0008608)2.32297020
157regulation of NIK/NF-kappaB signaling (GO:1901222)2.32132284
158NLS-bearing protein import into nucleus (GO:0006607)2.31503494
159germinal center formation (GO:0002467)2.31087311
160mitotic sister chromatid segregation (GO:0000070)2.31054893
161negative regulation of keratinocyte proliferation (GO:0010839)2.30962444
162long-chain fatty acid biosynthetic process (GO:0042759)2.30592337
163T cell migration (GO:0072678)2.29310522
164CD4-positive, alpha-beta T cell activation (GO:0035710)2.29073597
165T cell selection (GO:0045058)2.27148920
166central nervous system myelination (GO:0022010)2.26943837
167axon ensheathment in central nervous system (GO:0032291)2.26943837
168regulation of isotype switching (GO:0045191)2.26273108
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.25935136
170B cell homeostasis (GO:0001782)2.24858965
171regulation of interleukin-2 production (GO:0032663)2.24815047
172purinergic nucleotide receptor signaling pathway (GO:0035590)2.24099836
173histone H3-K9 methylation (GO:0051567)2.23641793
174negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.23277021
175negative regulation of cell killing (GO:0031342)2.23277021
176mitotic G2 DNA damage checkpoint (GO:0007095)2.21903630
177microtubule depolymerization (GO:0007019)2.21174929
178female gonad development (GO:0008585)2.19086820
179response to interleukin-15 (GO:0070672)2.18691989
180mitotic G2/M transition checkpoint (GO:0044818)2.18591325
181negative regulation of homotypic cell-cell adhesion (GO:0034111)2.16185198
182T cell differentiation (GO:0030217)2.15124073
183GPI anchor biosynthetic process (GO:0006506)2.14080084
184positive regulation of T cell cytokine production (GO:0002726)2.13976138
185retina layer formation (GO:0010842)2.13948123
186granulocyte activation (GO:0036230)2.13536513
187regulation of antigen processing and presentation (GO:0002577)2.13491193
188leukocyte aggregation (GO:0070486)2.13012207
189positive regulation of isotype switching (GO:0045830)2.12928099
190positive regulation of interleukin-17 production (GO:0032740)2.12672407
191V(D)J recombination (GO:0033151)2.12600565
192histone H3-K36 demethylation (GO:0070544)2.12531170
193protein K6-linked ubiquitination (GO:0085020)2.12136003
194thymic T cell selection (GO:0045061)2.11896448
195T cell activation involved in immune response (GO:0002286)2.11021172
196dendritic cell migration (GO:0036336)2.09794026
197positive regulation of interleukin-10 production (GO:0032733)2.09734616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50862716
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.03055671
3GBX2_23144817_ChIP-Seq_PC3_Human3.24908977
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.90798184
5GATA1_22025678_ChIP-Seq_K562_Human2.82825585
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79074337
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.71114994
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.67028472
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.66655572
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64039110
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59931387
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58322893
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44676381
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.40238295
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34753350
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34202924
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32990161
18SUZ12_27294783_Chip-Seq_NPCs_Mouse2.26701989
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.26636392
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.18226065
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.13553675
22NFE2_27457419_Chip-Seq_LIVER_Mouse2.11440914
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.09048679
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.07989991
25ELK1_19687146_ChIP-ChIP_HELA_Human2.03119316
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02571802
27TAF15_26573619_Chip-Seq_HEK293_Human1.97993881
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.93824912
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.92848643
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91185320
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.90977111
32BRD4_25478319_ChIP-Seq_HGPS_Human1.88921773
33* NANOG_18555785_Chip-Seq_ESCs_Mouse1.87125611
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83468141
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82920059
36E2F1_18555785_Chip-Seq_ESCs_Mouse1.80632505
37* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.79392194
38* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.78154677
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.78154677
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.77797737
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77278015
42* P300_19829295_ChIP-Seq_ESCs_Human1.76723864
43* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76528213
44* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74637922
45P53_22387025_ChIP-Seq_ESCs_Mouse1.74331019
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.70463047
47* STAT3_18555785_Chip-Seq_ESCs_Mouse1.69978707
