AOC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.43149258
2positive regulation by symbiont of host defense response (GO:0052509)5.73636201
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.73636201
4detection of molecule of bacterial origin (GO:0032490)5.25067386
5nuclear pore complex assembly (GO:0051292)5.01835249
6macrophage activation involved in immune response (GO:0002281)4.95199348
7negative regulation of cell killing (GO:0031342)4.93694864
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.93694864
9regulation of interferon-beta biosynthetic process (GO:0045357)4.63294823
10nuclear pore organization (GO:0006999)4.62904365
11positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.40612565
12response to peptidoglycan (GO:0032494)4.30866120
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.28289862
14pore complex assembly (GO:0046931)4.26075166
15interferon-gamma production (GO:0032609)4.17101129
16detection of external biotic stimulus (GO:0098581)4.13830167
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04540182
18positive regulation of gamma-delta T cell activation (GO:0046645)4.00593628
19negative regulation of Rho protein signal transduction (GO:0035024)3.99725962
20neutrophil activation involved in immune response (GO:0002283)3.97142295
21detection of other organism (GO:0098543)3.89134135
22leukocyte migration involved in inflammatory response (GO:0002523)3.87771402
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.84815182
24regulation of T-helper 2 cell differentiation (GO:0045628)3.84316241
25cellular extravasation (GO:0045123)3.83058886
26sperm capacitation (GO:0048240)3.69218885
27negative regulation of interleukin-12 production (GO:0032695)3.65553719
28response to host immune response (GO:0052572)3.64078403
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64078403
30antigen processing and presentation of endogenous antigen (GO:0019883)3.63276540
31DNA synthesis involved in DNA repair (GO:0000731)3.58394932
32respiratory burst (GO:0045730)3.57742684
33synaptonemal complex assembly (GO:0007130)3.55871579
34neutrophil activation (GO:0042119)3.55063681
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52658248
36histone H3-K9 demethylation (GO:0033169)3.51503022
37neutrophil mediated immunity (GO:0002446)3.50950505
38detection of bacterium (GO:0016045)3.48973495
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.48528241
40synapsis (GO:0007129)3.47154927
41detection of biotic stimulus (GO:0009595)3.46378423
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44810185
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41895153
44response to host (GO:0075136)3.41895153
45response to host defenses (GO:0052200)3.41895153
46regulation of ARF GTPase activity (GO:0032312)3.40357686
47snRNA processing (GO:0016180)3.35640544
48macrophage activation (GO:0042116)3.34764643
49leukocyte aggregation (GO:0070486)3.34036721
50definitive hemopoiesis (GO:0060216)3.33881253
51snRNA metabolic process (GO:0016073)3.32999008
52regulation of mast cell degranulation (GO:0043304)3.32077528
53male meiosis I (GO:0007141)3.30384390
54myeloid cell activation involved in immune response (GO:0002275)3.27416438
55positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.26577643
56granulocyte activation (GO:0036230)3.26173576
57chromosome organization involved in meiosis (GO:0070192)3.25809895
58negative regulation of toll-like receptor signaling pathway (GO:0034122)3.24512349
59low-density lipoprotein particle clearance (GO:0034383)3.19914313
60meiotic chromosome segregation (GO:0045132)3.18395716
61phosphatidylethanolamine biosynthetic process (GO:0006646)3.17860403
62negative regulation of interleukin-8 production (GO:0032717)3.12046157
63negative regulation of cAMP-mediated signaling (GO:0043951)3.07440802
64regulation of mitotic spindle checkpoint (GO:1903504)3.04471075
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04471075
66piRNA metabolic process (GO:0034587)3.03298878
67regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03157468
68regulation of mast cell activation involved in immune response (GO:0033006)3.02041934
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99984920
70negative T cell selection (GO:0043383)2.97726927
71negative regulation of leukocyte mediated immunity (GO:0002704)2.97240057
72regulation of gamma-delta T cell activation (GO:0046643)2.96176926
73positive regulation of DNA-dependent DNA replication (GO:2000105)2.95386605
74synaptonemal complex organization (GO:0070193)2.93495577
75regulation of leukocyte degranulation (GO:0043300)2.92209732
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89405263
77myeloid dendritic cell activation (GO:0001773)2.88765813
78negative regulation of DNA-dependent DNA replication (GO:2000104)2.88685745
79negative thymic T cell selection (GO:0045060)2.88365683
80response to type I interferon (GO:0034340)2.88260776
81cellular response to type I interferon (GO:0071357)2.87778036
82type I interferon signaling pathway (GO:0060337)2.87778036
83phosphatidylethanolamine metabolic process (GO:0046337)2.87721103
84microglial cell activation (GO:0001774)2.86930568
85positive regulation of NF-kappaB import into nucleus (GO:0042346)2.86190366
86leukocyte degranulation (GO:0043299)2.85759495
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.82369688
88negative regulation of innate immune response (GO:0045824)2.79442040
89DNA packaging (GO:0006323)2.78686892
90NIK/NF-kappaB signaling (GO:0038061)2.78297539
91regulation of gamma-delta T cell differentiation (GO:0045586)2.78060847
92sperm motility (GO:0030317)2.78050558
93rRNA methylation (GO:0031167)2.77538221
94regulation of B cell receptor signaling pathway (GO:0050855)2.76760007
95erythrocyte maturation (GO:0043249)2.76756169
96pantothenate metabolic process (GO:0015939)2.76516355
97histone demethylation (GO:0016577)2.76203808
98myeloid leukocyte mediated immunity (GO:0002444)2.75531696
99histone H3-K36 demethylation (GO:0070544)2.75414706
