AOC4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.31935322
2exogenous drug catabolic process (GO:0042738)5.97720660
3drug catabolic process (GO:0042737)5.69377911
4negative regulation of cholesterol transport (GO:0032375)5.04071696
5negative regulation of sterol transport (GO:0032372)5.04071696
6response to pheromone (GO:0019236)4.75171927
7glyoxylate metabolic process (GO:0046487)4.30500408
8oxidative demethylation (GO:0070989)4.14483297
9positive regulation of fatty acid transport (GO:2000193)4.04020982
10indole-containing compound catabolic process (GO:0042436)4.02667691
11indolalkylamine catabolic process (GO:0046218)4.02667691
12tryptophan catabolic process (GO:0006569)4.02667691
13aromatic amino acid family catabolic process (GO:0009074)3.97493843
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.91673264
15L-phenylalanine catabolic process (GO:0006559)3.91673264
16arginine metabolic process (GO:0006525)3.90443492
17cellular ketone body metabolic process (GO:0046950)3.88814833
18intestinal cholesterol absorption (GO:0030299)3.88364622
19positive regulation of icosanoid secretion (GO:0032305)3.85734992
20positive regulation of prostaglandin secretion (GO:0032308)3.78342407
21omega-hydroxylase P450 pathway (GO:0097267)3.75422973
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72096094
23serine family amino acid catabolic process (GO:0009071)3.70503221
24epoxygenase P450 pathway (GO:0019373)3.67668792
25regulation of fibrinolysis (GO:0051917)3.62433187
26regulation of triglyceride catabolic process (GO:0010896)3.58675868
27arginine catabolic process (GO:0006527)3.58222576
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.57905784
29complement activation, alternative pathway (GO:0006957)3.52872069
30S-adenosylmethionine metabolic process (GO:0046500)3.46497275
31negative regulation of fibrinolysis (GO:0051918)3.44916609
32ketone body metabolic process (GO:1902224)3.43105230
33regulation of hexokinase activity (GO:1903299)3.42177315
34regulation of glucokinase activity (GO:0033131)3.42177315
35regulation of protein activation cascade (GO:2000257)3.41270096
36imidazole-containing compound metabolic process (GO:0052803)3.39672490
37pyrimidine nucleobase catabolic process (GO:0006208)3.37177579
38alkaloid metabolic process (GO:0009820)3.37056671
39tryptophan metabolic process (GO:0006568)3.36969015
40blood coagulation, intrinsic pathway (GO:0007597)3.32231420
41high-density lipoprotein particle remodeling (GO:0034375)3.31984965
42ethanol oxidation (GO:0006069)3.28410089
43cysteine metabolic process (GO:0006534)3.27659042
44protein carboxylation (GO:0018214)3.26675861
45peptidyl-glutamic acid carboxylation (GO:0017187)3.26675861
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23732112
47regulation of complement activation (GO:0030449)3.22852437
48synaptic transmission, cholinergic (GO:0007271)3.22737871
49drug metabolic process (GO:0017144)3.22636662
50L-fucose metabolic process (GO:0042354)3.20745092
51L-fucose catabolic process (GO:0042355)3.20745092
52fucose catabolic process (GO:0019317)3.20745092
53regulation of prostaglandin secretion (GO:0032306)3.20200130
54bile acid biosynthetic process (GO:0006699)3.17592550
55triglyceride homeostasis (GO:0070328)3.17581878
56acylglycerol homeostasis (GO:0055090)3.17581878
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.12078981
58L-phenylalanine metabolic process (GO:0006558)3.12078981
59detection of light stimulus involved in sensory perception (GO:0050962)3.11351249
60detection of light stimulus involved in visual perception (GO:0050908)3.11351249
61indolalkylamine metabolic process (GO:0006586)3.11003910
62NAD biosynthetic process (GO:0009435)3.07056083
63kynurenine metabolic process (GO:0070189)3.06834602
64DNA deamination (GO:0045006)3.05975825
65positive regulation of organic acid transport (GO:0032892)3.03973868
66protein-lipid complex remodeling (GO:0034368)3.03646649
67macromolecular complex remodeling (GO:0034367)3.03646649
68plasma lipoprotein particle remodeling (GO:0034369)3.03646649
69sulfation (GO:0051923)3.03174640
70tyrosine metabolic process (GO:0006570)2.98681529
