ANXA11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35257655
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16443821
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16443821
4antigen processing and presentation of endogenous antigen (GO:0019883)3.74599610
5positive regulation by symbiont of host defense response (GO:0052509)3.69975610
6modulation by symbiont of host defense response (GO:0052031)3.69975610
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69975610
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69975610
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.69975610
10modulation by symbiont of host immune response (GO:0052553)3.69975610
11negative regulation of erythrocyte differentiation (GO:0045647)3.67262710
12response to peptidoglycan (GO:0032494)3.62910063
13detection of other organism (GO:0098543)3.61210110
14detection of bacterium (GO:0016045)3.57555709
15neutrophil activation involved in immune response (GO:0002283)3.53271124
16barbed-end actin filament capping (GO:0051016)3.36051426
17regulation of gamma-delta T cell differentiation (GO:0045586)3.24143949
18regulation of cholesterol homeostasis (GO:2000188)3.21134257
19leukocyte aggregation (GO:0070486)3.21066027
20macrophage activation involved in immune response (GO:0002281)3.20807299
21positive regulation of histone deacetylation (GO:0031065)3.12572238
22positive regulation of gamma-delta T cell activation (GO:0046645)3.11550069
23low-density lipoprotein particle clearance (GO:0034383)3.11248109
24pinocytosis (GO:0006907)3.01690457
25mannose metabolic process (GO:0006013)3.01251633
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99183981
27detection of external biotic stimulus (GO:0098581)2.99061010
28pentose-phosphate shunt (GO:0006098)2.99019198
29germinal center formation (GO:0002467)2.97354495
30regulation of gamma-delta T cell activation (GO:0046643)2.96506848
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.92024330
32positive regulation of Cdc42 GTPase activity (GO:0043089)2.90806867
33regulation of leukocyte degranulation (GO:0043300)2.87181401
34regulation of necroptotic process (GO:0060544)2.83718274
35regulation of mast cell degranulation (GO:0043304)2.83520961
36bundle of His cell to Purkinje myocyte communication (GO:0086069)2.82400377
37regulation of cholesterol storage (GO:0010885)2.81896155
38NIK/NF-kappaB signaling (GO:0038061)2.80043018
39response to type I interferon (GO:0034340)2.79174692
40type I interferon signaling pathway (GO:0060337)2.78092842
41cellular response to type I interferon (GO:0071357)2.78092842
42valine metabolic process (GO:0006573)2.77916320
43positive regulation of lamellipodium assembly (GO:0010592)2.74949938
44lysine metabolic process (GO:0006553)2.74497416
45lysine catabolic process (GO:0006554)2.74497416
46lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73951579
47positive regulation of p38MAPK cascade (GO:1900745)2.72334364
48regulation of myeloid leukocyte mediated immunity (GO:0002886)2.71164333
49maternal placenta development (GO:0001893)2.70682182
50negative regulation of lymphocyte mediated immunity (GO:0002707)2.68012254
51negative regulation of leukocyte mediated immunity (GO:0002704)2.66586734
52response to muramyl dipeptide (GO:0032495)2.66252834
53endothelial tube morphogenesis (GO:0061154)2.65266850
54morphogenesis of an endothelium (GO:0003159)2.65266850
55response to host (GO:0075136)2.64321312
56response to host defenses (GO:0052200)2.64321312
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64321312
58regulation of necrotic cell death (GO:0010939)2.64261114
59regulation of T-helper 2 cell differentiation (GO:0045628)2.63065375
60defense response to fungus (GO:0050832)2.62153231
61response to laminar fluid shear stress (GO:0034616)2.61742777
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.61395068
63B cell receptor signaling pathway (GO:0050853)2.60916338
64embryonic process involved in female pregnancy (GO:0060136)2.60816805
65positive thymic T cell selection (GO:0045059)2.60139950
66regulation of tolerance induction (GO:0002643)2.59921586
67regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59797257
68positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59711195
69negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59083759
70NADPH regeneration (GO:0006740)2.58851092
71apoptotic process involved in morphogenesis (GO:0060561)2.58802957
72trophectodermal cell differentiation (GO:0001829)2.58572382
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58397937
74positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.57969538
752-oxoglutarate metabolic process (GO:0006103)2.57143515
76tolerance induction (GO:0002507)2.54843542
77carnitine shuttle (GO:0006853)2.54335059
78detection of molecule of bacterial origin (GO:0032490)2.53907881
79stress fiber assembly (GO:0043149)2.52946245
80interferon-gamma-mediated signaling pathway (GO:0060333)2.52306397
81response to host immune response (GO:0052572)2.51115754
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51115754
83fatty acid transmembrane transport (GO:1902001)2.50782123
84regulation of T cell tolerance induction (GO:0002664)2.49850040
85respiratory burst (GO:0045730)2.49378722