100regulation of toll-like receptor signaling pathway (GO:0034121)2.70986651
101positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70959797
102positive regulation of interferon-alpha production (GO:0032727)2.70434498
103negative regulation of inclusion body assembly (GO:0090084)2.70219797
104negative regulation of type 2 immune response (GO:0002829)2.68481005
105regulation of alpha-beta T cell proliferation (GO:0046640)2.67713976
106regulation of interleukin-2 biosynthetic process (GO:0045076)2.67347264
107termination of RNA polymerase I transcription (GO:0006363)2.67104612
108DNA methylation involved in gamete generation (GO:0043046)2.66784191
109positive regulation of toll-like receptor signaling pathway (GO:0034123)2.66740201
110histone lysine demethylation (GO:0070076)2.65840331
111positive regulation of Cdc42 GTPase activity (GO:0043089)2.65417989
112rRNA modification (GO:0000154)2.65324426
113IMP biosynthetic process (GO:0006188)2.64264678
114positive regulation of interleukin-2 production (GO:0032743)2.63521533
115fusion of sperm to egg plasma membrane (GO:0007342)2.62943027
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.62823830
117regulation of histone H3-K27 methylation (GO:0061085)2.62750611
118negative regulation of interleukin-6 production (GO:0032715)2.61887677
119megakaryocyte development (GO:0035855)2.61740691
120regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61709671
121regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.61031402
122chromosome condensation (GO:0030261)2.59970556
123telomere maintenance via recombination (GO:0000722)2.58888634
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58811968
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.58375726
126maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.56587582
127production of molecular mediator involved in inflammatory response (GO:0002532)2.55823796
128transcription elongation from RNA polymerase I promoter (GO:0006362)2.52362479
129positive regulation of T cell chemotaxis (GO:0010820)2.51217964
130regulation of T cell chemotaxis (GO:0010819)2.51217964
131DNA replication checkpoint (GO:0000076)2.50686202
132replication fork processing (GO:0031297)2.49646139
133germinal center formation (GO:0002467)2.49441275
134inner cell mass cell proliferation (GO:0001833)2.49152270
135histone H3-K4 trimethylation (GO:0080182)2.49134064
136negative regulation of phagocytosis (GO:0050765)2.48569128
137energy homeostasis (GO:0097009)2.46021538
138response to interleukin-15 (GO:0070672)2.45312488
139lymphocyte homeostasis (GO:0002260)2.45150345
140positive thymic T cell selection (GO:0045059)2.44177339
141telomere maintenance via semi-conservative replication (GO:0032201)2.43866222
142lymph node development (GO:0048535)2.43862297
143DNA-dependent DNA replication (GO:0006261)2.42851841
144regulation of spindle organization (GO:0090224)2.42779499
145protoporphyrinogen IX biosynthetic process (GO:0006782)2.41840625
146T cell homeostasis (GO:0043029)2.41479411
147myeloid dendritic cell differentiation (GO:0043011)2.41429828
148erythrocyte development (GO:0048821)2.41247771
149T cell migration (GO:0072678)2.40001536
150positive T cell selection (GO:0043368)2.39887920
151modulation by virus of host process (GO:0019054)2.39469420
152positive regulation of antigen processing and presentation (GO:0002579)2.39225472
153cellular response to interleukin-15 (GO:0071350)2.39138842
154positive regulation of isotype switching (GO:0045830)2.38563077
155dendritic cell chemotaxis (GO:0002407)2.37435962
156positive regulation of humoral immune response (GO:0002922)2.34193239
157histone H3-K9 methylation (GO:0051567)2.34108792
158DNA strand elongation (GO:0022616)2.33789488
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.33516280
160mature B cell differentiation (GO:0002335)2.32521781
161mitotic nuclear envelope disassembly (GO:0007077)2.31618342
162mitotic recombination (GO:0006312)2.31614675
163T cell selection (GO:0045058)2.29720659
164DNA strand elongation involved in DNA replication (GO:0006271)2.29462622
165histone H3-K4 methylation (GO:0051568)2.29180698
166regulation of DNA-dependent DNA replication (GO:0090329)2.29104076
167kinetochore organization (GO:0051383)2.29013845
168transcription initiation from RNA polymerase I promoter (GO:0006361)2.28292673
169regulation of antigen processing and presentation (GO:0002577)2.27068103
170regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26954946
171defense response to protozoan (GO:0042832)2.26681716
172DNA replication initiation (GO:0006270)2.26638844
173positive regulation of granulocyte differentiation (GO:0030854)2.25038659
174regulation of activation of Janus kinase activity (GO:0010533)2.24218782
175response to protozoan (GO:0001562)2.23316265
176alpha-beta T cell activation (GO:0046631)2.23273216
177regulation of regulatory T cell differentiation (GO:0045589)2.23247920
178positive regulation of interferon-gamma production (GO:0032729)2.22886146
179embryonic hemopoiesis (GO:0035162)2.22421053
180regulation of isotype switching to IgG isotypes (GO:0048302)2.22403655
181modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22309064
182positive regulation by organism of defense response of other organism involved in symbiotic interact2.22309064
183modulation by symbiont of host immune response (GO:0052553)2.22309064
184modulation by symbiont of host defense response (GO:0052031)2.22309064

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.97708440
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61763952
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.30689201
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.25404227
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24323167
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19730213
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.13456891
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.09784812