71nucleobase catabolic process (GO:0046113)2.89884947
72reverse cholesterol transport (GO:0043691)2.89549276
73amino-acid betaine metabolic process (GO:0006577)2.87078173
74alpha-amino acid catabolic process (GO:1901606)2.85084731
75aromatic amino acid family metabolic process (GO:0009072)2.82314276
76amine catabolic process (GO:0009310)2.78732783
77cellular biogenic amine catabolic process (GO:0042402)2.78732783
78regulation of icosanoid secretion (GO:0032303)2.75374256
79bile acid metabolic process (GO:0008206)2.74757668
80bile acid and bile salt transport (GO:0015721)2.74104878
81aldehyde catabolic process (GO:0046185)2.73634590
82heme transport (GO:0015886)2.72146587
83cholesterol efflux (GO:0033344)2.72094105
84peptidyl-glutamic acid modification (GO:0018200)2.67979289
85positive regulation of fatty acid beta-oxidation (GO:0032000)2.67125795
86cellular glucuronidation (GO:0052695)2.65601427
87negative regulation of telomere maintenance (GO:0032205)2.62303938
88kidney morphogenesis (GO:0060993)2.61541131
893-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61204426
90purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61204426
91ethanol metabolic process (GO:0006067)2.60874145
92amino acid salvage (GO:0043102)2.60296922
93L-methionine salvage (GO:0071267)2.60296922
94L-methionine biosynthetic process (GO:0071265)2.60296922
95primary amino compound metabolic process (GO:1901160)2.60020996
96negative regulation of astrocyte differentiation (GO:0048712)2.59048678
97regulation of cholesterol esterification (GO:0010872)2.58528530
98indole-containing compound metabolic process (GO:0042430)2.58440056
99uronic acid metabolic process (GO:0006063)2.57793328
100glucuronate metabolic process (GO:0019585)2.57793328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.99816136
2EZH2_22144423_ChIP-Seq_EOC_Human3.54122380
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.14384208
4VDR_22108803_ChIP-Seq_LS180_Human2.75552276
5GBX2_23144817_ChIP-Seq_PC3_Human2.47011926
6EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45380699
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27628826
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.12871217
9ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98507320
10CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87848625
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80037580
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78655689
13IGF1R_20145208_ChIP-Seq_DFB_Human1.71852620
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71111684
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64983525
16ER_23166858_ChIP-Seq_MCF-7_Human1.64198307
17REST_21632747_ChIP-Seq_MESCs_Mouse1.60916669
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58362455
19TAF15_26573619_Chip-Seq_HEK293_Human1.58191007
20FUS_26573619_Chip-Seq_HEK293_Human1.57602872
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.54913785
22BCAT_22108803_ChIP-Seq_LS180_Human1.54563120
23P300_19829295_ChIP-Seq_ESCs_Human1.48883752
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47619136
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47292129
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46492661
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45482463
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.45309785
29TP53_22573176_ChIP-Seq_HFKS_Human1.42344582
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41178501
31TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41178501
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.40665093
33NCOR_22424771_ChIP-Seq_293T_Human1.39933297
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38866501
35AR_20517297_ChIP-Seq_VCAP_Human1.35579417
36AR_25329375_ChIP-Seq_VCAP_Human1.35453445
37IRF1_19129219_ChIP-ChIP_H3396_Human1.34543562
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32072715
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.32072715
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32011486
41GATA3_21878914_ChIP-Seq_MCF-7_Human1.31876130
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.31592781
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.31418743