86regulation of mast cell activation involved in immune response (GO:0033006)2.49314406
87negative regulation of interleukin-12 production (GO:0032695)2.48690027
88detection of biotic stimulus (GO:0009595)2.48393658
89regulation of podosome assembly (GO:0071801)2.48235394
90neutrophil activation (GO:0042119)2.47397975
91granulocyte activation (GO:0036230)2.46661044
92JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.45278192
93regulation of integrin activation (GO:0033623)2.44472715
94cell-substrate junction assembly (GO:0007044)2.44267853
95sulfur amino acid catabolic process (GO:0000098)2.43923176
96myeloid dendritic cell differentiation (GO:0043011)2.43803283
97regulation of extracellular matrix disassembly (GO:0010715)2.43084633
98positive regulation of lamellipodium organization (GO:1902745)2.42187431
99apoptotic cell clearance (GO:0043277)2.41834803
100regulation of superoxide anion generation (GO:0032928)2.41743830
101antigen processing and presentation via MHC class Ib (GO:0002475)2.41555876
102establishment of endothelial barrier (GO:0061028)2.41532001
103protein localization to endosome (GO:0036010)2.41531808
104regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.41335581
105positive regulation of protein deacetylation (GO:0090312)2.40544371
106epithelial cell-cell adhesion (GO:0090136)2.39115175
107skeletal muscle adaptation (GO:0043501)2.38967524
108cellular hyperosmotic response (GO:0071474)2.37717212
109muscle filament sliding (GO:0030049)2.36989894
110actin-myosin filament sliding (GO:0033275)2.36989894
111growth hormone receptor signaling pathway (GO:0060396)2.36158727
112embryonic placenta development (GO:0001892)2.34993074
113positive regulation of extracellular matrix organization (GO:1903055)2.34937147
114regulation of p38MAPK cascade (GO:1900744)2.34442819
115leukocyte cell-cell adhesion (GO:0007159)2.34364736
116negative thymic T cell selection (GO:0045060)2.34284981
117positive regulation of receptor recycling (GO:0001921)2.33533341
118cellular response to thyroid hormone stimulus (GO:0097067)2.33532639
119tricarboxylic acid metabolic process (GO:0072350)2.32640932
120glycosphingolipid catabolic process (GO:0046479)2.32599416
121positive regulation of lipid storage (GO:0010884)2.31668612
122negative regulation of necroptotic process (GO:0060546)2.31567573
123negative regulation of phagocytosis (GO:0050765)2.31523085
124myeloid cell activation involved in immune response (GO:0002275)2.30582542
125cellular extravasation (GO:0045123)2.30158280
126positive regulation of B cell differentiation (GO:0045579)2.29756077
127negative regulation of cell size (GO:0045792)2.29340372
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.28652500
129regulation of type I interferon-mediated signaling pathway (GO:0060338)2.27775353
130negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.27151948
131positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26954047
132negative regulation of interleukin-6 production (GO:0032715)2.26877708
1334-hydroxyproline metabolic process (GO:0019471)2.26551706
134regulation of interleukin-12 biosynthetic process (GO:0045075)2.26300403
135positive regulation of tolerance induction (GO:0002645)2.26078047
136regulation of regulated secretory pathway (GO:1903305)2.25817521
137plasma membrane repair (GO:0001778)2.25776620
138positive regulation of cellular amide metabolic process (GO:0034250)2.25297494
139modulation by symbiont of host cellular process (GO:0044068)2.24694262
140regulation of antigen processing and presentation (GO:0002577)2.24418962
141T cell selection (GO:0045058)2.24243262
142immunoglobulin mediated immune response (GO:0016064)2.23764237
143sarcomere organization (GO:0045214)2.22158810
144cellular response to osmotic stress (GO:0071470)2.21435568
145negative regulation of heart growth (GO:0061117)2.21349954
146negative regulation of cardiac muscle tissue growth (GO:0055022)2.21349954
147phospholipid homeostasis (GO:0055091)2.20654563
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.20091442
149hepatocyte apoptotic process (GO:0097284)2.19609631
150striated muscle atrophy (GO:0014891)2.18419715
151response to fungus (GO:0009620)2.16782767
152fatty acid beta-oxidation (GO:0006635)2.14629146
153oxaloacetate metabolic process (GO:0006107)2.14406768
154hormone catabolic process (GO:0042447)2.13461279
155glucose catabolic process (GO:0006007)2.13083576
156hypotonic response (GO:0006971)2.11955809
157regulation of translational fidelity (GO:0006450)2.11842446
158regulation of B cell receptor signaling pathway (GO:0050855)2.11827397
159hemidesmosome assembly (GO:0031581)2.11445089
160negative regulation of stress fiber assembly (GO:0051497)2.11064299
161nucleotide salvage (GO:0043173)2.09399359
162carnitine transport (GO:0015879)2.09076359
163amino-acid betaine transport (GO:0015838)2.09076359
164thymic T cell selection (GO:0045061)2.08556026
165negative regulation of innate immune response (GO:0045824)2.08437508
166positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.08360247
167cell-substrate adherens junction assembly (GO:0007045)2.07609867
168focal adhesion assembly (GO:0048041)2.07609867
169ethanol oxidation (GO:0006069)2.04972603
170regulation of fatty acid beta-oxidation (GO:0031998)2.04666468
