AOC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.72961946
2intestinal cholesterol absorption (GO:0030299)9.35309715
3angiotensin maturation (GO:0002003)8.91242559
4regulation of guanylate cyclase activity (GO:0031282)7.42574537
5NADH metabolic process (GO:0006734)6.35046781
6negative regulation of complement activation (GO:0045916)6.34190119
7epoxygenase P450 pathway (GO:0019373)6.02159585
8virion attachment to host cell (GO:0019062)5.90896892
9adhesion of symbiont to host cell (GO:0044650)5.90896892
10fat-soluble vitamin biosynthetic process (GO:0042362)5.82739793
11actin filament depolymerization (GO:0030042)5.69232672
12vitamin A metabolic process (GO:0006776)5.65549300
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.58344134
14positive regulation of guanylate cyclase activity (GO:0031284)5.56341773
15bundle of His cell to Purkinje myocyte communication (GO:0086069)5.21896408
16negative regulation of protein activation cascade (GO:2000258)5.19617798
17flavonoid metabolic process (GO:0009812)5.02958682
18regulation of cellular extravasation (GO:0002691)5.02843205
19fructose metabolic process (GO:0006000)4.95909158
20regulation of systemic arterial blood pressure (GO:0003073)4.88460396
21adhesion of symbiont to host (GO:0044406)4.83206872
22maintenance of gastrointestinal epithelium (GO:0030277)4.73823621
23regulation of bile acid biosynthetic process (GO:0070857)4.72699946
24digestive system process (GO:0022600)4.67065460
25positive regulation of respiratory burst (GO:0060267)4.64461844
26renal system process involved in regulation of blood volume (GO:0001977)4.54960415
27regulation of cGMP biosynthetic process (GO:0030826)4.54906361
28receptor guanylyl cyclase signaling pathway (GO:0007168)4.52443265
29UDP-N-acetylglucosamine metabolic process (GO:0006047)4.50511098
30cellular glucuronidation (GO:0052695)4.50347541
31regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.46971216
32uronic acid metabolic process (GO:0006063)4.41800364
33glucuronate metabolic process (GO:0019585)4.41800364
34drug metabolic process (GO:0017144)4.41798156
35negative regulation of humoral immune response (GO:0002921)4.36683086
36drug catabolic process (GO:0042737)4.23947043
37phospholipid efflux (GO:0033700)4.23331101
38regulation of vitamin metabolic process (GO:0030656)4.15149420
39positive regulation of pseudopodium assembly (GO:0031274)4.14281199
40regulation of cholesterol esterification (GO:0010872)4.09260077
41purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.07886578
423-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.07886578
43positive regulation of triglyceride lipase activity (GO:0061365)4.07133159
44positive regulation of lipoprotein lipase activity (GO:0051006)4.07133159
45urea cycle (GO:0000050)4.05241502
46plasma lipoprotein particle assembly (GO:0034377)4.01234670
47bile acid and bile salt transport (GO:0015721)3.96182560
48epithelial structure maintenance (GO:0010669)3.92470068
49glycosphingolipid catabolic process (GO:0046479)3.91601447
50glycolipid catabolic process (GO:0019377)3.90853908
51hydrogen peroxide catabolic process (GO:0042744)3.87212637
52cellular response to hepatocyte growth factor stimulus (GO:0035729)3.87054782
53response to hepatocyte growth factor (GO:0035728)3.87054782
54vitamin transmembrane transport (GO:0035461)3.86575989
55urea metabolic process (GO:0019627)3.84804861
56modified amino acid transport (GO:0072337)3.84305856
57sulfate transmembrane transport (GO:1902358)3.82711672
58lipoprotein metabolic process (GO:0042157)3.81627447
59protein-lipid complex assembly (GO:0065005)3.79875496
60regulation of cGMP metabolic process (GO:0030823)3.76557089
61response to hydroperoxide (GO:0033194)3.76538504
62regulation of triglyceride catabolic process (GO:0010896)3.73708519
63regulation of pseudopodium assembly (GO:0031272)3.70168580
64glucose 6-phosphate metabolic process (GO:0051156)3.67316801
65triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.60742053
66digestion (GO:0007586)3.55282353
67nitrogen cycle metabolic process (GO:0071941)3.54214409
68peptide catabolic process (GO:0043171)3.52821060
69calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.50409027
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48266561
71glomerular filtration (GO:0003094)3.46514384
72cholesterol homeostasis (GO:0042632)3.45923364
73vitamin transport (GO:0051180)3.45893987
74cholesterol efflux (GO:0033344)3.44980665
75hormone catabolic process (GO:0042447)3.44759482
76sterol homeostasis (GO:0055092)3.43917430
77alkaloid metabolic process (GO:0009820)3.43788799
78cGMP-mediated signaling (GO:0019934)3.41087506
79nucleoside diphosphate biosynthetic process (GO:0009133)3.37517653
80peptide hormone processing (GO:0016486)3.37247678
81regulation of respiratory burst (GO:0060263)3.37048944
82very-low-density lipoprotein particle assembly (GO:0034379)3.36213873
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35985088
84embryonic digestive tract development (GO:0048566)3.34423383
85cellular response to nitric oxide (GO:0071732)3.32229397
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31227927