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28889377
45MYC_19829295_ChIP-Seq_ESCs_Human1.28880290
46HTT_18923047_ChIP-ChIP_STHdh_Human1.28330652
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.28130037
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28041653
49NANOG_20526341_ChIP-Seq_ESCs_Human1.27805481
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27196396
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26576001
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26149556
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25796811
54ERA_21632823_ChIP-Seq_H3396_Human1.25770605
55PPARA_22158963_ChIP-Seq_LIVER_Mouse1.25221452
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23140680
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23022919
58DROSHA_22980978_ChIP-Seq_HELA_Human1.22902117
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.21832604
60STAT3_23295773_ChIP-Seq_U87_Human1.21449833
61TCF4_22108803_ChIP-Seq_LS180_Human1.20562881
62SOX2_19829295_ChIP-Seq_ESCs_Human1.20436959
63NANOG_19829295_ChIP-Seq_ESCs_Human1.20436959
64AR_21572438_ChIP-Seq_LNCaP_Human1.19497341
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19246486
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18613743
67FOXH1_21741376_ChIP-Seq_EPCs_Human1.18336751
68CBP_20019798_ChIP-Seq_JUKART_Human1.17372772
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17372772
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16826472
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16612413
72TCF4_23295773_ChIP-Seq_U87_Human1.16541361
73REST_18959480_ChIP-ChIP_MESCs_Mouse1.16436284
74RNF2_27304074_Chip-Seq_NSC_Mouse1.15508662
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.14479901
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14289497
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14192523
78TAF2_19829295_ChIP-Seq_ESCs_Human1.12683417
79SMAD4_21799915_ChIP-Seq_A2780_Human1.12362441
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12121451
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10713757
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10224826
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.09594807
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.08548253
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.08039107
86EWS_26573619_Chip-Seq_HEK293_Human1.07578067
87P53_21459846_ChIP-Seq_SAOS-2_Human1.07271499
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06139449
89RUNX2_22187159_ChIP-Seq_PCA_Human1.05930974
90FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05893483
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.05622440
92OCT4_20526341_ChIP-Seq_ESCs_Human1.05500341
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05477271
94HOXB7_26014856_ChIP-Seq_BT474_Human1.05422758
95FOXH1_21741376_ChIP-Seq_ESCs_Human1.03007581
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02613859
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02582474
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02578655
99MYC_18940864_ChIP-ChIP_HL60_Human1.02377738
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02205523

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis4.88890250
2MP0002139_abnormal_hepatobiliary_system4.17973924
3MP0008875_abnormal_xenobiotic_pharmacok3.94612084
4MP0005085_abnormal_gallbladder_physiolo3.25042220
5MP0005360_urolithiasis3.04656843
6MP0002102_abnormal_ear_morphology2.95222546
7MP0005365_abnormal_bile_salt2.93086722
8MP0010329_abnormal_lipoprotein_level2.41366916
9MP0002638_abnormal_pupillary_reflex2.30053608
10MP0001968_abnormal_touch/_nociception2.29665781
11MP0005551_abnormal_eye_electrophysiolog2.15455551
12MP0005646_abnormal_pituitary_gland1.96690787
13MP0006292_abnormal_olfactory_placode1.94531565
14MP0002735_abnormal_chemical_nociception1.92174323
15MP0003011_delayed_dark_adaptation1.90295955
16MP0001986_abnormal_taste_sensitivity1.89487456
17MP0004885_abnormal_endolymph1.85414664
18MP0003252_abnormal_bile_duct1.83707643
19MP0003646_muscle_fatigue1.82649640
20MP0002876_abnormal_thyroid_physiology1.80174319