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.69817828
49FUS_26573619_Chip-Seq_HEK293_Human1.69650394
50AR_21909140_ChIP-Seq_LNCAP_Human1.68785942
51* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.67470242
52* CMYC_18555785_Chip-Seq_ESCs_Mouse1.67173961
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63706857
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61706345
55* NMYC_18555785_Chip-Seq_ESCs_Mouse1.61193553
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61091431
57* P300_18555785_Chip-Seq_ESCs_Mouse1.60825321
58EWS_26573619_Chip-Seq_HEK293_Human1.59730734
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59135072
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.58886329
61* OCT4_18555785_Chip-Seq_ESCs_Mouse1.57755581
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57276166
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56696383
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.56250992
65* AHR_22903824_ChIP-Seq_MCF-7_Human1.55762725
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.55000086
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54328816
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53230726
69* E2F1_21310950_ChIP-Seq_MCF-7_Human1.52808887
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51194626
71* SOX2_18555785_Chip-Seq_ESCs_Mouse1.50850279
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50839643
73* ER_23166858_ChIP-Seq_MCF-7_Human1.50631476
74WT1_19549856_ChIP-ChIP_CCG9911_Human1.50413727
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50222204
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48254165
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.47348182
78* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45572038
79ZFX_18555785_Chip-Seq_ESCs_Mouse1.44533288
80PU1_27457419_Chip-Seq_LIVER_Mouse1.44528288
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43392256
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42684206
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41948956
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41704886
85CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41151631
86* KLF4_18555785_Chip-Seq_ESCs_Mouse1.40815749
87TP53_16413492_ChIP-PET_HCT116_Human1.40109795
88EZH2_22144423_ChIP-Seq_EOC_Human1.39447779
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39114413
90CRX_20693478_ChIP-Seq_RETINA_Mouse1.38389811
91* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.37848516
92SALL4_18804426_ChIP-ChIP_XEN_Mouse1.37255695
93OCT4_21477851_ChIP-Seq_ESCs_Mouse1.36459367
94RNF2_27304074_Chip-Seq_NSC_Mouse1.36341715
95* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.34903369
96VDR_22108803_ChIP-Seq_LS180_Human1.34675239
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.34515810
98SMAD4_21799915_ChIP-Seq_A2780_Human1.34432834
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33018209
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33018209
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32894460
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.32796551
103* CTCF_18555785_Chip-Seq_ESCs_Mouse1.31723157
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30823967
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30758789
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30648064
107RUNX_20019798_ChIP-Seq_JUKART_Human1.30636702
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.28543098
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28276507
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.27568472
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26710993
112IGF1R_20145208_ChIP-Seq_DFB_Human1.26486514
113* ARNT_22903824_ChIP-Seq_MCF-7_Human1.25701418
114CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23805616
115NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22292697
116NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22292697
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.21394066
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19143361
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19043117
120CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18946707
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18246667
122TCF4_23295773_ChIP-Seq_U87_Human1.17627227
123CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17489076
124IRF1_19129219_ChIP-ChIP_H3396_Human1.17433705
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17177111
126CJUN_26792858_Chip-Seq_BT549_Human1.16990585
127TP53_18474530_ChIP-ChIP_U2OS_Human1.16681768
128TFEB_21752829_ChIP-Seq_HELA_Human1.16549072
129* STAT3_23295773_ChIP-Seq_U87_Human1.16434766
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14696216
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13903108
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13605206
133NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11063668
134JARID2_20064375_ChIP-Seq_MESCs_Mouse1.10402380
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09685925
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06874061
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06636641
138IRF8_27001747_Chip-Seq_BMDM_Mouse1.06173964
