ANXA2R

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.81972269
2regulation of B cell receptor signaling pathway (GO:0050855)5.77275080
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.66896775
4positive regulation of gamma-delta T cell activation (GO:0046645)5.62104468
5negative T cell selection (GO:0043383)5.61546887
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19608026
7negative thymic T cell selection (GO:0045060)5.18937594
8positive thymic T cell selection (GO:0045059)5.12152193
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.07163497
10negative regulation of cell killing (GO:0031342)5.07163497
11antigen processing and presentation of endogenous antigen (GO:0019883)5.04964143
12positive T cell selection (GO:0043368)5.00772711
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.87093444
14neutrophil activation involved in immune response (GO:0002283)4.82711266
15thymic T cell selection (GO:0045061)4.60868528
16T cell selection (GO:0045058)4.51507569
17leukocyte aggregation (GO:0070486)4.35652903
18regulation of gamma-delta T cell differentiation (GO:0045586)4.32601046
19T cell migration (GO:0072678)4.32268343
20regulation of gamma-delta T cell activation (GO:0046643)4.10998903
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.10645831
22positive regulation of granulocyte differentiation (GO:0030854)3.92296574
23immunoglobulin mediated immune response (GO:0016064)3.90057495
24regulation of alpha-beta T cell proliferation (GO:0046640)3.81681713
25positive regulation of B cell differentiation (GO:0045579)3.79898258
26response to interleukin-15 (GO:0070672)3.79513419
27cellular response to interleukin-15 (GO:0071350)3.78208046
28regulation of T cell tolerance induction (GO:0002664)3.76164436
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.75774925
30mast cell activation (GO:0045576)3.75104838
31neutrophil activation (GO:0042119)3.70232907
32regulation of B cell differentiation (GO:0045577)3.66835028
33regulation of natural killer cell mediated immunity (GO:0002715)3.66217057
34regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.66217057
35NIK/NF-kappaB signaling (GO:0038061)3.65638883
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.60272571
37response to type I interferon (GO:0034340)3.55170154
38positive regulation of tolerance induction (GO:0002645)3.54772374
39cellular response to type I interferon (GO:0071357)3.54648053
40type I interferon signaling pathway (GO:0060337)3.54648053
41positive regulation of alpha-beta T cell proliferation (GO:0046641)3.54400362
42B cell receptor signaling pathway (GO:0050853)3.51282786
43T cell receptor signaling pathway (GO:0050852)3.48106177
44tolerance induction (GO:0002507)3.48031733
45regulation of regulatory T cell differentiation (GO:0045589)3.47456808
46regulation of tolerance induction (GO:0002643)3.45965305
47antigen receptor-mediated signaling pathway (GO:0050851)3.44623333
48regulation of T cell mediated cytotoxicity (GO:0001914)3.37331164
49granulocyte activation (GO:0036230)3.35507665
50myeloid cell activation involved in immune response (GO:0002275)3.32611598
51activated T cell proliferation (GO:0050798)3.32362749
52regulation of leukocyte mediated cytotoxicity (GO:0001910)3.29245767
53macrophage activation involved in immune response (GO:0002281)3.28343311
54positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26854999
55positive regulation of natural killer cell mediated immunity (GO:0002717)3.26453377
56leukocyte degranulation (GO:0043299)3.24223691
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23262120
58actin nucleation (GO:0045010)3.23189614
59response to interferon-beta (GO:0035456)3.20193406
60regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.18809744
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.16454290
62negative regulation of T cell mediated immunity (GO:0002710)3.15988917
63dendritic cell chemotaxis (GO:0002407)3.11029347
64negative regulation of leukocyte mediated immunity (GO:0002704)3.06755025
65mast cell activation involved in immune response (GO:0002279)3.06284749
66mast cell degranulation (GO:0043303)3.06284749
