ANP32E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.03414523
2protein localization to kinetochore (GO:0034501)5.40611808
3DNA double-strand break processing (GO:0000729)5.24553103
4negative regulation of DNA-dependent DNA replication (GO:2000104)4.85124279
5negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.73726180
6sister chromatid segregation (GO:0000819)4.72061353
7mitotic sister chromatid cohesion (GO:0007064)4.66382167
8protein localization to chromosome, centromeric region (GO:0071459)4.59716292
9mitotic chromosome condensation (GO:0007076)4.53930110
10mitotic sister chromatid segregation (GO:0000070)4.51685921
11negative regulation of RNA splicing (GO:0033119)4.39505493
12* histone exchange (GO:0043486)4.35100429
13proteasome assembly (GO:0043248)4.29548232
14DNA ligation (GO:0006266)4.28140370
15nuclear pore organization (GO:0006999)4.23892996
16kinetochore assembly (GO:0051382)4.20624140
17DNA strand elongation involved in DNA replication (GO:0006271)4.17560497
18nuclear pore complex assembly (GO:0051292)4.16710964
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.16584858
20replication fork processing (GO:0031297)4.14515549
21negative regulation of mRNA processing (GO:0050686)4.13916007
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.10337022
23DNA topological change (GO:0006265)4.08281974
24regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.02409293
25regulation of mitotic spindle checkpoint (GO:1903504)4.02409293
26mitotic nuclear envelope disassembly (GO:0007077)3.97399256
27DNA strand elongation (GO:0022616)3.94558215
28negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.93425882
29protein K6-linked ubiquitination (GO:0085020)3.86097383
30DNA duplex unwinding (GO:0032508)3.85160237
31DNA geometric change (GO:0032392)3.81957951
32synapsis (GO:0007129)3.81470608
33regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.77774385
34DNA replication-dependent nucleosome assembly (GO:0006335)3.76313991
35DNA replication-dependent nucleosome organization (GO:0034723)3.76313991
36DNA replication initiation (GO:0006270)3.74348149
37membrane disassembly (GO:0030397)3.73691299
38nuclear envelope disassembly (GO:0051081)3.73691299
39mitotic metaphase plate congression (GO:0007080)3.73391577
40alternative mRNA splicing, via spliceosome (GO:0000380)3.72046510
41regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71867454
42kinetochore organization (GO:0051383)3.71070474
43negative regulation of mRNA metabolic process (GO:1903312)3.70827279
44non-recombinational repair (GO:0000726)3.66297863
45double-strand break repair via nonhomologous end joining (GO:0006303)3.66297863
46regulation of mitotic sister chromatid separation (GO:0010965)3.66217992
47regulation of mitotic sister chromatid segregation (GO:0033047)3.66217992
48regulation of sister chromatid segregation (GO:0033045)3.66217992
49regulation of sister chromatid cohesion (GO:0007063)3.62506257
50DNA catabolic process, exonucleolytic (GO:0000738)3.61772557
51telomere maintenance via semi-conservative replication (GO:0032201)3.61065342
52positive regulation of chromosome segregation (GO:0051984)3.59962950
53somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.57547057
54isotype switching (GO:0045190)3.57547057
55somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.57547057
56heterochromatin organization (GO:0070828)3.57539326
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56100498
58pre-miRNA processing (GO:0031054)3.55234657
59maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.54275138
60histone H2A acetylation (GO:0043968)3.52953928
61regulation of centriole replication (GO:0046599)3.52750457
62anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52690140
63mRNA stabilization (GO:0048255)3.51457551
64RNA stabilization (GO:0043489)3.51457551
65negative regulation of histone methylation (GO:0031061)3.50589022
66mitotic recombination (GO:0006312)3.48728026
67cullin deneddylation (GO:0010388)3.48414863
68mitotic G2/M transition checkpoint (GO:0044818)3.47658423
69regulation of DNA endoreduplication (GO:0032875)3.46405145
70response to X-ray (GO:0010165)3.46399274
71regulation of spindle organization (GO:0090224)3.44005393
72protein localization to chromosome (GO:0034502)3.43628275
73regulation of RNA export from nucleus (GO:0046831)3.39801870
74translesion synthesis (GO:0019985)3.39488765
75mRNA splicing, via spliceosome (GO:0000398)3.39377080
76RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.39377080
77purine nucleobase biosynthetic process (GO:0009113)3.39311525
78regulation of nuclear cell cycle DNA replication (GO:0033262)3.38167422
79attachment of spindle microtubules to kinetochore (GO:0008608)3.37576611
80negative regulation of DNA recombination (GO:0045910)3.37559817
81RNA splicing, via transesterification reactions (GO:0000375)3.35854652
82metaphase plate congression (GO:0051310)3.34939196
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34608799
84telomere maintenance via telomerase (GO:0007004)3.33477789
85V(D)J recombination (GO:0033151)3.32811701
86regulation of histone H3-K9 methylation (GO:0051570)3.30964475
87lactate metabolic process (GO:0006089)3.29838747
88dosage compensation (GO:0007549)3.29007550
89DNA strand renaturation (GO:0000733)3.27476828
903-UTR-mediated mRNA stabilization (GO:0070935)3.27152268
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26461199
92DNA conformation change (GO:0071103)3.25112975
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24880789
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.24880789
95telomere maintenance via recombination (GO:0000722)3.24159730
96recombinational repair (GO:0000725)3.23107911
97regulation of chromosome segregation (GO:0051983)3.22361397
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21597452