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05874513
140Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05490984
141CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05146940
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04268076
143PRDM14_20953172_ChIP-Seq_ESCs_Human1.04190659
144TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02029529
145GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01695017
146PU_27001747_Chip-Seq_BMDM_Mouse1.00858818
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98863338
148TP63_23658742_ChIP-Seq_EP156T_Human0.97444240
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97298837
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96328851
151DCP1A_22483619_ChIP-Seq_HELA_Human0.95636907
152* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95495532
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.94463206
154CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93464572
155HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92666402
156TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92062039
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.91031147
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89971657
159NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88879868
160* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86850503
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.86569138
162CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84585673
163CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83684820
164VDR_23849224_ChIP-Seq_CD4+_Human0.82322737
165CHD1_26751641_Chip-Seq_LNCaP_Human0.81505317
166SOX17_20123909_ChIP-Seq_XEN_Mouse0.79587543

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.75429673
2MP0001188_hyperpigmentation3.36544166
3MP0002877_abnormal_melanocyte_morpholog3.15190712
4MP0003787_abnormal_imprinting3.13953828
5MP0006292_abnormal_olfactory_placode3.03198421
6MP0010352_gastrointestinal_tract_polyps2.96343527
7MP0004381_abnormal_hair_follicle2.88591838
8MP0003705_abnormal_hypodermis_morpholog2.83969637
9MP0005171_absent_coat_pigmentation2.74630280
10MP0000566_synostosis2.67828644
11MP0008057_abnormal_DNA_replication2.41206695
12MP0003763_abnormal_thymus_physiology2.37157031
13MP0005671_abnormal_response_to2.34454564
14MP0010234_abnormal_vibrissa_follicle2.31666003
15MP0003566_abnormal_cell_adhesion2.16184414
16MP0006054_spinal_hemorrhage2.12513004
17MP0000015_abnormal_ear_pigmentation2.11514349
18MP0002102_abnormal_ear_morphology2.08603367
19MP0001835_abnormal_antigen_presentation2.04180516
20MP0009697_abnormal_copulation2.01001660
21MP0000427_abnormal_hair_cycle1.98784512
22MP0008438_abnormal_cutaneous_collagen1.97364744
23MP0008058_abnormal_DNA_repair1.96684011
24MP0005387_immune_system_phenotype1.96589682
25MP0001790_abnormal_immune_system1.96589682
26MP0005409_darkened_coat_color1.95690279
27MP0002163_abnormal_gland_morphology1.94606115
28MP0004084_abnormal_cardiac_muscle1.91141084
29MP0005275_abnormal_skin_tensile1.90980429
30MP0004233_abnormal_muscle_weight1.89858118
31MP0008877_abnormal_DNA_methylation1.89032457
32MP0005379_endocrine/exocrine_gland_phen1.88081699
33MP0002277_abnormal_respiratory_mucosa1.85953356
34MP0002009_preneoplasia1.79064214
35MP0003941_abnormal_skin_development1.78045191
36MP0000383_abnormal_hair_follicle1.75990491
37MP0001800_abnormal_humoral_immune1.71176180
38MP0002148_abnormal_hypersensitivity_rea1.69563739
39MP0004957_abnormal_blastocyst_morpholog1.64274007
40MP0005000_abnormal_immune_tolerance1.64069431
41MP0005174_abnormal_tail_pigmentation1.61372562
42MP0003221_abnormal_cardiomyocyte_apopto1.58789996
43MP0000372_irregular_coat_pigmentation1.58388507
44MP0010307_abnormal_tumor_latency1.57932631
45MP0005076_abnormal_cell_differentiation1.55201584
46MP0003950_abnormal_plasma_membrane1.54480898
47MP0005451_abnormal_body_composition1.53658170
48MP0002452_abnormal_antigen_presenting1.51742078
49MP0003646_muscle_fatigue1.50699100
50MP0004036_abnormal_muscle_relaxation1.49251323
51MP0003890_abnormal_embryonic-extraembry1.46706671
52MP0005645_abnormal_hypothalamus_physiol1.46151408
53MP0002723_abnormal_immune_serum1.44498791
54MP0009785_altered_susceptibility_to1.42749541
55MP0000569_abnormal_digit_pigmentation1.42718099
56MP0003656_abnormal_erythrocyte_physiolo1.39786702
57MP0004808_abnormal_hematopoietic_stem1.36329016
58MP0002420_abnormal_adaptive_immunity1.35317065
59MP0001819_abnormal_immune_cell1.34959941
60MP0002396_abnormal_hematopoietic_system1.33277243
61MP0005623_abnormal_meninges_morphology1.32509027
62MP0001986_abnormal_taste_sensitivity1.31804934
63MP0002269_muscular_atrophy1.30558001
64MP0001661_extended_life_span1.30051783
65MP0002060_abnormal_skin_morphology1.28967372
66MP0003191_abnormal_cellular_cholesterol1.28385490
67MP0003077_abnormal_cell_cycle1.27148403
68MP0003693_abnormal_embryo_hatching1.26945003
69MP0003724_increased_susceptibility_to1.25394889
70MP0003984_embryonic_growth_retardation1.23963605
71MP0004742_abnormal_vestibular_system1.23888508
72MP0000749_muscle_degeneration1.23215815
73MP0002095_abnormal_skin_pigmentation1.22408788
74MP0002419_abnormal_innate_immunity1.21275179
75MP0004264_abnormal_extraembryonic_tissu1.20933266
76MP0002796_impaired_skin_barrier1.20675838