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.05589594
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.94371554
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59828853
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52849199
13SCL_19346495_ChIP-Seq_HPC-7_Human2.42935723
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.38668993
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27939605
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22134212
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21456667
18LXR_22292898_ChIP-Seq_THP-1_Human2.20516250
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.17016663
20MYC_22102868_ChIP-Seq_BL_Human2.15889176
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.15228468
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.13891929
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10312677
24SPI1_23127762_ChIP-Seq_K562_Human2.09266965
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08238004
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.07882205
27P68_20966046_ChIP-Seq_HELA_Human2.05452371
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04257652
29KDM2B_26808549_Chip-Seq_DND41_Human2.02354993
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00518457
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.98980086
32ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97348588
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95858204
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93184851
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92855171
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86546595
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85152387
38BCL6_27268052_Chip-Seq_Bcells_Human1.84472656
39BCOR_27268052_Chip-Seq_Bcells_Human1.82587826
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78831460
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.78025183
42MYB_26560356_Chip-Seq_TH1_Human1.73848821
43SMC4_20622854_ChIP-Seq_HELA_Human1.73433911
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72490717
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.71143106
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.70372910
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69973796
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.68059205
49CIITA_25753668_ChIP-Seq_RAJI_Human1.65012832
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63504111
51RUNX_20019798_ChIP-Seq_JUKART_Human1.62686571
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59446215
53GATA1_22025678_ChIP-Seq_K562_Human1.57768756
54MYB_26560356_Chip-Seq_TH2_Human1.54971664
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51169155
56E2F1_20622854_ChIP-Seq_HELA_Human1.51009200
57SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.49978491
58VDR_23849224_ChIP-Seq_CD4+_Human1.49286179
59EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48611518
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48536812
61PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48498433
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48392502
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47326826
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46421451
65ELK1_19687146_ChIP-ChIP_HELA_Human1.46208887
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.44158792
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.43873058
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43692999
69FOXP3_21729870_ChIP-Seq_TREG_Human1.43321052
70SPI1_23547873_ChIP-Seq_NB4_Human1.42957937
71PHF8_20622854_ChIP-Seq_HELA_Human1.42700861
72MAF_26560356_Chip-Seq_TH1_Human1.42518389
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42475231
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.42408469
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42119385
76RUNX1_22412390_ChIP-Seq_EML_Mouse1.41300991
77RACK7_27058665_Chip-Seq_MCF-7_Human1.41161662
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41110485
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39055752
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38424120
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38364512
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.38111197
83BP1_19119308_ChIP-ChIP_Hs578T_Human1.37019167
84KDM2B_26808549_Chip-Seq_K562_Human1.36749085
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.36691275
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35718099
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.35256846
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34498438
89* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34472751
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33952290
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33564246
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33520339
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.33504200
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.33215941
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32920230
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32462471
97NCOR1_26117541_ChIP-Seq_K562_Human1.31626273
98ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30677289
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28971207
100YY1_22570637_ChIP-Seq_MALME-3M_Human1.27895057
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.27264821
102NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23628141
103EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22979569
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22182622
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20669320
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.20216135
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19971446
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17971140
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17969072
110* SA1_27219007_Chip-Seq_Bcells_Human1.16738868
111CTCF_21964334_Chip-Seq_Bcells_Human1.16585253
