AP1M1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.68799906
2DNA strand elongation involved in DNA replication (GO:0006271)4.74546741
3telomere maintenance via semi-conservative replication (GO:0032201)4.60847360
4DNA strand elongation (GO:0022616)4.54844431
5ribosomal small subunit assembly (GO:0000028)4.52846313
6fucose catabolic process (GO:0019317)4.50853772
7L-fucose metabolic process (GO:0042354)4.50853772
8L-fucose catabolic process (GO:0042355)4.50853772
9DNA deamination (GO:0045006)4.49964364
10negative regulation of telomere maintenance (GO:0032205)4.21560895
11gamma-aminobutyric acid transport (GO:0015812)4.15707470
12kynurenine metabolic process (GO:0070189)3.99649101
13telomere maintenance via recombination (GO:0000722)3.93233631
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.92616270
15negative regulation of synaptic transmission, GABAergic (GO:0032229)3.88053556
16indolalkylamine catabolic process (GO:0046218)3.79591741
17tryptophan catabolic process (GO:0006569)3.79591741
18indole-containing compound catabolic process (GO:0042436)3.79591741
19protein deneddylation (GO:0000338)3.74068553
20cellular response to exogenous dsRNA (GO:0071360)3.69013648
21negative regulation of mast cell activation (GO:0033004)3.68496605
22mitotic recombination (GO:0006312)3.59941864
23indolalkylamine metabolic process (GO:0006586)3.58499506
24cullin deneddylation (GO:0010388)3.57269151
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.54462817
26detection of light stimulus involved in visual perception (GO:0050908)3.54217170
27detection of light stimulus involved in sensory perception (GO:0050962)3.54217170
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.52414023
29sulfation (GO:0051923)3.51017681
30negative regulation of RNA splicing (GO:0033119)3.50189514
31histone H2A acetylation (GO:0043968)3.49347950
32DNA unwinding involved in DNA replication (GO:0006268)3.48709156
33formation of translation preinitiation complex (GO:0001731)3.47101489
34DNA replication initiation (GO:0006270)3.45444589
35sequestering of actin monomers (GO:0042989)3.44912282
36primary amino compound metabolic process (GO:1901160)3.44830967
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.41778015
38telomere maintenance via telomere lengthening (GO:0010833)3.38391598
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.38269309
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.38269309
41NADH dehydrogenase complex assembly (GO:0010257)3.38269309
42positive regulation of CREB transcription factor activity (GO:0032793)3.36937861
43positive regulation of defense response to virus by host (GO:0002230)3.34853878
44viral mRNA export from host cell nucleus (GO:0046784)3.34469947
45tolerance induction (GO:0002507)3.32160834
46postreplication repair (GO:0006301)3.30034965
47ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.29309227
48cellular response to ATP (GO:0071318)3.28419260
49viral transcription (GO:0019083)3.25185269
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.24503538
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21569680
52fucosylation (GO:0036065)3.20554538
53tryptophan metabolic process (GO:0006568)3.19802121
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19694239
55protein import into peroxisome matrix (GO:0016558)3.18106450
56anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17964185
57negative regulation of ligase activity (GO:0051352)3.15963826
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15963826
59translational elongation (GO:0006414)3.14521495
60de novo posttranslational protein folding (GO:0051084)3.13563027
61response to misfolded protein (GO:0051788)3.13510120
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12891201
63serotonin metabolic process (GO:0042428)3.12280038
64membrane depolarization during action potential (GO:0086010)3.10384757
65indole-containing compound metabolic process (GO:0042430)3.07749980
66translational termination (GO:0006415)3.06710190
67cellular ketone body metabolic process (GO:0046950)3.05250509
68cardiovascular system development (GO:0072358)3.03549340
69opioid receptor signaling pathway (GO:0038003)3.02812462
70translesion synthesis (GO:0019985)3.00725247
71ubiquinone biosynthetic process (GO:0006744)2.99972406
72nucleobase biosynthetic process (GO:0046112)2.99683656
73nucleosome disassembly (GO:0006337)2.97660813
74protein-DNA complex disassembly (GO:0032986)2.97660813
75de novo protein folding (GO:0006458)2.96107820
76regulation of hippo signaling (GO:0035330)2.92523761
77neuronal action potential (GO:0019228)2.92365023
78protein complex biogenesis (GO:0070271)2.91328348
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90240262
80protein localization to chromosome, centromeric region (GO:0071459)2.87535612
81urinary tract smooth muscle contraction (GO:0014848)2.86759163
82transmission of nerve impulse (GO:0019226)2.86701358
83maturation of SSU-rRNA (GO:0030490)2.86487338
84antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86225922
85antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86225922
86cell proliferation in forebrain (GO:0021846)2.86193014
87DNA replication checkpoint (GO:0000076)2.85978986
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85649237
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85649237
90amine catabolic process (GO:0009310)2.85483714
91cellular biogenic amine catabolic process (GO:0042402)2.85483714
92spliceosomal snRNP assembly (GO:0000387)2.85269295
93purine-containing compound salvage (GO:0043101)2.84805716
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84485733
95SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.83291374
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80149084
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80149084
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80149084
99translational initiation (GO:0006413)2.79368072
100negative regulation of phagocytosis (GO:0050765)2.78667073
101pyrimidine nucleobase catabolic process (GO:0006208)2.77858856
102protein localization to kinetochore (GO:0034501)2.77354592
103protein polyglutamylation (GO:0018095)2.75619817
104binding of sperm to zona pellucida (GO:0007339)2.74706616
105peristalsis (GO:0030432)2.72655927
106cotranslational protein targeting to membrane (GO:0006613)2.72384780
107mitochondrial respiratory chain complex assembly (GO:0033108)2.72291834
108antigen processing and presentation of endogenous antigen (GO:0019883)2.71024961
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.70999020
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.69821439
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69821439
112pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69348829
113protein targeting to ER (GO:0045047)2.68635472
