AP1G1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPII vesicle coating (GO:0048208)4.73095705
2cytoplasmic mRNA processing body assembly (GO:0033962)3.62419830
3histone H3-K36 demethylation (GO:0070544)3.61079948
4regulation of histone H3-K27 methylation (GO:0061085)3.53505888
5dicarboxylic acid biosynthetic process (GO:0043650)3.45062354
6pre-miRNA processing (GO:0031054)3.43790822
7embryonic process involved in female pregnancy (GO:0060136)3.32760527
8regulation of fatty acid beta-oxidation (GO:0031998)3.31911050
9alpha-linolenic acid metabolic process (GO:0036109)3.30149331
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29348969
11hippo signaling (GO:0035329)3.26361457
12pore complex assembly (GO:0046931)3.23933804
13NLS-bearing protein import into nucleus (GO:0006607)3.20074740
14desmosome organization (GO:0002934)3.18726254
15regulation of cholesterol homeostasis (GO:2000188)3.16195809
16intestinal epithelial cell development (GO:0060576)3.14714676
17iron ion import (GO:0097286)3.10611109
18positive regulation of fatty acid beta-oxidation (GO:0032000)3.08090185
19glucocorticoid receptor signaling pathway (GO:0042921)3.07548963
20positive regulation of macroautophagy (GO:0016239)3.05751324
21urea metabolic process (GO:0019627)3.04444134
22urea cycle (GO:0000050)3.04444134
23macroautophagy (GO:0016236)3.03835590
24nuclear pore complex assembly (GO:0051292)3.03226959
25lysine catabolic process (GO:0006554)3.00978873
26lysine metabolic process (GO:0006553)3.00978873
27histone lysine demethylation (GO:0070076)2.97419164
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96486657
29positive regulation of histone deacetylation (GO:0031065)2.92699697
30insulin-like growth factor receptor signaling pathway (GO:0048009)2.90740997
31nuclear pore organization (GO:0006999)2.90154166
32mitotic sister chromatid cohesion (GO:0007064)2.87743992
33histone demethylation (GO:0016577)2.86248755
34regulation of RNA export from nucleus (GO:0046831)2.84488250
35Golgi to endosome transport (GO:0006895)2.84261633
36regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.82160077
37embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79566417
38growth hormone receptor signaling pathway (GO:0060396)2.78220090
39epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75452551
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.74800099
41homocysteine metabolic process (GO:0050667)2.71828486
42protein localization to microtubule (GO:0035372)2.71751382
43serine family amino acid catabolic process (GO:0009071)2.71682606
44COPI coating of Golgi vesicle (GO:0048205)2.70226668
45Golgi transport vesicle coating (GO:0048200)2.70226668
46complement activation, alternative pathway (GO:0006957)2.67839772
47embryonic camera-type eye morphogenesis (GO:0048596)2.66754767
48response to laminar fluid shear stress (GO:0034616)2.65658059
49Golgi organization (GO:0007030)2.64780522
50peptidyl-lysine dimethylation (GO:0018027)2.64693913
51regulation of clathrin-mediated endocytosis (GO:2000369)2.62429577
52regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.58512971
53regulation of nucleobase-containing compound transport (GO:0032239)2.58035836
54peptidyl-glutamic acid carboxylation (GO:0017187)2.57813928
55protein carboxylation (GO:0018214)2.57813928
56regulation of glucose import in response to insulin stimulus (GO:2001273)2.57545858
57ER overload response (GO:0006983)2.57524697
58cellular response to ethanol (GO:0071361)2.57392109
59kynurenine metabolic process (GO:0070189)2.56946309
60positive regulation of cellular response to insulin stimulus (GO:1900078)2.56771229
61corticosteroid receptor signaling pathway (GO:0031958)2.56599664
62hypotonic response (GO:0006971)2.56301015
63regulation of protein activation cascade (GO:2000257)2.54118773
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.53547872
65phospholipid homeostasis (GO:0055091)2.52538465
66nitrogen cycle metabolic process (GO:0071941)2.52321091
67low-density lipoprotein particle clearance (GO:0034383)2.52140147
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.50765108
69midgut development (GO:0007494)2.50702869
70adherens junction assembly (GO:0034333)2.46818540
71cell adhesion mediated by integrin (GO:0033627)2.46723883
72regulation of complement activation (GO:0030449)2.46309971
73negative regulation of fatty acid transport (GO:2000192)2.46162793
74hepatocyte apoptotic process (GO:0097284)2.45949933
75positive regulation of SMAD protein import into nucleus (GO:0060391)2.45840638
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.45729982
77negative regulation of cell killing (GO:0031342)2.45729982
78endoplasmic reticulum organization (GO:0007029)2.44802048
79drug transmembrane transport (GO:0006855)2.44549436
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.44369148
81cysteine metabolic process (GO:0006534)2.44088553
82negative regulation of sterol transport (GO:0032372)2.44048534
83negative regulation of cholesterol transport (GO:0032375)2.44048534
84protein dealkylation (GO:0008214)2.43402969
85protein demethylation (GO:0006482)2.43402969
86protein localization to endosome (GO:0036010)2.43224684
87glutamate metabolic process (GO:0006536)2.42791360
88peptidyl-threonine modification (GO:0018210)2.42505182
89apoptotic cell clearance (GO:0043277)2.41478048
90positive regulation of lipid catabolic process (GO:0050996)2.40371889
91dosage compensation (GO:0007549)2.40127784
92activation of Rac GTPase activity (GO:0032863)2.39869389