171regulation of response to interferon-gamma (GO:0060330)2.03986085
172negative regulation of toll-like receptor signaling pathway (GO:0034122)2.03299730
173purine nucleotide salvage (GO:0032261)2.02925104
174negative regulation of cell killing (GO:0031342)2.02728153
175negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.02728153
176regulation of interferon-beta biosynthetic process (GO:0045357)2.02253944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.85089883
2EGR1_19374776_ChIP-ChIP_THP-1_Human2.80503051
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79586142
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.73272299
5MYC_22102868_ChIP-Seq_BL_Human2.60609818
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.36637298
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.35257980
8VDR_21846776_ChIP-Seq_THP-1_Human2.26616811
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.19359287
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12673440
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.07288561
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03358002
13MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99069590
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.97362038
15TCF7_22412390_ChIP-Seq_EML_Mouse1.93870037
16* MAF_26560356_Chip-Seq_TH1_Human1.88086957
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83891522
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82273898
19BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79510236
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.78422606
21LXR_22158963_ChIP-Seq_LIVER_Mouse1.74999322
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73920392
23LXR_22292898_ChIP-Seq_THP-1_Human1.71184797
24KDM2B_26808549_Chip-Seq_DND41_Human1.68103971
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67682111
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66895418
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66812712
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66486465
29UTX_26944678_Chip-Seq_JUKART_Human1.65650018
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.65335245
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64623645
32CLOCK_20551151_ChIP-Seq_293T_Human1.63825753
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61961918
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.57779458
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57042168
36E2F7_22180533_ChIP-Seq_HELA_Human1.56954817
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55215700
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54651017
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54556115
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54249737
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54157642
42ZNF263_19887448_ChIP-Seq_K562_Human1.53635439
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53308258
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52124091
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51769443
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49792481
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.44590556
48VDR_24763502_ChIP-Seq_THP-1_Human1.43866059
49* GATA1_19941827_ChIP-Seq_MEL_Mouse1.41208470
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.39210906
51* ATF3_27146783_Chip-Seq_COLON_Human1.37965369
52SCL_19346495_ChIP-Seq_HPC-7_Human1.36544683
53* MYB_26560356_Chip-Seq_TH2_Human1.35200771
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34606529
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.34320623
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33889323
57* MYB_26560356_Chip-Seq_TH1_Human1.32354441
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31645048
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31637292
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31031735
61SPI1_23127762_ChIP-Seq_K562_Human1.31020575
62* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29886727
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29666151
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28377668
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28143847
66* GATA2_21666600_ChIP-Seq_HMVEC_Human1.27389368
67* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27281097
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25501125
69NCOR1_26117541_ChIP-Seq_K562_Human1.25003657
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.24700652
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23271478
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.22008543
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21346524
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20458604
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18206234
76* KDM2B_26808549_Chip-Seq_K562_Human1.17806416
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16650965
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16275126
79* SA1_27219007_Chip-Seq_ERYTHROID_Human1.16213809
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16203495
81* MAF_26560356_Chip-Seq_TH2_Human1.15882517
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15459648
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.15440434
84* GATA6_25053715_ChIP-Seq_YYC3_Human1.14527046