21MP0005332_abnormal_amino_acid1.73677373
22MP0003122_maternal_imprinting1.68757566
23MP0005167_abnormal_blood-brain_barrier1.61767329
24MP0008872_abnormal_physiological_respon1.59609971
25MP0004147_increased_porphyrin_level1.57326365
26MP0009840_abnormal_foam_cell1.55283751
27MP0010386_abnormal_urinary_bladder1.54156789
28MP0004133_heterotaxia1.53158200
29MP0002909_abnormal_adrenal_gland1.50983022
30MP0009745_abnormal_behavioral_response1.50339013
31MP0000566_synostosis1.46625583
32MP0004043_abnormal_pH_regulation1.43895419
33MP0001666_abnormal_nutrient_absorption1.39980958
34MP0005645_abnormal_hypothalamus_physiol1.38166571
35MP0003136_yellow_coat_color1.34520742
36MP0008877_abnormal_DNA_methylation1.32402990
37MP0005448_abnormal_energy_balance1.29404793
38MP0004742_abnormal_vestibular_system1.29323655
39MP0006276_abnormal_autonomic_nervous1.27318936
40MP0004142_abnormal_muscle_tone1.25056364
41MP0004019_abnormal_vitamin_homeostasis1.21372110
42MP0002138_abnormal_hepatobiliary_system1.20964108
43MP0005084_abnormal_gallbladder_morpholo1.19207694
44MP0002938_white_spotting1.18841722
45MP0005253_abnormal_eye_physiology1.17248646
46MP0002118_abnormal_lipid_homeostasis1.14764207
47MP0001485_abnormal_pinna_reflex1.14395032
48MP0002557_abnormal_social/conspecific_i1.14257422
49MP0005410_abnormal_fertilization1.11198732
50MP0000372_irregular_coat_pigmentation1.10595450
51MP0004130_abnormal_muscle_cell1.10038308
52MP0001905_abnormal_dopamine_level1.09485267
53MP0008995_early_reproductive_senescence1.08294233
54MP0003879_abnormal_hair_cell1.07690201
55MP0003638_abnormal_response/metabolism_1.07668280
56MP0002736_abnormal_nociception_after1.06012602
57MP0002272_abnormal_nervous_system1.05165229
58MP0002837_dystrophic_cardiac_calcinosis1.03891540
59MP0002572_abnormal_emotion/affect_behav1.02944870
60MP0001486_abnormal_startle_reflex1.02681785
61MP0005377_hearing/vestibular/ear_phenot1.02255165
62MP0003878_abnormal_ear_physiology1.02255165
63MP0003787_abnormal_imprinting1.01466278
64MP0009379_abnormal_foot_pigmentation1.01407408
65MP0000230_abnormal_systemic_arterial1.00914679
66MP0001501_abnormal_sleep_pattern1.00347281
67MP0002733_abnormal_thermal_nociception1.00113235
68MP0005379_endocrine/exocrine_gland_phen0.98418486
69MP0001764_abnormal_homeostasis0.96363809
70MP0006072_abnormal_retinal_apoptosis0.95190683
71MP0002277_abnormal_respiratory_mucosa0.92598304
72MP0002064_seizures0.91615245
73MP0000026_abnormal_inner_ear0.91191319
74MP0005083_abnormal_biliary_tract0.90695967
75MP0001970_abnormal_pain_threshold0.90386794
76MP0002282_abnormal_trachea_morphology0.90074646
77MP0005386_behavior/neurological_phenoty0.87639855
78MP0004924_abnormal_behavior0.87639855
79MP0009643_abnormal_urine_homeostasis0.86248617
80MP0005670_abnormal_white_adipose0.85257646
81MP0003880_abnormal_central_pattern0.83974731
82MP0008775_abnormal_heart_ventricle0.82960392
83MP0005423_abnormal_somatic_nervous0.82026656
84MP0000427_abnormal_hair_cycle0.82002577
85MP0005195_abnormal_posterior_eye0.78117495
86MP0002067_abnormal_sensory_capabilities0.77808978
87MP0001984_abnormal_olfaction0.77688924
88MP0002063_abnormal_learning/memory/cond0.77245227
89MP0009046_muscle_twitch0.77094303
90MP0005636_abnormal_mineral_homeostasis0.76972520
91MP0003890_abnormal_embryonic-extraembry0.76694049
92MP0002653_abnormal_ependyma_morphology0.75289745
93MP0000631_abnormal_neuroendocrine_gland0.74845725
94MP0001440_abnormal_grooming_behavior0.74192333
95MP0003718_maternal_effect0.73945681
96MP0001963_abnormal_hearing_physiology0.72367581
97MP0002078_abnormal_glucose_homeostasis0.72198817
98MP0000639_abnormal_adrenal_gland0.70232115
99MP0002734_abnormal_mechanical_nocicepti0.70109186
100MP0009115_abnormal_fat_cell0.69200549

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.30668679
2Birth length less than 3rd percentile (HP:0003561)4.16150181
3Congenital stationary night blindness (HP:0007642)3.92570834
4Hyperlipoproteinemia (HP:0010980)3.65937226
5Attenuation of retinal blood vessels (HP:0007843)3.51419482
6Abnormality of midbrain morphology (HP:0002418)3.48247161
7Molar tooth sign on MRI (HP:0002419)3.48247161