87transcytosis (GO:0045056)3.30753008
88O-glycan processing (GO:0016266)3.28825164
89positive regulation of glycoprotein biosynthetic process (GO:0010560)3.28369932
90diol metabolic process (GO:0034311)3.26006323
91positive regulation of cGMP biosynthetic process (GO:0030828)3.25115884
92sulfur compound transport (GO:0072348)3.24703288
93thrombin receptor signaling pathway (GO:0070493)3.24309726
94thyroid hormone metabolic process (GO:0042403)3.24180794
95regulation of cholesterol homeostasis (GO:2000188)3.23997297
96antigen processing and presentation of endogenous antigen (GO:0019883)3.23596492
97hemidesmosome assembly (GO:0031581)3.23092032
98renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.22310173
99intestinal epithelial cell development (GO:0060576)3.19922097
100positive regulation of p38MAPK cascade (GO:1900745)3.18137566
101lipoprotein transport (GO:0042953)3.17120594
102renal filtration (GO:0097205)3.15454014
103glucocorticoid biosynthetic process (GO:0006704)3.15197189
104diacylglycerol metabolic process (GO:0046339)3.14953672
105ceramide catabolic process (GO:0046514)3.14154948
106glycosylceramide metabolic process (GO:0006677)3.13636770
107homocysteine metabolic process (GO:0050667)3.12621594
108purine nucleotide salvage (GO:0032261)3.11391243
109arginine metabolic process (GO:0006525)3.11270818
110cholesterol transport (GO:0030301)3.09267513
111sterol transport (GO:0015918)3.09267513
112ethanol oxidation (GO:0006069)3.08788617
113response to nitric oxide (GO:0071731)3.07878763
114positive regulation of glycoprotein metabolic process (GO:1903020)3.07165915
115fat-soluble vitamin metabolic process (GO:0006775)3.06819410
116protein kinase C signaling (GO:0070528)3.05312966
117positive regulation of lipid catabolic process (GO:0050996)3.04542722
118sphingolipid catabolic process (GO:0030149)3.04014461
119oligosaccharide biosynthetic process (GO:0009312)3.03514353
120auditory receptor cell differentiation (GO:0042491)3.03342204
121transepithelial transport (GO:0070633)3.02647988
122sulfate transport (GO:0008272)3.01885025
123cGMP biosynthetic process (GO:0006182)3.01720826
124cellular response to reactive nitrogen species (GO:1902170)3.01173734
125drug transmembrane transport (GO:0006855)2.99665937
126glycerol metabolic process (GO:0006071)2.99581293
127glutamine family amino acid biosynthetic process (GO:0009084)2.99528541
128exogenous drug catabolic process (GO:0042738)2.99172421
129drinking behavior (GO:0042756)2.94554267
130sphingoid metabolic process (GO:0046519)2.93586073
131positive regulation of fatty acid biosynthetic process (GO:0045723)2.92745719
132regulation of systemic arterial blood pressure by hormone (GO:0001990)2.91320582
133regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.91320582
134endocrine process (GO:0050886)2.91320582
135negative regulation of cholesterol transport (GO:0032375)2.88917611
136negative regulation of sterol transport (GO:0032372)2.88917611
137bicarbonate transport (GO:0015701)2.88764616
138reverse cholesterol transport (GO:0043691)2.85949913
139regulation of Golgi to plasma membrane protein transport (GO:0042996)2.81778232
140hydrogen peroxide metabolic process (GO:0042743)2.80255766
141renal absorption (GO:0070293)2.79893454
142sulfation (GO:0051923)2.79191539
143phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.78396513
144sphingomyelin metabolic process (GO:0006684)2.76962542
145oligosaccharide catabolic process (GO:0009313)2.73318657
146innate immune response in mucosa (GO:0002227)2.71785349
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.70691949
148phospholipid homeostasis (GO:0055091)2.70644391
149ventricular cardiac muscle cell action potential (GO:0086005)2.67685435
150regulation of digestive system process (GO:0044058)2.66122453
151epithelial cell-cell adhesion (GO:0090136)2.64121676
152hepatocyte apoptotic process (GO:0097284)2.63243784
153striated muscle atrophy (GO:0014891)2.62919339
154antibacterial humoral response (GO:0019731)2.62318449
155antimicrobial humoral response (GO:0019730)2.59806057
156regulation of macrophage chemotaxis (GO:0010758)2.57491458
157drug transport (GO:0015893)2.57162373
158phospholipid scrambling (GO:0017121)2.57109484
159sperm capacitation (GO:0048240)2.56889714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.27648395
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.41713485
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.69746745
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.08017152
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.96930355
6CDX2_19796622_ChIP-Seq_MESCs_Mouse2.81517163
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.72969441
8GATA4_25053715_ChIP-Seq_YYC3_Human2.66264921
9SOX2_20726797_ChIP-Seq_SW620_Human2.60995803
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.47075908
11GATA6_25053715_ChIP-Seq_YYC3_Human2.29327724
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17974329
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14439825
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.11245605
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.10000851
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08521228
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.06874618
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.02650990
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94275653
20FOXO3_23340844_ChIP-Seq_DLD1_Human1.83254673
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.79470927
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.79391131
23CLOCK_20551151_ChIP-Seq_293T_Human1.76459418
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.74881766
25GATA1_22025678_ChIP-Seq_K562_Human1.65859959
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64565640
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63511331
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63090964
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62780032
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58908228
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58783015
32KLF5_25053715_ChIP-Seq_YYC3_Human1.57107845
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53333008
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.52334392
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.48738135
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48429529
37BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.43713426
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43655590
39RACK7_27058665_Chip-Seq_MCF-7_Human1.39914139
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39435912
41ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38932072
42KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35150090
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34905893
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33885643
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33627611
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32850539
47DROSHA_22980978_ChIP-Seq_HELA_Human1.32070983
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31963151
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31941496
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.31084406
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30250148
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25797673
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.23505892
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23015265
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20763126
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19161444
57BCL6_27268052_Chip-Seq_Bcells_Human1.17208330
58BCOR_27268052_Chip-Seq_Bcells_Human1.17008826
59SA1_27219007_Chip-Seq_Bcells_Human1.16718107
60GATA2_19941826_ChIP-Seq_K562_Human1.16456234
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.15668692
62JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15194526
63BCAT_22108803_ChIP-Seq_LS180_Human1.14088417
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13019871
65FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12825717
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12640557
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.12475115
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.11629335
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.11382770
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.11382770
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08424980
72ZNF263_19887448_ChIP-Seq_K562_Human1.08219121
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07633369
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06236420
75CTCF_27219007_Chip-Seq_Bcells_Human1.06195535
76EGR1_19032775_ChIP-ChIP_M12_Human1.04972208
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04086653
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.02697540
79ATF3_27146783_Chip-Seq_COLON_Human1.01702106
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01214721
81CJUN_26792858_Chip-Seq_BT549_Human1.00526998
82VDR_24763502_ChIP-Seq_THP-1_Human1.00089653
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99623619
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99250783
85FOXA2_19822575_ChIP-Seq_HepG2_Human0.99037168
86GATA1_19941826_ChIP-Seq_K562_Human0.98786071
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98657380
88EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97021681
89HNF4A_19822575_ChIP-Seq_HepG2_Human0.96205350
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95310549
91RXR_22108803_ChIP-Seq_LS180_Human0.94511318
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94508594
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94352240
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94111888
95NANOG_20526341_ChIP-Seq_ESCs_Human0.94004481
96SMAD3_21741376_ChIP-Seq_HESCs_Human0.93514627
97CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92562113
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92133683
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92103612
100P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92103219
101SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91513539
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91156696
103RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90973570
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90375039
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89720968
106CEBPB_22108803_ChIP-Seq_LS180_Human0.89514845
107STAT1_20625510_ChIP-Seq_HELA_Human0.88731966
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88627801
109HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87877371
110TP63_23658742_ChIP-Seq_EP156T_Human0.87130484
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86750254
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85727630
113GATA3_24758297_ChIP-Seq_MCF-7_Human0.85158129
114CREB1_26743006_Chip-Seq_LNCaP_Human0.85138101
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85132827
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84714796
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.84458568
118TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84239013
119AHR_22903824_ChIP-Seq_MCF-7_Human0.82618826
120IRF8_27001747_Chip-Seq_BMDM_Mouse0.82609503
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.82327960
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80216375
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79590058
124VDR_24787735_ChIP-Seq_THP-1_Human0.79165100
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78317087
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78205869
127FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76220568
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74837188
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72983915
130CDX2_22108803_ChIP-Seq_LS180_Human0.71798980
131TP63_22573176_ChIP-Seq_HFKS_Human0.71529566
132LXR_22292898_ChIP-Seq_THP-1_Human0.71481808
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65590980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.85865112
2MP0001666_abnormal_nutrient_absorption5.06154284
3MP0010234_abnormal_vibrissa_follicle4.82018836
4MP0002254_reproductive_system_inflammat4.57821919
5MP0004264_abnormal_extraembryonic_tissu3.63442377
6MP0009840_abnormal_foam_cell3.03752760
7MP0000462_abnormal_digestive_system2.89286375
8MP0005085_abnormal_gallbladder_physiolo2.88911996
9MP0003183_abnormal_peptide_metabolism2.75738250
10MP0003866_abnormal_defecation2.71325983
11MP0003252_abnormal_bile_duct2.69269376
12MP0005377_hearing/vestibular/ear_phenot2.48825155
13MP0003878_abnormal_ear_physiology2.48825155
14MP0006054_spinal_hemorrhage2.30233970
15MP0002139_abnormal_hepatobiliary_system2.27725403
16MP0000538_abnormal_urinary_bladder2.23545694
17MP0001873_stomach_inflammation2.23252647
18MP0010329_abnormal_lipoprotein_level2.19444802
19MP0005409_darkened_coat_color2.13186808
20MP0008875_abnormal_xenobiotic_pharmacok2.12410626
21MP0001663_abnormal_digestive_system2.10550691
22MP0010352_gastrointestinal_tract_polyps2.07886251
23MP0010155_abnormal_intestine_physiology2.04384178
24MP0002822_catalepsy1.96226040
25MP0005381_digestive/alimentary_phenotyp1.95995674
26MP0003705_abnormal_hypodermis_morpholog1.82882061
27MP0003868_abnormal_feces_composition1.70636133
28MP0000537_abnormal_urethra_morphology1.68862842
29MP0003300_gastrointestinal_ulcer1.66366854
30MP0005084_abnormal_gallbladder_morpholo1.64548266
31MP0001664_abnormal_digestion1.64271618
32MP0004147_increased_porphyrin_level1.62916116
33MP0002876_abnormal_thyroid_physiology1.62083130
34MP0005365_abnormal_bile_salt1.60064573
35MP0000477_abnormal_intestine_morphology1.54657981
36MP0004019_abnormal_vitamin_homeostasis1.53313702
37MP0003191_abnormal_cellular_cholesterol1.48824754
38MP0010678_abnormal_skin_adnexa1.47317794
39MP0005670_abnormal_white_adipose1.45833522
40MP0000490_abnormal_crypts_of1.44581865
41MP0000678_abnormal_parathyroid_gland1.43976264
42MP0002796_impaired_skin_barrier1.41130472
43MP0001764_abnormal_homeostasis1.36555464
44MP0000604_amyloidosis1.34908421
45MP0001188_hyperpigmentation1.33281218
46MP0005310_abnormal_salivary_gland1.31061859
47MP0003950_abnormal_plasma_membrane1.29376243
48MP0002138_abnormal_hepatobiliary_system1.26556948
49MP0009643_abnormal_urine_homeostasis1.26494876
50MP0004782_abnormal_surfactant_physiolog1.20594416
51MP0005167_abnormal_blood-brain_barrier1.17956378
52MP0003724_increased_susceptibility_to1.14427427
53MP0009379_abnormal_foot_pigmentation1.13919212
54MP0004043_abnormal_pH_regulation1.13705638
55MP0003453_abnormal_keratinocyte_physiol1.12884662
56MP0004947_skin_inflammation1.08493880
57MP0001765_abnormal_ion_homeostasis1.01770176
58MP0005451_abnormal_body_composition1.00835412
59MP0001501_abnormal_sleep_pattern0.98592221
60MP0000230_abnormal_systemic_arterial0.97474664
61MP0000685_abnormal_immune_system0.97425489
62MP0005448_abnormal_energy_balance0.96984810
63MP0001849_ear_inflammation0.94090480
64MP0002971_abnormal_brown_adipose0.93903120
65MP0005166_decreased_susceptibility_to0.93197150
66MP0003806_abnormal_nucleotide_metabolis0.93087577
67MP0001346_abnormal_lacrimal_gland0.91121079
68MP0000465_gastrointestinal_hemorrhage0.90287514
69MP0001542_abnormal_bone_strength0.88773345
70MP0002877_abnormal_melanocyte_morpholog0.87685092