114piRNA metabolic process (GO:0034587)2.68420016
115negative regulation of sodium ion transport (GO:0010766)2.68282936
116antigen processing and presentation via MHC class Ib (GO:0002475)2.68186687
117ketone body metabolic process (GO:1902224)2.68099194
118protein K48-linked deubiquitination (GO:0071108)2.68029356
119synaptic transmission, cholinergic (GO:0007271)2.67671623
120positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67357224
121purine nucleobase biosynthetic process (GO:0009113)2.67265877
122antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66964751
123lysosome localization (GO:0032418)2.65355517
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.64980437
125snRNA transcription (GO:0009301)2.64572214
126negative regulation of systemic arterial blood pressure (GO:0003085)2.63563838
127base-excision repair (GO:0006284)2.63395671
128DNA replication-dependent nucleosome assembly (GO:0006335)2.62364671
129DNA replication-dependent nucleosome organization (GO:0034723)2.62364671
130protein complex disassembly (GO:0043241)2.62245680
131nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.62225993
132cellular protein complex disassembly (GO:0043624)2.62085006
133ubiquinone metabolic process (GO:0006743)2.61393252
134negative regulation of mRNA processing (GO:0050686)2.60739099
135chaperone-mediated protein transport (GO:0072321)2.60590629
136endoderm formation (GO:0001706)2.60069911
137transcription-coupled nucleotide-excision repair (GO:0006283)2.59115799
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.58706202
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.58706202
140regulation of neurotransmitter uptake (GO:0051580)2.58336645
141positive regulation of ligase activity (GO:0051351)2.58131840
142viral life cycle (GO:0019058)2.57921720
143oxidative demethylation (GO:0070989)2.55997181
144preassembly of GPI anchor in ER membrane (GO:0016254)2.55917542
145barbed-end actin filament capping (GO:0051016)2.55805222
146attachment of spindle microtubules to kinetochore (GO:0008608)2.55396426
147neuronal action potential propagation (GO:0019227)2.55238612
148sperm-egg recognition (GO:0035036)2.55030772
149protein localization to endoplasmic reticulum (GO:0070972)2.54924964
150multicellular organism reproduction (GO:0032504)2.54846995
151mitotic nuclear envelope disassembly (GO:0007077)2.54789426
152regulation of ubiquitin-protein transferase activity (GO:0051438)2.54681432
153regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54474890
154mRNA splicing, via spliceosome (GO:0000398)2.54311975
155RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54311975
156positive regulation of fatty acid transport (GO:2000193)2.53503722
157activated T cell proliferation (GO:0050798)2.53145130
158dosage compensation (GO:0007549)2.53044669
159mitotic sister chromatid segregation (GO:0000070)2.53043066
160behavioral response to ethanol (GO:0048149)2.52948410
161regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52101094
162termination of RNA polymerase II transcription (GO:0006369)2.52080466
163macromolecular complex disassembly (GO:0032984)2.52061622
164negative regulation of reactive oxygen species metabolic process (GO:2000378)2.52044172
165NAD biosynthetic process (GO:0009435)2.51908124
166postsynaptic membrane organization (GO:0001941)2.51185183
167regulation of action potential (GO:0098900)2.51076110
168regulation of cellular amino acid metabolic process (GO:0006521)2.50867455
169positive regulation of triglyceride biosynthetic process (GO:0010867)2.50456346
170regulation of respiratory system process (GO:0044065)2.50451739
171G1/S transition of mitotic cell cycle (GO:0000082)2.50356070
172cell cycle G1/S phase transition (GO:0044843)2.50356070
173synaptic transmission, glutamatergic (GO:0035249)2.49922557
174establishment of protein localization to endoplasmic reticulum (GO:0072599)2.49812990
175IMP biosynthetic process (GO:0006188)2.48879377
176RNA splicing, via transesterification reactions (GO:0000375)2.48847998
177positive regulation of fatty acid oxidation (GO:0046321)2.48289737
178cAMP catabolic process (GO:0006198)2.48187885
179interkinetic nuclear migration (GO:0022027)2.48098931
180negative regulation of interleukin-1 production (GO:0032692)2.47017462
181regulation of telomere maintenance (GO:0032204)2.46952471
182epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.45292002
183rhodopsin mediated signaling pathway (GO:0016056)2.43702858
184positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.43563241
185regulation of posttranscriptional gene silencing (GO:0060147)2.43022229
186regulation of gene silencing by miRNA (GO:0060964)2.43022229
187regulation of gene silencing by RNA (GO:0060966)2.43022229
188parturition (GO:0007567)2.42061536
189mitochondrion morphogenesis (GO:0070584)2.41123396
190autophagic vacuole fusion (GO:0000046)2.40217969
191organelle membrane fusion (GO:0090174)2.40003227
192neurotransmitter metabolic process (GO:0042133)2.39749960
193neuromuscular synaptic transmission (GO:0007274)2.39223338
194gamma-aminobutyric acid signaling pathway (GO:0007214)2.38766558
195regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.38313691
196regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.38313691
197L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38144395
198nonmotile primary cilium assembly (GO:0035058)2.37135656
199regulation of mitochondrial fission (GO:0090140)2.35362228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.04374197
2E2F7_22180533_ChIP-Seq_HELA_Human5.97896444
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.15384158
4ZNF274_21170338_ChIP-Seq_K562_Hela3.78763206
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.14951704
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.97462167
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96107607
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86061385
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81489182
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71127808
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.68518979
12* GABP_17652178_ChIP-ChIP_JURKAT_Human2.62493628
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60625631
14MYC_22102868_ChIP-Seq_BL_Human2.59951908
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56434067
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.55885242
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48496359
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.46971997
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40501109
20XRN2_22483619_ChIP-Seq_HELA_Human2.35786015
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35417302
22REST_21632747_ChIP-Seq_MESCs_Mouse2.27116764
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25423385