8Pancreatic cysts (HP:0001737)3.33025977
9Deep venous thrombosis (HP:0002625)3.19594885
10Complement deficiency (HP:0004431)3.14221136
11Joint hemorrhage (HP:0005261)3.13613510
12Abnormality of the renal cortex (HP:0011035)3.11894202
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.10204965
14Nephronophthisis (HP:0000090)3.09609509
15Pancreatic fibrosis (HP:0100732)3.02164003
16Hypobetalipoproteinemia (HP:0003563)3.00730958
17True hermaphroditism (HP:0010459)2.97397867
18Chronic hepatic failure (HP:0100626)2.96491236
19Hyperglycinuria (HP:0003108)2.96227127
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88709071
21Abnormality of alanine metabolism (HP:0010916)2.88709071
22Hyperalaninemia (HP:0003348)2.88709071
23Xanthomatosis (HP:0000991)2.83986021
24Hyperglycinemia (HP:0002154)2.81308362
25Abolished electroretinogram (ERG) (HP:0000550)2.79567855
26Generalized aminoaciduria (HP:0002909)2.76699637
27Abnormality of glycine metabolism (HP:0010895)2.76602420
28Abnormality of serine family amino acid metabolism (HP:0010894)2.76602420
29Abnormal biliary tract physiology (HP:0012439)2.73601043
30Bile duct proliferation (HP:0001408)2.73601043
31Abnormality of the renal medulla (HP:0100957)2.72401641
32Pendular nystagmus (HP:0012043)2.69409282
33Abnormal drinking behavior (HP:0030082)2.65826726
34Polydipsia (HP:0001959)2.65826726
35Renal cortical cysts (HP:0000803)2.65688879
36Concave nail (HP:0001598)2.62626117
37Bony spicule pigmentary retinopathy (HP:0007737)2.49044689
38Type II lissencephaly (HP:0007260)2.48634563
39Decreased circulating renin level (HP:0003351)2.47324911
40Delayed CNS myelination (HP:0002188)2.43229593
41Lissencephaly (HP:0001339)2.43221373
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.41769722
43Polyuria (HP:0000103)2.33848403
44Hyperventilation (HP:0002883)2.32147060
45Protruding tongue (HP:0010808)2.30658469
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.30093873
47Absent/shortened dynein arms (HP:0200106)2.30093873
48Patellar aplasia (HP:0006443)2.28292988
49Medial flaring of the eyebrow (HP:0010747)2.27380174
50Tubular atrophy (HP:0000092)2.26817277
51Conjugated hyperbilirubinemia (HP:0002908)2.26467189
52Hypothermia (HP:0002045)2.26358311
53Arthropathy (HP:0003040)2.24953674
54Abnormal urine output (HP:0012590)2.24139346
55Abnormal respiratory epithelium morphology (HP:0012253)2.23560017
56Abnormal respiratory motile cilium morphology (HP:0005938)2.23560017
57Abnormal rod and cone electroretinograms (HP:0008323)2.18402774
58Abnormality of urine glucose concentration (HP:0011016)2.15613662
59Glycosuria (HP:0003076)2.15613662
60Abnormality of proline metabolism (HP:0010907)2.14548724
61Hydroxyprolinuria (HP:0003080)2.14548724
62Aplasia/Hypoplasia of the patella (HP:0006498)2.12971860
63Inability to walk (HP:0002540)2.11436065
64Renal Fanconi syndrome (HP:0001994)2.11231602
65Increased corneal curvature (HP:0100692)2.10452071
66Keratoconus (HP:0000563)2.10452071
67Spontaneous abortion (HP:0005268)2.10251485
68Epidermoid cyst (HP:0200040)2.08422573
69Cystic liver disease (HP:0006706)2.07966333
70Decreased central vision (HP:0007663)2.06662488
71Hypoglycemic seizures (HP:0002173)2.04646229
72Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04392121
73Abnormality of serum amino acid levels (HP:0003112)2.00938965
74Breast hypoplasia (HP:0003187)1.98328591
75Gait imbalance (HP:0002141)1.97056358
76Chorioretinal atrophy (HP:0000533)1.90782301
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90376454
78Stomach cancer (HP:0012126)1.88730340
79Optic disc pallor (HP:0000543)1.87501378
80Abnormality of the pons (HP:0007361)1.87165264
81Progressive inability to walk (HP:0002505)1.85694853
82Abnormality of renal excretion (HP:0011036)1.84671013
83Abnormal ciliary motility (HP:0012262)1.84118108
84Abnormality of complement system (HP:0005339)1.83884601
85Congenital sensorineural hearing impairment (HP:0008527)1.83544685
86Furrowed tongue (HP:0000221)1.78878113
87Congenital primary aphakia (HP:0007707)1.78682620
88Increased hepatocellular lipid droplets (HP:0006565)1.78341853
89Pigmentary retinal degeneration (HP:0001146)1.77976286