67B cell mediated immunity (GO:0019724)3.05797479
68T cell costimulation (GO:0031295)3.05395520
69lymphocyte costimulation (GO:0031294)3.03027740
70regulation of interleukin-2 biosynthetic process (GO:0045076)3.02582948
71regulation of cell killing (GO:0031341)2.99683343
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.98303723
73positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.97877736
74regulation of granulocyte differentiation (GO:0030852)2.97851108
75regulation of T cell receptor signaling pathway (GO:0050856)2.94250997
76positive regulation of cell killing (GO:0031343)2.93413904
77respiratory burst (GO:0045730)2.91563849
78detection of bacterium (GO:0016045)2.91555733
79interferon-gamma-mediated signaling pathway (GO:0060333)2.91508193
80cellular extravasation (GO:0045123)2.88612004
81detection of other organism (GO:0098543)2.87292948
82DNA deamination (GO:0045006)2.87057025
83positive regulation of T cell differentiation in thymus (GO:0033089)2.86026207
84antigen processing and presentation via MHC class Ib (GO:0002475)2.82128932
85response to peptidoglycan (GO:0032494)2.81105638
86regulation of isotype switching to IgG isotypes (GO:0048302)2.80046428
87negative regulation of interleukin-12 production (GO:0032695)2.80014046
88modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79277045
89positive regulation by organism of defense response of other organism involved in symbiotic interact2.79277045
90modulation by symbiont of host immune response (GO:0052553)2.79277045
91positive regulation by symbiont of host defense response (GO:0052509)2.79277045
92modulation by symbiont of host defense response (GO:0052031)2.79277045
93modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79277045
94negative regulation of T cell apoptotic process (GO:0070233)2.77229958
95regulation of alpha-beta T cell activation (GO:0046634)2.75526748
96mature B cell differentiation involved in immune response (GO:0002313)2.74402943
97positive regulation of interleukin-2 production (GO:0032743)2.74020223
98lymphocyte migration (GO:0072676)2.73389781
99defense response to protozoan (GO:0042832)2.71612663
100dendritic cell migration (GO:0036336)2.71075417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.47738846
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.96537911
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54209945
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.87661395
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.79651893
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.44653695
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28277278
8MYB_26560356_Chip-Seq_TH2_Human3.20600858
9RUNX_20019798_ChIP-Seq_JUKART_Human3.15375916
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02607527
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80783583
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72782506
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.69540440
14MYB_26560356_Chip-Seq_TH1_Human2.68436095
15MAF_26560356_Chip-Seq_TH1_Human2.62662381
16UTX_26944678_Chip-Seq_JUKART_Human2.60557866
17VDR_21846776_ChIP-Seq_THP-1_Human2.59346196
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.59255034
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47355886
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43967552
21VDR_24763502_ChIP-Seq_THP-1_Human2.37675088
22SPI1_23547873_ChIP-Seq_NB4_Human2.37641586
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25095622
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.24024835
25SCL_19346495_ChIP-Seq_HPC-7_Human2.21997307
26GATA3_27048872_Chip-Seq_THYMUS_Human2.17846400
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17487792
28MAF_26560356_Chip-Seq_TH2_Human2.15298749
29IRF8_27001747_Chip-Seq_BMDM_Mouse2.12629444
30MYC_22102868_ChIP-Seq_BL_Human2.08505654
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.99391676
32GATA3_26560356_Chip-Seq_TH2_Human1.91727055
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91476881
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.90350277
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89861365