24CIITA_25753668_ChIP-Seq_RAJI_Human2.24785976
25* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.17662225
26VDR_22108803_ChIP-Seq_LS180_Human2.13618567
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13559383
28GBX2_23144817_ChIP-Seq_PC3_Human2.12658676
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12140482
30MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12032121
31VDR_23849224_ChIP-Seq_CD4+_Human2.07405942
32DROSHA_22980978_ChIP-Seq_HELA_Human2.06874588
33* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03666208
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02134964
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00669838
36* GABP_19822575_ChIP-Seq_HepG2_Human2.00411735
37CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00018940
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.97121596
39VDR_21846776_ChIP-Seq_THP-1_Human1.97102114
40FOXP3_21729870_ChIP-Seq_TREG_Human1.93712136
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.91433798
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91073833
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89536209
44* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87700231
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.84839200
46* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81354262
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79940312
48DCP1A_22483619_ChIP-Seq_HELA_Human1.79834833
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79311072
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76815266
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76149842
52IRF1_19129219_ChIP-ChIP_H3396_Human1.75399126
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.74756942
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73761246
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72722453
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.72215521
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71521959
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71229138
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71034949
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.69033398
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.68391935
62* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67835162
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67343953
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66984246
65TTF2_22483619_ChIP-Seq_HELA_Human1.66320585
66ERA_21632823_ChIP-Seq_H3396_Human1.65909339
67* SRF_21415370_ChIP-Seq_HL-1_Mouse1.64072916
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63874861
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63550975
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.63345845
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.62615645
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61193790
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.61169604
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59609844
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56475611
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55863244
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55680854
78EZH2_27304074_Chip-Seq_ESCs_Mouse1.53312449
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.50118960
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50046540
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49592132
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48818054
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45144442
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44950043
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.43331570
86SPI1_23547873_ChIP-Seq_NB4_Human1.42423984
87TAF2_19829295_ChIP-Seq_ESCs_Human1.42072069
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40061324
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39341581
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39076227
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37450656
92SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36960925
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36950041
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36781376
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36560115
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.36315276
97TP53_22573176_ChIP-Seq_HFKS_Human1.36226652
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36161020
99* SCL_19346495_ChIP-Seq_HPC-7_Human1.36120970
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.36083466
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35306127
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.34624812
103* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34519871
104P68_20966046_ChIP-Seq_HELA_Human1.31193339
105SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29945485
106PHF8_20622854_ChIP-Seq_HELA_Human1.28008702
107E2F1_20622854_ChIP-Seq_HELA_Human1.26768864
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26220685
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.24005893
110RAC3_21632823_ChIP-Seq_H3396_Human1.23924739
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23403538
112CTCF_20526341_ChIP-Seq_ESCs_Human1.22970141
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20714188
114UTX_26944678_Chip-Seq_JUKART_Human1.20177776
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20007555
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19490935
117* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18402754
118NANOG_20526341_ChIP-Seq_ESCs_Human1.18267809
119SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17610495
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.17508719
121ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17401001
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16477571
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15502032
124FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15205754
125FOXA1_25329375_ChIP-Seq_VCAP_Human1.15205754
126* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15123648
127TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13827665
128OCT4_19829295_ChIP-Seq_ESCs_Human1.13744649
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13713880
130MYC_19829295_ChIP-Seq_ESCs_Human1.13451129
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13408085
132AR_21572438_ChIP-Seq_LNCaP_Human1.13100204
133GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11920622
134* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11072001
135MAF_26560356_Chip-Seq_TH1_Human1.10539968
136RUNX1_22412390_ChIP-Seq_EML_Mouse1.10528007
137MYB_26560356_Chip-Seq_TH2_Human1.10362202
138TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09700658