99double-strand break repair via homologous recombination (GO:0000724)3.20703534
100chromatin assembly or disassembly (GO:0006333)3.19377395
101establishment of chromosome localization (GO:0051303)3.18735618
102negative regulation of ligase activity (GO:0051352)3.16552940
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16552940
104IMP biosynthetic process (GO:0006188)3.16215658
105nucleosome disassembly (GO:0006337)3.15862956
106protein-DNA complex disassembly (GO:0032986)3.15862956
107negative regulation of mitosis (GO:0045839)3.15381726
108glucocorticoid receptor signaling pathway (GO:0042921)3.15090527
109DNA replication checkpoint (GO:0000076)3.14992457
110protein deneddylation (GO:0000338)3.14538468
111positive regulation of mitotic sister chromatid separation (GO:1901970)3.12753945
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12753945
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12753945
114DNA replication-independent nucleosome assembly (GO:0006336)3.12457081
115DNA replication-independent nucleosome organization (GO:0034724)3.12457081
116folic acid-containing compound biosynthetic process (GO:0009396)3.11802576
117chromosome condensation (GO:0030261)3.11434863
118exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11157368
119intra-S DNA damage checkpoint (GO:0031573)3.09586891
120chromatin assembly (GO:0031497)3.08982212
121* ATP-dependent chromatin remodeling (GO:0043044)3.07819915
122ribosome assembly (GO:0042255)3.07382481
123postreplication repair (GO:0006301)3.07346531
124termination of RNA polymerase II transcription (GO:0006369)3.07135879
125spliceosomal tri-snRNP complex assembly (GO:0000244)3.06067144
126nucleobase biosynthetic process (GO:0046112)3.05985550
127pore complex assembly (GO:0046931)3.05963937
128regulation of translational fidelity (GO:0006450)3.05134817
129regulation of helicase activity (GO:0051095)3.03305698
130spindle checkpoint (GO:0031577)3.01459183
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01444911
132spindle assembly checkpoint (GO:0071173)3.00739742
133nucleotide-excision repair, DNA gap filling (GO:0006297)3.00586481
134nuclear envelope organization (GO:0006998)3.00449181
135chromosome segregation (GO:0007059)2.98904764
136positive regulation of RNA splicing (GO:0033120)2.96866476
137negative regulation of chromosome segregation (GO:0051985)2.96294261
138regulation of mRNA stability (GO:0043488)2.95736913
139formation of translation preinitiation complex (GO:0001731)2.94880167
140regulation of DNA damage checkpoint (GO:2000001)2.93882601
141mitotic spindle assembly checkpoint (GO:0007094)2.92231246
142regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91694640
143negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91511838
144negative regulation of sister chromatid segregation (GO:0033046)2.91511838
145negative regulation of mitotic sister chromatid separation (GO:2000816)2.91511838
146negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91511838
147telomere maintenance via telomere lengthening (GO:0010833)2.91281789
148CENP-A containing nucleosome assembly (GO:0034080)2.89990221
149establishment of integrated proviral latency (GO:0075713)2.89653372
150regulation of mitotic spindle organization (GO:0060236)2.87706341
151positive regulation of histone H3-K4 methylation (GO:0051571)2.87037202
152chromatin remodeling at centromere (GO:0031055)2.85937595
153mitotic spindle checkpoint (GO:0071174)2.83554908

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.55238599
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.47620197
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.71256694
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.49687002
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44982787
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.40791320
7MYC_22102868_ChIP-Seq_BL_Human3.26641025
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.23830556
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55452672
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.49156626
11AR_21909140_ChIP-Seq_LNCAP_Human2.38029807
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.37229136
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30508750
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25272204
15CIITA_25753668_ChIP-Seq_RAJI_Human2.23506132
16XRN2_22483619_ChIP-Seq_HELA_Human2.16306628
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14449034
18EWS_26573619_Chip-Seq_HEK293_Human2.10019898
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.00842297
20E2F7_22180533_ChIP-Seq_HELA_Human10.8484040
21VDR_22108803_ChIP-Seq_LS180_Human1.99747434
22VDR_21846776_ChIP-Seq_THP-1_Human1.95443743
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.93989428
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91243365
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91204343
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90435600
27ZNF274_21170338_ChIP-Seq_K562_Hela1.89903497
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.89478892
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89020042
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.88962225
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80998778
32FUS_26573619_Chip-Seq_HEK293_Human1.75940920
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73947403
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73920466
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.65911941
36* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65526134
37* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64683900
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64483099
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62743042
40MYC_18940864_ChIP-ChIP_HL60_Human1.60934978