77MP0002088_abnormal_embryonic_growth/wei1.20170533
78MP0005025_abnormal_response_to1.19106219
79MP0002006_tumorigenesis1.19046048
80MP0004185_abnormal_adipocyte_glucose1.18110383
81MP0009333_abnormal_splenocyte_physiolog1.18025525
82MP0000613_abnormal_salivary_gland1.16732515
83MP0002332_abnormal_exercise_endurance1.16676272
84MP0006082_CNS_inflammation1.16227038
85MP0003828_pulmonary_edema1.15476061
86MP0000371_diluted_coat_color1.13927319
87MP0001697_abnormal_embryo_size1.11373106
88MP0001216_abnormal_epidermal_layer1.11072841
89MP0010094_abnormal_chromosome_stability1.10638516
90MP0004087_abnormal_muscle_fiber1.09170731
91MP0003183_abnormal_peptide_metabolism1.08335495
92MP0002405_respiratory_system_inflammati1.08212485
93MP0000350_abnormal_cell_proliferation1.07535405
94MP0000685_abnormal_immune_system1.07115092
95MP0008260_abnormal_autophagy1.06985108
96MP0000579_abnormal_nail_morphology1.06691197
97MP0001672_abnormal_embryogenesis/_devel1.06357193
98MP0005380_embryogenesis_phenotype1.06357193
99MP0002086_abnormal_extraembryonic_tissu1.06150646
100MP0009384_cardiac_valve_regurgitation1.05182096
101MP0002398_abnormal_bone_marrow1.04735138
102MP0003121_genomic_imprinting1.03944500
103MP0001730_embryonic_growth_arrest1.03936576
104MP0004197_abnormal_fetal_growth/weight/1.02278434
105MP0005646_abnormal_pituitary_gland1.01626709
106MP0005501_abnormal_skin_physiology1.01378489
107MP0000716_abnormal_immune_system1.01265155
108MP0005408_hypopigmentation1.01150212
109MP0000759_abnormal_skeletal_muscle1.01128809
110MP0000733_abnormal_muscle_development1.00461433
111MP0003091_abnormal_cell_migration1.00451533
112MP0003937_abnormal_limbs/digits/tail_de0.99847302
113MP0003938_abnormal_ear_development0.97428662
114MP0000377_abnormal_hair_follicle0.96931810
115MP0008007_abnormal_cellular_replicative0.96353824
116MP0003300_gastrointestinal_ulcer0.96014229
117MP0001346_abnormal_lacrimal_gland0.95656071
118MP0005621_abnormal_cell_physiology0.94764846
119MP0005551_abnormal_eye_electrophysiolog0.94571655
120MP0001191_abnormal_skin_condition0.93636940
121MP0000750_abnormal_muscle_regeneration0.92830880
122MP0005075_abnormal_melanosome_morpholog0.92581346
123MP0001873_stomach_inflammation0.91875775
124MP0010678_abnormal_skin_adnexa0.91101452
125MP0000026_abnormal_inner_ear0.90834571
126MP0003045_fibrosis0.90276337
127MP0000920_abnormal_myelination0.90154344
128MP0001486_abnormal_startle_reflex0.90146028
129MP0002933_joint_inflammation0.89510617
130MP0000703_abnormal_thymus_morphology0.88703551
131MP0002098_abnormal_vibrissa_morphology0.88244538
132MP0000627_abnormal_mammary_gland0.87358567
133MP0002084_abnormal_developmental_patter0.87194975
134MP0000358_abnormal_cell_content/0.86740974
135MP0004134_abnormal_chest_morphology0.86209866
136MP0002166_altered_tumor_susceptibility0.85472229
137MP0005310_abnormal_salivary_gland0.83970934
138MP0005023_abnormal_wound_healing0.82557141
139MP0005384_cellular_phenotype0.82093521
140MP0001186_pigmentation_phenotype0.81887853
141MP0005220_abnormal_exocrine_pancreas0.81478841
142MP0001915_intracranial_hemorrhage0.80504926
143MP0002928_abnormal_bile_duct0.80387961
144MP0002080_prenatal_lethality0.78660709
145MP0000689_abnormal_spleen_morphology0.78563281
146MP0003453_abnormal_keratinocyte_physiol0.77737688
147MP0000470_abnormal_stomach_morphology0.77688151
148MP0003436_decreased_susceptibility_to0.77521228
149MP0004130_abnormal_muscle_cell0.76969598
150MP0002106_abnormal_muscle_physiology0.76673135
151MP0002177_abnormal_outer_ear0.76618935
152MP0002938_white_spotting0.76028483
153MP0003111_abnormal_nucleus_morphology0.75369261
154MP0008932_abnormal_embryonic_tissue0.75285275
155MP0010630_abnormal_cardiac_muscle0.74986520
156MP0002896_abnormal_bone_mineralization0.74598736
157MP0002722_abnormal_immune_system0.74515674
158MP0008995_early_reproductive_senescence0.74465112
159MP0001286_abnormal_eye_development0.74272436
160MP0003868_abnormal_feces_composition0.74245209
161MP0002168_other_aberrant_phenotype0.73869899
162MP0005253_abnormal_eye_physiology0.73521106
163MP0001853_heart_inflammation0.72596017
164MP0002998_abnormal_bone_remodeling0.70208806
165MP0003786_premature_aging0.69132864
166MP0002638_abnormal_pupillary_reflex0.68728032
167MP0001963_abnormal_hearing_physiology0.67840646
168MP0006072_abnormal_retinal_apoptosis0.67191946
169MP0002429_abnormal_blood_cell0.65401208
170MP0000647_abnormal_sebaceous_gland0.63599896
171MP0001851_eye_inflammation0.62263444
172MP0002075_abnormal_coat/hair_pigmentati0.60790358
173MP0000778_abnormal_nervous_system0.60743851
174MP0000631_abnormal_neuroendocrine_gland0.59971859
175MP0000432_abnormal_head_morphology0.59945635
176MP0010155_abnormal_intestine_physiology0.59603227

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.51639825
2Chromsome breakage (HP:0040012)5.11020983
3Syringomyelia (HP:0003396)4.02796085
4Spinal cord lesions (HP:0100561)4.02796085
5Curly hair (HP:0002212)3.98998400
6Asymmetry of the thorax (HP:0001555)3.65532990
7Duplicated collecting system (HP:0000081)3.65217791
8Prostate neoplasm (HP:0100787)3.64411445
9Absent frontal sinuses (HP:0002688)3.44012356
10Nemaline bodies (HP:0003798)3.39467294
11Entropion (HP:0000621)3.30064782