139P300_27268052_Chip-Seq_Bcells_Human1.09389300
140TFEB_21752829_ChIP-Seq_HELA_Human1.09364115
141KDM5A_27292631_Chip-Seq_BREAST_Human1.09355545
142MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09327469
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09137617
144OCT4_20526341_ChIP-Seq_ESCs_Human1.09039792
145MYC_18940864_ChIP-ChIP_HL60_Human1.07615973
146* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07071272
147VDR_24763502_ChIP-Seq_THP-1_Human1.06838991
148NOTCH1_21737748_ChIP-Seq_TLL_Human1.06653549
149RNF2_27304074_Chip-Seq_NSC_Mouse1.06275494
150BCL6_27268052_Chip-Seq_Bcells_Human1.05810086
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04662435
152ER_23166858_ChIP-Seq_MCF-7_Human1.04577081
153* P53_21459846_ChIP-Seq_SAOS-2_Human1.04105623
154SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03980523
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03945502
156MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03754778
157* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02820693
158* ELK1_19687146_ChIP-ChIP_HELA_Human1.02462330
159* BCOR_27268052_Chip-Seq_Bcells_Human1.02260823
160IRF8_21731497_ChIP-ChIP_J774_Mouse1.02182241
161HOXB7_26014856_ChIP-Seq_BT474_Human1.02085724
162EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01604687
163SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00927671
164NCOR_22424771_ChIP-Seq_293T_Human1.00335703
165YY1_22570637_ChIP-Seq_MALME-3M_Human1.00189621
166BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00155405
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99597050
168TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99597050
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99509108
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99506479
171SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99426006
172* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98806007
173RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98293180
174* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98271881
175KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97505637
176* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97112054
177* STAT3_23295773_ChIP-Seq_U87_Human0.96955329
178* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96744262
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96611381
180RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96523232
181E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96093688
182RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95320541
183EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95320541
184PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95292770
185CTCF_27219007_Chip-Seq_Bcells_Human0.94924894
186* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93635580
187EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91330193
188VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89985494
189SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.89401511

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.63805476
2MP0010094_abnormal_chromosome_stability3.24181414
3MP0002396_abnormal_hematopoietic_system2.96378793
4MP0003077_abnormal_cell_cycle2.93834432
5MP0003111_abnormal_nucleus_morphology2.84568004
6MP0009046_muscle_twitch2.79799979
7MP0004957_abnormal_blastocyst_morpholog2.62281933
8MP0001968_abnormal_touch/_nociception2.59474599
9MP0001835_abnormal_antigen_presentation2.49103261
10MP0009745_abnormal_behavioral_response2.43338779
11MP0008007_abnormal_cellular_replicative2.42711465
12MP0008058_abnormal_DNA_repair2.41596366
13MP0004130_abnormal_muscle_cell2.37863042
14MP0004808_abnormal_hematopoietic_stem2.35043768
15MP0003763_abnormal_thymus_physiology2.34813125
16MP0002398_abnormal_bone_marrow2.25180893
17MP0000685_abnormal_immune_system2.20272396
18MP0005671_abnormal_response_to2.12887990
19MP0004142_abnormal_muscle_tone2.12094003
20MP0008057_abnormal_DNA_replication2.10621551
21MP0002272_abnormal_nervous_system2.08288458
22MP0001545_abnormal_hematopoietic_system2.04238799
23MP0005397_hematopoietic_system_phenotyp2.04238799
24MP0002064_seizures2.03205885
25MP0008877_abnormal_DNA_methylation2.00278835
26MP0002733_abnormal_thermal_nociception2.00232634
27MP0008872_abnormal_physiological_respon1.99663610
28MP0005551_abnormal_eye_electrophysiolog1.94456377
29MP0003635_abnormal_synaptic_transmissio1.94322648
30MP0005410_abnormal_fertilization1.90674703
31MP0003195_calcinosis1.90520485
32MP0001970_abnormal_pain_threshold1.87029570
33MP0009333_abnormal_splenocyte_physiolog1.83775989
34MP0002572_abnormal_emotion/affect_behav1.80965708
35MP0008932_abnormal_embryonic_tissue1.80049395
36MP0002063_abnormal_learning/memory/cond1.78736047
37MP0001800_abnormal_humoral_immune1.77523357
38MP0004043_abnormal_pH_regulation1.77053757
39MP0009785_altered_susceptibility_to1.74942472
40MP0004145_abnormal_muscle_electrophysio1.72931486
41MP0000689_abnormal_spleen_morphology1.71839381
42MP0005174_abnormal_tail_pigmentation1.70738114
43MP0002722_abnormal_immune_system1.66664549
44MP0002429_abnormal_blood_cell1.65713470
45MP0000015_abnormal_ear_pigmentation1.65686470
46MP0000716_abnormal_immune_system1.65676484
47MP0000703_abnormal_thymus_morphology1.65383321
48MP0001905_abnormal_dopamine_level1.64744774
49MP0002420_abnormal_adaptive_immunity1.64093212
50MP0000490_abnormal_crypts_of1.64089194
51MP0001819_abnormal_immune_cell1.60557778
52MP0003880_abnormal_central_pattern1.56560797
53MP0005645_abnormal_hypothalamus_physiol1.56360425
54MP0002837_dystrophic_cardiac_calcinosis1.55357782
55MP0006054_spinal_hemorrhage1.54092061
56MP0002452_abnormal_antigen_presenting1.52905851
57MP0004133_heterotaxia1.52059550
58MP0002638_abnormal_pupillary_reflex1.51583930
59MP0005423_abnormal_somatic_nervous1.51556900
60MP0005646_abnormal_pituitary_gland1.50851538
61MP0008875_abnormal_xenobiotic_pharmacok1.50034697
62MP0002653_abnormal_ependyma_morphology1.49482181
63MP0001486_abnormal_startle_reflex1.49304531
64MP0002067_abnormal_sensory_capabilities1.48501425
65MP0003787_abnormal_imprinting1.47790990
66MP0003436_decreased_susceptibility_to1.47763421
67MP0004147_increased_porphyrin_level1.46751358
68MP0002557_abnormal_social/conspecific_i1.45585338
69MP0002723_abnormal_immune_serum1.44732957
70MP0005000_abnormal_immune_tolerance1.44689192
71MP0003122_maternal_imprinting1.44076783
72MP0002876_abnormal_thyroid_physiology1.43734711
73MP0001501_abnormal_sleep_pattern1.42644090
74MP0003121_genomic_imprinting1.40975776
75MP0004742_abnormal_vestibular_system1.39769542
76MP0001730_embryonic_growth_arrest1.39701030
77MP0004924_abnormal_behavior1.39488798
78MP0005386_behavior/neurological_phenoty1.39488798
79MP0001529_abnormal_vocalization1.38808687
80MP0000313_abnormal_cell_death1.38536696