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14395565
86SPI1_23547873_ChIP-Seq_NB4_Human1.14173751
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13859200
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13383973
89* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12639899
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12171963
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11552240
92* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10939777
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10916029
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09994016
95* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09649350
96* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09496368
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09472054
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.08964611
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08935944
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08935944
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08935944
102GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08277803
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08069322
104GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06966587
105GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05898805
106* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05756409
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05437133
108RUNX_20019798_ChIP-Seq_JUKART_Human1.04549201
109TBX20_22080862_ChIP-Seq_HEART_Mouse1.03810897
110TBX20_22328084_ChIP-Seq_HEART_Mouse1.03810897
111* SMC4_20622854_ChIP-Seq_HELA_Human1.02700083
112ELF1_20517297_ChIP-Seq_JURKAT_Human1.02539913
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.01732184
114PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01489056
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01243495
116IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00538937
117BCOR_27268052_Chip-Seq_Bcells_Human1.00525439
118GATA1_19941826_ChIP-Seq_K562_Human1.00420855
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.99565746
120ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99173408
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98863512
122NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96787927
123* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96736476
124* P68_20966046_ChIP-Seq_HELA_Human0.96080705
125BCL6_27268052_Chip-Seq_Bcells_Human0.95846855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog2.76121711
2MP0005360_urolithiasis2.52453767
3MP0005451_abnormal_body_composition2.45495063
4MP0003303_peritoneal_inflammation2.31406868
5MP0003300_gastrointestinal_ulcer2.26585123
6MP0009278_abnormal_bone_marrow2.24112243
7MP0010352_gastrointestinal_tract_polyps2.21371321
8MP0003436_decreased_susceptibility_to2.17593526
9MP0003191_abnormal_cellular_cholesterol2.14702999
10MP0009840_abnormal_foam_cell2.04487628
11MP0003566_abnormal_cell_adhesion2.02140973
12MP0002148_abnormal_hypersensitivity_rea1.85789339
13MP0003172_abnormal_lysosome_physiology1.79988368
14MP0002837_dystrophic_cardiac_calcinosis1.74783896
15MP0000685_abnormal_immune_system1.71083539
16MP0003806_abnormal_nucleotide_metabolis1.69481028
17MP0008260_abnormal_autophagy1.67891440
18MP0010234_abnormal_vibrissa_follicle1.66923748
19MP0002139_abnormal_hepatobiliary_system1.65222599
20MP0008438_abnormal_cutaneous_collagen1.62567166
21MP0004947_skin_inflammation1.61590771
22MP0010155_abnormal_intestine_physiology1.61081967
23MP0005076_abnormal_cell_differentiation1.54885652
24MP0002998_abnormal_bone_remodeling1.50251096
25MP0001958_emphysema1.47914807
26MP0009785_altered_susceptibility_to1.47304066
27MP0000343_altered_response_to1.46850681
28MP0005023_abnormal_wound_healing1.46594890
29MP0001835_abnormal_antigen_presentation1.44787324
30MP0004510_myositis1.44523585
31MP0003279_aneurysm1.44123204
32MP0001873_stomach_inflammation1.43343772
33MP0003091_abnormal_cell_migration1.42237573
34MP0001790_abnormal_immune_system1.40791967
35MP0005387_immune_system_phenotype1.40791967
36MP0005464_abnormal_platelet_physiology1.38945634
37MP0005025_abnormal_response_to1.38214035
38MP0005085_abnormal_gallbladder_physiolo1.37897910
39MP0001800_abnormal_humoral_immune1.37504082
40MP0004185_abnormal_adipocyte_glucose1.36637039
41MP0004264_abnormal_extraembryonic_tissu1.36120182
42MP0005397_hematopoietic_system_phenotyp1.35808032
43MP0001545_abnormal_hematopoietic_system1.35808032
44MP0005058_abnormal_lysosome_morphology1.35056255
45MP0002138_abnormal_hepatobiliary_system1.34964225
46MP0002405_respiratory_system_inflammati1.31557316
47MP0005365_abnormal_bile_salt1.31052184
48MP0002419_abnormal_innate_immunity1.26056321
49MP0003453_abnormal_keratinocyte_physiol1.25075121
50MP0005166_decreased_susceptibility_to1.24343509
51MP0003724_increased_susceptibility_to1.23703463
52MP0003828_pulmonary_edema1.23675897
53MP0004130_abnormal_muscle_cell1.22859968
54MP0002132_abnormal_respiratory_system1.22729732
55MP0005167_abnormal_blood-brain_barrier1.22600114
56MP0002452_abnormal_antigen_presenting1.22291340
57MP0001853_heart_inflammation1.21647985
58MP0003183_abnormal_peptide_metabolism1.20841492
59MP0000465_gastrointestinal_hemorrhage1.20778063
60MP0005000_abnormal_immune_tolerance1.18741860