41TTF2_22483619_ChIP-Seq_HELA_Human1.60681481
42KDM5A_27292631_Chip-Seq_BREAST_Human1.59977265
43* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58145333
44FOXP3_21729870_ChIP-Seq_TREG_Human1.55683789
45* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51559618
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50236625
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48675836
48* VDR_23849224_ChIP-Seq_CD4+_Human1.48577158
49P300_19829295_ChIP-Seq_ESCs_Human1.47592482
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47282806
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46617855
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45098123
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43450561
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43277815
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42458213
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42230657
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37071871
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36189717
59TAF15_26573619_Chip-Seq_HEK293_Human1.35725034
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35567097
61* TCF7_22412390_ChIP-Seq_EML_Mouse1.34916422
62* UTX_26944678_Chip-Seq_JUKART_Human1.32309516
63GABP_19822575_ChIP-Seq_HepG2_Human1.31778923
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.30635836
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.29025741
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27938361
67IGF1R_20145208_ChIP-Seq_DFB_Human1.27223207
68* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26441701
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.25752701
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24255561
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22786537
72* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21472172
73ELK1_19687146_ChIP-ChIP_HELA_Human1.20663798
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19254074
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19000348
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.18625547
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16459119
78DCP1A_22483619_ChIP-Seq_HELA_Human1.16359802
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.15491268
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15334356
81* KDM2B_26808549_Chip-Seq_DND41_Human1.13884129
82* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12539895
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12262383
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11742027
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.11732287
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.11555040
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11264898
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11086279
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10786891
90* CHD1_26751641_Chip-Seq_LNCaP_Human1.09643451
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09471679
92* MAF_26560356_Chip-Seq_TH1_Human1.08891711
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08613491
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08583521
95ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08259056
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.07911019
97* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07742085
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06976217
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06287084
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05546609
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04368011
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04135020
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03828155
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02716235
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02390837
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01620432
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01572856
108* MYB_26560356_Chip-Seq_TH2_Human1.01224768
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00711333
110* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99991968
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99556665
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99278568
113JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98691037
114PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98565608
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97942877
116TFEB_21752829_ChIP-Seq_HELA_Human0.96306137
117IRF1_19129219_ChIP-ChIP_H3396_Human0.96001552
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94623693
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94489990
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94332460
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93676814
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92758235
123CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91737869
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.91638281
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90660343
126* MYB_26560356_Chip-Seq_TH1_Human0.89667686
127SCL_19346495_ChIP-Seq_HPC-7_Human0.89219762
128SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88401663
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87921736
130PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87108427
131VDR_24763502_ChIP-Seq_THP-1_Human0.86729202
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.85685732
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85011867
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84734308
135* NANOG_19829295_ChIP-Seq_ESCs_Human0.84682866
136* SOX2_19829295_ChIP-Seq_ESCs_Human0.84682866
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84648659
138GBX2_23144817_ChIP-Seq_PC3_Human0.83976325
139ELK3_25401928_ChIP-Seq_HUVEC_Human0.83955048