71MP0000470_abnormal_stomach_morphology0.87481908
72MP0002089_abnormal_postnatal_growth/wei0.87271030
73MP0005584_abnormal_enzyme/coenzyme_acti0.86787543
74MP0004270_analgesia0.84982589
75MP0005535_abnormal_body_temperature0.84846658
76MP0005319_abnormal_enzyme/_coenzyme0.82807707
77MP0005025_abnormal_response_to0.82219729
78MP0005367_renal/urinary_system_phenotyp0.80455452
79MP0000516_abnormal_urinary_system0.80455452
80MP0005058_abnormal_lysosome_morphology0.80083441
81MP0005501_abnormal_skin_physiology0.79198465
82MP0003436_decreased_susceptibility_to0.77118098
83MP0002118_abnormal_lipid_homeostasis0.76334164
84MP0000609_abnormal_liver_physiology0.75793186
85MP0005332_abnormal_amino_acid0.75063824
86MP0005636_abnormal_mineral_homeostasis0.74818676
87MP0002166_altered_tumor_susceptibility0.74792523
88MP0009053_abnormal_anal_canal0.73922554
89MP0002136_abnormal_kidney_physiology0.73430543
90MP0008469_abnormal_protein_level0.72671604
91MP0003718_maternal_effect0.72149235
92MP0000613_abnormal_salivary_gland0.71823913
93MP0000467_abnormal_esophagus_morphology0.71680981
94MP0005387_immune_system_phenotype0.71204109
95MP0001790_abnormal_immune_system0.71204109
96MP0008872_abnormal_physiological_respon0.70991381
97MP0001216_abnormal_epidermal_layer0.70968579
98MP0006138_congestive_heart_failure0.70740507
99MP0000383_abnormal_hair_follicle0.70020938
100MP0005666_abnormal_adipose_tissue0.69652227
101MP0005164_abnormal_response_to0.69529343
102MP0001835_abnormal_antigen_presentation0.68691951
103MP0009642_abnormal_blood_homeostasis0.66360664
104MP0002098_abnormal_vibrissa_morphology0.63324431
105MP0003283_abnormal_digestive_organ0.62531852
106MP0006082_CNS_inflammation0.62016101
107MP0001845_abnormal_inflammatory_respons0.61650265
108MP0003329_amyloid_beta_deposits0.60988161
109MP0003303_peritoneal_inflammation0.60009333
110MP0000377_abnormal_hair_follicle0.59945204
111MP0005023_abnormal_wound_healing0.59649694
112MP0002896_abnormal_bone_mineralization0.57597460
113MP0009764_decreased_sensitivity_to0.56870304
114MP0001348_abnormal_lacrimal_gland0.56579327
115MP0001881_abnormal_mammary_gland0.56186781
116MP0002148_abnormal_hypersensitivity_rea0.54694164
117MP0005165_increased_susceptibility_to0.54405872
118MP0009333_abnormal_splenocyte_physiolog0.54200443
119MP0002998_abnormal_bone_remodeling0.53823968
120MP0003091_abnormal_cell_migration0.52951893
121MP0000566_synostosis0.52886834
122MP0008004_abnormal_stomach_pH0.50707352
123MP0009115_abnormal_fat_cell0.50161609
124MP0003953_abnormal_hormone_level0.50106206
125MP0009785_altered_susceptibility_to0.49971006
126MP0002277_abnormal_respiratory_mucosa0.49753471
127MP0002060_abnormal_skin_morphology0.49228382
128MP0001485_abnormal_pinna_reflex0.49075992
129MP0001756_abnormal_urination0.47843322
130MP0004858_abnormal_nervous_system0.47784839
131MP0003638_abnormal_response/metabolism_0.47558304
132MP0001533_abnormal_skeleton_physiology0.46848524
133MP0002837_dystrophic_cardiac_calcinosis0.46209451
134MP0000249_abnormal_blood_vessel0.45905182
135MP0003879_abnormal_hair_cell0.45842844
136MP0000681_abnormal_thyroid_gland0.45533744

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.93121012
2Right ventricular cardiomyopathy (HP:0011663)7.35265981
3Abnormality of glutamine family amino acid metabolism (HP:0010902)7.20867597
4Hydroxyprolinuria (HP:0003080)7.20002940
5Abnormality of proline metabolism (HP:0010907)7.20002940
6Decreased circulating renin level (HP:0003351)5.18684389
7Malnutrition (HP:0004395)4.65360363
8Hypobetalipoproteinemia (HP:0003563)4.39050548
9Acanthocytosis (HP:0001927)4.32929182
10Conjugated hyperbilirubinemia (HP:0002908)4.29878722
11Autoimmune thrombocytopenia (HP:0001973)4.10461317
12Alkalosis (HP:0001948)4.06473325
13Abnormality of vitamin metabolism (HP:0100508)3.56375802
14Fat malabsorption (HP:0002630)3.48137105
15Hyperactive renin-angiotensin system (HP:0000841)3.39005653
16Abdominal distention (HP:0003270)3.22085321
17Rectal prolapse (HP:0002035)3.21401744
18Autoimmune hemolytic anemia (HP:0001890)3.19112507
19Cupped ribs (HP:0000887)3.17763449
20Nausea (HP:0002018)3.11192633
21Proximal tubulopathy (HP:0000114)3.02194158
22Chronic diarrhea (HP:0002028)2.92438805
23Systemic lupus erythematosus (HP:0002725)2.86857217
24Osteolytic defects of the hand bones (HP:0009699)2.86072832
25Osteolytic defects of the phalanges of the hand (HP:0009771)2.86072832
26Widely patent fontanelles and sutures (HP:0004492)2.80688725
27Hypolipoproteinemia (HP:0010981)2.80005776
28Eczematoid dermatitis (HP:0000976)2.79247083
29Gastrointestinal dysmotility (HP:0002579)2.78569115
30Hemorrhage of the eye (HP:0011885)2.78106689
31Congenital sensorineural hearing impairment (HP:0008527)2.76728095
32Abnormality of chloride homeostasis (HP:0011422)2.73346617
33Abnormality of glycine metabolism (HP:0010895)2.72379831
34Abnormality of serine family amino acid metabolism (HP:0010894)2.72379831
35Abnormality of the gastric mucosa (HP:0004295)2.69454607
36Hypotension (HP:0002615)2.66734745
37Abnormality of purine metabolism (HP:0004352)2.64413513
38Hypophosphatemia (HP:0002148)2.62872057