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79748355
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76464781
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74142493
39SPI1_23127762_ChIP-Seq_K562_Human1.71658535
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66520560
41CIITA_25753668_ChIP-Seq_RAJI_Human1.65801259
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60974187
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55865827
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52183982
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.47479817
46ELF1_20517297_ChIP-Seq_JURKAT_Human1.46031172
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.45013066
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43697593
49BCL6_27268052_Chip-Seq_Bcells_Human1.40975111
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39926274
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34834221
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33750227
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31368175
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30699759
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.29564263
56BCOR_27268052_Chip-Seq_Bcells_Human1.25724527
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23798010
58VDR_24787735_ChIP-Seq_THP-1_Human1.23338696
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20703069
60VDR_23849224_ChIP-Seq_CD4+_Human1.20639453
61TCF7_22412390_ChIP-Seq_EML_Mouse1.19984751
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18672199
63KDM2B_26808549_Chip-Seq_DND41_Human1.18514944
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17610197
65PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16225814
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16188867
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15911127
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14728609
69CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11442040
70P300_27268052_Chip-Seq_Bcells_Human1.10794678
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09787353
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09622738
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08068911
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07909138
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07712106
76FOXP3_21729870_ChIP-Seq_TREG_Human1.07099352
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.04281518
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02798461
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01940197
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.01138359
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99927454
82P68_20966046_ChIP-Seq_HELA_Human0.97281690
83SPI1_20517297_ChIP-Seq_HL60_Human0.97185523
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96644097
85E2F1_20622854_ChIP-Seq_HELA_Human0.96210275
86CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96155355
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95569477
88STAT1_20625510_ChIP-Seq_HELA_Human0.94780218
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92671722
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92560397
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91296664
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90628900
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89113622
94GATA1_19941826_ChIP-Seq_K562_Human0.88959777
95CTCF_26484167_Chip-Seq_Bcells_Mouse0.88789685
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86378092
97PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85341289
98LXR_22292898_ChIP-Seq_THP-1_Human0.85287056
99PHF8_20622854_ChIP-Seq_HELA_Human0.85144953
100SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84928563

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.21873815
2MP0005671_abnormal_response_to4.14995116
3MP0003436_decreased_susceptibility_to3.78914644
4MP0003763_abnormal_thymus_physiology3.67793269
5MP0003724_increased_susceptibility_to3.58177616
6MP0001800_abnormal_humoral_immune3.29066086
7MP0005000_abnormal_immune_tolerance3.22199951