93negative regulation of lipid transport (GO:0032369)2.39579903
94indole-containing compound catabolic process (GO:0042436)2.39409165
95indolalkylamine catabolic process (GO:0046218)2.39409165
96tryptophan catabolic process (GO:0006569)2.39409165
97cell-substrate junction assembly (GO:0007044)2.38941517
98activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38268766
99positive regulation of keratinocyte differentiation (GO:0045618)2.37734737
100L-alpha-amino acid transmembrane transport (GO:1902475)2.37647559
101cellular response to growth hormone stimulus (GO:0071378)2.37282721
102germ cell migration (GO:0008354)2.36925105
103protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.36700131
104urate metabolic process (GO:0046415)2.36565015
105regulation of protein polyubiquitination (GO:1902914)2.36092459
106peptidyl-threonine phosphorylation (GO:0018107)2.35379533
107skin morphogenesis (GO:0043589)2.34862944
108regulation of water loss via skin (GO:0033561)2.34726101
109regulation of ARF protein signal transduction (GO:0032012)2.34528402
110fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.33233496
111aromatic amino acid family catabolic process (GO:0009074)2.32078550
112sulfur amino acid catabolic process (GO:0000098)2.31877736
1132-oxoglutarate metabolic process (GO:0006103)2.31779827
114regulation of translational termination (GO:0006449)2.31395208
115negative regulation of fibrinolysis (GO:0051918)2.31385484
116bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31376071
117fatty acid transmembrane transport (GO:1902001)2.31160883
118negative regulation of NF-kappaB import into nucleus (GO:0042347)2.30784604
119positive regulation of insulin receptor signaling pathway (GO:0046628)2.30674029
120negative regulation of cell size (GO:0045792)2.29825216
121protein targeting to Golgi (GO:0000042)2.29138326
122gastrulation with mouth forming second (GO:0001702)2.28972303
123positive regulation of hormone biosynthetic process (GO:0046886)2.28218586
124histone H3-K9 demethylation (GO:0033169)2.27362434
125regulation of hippo signaling (GO:0035330)2.27307608
126negative regulation of sodium ion transport (GO:0010766)2.26675318
127embryonic eye morphogenesis (GO:0048048)2.26292472
128retrograde transport, vesicle recycling within Golgi (GO:0000301)2.25557453
129vesicle coating (GO:0006901)2.25329537
130hemidesmosome assembly (GO:0031581)2.24822482
131positive regulation of p38MAPK cascade (GO:1900745)2.24201103
132tryptophan metabolic process (GO:0006568)2.24098374
133positive regulation of nuclease activity (GO:0032075)2.23539337
134surfactant homeostasis (GO:0043129)2.22744424
135carnitine shuttle (GO:0006853)2.21930563
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.21249565
137branching involved in mammary gland duct morphogenesis (GO:0060444)2.21173104
138stress granule assembly (GO:0034063)2.20540982
139establishment of protein localization to Golgi (GO:0072600)2.20364699
140cell-substrate adherens junction assembly (GO:0007045)2.19910533
141focal adhesion assembly (GO:0048041)2.19910533
142regulation of cholesterol storage (GO:0010885)2.19252046
143fibroblast migration (GO:0010761)2.18525660
144RNA stabilization (GO:0043489)2.18264846
145mRNA stabilization (GO:0048255)2.18264846
146negative regulation of DNA repair (GO:0045738)2.17998117
147positive regulation of glycogen biosynthetic process (GO:0045725)2.17450828
148chondrocyte development (GO:0002063)2.17448854
149mannose metabolic process (GO:0006013)2.17096355
150regulation of NFAT protein import into nucleus (GO:0051532)2.16755689
151regulation of transforming growth factor beta2 production (GO:0032909)2.16412722
152ER-nucleus signaling pathway (GO:0006984)2.15422634
153histone H2B ubiquitination (GO:0033523)2.14996279
154regulation of Rac protein signal transduction (GO:0035020)2.14172571
155histone H3-K4 trimethylation (GO:0080182)2.14028975
156membrane protein ectodomain proteolysis (GO:0006509)2.13967861
157apical protein localization (GO:0045176)2.13016587
158negative regulation of protein localization to plasma membrane (GO:1903077)2.11530689
159positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.11313587
160interkinetic nuclear migration (GO:0022027)2.11181771
161trophectodermal cell differentiation (GO:0001829)2.10581783
162endoplasmic reticulum unfolded protein response (GO:0030968)2.10567502
163nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.08778649
164response to epidermal growth factor (GO:0070849)2.07819712
165endocytic recycling (GO:0032456)2.06025125
166establishment of nucleus localization (GO:0040023)2.05577379
167negative regulation of anoikis (GO:2000811)2.04926440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.09897067
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.04164832
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.79628208
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.01600316
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.89888655
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.82454198
7CLOCK_20551151_ChIP-Seq_293T_Human2.77044377
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75159721
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.69280478
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46068757
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.27068744
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15926499
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.00898772
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91374081
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.89564446
16MYC_22102868_ChIP-Seq_BL_Human1.89505701
17FOXA2_19822575_ChIP-Seq_HepG2_Human1.81938162
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.81845713
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79794038
20* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78982105
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75437552
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.74391326
23TCF7_22412390_ChIP-Seq_EML_Mouse1.70617383
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66254894
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65726319
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63037306
27ZNF263_19887448_ChIP-Seq_K562_Human1.62465355
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62430260
29ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62310009
30KDM2B_26808549_Chip-Seq_DND41_Human1.61546294
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59171609
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56836982
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.54817907
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54742596
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51860510
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.51572415
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49948297
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48746985
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.48289406
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.47685861
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47456834
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47344868
43* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.45264595
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.44828053
45* FOXM1_23109430_ChIP-Seq_U2OS_Human1.44748130
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43756978
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43123743
48FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.42169547
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41107241
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40342603
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39710436
52KDM2B_26808549_Chip-Seq_K562_Human1.38972860
53* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37475032
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35859533
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34291663
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34114542
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33501749
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32853301
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32451671
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.32355227
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30528523
62* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30228348
63* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30174373
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29693690
65FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28358756
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27192475
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26953048
68* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26279519
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.25753688
70GATA6_25053715_ChIP-Seq_YYC3_Human1.25614093
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22736863
72FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.21322045
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20878520
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19399039
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19231103
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16846948
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16466373
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15739812
79ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14103682
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13975525
81GATA3_24758297_ChIP-Seq_MCF-7_Human1.13412917
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.12164147
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11804653
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.11606401
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.11102037
86TFEB_21752829_ChIP-Seq_HELA_Human1.10077817
87SOX2_20726797_ChIP-Seq_SW620_Human1.09480513
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09119625
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09119625
90CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08410841
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08208291
92NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08190254
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.06821220
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06742756
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06070491
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06062841
97CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05180782
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04936508
99E2F7_22180533_ChIP-Seq_HELA_Human1.04638056
100TP63_23658742_ChIP-Seq_EP156T_Human1.04582376
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04453817
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04295721
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04026542
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04013895