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16176028
113CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15450883
114RAC3_21632823_ChIP-Seq_H3396_Human1.14791543
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13733070
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12141563
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11263990
118JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10708140
119UTX_26944678_Chip-Seq_JUKART_Human1.09213267
120RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09076884
121ATF3_27146783_Chip-Seq_COLON_Human1.08643113
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08256851
123VDR_24763502_ChIP-Seq_THP-1_Human1.08052374
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07803459
125TET1_21451524_ChIP-Seq_MESCs_Mouse1.07765099
126* ERA_21632823_ChIP-Seq_H3396_Human1.07654516
127RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06840790
128CREB1_26743006_Chip-Seq_LNCaP_Human1.06432255
129SMAD_19615063_ChIP-ChIP_OVARY_Human1.06386778
130TCF7_22412390_ChIP-Seq_EML_Mouse1.06351045
131MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05858815
132PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05365440
133* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05290330
134DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05285611
135P300_27268052_Chip-Seq_Bcells_Human1.05242589
136VDR_21846776_ChIP-Seq_THP-1_Human1.05075837
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04613579
138MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04110142
139POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03418260
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01935344
141NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00706168
142E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97306987
143LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97259433
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96656650
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.96579511
146GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94851818
147ETS1_20019798_ChIP-Seq_JURKAT_Human0.93247074
148KDM5A_27292631_Chip-Seq_BREAST_Human0.92971397
149BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92615521
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89909961
151IRF1_19129219_ChIP-ChIP_H3396_Human0.88516866
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88228599
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87476988
154GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87020316
155RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87000687
156* MAF_26560356_Chip-Seq_TH2_Human0.86834932
157CREB1_15753290_ChIP-ChIP_HEK293T_Human0.85877412
158PU_27001747_Chip-Seq_BMDM_Mouse0.85361085
159AR_21909140_ChIP-Seq_LNCAP_Human0.84829865
160GATA3_27048872_Chip-Seq_THYMUS_Human0.84509440
161XRN2_22483619_ChIP-Seq_HELA_Human0.81502644
162KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81457672
163POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80844750
164E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80698189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.17914168
2MP0005410_abnormal_fertilization3.12634844
3MP0001835_abnormal_antigen_presentation3.03841041
4MP0003300_gastrointestinal_ulcer2.99023836
5MP0003303_peritoneal_inflammation2.95382760
6MP0003763_abnormal_thymus_physiology2.90645444
7MP0008058_abnormal_DNA_repair2.85283321
8MP0005451_abnormal_body_composition2.78564455
9MP0003111_abnormal_nucleus_morphology2.64721752
10MP0003787_abnormal_imprinting2.58614688
11MP0005671_abnormal_response_to2.56246143
12MP0008007_abnormal_cellular_replicative2.45685730
13MP0002396_abnormal_hematopoietic_system2.45669171
14MP0000685_abnormal_immune_system2.39192039
15MP0003191_abnormal_cellular_cholesterol2.35568326
16MP0010094_abnormal_chromosome_stability2.33760514
17MP0001800_abnormal_humoral_immune2.23379500
18MP0005387_immune_system_phenotype2.18708263
19MP0001790_abnormal_immune_system2.18708263
20MP0003077_abnormal_cell_cycle2.18183930
21MP0003693_abnormal_embryo_hatching2.13152080
22MP0002398_abnormal_bone_marrow2.10151442
23MP0005397_hematopoietic_system_phenotyp2.07063968
24MP0001545_abnormal_hematopoietic_system2.07063968
25MP0004808_abnormal_hematopoietic_stem2.03936841
26MP0003011_delayed_dark_adaptation2.02739280
27MP0009278_abnormal_bone_marrow1.98865653
28MP0005666_abnormal_adipose_tissue1.94197649
29MP0002452_abnormal_antigen_presenting1.93416116
30MP0005377_hearing/vestibular/ear_phenot1.92897392
31MP0003878_abnormal_ear_physiology1.92897392
32MP0009333_abnormal_splenocyte_physiolog1.87961178
33MP0004147_increased_porphyrin_level1.85602494
34MP0002420_abnormal_adaptive_immunity1.84130605
35MP0001819_abnormal_immune_cell1.82121374
36MP0005000_abnormal_immune_tolerance1.80399796
37MP0009785_altered_susceptibility_to1.79157248
38MP0002132_abnormal_respiratory_system1.77796566
39MP0003656_abnormal_erythrocyte_physiolo1.74245493
40MP0002723_abnormal_immune_serum1.73435313
41MP0000703_abnormal_thymus_morphology1.69595273
42MP0002138_abnormal_hepatobiliary_system1.69176574
43MP0000716_abnormal_immune_system1.68499748
44MP0003436_decreased_susceptibility_to1.65831948
45MP0002148_abnormal_hypersensitivity_rea1.64259900
46MP0004381_abnormal_hair_follicle1.63965038
47MP0002722_abnormal_immune_system1.63548639
48MP0000689_abnormal_spleen_morphology1.62983297
49MP0003890_abnormal_embryonic-extraembry1.61280826
50MP0002405_respiratory_system_inflammati1.59242251
51MP0002429_abnormal_blood_cell1.54538216
52MP0005025_abnormal_response_to1.53554977
53MP0003195_calcinosis1.48734696
54MP0005083_abnormal_biliary_tract1.47930883
55MP0003698_abnormal_male_reproductive1.47825468
56MP0004185_abnormal_adipocyte_glucose1.46587395
57MP0002419_abnormal_innate_immunity1.46160566
58MP0001929_abnormal_gametogenesis1.44845065
59MP0003943_abnormal_hepatobiliary_system1.37195855
60MP0000490_abnormal_crypts_of1.37150289
61MP0005670_abnormal_white_adipose1.36852540
62MP0003828_pulmonary_edema1.35666521
63MP0002928_abnormal_bile_duct1.34178042
64MP0006292_abnormal_olfactory_placode1.33892768
65MP0005375_adipose_tissue_phenotype1.33068585
66MP0005365_abnormal_bile_salt1.32612601
67MP0004957_abnormal_blastocyst_morpholog1.31519600
68MP0010155_abnormal_intestine_physiology1.31396808
69MP0004130_abnormal_muscle_cell1.31143712
70MP0000350_abnormal_cell_proliferation1.28320263
71MP0002277_abnormal_respiratory_mucosa1.28010385
72MP0005409_darkened_coat_color1.27910194
73MP0004947_skin_inflammation1.24966350
74MP0008469_abnormal_protein_level1.24036391
75MP0003121_genomic_imprinting1.19483310
76MP0005164_abnormal_response_to1.18572352
77MP0002006_tumorigenesis1.18562847
78MP0001348_abnormal_lacrimal_gland1.18450193
79MP0002210_abnormal_sex_determination1.13838401
80MP0008877_abnormal_DNA_methylation1.13627263
81MP0003172_abnormal_lysosome_physiology1.13442195
82MP0002998_abnormal_bone_remodeling1.13428701
83MP0002933_joint_inflammation1.12175662
84MP0000678_abnormal_parathyroid_gland1.10595641
85MP0001853_heart_inflammation1.10234903
86MP0008260_abnormal_autophagy1.09735421
87MP0005464_abnormal_platelet_physiology1.09104575
88MP0003724_increased_susceptibility_to1.08617349
89MP0010307_abnormal_tumor_latency1.08521384
90MP0004883_abnormal_blood_vessel1.07422710
91MP0001986_abnormal_taste_sensitivity1.06930287
92MP0003705_abnormal_hypodermis_morpholog1.06872070
93MP0008789_abnormal_olfactory_epithelium1.05542224
94MP0003786_premature_aging1.05370760
95MP0005394_taste/olfaction_phenotype1.05311282
96MP0005499_abnormal_olfactory_system1.05311282
97MP0001873_stomach_inflammation1.05064364
98MP0000609_abnormal_liver_physiology1.02923419
99MP0002166_altered_tumor_susceptibility1.01654554
100MP0006082_CNS_inflammation1.01037237
101MP0003567_abnormal_fetal_cardiomyocyte0.99559153
102MP0000858_altered_metastatic_potential0.98640780
103MP0004233_abnormal_muscle_weight0.98390257
104MP0005171_absent_coat_pigmentation0.97349002
105MP0000313_abnormal_cell_death0.96995426
106MP0001845_abnormal_inflammatory_respons0.96037721
107MP0002971_abnormal_brown_adipose0.95693981
108MP0009697_abnormal_copulation0.91876937
109MP0009115_abnormal_fat_cell0.91817041
110MP0000015_abnormal_ear_pigmentation0.91525116
111MP0005647_abnormal_sex_gland0.91413959
112MP0005423_abnormal_somatic_nervous0.90772568
113MP0003252_abnormal_bile_duct0.89268890
114MP0002019_abnormal_tumor_incidence0.88203525
115MP0001119_abnormal_female_reproductive0.87840668
116MP0002877_abnormal_melanocyte_morpholog0.87639378
117MP0002089_abnormal_postnatal_growth/wei0.87544402
118MP0005174_abnormal_tail_pigmentation0.86646349
119MP0008874_decreased_physiological_sensi0.86460878
120MP0001293_anophthalmia0.85177258
121MP0009764_decreased_sensitivity_to0.84904746
122MP0006054_spinal_hemorrhage0.83826824
123MP0003448_altered_tumor_morphology0.83080641
124MP0001145_abnormal_male_reproductive0.82473627
125MP0002161_abnormal_fertility/fecundity0.80192643
126MP0002118_abnormal_lipid_homeostasis0.80150857
127MP0005248_abnormal_Harderian_gland0.80147554
128MP0002254_reproductive_system_inflammat0.79762401
129MP0005334_abnormal_fat_pad0.78075535
130MP0001188_hyperpigmentation0.77080198
131MP0003866_abnormal_defecation0.76102784
132MP0005380_embryogenesis_phenotype0.75726553
133MP0001672_abnormal_embryogenesis/_devel0.75726553
134MP0003941_abnormal_skin_development0.74124043
135MP0005076_abnormal_cell_differentiation0.73705488
136MP0004197_abnormal_fetal_growth/weight/0.73306819
137MP0002163_abnormal_gland_morphology0.73303563
138MP0004782_abnormal_surfactant_physiolog0.72442899
139MP0005535_abnormal_body_temperature0.72308554
140MP0000465_gastrointestinal_hemorrhage0.72081251
141MP0004019_abnormal_vitamin_homeostasis0.71978498
142MP0005310_abnormal_salivary_gland0.71481030
143MP0004510_myositis0.71257367
144MP0001286_abnormal_eye_development0.71109439
145MP0003221_abnormal_cardiomyocyte_apopto0.69968809
146MP0002009_preneoplasia0.69295086
147MP0001919_abnormal_reproductive_system0.68115761
148MP0005621_abnormal_cell_physiology0.67923326
149MP0003315_abnormal_perineum_morphology0.67894284
150MP0008932_abnormal_embryonic_tissue0.67031420
151MP0001533_abnormal_skeleton_physiology0.65611446

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.84757270
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.84302336
3Gastrointestinal infarctions (HP:0005244)4.59792781
4Recurrent gram-negative bacterial infections (HP:0005420)4.26312888
5Abnormality of macrophages (HP:0004311)4.24331857
6Chromsome breakage (HP:0040012)4.23318068
7Abnormality of the fingertips (HP:0001211)3.82728529
8Keratoconjunctivitis (HP:0001096)3.57133686
9Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.54629773
10Male infertility (HP:0003251)3.47024126
11Chronic obstructive pulmonary disease (HP:0006510)3.46218082
12Obstructive lung disease (HP:0006536)3.46218082
13Abnormality of the heme biosynthetic pathway (HP:0010472)3.35017979
14Hypochromic anemia (HP:0001931)3.31908218
15Gingivitis (HP:0000230)3.21060900
16Hypochromic microcytic anemia (HP:0004840)3.19995453
17Elevated erythrocyte sedimentation rate (HP:0003565)3.15400132
18Metaphyseal cupping (HP:0003021)3.11567824
19Azoospermia (HP:0000027)3.09164410
20Ectopic kidney (HP:0000086)3.08694374
21Peritonitis (HP:0002586)3.02811213
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.87829062
23Acute hepatic failure (HP:0006554)2.75638287
24Increased IgE level (HP:0003212)2.75503198
25Recurrent skin infections (HP:0001581)2.74651799
26Anorexia (HP:0002039)2.74574690
27Meckel diverticulum (HP:0002245)2.74196821
28Severe visual impairment (HP:0001141)2.72196500
29Ileus (HP:0002595)2.71854025
30Abnormality of the preputium (HP:0100587)2.70837335
31Retrobulbar optic neuritis (HP:0100654)2.70205837
32Optic neuritis (HP:0100653)2.70205837
33Hemorrhage of the eye (HP:0011885)2.68967197
34Hypophosphatemic rickets (HP:0004912)2.68812875
35Pustule (HP:0200039)2.67506750
36Hypertriglyceridemia (HP:0002155)2.65253325
37Syringomyelia (HP:0003396)2.64429249
38Spinal cord lesions (HP:0100561)2.64429249
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.63426721
40Abnormality of the ileum (HP:0001549)2.63256084
41Abnormality of chromosome stability (HP:0003220)2.62406078
42Panhypogammaglobulinemia (HP:0003139)2.58453349
43Rickets (HP:0002748)2.56890034
44Rectal prolapse (HP:0002035)2.56777216
45Acute myeloid leukemia (HP:0004808)2.54541295
46Gingival bleeding (HP:0000225)2.52496737
47Myelodysplasia (HP:0002863)2.47741875
48Joint hemorrhage (HP:0005261)2.45733415
49Poikilocytosis (HP:0004447)2.45139977
50Ulnar bowing (HP:0003031)2.44445863
51Cellulitis (HP:0100658)2.44261551
52Clubbing of toes (HP:0100760)2.42720368
53Recurrent fungal infections (HP:0002841)2.42351931
54Osteomalacia (HP:0002749)2.39715188
55Flattened epiphyses (HP:0003071)2.39013603
56Arterial thrombosis (HP:0004420)2.38213548
57Urticaria (HP:0001025)2.37228137
58Episodic fever (HP:0001954)2.36939080
59Cheilitis (HP:0100825)2.35536859
60Abnormal spermatogenesis (HP:0008669)2.33273882
61Deep venous thrombosis (HP:0002625)2.33005268
62Segmental peripheral demyelination/remyelination (HP:0003481)2.29897578
63Amyloidosis (HP:0011034)2.29739282
64Abnormality of chloride homeostasis (HP:0011422)2.29328943
65Myositis (HP:0100614)2.29053006
66Prominent nose (HP:0000448)2.28183179
67Abnormal hair whorl (HP:0010721)2.25816916
68Chest pain (HP:0100749)2.24412948
69Widely patent fontanelles and sutures (HP:0004492)2.24126954
70Recurrent viral infections (HP:0004429)2.23907176
71Pulmonary embolism (HP:0002204)2.23786132
72Abnormality of T cell number (HP:0011839)2.23615344
73Lip pit (HP:0100267)2.21108519
74IgM deficiency (HP:0002850)2.21004857
75Tented upper lip vermilion (HP:0010804)2.20260342
76T lymphocytopenia (HP:0005403)2.20091384
77Autoimmune thrombocytopenia (HP:0001973)2.19886919
78Abnormality of alkaline phosphatase activity (HP:0004379)2.18043157
79Arthropathy (HP:0003040)2.16674539
80Prostate neoplasm (HP:0100787)2.16340920
81Abnormality of the intervertebral disk (HP:0005108)2.13986482
82Volvulus (HP:0002580)2.13445422
83Recurrent abscess formation (HP:0002722)2.13145611
84Abnormality of the common coagulation pathway (HP:0010990)2.11825608
85Lymphopenia (HP:0001888)2.11116702
86Abnormal enzyme/coenzyme activity (HP:0012379)2.10997963
87Keratitis (HP:0000491)2.10962210
88Abnormality of the carotid arteries (HP:0005344)2.10535890
89Abnormality of the peritoneum (HP:0002585)2.10469604
90Duodenal stenosis (HP:0100867)2.10463463
91Small intestinal stenosis (HP:0012848)2.10463463
92Glomerulopathy (HP:0100820)2.10072308
93Intestinal atresia (HP:0011100)2.09655701
94Abnormality of the costochondral junction (HP:0000919)2.09572028
95Increased IgM level (HP:0003496)2.09180745
96Resting tremor (HP:0002322)2.09034822
97Agammaglobulinemia (HP:0004432)2.08545862
98Febrile seizures (HP:0002373)2.08169732
99Vaginal fistula (HP:0004320)2.06571087
100IgA deficiency (HP:0002720)2.06167622
101Recurrent pneumonia (HP:0006532)2.05322430
102Orchitis (HP:0100796)2.04936894
103Mediastinal lymphadenopathy (HP:0100721)2.04684082
104Abnormality of cells of the lymphoid lineage (HP:0012140)2.04123195
105Eczematoid dermatitis (HP:0000976)2.03674567
106Renal cortical cysts (HP:0000803)2.02432108
107Elevated alkaline phosphatase (HP:0003155)2.01948663
108Severe combined immunodeficiency (HP:0004430)2.00769818
109Nephroblastoma (Wilms tumor) (HP:0002667)2.00765673
110Hemoptysis (HP:0002105)2.00153382
111Small epiphyses (HP:0010585)2.00136311
112Patellar aplasia (HP:0006443)1.99657810
113Abnormality of DNA repair (HP:0003254)1.99523691
114Abnormality of the prostate (HP:0008775)1.99326124
115Spontaneous hematomas (HP:0007420)1.97987255
116Encephalitis (HP:0002383)1.97430514
117Recurrent cutaneous fungal infections (HP:0011370)1.97292060
118Chronic mucocutaneous candidiasis (HP:0002728)1.97292060
119Embryonal renal neoplasm (HP:0011794)1.97006244
120Petechiae (HP:0000967)1.96628684
121Optic nerve coloboma (HP:0000588)1.96621084
122B lymphocytopenia (HP:0010976)1.95892805
123Abnormality of B cell number (HP:0010975)1.95892805
124Deep philtrum (HP:0002002)1.95843687
125Slow saccadic eye movements (HP:0000514)1.95334825
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95042403
127Intestinal fistula (HP:0100819)1.94808669
128Bone marrow hypocellularity (HP:0005528)1.94197042
129Lymphoma (HP:0002665)1.94091450
130Stomach cancer (HP:0012126)1.93615092
131Abnormal pancreas size (HP:0012094)1.93414842
132Chronic diarrhea (HP:0002028)1.92466616
133Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92094075
134Upper motor neuron abnormality (HP:0002127)1.91048579
135Abnormality of the duodenum (HP:0002246)1.90131084
136Mitral stenosis (HP:0001718)1.88935123
137Myocardial infarction (HP:0001658)1.87943796
138Aplasia/Hypoplasia of the patella (HP:0006498)1.86653548
139Impulsivity (HP:0100710)1.86271976
140Abnormality of T cells (HP:0002843)1.85689216
141Enlarged epiphyses (HP:0010580)1.85649654
142Recurrent bacterial skin infections (HP:0005406)1.84900472
143Epistaxis (HP:0000421)1.84872937
144Prolonged bleeding time (HP:0003010)1.82629989
145Breast hypoplasia (HP:0003187)1.82244324
146Microcytic anemia (HP:0001935)1.82045329
147Distal lower limb muscle weakness (HP:0009053)1.81577473
148Abnormality of the endocardium (HP:0004306)1.81322449
149Spontaneous abortion (HP:0005268)1.81097389
150Thrombocytosis (HP:0001894)1.80314552
151Aplastic anemia (HP:0001915)1.79833141
152IgG deficiency (HP:0004315)1.79552272
153Vertebral arch anomaly (HP:0008438)1.79166253
154Nasal polyposis (HP:0100582)1.78501432
155Anal stenosis (HP:0002025)1.77669548
156Stomatitis (HP:0010280)1.77121111
157Absent epiphyses (HP:0010577)1.76540109
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76540109
159Bony spicule pigmentary retinopathy (HP:0007737)1.75469772
160Prolonged partial thromboplastin time (HP:0003645)1.75030354
161Thin bony cortex (HP:0002753)1.74061812