90Hypophosphatemic rickets (HP:0004912)1.77483696
91Pachygyria (HP:0001302)1.77158955
92Recurrent corneal erosions (HP:0000495)1.75510547
93Large for gestational age (HP:0001520)1.74928216
94Glomerulonephritis (HP:0000099)1.74140771
95Congenital, generalized hypertrichosis (HP:0004540)1.72824390
96Nephrogenic diabetes insipidus (HP:0009806)1.72331652
97Hypoplasia of the pons (HP:0012110)1.70643295
98Acute encephalopathy (HP:0006846)1.69320829
99Ketosis (HP:0001946)1.67268523
100Hyperphosphaturia (HP:0003109)1.66681911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.67326938
2ADRBK23.62186159
3ACVR1B3.57713161
4WNK43.50165190
5INSRR3.19860806
6CASK3.11612295
7WNK33.09233891
8ZAK2.97737909
9BMPR1B2.70462455
10PINK12.67908088
11FRK2.64052151
12MAP4K22.29829242
13TAOK32.20369259
14GRK12.18739582
15DAPK22.16445671
16NTRK31.99439796
17MARK11.97322077
18TXK1.81568139
19STK391.74111196
20MAPK131.65098711
21PIK3CA1.53529025
22MUSK1.50354357
23ADRBK11.39418807
24OXSR11.37471882
25TGFBR11.27946371
26NUAK11.23385536
27MAP3K41.20137787
28DYRK21.18393379
29MAP2K61.17533772
30SIK21.05481956
31PAK30.99550552
32FGFR20.97938301
33ERBB20.97678021
34PRKCG0.97505959
35TNIK0.97298285
36BCKDK0.92073391
37PHKG10.89836817
38PHKG20.89836817
39MAP2K70.88413987
40PNCK0.83306613
41ABL20.81198029
42MAP2K40.80177254
43MAPKAPK30.79554053
44TNK20.78277330
45NTRK20.77147101
46PRKAA20.76595872
47TIE10.76574881
48VRK10.75127859
49EPHB20.72842169
50CAMKK20.66829862
51PRKACA0.64122843
52CAMKK10.63126125
53RPS6KA50.61734488
54NME10.60837826
55MAPK150.60463166
56STK110.57806138
57CAMK10.57344931
58DYRK1B0.57208600
59MAP2K10.56956152
60PRKCE0.56559308
61PRKAA10.55465008
62GRK70.55010697
63OBSCN0.53971887
64PRKCZ0.52785621
65CAMK2A0.52440006
66PRKACG0.52349845
67TEC0.51848124
68DYRK1A0.51453378
69MAP2K20.51272470
70PRKG10.51060973
71EPHA40.46755903
72MAP3K110.46379846
73PRKCQ0.45826489
74IKBKB0.45048674
75PKN10.44793202
76STK38L0.44051012
77CHUK0.43839658
78PRKD20.41907199
79PRKACB0.38418437
80PRKG20.37479148
81EPHA30.37291264
82PTK2B0.36066833
83KIT0.35683684
84PRKCA0.35475084
85RPS6KA60.35217347
86CSNK1A10.34868441
87WNK10.33430009
88PLK40.33177119
89ITK0.33028647
90CAMK1D0.32721719
91MAPKAPK50.32719652
92CSNK1D0.31581273
93IGF1R0.30797568
94CAMK1G0.30723183
95CSNK1E0.28304497
96NEK10.28303859
97CLK10.27082333
98SYK0.25153014
99MATK0.24063868
100LYN0.23978657

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.63009652
2Linoleic acid metabolism_Homo sapiens_hsa005913.14162949
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.82243028
4Butanoate metabolism_Homo sapiens_hsa006502.67458820
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54798139
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.53183657
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.52517593
8Complement and coagulation cascades_Homo sapiens_hsa046102.47204769
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.45983840
10Chemical carcinogenesis_Homo sapiens_hsa052042.35353957
11Retinol metabolism_Homo sapiens_hsa008302.30620995
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.15025661
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09837775
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.05091660
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03634557
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98975912
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.93604521
18Fat digestion and absorption_Homo sapiens_hsa049751.93391207
19Nitrogen metabolism_Homo sapiens_hsa009101.86327550
20Tryptophan metabolism_Homo sapiens_hsa003801.82948457
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78135210
22Phototransduction_Homo sapiens_hsa047441.66908517
23Fatty acid degradation_Homo sapiens_hsa000711.63733838
24Sulfur relay system_Homo sapiens_hsa041221.63568672
25ABC transporters_Homo sapiens_hsa020101.61732802
26Arginine biosynthesis_Homo sapiens_hsa002201.58690815
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.58163555
28Histidine metabolism_Homo sapiens_hsa003401.54894756
29Tyrosine metabolism_Homo sapiens_hsa003501.50691894
30Arachidonic acid metabolism_Homo sapiens_hsa005901.49675891