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03463235
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03354966
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03204393
108TRIM28_21343339_ChIP-Seq_HEK293_Human1.02574644
109HNF4A_19822575_ChIP-Seq_HepG2_Human1.02488412
110ATF3_27146783_Chip-Seq_COLON_Human1.02352078
111* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02146557
112BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02001198
113AHR_22903824_ChIP-Seq_MCF-7_Human1.01565976
114AR_21909140_ChIP-Seq_LNCAP_Human1.01053963
115PU_27001747_Chip-Seq_BMDM_Mouse1.00400583
116CHD1_26751641_Chip-Seq_LNCaP_Human1.00290084
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00267159
118SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00267159
119UBF1/2_26484160_Chip-Seq_HMECs_Human1.00002986
120RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99730958
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.99594490
122BRD4_25478319_ChIP-Seq_HGPS_Human0.99388427
123SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99298918
124RACK7_27058665_Chip-Seq_MCF-7_Human0.99101086
125CREB1_26743006_Chip-Seq_LNCaP_Human0.99058818
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98965822
127ELK3_25401928_ChIP-Seq_HUVEC_Human0.98133416
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.96141033
129* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96123633
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96078479
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95621198
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94846528
133TP53_16413492_ChIP-PET_HCT116_Human0.94665042
134STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93664283
135EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93031767
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92056444
137NCOR1_26117541_ChIP-Seq_K562_Human0.91279539
138POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91167889
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90357588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.19023283
2MP0002139_abnormal_hepatobiliary_system4.15392831
3MP0005360_urolithiasis3.88978770
4MP0010234_abnormal_vibrissa_follicle3.86038703
5MP0008057_abnormal_DNA_replication3.75412352
6MP0005409_darkened_coat_color3.48364245
7MP0000569_abnormal_digit_pigmentation3.43427082
8MP0010352_gastrointestinal_tract_polyps3.24152776
9MP0003252_abnormal_bile_duct3.06384160
10MP0003300_gastrointestinal_ulcer3.03567458
11MP0005365_abnormal_bile_salt2.92192479
12MP0005085_abnormal_gallbladder_physiolo2.88542953
13MP0005076_abnormal_cell_differentiation2.71699348
14MP0002009_preneoplasia2.71259266
15MP0010329_abnormal_lipoprotein_level2.08036458
16MP0002796_impaired_skin_barrier1.96032042
17MP0005248_abnormal_Harderian_gland1.95006051
18MP0002877_abnormal_melanocyte_morpholog1.88112789
19MP0005451_abnormal_body_composition1.87919770
20MP0004264_abnormal_extraembryonic_tissu1.85225152
21MP0009780_abnormal_chondrocyte_physiolo1.84479381
22MP0003453_abnormal_keratinocyte_physiol1.83055744
23MP0002138_abnormal_hepatobiliary_system1.80263028
24MP0000383_abnormal_hair_follicle1.77178939
25MP0003566_abnormal_cell_adhesion1.75945498
26MP0003191_abnormal_cellular_cholesterol1.75349678
27MP0003941_abnormal_skin_development1.68781255
28MP0008961_abnormal_basal_metabolism1.65296748
29MP0009053_abnormal_anal_canal1.62677420
30MP0003303_peritoneal_inflammation1.61668810
31MP0008875_abnormal_xenobiotic_pharmacok1.60207229
32MP0000537_abnormal_urethra_morphology1.56168743
33MP0010307_abnormal_tumor_latency1.52017850
34MP0001849_ear_inflammation1.49145958
35MP0000609_abnormal_liver_physiology1.48308324
36MP0004130_abnormal_muscle_cell1.46319246
37MP0003183_abnormal_peptide_metabolism1.44246008
38MP0001666_abnormal_nutrient_absorption1.42412586
39MP0003045_fibrosis1.39923560
40MP0004782_abnormal_surfactant_physiolog1.37699214
41MP0000377_abnormal_hair_follicle1.37575022
42MP0004185_abnormal_adipocyte_glucose1.35840458
43MP0001216_abnormal_epidermal_layer1.35300010
44MP0002928_abnormal_bile_duct1.34515368
45MP0002060_abnormal_skin_morphology1.34098978
46MP0005501_abnormal_skin_physiology1.33110775
47MP0010368_abnormal_lymphatic_system1.33017923
48MP0000733_abnormal_muscle_development1.30737905
49MP0002098_abnormal_vibrissa_morphology1.28656860
50MP0005621_abnormal_cell_physiology1.27573295
51MP0003091_abnormal_cell_migration1.27550162
52MP0003221_abnormal_cardiomyocyte_apopto1.24907134
53MP0005367_renal/urinary_system_phenotyp1.23385070
54MP0000516_abnormal_urinary_system1.23385070
55MP0005666_abnormal_adipose_tissue1.23278211
56MP0003890_abnormal_embryonic-extraembry1.23084411
57MP0002168_other_aberrant_phenotype1.16898927
58MP0005187_abnormal_penis_morphology1.15925582
59MP0002086_abnormal_extraembryonic_tissu1.15505284
60MP0002166_altered_tumor_susceptibility1.14219377
61MP0003868_abnormal_feces_composition1.13628750
62MP0008260_abnormal_autophagy1.12344945
63MP0002896_abnormal_bone_mineralization1.12291702
64MP0004197_abnormal_fetal_growth/weight/1.12202532
65MP0009278_abnormal_bone_marrow1.11391997
66MP0003828_pulmonary_edema1.10799855
67MP0001915_intracranial_hemorrhage1.10626393
68MP0005332_abnormal_amino_acid1.09804656
69MP0003950_abnormal_plasma_membrane1.05493635
70MP0005623_abnormal_meninges_morphology1.05245619
71MP0002088_abnormal_embryonic_growth/wei1.04059177
72MP0009672_abnormal_birth_weight1.03505950
73MP0000015_abnormal_ear_pigmentation1.03050880
74MP0004019_abnormal_vitamin_homeostasis1.02641128