8MP0009785_altered_susceptibility_to2.88330593
9MP0005025_abnormal_response_to2.87673569
10MP0002723_abnormal_immune_serum2.85306443
11MP0002420_abnormal_adaptive_immunity2.80609443
12MP0000685_abnormal_immune_system2.78357723
13MP0001819_abnormal_immune_cell2.77060442
14MP0001790_abnormal_immune_system2.74007216
15MP0005387_immune_system_phenotype2.74007216
16MP0009333_abnormal_splenocyte_physiolog2.72202862
17MP0002452_abnormal_antigen_presenting2.70177310
18MP0002419_abnormal_innate_immunity2.67912085
19MP0002148_abnormal_hypersensitivity_rea2.64708512
20MP0002398_abnormal_bone_marrow2.37097152
21MP0000716_abnormal_immune_system2.22116398
22MP0006082_CNS_inflammation2.16658982
23MP0002166_altered_tumor_susceptibility2.11848209
24MP0002405_respiratory_system_inflammati2.11085828
25MP0000703_abnormal_thymus_morphology2.03529522
26MP0000689_abnormal_spleen_morphology1.98351341
27MP0002722_abnormal_immune_system1.94722676
28MP0005464_abnormal_platelet_physiology1.93368749
29MP0004947_skin_inflammation1.86530810
30MP0010155_abnormal_intestine_physiology1.85582381
31MP0003866_abnormal_defecation1.84897305
32MP0002396_abnormal_hematopoietic_system1.80633537
33MP0001845_abnormal_inflammatory_respons1.80309873
34MP0002429_abnormal_blood_cell1.79850530
35MP0001533_abnormal_skeleton_physiology1.76803672
36MP0001873_stomach_inflammation1.73211873
37MP0003303_peritoneal_inflammation1.69408420
38MP0005451_abnormal_body_composition1.67256193
39MP0002009_preneoplasia1.59204158
40MP0001853_heart_inflammation1.54280423
41MP0003300_gastrointestinal_ulcer1.53733556
42MP0002132_abnormal_respiratory_system1.51687995
43MP0002006_tumorigenesis1.42589366
44MP0008469_abnormal_protein_level1.38563936
45MP0005075_abnormal_melanosome_morpholog1.33399210
46MP0003806_abnormal_nucleotide_metabolis1.32619549
47MP0000465_gastrointestinal_hemorrhage1.32542219
48MP0004381_abnormal_hair_follicle1.32300559
49MP0009764_decreased_sensitivity_to1.23456360
50MP0002138_abnormal_hepatobiliary_system1.23151842
51MP0002933_joint_inflammation1.21798502
52MP0009278_abnormal_bone_marrow1.19693919
53MP0000858_altered_metastatic_potential1.11336328
54MP0002277_abnormal_respiratory_mucosa1.09838682
55MP0003828_pulmonary_edema1.06603521
56MP0003191_abnormal_cellular_cholesterol1.06331415
57MP0001986_abnormal_taste_sensitivity1.03829131
58MP0001851_eye_inflammation1.00254270
59MP0005310_abnormal_salivary_gland0.99855749
60MP0004808_abnormal_hematopoietic_stem0.96438023
61MP0005397_hematopoietic_system_phenotyp0.90874433
62MP0001545_abnormal_hematopoietic_system0.90874433
63MP0002998_abnormal_bone_remodeling0.90468604
64MP0002019_abnormal_tumor_incidence0.88210527
65MP0005166_decreased_susceptibility_to0.86805219
66MP0001764_abnormal_homeostasis0.85324481
67MP0008260_abnormal_autophagy0.83332841
68MP0009763_increased_sensitivity_to0.81733255
69MP0003448_altered_tumor_morphology0.76714056
70MP0004883_abnormal_blood_vessel0.75160119
71MP0008873_increased_physiological_sensi0.75124496
72MP0003075_altered_response_to0.73520588
73MP0005390_skeleton_phenotype0.71607148
74MP0000490_abnormal_crypts_of0.69576372
75MP0008004_abnormal_stomach_pH0.68926108
76MP0000249_abnormal_blood_vessel0.68143008
77MP0002693_abnormal_pancreas_physiology0.65070817
78MP0009765_abnormal_xenobiotic_induced0.64035409
79MP0005164_abnormal_response_to0.62075686
80MP0001919_abnormal_reproductive_system0.61801914
81MP0003172_abnormal_lysosome_physiology0.61113663
82MP0005360_urolithiasis0.59916446
83MP0000015_abnormal_ear_pigmentation0.59298750
84MP0004130_abnormal_muscle_cell0.58352818
85MP0003638_abnormal_response/metabolism_0.55972534
86MP0001663_abnormal_digestive_system0.54929590
87MP0003795_abnormal_bone_structure0.54543165
88MP0002136_abnormal_kidney_physiology0.53074686
89MP0001765_abnormal_ion_homeostasis0.52811888
90MP0006036_abnormal_mitochondrial_physio0.52568581
91MP0002928_abnormal_bile_duct0.52352354
92MP0004185_abnormal_adipocyte_glucose0.50928110
93MP0000604_amyloidosis0.50008805
94MP0005645_abnormal_hypothalamus_physiol0.49391263
95MP0003786_premature_aging0.49037413
96MP0005376_homeostasis/metabolism_phenot0.47447317