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46654830
32Peroxisome_Homo sapiens_hsa041461.41518399
33Ether lipid metabolism_Homo sapiens_hsa005651.38480295
34Bile secretion_Homo sapiens_hsa049761.35666068
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.29862332
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.27557645
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27093535
38Propanoate metabolism_Homo sapiens_hsa006401.25243556
39Fatty acid biosynthesis_Homo sapiens_hsa000611.24462875
40Oxidative phosphorylation_Homo sapiens_hsa001901.22674755
41PPAR signaling pathway_Homo sapiens_hsa033201.15488364
42One carbon pool by folate_Homo sapiens_hsa006701.14422502
43Phenylalanine metabolism_Homo sapiens_hsa003601.14392475
44beta-Alanine metabolism_Homo sapiens_hsa004101.10951443
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07453481
46Nicotine addiction_Homo sapiens_hsa050331.05886255
47Selenocompound metabolism_Homo sapiens_hsa004501.03506547
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02904480
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99817712
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97339994
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95755155
52Starch and sucrose metabolism_Homo sapiens_hsa005000.90475719
53Glycerolipid metabolism_Homo sapiens_hsa005610.89491334
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88677850
55Parkinsons disease_Homo sapiens_hsa050120.87328593
56Arginine and proline metabolism_Homo sapiens_hsa003300.84170341
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84072385
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.83567219
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81807660
60Steroid biosynthesis_Homo sapiens_hsa001000.80531630
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79710456
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.78388156
63Vitamin digestion and absorption_Homo sapiens_hsa049770.71936754
64Fatty acid metabolism_Homo sapiens_hsa012120.71004721
65Olfactory transduction_Homo sapiens_hsa047400.68744839
66Serotonergic synapse_Homo sapiens_hsa047260.67490073
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.66987922
68Staphylococcus aureus infection_Homo sapiens_hsa051500.65841852
69Taste transduction_Homo sapiens_hsa047420.65333034
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65172726
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62231179
72Metabolic pathways_Homo sapiens_hsa011000.60775696
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58845590
74Sulfur metabolism_Homo sapiens_hsa009200.55367981
75Morphine addiction_Homo sapiens_hsa050320.54021023
76GABAergic synapse_Homo sapiens_hsa047270.54018284
77Ovarian steroidogenesis_Homo sapiens_hsa049130.53490757
78Alzheimers disease_Homo sapiens_hsa050100.52702158
79Cardiac muscle contraction_Homo sapiens_hsa042600.52475540
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.47629167
81Circadian entrainment_Homo sapiens_hsa047130.46280604
82Regulation of autophagy_Homo sapiens_hsa041400.43947042
83Insulin secretion_Homo sapiens_hsa049110.42040488
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.41831076
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.38957827
86Pyruvate metabolism_Homo sapiens_hsa006200.37850553
87Ribosome_Homo sapiens_hsa030100.37639367
88Huntingtons disease_Homo sapiens_hsa050160.35786667
89Mineral absorption_Homo sapiens_hsa049780.35696149
90RNA polymerase_Homo sapiens_hsa030200.35037273
91Basal transcription factors_Homo sapiens_hsa030220.34649385
92Glutamatergic synapse_Homo sapiens_hsa047240.33662401
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29065970
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28789887
95Protein export_Homo sapiens_hsa030600.26919545
96Cocaine addiction_Homo sapiens_hsa050300.25417734
97Calcium signaling pathway_Homo sapiens_hsa040200.21463213
98Homologous recombination_Homo sapiens_hsa034400.18981919
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15995979
100Primary immunodeficiency_Homo sapiens_hsa053400.15914656

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »