AP3M2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.88528512
2synaptic vesicle exocytosis (GO:0016079)5.72623990
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.47168558
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.41817652
5vocalization behavior (GO:0071625)5.39677751
6glutamate secretion (GO:0014047)5.36017138
7regulation of synaptic vesicle exocytosis (GO:2000300)5.21294517
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.16206197
9synaptic vesicle maturation (GO:0016188)5.13676928
10protein localization to synapse (GO:0035418)5.09910679
11neuron cell-cell adhesion (GO:0007158)5.05917499
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04790602
13locomotory exploration behavior (GO:0035641)5.02141915
14regulation of glutamate receptor signaling pathway (GO:1900449)4.89820092
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.68893206
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.59106114
17regulation of synaptic vesicle transport (GO:1902803)4.58982305
18presynaptic membrane assembly (GO:0097105)4.44688452
19neuronal action potential propagation (GO:0019227)4.40816223
20neurotransmitter-gated ion channel clustering (GO:0072578)4.34628634
21neurotransmitter secretion (GO:0007269)4.34087180
22synaptic transmission, glutamatergic (GO:0035249)4.25826869
23presynaptic membrane organization (GO:0097090)4.22148428
24glutamate receptor signaling pathway (GO:0007215)4.21379264
25neuron-neuron synaptic transmission (GO:0007270)4.14723308
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07719258
27exploration behavior (GO:0035640)4.05409656
28regulation of neuronal synaptic plasticity (GO:0048168)4.01307187
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.00219205
30postsynaptic membrane organization (GO:0001941)3.97016287
31negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93683787
32gamma-aminobutyric acid transport (GO:0015812)3.93298390
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.93171950
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88807328
35histone H2A acetylation (GO:0043968)3.88231746
36synapsis (GO:0007129)3.88181636
37regulation of synapse structural plasticity (GO:0051823)3.79882327
38long-term memory (GO:0007616)3.79762932
39layer formation in cerebral cortex (GO:0021819)3.75982344
40regulation of postsynaptic membrane potential (GO:0060078)3.74956471
41synaptic vesicle endocytosis (GO:0048488)3.73355631
42long-term synaptic potentiation (GO:0060291)3.72668720
43positive regulation of membrane potential (GO:0045838)3.72607085
44positive regulation of synapse maturation (GO:0090129)3.71639025
45proline transport (GO:0015824)3.67544537
46resolution of meiotic recombination intermediates (GO:0000712)3.63042282
47neurotransmitter transport (GO:0006836)3.62333171
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.58738760
49somatic diversification of immune receptors via somatic mutation (GO:0002566)3.58738760
50response to histamine (GO:0034776)3.57667490
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.56025873
52regulation of neurotransmitter secretion (GO:0046928)3.56021925
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50935821
54regulation of meiosis I (GO:0060631)3.50818627
55neuron recognition (GO:0008038)3.50800969
56regulation of synaptic plasticity (GO:0048167)3.49053365
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.48650349
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.43913692
59dendritic spine morphogenesis (GO:0060997)3.43584109
60cerebellar granule cell differentiation (GO:0021707)3.42424837
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35617411
62cerebellar Purkinje cell differentiation (GO:0021702)3.35156552
63regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.34904507
64negative regulation of DNA recombination (GO:0045910)3.34469767
65transmission of nerve impulse (GO:0019226)3.33788616
66auditory behavior (GO:0031223)3.33317984
67negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32676043
68response to auditory stimulus (GO:0010996)3.31506017
69regulation of vesicle fusion (GO:0031338)3.31409151
70positive regulation of neurotransmitter secretion (GO:0001956)3.30902979
71cellular potassium ion homeostasis (GO:0030007)3.30221415
72regulation of neurotransmitter levels (GO:0001505)3.29242358
73regulation of neurotransmitter transport (GO:0051588)3.26390568
74membrane hyperpolarization (GO:0060081)3.25510636
75positive regulation of neurotransmitter transport (GO:0051590)3.24876994
76positive regulation of meiosis (GO:0045836)3.24472312
77activation of protein kinase A activity (GO:0034199)3.22547100
78regulation of dendritic spine morphogenesis (GO:0061001)3.21568658
79axonal fasciculation (GO:0007413)3.16117503
80startle response (GO:0001964)3.15751901
81membrane depolarization (GO:0051899)3.14249803
82positive regulation of synaptic transmission (GO:0050806)3.12214093
83meiotic chromosome segregation (GO:0045132)3.10014388
84innervation (GO:0060384)3.07732305
85positive regulation of synapse assembly (GO:0051965)3.05960637
86behavioral response to cocaine (GO:0048148)3.05855476
87synapse assembly (GO:0007416)3.04348333
88regulation of glutamate secretion (GO:0014048)3.03241915
89mechanosensory behavior (GO:0007638)3.02894452
90regulation of synaptic transmission, GABAergic (GO:0032228)3.00780070