97MP0003045_fibrosis0.46420052
98MP0008872_abnormal_physiological_respon0.45283011
99MP0005058_abnormal_lysosome_morphology0.44043151
100MP0008874_decreased_physiological_sensi0.43485678

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.79980214
2T lymphocytopenia (HP:0005403)4.69480279
3Myositis (HP:0100614)4.60223623
4Abnormality of T cell number (HP:0011839)4.56524627
5Abnormal delayed hypersensitivity skin test (HP:0002963)4.32795852
6Stomatitis (HP:0010280)4.28820910
7Increased IgM level (HP:0003496)4.24945106
8Recurrent bacterial skin infections (HP:0005406)4.24942599
9Eczematoid dermatitis (HP:0000976)4.24087608
10Recurrent abscess formation (HP:0002722)4.23915301
11Abnormality of T cells (HP:0002843)4.14403865
12Severe combined immunodeficiency (HP:0004430)4.02959008
13Panhypogammaglobulinemia (HP:0003139)4.02710077
14Recurrent fungal infections (HP:0002841)3.96177663
15Meningitis (HP:0001287)3.96127783
16Encephalitis (HP:0002383)3.87646836
17Gastrointestinal infarctions (HP:0005244)3.86281168
18Autoimmune hemolytic anemia (HP:0001890)3.81756681
19Abnormality of B cell number (HP:0010975)3.81040340
20Abnormality of macrophages (HP:0004311)3.79838677
21IgG deficiency (HP:0004315)3.70353480
22Chronic obstructive pulmonary disease (HP:0006510)3.64711587
23Obstructive lung disease (HP:0006536)3.64711587
24Mediastinal lymphadenopathy (HP:0100721)3.59975853
25Granulocytopenia (HP:0001913)3.59014657
26Abnormality of T cell physiology (HP:0011840)3.55651626
27Recurrent viral infections (HP:0004429)3.54982261
28Orchitis (HP:0100796)3.52074164
29Agammaglobulinemia (HP:0004432)3.44961229
30Optic neuritis (HP:0100653)3.44381226
31Retrobulbar optic neuritis (HP:0100654)3.44381226
32Chronic mucocutaneous candidiasis (HP:0002728)3.43405292
33Recurrent cutaneous fungal infections (HP:0011370)3.43405292
34Eosinophilia (HP:0001880)3.38144491
35B lymphocytopenia (HP:0010976)3.35917137
36Vasculitis (HP:0002633)3.25548310
37Pustule (HP:0200039)3.25103474
38Abnormality of the prostate (HP:0008775)3.23348703
39Combined immunodeficiency (HP:0005387)3.23310154
40Abnormality of eosinophils (HP:0001879)3.22786711
41Pulmonary infiltrates (HP:0002113)3.22074985
42Recurrent skin infections (HP:0001581)3.17808668
43Leukocytosis (HP:0001974)3.15153489
44Autoimmune thrombocytopenia (HP:0001973)3.12760178
45Stomach cancer (HP:0012126)3.09725002
46Chest pain (HP:0100749)3.01778893
47Prostate neoplasm (HP:0100787)2.92238427
48Inflammation of the large intestine (HP:0002037)2.82250567
49Spontaneous hematomas (HP:0007420)2.78438093
50Keratoconjunctivitis sicca (HP:0001097)2.74432740
51Gastrointestinal inflammation (HP:0004386)2.74381411
52Hemoptysis (HP:0002105)2.73100051
53Hypergammaglobulinemia (HP:0010702)2.69925519
54IgM deficiency (HP:0002850)2.68944522
55Recurrent bronchitis (HP:0002837)2.68527796
56Lymphopenia (HP:0001888)2.66168073
57Recurrent gram-negative bacterial infections (HP:0005420)2.65743528
58Prolonged bleeding time (HP:0003010)2.59656986
59Keratoconjunctivitis (HP:0001096)2.55015373
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.54198202
61Chronic diarrhea (HP:0002028)2.53902785
62Acute hepatic failure (HP:0006554)2.50221022
63Colitis (HP:0002583)2.48872557
64Thyroiditis (HP:0100646)2.44529759
65Increased IgE level (HP:0003212)2.43491786
66Epistaxis (HP:0000421)2.41525217
67Arterial thrombosis (HP:0004420)2.34576127
68Pulmonary embolism (HP:0002204)2.28452613
69Urticaria (HP:0001025)2.24488947
70Verrucae (HP:0200043)2.22502628
71Papilloma (HP:0012740)2.22502628
72Hypertensive crisis (HP:0100735)2.21951952
73Lymphoma (HP:0002665)2.21640107
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19061225
75Thrombocytosis (HP:0001894)2.19020068
76Gangrene (HP:0100758)2.18762851
77Abnormality of the pleura (HP:0002103)2.18323031
78Petechiae (HP:0000967)2.16958983
79Chronic otitis media (HP:0000389)2.10100724
80Hypochromic anemia (HP:0001931)2.08938674
81Hypoproteinemia (HP:0003075)2.07531910
82Aplastic anemia (HP:0001915)2.06917534
83Cellulitis (HP:0100658)2.06183887
84Anorexia (HP:0002039)2.03682113
85Alveolar cell carcinoma (HP:0006519)2.03018419
86Aplasia/Hypoplasia of the thymus (HP:0010515)2.01157711
87Abnormality of the columella (HP:0009929)1.99726310
88Joint swelling (HP:0001386)1.98511248
89Abnormality of male internal genitalia (HP:0000022)1.97515444
90Episodic fever (HP:0001954)1.93696622
91Keratitis (HP:0000491)1.90773366
92Recurrent sinusitis (HP:0011108)1.90669328
93Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90275433
94Sepsis (HP:0100806)1.89765054
95Skin rash (HP:0000988)1.88616753
96Pulmonary fibrosis (HP:0002206)1.85380467
97Increased serum ferritin (HP:0003281)1.84750194
98Glomerulopathy (HP:0100820)1.84484432
99Hypoplasia of the thymus (HP:0000778)1.82637063
100Microcytic anemia (HP:0001935)1.78152226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.57701070
2TAOK34.53680394
3TXK3.30395040
4RIPK42.96354427
5KDR2.75560779
6TESK22.67495100
7GRK62.56807348
8FES2.37638561
9IKBKE2.30945547
10ZAP702.28750807
11ITK2.26829197
12SYK2.18490006
13BTK2.06913899
14TEC1.87853381
15TYK21.85407536
16TBK11.80947538
17CSK1.71521712
18ERN11.68131846
19JAK31.66869173
20TLK11.65834457
21BLK1.65216917
22CSF1R1.62859845
23IRAK41.59953669
24LCK1.59885921
25TNK21.53561525
26SCYL21.45747035
27MAP3K111.45610446
28KIT1.42027893
29IKBKB1.41974124
30BMPR21.41694523
31MAP3K141.41438256
32LYN1.33945945
33HCK1.31702286
34MAP3K101.23990444
35PRPF4B1.19822692
36VRK21.17983291
37CAMKK21.17947514
38MAP2K31.16494466
39HIPK21.14485457
40MARK31.13074155
41MAP2K21.06462070
42PRKCQ1.05441950
43GRK71.04060654
44STK101.00858404
45PIM10.96565533
46BCKDK0.95886890
47CAMKK10.95822370
48JAK10.95481666
49PASK0.90890829
50MAPKAPK30.89339034
51TRPM70.88742550
52GRK50.87170141
53PIK3CG0.86659255
54SMG10.81684462
55MAPK110.81472052
56ADRBK20.79015688
57PDK10.78611641
58JAK20.75483857
59CDK40.75064850
60STK160.71711415
61MAP3K130.71636485
62ZAK0.64632593
63MAP3K120.60773478
64LRRK20.59357632
65MAPK120.58868839
66MAP3K30.54249860
67MAP3K10.53940141
68DAPK10.52885145
69TAF10.48257137
70MATK0.47961057
71NUAK10.46598158
72MAPK70.45178859
73RPS6KB20.45072538
74MELK0.44315530
75RPS6KL10.42784047
76RPS6KC10.42784047
77RPS6KA60.42223683
78MAPK150.40361153
79MAP2K60.40025910
80ADRBK10.39580529
81TGFBR20.38198374
82PTK2B0.38134696
83MAPKAPK20.37662935
84VRK10.37385564
85CLK10.37223493
86MAP3K50.35664204
87FYN0.34579184
88MAP3K70.34316512
89NLK0.34025603
90PRKD20.33763535
91ABL10.31470774
92GRK10.30575704
93IGF1R0.30364119
94TIE10.27396935
95FLT30.27048575
96PDPK10.26667778
97MAPK40.25174185
98STK380.25091551
99MAPK30.24940792
100CDK120.24727616

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.54085177
2Allograft rejection_Homo sapiens_hsa053303.61148229
3Graft-versus-host disease_Homo sapiens_hsa053323.48578884
4Autoimmune thyroid disease_Homo sapiens_hsa053203.47972902
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.72206354
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.71716508
7T cell receptor signaling pathway_Homo sapiens_hsa046602.56418861
8Antigen processing and presentation_Homo sapiens_hsa046122.50601309
9Asthma_Homo sapiens_hsa053102.49622379
10Type I diabetes mellitus_Homo sapiens_hsa049402.46942050
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37820251
12Hematopoietic cell lineage_Homo sapiens_hsa046402.31896467
13Leishmaniasis_Homo sapiens_hsa051402.25986136
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22177273
15Viral myocarditis_Homo sapiens_hsa054162.00696540
16Osteoclast differentiation_Homo sapiens_hsa043801.94779547
17Staphylococcus aureus infection_Homo sapiens_hsa051501.93571730
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92641095
19Measles_Homo sapiens_hsa051621.92119938
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.91010531
21B cell receptor signaling pathway_Homo sapiens_hsa046621.79182368
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63082221
23Herpes simplex infection_Homo sapiens_hsa051681.57100117
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56000205
25Malaria_Homo sapiens_hsa051441.40451390
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40264707
27Tuberculosis_Homo sapiens_hsa051521.39110711
28Influenza A_Homo sapiens_hsa051641.34117200
29Rheumatoid arthritis_Homo sapiens_hsa053231.32076226
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30762593
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28723927
32Acute myeloid leukemia_Homo sapiens_hsa052211.23723561
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.18981771
34TNF signaling pathway_Homo sapiens_hsa046681.14642411
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14093191
36Ribosome_Homo sapiens_hsa030101.13720855
37Toxoplasmosis_Homo sapiens_hsa051451.12175200
38Chemokine signaling pathway_Homo sapiens_hsa040621.06591694
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05507832
40Other glycan degradation_Homo sapiens_hsa005111.03780198
41Systemic lupus erythematosus_Homo sapiens_hsa053221.01392541
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96773874
43Shigellosis_Homo sapiens_hsa051310.96136676
44Linoleic acid metabolism_Homo sapiens_hsa005910.95631570
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91955826
46Legionellosis_Homo sapiens_hsa051340.91320179
47Epstein-Barr virus infection_Homo sapiens_hsa051690.88939563
48Hepatitis B_Homo sapiens_hsa051610.85880466
49Apoptosis_Homo sapiens_hsa042100.85677768
50Platelet activation_Homo sapiens_hsa046110.84385668
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81225450
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.74565621
53Pertussis_Homo sapiens_hsa051330.72496686
54Hepatitis C_Homo sapiens_hsa051600.71655353
55Non-small cell lung cancer_Homo sapiens_hsa052230.70590859
56Viral carcinogenesis_Homo sapiens_hsa052030.69014207
57HTLV-I infection_Homo sapiens_hsa051660.65712514
58Arachidonic acid metabolism_Homo sapiens_hsa005900.64378204
59African trypanosomiasis_Homo sapiens_hsa051430.62890886
60Proteasome_Homo sapiens_hsa030500.61818807
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55242393
62Phagosome_Homo sapiens_hsa041450.51317625
63VEGF signaling pathway_Homo sapiens_hsa043700.48771551
64RNA polymerase_Homo sapiens_hsa030200.48356695
65Nitrogen metabolism_Homo sapiens_hsa009100.46501270
66Endocytosis_Homo sapiens_hsa041440.46380383
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44744963
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44581410
69Salmonella infection_Homo sapiens_hsa051320.43946943
70Ether lipid metabolism_Homo sapiens_hsa005650.42973042
71Regulation of autophagy_Homo sapiens_hsa041400.39732913
72Phototransduction_Homo sapiens_hsa047440.37855946
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36783044
74MAPK signaling pathway_Homo sapiens_hsa040100.35568694
75Pancreatic cancer_Homo sapiens_hsa052120.34767015
76Chronic myeloid leukemia_Homo sapiens_hsa052200.33968621
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33916590
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33525374
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.31696245
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.30261093
81Pyrimidine metabolism_Homo sapiens_hsa002400.28369401
82Homologous recombination_Homo sapiens_hsa034400.26445038
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.23299487
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22911753
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.22869528
86Insulin resistance_Homo sapiens_hsa049310.20700080
87Ras signaling pathway_Homo sapiens_hsa040140.20338874
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19913212
89FoxO signaling pathway_Homo sapiens_hsa040680.19376622
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18960838
91Prolactin signaling pathway_Homo sapiens_hsa049170.17785614
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.16496701
93Lysosome_Homo sapiens_hsa041420.16180200
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14963730
95Choline metabolism in cancer_Homo sapiens_hsa052310.14711658
96Purine metabolism_Homo sapiens_hsa002300.14488173
97Parkinsons disease_Homo sapiens_hsa050120.14226072
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12777739
99Sulfur relay system_Homo sapiens_hsa041220.12273709
100Base excision repair_Homo sapiens_hsa034100.08959205

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