75MP0005167_abnormal_blood-brain_barrier1.02154158
76MP0003115_abnormal_respiratory_system1.01717978
77MP0002118_abnormal_lipid_homeostasis1.01396786
78MP0003984_embryonic_growth_retardation1.00813642
79MP0005275_abnormal_skin_tensile1.00608313
80MP0009840_abnormal_foam_cell1.00511431
81MP0009703_decreased_birth_body1.00211333
82MP0008438_abnormal_cutaneous_collagen0.99565157
83MP0005310_abnormal_salivary_gland0.99401604
84MP0000627_abnormal_mammary_gland0.98770818
85MP0002971_abnormal_brown_adipose0.98616638
86MP0003656_abnormal_erythrocyte_physiolo0.97939037
87MP0003172_abnormal_lysosome_physiology0.97356589
88MP0005375_adipose_tissue_phenotype0.96493783
89MP0000598_abnormal_liver_morphology0.95259846
90MP0002084_abnormal_developmental_patter0.93038235
91MP0001730_embryonic_growth_arrest0.92636094
92MP0005380_embryogenesis_phenotype0.92547204
93MP0001672_abnormal_embryogenesis/_devel0.92547204
94MP0000427_abnormal_hair_cycle0.92111571
95MP0004272_abnormal_basement_membrane0.91451122
96MP0002089_abnormal_postnatal_growth/wei0.90736598
97MP0005319_abnormal_enzyme/_coenzyme0.89379438
98MP0009643_abnormal_urine_homeostasis0.88790242
99MP0000371_diluted_coat_color0.88325971
100MP0004858_abnormal_nervous_system0.87826802
101MP0005023_abnormal_wound_healing0.87619570
102MP0005384_cellular_phenotype0.86803410
103MP0001851_eye_inflammation0.86094315
104MP0009115_abnormal_fat_cell0.85919420
105MP0000350_abnormal_cell_proliferation0.85593436
106MP0010678_abnormal_skin_adnexa0.85311841
107MP0000003_abnormal_adipose_tissue0.84222451
108MP0002909_abnormal_adrenal_gland0.84186182
109MP0004233_abnormal_muscle_weight0.83393598
110MP0002925_abnormal_cardiovascular_devel0.82790808
111MP0002697_abnormal_eye_size0.80919023
112MP0006054_spinal_hemorrhage0.80203823
113MP0003123_paternal_imprinting0.79392128
114MP0004808_abnormal_hematopoietic_stem0.78868450
115MP0001191_abnormal_skin_condition0.78710807
116MP0002092_abnormal_eye_morphology0.78146674
117MP0005220_abnormal_exocrine_pancreas0.77990472
118MP0003943_abnormal_hepatobiliary_system0.77017006
119MP0001756_abnormal_urination0.75195362
120MP0005670_abnormal_white_adipose0.75118711
121MP0010630_abnormal_cardiac_muscle0.73874350
122MP0000428_abnormal_craniofacial_morphol0.73788599
123MP0002136_abnormal_kidney_physiology0.73474977
124MP0002998_abnormal_bone_remodeling0.72553331
125MP0003763_abnormal_thymus_physiology0.72451385
126MP0005083_abnormal_biliary_tract0.71580299
127MP0002396_abnormal_hematopoietic_system0.71406937
128MP0000465_gastrointestinal_hemorrhage0.70552687
129MP0003283_abnormal_digestive_organ0.69235684
130MP0004947_skin_inflammation0.69012813
131MP0005058_abnormal_lysosome_morphology0.68451293
132MP0010155_abnormal_intestine_physiology0.68225677
133MP0000534_abnormal_ureter_morphology0.67868102
134MP0000858_altered_metastatic_potential0.66374715
135MP0003195_calcinosis0.65832247
136MP0001958_emphysema0.65357663
137MP0000767_abnormal_smooth_muscle0.63915345
138MP0010771_integument_phenotype0.63769590
139* MP0002080_prenatal_lethality0.62950407
140MP0002006_tumorigenesis0.62918607
141MP0002128_abnormal_blood_circulation0.62542606
142MP0000266_abnormal_heart_morphology0.62397412
143MP0001697_abnormal_embryo_size0.62143658
144MP0005334_abnormal_fat_pad0.61091040

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)3.05683928
2Deep venous thrombosis (HP:0002625)3.03885041
3Curly hair (HP:0002212)2.95542699
4Macroorchidism (HP:0000053)2.84644397
5Subacute progressive viral hepatitis (HP:0006572)2.83336285
6Spinal cord lesions (HP:0100561)2.71417796
7Syringomyelia (HP:0003396)2.71417796
8Complement deficiency (HP:0004431)2.68384642
9Intrahepatic cholestasis (HP:0001406)2.63836196
10Termporal pattern (HP:0011008)2.63116239
11Insidious onset (HP:0003587)2.63116239
12Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62033778
13Cerebral aneurysm (HP:0004944)2.60392239
14Esophageal varix (HP:0002040)2.59101968
15Abnormality of the lower motor neuron (HP:0002366)2.45379608
16Hand muscle atrophy (HP:0009130)2.43893333
17Thyroid carcinoma (HP:0002890)2.43828997
18Lymphangioma (HP:0100764)2.43504991
19Deep philtrum (HP:0002002)2.43126116
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.39544514
21Osteolytic defects of the hand bones (HP:0009699)2.39544514
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.38142869
23Arterial tortuosity (HP:0005116)2.37408501
24Xanthomatosis (HP:0000991)2.36659411
25Ankyloglossia (HP:0010296)2.35081098
26Abnormality of the common coagulation pathway (HP:0010990)2.33719927
27Coarse hair (HP:0002208)2.27817226
28Enlarged penis (HP:0000040)2.24359132
29Broad face (HP:0000283)2.22686575
30Shallow orbits (HP:0000586)2.21970249
31Mitral valve prolapse (HP:0001634)2.21505435
32Right ventricular cardiomyopathy (HP:0011663)2.13966581
33Overlapping toe (HP:0001845)2.13562200
34Hematochezia (HP:0002573)2.13321544
35Vascular tortuosity (HP:0004948)2.12390955
36Epidermoid cyst (HP:0200040)2.11901341
37Aortic aneurysm (HP:0004942)2.11320965
38Advanced eruption of teeth (HP:0006288)2.10374616
39Hypobetalipoproteinemia (HP:0003563)2.09045911
40Upper limb amyotrophy (HP:0009129)2.08390466
41Distal upper limb amyotrophy (HP:0007149)2.08390466
42Long toe (HP:0010511)2.07606362
43Sparse lateral eyebrow (HP:0005338)2.07473159
44Spastic diplegia (HP:0001264)2.07405807
45Myocardial infarction (HP:0001658)2.07034237
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06304175
47Dysmetric saccades (HP:0000641)2.05525212