12Abnormality of the renal collecting system (HP:0004742)3.27338917
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.20343151
14Muscle fiber inclusion bodies (HP:0100299)3.14587390
15Cutaneous melanoma (HP:0012056)3.12441715
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.09066068
17Absent/shortened dynein arms (HP:0200106)3.09066068
18Papillary thyroid carcinoma (HP:0002895)2.90665280
19Ectopic kidney (HP:0000086)2.87916906
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.86206424
21Abnormality of the nasal septum (HP:0000419)2.84546863
22Septo-optic dysplasia (HP:0100842)2.79875361
23Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.79191471
24Deep philtrum (HP:0002002)2.76773329
25Aplasia cutis congenita (HP:0001057)2.74070403
26Lip pit (HP:0100267)2.66418727
27Abnormality of the prostate (HP:0008775)2.65393292
28Thyroid carcinoma (HP:0002890)2.65000714
29Cystic hygroma (HP:0000476)2.60973989
30Abnormality of incisor morphology (HP:0011063)2.60234712
31Abnormality of the frontal sinuses (HP:0002687)2.55575502
32White forelock (HP:0002211)2.54883093
33Septate vagina (HP:0001153)2.54374860
34Bladder neoplasm (HP:0009725)2.51149159
35Bladder carcinoma (HP:0002862)2.51149159
36Optic neuritis (HP:0100653)2.50285230
37Retrobulbar optic neuritis (HP:0100654)2.50285230
38Submucous cleft hard palate (HP:0000176)2.47283164
39Abnormal ciliary motility (HP:0012262)2.46744194
40Abnormality of chromosome stability (HP:0003220)2.45836722
41Abnormality of T cell number (HP:0011839)2.44479410
42Duplication of thumb phalanx (HP:0009942)2.42833002
43T lymphocytopenia (HP:0005403)2.42814457
44Transitional cell carcinoma of the bladder (HP:0006740)2.41833825
45Abnormal hair whorl (HP:0010721)2.40030749
46Stomach cancer (HP:0012126)2.39991639
47Upper limb muscle weakness (HP:0003484)2.39172150
48Clubbing of toes (HP:0100760)2.36699923
49Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.35768406
50Recurrent abscess formation (HP:0002722)2.35601757
51Abnormality of DNA repair (HP:0003254)2.35094529
52Congenital stationary night blindness (HP:0007642)2.33706645
53Abnormality of the preputium (HP:0100587)2.32496699
54Patchy hypopigmentation of hair (HP:0011365)2.31394283
55Chronic diarrhea (HP:0002028)2.31138770
56Microglossia (HP:0000171)2.29134281
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.28549624
58Progressive muscle weakness (HP:0003323)2.24163744
59Poikiloderma (HP:0001029)2.22259412
60Fatigue (HP:0012378)2.21107808
61Abnormal respiratory epithelium morphology (HP:0012253)2.21000719
62Abnormal respiratory motile cilium morphology (HP:0005938)2.21000719
63Obstructive lung disease (HP:0006536)2.20312585
64Chronic obstructive pulmonary disease (HP:0006510)2.20312585
65Thyroiditis (HP:0100646)2.18283183
66Muscle hypertrophy of the lower extremities (HP:0008968)2.18116943
67Abnormality of the columella (HP:0009929)2.17972387
68Pelvic girdle muscle weakness (HP:0003749)2.17116865
69Ridged nail (HP:0001807)2.16506468
70Selective tooth agenesis (HP:0001592)2.15751105
71Breast carcinoma (HP:0003002)2.13947007
72Short chin (HP:0000331)2.13245692
73Abnormality of homocysteine metabolism (HP:0010919)2.12324632
74Homocystinuria (HP:0002156)2.12324632
75Spondylolisthesis (HP:0003302)2.10944361
76Meckel diverticulum (HP:0002245)2.09961498
77Thin bony cortex (HP:0002753)2.09845604
78Leiomyosarcoma (HP:0100243)2.09739105
79Uterine leiomyosarcoma (HP:0002891)2.09739105
80Gastrointestinal carcinoma (HP:0002672)2.08537580
81Malignant gastrointestinal tract tumors (HP:0006749)2.08537580
82Mediastinal lymphadenopathy (HP:0100721)2.06987099
83Onycholysis (HP:0001806)2.06057438
84Abnormality of the incisor (HP:0000676)2.05981624
85Absent septum pellucidum (HP:0001331)2.05240441
86Subacute progressive viral hepatitis (HP:0006572)2.05222202
87Recurrent pneumonia (HP:0006532)2.05026726
88Nephroblastoma (Wilms tumor) (HP:0002667)2.04669597
89Abnormality of the fingertips (HP:0001211)2.01941412
90Mitral stenosis (HP:0001718)2.01384066
91Abnormality of nail color (HP:0100643)2.01366671
92Tubulointerstitial nephritis (HP:0001970)2.00644915
93Chronic mucocutaneous candidiasis (HP:0002728)2.00483556
94Recurrent cutaneous fungal infections (HP:0011370)2.00483556
95Parakeratosis (HP:0001036)2.00144468
96Osteolytic defects of the hand bones (HP:0009699)1.99801823
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.99801823
98Severe combined immunodeficiency (HP:0004430)1.99006801
99Abnormal respiratory motile cilium physiology (HP:0012261)1.98598466
100Nasolacrimal duct obstruction (HP:0000579)1.97699737
101Round ear (HP:0100830)1.97593984
102Abnormality of the hip-girdle musculature (HP:0001445)1.96984699
103Abnormality of the musculature of the pelvis (HP:0001469)1.96984699
104Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.96328025
105Abnormality of the ileum (HP:0001549)1.95506146
106Stomatitis (HP:0010280)1.95076714
107Volvulus (HP:0002580)1.95027224
108Recurrent sinusitis (HP:0011108)1.93244177
109Embryonal renal neoplasm (HP:0011794)1.92222517
110Conical tooth (HP:0000698)1.92001757
111Abnormality of the septum pellucidum (HP:0007375)1.91866855
112Abnormal foot bone ossification (HP:0010675)1.91740267
113Acute myeloid leukemia (HP:0004808)1.91319655
114Meningitis (HP:0001287)1.90109542