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00605695
92behavioral defense response (GO:0002209)3.00082721
93behavioral fear response (GO:0001662)3.00082721
94regulation of synaptic transmission (GO:0050804)3.00045190
95learning (GO:0007612)2.99056212
96pyrimidine nucleobase catabolic process (GO:0006208)2.98357954
97regulation of synapse maturation (GO:0090128)2.97494558
98regulation of voltage-gated calcium channel activity (GO:1901385)2.97423307
99synaptic transmission (GO:0007268)2.97208978
100metaphase plate congression (GO:0051310)2.94441558
101regulation of respiratory system process (GO:0044065)2.93573783
102positive regulation of meiotic cell cycle (GO:0051446)2.92151756
103regulation of dendritic spine development (GO:0060998)2.91565592
104neuromuscular process controlling posture (GO:0050884)2.91222638
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.91115561
106piRNA metabolic process (GO:0034587)2.90566641
107fear response (GO:0042596)2.90126146
108regulation of female receptivity (GO:0045924)2.88918707
109* establishment of synaptic vesicle localization (GO:0097480)2.88853820
110* synaptic vesicle transport (GO:0048489)2.88853820
111neuromuscular process controlling balance (GO:0050885)2.88383318
112dendrite morphogenesis (GO:0048813)2.87001398
113prepulse inhibition (GO:0060134)2.86912170
114membrane depolarization during action potential (GO:0086010)2.86703872
115regulation of DNA endoreduplication (GO:0032875)2.71718107
116chromosome organization involved in meiosis (GO:0070192)2.70185645
117cerebral cortex radially oriented cell migration (GO:0021799)2.68745380
118DNA double-strand break processing (GO:0000729)2.66479646
119intra-S DNA damage checkpoint (GO:0031573)2.66272183
120mitotic sister chromatid cohesion (GO:0007064)2.62452113
121establishment of mitochondrion localization (GO:0051654)2.59822893
122intraciliary transport (GO:0042073)2.57861815
123negative regulation of dendrite morphogenesis (GO:0050774)2.56926028
124mitotic metaphase plate congression (GO:0007080)2.53451492
125retinal cone cell development (GO:0046549)2.51353748
126central nervous system projection neuron axonogenesis (GO:0021952)2.49842777
127kinetochore organization (GO:0051383)2.49179004
128negative regulation of dendrite development (GO:2000171)2.47546205
129mitotic sister chromatid segregation (GO:0000070)2.47051737
130cullin deneddylation (GO:0010388)2.46142023
131sister chromatid cohesion (GO:0007062)2.45719299
132nucleobase catabolic process (GO:0046113)2.43533784
133regulation of double-strand break repair via homologous recombination (GO:0010569)2.40463448
134microtubule polymerization or depolymerization (GO:0031109)2.40393539
135sister chromatid segregation (GO:0000819)2.40010646
136protein localization to chromosome (GO:0034502)2.39825904
137protein localization to cilium (GO:0061512)2.39463035
138establishment of chromosome localization (GO:0051303)2.38399260
139epithelial cilium movement (GO:0003351)2.36201353
140male meiosis I (GO:0007141)2.36149277
141double-strand break repair via nonhomologous end joining (GO:0006303)2.34515573
142non-recombinational repair (GO:0000726)2.34515573
143retinal ganglion cell axon guidance (GO:0031290)2.34018732
144replication fork processing (GO:0031297)2.28558112
145protein localization to kinetochore (GO:0034501)2.27918247
146meiotic cell cycle process (GO:1903046)2.25712147
147neuromuscular synaptic transmission (GO:0007274)2.25633027
148central nervous system neuron axonogenesis (GO:0021955)2.25198807
149microtubule depolymerization (GO:0007019)2.24232102
150regulation of centriole replication (GO:0046599)2.23547842
151microtubule nucleation (GO:0007020)2.22919731
152positive regulation of mitochondrial fission (GO:0090141)2.22631713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66589964
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.01128104
3GBX2_23144817_ChIP-Seq_PC3_Human3.90229613
4E2F7_22180533_ChIP-Seq_HELA_Human3.15399420
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08791100
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00670243
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95325348
8REST_21632747_ChIP-Seq_MESCs_Mouse2.68014814
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61243987
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58675090
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55640998
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55640998
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.54366010
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51865379
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51241610
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48638181
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42921712
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42344999
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41405031
20DROSHA_22980978_ChIP-Seq_HELA_Human2.40133760
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.39274671
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.33737619
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.28207401
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17772411
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.15843868
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.14577100
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13289583