48Aneurysm (HP:0002617)2.04005712
49Volvulus (HP:0002580)2.03571653
50Narrow palate (HP:0000189)2.02415942
51Hyperacusis (HP:0010780)2.01015809
52Heterotopia (HP:0002282)2.00071979
53Pseudobulbar signs (HP:0002200)1.99091853
54Abnormality of complement system (HP:0005339)1.95883272
55Germ cell neoplasia (HP:0100728)1.95074939
56Hypoalphalipoproteinemia (HP:0003233)1.94598594
57Relative macrocephaly (HP:0004482)1.93868650
58Hypolipoproteinemia (HP:0010981)1.92927133
59Back pain (HP:0003418)1.92206708
60Hepatocellular carcinoma (HP:0001402)1.92193886
61Short 4th metacarpal (HP:0010044)1.91800698
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91800698
63Micronodular cirrhosis (HP:0001413)1.91223202
64Elfin facies (HP:0004428)1.91176249
65Astrocytoma (HP:0009592)1.90538627
66Abnormality of the astrocytes (HP:0100707)1.90538627
67Cardiovascular calcification (HP:0011915)1.90419441
68Rectal prolapse (HP:0002035)1.86581108
69Abnormality of oral frenula (HP:0000190)1.85684619
70Thickened calvaria (HP:0002684)1.85556923
71Vascular calcification (HP:0004934)1.84661958
72Low anterior hairline (HP:0000294)1.84609826
73Striae distensae (HP:0001065)1.83773843
74Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81949783
75Abnormality of the distal phalanx of the thumb (HP:0009617)1.81243358
76Transitional cell carcinoma of the bladder (HP:0006740)1.80997721
77Systemic lupus erythematosus (HP:0002725)1.77640822
78Renovascular hypertension (HP:0100817)1.77118428
79Abnormality of sulfur amino acid metabolism (HP:0004339)1.76934224
80Renal cell carcinoma (HP:0005584)1.76732674
81Gastrointestinal carcinoma (HP:0002672)1.76534343
82Malignant gastrointestinal tract tumors (HP:0006749)1.76534343
83Obsessive-compulsive behavior (HP:0000722)1.74364642
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72452522
85Menstrual irregularities (HP:0000858)1.72032787
86Abnormality of the fingertips (HP:0001211)1.71898219
87Thin bony cortex (HP:0002753)1.70559807
88Abnormality of the Achilles tendon (HP:0005109)1.70149378
89Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.69902048
90Mitral stenosis (HP:0001718)1.69536941
91Bladder carcinoma (HP:0002862)1.68901651
92Bladder neoplasm (HP:0009725)1.68901651
93Turricephaly (HP:0000262)1.68748795
94Cubitus valgus (HP:0002967)1.68608498
95Abnormality of the 4th metacarpal (HP:0010012)1.68273461
96Cutis marmorata (HP:0000965)1.67863218
97Gout (HP:0001997)1.67112442
98Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.66248240
99Skull defect (HP:0001362)1.66209855
100Tetraparesis (HP:0002273)1.65655310
101Urethral obstruction (HP:0000796)1.65050402
102Overgrowth (HP:0001548)1.64590849
103Vertebral arch anomaly (HP:0008438)1.64210910
104Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63656104
105Hepatoblastoma (HP:0002884)1.63431066
106Skin nodule (HP:0200036)1.62997034
107Exostoses (HP:0100777)1.62375282
108Genetic anticipation (HP:0003743)1.61796833
109Asymmetry of the thorax (HP:0001555)1.61750055
110Neoplasm of the adrenal cortex (HP:0100641)1.59576403
111Acute myeloid leukemia (HP:0004808)1.59185197
112Focal segmental glomerulosclerosis (HP:0000097)1.58563220
113Fibrous tissue neoplasm (HP:0012316)1.58498300
114Dilatation of the ascending aorta (HP:0005111)1.57789548
115Leiomyosarcoma (HP:0100243)1.57637330
116Uterine leiomyosarcoma (HP:0002891)1.57637330
117Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.57562294
118Protrusio acetabuli (HP:0003179)1.57520981
119Fibroma (HP:0010614)1.57171546
120Testicular neoplasm (HP:0010788)1.57098642
121Increased density of long bones (HP:0006392)1.56935943
122Abnormal foot bone ossification (HP:0010675)1.56810515
123Large earlobe (HP:0009748)1.55961305
124Long eyelashes (HP:0000527)1.55681573
125Upper motor neuron abnormality (HP:0002127)1.55611060
126Flat acetabular roof (HP:0003180)1.55559708
127Lip pit (HP:0100267)1.55189086
128Genu recurvatum (HP:0002816)1.54267812
129Deformed sella turcica (HP:0002681)1.54219593
130Dislocated radial head (HP:0003083)1.53912656
131Papillary thyroid carcinoma (HP:0002895)1.53782081
132Open mouth (HP:0000194)1.53268228
133Increased CSF protein (HP:0002922)1.53137206
134Ependymoma (HP:0002888)1.53032852
135Truncal obesity (HP:0001956)1.52990052
136Disinhibition (HP:0000734)1.52945145
137Biliary tract neoplasm (HP:0100574)1.52899585
138Ketosis (HP:0001946)1.52818230
139Absent frontal sinuses (HP:0002688)1.51464510
140Abnormality of purine metabolism (HP:0004352)1.51099429
141Glomerulosclerosis (HP:0000096)1.49902904
142Short nail (HP:0001799)1.49295017
143Hyperglycinemia (HP:0002154)1.49073944
144Cystic hygroma (HP:0000476)1.48888286
145Neoplasm of the thyroid gland (HP:0100031)1.48857212
146Smooth philtrum (HP:0000319)1.48344911
147Low posterior hairline (HP:0002162)1.47862860
148Subaortic stenosis (HP:0001682)1.47704077
149Abnormality of the left ventricular outflow tract (HP:0011103)1.47704077
150Hyperglycemia (HP:0003074)1.47525733
151Progressive sensorineural hearing impairment (HP:0000408)1.47494618
152Hypercholesterolemia (HP:0003124)1.47033508
153Bowel diverticulosis (HP:0005222)1.46692592
154Abnormality of the gastric mucosa (HP:0004295)1.46664824
155Severe short stature (HP:0003510)1.46599384
156Pheochromocytoma (HP:0002666)1.46561256
157Abnormality of the epiphyses of the hand (HP:0005924)1.45716472
158Urinary glycosaminoglycan excretion (HP:0003541)1.45327812
159Mucopolysacchariduria (HP:0008155)1.45327812
160Abnormality of the nasal septum (HP:0000419)1.45184381