61MP0000609_abnormal_liver_physiology1.18502416
62MP0001845_abnormal_inflammatory_respons1.18386014
63MP0008875_abnormal_xenobiotic_pharmacok1.18277425
64MP0004087_abnormal_muscle_fiber1.16040970
65MP0006082_CNS_inflammation1.15002751
66MP0000750_abnormal_muscle_regeneration1.13780877
67MP0008961_abnormal_basal_metabolism1.13755146
68MP0005319_abnormal_enzyme/_coenzyme1.13039143
69MP0000749_muscle_degeneration1.12765299
70MP0010329_abnormal_lipoprotein_level1.12603268
71MP0002420_abnormal_adaptive_immunity1.12497223
72MP0001819_abnormal_immune_cell1.12495184
73MP0000604_amyloidosis1.12262974
74MP0002723_abnormal_immune_serum1.11354567
75MP0001533_abnormal_skeleton_physiology1.10664962
76MP0000490_abnormal_crypts_of1.10318595
77MP0003252_abnormal_bile_duct1.10249812
78MP0005666_abnormal_adipose_tissue1.09916700
79MP0002166_altered_tumor_susceptibility1.08792445
80MP0002877_abnormal_melanocyte_morpholog1.08611287
81MP0000858_altered_metastatic_potential1.07735207
82MP0005164_abnormal_response_to1.07502513
83MP0004084_abnormal_cardiac_muscle1.07459069
84MP0000751_myopathy1.06923955
85MP0001851_eye_inflammation1.06508833
86MP0005165_increased_susceptibility_to1.06022447
87MP0009643_abnormal_urine_homeostasis1.05803276
88MP0010630_abnormal_cardiac_muscle1.03532606
89MP0002398_abnormal_bone_marrow1.03412247
90MP0003646_muscle_fatigue1.03110853
91MP0001849_ear_inflammation1.02932540
92MP0003448_altered_tumor_morphology1.01907125
93MP0002269_muscular_atrophy1.01792398
94MP0001666_abnormal_nutrient_absorption1.01762099
95MP0008004_abnormal_stomach_pH1.01040484
96MP0005310_abnormal_salivary_gland1.00963119
97MP0003866_abnormal_defecation1.00540974
98MP0003763_abnormal_thymus_physiology1.00397767
99MP0000689_abnormal_spleen_morphology0.98315873
100MP0003045_fibrosis0.97998203
101MP0008469_abnormal_protein_level0.97824774
102MP0002722_abnormal_immune_system0.97735948
103MP0005390_skeleton_phenotype0.97283257
104MP0006054_spinal_hemorrhage0.97188788
105MP0009333_abnormal_splenocyte_physiolog0.96912583
106MP0004808_abnormal_hematopoietic_stem0.96538971
107MP0000716_abnormal_immune_system0.96067210
108MP0005671_abnormal_response_to0.95466228
109MP0004883_abnormal_blood_vessel0.95262068
110MP0002396_abnormal_hematopoietic_system0.94980875
111MP0000733_abnormal_muscle_development0.92946138
112MP0003075_altered_response_to0.91962291
113MP0000747_muscle_weakness0.91248531
114MP0000249_abnormal_blood_vessel0.91070090
115MP0002796_impaired_skin_barrier0.90804959
116MP0005375_adipose_tissue_phenotype0.90552714
117MP0005330_cardiomyopathy0.89763693
118MP0010307_abnormal_tumor_latency0.88770510
119MP0002429_abnormal_blood_cell0.88329999
120MP0005083_abnormal_biliary_tract0.88212113
121MP0002933_joint_inflammation0.87814786
122MP0002106_abnormal_muscle_physiology0.85369289
123MP0002136_abnormal_kidney_physiology0.85156621
124MP0003795_abnormal_bone_structure0.83661213
125MP0004858_abnormal_nervous_system0.83173251
126MP0009764_decreased_sensitivity_to0.82145759
127MP0003329_amyloid_beta_deposits0.81957237
128MP0001663_abnormal_digestive_system0.79849069
129MP0000703_abnormal_thymus_morphology0.78895463
130MP0005670_abnormal_white_adipose0.77516606

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.39679851
2Ulnar deviation of the wrist (HP:0003049)3.36895753
3Increased connective tissue (HP:0009025)3.35885966
4Abnormality of glycolipid metabolism (HP:0010969)3.34699952
5Abnormality of liposaccharide metabolism (HP:0010968)3.34699952
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.34699952
7Eczematoid dermatitis (HP:0000976)3.31286442
8Exercise-induced muscle cramps (HP:0003710)3.05006571
9Hyporeflexia of lower limbs (HP:0002600)2.86422602
10Asymmetric septal hypertrophy (HP:0001670)2.79053337
11Type 1 muscle fiber predominance (HP:0003803)2.78671256
12Muscle fiber inclusion bodies (HP:0100299)2.77719492
13Exercise-induced myalgia (HP:0003738)2.77453549
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.72524536
15Interstitial pulmonary disease (HP:0006530)2.69530202
16Pustule (HP:0200039)2.67108920
17Ventricular tachycardia (HP:0004756)2.65399868
18Myoglobinuria (HP:0002913)2.64251105
19Muscle fiber splitting (HP:0003555)2.63296074
20Abnormality of the nasal mucosa (HP:0000433)2.56174481
21Obstructive lung disease (HP:0006536)2.55974084
22Chronic obstructive pulmonary disease (HP:0006510)2.55974084
23Autoimmune thrombocytopenia (HP:0001973)2.52330083
24Increased cerebral lipofuscin (HP:0011813)2.52172082
25Systemic lupus erythematosus (HP:0002725)2.51026648
26Mediastinal lymphadenopathy (HP:0100721)2.49799141
27Vertebral compression fractures (HP:0002953)2.48725899
28Recurrent abscess formation (HP:0002722)2.48105611
29Distal arthrogryposis (HP:0005684)2.45785012
30Myopathic facies (HP:0002058)2.44163182
31Recurrent gram-negative bacterial infections (HP:0005420)2.42526900
32Difficulty climbing stairs (HP:0003551)2.39776168
33Difficulty running (HP:0009046)2.39742278
34Polycythemia (HP:0001901)2.36721661
35Distal lower limb amyotrophy (HP:0008944)2.36562814
36Protrusio acetabuli (HP:0003179)2.36433832
37Spontaneous hematomas (HP:0007420)2.34667586
38Rhabdomyolysis (HP:0003201)2.33923910
39Nemaline bodies (HP:0003798)2.32425328
40Frequent falls (HP:0002359)2.31691048
41Meningitis (HP:0001287)2.29575978
42Loss of speech (HP:0002371)2.29181922
43Purpura (HP:0000979)2.28956261
44Gastrointestinal stroma tumor (HP:0100723)2.28737083
45Petechiae (HP:0000967)2.28475671
46Centrally nucleated skeletal muscle fibers (HP:0003687)2.28101259
47Recurrent skin infections (HP:0001581)2.27697489
48Round ear (HP:0100830)2.26987421
49Nasal polyposis (HP:0100582)2.24638065
50Gastrointestinal infarctions (HP:0005244)2.21130592
51Flat acetabular roof (HP:0003180)2.19165596
52Prolonged bleeding time (HP:0003010)2.16658377
53Amyloidosis (HP:0011034)2.16250245
54Esophageal varix (HP:0002040)2.16231790
55Cerebral aneurysm (HP:0004944)2.14550562
56Recurrent fungal infections (HP:0002841)2.14262531
57Abnormal platelet volume (HP:0011876)2.11966226
58Axonal loss (HP:0003447)2.11360549
59Ulnar bowing (HP:0003031)2.11240550
60Emphysema (HP:0002097)2.10235557
61Abnormal platelet function (HP:0011869)2.09043086
62Impaired platelet aggregation (HP:0003540)2.09043086
63Increased neuronal autofluorescent lipopigment (HP:0002074)2.08766992
64Myocardial infarction (HP:0001658)2.08467012
65Vasculitis (HP:0002633)2.08318038
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07891854
67Recurrent bacterial skin infections (HP:0005406)2.07861753
68Premature rupture of membranes (HP:0001788)2.05564372
69Myositis (HP:0100614)2.05444381
70Mildly elevated creatine phosphokinase (HP:0008180)2.03002617
71Hemorrhage of the eye (HP:0011885)2.02768377
72IgM deficiency (HP:0002850)2.02423841
73Aortic aneurysm (HP:0004942)2.01102137
74Retrobulbar optic neuritis (HP:0100654)2.00567215
75Optic neuritis (HP:0100653)2.00567215
76Increased mean platelet volume (HP:0011877)2.00530339
77Dilatation of the ascending aorta (HP:0005111)2.00382892
78Epistaxis (HP:0000421)1.99955806
79Abnormal delayed hypersensitivity skin test (HP:0002963)1.99869077
80Abnormality of macrophages (HP:0004311)1.99785252
81Metaphyseal cupping (HP:0003021)1.99551597
82Distal lower limb muscle weakness (HP:0009053)1.99039900
83Spondylolisthesis (HP:0003302)1.97397429
84Deep venous thrombosis (HP:0002625)1.96958826
85Mucopolysacchariduria (HP:0008155)1.96647033
86Urinary glycosaminoglycan excretion (HP:0003541)1.96647033
87Hyperactive renin-angiotensin system (HP:0000841)1.96459059
88Gout (HP:0001997)1.96263414
89Hematochezia (HP:0002573)1.95064868
90EMG: myopathic abnormalities (HP:0003458)1.94460371
91Stomatitis (HP:0010280)1.94175090
92Increased IgE level (HP:0003212)1.93777875
93Osteolytic defects of the hand bones (HP:0009699)1.93428432
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.93428432
95Osteomyelitis (HP:0002754)1.92613981
96Abnormality of skeletal muscle fiber size (HP:0012084)1.91290833
97Hypertriglyceridemia (HP:0002155)1.90286932
98Colitis (HP:0002583)1.89779491
99Hepatosplenomegaly (HP:0001433)1.89432936
100Chronic mucocutaneous candidiasis (HP:0002728)1.87771356
101Recurrent cutaneous fungal infections (HP:0011370)1.87771356
102Peritonitis (HP:0002586)1.87523347
103Increased serum ferritin (HP:0003281)1.87214491
104Polygenic inheritance (HP:0010982)1.85686325
105Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85511020
106Cellulitis (HP:0100658)1.84985465
107Pulmonary infiltrates (HP:0002113)1.84759894
108Increased density of long bones (HP:0006392)1.84588316
109Abnormality of purine metabolism (HP:0004352)1.84377855
110Xanthomatosis (HP:0000991)1.82974950
111Urticaria (HP:0001025)1.82866498
112Gastrointestinal inflammation (HP:0004386)1.82806724
113Segmental peripheral demyelination/remyelination (HP:0003481)1.81839873
114Chest pain (HP:0100749)1.81690602
115Inflammation of the large intestine (HP:0002037)1.81264219
116Elevated erythrocyte sedimentation rate (HP:0003565)1.80171188
117Restrictive lung disease (HP:0002091)1.79880707
118Hypertensive crisis (HP:0100735)1.78929399
119Gingival bleeding (HP:0000225)1.78876756
120Sudden death (HP:0001699)1.78653508
121Cervical subluxation (HP:0003308)1.78540078
122Facial diplegia (HP:0001349)1.77912846
123Abnormality of iron homeostasis (HP:0011031)1.75516300
124Thin bony cortex (HP:0002753)1.75366284
125Premature loss of primary teeth (HP:0006323)1.74982209
126Hydroxyprolinuria (HP:0003080)1.74675571
127Abnormality of proline metabolism (HP:0010907)1.74675571
128Abnormality of polysaccharide metabolism (HP:0011012)1.74256185
129Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74256185
130Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74256185
131Upper limb amyotrophy (HP:0009129)1.74035065
132Distal upper limb amyotrophy (HP:0007149)1.74035065
133Vacuolated lymphocytes (HP:0001922)1.71792912
134Hyperammonemia (HP:0001987)1.70615586
135Recurrent viral infections (HP:0004429)1.69614036
136Malnutrition (HP:0004395)1.69172923
137Gingivitis (HP:0000230)1.68590439
138Abnormality of transition element cation homeostasis (HP:0011030)1.68185499
139Hypergammaglobulinemia (HP:0010702)1.67930249
140Dysostosis multiplex (HP:0000943)1.67868183
141Orchitis (HP:0100796)1.66291847
142Bone pain (HP:0002653)1.65107000
143Increased variability in muscle fiber diameter (HP:0003557)1.64684295
144Muscle stiffness (HP:0003552)1.64337983
145Rectal prolapse (HP:0002035)1.63697965
146Abnormality of the calcaneus (HP:0008364)1.61967189
147Hand muscle atrophy (HP:0009130)1.61533972