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.11014928
29* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10855066
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.07748650
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02119544
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99871323
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98163560
34TAF15_26573619_Chip-Seq_HEK293_Human1.95136302
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95068167
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93995758
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91856712
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89563746
39AR_21572438_ChIP-Seq_LNCaP_Human1.88549651
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87826638
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84776892
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84570072
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81731599
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.79328542
45EWS_26573619_Chip-Seq_HEK293_Human1.79034926
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77406902
47* SMAD4_21799915_ChIP-Seq_A2780_Human1.76203957
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71173288
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70649819
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69896073
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64487038
52* P300_19829295_ChIP-Seq_ESCs_Human1.58952160
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58577022
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58255617
55HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.57747966
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55608647
57ELK1_19687146_ChIP-ChIP_HELA_Human1.52714760
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51872349
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.47985603
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47209429
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47018262
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43430148
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.40289694
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40248517
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.38825790
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37477302
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.35667082
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.35454421
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35169211
70SOX9_26525672_Chip-Seq_HEART_Mouse1.34803175
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.34549130
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33132979
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.33005290
74* AR_25329375_ChIP-Seq_VCAP_Human1.32034917
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31800011
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31190351
77* VDR_23849224_ChIP-Seq_CD4+_Human1.31069568
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30474711
79FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.30470510
80STAT3_23295773_ChIP-Seq_U87_Human1.30207789
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30023877
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29969477
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29113672
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28225468
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26052013
86ZNF274_21170338_ChIP-Seq_K562_Hela1.25459101
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23876201
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.23770140
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.23002390
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20341537
91FUS_26573619_Chip-Seq_HEK293_Human1.19810248
92AR_19668381_ChIP-Seq_PC3_Human1.18883235
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18149260
94RNF2_27304074_Chip-Seq_NSC_Mouse1.18123527
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17482401
96TCF4_23295773_ChIP-Seq_U87_Human1.16583980
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.16118859
98VDR_22108803_ChIP-Seq_LS180_Human1.16117336
99* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14364248
100IGF1R_20145208_ChIP-Seq_DFB_Human1.13500218
101GATA1_26923725_Chip-Seq_HPCs_Mouse1.13261560
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12445115
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12260085
104* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10912336
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.10664626
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10489280
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08803482
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.08519178
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08101203
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07381668
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06248957
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05873054
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04927931
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04806493
115MYC_18940864_ChIP-ChIP_HL60_Human1.03880420
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03853854
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03384579