161Hammertoe (HP:0001765)1.43342759
162Interstitial pulmonary disease (HP:0006530)1.42846319
163Thick nail (HP:0001805)1.42331851
164Hypoplasia of dental enamel (HP:0006297)1.42068081
165Septate vagina (HP:0001153)1.40930682
166Natal tooth (HP:0000695)1.39688449
167Slow saccadic eye movements (HP:0000514)1.39080496
168Hyperkalemia (HP:0002153)1.39054142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.38478002
2PKN23.15789675
3CDK122.89172031
4LATS12.73198403
5FRK2.60325396
6CAMK1D2.54990272
7RIPK12.38447796
8CAMK1G2.32971047
9PTK62.28494854
10SIK12.18959838
11STK32.02574099
12PDGFRA1.90630990
13EEF2K1.86301981
14MAP3K101.71019028
15PRPF4B1.64832701
16CDK61.59934529
17ALK1.58416804
18YES11.56466461
19TRPM71.52776804
20MAP3K141.52299539
21SCYL21.49641462
22ERN11.44669408
23FGFR31.39639289
24FGFR41.37717821
25MAP3K91.36744952
26EIF2AK31.34617619
27MAP3K21.34339057
28MTOR1.33612649
29MAP3K61.30056172
30SMG11.30029585
31SGK31.29492874
32BRD41.29399922
33LATS21.29014024
34TTN1.27144996
35PNCK1.26357764
36NEK91.26128163
37RET1.23798642
38PIK3CA1.21404774
39PDGFRB1.19310790
40MST1R1.18887155
41FGFR21.11340599
42NEK61.11337305
43PTK21.11104284
44JAK11.08063242
45KSR21.07649885
46EIF2AK11.03651266
47STK381.01838496
48FER0.99955325
49BMX0.99793186
50RPS6KB20.97445065
51MAP3K70.93127501
52FGFR10.92756408
53PRKD30.92540557
54ICK0.88534376
55NEK10.88488812
56STK100.86634196
57MAP3K130.86145258
58DDR20.85049324
59IRAK30.81890674
60CAMKK10.81290451
61MAP3K40.80294953
62SIK20.78614010
63EPHA30.78420786
64DMPK0.75188846
65SGK20.74918842
66SIK30.74687077
67NLK0.74634533
68EPHA20.74453215
69TAOK10.73331997
70PAK60.72761536
71PRKCH0.72660566
72PAK20.72015668
73STK390.70021289
74MAP2K40.69919709
75JAK20.69426335
76ERBB20.68655737
77RPS6KB10.67619502
78PDPK10.67548932
79CDK40.67252773
80LRRK20.66923006
81GSK3A0.66313832
82EPHB10.65981624
83STK240.65841181
84PRKAA10.65499059
85MAP3K10.65267526
86TAOK30.64843194
87SGK4940.64224910
88SGK2230.64224910
89NEK20.64058770
90BMPR20.63861218
91PAK40.63016368
92KSR10.62715434
93PAK30.61323239
94STK38L0.61089015
95MAPK110.60370372
96TGFBR20.59910852
97TYRO30.59378012
98ACVR1B0.58679170
99WNK10.57439973
100PIK3CG0.56870797
101MELK0.56790711
102EGFR0.56086676
103MARK10.55731800
104BCR0.55612965
105TYK20.55420062
106MAP3K80.55020497
107CSK0.54549222
108CDK90.53916289
109AKT30.53516537
110IRAK10.53495431
111CDC42BPA0.52736068
112MAP3K50.49542688
113MAP3K30.49011150
114PDK40.47452631
115PDK30.47452631
116FLT30.46831611
117ERBB30.46792152
118MET0.45328411
119DAPK20.45293143
120BRSK20.45202712
121CHUK0.44701273
122WNK30.44224718
123CSNK1D0.44140209
124ITK0.43065409
125PRKAA20.42931269
126PDK10.42399540
127INSRR0.41775236
128MARK20.40990230
129MAP2K30.40531330
130STK110.40013303
131HCK0.38619569
132SGK10.37732890
133MAPK100.36803634
134ZAP700.36644770
135CSNK1E0.35727801
136MAPK80.35553379
137PRKD20.35203096
138MAPKAPK30.34683573
139ERBB40.34656589

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.77690404
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47059048
3Arginine biosynthesis_Homo sapiens_hsa002202.11883119
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01834743
5Primary bile acid biosynthesis_Homo sapiens_hsa001201.72342627
6Lysine degradation_Homo sapiens_hsa003101.71615990
7Bile secretion_Homo sapiens_hsa049761.53440751
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46150042
9Complement and coagulation cascades_Homo sapiens_hsa046101.45420605
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43875215
11mTOR signaling pathway_Homo sapiens_hsa041501.41464363
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.39547991
13Endometrial cancer_Homo sapiens_hsa052131.28225733
14Chronic myeloid leukemia_Homo sapiens_hsa052201.25705089
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25203078
16Adherens junction_Homo sapiens_hsa045201.24931033
17Insulin resistance_Homo sapiens_hsa049311.23425251
18Hepatitis C_Homo sapiens_hsa051601.23277293
19Tryptophan metabolism_Homo sapiens_hsa003801.22123170
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19623556
21Type II diabetes mellitus_Homo sapiens_hsa049301.18896328
22Staphylococcus aureus infection_Homo sapiens_hsa051501.14470486
23PPAR signaling pathway_Homo sapiens_hsa033201.14092371
24Fatty acid degradation_Homo sapiens_hsa000711.13089346
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.07702757
26Glioma_Homo sapiens_hsa052141.04421810
27Selenocompound metabolism_Homo sapiens_hsa004501.02149393
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01954726
29Caffeine metabolism_Homo sapiens_hsa002321.00091682
30Proteoglycans in cancer_Homo sapiens_hsa052050.98799010
31Sphingolipid signaling pathway_Homo sapiens_hsa040710.96017519
32Dorso-ventral axis formation_Homo sapiens_hsa043200.95449382
33T cell receptor signaling pathway_Homo sapiens_hsa046600.92770632
34Circadian rhythm_Homo sapiens_hsa047100.92581696
35Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91967848
36Starch and sucrose metabolism_Homo sapiens_hsa005000.90396822
37Pancreatic cancer_Homo sapiens_hsa052120.90314086
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88898074
39GnRH signaling pathway_Homo sapiens_hsa049120.88395112
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87481969
41Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87456262
42Non-small cell lung cancer_Homo sapiens_hsa052230.86870299
43Influenza A_Homo sapiens_hsa051640.86456067
44Focal adhesion_Homo sapiens_hsa045100.86359518