148Hyperglycinuria (HP:0003108)1.61404798
149Alopecia of scalp (HP:0002293)1.60833622
150Abnormal cartilage morphology (HP:0002763)1.60580265
151Limb-girdle muscle atrophy (HP:0003797)1.59823598
152Abnormality of fatty-acid metabolism (HP:0004359)1.59394624
153Multiple enchondromatosis (HP:0005701)1.59355042
154Aneurysm (HP:0002617)1.58866580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.91723061
2ERN13.44701070
3RIPK43.12180872
4PKN23.08518909
5PRPF4B3.03677480
6TTN2.98050700
7MAP4K12.69198217
8MAP3K102.42066870
9EEF2K2.41844441
10STK102.20398148
11EPHB12.16361792
12CDK122.14097632
13MAP2K32.09424809
14GRK61.90120011
15LRRK21.84872213
16SMG11.84019954
17PTK61.75149674
18RIPK11.73875212
19FGFR41.66299396
20MAP3K131.66123368
21CSK1.63786981
22TGFBR21.48022934
23CDC42BPA1.47414552
24ZAP701.46700735
25TBK11.45150790
26TYK21.44095470
27PAK41.43910704
28MAPKAPK31.42296135
29MAP3K31.41299476
30TAOK21.40308681
31MAP3K111.26843315
32BMX1.25937125
33FLT31.20597098
34PRKG21.19530279
35FES1.11579817
36JAK31.11120082
37DMPK1.09708553
38BCKDK1.07906131
39BTK1.05712625
40ICK1.05586234
41NME21.03912788
42EPHA21.03043405
43MAP3K71.02890109
44PDPK11.02389065
45KDR1.01981034
46SIK11.01836640
47MST41.01437611
48TRPM71.01246959
49RPS6KB21.01024695
50MATK1.00861564
51MARK20.98981139
52BLK0.97888551
53TAOK10.95447214
54TNK20.93875005
55MAP3K60.93574800
56NEK10.88630306
57PIM10.88489432
58PTK20.87529925
59CDK60.87296572
60MAPK110.86802294
61PDGFRA0.85672448
62ITK0.85617084
63JAK10.84074922
64ALK0.82383921
65HCK0.82077242
66MAP3K80.81913822
67MAPK120.80179306
68KIT0.78910329
69FGFR30.78053029
70PDK10.78026362
71MST1R0.76643579
72SIK30.75546041
73PIK3CG0.75139964
74MAP3K20.74794497
75LMTK20.74375891
76JAK20.73918290
77RPS6KA40.72435797
78MAP2K20.70614607
79KSR20.70232000
80OBSCN0.69982759
81CSF1R0.69195859
82HIPK20.67533461
83ARAF0.66631827
84CDK40.66412875
85MTOR0.63922260
86IKBKE0.62042742
87STK380.61949779
88STK240.61779851
89IRAK20.60802066
90LYN0.60702952
91TAOK30.58042635
92IRAK30.56626200
93MAP3K140.56276199
94MAPK70.55686059
95FGR0.55565081
96DDR20.55146700
97RPS6KA20.54633444
98IRAK10.54074099
99TESK20.53335648
100MAP2K60.50907302
101MAP3K10.50372805
102NEK20.50321516
103PIM20.49973630
104IKBKB0.49295330
105PTK2B0.48790646
106MOS0.48631844
107PRKAA20.48076798
108SYK0.47728554
109MARK30.47536882
110LCK0.47265828
111NEK90.46936658
112PRKD20.46705369
113MYLK0.45049232
114MAPKAPK20.44843680
115RET0.44524405
116RPS6KA60.44048462
117CHUK0.43985877
118TESK10.43891532
119TIE10.42990788
120RPS6KC10.42707054
121RPS6KL10.42707054
122PDGFRB0.42371282
123ILK0.41410387
124PDK40.40967773
125PDK30.40967773
126RPS6KA10.40217882
127GSK3A0.40179335
128BMPR20.39899579
129IRAK40.39206853

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34798807
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.24843214
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.95639981
4Leishmaniasis_Homo sapiens_hsa051401.80342638
5Allograft rejection_Homo sapiens_hsa053301.79370369
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77689676
7Fatty acid degradation_Homo sapiens_hsa000711.77641209
8Caffeine metabolism_Homo sapiens_hsa002321.73708395
9Staphylococcus aureus infection_Homo sapiens_hsa051501.69078914
10Graft-versus-host disease_Homo sapiens_hsa053321.68365721
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63704865
12Autoimmune thyroid disease_Homo sapiens_hsa053201.62779650
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.59223876
14Arginine biosynthesis_Homo sapiens_hsa002201.55064854
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.54071392
16Starch and sucrose metabolism_Homo sapiens_hsa005001.44556264
17Malaria_Homo sapiens_hsa051441.43193065
18Carbon metabolism_Homo sapiens_hsa012001.42037695
19Osteoclast differentiation_Homo sapiens_hsa043801.38311497
20Tryptophan metabolism_Homo sapiens_hsa003801.32723646
21Acute myeloid leukemia_Homo sapiens_hsa052211.31600221
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30799294
23B cell receptor signaling pathway_Homo sapiens_hsa046621.27818368
24Insulin resistance_Homo sapiens_hsa049311.26412454
25PPAR signaling pathway_Homo sapiens_hsa033201.21727610
26Pentose phosphate pathway_Homo sapiens_hsa000301.21327688
27Viral myocarditis_Homo sapiens_hsa054161.20432801
28Primary immunodeficiency_Homo sapiens_hsa053401.19765343
29Fat digestion and absorption_Homo sapiens_hsa049751.18515902
30Toxoplasmosis_Homo sapiens_hsa051451.18388871
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18370938
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15897547
33Phagosome_Homo sapiens_hsa041451.15612254
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14711693
35Nitrogen metabolism_Homo sapiens_hsa009101.14694985
36Galactose metabolism_Homo sapiens_hsa000521.13488149
37Chemokine signaling pathway_Homo sapiens_hsa040621.11944171
38Type I diabetes mellitus_Homo sapiens_hsa049401.11265896
39Non-small cell lung cancer_Homo sapiens_hsa052231.11137822
40Legionellosis_Homo sapiens_hsa051341.11118003
41Fructose and mannose metabolism_Homo sapiens_hsa000511.10486227
42Biosynthesis of amino acids_Homo sapiens_hsa012301.09907929
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08805531
44Shigellosis_Homo sapiens_hsa051311.08438686