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83312307
141SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82963534
142* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82600013
143CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82580151
144P300_18555785_Chip-Seq_ESCs_Mouse0.82463843
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82463280
146HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81593933
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81534853
148FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.81522161
149STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.81330057
150* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80662371
151OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80288665
152CBP_20019798_ChIP-Seq_JUKART_Human0.80143823
153* NCOR1_26117541_ChIP-Seq_K562_Human0.78494504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.17214956
2MP0003111_abnormal_nucleus_morphology3.99256000
3MP0003693_abnormal_embryo_hatching3.87824939
4MP0004957_abnormal_blastocyst_morpholog3.54537095
5MP0003077_abnormal_cell_cycle3.53466521
6MP0008057_abnormal_DNA_replication3.34320161
7MP0002102_abnormal_ear_morphology3.00814772
8MP0000372_irregular_coat_pigmentation2.99676171
9MP0002938_white_spotting2.53247862
10MP0005076_abnormal_cell_differentiation2.51111023
11MP0001730_embryonic_growth_arrest2.46394021
12MP0010352_gastrointestinal_tract_polyps2.42087523
13MP0008007_abnormal_cellular_replicative2.41144564
14MP0003123_paternal_imprinting2.37316697
15MP0000350_abnormal_cell_proliferation2.31733436
16MP0002396_abnormal_hematopoietic_system2.24768559
17MP0005075_abnormal_melanosome_morpholog2.19162049
18MP0005171_absent_coat_pigmentation2.15579222
19MP0003718_maternal_effect2.15282773
20MP0003941_abnormal_skin_development2.10415351
21MP0003786_premature_aging2.06760129
22MP0008058_abnormal_DNA_repair2.04894236
23MP0008932_abnormal_embryonic_tissue1.98464027
24MP0003121_genomic_imprinting1.94934071
25MP0004808_abnormal_hematopoietic_stem1.90471297
26MP0001672_abnormal_embryogenesis/_devel1.87015654
27MP0005380_embryogenesis_phenotype1.87015654
28MP0001697_abnormal_embryo_size1.84770459
29MP0010307_abnormal_tumor_latency1.84179416
30MP0004197_abnormal_fetal_growth/weight/1.82509475
31MP0003195_calcinosis1.81245790
32MP0003136_yellow_coat_color1.80613360
33MP0003984_embryonic_growth_retardation1.77754639
34MP0000537_abnormal_urethra_morphology1.75460255
35MP0002088_abnormal_embryonic_growth/wei1.75058622
36MP0002085_abnormal_embryonic_tissue1.74924373
37MP0009697_abnormal_copulation1.74587380
38MP0002084_abnormal_developmental_patter1.73079346
39MP0010030_abnormal_orbit_morphology1.64848663
40MP0002080_prenatal_lethality1.64405226
41MP0000703_abnormal_thymus_morphology1.61428503
42MP0006072_abnormal_retinal_apoptosis1.57869688
43MP0003567_abnormal_fetal_cardiomyocyte1.55882554
44MP0003890_abnormal_embryonic-extraembry1.54989767
45MP0001188_hyperpigmentation1.51791144
46MP0005408_hypopigmentation1.50601925
47MP0002086_abnormal_extraembryonic_tissu1.50222665
48MP0008877_abnormal_DNA_methylation1.49956512
49MP0003705_abnormal_hypodermis_morpholog1.40675910
50MP0003763_abnormal_thymus_physiology1.38533506
51MP0005248_abnormal_Harderian_gland1.36294812
52MP0009672_abnormal_birth_weight1.36096546
53MP0009278_abnormal_bone_marrow1.33198116
54MP0002090_abnormal_vision1.32714886
55MP0000490_abnormal_crypts_of1.32714567
56MP0006036_abnormal_mitochondrial_physio1.31051550
57MP0000313_abnormal_cell_death1.30800556
58MP0000428_abnormal_craniofacial_morphol1.30226334
59MP0002751_abnormal_autonomic_nervous1.26266447
60MP0002019_abnormal_tumor_incidence1.26118323
61MP0003806_abnormal_nucleotide_metabolis1.25843000
62MP0009053_abnormal_anal_canal1.25433778
63MP0001293_anophthalmia1.23616416
64MP0000733_abnormal_muscle_development1.22318635
65MP0006054_spinal_hemorrhage1.21489633
66MP0010234_abnormal_vibrissa_follicle1.20229911
67MP0004233_abnormal_muscle_weight1.18133672
68MP0002398_abnormal_bone_marrow1.17777969
69MP0009703_decreased_birth_body1.15409054
70MP0001324_abnormal_eye_pigmentation1.15307479
71MP0001485_abnormal_pinna_reflex1.12572591
72MP0001929_abnormal_gametogenesis1.12526829
73MP0001529_abnormal_vocalization1.10524332
74MP0005253_abnormal_eye_physiology1.09976088
75MP0001849_ear_inflammation1.09223770
76MP0005187_abnormal_penis_morphology1.07947798
77MP0008789_abnormal_olfactory_epithelium1.07885347
78MP0000647_abnormal_sebaceous_gland1.07836362
79MP0000516_abnormal_urinary_system1.07740599
80MP0005367_renal/urinary_system_phenotyp1.07740599
81MP0002653_abnormal_ependyma_morphology1.07032895
82MP0003646_muscle_fatigue1.06779923
83MP0006035_abnormal_mitochondrial_morpho1.05256630
84MP0002722_abnormal_immune_system1.04531899
85MP0005391_vision/eye_phenotype1.04143982
86MP0005395_other_phenotype1.02046599
87MP0003935_abnormal_craniofacial_develop1.01649922
88MP0005174_abnormal_tail_pigmentation0.99957554
89MP0003122_maternal_imprinting0.99063460
90MP0002837_dystrophic_cardiac_calcinosis0.97965123
91MP0009333_abnormal_splenocyte_physiolog0.97558333
92MP0002210_abnormal_sex_determination0.97345097
93MP0005397_hematopoietic_system_phenotyp0.96184217
94MP0001545_abnormal_hematopoietic_system0.96184217
95MP0001177_atelectasis0.95899914
96MP0000653_abnormal_sex_gland0.95401612
97MP0002254_reproductive_system_inflammat0.93975211
98MP0005551_abnormal_eye_electrophysiolog0.93902863
99MP0002092_abnormal_eye_morphology0.93815552
100MP0001119_abnormal_female_reproductive0.93371843
101MP0001984_abnormal_olfaction0.92087783
102MP0002877_abnormal_melanocyte_morpholog0.92007513
103MP0003115_abnormal_respiratory_system0.91971275
104MP0002095_abnormal_skin_pigmentation0.90902761
105MP0001286_abnormal_eye_development0.90673701
106MP0003303_peritoneal_inflammation0.90483673
107MP0002925_abnormal_cardiovascular_devel0.89911527
108MP0003937_abnormal_limbs/digits/tail_de0.89652306
109MP0005499_abnormal_olfactory_system0.89440469
110MP0005394_taste/olfaction_phenotype0.89440469
111MP0004215_abnormal_myocardial_fiber0.89432235
112MP0003861_abnormal_nervous_system0.89243576
113MP0000427_abnormal_hair_cycle0.89192819
114MP0001145_abnormal_male_reproductive0.88155256
115MP0002233_abnormal_nose_morphology0.88009482
116MP0003300_gastrointestinal_ulcer0.87046502
117MP0003119_abnormal_digestive_system0.86362296
118MP0002697_abnormal_eye_size0.85563945
119MP0001915_intracranial_hemorrhage0.85508313
120MP0003787_abnormal_imprinting0.84630830
121MP0000015_abnormal_ear_pigmentation0.83566164
122MP0000689_abnormal_spleen_morphology0.82964929
123MP0004133_heterotaxia0.80597111
124MP0003943_abnormal_hepatobiliary_system0.78838163
125MP0002736_abnormal_nociception_after0.78245389
126MP0008770_decreased_survivor_rate0.78057595
127MP0000358_abnormal_cell_content/0.76656192
128MP0002429_abnormal_blood_cell0.76153456
129MP0006292_abnormal_olfactory_placode0.75877851
130MP0002111_abnormal_tail_morphology0.75411935
131MP0003011_delayed_dark_adaptation0.74809068
132MP0002932_abnormal_joint_morphology0.73555436
133MP0000579_abnormal_nail_morphology0.73352096
134MP0000432_abnormal_head_morphology0.73329084
135MP0008872_abnormal_physiological_respon0.71419930
136MP0000266_abnormal_heart_morphology0.70928777
137MP0000371_diluted_coat_color0.70284090
138MP0010630_abnormal_cardiac_muscle0.69186576
139MP0003221_abnormal_cardiomyocyte_apopto0.69152052
140MP0005384_cellular_phenotype0.69151439
141MP0001784_abnormal_fluid_regulation0.68777163
142MP0005621_abnormal_cell_physiology0.67618574
143MP0000465_gastrointestinal_hemorrhage0.67520997
144MP0000716_abnormal_immune_system0.67440787
145MP0004147_increased_porphyrin_level0.67404148
146MP0002081_perinatal_lethality0.67248329
147MP0003137_abnormal_impulse_conducting0.66604325
148MP0002114_abnormal_axial_skeleton0.66577845
149MP0003186_abnormal_redox_activity0.66126334
150MP0002166_altered_tumor_susceptibility0.65557191
151MP0004084_abnormal_cardiac_muscle0.65243935
152MP0003698_abnormal_male_reproductive0.64787443
153MP0003950_abnormal_plasma_membrane0.64429017
154MP0000631_abnormal_neuroendocrine_gland0.64227546
155MP0003755_abnormal_palate_morphology0.63788349

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the uvula (HP:0010293)3.92626799
2Abnormality of the ileum (HP:0001549)3.87026795
3Volvulus (HP:0002580)3.84201695
4Increased nuchal translucency (HP:0010880)3.76058425
5Abnormality of the preputium (HP:0100587)3.61775372
6Pendular nystagmus (HP:0012043)3.31490533
7Short 4th metacarpal (HP:0010044)3.26521489
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26521489
9Abnormality of the duodenum (HP:0002246)3.25538055
10Ependymoma (HP:0002888)3.21531592
11Nephroblastoma (Wilms tumor) (HP:0002667)3.15511153
12Congenital stationary night blindness (HP:0007642)3.08297990
13Embryonal renal neoplasm (HP:0011794)3.05275395
14Medulloblastoma (HP:0002885)3.04666901
15Intestinal atresia (HP:0011100)3.03308916
16Hyperacusis (HP:0010780)3.00995323
17Sloping forehead (HP:0000340)2.85509272
18Colon cancer (HP:0003003)2.84735291
19Renal duplication (HP:0000075)2.79547467
20Proximal placement of thumb (HP:0009623)2.76268018
21Bony spicule pigmentary retinopathy (HP:0007737)2.70373049
22Clubbing of toes (HP:0100760)2.68786946
23Neoplasm of the adrenal gland (HP:0100631)2.64221016
24Deviation of the thumb (HP:0009603)2.61942132
25Abnormality of the fingertips (HP:0001211)2.60998213
26Neoplasm of the adrenal cortex (HP:0100641)2.59871265
27Abnormal number of incisors (HP:0011064)2.59055940
28Pancreatic islet-cell hyperplasia (HP:0004510)2.55618335
29Astrocytoma (HP:0009592)2.52854837
30Abnormality of the astrocytes (HP:0100707)2.52854837
31Abnormality of the 4th metacarpal (HP:0010012)2.47104971
32Hypoplasia of the fovea (HP:0007750)2.45236356
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.45236356
34Patellar aplasia (HP:0006443)2.43149464
35Long eyelashes (HP:0000527)2.39715776
36Methylmalonic acidemia (HP:0002912)2.35704334
37Basal cell carcinoma (HP:0002671)2.33472248
38Selective tooth agenesis (HP:0001592)2.33239708
39Cutis marmorata (HP:0000965)2.33157947
40Supernumerary spleens (HP:0009799)2.32825533
41Aplasia/Hypoplasia of the patella (HP:0006498)2.31619801
42Abnormality of the fovea (HP:0000493)2.25712812
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25084453
44Atresia of the external auditory canal (HP:0000413)2.24540646
45Posterior subcapsular cataract (HP:0007787)2.23729980
46Absent radius (HP:0003974)2.23421803
47Rhabdomyosarcoma (HP:0002859)2.23330936
48Triphalangeal thumb (HP:0001199)2.22880571
49Pancreatic cysts (HP:0001737)2.22809708
50Overriding aorta (HP:0002623)2.22601815
51Abnormality of methionine metabolism (HP:0010901)2.21254348
52Abnormality of chromosome segregation (HP:0002916)2.21151504
53Abnormality of B cell number (HP:0010975)2.20739151
54B lymphocytopenia (HP:0010976)2.20739151
55Prominent nose (HP:0000448)2.20666034
56Aqueductal stenosis (HP:0002410)2.19531780
57Breast carcinoma (HP:0003002)2.18498414
58Neoplasm of striated muscle (HP:0009728)2.18175017
59Birth length less than 3rd percentile (HP:0003561)2.16544860
60T lymphocytopenia (HP:0005403)2.15949887
61Glioma (HP:0009733)2.15369792
62Neoplasm of the colon (HP:0100273)2.12358322
63High pitched voice (HP:0001620)2.12090217
64Acute encephalopathy (HP:0006846)2.11998061
65Abnormal rod and cone electroretinograms (HP:0008323)2.10618506
66Acute necrotizing encephalopathy (HP:0006965)2.10386991
67Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09709091
68Chromsome breakage (HP:0040012)2.09665342
69Absent forearm bone (HP:0003953)2.09119525
70Aplasia involving forearm bones (HP:0009822)2.09119525
71Insomnia (HP:0100785)2.07417980
72Elfin facies (HP:0004428)2.07119514
73Overlapping toe (HP:0001845)2.06789963
74Deep philtrum (HP:0002002)2.05611509
75Trigonocephaly (HP:0000243)2.05389771
76Progressive macrocephaly (HP:0004481)2.05294276
77Pancreatic fibrosis (HP:0100732)2.04848201
78Reticulocytopenia (HP:0001896)2.04519921
79Ovarian neoplasm (HP:0100615)2.04045908
80True hermaphroditism (HP:0010459)2.03472724
81Pseudobulbar signs (HP:0002200)2.01357023
82Abnormality of chromosome stability (HP:0003220)2.00984553
83Gastrointestinal atresia (HP:0002589)2.00724808
84Broad palm (HP:0001169)2.00361169
85Abnormality of glycolysis (HP:0004366)1.99218683
86Cafe-au-lait spot (HP:0000957)1.98387893
87Pelvic girdle muscle weakness (HP:0003749)1.98240134
88Obsessive-compulsive behavior (HP:0000722)1.97055369
89Dandy-Walker malformation (HP:0001305)1.96116600
90Increased CSF lactate (HP:0002490)1.95925000
91Chorioretinal atrophy (HP:0000533)1.95504352
92Aplasia/Hypoplasia of the sternum (HP:0006714)1.94073173
93Renovascular hypertension (HP:0100817)1.94000212
94Skin tags (HP:0010609)1.93283429
95Ectopic kidney (HP:0000086)1.93188858
96Embryonal neoplasm (HP:0002898)1.92975227
97Absent thumb (HP:0009777)1.92448909
98Pointed chin (HP:0000307)1.90603572
99Increased hepatocellular lipid droplets (HP:0006565)1.90330214
100Neoplasm of the oral cavity (HP:0100649)1.89229989
101Abnormality of T cell number (HP:0011839)1.89061921
102Combined immunodeficiency (HP:0005387)1.89040927
103Facial hemangioma (HP:0000329)1.87929962
104Horseshoe kidney (HP:0000085)1.87430645
105Abnormality of the intervertebral disk (HP:0005108)1.86720624
106Patchy hypopigmentation of hair (HP:0011365)1.86429525
107Hypoglycemic seizures (HP:0002173)1.85288594
108Gastrointestinal carcinoma (HP:0002672)1.85074015
109Malignant gastrointestinal tract tumors (HP:0006749)1.85074015
110Increased density of long bones (HP:0006392)1.85002430
111Vertebral arch anomaly (HP:0008438)1.84171407
112Truncal obesity (HP:0001956)1.84087625
113Hyperglycinemia (HP:0002154)1.83404499
114Small hand (HP:0200055)1.83166318
115Myelodysplasia (HP:0002863)1.82693575
116Hypoplastic pelvis (HP:0008839)1.82224043
117Abnormality of serum amino acid levels (HP:0003112)1.81183898
118Methylmalonic aciduria (HP:0012120)1.81180208
119Ankyloglossia (HP:0010296)1.79452551
120Abnormality of the anterior horn cell (HP:0006802)1.79146224
121Degeneration of anterior horn cells (HP:0002398)1.79146224
122Shoulder girdle muscle weakness (HP:0003547)1.77584250
123Astigmatism (HP:0000483)1.77391686
124Abnormal lung lobation (HP:0002101)1.77239527
125Abnormality of the pancreatic islet cells (HP:0006476)1.76962419
126Abnormality of endocrine pancreas physiology (HP:0012093)1.76962419
127Cortical dysplasia (HP:0002539)1.76951565
128Supernumerary ribs (HP:0005815)1.76614441
129Intestinal polyposis (HP:0200008)1.76114538
130Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75701394
131Abnormality of the fetal cardiovascular system (HP:0010948)1.75687818
132Abnormal umbilical cord blood vessels (HP:0011403)1.75687818
133Single umbilical artery (HP:0001195)1.75687818
134Type II diabetes mellitus (HP:0005978)1.75441985
135Abnormality of the labia minora (HP:0012880)1.75204213
136Sacral dimple (HP:0000960)1.74877537
137Preauricular skin tag (HP:0000384)1.74184022
138Heterotopia (HP:0002282)1.74120393
139Hyperinsulinemic hypoglycemia (HP:0000825)1.73996604
140Severe combined immunodeficiency (HP:0004430)1.73337633
141Molar tooth sign on MRI (HP:0002419)1.72677882
142Abnormality of midbrain morphology (HP:0002418)1.72677882
143Mitochondrial inheritance (HP:0001427)1.72641174
144Oligodactyly (hands) (HP:0001180)1.72478437
145Abnormality of cells of the erythroid lineage (HP:0012130)1.72349911
146Aplasia/Hypoplasia of the macula (HP:0008059)1.71647062
147Rectal prolapse (HP:0002035)1.71401944
148Abnormality of the carotid arteries (HP:0005344)1.71378725
149Broad thumb (HP:0011304)1.70974775
150Macroorchidism (HP:0000053)1.70764295
151Meckel diverticulum (HP:0002245)1.70630494
152Acute lymphatic leukemia (HP:0006721)1.70601532
153Long clavicles (HP:0000890)1.70377526
154Abnormality of glycine metabolism (HP:0010895)1.70312746
155Abnormality of serine family amino acid metabolism (HP:0010894)1.70312746
156Hypothermia (HP:0002045)1.69348035
157Abnormality of oral frenula (HP:0000190)1.69139409
158Adenoma sebaceum (HP:0009720)1.68404421
159Angiofibromas (HP:0010615)1.68404421
160Preaxial hand polydactyly (HP:0001177)1.68354957
161Hypoplastic female external genitalia (HP:0012815)1.67132276
162Increased serum pyruvate (HP:0003542)1.66866508
163Abnormal auditory evoked potentials (HP:0006958)1.66779349
164Recurrent viral infections (HP:0004429)1.66666464
165Intestinal polyp (HP:0005266)1.66492718
166Abnormal number of erythroid precursors (HP:0012131)1.66258062
167Small intestinal stenosis (HP:0012848)1.66242092
168Duodenal stenosis (HP:0100867)1.66242092
169Scotoma (HP:0000575)1.66179823
170Abnormal mitochondria in muscle tissue (HP:0008316)1.65852326
171Bicuspid aortic valve (HP:0001647)1.65400490
172Asplenia (HP:0001746)1.64206595
173White forelock (HP:0002211)1.63252599
174Oligohydramnios (HP:0001562)1.62255920

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88401944
2TRIM283.39471918
3CDK123.36192509
4EEF2K3.35930468
5MAP3K103.31899644
6NEK23.15696495
7BUB12.90453714
8PKN22.66815823
9WNK32.58404470
10WEE12.55163843
11NEK12.46708303
12ERBB32.40201383
13TNIK2.34172251
14TRIB32.33129400
15MST42.30116945
16NUAK12.27841188
17FRK2.25198580
18MKNK12.18721467
19TSSK62.10155298
20BMPR1B2.00391426
21TTK1.99485120
22STK101.91519273
23ZAK1.90549235
24SRPK11.87741213
25PASK1.83229642
26TESK21.80749943
27PLK21.77520712
28VRK21.77318948
29CDK41.75433518
30RPS6KB21.72128706
31MKNK21.68341674
32EIF2AK11.66409870
33ATR1.65941024
34ALK1.65597968
35TAF11.63570660
36RPS6KA41.61389777
37BRD41.48556615
38CHEK11.46249252
39CDK61.45341941
40PLK11.43658342
41AURKB1.42604894
42PLK31.42421782
43SIK31.36733383
44MAP4K11.34845317
45EIF2AK21.33567773
46BRSK11.29643526
47PBK1.29224426
48CDK71.27787959
49MAP3K81.26798556
50LRRK21.26053603
51BCR1.24682880
52STK41.22396734
53CHEK21.21976409
54SCYL21.19851556
55MAP4K21.16144954
56PAK41.15497561
57CCNB11.07524053
58CDK21.04040271
59GRK61.03917811
60ATM1.02808694
61FGFR21.01982857
62BRSK21.01441814
63STK161.00546338
64TGFBR10.98573968
65DYRK30.88312814
66CLK10.87634946
67STK38L0.86200234
68CDK10.85728706
69STK390.85690072
70STK30.83858224
71PTK60.82193503
72MTOR0.82095898
73SIK20.81120096
74ACVR1B0.78181234
75MELK0.78101518
76CSNK1G10.74929821
77FGFR10.73315824
78NLK0.73131398
79AURKA0.72841602
80ILK0.71368143
81GRK10.70921890
82OXSR10.69768996
83UHMK10.67804275
84PLK40.67520463
85HIPK20.66338484
86EIF2AK30.65803520
87PNCK0.62153251
88CDK80.61495806
89CSNK1G20.60571739
90CSNK1G30.59688446
91PDK20.57913584
92MINK10.57587402
93ICK0.57254748
94PRKDC0.55921271
95LATS10.55510911
96TTN0.55071325
97VRK10.54930931
98CSNK1D0.54618671
99PAK20.53123661
100PIM10.52346451
101MAPK140.52285373
102BTK0.51537020
103NME10.51185518
104MAPK130.50561684
105MARK30.48485593
106PAK30.47846980
107CSNK1E0.47840533
108AKT20.47157214
109FER0.46498828
110PDGFRA0.46315136
111ITK0.45756688
112CSNK2A20.45282579
113TYRO30.44509220
114TESK10.44230662
115CSNK1A1L0.43923327
116CDK90.43557836
117DMPK0.43498147
118INSRR0.39782398
119CDK11A0.38349046
120CDK150.36996613
121GSK3B0.36487533
122PRKCG0.36296041
123MAPK90.35646252
124DYRK20.35174561
125TGFBR20.35060010
126CSF1R0.34970201
127PDGFRB0.34045298
128PAK10.33970157
129CASK0.33946974
130CDK140.33582531
131CDK30.33473550
132CDK180.33443821
133CSNK2A10.31733344
134AKT10.31727582
135ZAP700.30739357
136ADRBK20.30006895
137RPS6KA10.29636196
138PRKCI0.29224250
139DYRK1B0.28161941
140BRAF0.27808768
141MAPKAPK20.27673555
142FGFR30.27603283
143SYK0.27416415
144DAPK10.26870466
145ERBB20.26733728
146WNK40.24062031
147PRKCE0.23088056
148YES10.19264288
149GRK50.17153330
150MAP3K40.16866098
151FLT30.15224277
152ERBB40.15131612
153PKN10.14037232

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.29182638
2Spliceosome_Homo sapiens_hsa030403.47308917
3Mismatch repair_Homo sapiens_hsa034303.44490895
4Protein export_Homo sapiens_hsa030603.37214249
5Cell cycle_Homo sapiens_hsa041103.02917761
6RNA transport_Homo sapiens_hsa030132.78657696
7Base excision repair_Homo sapiens_hsa034102.64710952
8mRNA surveillance pathway_Homo sapiens_hsa030152.36379603
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28044962
10Phototransduction_Homo sapiens_hsa047442.27754763
11Non-homologous end-joining_Homo sapiens_hsa034502.23765665
12Vitamin B6 metabolism_Homo sapiens_hsa007502.21364579
13Propanoate metabolism_Homo sapiens_hsa006402.20439371
14Homologous recombination_Homo sapiens_hsa034402.13395836
15Nucleotide excision repair_Homo sapiens_hsa034202.11712295
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07788777
17One carbon pool by folate_Homo sapiens_hsa006701.86610781
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83856148
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75949646
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.72682272
21Ribosome_Homo sapiens_hsa030101.70045649
22Steroid biosynthesis_Homo sapiens_hsa001001.69254892
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68221275
24RNA degradation_Homo sapiens_hsa030181.67586748
25Fanconi anemia pathway_Homo sapiens_hsa034601.59900427
26Primary immunodeficiency_Homo sapiens_hsa053401.55938932
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55706056
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53300417
29Chronic myeloid leukemia_Homo sapiens_hsa052201.50628589
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44560125
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44106692
32Oocyte meiosis_Homo sapiens_hsa041141.39028859
33Colorectal cancer_Homo sapiens_hsa052101.37851359
34p53 signaling pathway_Homo sapiens_hsa041151.37807856
35Fatty acid elongation_Homo sapiens_hsa000621.35725254
36MicroRNAs in cancer_Homo sapiens_hsa052061.32475786
37Pyruvate metabolism_Homo sapiens_hsa006201.32438056
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29987303
39HTLV-I infection_Homo sapiens_hsa051661.27676181
40Viral carcinogenesis_Homo sapiens_hsa052031.23928182
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23041438
42Non-small cell lung cancer_Homo sapiens_hsa052231.20443803
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16116212
44Antigen processing and presentation_Homo sapiens_hsa046121.13500879
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13276666
46Thyroid cancer_Homo sapiens_hsa052161.11317985
47Epstein-Barr virus infection_Homo sapiens_hsa051691.08254812
48Small cell lung cancer_Homo sapiens_hsa052221.07613937
49mTOR signaling pathway_Homo sapiens_hsa041501.07390195
50RNA polymerase_Homo sapiens_hsa030201.06742715
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03641327
52Selenocompound metabolism_Homo sapiens_hsa004501.03629915
53Pyrimidine metabolism_Homo sapiens_hsa002401.03057299
54Parkinsons disease_Homo sapiens_hsa050121.01391146
55Basal transcription factors_Homo sapiens_hsa030221.01098973
56Oxidative phosphorylation_Homo sapiens_hsa001900.99750492
57Endometrial cancer_Homo sapiens_hsa052130.99383904
58Basal cell carcinoma_Homo sapiens_hsa052170.98279920
59Herpes simplex infection_Homo sapiens_hsa051680.96098087
60Viral myocarditis_Homo sapiens_hsa054160.95552065
61Notch signaling pathway_Homo sapiens_hsa043300.93825870
62Butanoate metabolism_Homo sapiens_hsa006500.93375509
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92273844
64Pancreatic cancer_Homo sapiens_hsa052120.90860379
65T cell receptor signaling pathway_Homo sapiens_hsa046600.90802258
66Proteasome_Homo sapiens_hsa030500.90008136
67Hippo signaling pathway_Homo sapiens_hsa043900.88811183
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87572851
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.86422534
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86251657
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86172082
72Carbon metabolism_Homo sapiens_hsa012000.84275618
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83026494
74B cell receptor signaling pathway_Homo sapiens_hsa046620.82081345
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81788420
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81262472
77Systemic lupus erythematosus_Homo sapiens_hsa053220.81172314
78Hepatitis B_Homo sapiens_hsa051610.80821773
79Glioma_Homo sapiens_hsa052140.80349955
80Glutathione metabolism_Homo sapiens_hsa004800.79283567
81Prostate cancer_Homo sapiens_hsa052150.78745197
82Acute myeloid leukemia_Homo sapiens_hsa052210.78319701
83Adherens junction_Homo sapiens_hsa045200.73892596
84Lysine degradation_Homo sapiens_hsa003100.72502664
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.71434533
86Huntingtons disease_Homo sapiens_hsa050160.70520350
87Proteoglycans in cancer_Homo sapiens_hsa052050.70372735
88Renal cell carcinoma_Homo sapiens_hsa052110.69621451
89Wnt signaling pathway_Homo sapiens_hsa043100.67914980
90Fatty acid metabolism_Homo sapiens_hsa012120.67433012
91Hedgehog signaling pathway_Homo sapiens_hsa043400.66825240
92Alcoholism_Homo sapiens_hsa050340.65563463
93Pathways in cancer_Homo sapiens_hsa052000.65360128
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64905266
95HIF-1 signaling pathway_Homo sapiens_hsa040660.62229109
96Tryptophan metabolism_Homo sapiens_hsa003800.61550950
97Fatty acid degradation_Homo sapiens_hsa000710.61282128
98Caffeine metabolism_Homo sapiens_hsa002320.60254793
99Bladder cancer_Homo sapiens_hsa052190.59793091
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59631766
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59627812
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.58868523
103VEGF signaling pathway_Homo sapiens_hsa043700.58627047
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58272305
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57116869
106beta-Alanine metabolism_Homo sapiens_hsa004100.56861526
107Metabolic pathways_Homo sapiens_hsa011000.55641602
108FoxO signaling pathway_Homo sapiens_hsa040680.55508485
109Apoptosis_Homo sapiens_hsa042100.55134006
110Peroxisome_Homo sapiens_hsa041460.54713449
111Folate biosynthesis_Homo sapiens_hsa007900.54541820
112Purine metabolism_Homo sapiens_hsa002300.52283170
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52105515
114Biosynthesis of amino acids_Homo sapiens_hsa012300.50938734
115Measles_Homo sapiens_hsa051620.50885861
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50685880
117Shigellosis_Homo sapiens_hsa051310.50365098
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50276355
119TGF-beta signaling pathway_Homo sapiens_hsa043500.49731896
120Pentose phosphate pathway_Homo sapiens_hsa000300.45695213
121Platelet activation_Homo sapiens_hsa046110.44841619
122N-Glycan biosynthesis_Homo sapiens_hsa005100.44327399
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44023578
124Nitrogen metabolism_Homo sapiens_hsa009100.43498078
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.43156605
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42683358
127Melanoma_Homo sapiens_hsa052180.41161074
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41099035
129Alzheimers disease_Homo sapiens_hsa050100.40718157
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40594708
131Estrogen signaling pathway_Homo sapiens_hsa049150.39274039
132Focal adhesion_Homo sapiens_hsa045100.38687817
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37837550
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36438507
135Tight junction_Homo sapiens_hsa045300.36351744
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34783186
137Sulfur metabolism_Homo sapiens_hsa009200.34609920
138AMPK signaling pathway_Homo sapiens_hsa041520.33711841
139Legionellosis_Homo sapiens_hsa051340.31308574
140Ether lipid metabolism_Homo sapiens_hsa005650.31081933
141Retinol metabolism_Homo sapiens_hsa008300.30611843
142Toxoplasmosis_Homo sapiens_hsa051450.29886328
143ErbB signaling pathway_Homo sapiens_hsa040120.29765771
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.29663541
145Insulin signaling pathway_Homo sapiens_hsa049100.28412335
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28223729
147Arginine and proline metabolism_Homo sapiens_hsa003300.27150429
148Chemokine signaling pathway_Homo sapiens_hsa040620.27142788
149Hematopoietic cell lineage_Homo sapiens_hsa046400.27007093
150Vitamin digestion and absorption_Homo sapiens_hsa049770.24949313
151Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23492579
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.20232632
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17982236
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16612984
155Linoleic acid metabolism_Homo sapiens_hsa005910.14923644
156Regulation of autophagy_Homo sapiens_hsa041400.14620077
157Fat digestion and absorption_Homo sapiens_hsa049750.12368715
158Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11801504
159Circadian rhythm_Homo sapiens_hsa047100.11731248
160Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.11249929
161Primary bile acid biosynthesis_Homo sapiens_hsa001200.10406925

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