118ER_23166858_ChIP-Seq_MCF-7_Human1.03109573
119RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02916100
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02665076
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02299887
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02294566
123UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01508991
124E2F1_21310950_ChIP-Seq_MCF-7_Human1.01445171
125* RUNX2_22187159_ChIP-Seq_PCA_Human1.01069269
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.00976996
127AHR_22903824_ChIP-Seq_MCF-7_Human1.00086707
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99102127
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.99087936
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98666478
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98666478
132IRF1_19129219_ChIP-ChIP_H3396_Human0.97663738
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96585940
134* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95945787
135CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95117876
136KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94707655
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94589082
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94444470
139JUN_21703547_ChIP-Seq_K562_Human0.94338409
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.94046775
141CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92865756
142MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92831408
143TP53_18474530_ChIP-ChIP_U2OS_Human0.92449066
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88069180
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.87927379
146SMAD3_21741376_ChIP-Seq_HESCs_Human0.87038547
147RXR_22108803_ChIP-Seq_LS180_Human0.85700385
148BCAT_22108803_ChIP-Seq_LS180_Human0.85522340
149TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85307365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.08822796
2MP0003880_abnormal_central_pattern5.14679587
3* MP0003635_abnormal_synaptic_transmissio4.07378738
4MP0004270_analgesia3.47880747
5* MP0009745_abnormal_behavioral_response3.43556250
6MP0002063_abnormal_learning/memory/cond3.33399878
7MP0009046_muscle_twitch3.29851090
8* MP0002064_seizures3.29826342
9MP0001968_abnormal_touch/_nociception3.21720804
10MP0002572_abnormal_emotion/affect_behav2.91339281
11MP0005423_abnormal_somatic_nervous2.78941729
12MP0008877_abnormal_DNA_methylation2.76985477
13MP0002736_abnormal_nociception_after2.70640745
14MP0002734_abnormal_mechanical_nocicepti2.63423011
15* MP0002272_abnormal_nervous_system2.59382159
16MP0001486_abnormal_startle_reflex2.55156339
17MP0002822_catalepsy2.53580550
18MP0001501_abnormal_sleep_pattern2.41525296
19MP0002735_abnormal_chemical_nociception2.36776175
20MP0008058_abnormal_DNA_repair2.25035896
21MP0001440_abnormal_grooming_behavior2.21606845
22MP0009780_abnormal_chondrocyte_physiolo2.19941910
23MP0002067_abnormal_sensory_capabilities2.14363407
24MP0003136_yellow_coat_color2.12702372
25MP0002102_abnormal_ear_morphology2.07627072
26MP0010094_abnormal_chromosome_stability2.01224104
27MP0005646_abnormal_pituitary_gland1.97392651
28MP0001970_abnormal_pain_threshold1.96532194
29MP0002733_abnormal_thermal_nociception1.94043933
30MP0000778_abnormal_nervous_system1.87850484
31MP0008569_lethality_at_weaning1.87589066
32MP0004924_abnormal_behavior1.81186617
33MP0005386_behavior/neurological_phenoty1.81186617
34MP0008057_abnormal_DNA_replication1.80532877
35MP0001984_abnormal_olfaction1.76920719
36MP0002557_abnormal_social/conspecific_i1.76237685
37MP0002184_abnormal_innervation1.74380059
38MP0006276_abnormal_autonomic_nervous1.70361651
39MP0003329_amyloid_beta_deposits1.70235827
40MP0003787_abnormal_imprinting1.68244952
41MP0004811_abnormal_neuron_physiology1.65350317
42MP0008789_abnormal_olfactory_epithelium1.60185994
43MP0004858_abnormal_nervous_system1.59623196
44MP0001529_abnormal_vocalization1.57967824
45MP0003879_abnormal_hair_cell1.57121250
46MP0002909_abnormal_adrenal_gland1.55833009
47MP0003121_genomic_imprinting1.54376001
48MP0003693_abnormal_embryo_hatching1.48971104
49MP0001502_abnormal_circadian_rhythm1.48081623
50MP0001905_abnormal_dopamine_level1.46758161
51MP0005551_abnormal_eye_electrophysiolog1.45147471
52MP0000372_irregular_coat_pigmentation1.44576479
53MP0000955_abnormal_spinal_cord1.44267542
54* MP0002882_abnormal_neuron_morphology1.42495537
55MP0000566_synostosis1.42210477
56MP0002066_abnormal_motor_capabilities/c1.41337834
57MP0004142_abnormal_muscle_tone1.38792825
58MP0003633_abnormal_nervous_system1.34295693
59MP0003122_maternal_imprinting1.32481571
60MP0001188_hyperpigmentation1.31382850
61MP0003111_abnormal_nucleus_morphology1.27911135
62MP0010386_abnormal_urinary_bladder1.27703877
63MP0005174_abnormal_tail_pigmentation1.26465008
64MP0005645_abnormal_hypothalamus_physiol1.25154651
65MP0004885_abnormal_endolymph1.21853813
66MP0002210_abnormal_sex_determination1.20427740
67MP0001346_abnormal_lacrimal_gland1.20190434
68MP0001929_abnormal_gametogenesis1.18409622
69MP0003077_abnormal_cell_cycle1.17532409
70MP0003631_nervous_system_phenotype1.14259918
71MP0003861_abnormal_nervous_system1.09409662
72MP0002229_neurodegeneration1.08472518
73MP0003698_abnormal_male_reproductive1.07455620
74MP0000569_abnormal_digit_pigmentation1.07098431
75* MP0002152_abnormal_brain_morphology1.06170094
76MP0001299_abnormal_eye_distance/1.02007700
77MP0004742_abnormal_vestibular_system1.01820502
78MP0006292_abnormal_olfactory_placode1.01191936
79MP0003690_abnormal_glial_cell0.98154948
80MP0003634_abnormal_glial_cell0.96416730
81MP0003938_abnormal_ear_development0.95476718
82MP0000015_abnormal_ear_pigmentation0.94231710
83MP0002095_abnormal_skin_pigmentation0.93769432
84MP0008872_abnormal_physiological_respon0.92925822
85MP0002069_abnormal_eating/drinking_beha0.92270112
86MP0002090_abnormal_vision0.90808602
87MP0002233_abnormal_nose_morphology0.90389478
88MP0002876_abnormal_thyroid_physiology0.89985573
89MP0001145_abnormal_male_reproductive0.87919248
90MP0001963_abnormal_hearing_physiology0.87571910
91MP0000653_abnormal_sex_gland0.86756150
92MP0002751_abnormal_autonomic_nervous0.86110436
93MP0008874_decreased_physiological_sensi0.85269378
94MP0000920_abnormal_myelination0.85029074
95MP0000013_abnormal_adipose_tissue0.85016939
96MP0005535_abnormal_body_temperature0.84698990
97MP0004145_abnormal_muscle_electrophysio0.83726108
98MP0002837_dystrophic_cardiac_calcinosis0.83604509
99MP0000751_myopathy0.83428165
100MP0003183_abnormal_peptide_metabolism0.83046832
101MP0002938_white_spotting0.82691943
102MP0003632_abnormal_nervous_system0.82626003
103MP0002752_abnormal_somatic_nervous0.81278369
104MP0000631_abnormal_neuroendocrine_gland0.81170339
105MP0002177_abnormal_outer_ear0.79830783
106MP0002234_abnormal_pharynx_morphology0.79769400
107MP0000604_amyloidosis0.79677058
108MP0003937_abnormal_limbs/digits/tail_de0.77432818
109MP0004957_abnormal_blastocyst_morpholog0.77068682
110MP0001293_anophthalmia0.76666581
111MP0001177_atelectasis0.76412455
112MP0010030_abnormal_orbit_morphology0.75751136
113MP0008932_abnormal_embryonic_tissue0.75513769
114MP0004510_myositis0.75100328
115MP0001986_abnormal_taste_sensitivity0.74908700
116MP0005187_abnormal_penis_morphology0.74735447
117MP0005248_abnormal_Harderian_gland0.74051312
118MP0004085_abnormal_heartbeat0.73699391
119MP0005394_taste/olfaction_phenotype0.73399871
120MP0005499_abnormal_olfactory_system0.73399871
121MP0006072_abnormal_retinal_apoptosis0.69902997
122MP0008961_abnormal_basal_metabolism0.69551503
123MP0003075_altered_response_to0.67982477
124MP0002638_abnormal_pupillary_reflex0.67447293
125MP0005623_abnormal_meninges_morphology0.66895070
126MP0001664_abnormal_digestion0.64757614
127MP0005171_absent_coat_pigmentation0.64657167
128MP0005253_abnormal_eye_physiology0.64223516
129MP0005409_darkened_coat_color0.60231090
130MP0004484_altered_response_of0.60007745
131MP0004215_abnormal_myocardial_fiber0.57434512
132MP0002653_abnormal_ependyma_morphology0.56991728
133MP0001943_abnormal_respiration0.56374995
134MP0000026_abnormal_inner_ear0.53915021
135MP0001485_abnormal_pinna_reflex0.53485124
136MP0010769_abnormal_survival0.49519771
137MP0003283_abnormal_digestive_organ0.49420886
138MP0002082_postnatal_lethality0.48722840
139MP0010770_preweaning_lethality0.48722840

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.78468022
2Myokymia (HP:0002411)5.95418328
3Epileptic encephalopathy (HP:0200134)5.64396358
4Focal seizures (HP:0007359)5.61970718
5Atonic seizures (HP:0010819)5.40505607
6Visual hallucinations (HP:0002367)5.12384307
7Febrile seizures (HP:0002373)4.84813510
8Absence seizures (HP:0002121)4.47696606
9Progressive cerebellar ataxia (HP:0002073)4.24278203
10Hyperventilation (HP:0002883)4.13904757
11Dialeptic seizures (HP:0011146)4.13205407
12Generalized tonic-clonic seizures (HP:0002069)3.93502970
13Broad-based gait (HP:0002136)3.83150802
14Action tremor (HP:0002345)3.42580361
15Supranuclear gaze palsy (HP:0000605)3.38096149
16Gaze-evoked nystagmus (HP:0000640)3.28511676
17Poor eye contact (HP:0000817)3.20105092
18Abnormal eating behavior (HP:0100738)3.09993949
19Oligodactyly (hands) (HP:0001180)3.08355045
20Truncal ataxia (HP:0002078)3.07089436
21Dysdiadochokinesis (HP:0002075)3.05561212
22Ankle clonus (HP:0011448)3.01485845
23Depression (HP:0000716)3.01226480
24Cerebral hypomyelination (HP:0006808)3.01201537
25Amblyopia (HP:0000646)2.98044114
26Abnormality of the labia minora (HP:0012880)2.97777047
27Dysmetria (HP:0001310)2.97330264
28Impaired vibration sensation in the lower limbs (HP:0002166)2.97262712
29Excessive salivation (HP:0003781)2.94726621
30Drooling (HP:0002307)2.94726621
31Ependymoma (HP:0002888)2.93412832
32Progressive inability to walk (HP:0002505)2.89436923
33Urinary bladder sphincter dysfunction (HP:0002839)2.87540994
34Abnormal social behavior (HP:0012433)2.84582839
35Impaired social interactions (HP:0000735)2.84582839
36Volvulus (HP:0002580)2.83186302
37Colon cancer (HP:0003003)2.81553815
38Mutism (HP:0002300)2.79472351
39Intestinal atresia (HP:0011100)2.78726826
40Anxiety (HP:0000739)2.71751251
41Abnormality of the astrocytes (HP:0100707)2.70932763
42Astrocytoma (HP:0009592)2.70932763
43Abnormality of binocular vision (HP:0011514)2.68803981
44Diplopia (HP:0000651)2.68803981
45Absent speech (HP:0001344)2.61029123
46Limb dystonia (HP:0002451)2.59411283
47Epileptiform EEG discharges (HP:0011182)2.58456280
48Inability to walk (HP:0002540)2.58176707
49Postural instability (HP:0002172)2.57591049
50Neurofibrillary tangles (HP:0002185)2.56953724
51Hemiparesis (HP:0001269)2.56672959
52Cerebral inclusion bodies (HP:0100314)2.55657028
53Medulloblastoma (HP:0002885)2.52825784
54Gait imbalance (HP:0002141)2.51323485
55Genetic anticipation (HP:0003743)2.47910615
56Polyphagia (HP:0002591)2.47089597
57Spastic gait (HP:0002064)2.46504890
58Impaired smooth pursuit (HP:0007772)2.45610807
59Agnosia (HP:0010524)2.44461507
60Pheochromocytoma (HP:0002666)2.43425177
61Scanning speech (HP:0002168)2.42077678
62EEG with generalized epileptiform discharges (HP:0011198)2.40756746
63Papilledema (HP:0001085)2.40258974
64Oligodactyly (HP:0012165)2.38899379
65Abnormality of the corticospinal tract (HP:0002492)2.34453248
66Protruding tongue (HP:0010808)2.33273760
67Rhabdomyosarcoma (HP:0002859)2.31327620
68Glioma (HP:0009733)2.30902670
69Bradykinesia (HP:0002067)2.30874637
70Urinary urgency (HP:0000012)2.30173164
71Stereotypic behavior (HP:0000733)2.30123073
72Intention tremor (HP:0002080)2.26293322
73Hypsarrhythmia (HP:0002521)2.23982846
74Insidious onset (HP:0003587)2.22360421
75Termporal pattern (HP:0011008)2.22360421
76Status epilepticus (HP:0002133)2.22102958
77Hemiplegia (HP:0002301)2.22067275
78Torticollis (HP:0000473)2.21781417
79CNS hypomyelination (HP:0003429)2.21022997
80Generalized myoclonic seizures (HP:0002123)2.20563704
81Fetal akinesia sequence (HP:0001989)2.17955059
82Neuroendocrine neoplasm (HP:0100634)2.17642177
83Abnormality of ocular smooth pursuit (HP:0000617)2.15687264
84Congenital primary aphakia (HP:0007707)2.14729969
85Abnormal hair whorl (HP:0010721)2.12492458
86Specific learning disability (HP:0001328)2.11268118
87Focal dystonia (HP:0004373)2.09207242
88Lower limb muscle weakness (HP:0007340)2.08964565
89Blue irides (HP:0000635)2.08027994
90Dysmetric saccades (HP:0000641)2.06920149
91Medial flaring of the eyebrow (HP:0010747)2.05832639
92Megalencephaly (HP:0001355)2.05363318
93Peripheral hypomyelination (HP:0007182)2.05036859
94Central scotoma (HP:0000603)2.03361504
95Abnormal lung lobation (HP:0002101)2.01715954
96Abnormality of the lower motor neuron (HP:0002366)2.00080877
97Abnormality of salivation (HP:0100755)1.99508720
98Impaired vibratory sensation (HP:0002495)1.98204762
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97869726
100Failure to thrive in infancy (HP:0001531)1.97048538
101Agitation (HP:0000713)1.96705694
102Unsteady gait (HP:0002317)1.96589459
103Neoplasm of the oral cavity (HP:0100649)1.96465261
104Nephrogenic diabetes insipidus (HP:0009806)1.95800413
105Neuroblastic tumors (HP:0004376)1.95127650
106Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.95127650
107Neuroblastoma (HP:0003006)1.95127650
108Primitive neuroectodermal tumor (HP:0030065)1.95127650
109Gait ataxia (HP:0002066)1.93997945
110Psychosis (HP:0000709)1.93626084
111Cortical dysplasia (HP:0002539)1.93459430
112Hyperthyroidism (HP:0000836)1.92786807
113Retinal dysplasia (HP:0007973)1.92654344
114Incomplete penetrance (HP:0003829)1.91825297
115Neuronal loss in central nervous system (HP:0002529)1.91376283
116Chromsome breakage (HP:0040012)1.89361184
117Tubulointerstitial nephritis (HP:0001970)1.87369608
118Poor coordination (HP:0002370)1.85536206
119Abnormality of macular pigmentation (HP:0008002)1.84687592
120Akinesia (HP:0002304)1.83938509
121Pancreatic fibrosis (HP:0100732)1.82528059
122Degeneration of the lateral corticospinal tracts (HP:0002314)1.81694369
123Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81694369
124Gastrointestinal atresia (HP:0002589)1.81131312
125Molar tooth sign on MRI (HP:0002419)1.81039653
126Abnormality of midbrain morphology (HP:0002418)1.81039653
127Craniofacial dystonia (HP:0012179)1.80945944
128Vaginal atresia (HP:0000148)1.79884261
129Hypoventilation (HP:0002791)1.79732240
130Genital tract atresia (HP:0001827)1.77942777
131Preaxial hand polydactyly (HP:0001177)1.76341292
132Neoplasm of striated muscle (HP:0009728)1.76054505
133Abnormality of saccadic eye movements (HP:0000570)1.75912829
134Delusions (HP:0000746)1.75793003
135Upper limb muscle weakness (HP:0003484)1.74429975
136Thickened helices (HP:0000391)1.74340154
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.73112359
138Spastic tetraplegia (HP:0002510)1.71692683
139Chronic hepatic failure (HP:0100626)1.70761293
140Abnormality of the ileum (HP:0001549)1.70336637
141Degeneration of anterior horn cells (HP:0002398)1.68873654
142Abnormality of the anterior horn cell (HP:0006802)1.68873654
143Postnatal microcephaly (HP:0005484)1.68330428
144Abnormality of chromosome segregation (HP:0002916)1.68169704
145Meckel diverticulum (HP:0002245)1.68162130
146Increased nuchal translucency (HP:0010880)1.66476886
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.66474173
148True hermaphroditism (HP:0010459)1.65447465
149Amyotrophic lateral sclerosis (HP:0007354)1.64062914
150Papillary thyroid carcinoma (HP:0002895)1.63680970
151Abnormality of chromosome stability (HP:0003220)1.63226181
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62802134
153Astigmatism (HP:0000483)1.62442821
154Aqueductal stenosis (HP:0002410)1.62255409
155Neuroectodermal neoplasm (HP:0030061)1.61922704
156Neuroepithelial neoplasm (HP:0030063)1.61922704
157Nervous tissue neoplasm (HP:0030060)1.61922704
158Shoulder girdle muscle weakness (HP:0003547)1.61824231
159Postaxial hand polydactyly (HP:0001162)1.60009831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.33170334
2EPHA43.88626164
3CASK3.55144219
4MAP3K93.45186098
5MAP3K43.17420561
6MAP2K72.89297296
7MARK12.72315983
8DAPK22.56288192
9MAP3K122.48282266
10MINK12.44383162
11TRIM282.25423205
12STK162.14513840
13PAK62.11905738
14CDK192.10327028
15RIPK42.03512307
16NTRK22.02164710
17TSSK62.00905987
18MAP2K41.98199066
19PLK21.84217497
20TNIK1.82589224
21MAP4K21.82304501
22WEE11.74021734
23BMPR1B1.72829123
24KSR21.68390365
25PRPF4B1.67412609
26DAPK11.63909199
27PRKD31.63387793
28WNK31.60686862
29TTK1.56722081
30CDC71.55702178
31PNCK1.54545421
32CDK51.51553139
33CAMKK11.51057499
34PLK41.46620732
35KSR11.46599757
36MAPK131.44055811
37BRSK11.43043922
38NTRK11.42446058
39GRK51.41569088
40NEK11.41524513
41SRPK11.40652427
42ARAF1.37645567
43PLK31.32038681
44SIK21.29959489
45FES1.28866235
46MAP3K131.27916555
47OXSR11.26675959
48CAMKK21.21287483
49EIF2AK31.21198974
50CCNB11.19378179
51PRKCG1.18587331
52BRD41.16890682
53PBK1.11116955
54CAMK2A1.05515140
55SGK2231.05090591
56SGK4941.05090591
57MKNK21.03789349
58PLK11.03176599
59STK381.02131044
60BMPR21.00741685
61BRSK20.99478861
62ACVR1B0.98173942
63UHMK10.94935217
64CDK180.91243103
65SGK20.88952716
66EIF2AK10.88236528
67CDK150.87742790
68CDK140.86432974
69BUB10.86180145
70PTK2B0.83819698
71PRKCH0.83794679
72TYRO30.83682762
73CSNK1G10.82885417
74CAMK2B0.82691005
75STK110.80549028
76PASK0.80161599
77AKT30.79356055
78PHKG20.78124504
79PHKG10.78124504
80DYRK1A0.77719123
81CAMK10.76966939
82DYRK20.76638192
83CSNK1G30.76084020
84MKNK10.76067303
85ATR0.76024594
86CDK11A0.75511794
87VRK10.73867687
88PAK30.71724545
89RET0.70202043
90MAP3K20.70104025
91NUAK10.68829943
92SGK10.68380240
93CSNK1G20.68254706
94CSNK1A1L0.67579032
95NME10.65384365
96SGK30.65211628
97FGR0.64173667
98PRKCE0.63966801
99ATM0.63343522
100CHEK10.63080215
101TNK20.62370618
102SIK30.60909286
103RAF10.58790077
104PDK10.57677524
105BCR0.57005063
106FRK0.56219448
107ERBB30.55047147
108CAMK2D0.52541152
109LATS20.51440320
110MARK20.50663066
111CDK30.50621499
112NEK60.49799354
113PDPK10.49320795
114PRKDC0.49167992
115MARK30.48366075
116FER0.47950673
117TAF10.47799052
118FGFR20.47376528
119CAMK1G0.47375125
120ADRBK20.47112554
121BRAF0.46828974
122ROCK20.46457346
123TAOK10.46123160
124FYN0.45920020
125CSNK1E0.45715444
126PRKCI0.45303459
127CHEK20.45294820
128MST40.44667866
129CDC42BPA0.44154444
130AURKA0.43984850
131CAMK2G0.43417751
132PRKCZ0.42960050
133RPS6KA30.42418056
134ADRBK10.42290873
135DAPK30.41803307
136MAP3K10.41176388
137MAPK120.40833288
138PINK10.40521321
139PKN10.39039782
140WNK10.38877297
141LMTK20.37882861
142MAP3K60.37178328
143MAPK100.35888821
144ALK0.34856414
145MAPKAPK50.33822496
146CAMK40.31873371
147STK390.29920575

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.95952464
2Synaptic vesicle cycle_Homo sapiens_hsa047213.68418358
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81124702
4GABAergic synapse_Homo sapiens_hsa047272.74979194
5Mismatch repair_Homo sapiens_hsa034302.64857496
6Circadian entrainment_Homo sapiens_hsa047132.61693020
7Olfactory transduction_Homo sapiens_hsa047402.60795931
8Morphine addiction_Homo sapiens_hsa050322.58429753
9Long-term potentiation_Homo sapiens_hsa047202.55549597
10Glutamatergic synapse_Homo sapiens_hsa047242.53913619
11Protein export_Homo sapiens_hsa030602.37405112
12Amphetamine addiction_Homo sapiens_hsa050312.37114666
13Non-homologous end-joining_Homo sapiens_hsa034502.36995618
14Collecting duct acid secretion_Homo sapiens_hsa049662.16618910
15Fanconi anemia pathway_Homo sapiens_hsa034602.10644562
16Dopaminergic synapse_Homo sapiens_hsa047282.10219923
17Salivary secretion_Homo sapiens_hsa049702.03690894
18Insulin secretion_Homo sapiens_hsa049111.98412494
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92066857
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91518137
21Taste transduction_Homo sapiens_hsa047421.83488481
22Serotonergic synapse_Homo sapiens_hsa047261.80485946
23Cholinergic synapse_Homo sapiens_hsa047251.80248873
24Cell cycle_Homo sapiens_hsa041101.73636890
25Gastric acid secretion_Homo sapiens_hsa049711.73334523
26Long-term depression_Homo sapiens_hsa047301.72847493
27Renin secretion_Homo sapiens_hsa049241.72104320
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66497753
29RNA degradation_Homo sapiens_hsa030181.63481482
30Homologous recombination_Homo sapiens_hsa034401.62513566
31DNA replication_Homo sapiens_hsa030301.62413119
32Oxytocin signaling pathway_Homo sapiens_hsa049211.58471503
33Cocaine addiction_Homo sapiens_hsa050301.58192044
34RNA transport_Homo sapiens_hsa030131.57772491
35RNA polymerase_Homo sapiens_hsa030201.54955321
36Calcium signaling pathway_Homo sapiens_hsa040201.54840873
37Base excision repair_Homo sapiens_hsa034101.50957323
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46702607
39Nucleotide excision repair_Homo sapiens_hsa034201.43178349
40mRNA surveillance pathway_Homo sapiens_hsa030151.43114381
41Basal transcription factors_Homo sapiens_hsa030221.42620765
42Spliceosome_Homo sapiens_hsa030401.41150294
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34765837
44Vibrio cholerae infection_Homo sapiens_hsa051101.34758366
45Phototransduction_Homo sapiens_hsa047441.34621374
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32051665
47GnRH signaling pathway_Homo sapiens_hsa049121.31353874
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29221390
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29137841
50Gap junction_Homo sapiens_hsa045401.23917586
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20605169
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18970508
53cAMP signaling pathway_Homo sapiens_hsa040241.17945033
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15912857
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15081503
56Proteasome_Homo sapiens_hsa030501.13617551
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13298795
58Huntingtons disease_Homo sapiens_hsa050161.10368347
59Axon guidance_Homo sapiens_hsa043601.09301335
60Type II diabetes mellitus_Homo sapiens_hsa049301.08708667
61Hedgehog signaling pathway_Homo sapiens_hsa043401.05307204
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05072191
63ErbB signaling pathway_Homo sapiens_hsa040121.02262525
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01811787
65Estrogen signaling pathway_Homo sapiens_hsa049151.01618828
66Glioma_Homo sapiens_hsa052140.98260555
67Cardiac muscle contraction_Homo sapiens_hsa042600.94102044
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94055923
69Regulation of autophagy_Homo sapiens_hsa041400.92065224
70Melanogenesis_Homo sapiens_hsa049160.91343578
71Propanoate metabolism_Homo sapiens_hsa006400.90604454
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.89025971
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88069927
74Steroid biosynthesis_Homo sapiens_hsa001000.83491133
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82245221
76Type I diabetes mellitus_Homo sapiens_hsa049400.77582441
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76313592
78Dorso-ventral axis formation_Homo sapiens_hsa043200.76143023
79Pancreatic secretion_Homo sapiens_hsa049720.73919267
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73489215
81MAPK signaling pathway_Homo sapiens_hsa040100.72760248
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.70371449
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70186551
84Hippo signaling pathway_Homo sapiens_hsa043900.69667153
85Dilated cardiomyopathy_Homo sapiens_hsa054140.68994987
86Rheumatoid arthritis_Homo sapiens_hsa053230.68438313
87Oocyte meiosis_Homo sapiens_hsa041140.68408754
88Butanoate metabolism_Homo sapiens_hsa006500.67580245
89Purine metabolism_Homo sapiens_hsa002300.65585351
90Basal cell carcinoma_Homo sapiens_hsa052170.65303595
91Thyroid hormone synthesis_Homo sapiens_hsa049180.63825735
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62466446
93Colorectal cancer_Homo sapiens_hsa052100.62074690
94Choline metabolism in cancer_Homo sapiens_hsa052310.60772496
95Ras signaling pathway_Homo sapiens_hsa040140.59923910
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59296649
97Pyrimidine metabolism_Homo sapiens_hsa002400.58456030
98Circadian rhythm_Homo sapiens_hsa047100.58337641
99Alzheimers disease_Homo sapiens_hsa050100.57354386
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56910680
101Oxidative phosphorylation_Homo sapiens_hsa001900.56544106
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54942210
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.53840068
104Inositol phosphate metabolism_Homo sapiens_hsa005620.53735714
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53597060
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52689779
107VEGF signaling pathway_Homo sapiens_hsa043700.52123035
108p53 signaling pathway_Homo sapiens_hsa041150.51658677
109beta-Alanine metabolism_Homo sapiens_hsa004100.51461593
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.51212880
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49461643
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47869769
113Rap1 signaling pathway_Homo sapiens_hsa040150.45699657
114African trypanosomiasis_Homo sapiens_hsa051430.45627110
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45501479
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.45237742
117Renal cell carcinoma_Homo sapiens_hsa052110.44988377
118Endocytosis_Homo sapiens_hsa041440.44100016
119Chemokine signaling pathway_Homo sapiens_hsa040620.43309403
120Alcoholism_Homo sapiens_hsa050340.42752726
121Prion diseases_Homo sapiens_hsa050200.41893437
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41716186
123Phagosome_Homo sapiens_hsa041450.41644337
124Pyruvate metabolism_Homo sapiens_hsa006200.41636995
125Glucagon signaling pathway_Homo sapiens_hsa049220.40543632
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39272467
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39081680
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38109823
129Wnt signaling pathway_Homo sapiens_hsa043100.38101166
130mTOR signaling pathway_Homo sapiens_hsa041500.36815412
131Endometrial cancer_Homo sapiens_hsa052130.32876617
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32734039
133Ovarian steroidogenesis_Homo sapiens_hsa049130.32195648
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30578057
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29890063
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29458986
137Non-small cell lung cancer_Homo sapiens_hsa052230.29216261
138Parkinsons disease_Homo sapiens_hsa050120.28154229
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26012251
140Insulin signaling pathway_Homo sapiens_hsa049100.25042760
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24845930

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