162Abnormality of the nasal septum (HP:0000419)1.73714822
163Meningitis (HP:0001287)1.72535326
164Duplicated collecting system (HP:0000081)1.72293196
165Vasculitis (HP:0002633)1.71456363
166Keratoconjunctivitis sicca (HP:0001097)1.71338652
167Combined immunodeficiency (HP:0005387)1.70288251
168Infertility (HP:0000789)1.70182441
169Basal cell carcinoma (HP:0002671)1.70026933
170Alveolar cell carcinoma (HP:0006519)1.69973832
171Osteomyelitis (HP:0002754)1.69917550

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.65092075
2ERN13.44814276
3ZAK3.35853519
4LMTK23.13999591
5MAP3K143.05215633
6TXK2.99463624
7IRAK42.97112607
8MAP4K12.79608004
9EPHB12.51773469
10IRAK32.37310652
11PLK42.34951470
12KSR22.25997372
13CSK2.20411788
14BLK2.14489001
15JAK32.10615873
16CDK122.09953033
17CHUK1.98760365
18IKBKB1.97426713
19BRD41.97129841
20ACVR1B1.91098832
21WNK41.90988436
22PRPF4B1.87796277
23TAOK11.84067420
24FES1.83235631
25MKNK21.81877416
26STK241.81196995
27TRIB31.76968833
28SIK21.71206375
29STK41.65741057
30SMG11.63551609
31STK381.62024844
32CDK81.61767132
33EIF2AK21.59815878
34PIM11.59729057
35STK31.57507467
36TSSK61.55882771
37TNK21.49327159
38LATS11.47528077
39CLK11.46492948
40IKBKE1.46362037
41SIK11.42100282
42WNK11.41897566
43SRPK11.41338377
44NEK21.40927256
45TGFBR11.40375329
46PIM21.40184431
47FGR1.40148481
48PDPK11.40069394
49TEC1.37679724
50ICK1.36881675
51MAP3K111.34586409
52MARK21.31353119
53NEK61.29898838
54STK101.28452599
55PRKG21.26803518
56SGK21.25821412
57PDK11.25741437
58MELK1.25103804
59MKNK11.24832731
60AKT31.24791621
61MAP3K11.22244090
62PASK1.21715317
63MAP3K91.20343544
64ZAP701.20333549
65IRAK21.18979706
66CAMK1G1.18944962
67ATR1.17664435
68DYRK1B1.15197883
69BMPR1B1.10941794
70JAK21.10807906
71STK38L1.09513994
72TESK21.07277425
73NME21.06627129
74BMPR21.06419772
75PTK61.06208853
76ERBB31.03085799
77TYK21.02223956
78EPHA21.00560391
79CAMK1D1.00087820
80TTK0.99205031
81RAF10.98947919
82BRAF0.98701623
83SGK30.98378582
84BTK0.98217717
85OXSR10.97412658
86FGFR40.97175304
87CDC70.95287430
88TYRO30.94126969
89YES10.92413092
90NLK0.90951157
91MAP3K130.87900020
92IRAK10.85399000
93SYK0.83679126
94TAOK20.83536063
95MARK30.82123227
96MAP3K20.82022969
97EIF2AK10.81970604
98CHEK10.81454040
99TIE10.80730825
100CDK90.80219975
101STK110.77788515
102BMX0.76810758
103NUAK10.76676987
104LCK0.74531316
105CDK40.74486253
106PRKCH0.72815917
107PLK30.72065959
108FRK0.71402318
109HCK0.70258401
110MAP2K30.69647786
111TRPM70.67979021
112ARAF0.66958578
113CHEK20.66340955
114PTK2B0.66312133
115ATM0.66225992
116MAP3K70.65976137
117TAOK30.64588918
118JAK10.64467429
119TBK10.63493776
120DYRK30.63389746
121PRKAA20.63345260
122LYN0.62160640
123CDK190.61405530
124VRK10.60959015
125AURKB0.60832962
126TESK10.59237383
127GRK60.58268331
128CDK70.57433150
129FGFR30.57182172
130PDGFRB0.54610137
131MAP2K40.52930207
132RPS6KA40.52291124
133NEK90.52282397
134FLT30.51944193
135RPS6KB10.50294754
136PLK10.49471831
137MAP3K30.49195744
138PRKCZ0.48596583
139EIF2AK30.48574860
140MAP3K80.48308683
141MAP3K100.48127455
142RPS6KL10.48077155
143RPS6KA10.47281337
144CDK20.46436098
145RPS6KA60.45461737
146PLK20.44620413
147CDC42BPA0.44509147
148DDR20.43915153
149STK390.43832731
150CSF1R0.43208050
151BRSK10.43100725
152PDK20.42833058
153MTOR0.42641491
154RPS6KA50.42456890
155PIK3CA0.42321339
156SIK30.41999046
157RIPK10.41652088
158PRKD20.41623110
159BRSK20.40969359
160RET0.40574088
161INSRR0.39741780
162ALK0.39651886
163ITK0.39295370
164MAP3K50.39050435
165RPS6KC10.38986778
166PRKCQ0.37446944
167RPS6KA20.34976597

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.52098540
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.46863162
3Fanconi anemia pathway_Homo sapiens_hsa034602.41115111
4Primary immunodeficiency_Homo sapiens_hsa053402.40766009
5Fatty acid biosynthesis_Homo sapiens_hsa000612.27867131
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23926905
7Mismatch repair_Homo sapiens_hsa034302.22282458
8Staphylococcus aureus infection_Homo sapiens_hsa051502.22273168
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18635042
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.13568449
11Sulfur relay system_Homo sapiens_hsa041222.10803779
12Cell cycle_Homo sapiens_hsa041102.10019315
13Measles_Homo sapiens_hsa051622.07896323
14Base excision repair_Homo sapiens_hsa034102.07765496
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.07286103
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.07087403
17Allograft rejection_Homo sapiens_hsa053302.02614887
18Non-homologous end-joining_Homo sapiens_hsa034501.91847122
19Homologous recombination_Homo sapiens_hsa034401.80547031
20One carbon pool by folate_Homo sapiens_hsa006701.80290054
21Herpes simplex infection_Homo sapiens_hsa051681.78364004
22RNA polymerase_Homo sapiens_hsa030201.76245528
23Graft-versus-host disease_Homo sapiens_hsa053321.75421385
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.69712926
25VEGF signaling pathway_Homo sapiens_hsa043701.67101661
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64708981
27p53 signaling pathway_Homo sapiens_hsa041151.59909161
28Nucleotide excision repair_Homo sapiens_hsa034201.59069294
29Leishmaniasis_Homo sapiens_hsa051401.58845704
30Hematopoietic cell lineage_Homo sapiens_hsa046401.56115227
31Spliceosome_Homo sapiens_hsa030401.54724277
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54553865
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52945143
34RNA transport_Homo sapiens_hsa030131.51836310
35Complement and coagulation cascades_Homo sapiens_hsa046101.44813584
36mRNA surveillance pathway_Homo sapiens_hsa030151.43590414
37T cell receptor signaling pathway_Homo sapiens_hsa046601.36589281
38Autoimmune thyroid disease_Homo sapiens_hsa053201.35489820
39Dorso-ventral axis formation_Homo sapiens_hsa043201.34038543
40Pyrimidine metabolism_Homo sapiens_hsa002401.32626391
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.31361116
42Influenza A_Homo sapiens_hsa051641.30391731