81MP0004885_abnormal_endolymph1.37431576
82MP0000465_gastrointestinal_hemorrhage1.37066646
83MP0001986_abnormal_taste_sensitivity1.36553288
84MP0005075_abnormal_melanosome_morpholog1.35730415
85MP0002019_abnormal_tumor_incidence1.35085215
86MP0005025_abnormal_response_to1.34805184
87MP0003656_abnormal_erythrocyte_physiolo1.34706526
88MP0005389_reproductive_system_phenotype1.34155976
89MP0002160_abnormal_reproductive_system1.32157604
90MP0000350_abnormal_cell_proliferation1.31367096
91MP0002095_abnormal_skin_pigmentation1.30128724
92MP0004859_abnormal_synaptic_plasticity1.29240609
93MP0002928_abnormal_bile_duct1.28811125
94MP0003183_abnormal_peptide_metabolism1.26983026
95MP0002405_respiratory_system_inflammati1.26911793
96MP0001929_abnormal_gametogenesis1.26452669
97MP0005464_abnormal_platelet_physiology1.26310128
98MP0003879_abnormal_hair_cell1.25996420
99MP0002734_abnormal_mechanical_nocicepti1.23315255
100MP0005387_immune_system_phenotype1.22645598
101MP0001790_abnormal_immune_system1.22645598
102MP0000569_abnormal_digit_pigmentation1.20775261
103MP0002210_abnormal_sex_determination1.18087360
104MP0001919_abnormal_reproductive_system1.17567251
105MP0009278_abnormal_bone_marrow1.17131789
106MP0001485_abnormal_pinna_reflex1.14924482
107MP0003786_premature_aging1.14019722
108MP0000778_abnormal_nervous_system1.13544786
109MP0005167_abnormal_blood-brain_barrier1.12583460
110MP0001853_heart_inflammation1.12484128
111MP0000358_abnormal_cell_content/1.12197888
112MP0002751_abnormal_autonomic_nervous1.10984860
113MP0009764_decreased_sensitivity_to1.10247688
114MP0003866_abnormal_defecation1.09472601
115MP0001440_abnormal_grooming_behavior1.07399903
116MP0006276_abnormal_autonomic_nervous1.06490962
117MP0006292_abnormal_olfactory_placode1.05968219
118MP0003698_abnormal_male_reproductive1.05857789
119MP0000631_abnormal_neuroendocrine_gland1.05726169
120MP0001502_abnormal_circadian_rhythm1.04522946
121MP0005083_abnormal_biliary_tract1.03591735
122MP0000858_altered_metastatic_potential1.01515975
123* MP0002080_prenatal_lethality1.00909933
124MP0000230_abnormal_systemic_arterial0.99723077
125MP0006036_abnormal_mitochondrial_physio0.96966951
126MP0003011_delayed_dark_adaptation0.95618657
127MP0002148_abnormal_hypersensitivity_rea0.95203309
128MP0001145_abnormal_male_reproductive0.93704006
129MP0002419_abnormal_innate_immunity0.93286764
130MP0001697_abnormal_embryo_size0.92812715
131MP0004233_abnormal_muscle_weight0.90771236
132MP0003137_abnormal_impulse_conducting0.90760579
133MP0002933_joint_inflammation0.90426691
134MP0005253_abnormal_eye_physiology0.90171116
135MP0002882_abnormal_neuron_morphology0.89574314
136MP0005195_abnormal_posterior_eye0.85518338
137MP0005084_abnormal_gallbladder_morpholo0.85367408
138MP0010386_abnormal_urinary_bladder0.85322234
139MP0003136_yellow_coat_color0.84602145
140MP0003123_paternal_imprinting0.82957353
141MP0001963_abnormal_hearing_physiology0.81803368
142MP0002752_abnormal_somatic_nervous0.81518340
143MP0001873_stomach_inflammation0.81365405
144MP0000427_abnormal_hair_cycle0.81254856
145MP0003646_muscle_fatigue0.80850736
146MP0002184_abnormal_innervation0.80470331
147MP0002089_abnormal_postnatal_growth/wei0.80209129
148MP0000955_abnormal_spinal_cord0.79901890
149MP0002138_abnormal_hepatobiliary_system0.79799436
150MP0010030_abnormal_orbit_morphology0.79314888
151MP0000026_abnormal_inner_ear0.78265997
152MP0002938_white_spotting0.78052688
153MP0005448_abnormal_energy_balance0.77440494
154MP0001348_abnormal_lacrimal_gland0.77008227
155MP0002735_abnormal_chemical_nociception0.76316024
156MP0002066_abnormal_motor_capabilities/c0.75528028
157MP0003303_peritoneal_inflammation0.74594682
158MP0002282_abnormal_trachea_morphology0.74447715
159MP0001845_abnormal_inflammatory_respons0.74441587
160MP0003172_abnormal_lysosome_physiology0.74219879
161MP0002102_abnormal_ear_morphology0.74208657
162MP0002161_abnormal_fertility/fecundity0.73933390
163MP0000653_abnormal_sex_gland0.73333592
164MP0008961_abnormal_basal_metabolism0.72158579
165MP0003633_abnormal_nervous_system0.71451207
166MP0001324_abnormal_eye_pigmentation0.71178302
167MP0003943_abnormal_hepatobiliary_system0.70571176
168MP0002693_abnormal_pancreas_physiology0.70537370
169MP0005171_absent_coat_pigmentation0.70517753
170MP0000750_abnormal_muscle_regeneration0.70353424
171MP0002229_neurodegeneration0.69847390
172MP0002132_abnormal_respiratory_system0.68609697
173MP0001663_abnormal_digestive_system0.67704428
174MP0003221_abnormal_cardiomyocyte_apopto0.66351919
175MP0002736_abnormal_nociception_after0.66251587
176MP0006035_abnormal_mitochondrial_morpho0.66128794

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.20073768
2Abnormality of alanine metabolism (HP:0010916)4.20073768
3Hyperalaninemia (HP:0003348)4.20073768
4Pancreatic cysts (HP:0001737)4.05696613
5Congenital stationary night blindness (HP:0007642)4.04722846
6Hyperventilation (HP:0002883)3.93294345
7Molar tooth sign on MRI (HP:0002419)3.92192178
8Abnormality of midbrain morphology (HP:0002418)3.92192178
9Aplastic anemia (HP:0001915)3.87972896
10Genetic anticipation (HP:0003743)3.82434452
11Type II lissencephaly (HP:0007260)3.66267305
12Pancreatic fibrosis (HP:0100732)3.57395260
13Inability to walk (HP:0002540)3.53882026
14Recurrent bronchitis (HP:0002837)3.36941131
15Thrombocytosis (HP:0001894)3.33859770
16True hermaphroditism (HP:0010459)3.33552588
17Progressive cerebellar ataxia (HP:0002073)3.33097135
18Abnormal number of erythroid precursors (HP:0012131)3.28915221
19Nasal polyposis (HP:0100582)3.26075586
20Clumsiness (HP:0002312)3.24227011
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20753560
22Abnormality of the anterior horn cell (HP:0006802)3.18634100
23Degeneration of anterior horn cells (HP:0002398)3.18634100
24Nephronophthisis (HP:0000090)3.18406947
25Abnormality of cells of the erythroid lineage (HP:0012130)3.13106645
26Protruding tongue (HP:0010808)3.09007556
27Attenuation of retinal blood vessels (HP:0007843)3.01096568
28Elevated erythrocyte sedimentation rate (HP:0003565)2.96676958
29IgM deficiency (HP:0002850)2.92129099
30Reticulocytopenia (HP:0001896)2.90095016
31Abnormality of the nasal mucosa (HP:0000433)2.88134931
32Pendular nystagmus (HP:0012043)2.82319358
33Breast hypoplasia (HP:0003187)2.71835063
34Progressive inability to walk (HP:0002505)2.70531589
3511 pairs of ribs (HP:0000878)2.69076076
36Abolished electroretinogram (ERG) (HP:0000550)2.68244569
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.66356635
38Cystic liver disease (HP:0006706)2.63804249
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.63554301
40Hypoplasia of the capital femoral epiphysis (HP:0003090)2.61072672
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58086549
42Patellar aplasia (HP:0006443)2.57726864