39Poikilocytosis (HP:0004447)2.62103098
40Pili torti (HP:0003777)2.60354370
41Focal segmental glomerulosclerosis (HP:0000097)2.56445370
42Intrahepatic cholestasis (HP:0001406)2.55551058
43Ridged nail (HP:0001807)2.54464905
44Flat acetabular roof (HP:0003180)2.52436066
45Pustule (HP:0200039)2.51927967
46Hypokalemia (HP:0002900)2.50747135
47Enlarged epiphyses (HP:0010580)2.47444841
48Confusion (HP:0001289)2.46359977
49Mildly elevated creatine phosphokinase (HP:0008180)2.45329513
50Increased mean platelet volume (HP:0011877)2.45240132
51Limb-girdle muscle atrophy (HP:0003797)2.44661017
52Megaloblastic anemia (HP:0001889)2.43937421
53Pigmentary retinal degeneration (HP:0001146)2.43202732
54Hyperammonemia (HP:0001987)2.41639467
55Dehydration (HP:0001944)2.41074345
56Posterior subcapsular cataract (HP:0007787)2.40458457
57Abnormality of small intestinal villus morphology (HP:0011472)2.40409179
58Villous atrophy (HP:0011473)2.40409179
59Increased IgE level (HP:0003212)2.40029726
60Metabolic alkalosis (HP:0200114)2.39241236
61Persistence of primary teeth (HP:0006335)2.38118098
62Cheilitis (HP:0100825)2.33287699
63Neonatal short-limb short stature (HP:0008921)2.32887938
64Steatorrhea (HP:0002570)2.31953310
65Spondylolisthesis (HP:0003302)2.31418398
66Gout (HP:0001997)2.31217960
67Abnormal biliary tract morphology (HP:0012440)2.30085148
68Syncope (HP:0001279)2.29541465
69Absent frontal sinuses (HP:0002688)2.26760083
70Protuberant abdomen (HP:0001538)2.23274316
71Delayed epiphyseal ossification (HP:0002663)2.22979471
72Milia (HP:0001056)2.22867017
73Fragile skin (HP:0001030)2.22420602
74Abnormality of magnesium homeostasis (HP:0004921)2.20610409
75Abnormal hemoglobin (HP:0011902)2.20276912
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.17930555
77Abnormal urine phosphate concentration (HP:0012599)2.16611775
78Biliary tract neoplasm (HP:0100574)2.15311524
79Renal tubular acidosis (HP:0001947)2.14606436
80Hyperaldosteronism (HP:0000859)2.14452562
81Hyperglycinuria (HP:0003108)2.13361794
82Abnormality of potassium homeostasis (HP:0011042)2.11931406
83Abnormality of the vitamin B12 metabolism (HP:0004341)2.11652339
84Cerebral palsy (HP:0100021)2.10403866
85Palpitations (HP:0001962)2.09743949
86Nephrolithiasis (HP:0000787)2.08158356
87Abnormal platelet volume (HP:0011876)2.07457933
88Xanthomatosis (HP:0000991)2.06942829
89Glomerulonephritis (HP:0000099)2.06444124
90Myopathic facies (HP:0002058)2.06069412
91Abnormality of the costochondral junction (HP:0000919)2.05311145
92Atrophic scars (HP:0001075)2.04927095
93Hyperphosphaturia (HP:0003109)2.03602648
94Potter facies (HP:0002009)2.03411516
95Facial shape deformation (HP:0011334)2.03411516
96Woolly hair (HP:0002224)2.03138856
97Metabolic acidosis (HP:0001942)2.02772380
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02463193
99Dicarboxylic aciduria (HP:0003215)2.02463193
100Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01840201
101Hyponatremia (HP:0002902)2.01431953
102Glomerulosclerosis (HP:0000096)2.00911352
103Mesangial abnormality (HP:0001966)1.99735267
104Reticulocytosis (HP:0001923)1.98627196
105Plantar hyperkeratosis (HP:0007556)1.97830789
106Growth hormone excess (HP:0000845)1.96731693
107Ventricular fibrillation (HP:0001663)1.95690180
108Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.93927280
109Abnormality of vitamin B metabolism (HP:0004340)1.92223880
110Abnormality of complement system (HP:0005339)1.91563891
111Subcapsular cataract (HP:0000523)1.91174566
112Abnormality of the distal phalanx of the thumb (HP:0009617)1.91048747
113Gingivitis (HP:0000230)1.90532207
114Abnormality of urine glucose concentration (HP:0011016)1.90419538
115Glycosuria (HP:0003076)1.90419538
116Hyperphosphatemia (HP:0002905)1.89662444
117Abnormal glucose tolerance (HP:0001952)1.89163264
118Abnormality of the 1st metacarpal (HP:0010009)1.88820689
119Hyperuricemia (HP:0002149)1.88541085
120Increased purine levels (HP:0004368)1.88541085
121Abnormal tarsal ossification (HP:0008369)1.87730456
122Cervical subluxation (HP:0003308)1.86444187
123Segmental peripheral demyelination/remyelination (HP:0003481)1.86408534
124Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.86378419
125Vertebral hypoplasia (HP:0008417)1.86378419
126Complement deficiency (HP:0004431)1.84109085
127Adrenal overactivity (HP:0002717)1.84103566
128Hyperparathyroidism (HP:0000843)1.83725399
129Petechiae (HP:0000967)1.83170286
130Nephritis (HP:0000123)1.82514914
131Nasal polyposis (HP:0100582)1.81609829
132Abnormal hair laboratory examination (HP:0003328)1.78900697
133Abnormality of nucleobase metabolism (HP:0010932)1.77278846
134Progressive sensorineural hearing impairment (HP:0000408)1.76478298
135Polycythemia (HP:0001901)1.75661962
136Multiple lipomas (HP:0001012)1.75642331
137Hyporeflexia of lower limbs (HP:0002600)1.75540804
138Urinary glycosaminoglycan excretion (HP:0003541)1.75520762
139Mucopolysacchariduria (HP:0008155)1.75520762
140Thin bony cortex (HP:0002753)1.75137864
141Epidermoid cyst (HP:0200040)1.74317721
142Abnormality of renin-angiotensin system (HP:0000847)1.70848147