115Optic nerve hypoplasia (HP:0000609)1.89730477
116Coarse hair (HP:0002208)1.88072476
117Broad ribs (HP:0000885)1.87414550
118Freckling (HP:0001480)1.87364859
119Arterial tortuosity (HP:0005116)1.85920037
120Thick nail (HP:0001805)1.85284184
121Attenuation of retinal blood vessels (HP:0007843)1.85123217
122Sandal gap (HP:0001852)1.84043889
123Alveolar cell carcinoma (HP:0006519)1.84024676
124Sparse lateral eyebrow (HP:0005338)1.83703336
125Febrile seizures (HP:0002373)1.81389628
126Cupped ear (HP:0000378)1.80895378
127Type 1 muscle fiber predominance (HP:0003803)1.80841820
128Calf muscle hypertrophy (HP:0008981)1.80721807
129IgG deficiency (HP:0004315)1.80414492
130Rhabdomyosarcoma (HP:0002859)1.80292358
131Preaxial hand polydactyly (HP:0001177)1.80069869
132Ulnar deviation of the wrist (HP:0003049)1.79589480
133Neoplasm of the tracheobronchial system (HP:0100552)1.79350309
134Progressive external ophthalmoplegia (HP:0000590)1.78565899
135Congenital sensorineural hearing impairment (HP:0008527)1.77977823
136Thickened calvaria (HP:0002684)1.76967641
137J-shaped sella turcica (HP:0002680)1.76064477
138Recurrent fungal infections (HP:0002841)1.75769686
139Anhidrosis (HP:0000970)1.75403304
140Insidious onset (HP:0003587)1.75197998
141Termporal pattern (HP:0011008)1.75197998
142Prominent nose (HP:0000448)1.74682041
143Eczematoid dermatitis (HP:0000976)1.73521389
144Abnormality of the renal medulla (HP:0100957)1.73125130
145Agammaglobulinemia (HP:0004432)1.73054388
146Renal cortical cysts (HP:0000803)1.71946839
147Abnormality of eosinophils (HP:0001879)1.71900605
148Pulmonary artery stenosis (HP:0004415)1.71823056
149Cerebellar dysplasia (HP:0007033)1.70636794
150Micronodular cirrhosis (HP:0001413)1.69978816
151Vasculitis (HP:0002633)1.69385126
152Ankyloglossia (HP:0010296)1.68924996
153Atrophic scars (HP:0001075)1.68611963
154Decreased central vision (HP:0007663)1.68260924
155Hypoplasia of the pons (HP:0012110)1.67604186
156Ectropion (HP:0000656)1.67147352
157Shoulder girdle muscle weakness (HP:0003547)1.66869210
158Hyporeflexia of lower limbs (HP:0002600)1.66807363
159Relative macrocephaly (HP:0004482)1.66657980
160Abnormality of the lacrimal duct (HP:0011481)1.65945469
161Biliary tract neoplasm (HP:0100574)1.65903204
162Eosinophilia (HP:0001880)1.65194590
163Nephronophthisis (HP:0000090)1.64881062
164Abnormality of male internal genitalia (HP:0000022)1.64376577
165Coxa valga (HP:0002673)1.64259515
166Delayed closure of the anterior fontanelle (HP:0001476)1.63184337
167Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62802950
168Abnormal delayed hypersensitivity skin test (HP:0002963)1.62223545
169Increased IgM level (HP:0003496)1.61829278
170Difficulty running (HP:0009046)1.60263713
171Absent rod-and cone-mediated responses on ERG (HP:0007688)1.60206443
172Recurrent bacterial skin infections (HP:0005406)1.60039111
173Encephalitis (HP:0002383)1.59529682
174IgM deficiency (HP:0002850)1.58883950
175Orchitis (HP:0100796)1.58684924
176Abnormality of the nasolacrimal system (HP:0000614)1.58462838
177Abnormality of secondary sexual hair (HP:0009888)1.58252398
178Abnormality of the axillary hair (HP:0100134)1.58252398
179Vascular tortuosity (HP:0004948)1.58028004
180Abnormality of the pons (HP:0007361)1.57965175
181Uterine neoplasm (HP:0010784)1.57770161
182Dysmetric saccades (HP:0000641)1.55926172
183Melanoma (HP:0002861)1.55179067
184Difficulty climbing stairs (HP:0003551)1.55147877
185Fair hair (HP:0002286)1.52293258
186Rimmed vacuoles (HP:0003805)1.51425236
187Narrow palate (HP:0000189)1.50961741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.20216408
2CASK3.80806312
3EIF2AK33.70302194
4EIF2AK13.42125535
5TXK3.29914379
6MAP3K143.17134334
7INSRR2.78826000
8MKNK22.65065361
9NUAK12.43543277
10TTN2.43204765
11BLK2.36462031
12ZAK2.15670152
13IRAK42.03203620
14EIF2AK22.01352978
15OBSCN1.93531337
16TNIK1.92650154
17MKNK11.90937461
18RPS6KB21.86550006
19BRSK21.83925984
20TEC1.83224684
21PIK3CG1.81241715
22IRAK31.80220415
23GRK11.78080770
24NEK91.70727573
25NEK61.64424850
26YES11.62200554
27TRIM281.56885492
28ITK1.56765673
29RPS6KA41.55701588
30PKN11.47973536
31BMPR1B1.46466616
32PRPF4B1.45512787
33IKBKB1.42651554
34BMPR21.41202482
35MST41.36131996
36NEK11.32672723
37IKBKE1.31364657
38SRPK11.28788350
39STK161.23613723
40CDK61.21586733
41IRAK21.20950314
42BRD41.20261109
43SIK31.20116757
44JAK31.19399589
45MAP3K101.16923864
46IRAK11.12777903
47CHUK1.09039687
48CLK11.08016983
49FRK1.05936951
50NLK1.05459551
51PBK1.03891466
52CDK31.02284325
53GRK70.97898872
54MAPK130.97868999
55MAP2K70.97567676
56CDK120.94247647
57PKN20.94142990
58TNK20.92467245
59MAP4K10.91944314
60TRPM70.91755885
61CDC70.90914642
62JAK10.90415477
63CAMK1G0.90110189
64LCK0.89598544
65SGK30.86224438
66PDGFRA0.86084200
67TAOK30.86055797
68PNCK0.84456765
69PLK40.82143774
70PRKCQ0.78841595
71STK240.78556255
72SIK10.78412974
73PDGFRB0.78252649
74BCR0.77950444
75TSSK60.77433084
76MAP3K130.76538337
77SGK20.76301985
78MAP3K20.76058117
79TRIB30.76002440
80RIPK40.75097956
81BTK0.74215561
82PIK3CA0.74123858
83MAP3K120.70354440
84LYN0.69571870
85TYK20.68762528
86HCK0.68273055
87ATR0.67554851
88ACVR1B0.67220731
89ADRBK20.66980312
90MAPK70.66442657
91STK38L0.64948780
92VRK10.64727745