43Severe muscular hypotonia (HP:0006829)2.57541191
44Abnormality of the renal medulla (HP:0100957)2.56674168
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56189612
46Agammaglobulinemia (HP:0004432)2.55830966
47Increased neuronal autofluorescent lipopigment (HP:0002074)2.54086277
48Abnormal rod and cone electroretinograms (HP:0008323)2.51420222
49Mesangial abnormality (HP:0001966)2.49548761
50Myositis (HP:0100614)2.48240467
51Type I transferrin isoform profile (HP:0003642)2.47119771
52Chronic otitis media (HP:0000389)2.46989389
53Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46016164
54Large eyes (HP:0001090)2.41584140
55Abnormality of binocular vision (HP:0011514)2.38276251
56Diplopia (HP:0000651)2.38276251
57Myelodysplasia (HP:0002863)2.35925724
58Visual hallucinations (HP:0002367)2.35343890
59Birth length less than 3rd percentile (HP:0003561)2.35067701
60Decreased circulating renin level (HP:0003351)2.35022147
61Cerebellar dysplasia (HP:0007033)2.34784430
62Medial flaring of the eyebrow (HP:0010747)2.34453275
63Retinal dysplasia (HP:0007973)2.34032257
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33574064
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33574064
66Medulloblastoma (HP:0002885)2.32993338
67Chronic hepatic failure (HP:0100626)2.32777501
68Chorioretinal atrophy (HP:0000533)2.32672670
69Muscle fiber atrophy (HP:0100295)2.32214019
70Petechiae (HP:0000967)2.29839349
71Optic nerve coloboma (HP:0000588)2.29579570
72Keratoconus (HP:0000563)2.28936586
73Increased corneal curvature (HP:0100692)2.28936586
74Gaze-evoked nystagmus (HP:0000640)2.28568045
75Large for gestational age (HP:0001520)2.27214064
76Recurrent abscess formation (HP:0002722)2.26744087
77Decreased central vision (HP:0007663)2.26593777
78Aplasia/Hypoplasia of the patella (HP:0006498)2.24643244
79Bronchitis (HP:0012387)2.24228672
80Sclerocornea (HP:0000647)2.24175325
81Lissencephaly (HP:0001339)2.21961844
82Abnormality of the renal cortex (HP:0011035)2.20107844
83Amyotrophic lateral sclerosis (HP:0007354)2.18719517
84Polydipsia (HP:0001959)2.18315324
85Abnormal drinking behavior (HP:0030082)2.18315324
86Congenital, generalized hypertrichosis (HP:0004540)2.18272889
87Absent speech (HP:0001344)2.17660779
88Panhypogammaglobulinemia (HP:0003139)2.17480011
89Bony spicule pigmentary retinopathy (HP:0007737)2.15734888
90Hyperacusis (HP:0010780)2.15548536
91Agitation (HP:0000713)2.15300802
92Broad-based gait (HP:0002136)2.14792593
93Microretrognathia (HP:0000308)2.14753492
94Cellulitis (HP:0100658)2.13821211
95Hypoplasia of the pons (HP:0012110)2.13469875
96Type 2 muscle fiber atrophy (HP:0003554)2.12613380
97Aplasia/Hypoplasia of the uvula (HP:0010293)2.12441439
98Absent epiphyses (HP:0010577)2.11051574
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11051574
100Abnormality of the pons (HP:0007361)2.10815368
101Gait imbalance (HP:0002141)2.09996000
102Tubular atrophy (HP:0000092)2.08458483
103Febrile seizures (HP:0002373)2.07880289
104Concave nail (HP:0001598)2.06862419
105Chronic sinusitis (HP:0011109)2.06682312
106Abnormal glycosylation (HP:0012345)2.04567836
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04567836
108Abnormal protein N-linked glycosylation (HP:0012347)2.04567836
109Abnormal protein glycosylation (HP:0012346)2.04567836
110Aplasia/Hypoplasia of the tibia (HP:0005772)2.02801008
111Pachygyria (HP:0001302)2.01840053
112Lymphoma (HP:0002665)2.01531609
113Progressive microcephaly (HP:0000253)1.99751099
114Furrowed tongue (HP:0000221)1.99600968
115Partial agenesis of the corpus callosum (HP:0001338)1.99300763
116Poor head control (HP:0002421)1.98888259
117Meningitis (HP:0001287)1.96852569
118Oral leukoplakia (HP:0002745)1.96716637
119Papilloma (HP:0012740)1.95777299
120Verrucae (HP:0200043)1.95777299
121Severe visual impairment (HP:0001141)1.95466681
122Reduced antithrombin III activity (HP:0001976)1.94343977
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.94143121
124Bulbous nose (HP:0000414)1.92939063
125B lymphocytopenia (HP:0010976)1.92730887
126Abnormality of B cell number (HP:0010975)1.92730887
127Recurrent otitis media (HP:0000403)1.92730336
128Abnormality of the ileum (HP:0001549)1.91567183
129Carpal bone hypoplasia (HP:0001498)1.91175391
130Hepatocellular necrosis (HP:0001404)1.90036005
131Increased cerebral lipofuscin (HP:0011813)1.89918293
132Hemiparesis (HP:0001269)1.89749419
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.88371688
134Focal seizures (HP:0007359)1.88222424
135Congenital hepatic fibrosis (HP:0002612)1.88137252
136Agnosia (HP:0010524)1.87755436
137Bone marrow hypocellularity (HP:0005528)1.87695127
138Pallor (HP:0000980)1.87250425
139Lymphopenia (HP:0001888)1.86911886
140Selective tooth agenesis (HP:0001592)1.86628881
141Increased nuchal translucency (HP:0010880)1.85998172
142Spinal canal stenosis (HP:0003416)1.85356105
143Prolonged bleeding time (HP:0003010)1.85093190
144Congenital primary aphakia (HP:0007707)1.84678094
145Anencephaly (HP:0002323)1.83613837
146Abnormality of the intervertebral disk (HP:0005108)1.83547908
147Colon cancer (HP:0003003)1.83261609
148Stomatitis (HP:0010280)1.82675760
149Meckel diverticulum (HP:0002245)1.82451705
150Amaurosis fugax (HP:0100576)1.82442516
151Short femoral neck (HP:0100864)1.81768873
152Impaired smooth pursuit (HP:0007772)1.81069423
153Recurrent viral infections (HP:0004429)1.79529582
154Focal motor seizures (HP:0011153)1.78881439
155Epileptic encephalopathy (HP:0200134)1.78249211
156Opisthotonus (HP:0002179)1.74806341
157Recurrent bacterial skin infections (HP:0005406)1.74660891
158Dyskinesia (HP:0100660)1.74286381
159Radial bowing (HP:0002986)1.73527500
160Recurrent sinusitis (HP:0011108)1.73491721
161Pancytopenia (HP:0001876)1.72831098
162Neutropenia (HP:0001875)1.72636820
163IgG deficiency (HP:0004315)1.72190123
164Abnormality of T cell physiology (HP:0011840)1.71821445
165Small hand (HP:0200055)1.71678474
166Papilledema (HP:0001085)1.70583606
167Male pseudohermaphroditism (HP:0000037)1.70374289
168Nephrogenic diabetes insipidus (HP:0009806)1.69837976
169Congenital sensorineural hearing impairment (HP:0008527)1.69640091
170Absent/shortened dynein arms (HP:0200106)1.69028558
171Dynein arm defect of respiratory motile cilia (HP:0012255)1.69028558
172Absent thumb (HP:0009777)1.68529059
173Hemiplegia (HP:0002301)1.68183330
174Slender long bone (HP:0003100)1.67458650
175Abnormality of the renal collecting system (HP:0004742)1.66844750
176Abnormality of T cells (HP:0002843)1.66650087
177Abnormality of chromosome stability (HP:0003220)1.66397939
178Fair hair (HP:0002286)1.66231492
179Cerebral hypomyelination (HP:0006808)1.66026156
180Prominent metopic ridge (HP:0005487)1.65923699
181Poikiloderma (HP:0001029)1.65263435
182Abnormal neuron morphology (HP:0012757)1.64778074
183Abnormality of the motor neurons (HP:0002450)1.64778074
184Cutaneous melanoma (HP:0012056)1.64304073
185Exertional dyspnea (HP:0002875)1.63704921
186Recurrent fungal infections (HP:0002841)1.62594421
187Bicuspid aortic valve (HP:0001647)1.61299567
188Abnormality of the carotid arteries (HP:0005344)1.61069102
189Ragged-red muscle fibers (HP:0003200)1.60853881
190Irregular epiphyses (HP:0010582)1.60658175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68282345
2BUB13.92129901
3ADRBK23.64400794
4TLK13.24960869
5BMPR1B3.04944568
6MAP4K12.82024501
7DAPK22.80758288
8SIK32.79515589
9STK162.68960062
10TESK12.61653977
11TESK22.59130999
12CCNB12.59060786
13EIF2AK12.58191137
14MAP3K122.43083680
15TAOK32.41324675
16PASK2.37629278
17BRSK12.28591761
18WNK42.18925437
19GRK12.18763778
20CDC72.16908442
21WEE12.12801899
22ZAK2.04212402
23EIF2AK32.04035786
24ACVR1B2.03181682
25EEF2K1.96970322
26NEK11.93445319
27NEK21.90567485
28CAMKK11.89480477
29TRIB31.87558492
30PINK11.86107546
31ADRBK11.78631278
32BRSK21.73798480
33TGFBR11.59313851
34NME21.55951432
35PIM21.55841654
36KIT1.55445755
37MAP3K101.54382438
38ZAP701.50354377
39MAP3K131.45258772
40BTK1.44864606
41TNK21.41452287
42INSRR1.36443014
43DYRK31.33327912
44LIMK11.32302223
45MAP2K71.32073121
46BLK1.29381362
47CASK1.25819712
48MAP3K41.24313409
49ATR1.20808658
50PTK2B1.19859158
51DAPK11.19633529
52SYK1.19005450
53MAP4K21.18096576
54VRK11.17732566
55TSSK61.16502234
56NTRK21.13894241
57ARAF1.10743403
58NTRK31.10536382
59PRKCG1.09722115
60SCYL21.08904337
61PKN21.06810381
62KDR1.06475732
63TBK11.06288301
64CSF1R1.05490404
65MAP3K111.04815762
66PLK11.04624416
67PAK61.02887208
68CDK191.00138586
69MINK10.99745908
70TXK0.97695631
71DYRK20.97471887
72LRRK20.97182752
73MAP2K60.94185211
74PAK40.92377047
75PRKD20.91734429
76UHMK10.88628087
77FLT30.88544936
78CDK80.87670528
79MAP3K90.87531496
80RPS6KA60.87107656
81PDK30.86356319
82PDK40.86356319
83MAPKAPK30.83257044
84MATK0.81981954
85AURKA0.80746992
86ILK0.80479948
87RPS6KA40.78583586
88SRPK10.77141791
89CAMK10.76499606
90CSNK1A1L0.75628364
91PRKCI0.75089730
92PRKCQ0.73636344
93JAK30.73633148
94CSNK1G30.73622882
95PKN10.72304079
96CSNK1G20.71495379
97WNK30.71464236
98GRK70.70952062
99BRAF0.69998302
100OXSR10.69416416
101STK100.69219073
102NUAK10.68905377
103YES10.68191493
104RPS6KA50.67976983
105PHKG10.67325023
106PHKG20.67325023
107CDK70.66500601
108MAPK150.66481378
109IKBKB0.66120249
110MAP2K40.66083638
111AURKB0.64866948
112TEC0.64855246
113TIE10.63295723
114MAPKAPK50.62860248
115GRK60.62136115
116STK110.61812989
117MKNK10.60785584
118ERBB30.59551915
119PRKCH0.59405960
120MYLK0.58685226
121MAPK130.57885050
122CSNK1G10.57120285
123KSR10.55783603
124ERN10.55766260
125LYN0.55302484
126STK380.55261936
127WNK10.54431985
128TAOK20.54394386
129MAP2K10.54298208
130FES0.54173011
131DYRK1B0.52908512
132TYRO30.52147213
133MAPK120.51301204
134NEK90.49445077
135MAP2K30.49303757
136SGK2230.49198313
137SGK4940.49198313
138TYK20.48901491
139GRK50.48827349
140PAK30.48816312
141CAMK2A0.48705824
142PRKCZ0.47837580
143CDK40.47289670
144BCKDK0.47284557
145CHEK10.45765860
146PAK10.45263118
147MAP3K70.44655546
148CHEK20.44324164
149CAMK40.44257461
150MARK10.43926090
151CDK180.43360449
152IKBKE0.42836553
153ITK0.42172279
154PLK30.41695797
155RPS6KB20.41679670
156LCK0.41319944
157IRAK40.40753045
158MAP2K20.39656105
159RAF10.39523561
160CAMKK20.37664920
161PRKACA0.36667794
162MAPK40.36540712
163PNCK0.36486580
164MAPK110.35387503
165MARK20.35053396
166CDK11A0.33822102
167RPS6KA20.33303577
168MAPKAPK20.32898449
169PIM10.32795921
170SIK20.30795509

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.88592646
2Mismatch repair_Homo sapiens_hsa034304.15760699
3Base excision repair_Homo sapiens_hsa034103.39355650
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.25441801
5Proteasome_Homo sapiens_hsa030503.25265093
6Nicotine addiction_Homo sapiens_hsa050332.93634568
7Spliceosome_Homo sapiens_hsa030402.88235799
8Phototransduction_Homo sapiens_hsa047442.87577332
9Ribosome_Homo sapiens_hsa030102.84539018
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.72767918
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.57613989
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36160139
13Cell cycle_Homo sapiens_hsa041102.34157420
14Morphine addiction_Homo sapiens_hsa050322.33228267
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.32152859
16Homologous recombination_Homo sapiens_hsa034402.30986958
17Nitrogen metabolism_Homo sapiens_hsa009102.29275112
18Pyrimidine metabolism_Homo sapiens_hsa002402.26515106
19Nucleotide excision repair_Homo sapiens_hsa034202.25831642
20RNA polymerase_Homo sapiens_hsa030202.25027360
21RNA transport_Homo sapiens_hsa030132.19235937
22Linoleic acid metabolism_Homo sapiens_hsa005912.18982233
23Selenocompound metabolism_Homo sapiens_hsa004502.15824526
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15362576
25Primary immunodeficiency_Homo sapiens_hsa053401.83697848
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83357298
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79970428
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77365694
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.70021059
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67110404
31GABAergic synapse_Homo sapiens_hsa047271.61188335
32Butanoate metabolism_Homo sapiens_hsa006501.55170872
33Fanconi anemia pathway_Homo sapiens_hsa034601.54517298
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.54383432
35Tryptophan metabolism_Homo sapiens_hsa003801.48419289
36Taste transduction_Homo sapiens_hsa047421.48024147
37Basal transcription factors_Homo sapiens_hsa030221.46267820
38Circadian entrainment_Homo sapiens_hsa047131.46238939
39RNA degradation_Homo sapiens_hsa030181.42963652
40Epstein-Barr virus infection_Homo sapiens_hsa051691.42456828
41Glutamatergic synapse_Homo sapiens_hsa047241.41446692
42Non-homologous end-joining_Homo sapiens_hsa034501.40541977
43Oxidative phosphorylation_Homo sapiens_hsa001901.40476018
44Ether lipid metabolism_Homo sapiens_hsa005651.38662367
45N-Glycan biosynthesis_Homo sapiens_hsa005101.34240872
46Insulin secretion_Homo sapiens_hsa049111.33425834
47ABC transporters_Homo sapiens_hsa020101.33185971
48mRNA surveillance pathway_Homo sapiens_hsa030151.29121719
49Olfactory transduction_Homo sapiens_hsa047401.24691306
50Antigen processing and presentation_Homo sapiens_hsa046121.24449993
51Calcium signaling pathway_Homo sapiens_hsa040201.23800435
52Serotonergic synapse_Homo sapiens_hsa047261.22456225
53Shigellosis_Homo sapiens_hsa051311.20128480
54Purine metabolism_Homo sapiens_hsa002301.18947573
55B cell receptor signaling pathway_Homo sapiens_hsa046621.17505962
56Cardiac muscle contraction_Homo sapiens_hsa042601.16648889
57Cholinergic synapse_Homo sapiens_hsa047251.13948429
58Herpes simplex infection_Homo sapiens_hsa051681.13556621
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.11732280
60Glycerolipid metabolism_Homo sapiens_hsa005611.11660049
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11169176
62Dopaminergic synapse_Homo sapiens_hsa047281.10536693
63Cocaine addiction_Homo sapiens_hsa050301.08443110
64Oocyte meiosis_Homo sapiens_hsa041140.98337237
65Oxytocin signaling pathway_Homo sapiens_hsa049210.97860710
66Legionellosis_Homo sapiens_hsa051340.96783060
67Salivary secretion_Homo sapiens_hsa049700.96435354
68Ovarian steroidogenesis_Homo sapiens_hsa049130.95208486
69Synaptic vesicle cycle_Homo sapiens_hsa047210.95198086
70Measles_Homo sapiens_hsa051620.94957457
71Gastric acid secretion_Homo sapiens_hsa049710.92968398
72Pentose phosphate pathway_Homo sapiens_hsa000300.92565706
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92463610
74p53 signaling pathway_Homo sapiens_hsa041150.91524082
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89933001
76Notch signaling pathway_Homo sapiens_hsa043300.88761967
77HTLV-I infection_Homo sapiens_hsa051660.88333382
78One carbon pool by folate_Homo sapiens_hsa006700.86732605
79Leishmaniasis_Homo sapiens_hsa051400.86172963
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84499502
81Colorectal cancer_Homo sapiens_hsa052100.82629598
82Hepatitis B_Homo sapiens_hsa051610.80988263
83Parkinsons disease_Homo sapiens_hsa050120.79826484
84Acute myeloid leukemia_Homo sapiens_hsa052210.78512696
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77260650
86Arachidonic acid metabolism_Homo sapiens_hsa005900.77230816
87Apoptosis_Homo sapiens_hsa042100.77067977
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.76675816
89Viral carcinogenesis_Homo sapiens_hsa052030.75831482
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73992978
91Chronic myeloid leukemia_Homo sapiens_hsa052200.73661486
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.73538422
93Alzheimers disease_Homo sapiens_hsa050100.72731351
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72696032
95Huntingtons disease_Homo sapiens_hsa050160.72617154
96MAPK signaling pathway_Homo sapiens_hsa040100.71385071
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71254838
98Thyroid cancer_Homo sapiens_hsa052160.70414616
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70051222
100Viral myocarditis_Homo sapiens_hsa054160.69822602
101T cell receptor signaling pathway_Homo sapiens_hsa046600.69685250
102Sulfur relay system_Homo sapiens_hsa041220.69225390
103Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69141034
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.69018657
105Long-term depression_Homo sapiens_hsa047300.67744709
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67723594
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66507944
108Graft-versus-host disease_Homo sapiens_hsa053320.66318536
109Protein export_Homo sapiens_hsa030600.66082619
110Regulation of autophagy_Homo sapiens_hsa041400.66009981
111Hematopoietic cell lineage_Homo sapiens_hsa046400.65305281
112Dorso-ventral axis formation_Homo sapiens_hsa043200.64753233
113cAMP signaling pathway_Homo sapiens_hsa040240.64416007
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.64385901
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64199966
116Amphetamine addiction_Homo sapiens_hsa050310.63244213
117Other glycan degradation_Homo sapiens_hsa005110.62764261
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.61067700
119Non-small cell lung cancer_Homo sapiens_hsa052230.59932379
120Influenza A_Homo sapiens_hsa051640.58337305
121Collecting duct acid secretion_Homo sapiens_hsa049660.57707214
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56611312
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56289942
124Peroxisome_Homo sapiens_hsa041460.55805602
125Biosynthesis of amino acids_Homo sapiens_hsa012300.54858542
126Caffeine metabolism_Homo sapiens_hsa002320.54557077
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54503056
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54373797
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54345549
130Galactose metabolism_Homo sapiens_hsa000520.51882253
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.51111223
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51005104
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.50557316
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.49937045
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49666555
136Axon guidance_Homo sapiens_hsa043600.49154484
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48677485
138Allograft rejection_Homo sapiens_hsa053300.47907931
139Pancreatic cancer_Homo sapiens_hsa052120.47726812
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.45570641
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45567783
142VEGF signaling pathway_Homo sapiens_hsa043700.45212269
143Autoimmune thyroid disease_Homo sapiens_hsa053200.44750974
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43691979
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43219594
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.39651993
147Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39387994
148Ras signaling pathway_Homo sapiens_hsa040140.39175109
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38589022
150Carbon metabolism_Homo sapiens_hsa012000.38217371
151Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37668635
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37589737
1532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.37215456
154Osteoclast differentiation_Homo sapiens_hsa043800.34771870
155HIF-1 signaling pathway_Homo sapiens_hsa040660.34672655
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34620510
157Type I diabetes mellitus_Homo sapiens_hsa049400.34441851
158Type II diabetes mellitus_Homo sapiens_hsa049300.34294952
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33171823
160Platelet activation_Homo sapiens_hsa046110.33156224
161Bladder cancer_Homo sapiens_hsa052190.32786950
162Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32609955
163Phagosome_Homo sapiens_hsa041450.32368496
164Asthma_Homo sapiens_hsa053100.32336774
165Alcoholism_Homo sapiens_hsa050340.31990733
166Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30758976
167Salmonella infection_Homo sapiens_hsa051320.30636169
168Pyruvate metabolism_Homo sapiens_hsa006200.28637118
169Tuberculosis_Homo sapiens_hsa051520.27972368
170Chemical carcinogenesis_Homo sapiens_hsa052040.26535793
171Cyanoamino acid metabolism_Homo sapiens_hsa004600.25028477
172Metabolic pathways_Homo sapiens_hsa011000.24707928

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