45Colorectal cancer_Homo sapiens_hsa052100.84799148
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84423331
47Glucagon signaling pathway_Homo sapiens_hsa049220.83648681
48Butanoate metabolism_Homo sapiens_hsa006500.82552218
49AMPK signaling pathway_Homo sapiens_hsa041520.82388936
50Insulin signaling pathway_Homo sapiens_hsa049100.82365021
51Fatty acid metabolism_Homo sapiens_hsa012120.82060068
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.81655562
53Small cell lung cancer_Homo sapiens_hsa052220.81385655
54Long-term potentiation_Homo sapiens_hsa047200.81308279
55Measles_Homo sapiens_hsa051620.80685383
56Viral carcinogenesis_Homo sapiens_hsa052030.80343721
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78766950
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78225615
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78029450
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77605797
61Sphingolipid metabolism_Homo sapiens_hsa006000.77585294
62Renal cell carcinoma_Homo sapiens_hsa052110.76625133
63Prostate cancer_Homo sapiens_hsa052150.76605597
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.76527670
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75025949
66MicroRNAs in cancer_Homo sapiens_hsa052060.74767918
67ABC transporters_Homo sapiens_hsa020100.74603425
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73905477
69Estrogen signaling pathway_Homo sapiens_hsa049150.73476604
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73325083
71Amoebiasis_Homo sapiens_hsa051460.72901643
72Hippo signaling pathway_Homo sapiens_hsa043900.71797443
73Tight junction_Homo sapiens_hsa045300.70736134
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.70274133
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70019216
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68936131
77Prolactin signaling pathway_Homo sapiens_hsa049170.67726078
78FoxO signaling pathway_Homo sapiens_hsa040680.67559692
79Other glycan degradation_Homo sapiens_hsa005110.67081917
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.67054940
81Shigellosis_Homo sapiens_hsa051310.66113003
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65217541
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64530415
84Fat digestion and absorption_Homo sapiens_hsa049750.64319515
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63463893
86Acute myeloid leukemia_Homo sapiens_hsa052210.63252839
87Apoptosis_Homo sapiens_hsa042100.63242510
88Endocytosis_Homo sapiens_hsa041440.62795357
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62308739
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.62253279
91Bladder cancer_Homo sapiens_hsa052190.61692741
92B cell receptor signaling pathway_Homo sapiens_hsa046620.60920354
93mRNA surveillance pathway_Homo sapiens_hsa030150.60783243
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59503138
95Vibrio cholerae infection_Homo sapiens_hsa051100.58047934
96Fatty acid biosynthesis_Homo sapiens_hsa000610.57938226
97Thyroid cancer_Homo sapiens_hsa052160.57309436
98Biosynthesis of amino acids_Homo sapiens_hsa012300.57144674
99Notch signaling pathway_Homo sapiens_hsa043300.56441032
100VEGF signaling pathway_Homo sapiens_hsa043700.55982026
101Melanoma_Homo sapiens_hsa052180.55422307
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54686769
103Propanoate metabolism_Homo sapiens_hsa006400.54415803
104Long-term depression_Homo sapiens_hsa047300.53375955
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52865181
106Toxoplasmosis_Homo sapiens_hsa051450.52142005
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51308124
108ErbB signaling pathway_Homo sapiens_hsa040120.51206696
109Thyroid hormone synthesis_Homo sapiens_hsa049180.50329477
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50157814
111Pathways in cancer_Homo sapiens_hsa052000.49943663
112Prion diseases_Homo sapiens_hsa050200.49553241
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49089208
114Osteoclast differentiation_Homo sapiens_hsa043800.48600354
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.48001723
116Platelet activation_Homo sapiens_hsa046110.47675003
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47227114
118Rap1 signaling pathway_Homo sapiens_hsa040150.47081896
119Chemokine signaling pathway_Homo sapiens_hsa040620.47007512
120HIF-1 signaling pathway_Homo sapiens_hsa040660.46806326
121Viral myocarditis_Homo sapiens_hsa054160.46227216
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46134722
123Gap junction_Homo sapiens_hsa045400.46010434
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.45810710
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45473134
126ECM-receptor interaction_Homo sapiens_hsa045120.44548273
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44539011
128Choline metabolism in cancer_Homo sapiens_hsa052310.43668332
129Vitamin digestion and absorption_Homo sapiens_hsa049770.43665339
130Carbon metabolism_Homo sapiens_hsa012000.42864988
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42823951
132Inositol phosphate metabolism_Homo sapiens_hsa005620.42436230
133Glycerolipid metabolism_Homo sapiens_hsa005610.42324692
134TNF signaling pathway_Homo sapiens_hsa046680.42286445
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42085974
136Hepatitis B_Homo sapiens_hsa051610.41405573
137TGF-beta signaling pathway_Homo sapiens_hsa043500.39643415
138beta-Alanine metabolism_Homo sapiens_hsa004100.39494700

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