93STK40.63604876
94STK390.61618542
95WNK10.61416395
96CHEK20.61099469
97PIM10.59225319
98TGFBR10.57721088
99ERBB30.57565952
100CDK90.56843328
101DMPK0.56801609
102EEF2K0.56249084
103STK30.55957937
104CSK0.55708624
105CSNK1A1L0.55422700
106CAMK1D0.55285133
107PAK20.53605308
108PLK30.53394852
109MET0.51687687
110OXSR10.50100069
111TAF10.49990627
112RPS6KA50.49751661
113ATM0.49717753
114CHEK10.49321797
115MAP2K30.48539315
116KSR10.48538839
117PRKCE0.48450004
118MARK30.48402880
119MUSK0.47886906
120AURKB0.46047533
121MELK0.45942575
122ERBB40.45259161
123FGFR20.45106395
124FGFR30.44865884
125LATS10.44174519
126TTK0.44127923
127SGK10.44106449
128AKT30.43918686
129EGFR0.43218847
130EPHB10.42755392
131PAK30.42452485
132MTOR0.41664070
133IGF1R0.41344218
134LIMK10.40868513
135PLK10.40059164
136PRKG10.39616231
137SIK20.39291584
138STK100.37880774
139PAK40.37555298
140MAPK150.36850619
141SYK0.36612667
142CAMKK20.36244492
143RPS6KB10.36189874
144SGK2230.35807949
145SGK4940.35807949
146PLK20.35668831
147ABL10.35154149
148CDK40.35096462
149RAF10.31221169
150FGFR10.29934710
151FGR0.28878355
152CSF1R0.28092745

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.06695053
2Allograft rejection_Homo sapiens_hsa053302.89496258
3Autoimmune thyroid disease_Homo sapiens_hsa053202.59141291
4Fanconi anemia pathway_Homo sapiens_hsa034602.58915707
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.45099084
6Selenocompound metabolism_Homo sapiens_hsa004502.23374743
7Primary immunodeficiency_Homo sapiens_hsa053402.20224195
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.14781980
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01528098
10Phototransduction_Homo sapiens_hsa047441.96594615
11Non-small cell lung cancer_Homo sapiens_hsa052231.93584517
12Chronic myeloid leukemia_Homo sapiens_hsa052201.89227780
13Small cell lung cancer_Homo sapiens_hsa052221.82283846
14Pancreatic cancer_Homo sapiens_hsa052121.78479049
15Non-homologous end-joining_Homo sapiens_hsa034501.78113126
16Homologous recombination_Homo sapiens_hsa034401.76941855
17mTOR signaling pathway_Homo sapiens_hsa041501.76809242
18Measles_Homo sapiens_hsa051621.75216659
19Acute myeloid leukemia_Homo sapiens_hsa052211.72722960
20Thyroid cancer_Homo sapiens_hsa052161.71999256
21Endometrial cancer_Homo sapiens_hsa052131.69722449
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69300683
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.63991899
24Hematopoietic cell lineage_Homo sapiens_hsa046401.56323313
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52385217
26Renal cell carcinoma_Homo sapiens_hsa052111.50606836
27Type I diabetes mellitus_Homo sapiens_hsa049401.47857167
28Proteoglycans in cancer_Homo sapiens_hsa052051.47256301
29T cell receptor signaling pathway_Homo sapiens_hsa046601.44644912
30Melanoma_Homo sapiens_hsa052181.43080766
31Prolactin signaling pathway_Homo sapiens_hsa049171.42823027
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42819132
33RNA transport_Homo sapiens_hsa030131.42731091
34Glioma_Homo sapiens_hsa052141.39006262
35Rheumatoid arthritis_Homo sapiens_hsa053231.36582623
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35758024
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34226835
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32040987
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31666147
40Bladder cancer_Homo sapiens_hsa052191.30957655
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30029620
42Insulin resistance_Homo sapiens_hsa049311.28335052
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28023422
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.27845327
45Inositol phosphate metabolism_Homo sapiens_hsa005621.26168325
46TGF-beta signaling pathway_Homo sapiens_hsa043501.24855218
47Sphingolipid metabolism_Homo sapiens_hsa006001.23587691
48Focal adhesion_Homo sapiens_hsa045101.22594268
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20585498
50Leishmaniasis_Homo sapiens_hsa051401.20061967
51ErbB signaling pathway_Homo sapiens_hsa040121.18969550
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16848987
53Asthma_Homo sapiens_hsa053101.16188916
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12669680
55Nicotine addiction_Homo sapiens_hsa050331.12165468
56Basal transcription factors_Homo sapiens_hsa030221.11974943
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11155976
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11059542
59Base excision repair_Homo sapiens_hsa034101.09054331
60Malaria_Homo sapiens_hsa051441.08774755
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08674317
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08390729
63Herpes simplex infection_Homo sapiens_hsa051681.08266194
64Jak-STAT signaling pathway_Homo sapiens_hsa046301.08254312
65Central carbon metabolism in cancer_Homo sapiens_hsa052301.07036268
66Insulin signaling pathway_Homo sapiens_hsa049101.06535665
67Platelet activation_Homo sapiens_hsa046111.05601037
68Osteoclast differentiation_Homo sapiens_hsa043801.03939297
69Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03813833
70Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03501227
71Colorectal cancer_Homo sapiens_hsa052101.02959991
72Viral myocarditis_Homo sapiens_hsa054161.00472610
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97098258
74Choline metabolism in cancer_Homo sapiens_hsa052310.96933860
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94467330
76Chemokine signaling pathway_Homo sapiens_hsa040620.91848129
77Protein export_Homo sapiens_hsa030600.90867583
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88507184
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88435993
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.86548650
81Dorso-ventral axis formation_Homo sapiens_hsa043200.85850135
82Influenza A_Homo sapiens_hsa051640.84146575
83Ether lipid metabolism_Homo sapiens_hsa005650.84146463
84Regulation of autophagy_Homo sapiens_hsa041400.83713204
85mRNA surveillance pathway_Homo sapiens_hsa030150.83261236
86Systemic lupus erythematosus_Homo sapiens_hsa053220.83089695
87TNF signaling pathway_Homo sapiens_hsa046680.82135291
88Hippo signaling pathway_Homo sapiens_hsa043900.79273384
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79013794
90B cell receptor signaling pathway_Homo sapiens_hsa046620.78839159
91DNA replication_Homo sapiens_hsa030300.78732082
92Mismatch repair_Homo sapiens_hsa034300.77842233
93Nucleotide excision repair_Homo sapiens_hsa034200.75182027
94Serotonergic synapse_Homo sapiens_hsa047260.75021885
95RNA degradation_Homo sapiens_hsa030180.73444614
96VEGF signaling pathway_Homo sapiens_hsa043700.73353421
97Vitamin digestion and absorption_Homo sapiens_hsa049770.73029914
98PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71835054
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71802912
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71729629
101Morphine addiction_Homo sapiens_hsa050320.71679970
102Axon guidance_Homo sapiens_hsa043600.70805041
103AMPK signaling pathway_Homo sapiens_hsa041520.70761531
104Sulfur metabolism_Homo sapiens_hsa009200.69496947
105RNA polymerase_Homo sapiens_hsa030200.69008906
106Taste transduction_Homo sapiens_hsa047420.68806353
107African trypanosomiasis_Homo sapiens_hsa051430.68507176
108Arachidonic acid metabolism_Homo sapiens_hsa005900.68167313
109Spliceosome_Homo sapiens_hsa030400.68116014
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67408427
111p53 signaling pathway_Homo sapiens_hsa041150.67318111
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67243122
113Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66347477
114Staphylococcus aureus infection_Homo sapiens_hsa051500.65354327
115Antigen processing and presentation_Homo sapiens_hsa046120.64452066
116Shigellosis_Homo sapiens_hsa051310.63924754
117Amoebiasis_Homo sapiens_hsa051460.63675120
118Type II diabetes mellitus_Homo sapiens_hsa049300.63578825
119Lysine degradation_Homo sapiens_hsa003100.63064423
120Toxoplasmosis_Homo sapiens_hsa051450.63036324
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62511611
122HIF-1 signaling pathway_Homo sapiens_hsa040660.60884648
123Pertussis_Homo sapiens_hsa051330.60687362
124Tuberculosis_Homo sapiens_hsa051520.60406065
125MicroRNAs in cancer_Homo sapiens_hsa052060.60305479
126Tight junction_Homo sapiens_hsa045300.59796326
127One carbon pool by folate_Homo sapiens_hsa006700.58333910
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55152036
129Ras signaling pathway_Homo sapiens_hsa040140.54405492
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54126813
131Hepatitis B_Homo sapiens_hsa051610.53709346
132Epstein-Barr virus infection_Homo sapiens_hsa051690.53169222
133HTLV-I infection_Homo sapiens_hsa051660.53060155
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52568340
135Hepatitis C_Homo sapiens_hsa051600.52542631
136Prostate cancer_Homo sapiens_hsa052150.51840918
137Apoptosis_Homo sapiens_hsa042100.51813180
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50945371
139Salmonella infection_Homo sapiens_hsa051320.50321302
140Wnt signaling pathway_Homo sapiens_hsa043100.49380612
141Notch signaling pathway_Homo sapiens_hsa043300.47656512
142Legionellosis_Homo sapiens_hsa051340.47530513
143MAPK signaling pathway_Homo sapiens_hsa040100.47107825
144Glutamatergic synapse_Homo sapiens_hsa047240.46517640
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45662349
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45128807
147Viral carcinogenesis_Homo sapiens_hsa052030.44897794
148Cell cycle_Homo sapiens_hsa041100.44539060
149Calcium signaling pathway_Homo sapiens_hsa040200.43604580
150Ovarian steroidogenesis_Homo sapiens_hsa049130.42213367
151Pathways in cancer_Homo sapiens_hsa052000.41790623
152Circadian rhythm_Homo sapiens_hsa047100.41785562
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41317057
154FoxO signaling pathway_Homo sapiens_hsa040680.40498259
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.40486769
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40289390
157Adherens junction_Homo sapiens_hsa045200.39638231
158Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38880915
159Phagosome_Homo sapiens_hsa041450.36962745
160Steroid biosynthesis_Homo sapiens_hsa001000.36416267
161ECM-receptor interaction_Homo sapiens_hsa045120.35290968
162Linoleic acid metabolism_Homo sapiens_hsa005910.34556607

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