45Lysine degradation_Homo sapiens_hsa003101.06527159
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06491470
47Asthma_Homo sapiens_hsa053101.05714366
48Adherens junction_Homo sapiens_hsa045201.03282519
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.02381934
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.01419191
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00936197
52Selenocompound metabolism_Homo sapiens_hsa004501.00654197
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99771679
54VEGF signaling pathway_Homo sapiens_hsa043700.98824963
55Complement and coagulation cascades_Homo sapiens_hsa046100.94297844
56Apoptosis_Homo sapiens_hsa042100.92416142
57Fatty acid metabolism_Homo sapiens_hsa012120.92218031
58Herpes simplex infection_Homo sapiens_hsa051680.91997799
59Hematopoietic cell lineage_Homo sapiens_hsa046400.91579352
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.91206265
61Bladder cancer_Homo sapiens_hsa052190.89959831
62Bile secretion_Homo sapiens_hsa049760.89500871
63Renal cell carcinoma_Homo sapiens_hsa052110.88429301
64Rheumatoid arthritis_Homo sapiens_hsa053230.87332539
65Antigen processing and presentation_Homo sapiens_hsa046120.86889801
66Focal adhesion_Homo sapiens_hsa045100.86351002
67Endocytosis_Homo sapiens_hsa041440.86092974
68Other glycan degradation_Homo sapiens_hsa005110.85451570
69Amoebiasis_Homo sapiens_hsa051460.85036215
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.84298575
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.84151592
72Tuberculosis_Homo sapiens_hsa051520.83681364
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83407216
74mTOR signaling pathway_Homo sapiens_hsa041500.83205947
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.83033810
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82168353
77Small cell lung cancer_Homo sapiens_hsa052220.82103349
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81222982
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.80883915
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80872002
81Measles_Homo sapiens_hsa051620.80733055
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.79755795
83Pertussis_Homo sapiens_hsa051330.79443939
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79386853
85Propanoate metabolism_Homo sapiens_hsa006400.78234688
86Platelet activation_Homo sapiens_hsa046110.76472986
87African trypanosomiasis_Homo sapiens_hsa051430.75687420
88Renin-angiotensin system_Homo sapiens_hsa046140.75184383
89TNF signaling pathway_Homo sapiens_hsa046680.74782249
90Proteoglycans in cancer_Homo sapiens_hsa052050.73961404
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.73632918
92GnRH signaling pathway_Homo sapiens_hsa049120.72179188
93Salmonella infection_Homo sapiens_hsa051320.71400991
94T cell receptor signaling pathway_Homo sapiens_hsa046600.70201301
95HIF-1 signaling pathway_Homo sapiens_hsa040660.69528922
96Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69493575
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.69486053
98Pyruvate metabolism_Homo sapiens_hsa006200.69403156
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.69184570
100Influenza A_Homo sapiens_hsa051640.68281777
101Prolactin signaling pathway_Homo sapiens_hsa049170.67941658
102beta-Alanine metabolism_Homo sapiens_hsa004100.67918898
103Notch signaling pathway_Homo sapiens_hsa043300.67655759
104Histidine metabolism_Homo sapiens_hsa003400.67571592
105Insulin signaling pathway_Homo sapiens_hsa049100.67043805
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66983511
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66772698
108Glycerolipid metabolism_Homo sapiens_hsa005610.66468495
109Sulfur relay system_Homo sapiens_hsa041220.66271600
110Lysosome_Homo sapiens_hsa041420.65654156
111Pancreatic cancer_Homo sapiens_hsa052120.65100893
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64333353
113Prion diseases_Homo sapiens_hsa050200.64315324
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63565329
115Thyroid cancer_Homo sapiens_hsa052160.62172343
116HTLV-I infection_Homo sapiens_hsa051660.61699956
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61126188
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60696725
119Endometrial cancer_Homo sapiens_hsa052130.59507956
120ABC transporters_Homo sapiens_hsa020100.59153735
121Hepatitis B_Homo sapiens_hsa051610.59010713
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58476331
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57155848
124Viral carcinogenesis_Homo sapiens_hsa052030.57142545
125Folate biosynthesis_Homo sapiens_hsa007900.56635535
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56025235
127Hepatitis C_Homo sapiens_hsa051600.55609150
128AMPK signaling pathway_Homo sapiens_hsa041520.55065839
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51292432
130Choline metabolism in cancer_Homo sapiens_hsa052310.50846509
131Inositol phosphate metabolism_Homo sapiens_hsa005620.49585098
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48224745
133Phenylalanine metabolism_Homo sapiens_hsa003600.44858827
134Vibrio cholerae infection_Homo sapiens_hsa051100.44620350
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40547825

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