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29074636
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25182027
45Epstein-Barr virus infection_Homo sapiens_hsa051691.22476812
46RNA degradation_Homo sapiens_hsa030181.21980698
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.20490582
48Legionellosis_Homo sapiens_hsa051341.19123991
49Basal transcription factors_Homo sapiens_hsa030221.17968620
50Type II diabetes mellitus_Homo sapiens_hsa049301.17758217
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16349439
52Antigen processing and presentation_Homo sapiens_hsa046121.15360266
53Insulin signaling pathway_Homo sapiens_hsa049101.14482345
54Type I diabetes mellitus_Homo sapiens_hsa049401.13977611
55Insulin resistance_Homo sapiens_hsa049311.11356402
56B cell receptor signaling pathway_Homo sapiens_hsa046621.10655901
57HTLV-I infection_Homo sapiens_hsa051661.10096585
58mTOR signaling pathway_Homo sapiens_hsa041501.09775630
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09722349
60PPAR signaling pathway_Homo sapiens_hsa033201.06421401
61Acute myeloid leukemia_Homo sapiens_hsa052211.06410956
62Endocytosis_Homo sapiens_hsa041441.04432233
63Toxoplasmosis_Homo sapiens_hsa051451.04383895
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04230160
65Asthma_Homo sapiens_hsa053101.04159132
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03230211
67Hepatitis B_Homo sapiens_hsa051611.03149369
68Other glycan degradation_Homo sapiens_hsa005111.02425786
69Apoptosis_Homo sapiens_hsa042101.02255411
70Viral carcinogenesis_Homo sapiens_hsa052031.00524669
71Systemic lupus erythematosus_Homo sapiens_hsa053221.00468362
72Osteoclast differentiation_Homo sapiens_hsa043800.99075000
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97896469
74Renal cell carcinoma_Homo sapiens_hsa052110.95691392
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94337895
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94000061
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93312933
78Chronic myeloid leukemia_Homo sapiens_hsa052200.92133771
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91924297
80TNF signaling pathway_Homo sapiens_hsa046680.90698395
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90019167
82Lysine degradation_Homo sapiens_hsa003100.88456514
83Vitamin B6 metabolism_Homo sapiens_hsa007500.86535592
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84982597
85ErbB signaling pathway_Homo sapiens_hsa040120.82381682
86Pertussis_Homo sapiens_hsa051330.82345083
87Phagosome_Homo sapiens_hsa041450.78909445
88Viral myocarditis_Homo sapiens_hsa054160.77710130
89AMPK signaling pathway_Homo sapiens_hsa041520.77353646
90African trypanosomiasis_Homo sapiens_hsa051430.76202473
91Small cell lung cancer_Homo sapiens_hsa052220.75995633
92MAPK signaling pathway_Homo sapiens_hsa040100.75693516
93FoxO signaling pathway_Homo sapiens_hsa040680.75452042
94MicroRNAs in cancer_Homo sapiens_hsa052060.75328706
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74095014
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73541384
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73136845
98Purine metabolism_Homo sapiens_hsa002300.72331898
99Inositol phosphate metabolism_Homo sapiens_hsa005620.71527387
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70826755
101Prolactin signaling pathway_Homo sapiens_hsa049170.69428123
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.67822273
103Choline metabolism in cancer_Homo sapiens_hsa052310.67104658
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65867522
105Bladder cancer_Homo sapiens_hsa052190.65750134
106Notch signaling pathway_Homo sapiens_hsa043300.65626028
107Malaria_Homo sapiens_hsa051440.65010865
108Hepatitis C_Homo sapiens_hsa051600.64697492
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.63918733
110Chemokine signaling pathway_Homo sapiens_hsa040620.63112757
111Regulation of autophagy_Homo sapiens_hsa041400.62686919
112Shigellosis_Homo sapiens_hsa051310.61616993
113Tuberculosis_Homo sapiens_hsa051520.59987574
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59389411
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.57520276
116Prostate cancer_Homo sapiens_hsa052150.56414115
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56344083
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53632202
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53614893
120Rheumatoid arthritis_Homo sapiens_hsa053230.53499754
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53158347
122* Phenylalanine metabolism_Homo sapiens_hsa003600.52404824
123Thyroid cancer_Homo sapiens_hsa052160.51297960
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50848996
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50528497
126Bile secretion_Homo sapiens_hsa049760.48035243
127Non-small cell lung cancer_Homo sapiens_hsa052230.47058076
128Glycerolipid metabolism_Homo sapiens_hsa005610.46870946
129Pancreatic cancer_Homo sapiens_hsa052120.46094744
130Platelet activation_Homo sapiens_hsa046110.45894358
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44910526
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44649237
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44490829
134Colorectal cancer_Homo sapiens_hsa052100.41497425
135Endometrial cancer_Homo sapiens_hsa052130.39505168
136HIF-1 signaling pathway_Homo sapiens_hsa040660.38146986
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.37938123
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.35930839
139Ribosome_Homo sapiens_hsa030100.34083398
140TGF-beta signaling pathway_Homo sapiens_hsa043500.31717399
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27859144
142ABC transporters_Homo sapiens_hsa020100.27039501
143Pathways in cancer_Homo sapiens_hsa052000.25622941
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25138574
145Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24324248

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