143Wide cranial sutures (HP:0010537)1.70765406
144Micronodular cirrhosis (HP:0001413)1.69520054
145Pancreatitis (HP:0001733)1.67854859
146Alopecia of scalp (HP:0002293)1.67477584
147Esophageal varix (HP:0002040)1.65492581

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.07379079
2MST45.73675009
3FRK5.30046169
4NME14.23477891
5MST1R4.20316026
6LMTK24.10353099
7MAP2K24.01082894
8PRKG22.72803914
9EPHA22.57820946
10GRK62.23240075
11EPHB22.21646575
12PTK62.16290196
13AKT32.14963091
14ERN12.10956131
15MAP3K22.06328496
16STK391.99647859
17OXSR11.93565140
18MAP3K101.89451581
19EPHB11.74716149
20RIPK11.65307326
21TESK11.60458220
22PAK41.51979017
23MAP3K141.42846986
24NUAK11.39331308
25MYLK1.38718536
26MAP4K11.37293994
27BMX1.31817804
28NLK1.31266712
29MAP2K11.22689374
30MAP3K71.20049871
31LATS11.19721412
32MET1.17656663
33STK101.14938766
34FER1.09188618
35IRAK31.08166541
36PRPF4B1.05771032
37MATK1.01518831
38PTK20.98075791
39MAP3K80.95792902
40DDR20.95402352
41MAPK150.89767221
42PIK3CA0.89209252
43PRKCI0.88004790
44EPHA30.87720178
45TNIK0.87043824
46TESK20.86907743
47PDK20.84147603
48LIMK10.81864444
49ROCK10.80109071
50TBK10.77787324
51TRIB30.76900433
52MAP3K30.76366002
53TAOK10.75521957
54KSR20.73914643
55TAOK30.69393700
56TRPM70.67309563
57LRRK20.65733842
58EPHA40.64935023
59ERBB20.64326046
60ROCK20.61277484
61ZAP700.61118754
62KDR0.60763834
63PDGFRA0.60753912
64PDPK10.60669015
65PRKAA20.59941030
66MAP3K10.58632195
67FGFR40.58046851
68IRAK10.56585504
69ITK0.55708550
70SMG10.55077270
71DAPK20.53981351
72GSK3A0.53910901
73CSK0.53850533
74TYK20.52606987
75MAP2K60.51225480
76IKBKE0.49141374
77SCYL20.48983731
78FGFR30.48797646
79BRAF0.48453076
80MAP3K110.47368192
81PBK0.45629006
82MAP3K120.45586743
83ABL20.45166740
84BLK0.44751812
85STK30.44625395
86JAK20.43897026
87YES10.43633535
88MAPKAPK30.41186784
89CSF1R0.40844232
90RET0.39999217
91FYN0.39796235
92PAK30.39462834
93PIM10.38862595
94CHUK0.38696642
95MAPKAPK20.38386140
96PRKCD0.37208384
97JAK10.36524173
98PAK10.34154460
99LYN0.33029050
100IRAK40.32447909
101RPS6KA20.32176087
102STK110.31337828
103BMPR20.30947252
104DMPK0.30708960
105PDK10.29632480
106SRC0.29162204
107SYK0.27806759
108BTK0.27710551
109TTK0.27695487
110PIM20.26864061
111CDC42BPA0.26510440
112CASK0.26493514
113AURKB0.26316671
114CDK190.25163736
115RPS6KA10.24626634
116GRK10.23835339
117PRKCA0.23786221
118JAK30.23260717
119PAK20.22328716
120ICK0.22311430
121CSNK1G10.22055797
122DYRK1B0.22012248
123CAMK2G0.20448195
124CSNK1A10.20031238
125STK240.19664393
126RIPK40.18625042
127CAMK2D0.18513196
128MAPK110.18109680
129MAP3K90.16680237
130WNK40.16589195
131PRKACG0.16354828
132PRKAA10.15772937
133PRKCZ0.15018358

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049755.48205375
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.70620442
3Renin-angiotensin system_Homo sapiens_hsa046144.16537203
4Mineral absorption_Homo sapiens_hsa049783.95588481
5Vitamin digestion and absorption_Homo sapiens_hsa049773.50082718
6Galactose metabolism_Homo sapiens_hsa000522.84807253
7Sulfur metabolism_Homo sapiens_hsa009202.64035265
8Caffeine metabolism_Homo sapiens_hsa002322.63122062
9Starch and sucrose metabolism_Homo sapiens_hsa005002.35313744
10Protein digestion and absorption_Homo sapiens_hsa049742.27394327
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.15006770
12Bile secretion_Homo sapiens_hsa049762.09684028
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08687277
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01809427
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.84138467
16Sphingolipid metabolism_Homo sapiens_hsa006001.81152317
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70886568
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.70215683
19Fructose and mannose metabolism_Homo sapiens_hsa000511.58405244
20Glutathione metabolism_Homo sapiens_hsa004801.57797970
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51557141
22* Histidine metabolism_Homo sapiens_hsa003401.47522544
23Folate biosynthesis_Homo sapiens_hsa007901.44678975
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.39446697
25PPAR signaling pathway_Homo sapiens_hsa033201.39442677
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28847802
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27530145
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21186703
29Asthma_Homo sapiens_hsa053101.20279089
30Glycerolipid metabolism_Homo sapiens_hsa005611.13822787
31Thyroid hormone synthesis_Homo sapiens_hsa049181.02036468
32Linoleic acid metabolism_Homo sapiens_hsa005911.00049035
33Arachidonic acid metabolism_Homo sapiens_hsa005900.99339692
34* Tryptophan metabolism_Homo sapiens_hsa003800.95814625
35Allograft rejection_Homo sapiens_hsa053300.92061700
36Autoimmune thyroid disease_Homo sapiens_hsa053200.87751709
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86712531
38Fatty acid degradation_Homo sapiens_hsa000710.84671836
39Other glycan degradation_Homo sapiens_hsa005110.83693627
40Graft-versus-host disease_Homo sapiens_hsa053320.82255895
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.80346340
42ABC transporters_Homo sapiens_hsa020100.79871730
43Staphylococcus aureus infection_Homo sapiens_hsa051500.77078669
44Arginine biosynthesis_Homo sapiens_hsa002200.75788587
45Tight junction_Homo sapiens_hsa045300.73979190
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71972835
47Pentose phosphate pathway_Homo sapiens_hsa000300.70411102
48Salmonella infection_Homo sapiens_hsa051320.67795726
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65796142
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64665845
51* Arginine and proline metabolism_Homo sapiens_hsa003300.61856961
52Type I diabetes mellitus_Homo sapiens_hsa049400.60621379
53Retinol metabolism_Homo sapiens_hsa008300.60523578
54Nitrogen metabolism_Homo sapiens_hsa009100.59807212
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59558405
56Pancreatic secretion_Homo sapiens_hsa049720.59234262
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.57562256
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54980916
59Pertussis_Homo sapiens_hsa051330.54120642
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.53538571
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53159764
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.52365562
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.51068435
64Hematopoietic cell lineage_Homo sapiens_hsa046400.48458081
65Chemical carcinogenesis_Homo sapiens_hsa052040.48216521
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47849555
67Renin secretion_Homo sapiens_hsa049240.47737539
68beta-Alanine metabolism_Homo sapiens_hsa004100.47477490
69Fatty acid metabolism_Homo sapiens_hsa012120.47255360
70Gastric acid secretion_Homo sapiens_hsa049710.45957826
71Antigen processing and presentation_Homo sapiens_hsa046120.44951497
72Tyrosine metabolism_Homo sapiens_hsa003500.43712796
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43295086
74Pyruvate metabolism_Homo sapiens_hsa006200.43175800
75Peroxisome_Homo sapiens_hsa041460.42942732
76Ether lipid metabolism_Homo sapiens_hsa005650.42537827
77Apoptosis_Homo sapiens_hsa042100.42467362
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.42074997
79African trypanosomiasis_Homo sapiens_hsa051430.40735566
80Sulfur relay system_Homo sapiens_hsa041220.40652389
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39760811
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36634259
83Insulin resistance_Homo sapiens_hsa049310.36135068
84Adherens junction_Homo sapiens_hsa045200.35123924
85Thyroid cancer_Homo sapiens_hsa052160.34718153
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.34325964
87Osteoclast differentiation_Homo sapiens_hsa043800.34128786
88Bladder cancer_Homo sapiens_hsa052190.33964369
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29872489
90Vibrio cholerae infection_Homo sapiens_hsa051100.29684339
91Hepatitis C_Homo sapiens_hsa051600.29550819
92Amoebiasis_Homo sapiens_hsa051460.28586471
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27899473
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27743221
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27716319
96Carbon metabolism_Homo sapiens_hsa012000.25759131
97Fatty acid biosynthesis_Homo sapiens_hsa000610.25260558
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.24775007
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24659025
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23021482
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22281100
102Cocaine addiction_Homo sapiens_hsa050300.21182138
103TNF signaling pathway_Homo sapiens_hsa046680.20890935
104Salivary secretion_Homo sapiens_hsa049700.18833076
105Butanoate metabolism_Homo sapiens_hsa006500.18411860
106* Metabolic pathways_Homo sapiens_hsa011000.18102717
107Type II diabetes mellitus_Homo sapiens_hsa049300.17320393
108Viral myocarditis_Homo sapiens_hsa054160.17134558
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16832454
110Toxoplasmosis_Homo sapiens_hsa051450.14853819
111Ovarian steroidogenesis_Homo sapiens_hsa049130.14844085
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14843266
113GnRH signaling pathway_Homo sapiens_hsa049120.14696701
114Insulin secretion_Homo sapiens_hsa049110.13944231
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.13896561
116Leishmaniasis_Homo sapiens_hsa051400.13798258
117ECM-receptor interaction_Homo sapiens_hsa045120.13447445
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12060329
119Legionellosis_Homo sapiens_hsa051340.11675419
120Glucagon signaling pathway_Homo sapiens_hsa049220.11534435
121Tuberculosis_Homo sapiens_hsa051520.11405053
122N-Glycan biosynthesis_Homo sapiens_hsa005100.11126718
123Phenylalanine metabolism_Homo sapiens_hsa003600.11101136
124Lysosome_Homo sapiens_hsa041420.11016568
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10814349
126Biosynthesis of amino acids_Homo sapiens_hsa012300.09823464
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06978219
128Chemokine signaling pathway_Homo sapiens_hsa040620.05979676
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.05457567

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