ANP32D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphoprotein 32 (PP32) is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers. The protein encoded by this gene is one of at least two proteins that are similar in amino acid sequence to PP32 and are part of the same acidic nuclear phosphoprotein gene family. However, unlike PP32, the encoded protein is tumorigenic. The tumor suppressor function of PP32 has been localized to a 25 amino acid region that is absent in the protein encoded by this gene. This gene does not contain introns. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)9.51791363
2secretory granule organization (GO:0033363)8.87400934
3regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)8.47136501
4regulation of mitochondrial translation (GO:0070129)7.84636339
5platelet formation (GO:0030220)7.60576955
6fusion of sperm to egg plasma membrane (GO:0007342)6.82867283
7negative regulation of signal transduction by p53 class mediator (GO:1901797)6.07291259
8cytochrome complex assembly (GO:0017004)6.04754139
9negative regulation of translational initiation (GO:0045947)5.93319026
10positive regulation of macrophage differentiation (GO:0045651)5.89827714
11negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)5.83401443
12regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)5.69426456
13negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)5.48350477
14production of molecular mediator involved in inflammatory response (GO:0002532)5.36602439
15myeloid cell development (GO:0061515)5.19892250
16plasma membrane fusion (GO:0045026)5.17318146
17piRNA metabolic process (GO:0034587)5.00617451
18regulation of necrotic cell death (GO:0010939)4.88246120
19regulation of necroptotic process (GO:0060544)4.79652603
20regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902229)4.52162603
21regulation of B cell differentiation (GO:0045577)4.50769879
22positive regulation of mast cell activation involved in immune response (GO:0033008)4.39773476
23positive regulation of mast cell degranulation (GO:0043306)4.39773476
24pseudouridine synthesis (GO:0001522)4.33513782
25necroptotic process (GO:0070266)4.30993088
26protein kinase B signaling (GO:0043491)4.11849112
27fibril organization (GO:0097435)4.10420490
28regulation of epidermal growth factor-activated receptor activity (GO:0007176)4.08901592
29T cell apoptotic process (GO:0070231)4.08188913
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.98830183
31regulation of translation in response to stress (GO:0043555)3.91337520
32regulation of nucleobase-containing compound transport (GO:0032239)3.88485690
33negative regulation of chemokine production (GO:0032682)3.82633555
34pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.82265869
35positive regulation of fat cell differentiation (GO:0045600)3.82028435
36sequestering of extracellular ligand from receptor (GO:0035581)3.79071191
37negative regulation of complement activation (GO:0045916)3.78790635
38positive regulation of mast cell activation (GO:0033005)3.68298197
39regulation of signal transduction by p53 class mediator (GO:1901796)3.68175276
40negative regulation of membrane potential (GO:0045837)3.67208597
41glucose 6-phosphate metabolic process (GO:0051156)3.55908292
42erythrocyte maturation (GO:0043249)3.52825827
43cellular protein catabolic process (GO:0044257)3.52639276
44lymphocyte apoptotic process (GO:0070227)3.47653206
45positive regulation of translation (GO:0045727)3.45799467
46protein complex biogenesis (GO:0070271)3.44535126
47negative regulation of protein activation cascade (GO:2000258)3.39037064
48positive regulation of response to DNA damage stimulus (GO:2001022)3.37568963
49response to food (GO:0032094)3.36532267
50regulation of translational initiation (GO:0006446)3.34964592
51ribosomal small subunit biogenesis (GO:0042274)3.31100540
52multicellular organism reproduction (GO:0032504)3.27435397
53regulation of macrophage differentiation (GO:0045649)3.21627855
54lamellipodium assembly (GO:0030032)3.17062884
55pyrimidine nucleotide catabolic process (GO:0006244)3.15822578
56DNA packaging (GO:0006323)3.14143514
57regulation of chemokine biosynthetic process (GO:0045073)3.10783556
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.06823586
59positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.05000271
60detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.02459383
61regulation of gamma-delta T cell differentiation (GO:0045586)3.01543662
62mitochondrial respiratory chain complex assembly (GO:0033108)2.99697027
63lymph vessel development (GO:0001945)2.99526797
64negative regulation of response to DNA damage stimulus (GO:2001021)2.97705839
65negative regulation of humoral immune response (GO:0002921)2.97260486
66regulation of memory T cell differentiation (GO:0043380)2.96204871
67neutrophil activation (GO:0042119)2.94523237
68lipoxygenase pathway (GO:0019372)2.91840705
69protein insertion into membrane (GO:0051205)2.88429656
70neural tube formation (GO:0001841)2.88038041
71positive regulation of mitochondrial membrane permeability (GO:0035794)2.87865723
72leukotriene biosynthetic process (GO:0019370)2.87245551
73ubiquinone biosynthetic process (GO:0006744)2.87032167
74oligodendrocyte development (GO:0014003)2.86719028
75rRNA modification (GO:0000154)2.84896867
76lamellipodium organization (GO:0097581)2.81619410
77regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.79331757
78positive regulation of gamma-delta T cell activation (GO:0046645)2.75518690
79rRNA catabolic process (GO:0016075)2.74366474
80programmed necrotic cell death (GO:0097300)2.72747269
81carnitine metabolic process (GO:0009437)2.71544362
82positive regulation of leukocyte degranulation (GO:0043302)2.64221938
83signal peptide processing (GO:0006465)2.63541456
84positive regulation of T cell apoptotic process (GO:0070234)2.61757465
85cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.60782713
86DNA replication-dependent nucleosome assembly (GO:0006335)2.58273907
87DNA replication-dependent nucleosome organization (GO:0034723)2.58273907
88cellular response to interferon-beta (GO:0035458)2.58122926
89granulocyte activation (GO:0036230)2.56731475
90amino-acid betaine metabolic process (GO:0006577)2.55433345
91sperm-egg recognition (GO:0035036)2.54909496
92RNA localization (GO:0006403)16.4514529
93signal complex assembly (GO:0007172)14.9088887
94positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)12.2650076
95negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 12.2488857
96megakaryocyte development (GO:0035855)11.4743915
97positive regulation of translational initiation (GO:0045948)11.0803491
98regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 10.5147336
99negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)10.1354004
100positive regulation of signal transduction by p53 class mediator (GO:1901798)10.0788531

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human7.55355222
2AR_21572438_ChIP-Seq_LNCaP_Human4.02177332
3EZH2_22144423_ChIP-Seq_EOC_Human3.69880092
4VDR_22108803_ChIP-Seq_LS180_Human2.91130850
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86450907
6CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.69943045
7SRY_22984422_ChIP-ChIP_TESTIS_Rat2.58840377
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56735575
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.54924099
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43451500
11RNF2_27304074_Chip-Seq_NSC_Mouse2.37058934
12TBX3_20139965_ChIP-Seq_ESCs_Mouse2.22835966
13TBX3_20139965_ChIP-Seq_MESCs_Mouse2.22099985
14GATA1_26923725_Chip-Seq_HPCs_Mouse1.98207181
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.96683013
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95427922
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89846389
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89109491
19DROSHA_22980978_ChIP-Seq_HELA_Human1.88535909
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.81999234
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81713767
22STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.81585383
23GBX2_23144817_ChIP-Seq_PC3_Human1.81427497
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74455745
25CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66927759
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65446227
27TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62124759
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62124759
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.61539714
30TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58136739
31TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55380173
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55283506
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51595293
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.50871137
35CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.48613866
36AHR_22903824_ChIP-Seq_MCF-7_Human1.47540325
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.46986535
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44233960
39IGF1R_20145208_ChIP-Seq_DFB_Human1.41182818
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.40840511
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39726388
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35354420
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35354420
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34231239
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33101101
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32205716
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31189668
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.29792578
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27507472
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.26876199
51* TP53_16413492_ChIP-PET_HCT116_Human1.23090206
52LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21560993
53RUNX2_22187159_ChIP-Seq_PCA_Human1.20962373
54PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20865331
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19613147
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.19531694
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16537232
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14371881
59SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13625341
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13212801
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.13040287
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12853172
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12550415
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12451737
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.12366925
66MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11615751
67ERA_21632823_ChIP-Seq_H3396_Human1.11551002
68SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11523167
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11019767
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10625816
71NANOG_20526341_ChIP-Seq_ESCs_Human1.07812887
72OCT4_20526341_ChIP-Seq_ESCs_Human1.07756323
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07022632
74STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06562552
75STAT3_23295773_ChIP-Seq_U87_Human1.04496432
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02752163
77AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02685257
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02375696
79SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02302680
80KDM2B_26808549_Chip-Seq_REH_Human1.01496625
81ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99927196
82SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97066236
83LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96357241
84RNF2_27304074_Chip-Seq_ESCs_Mouse0.94016754
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92342562
86TAF15_26573619_Chip-Seq_HEK293_Human0.92318274
87FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90111698
88ZNF274_21170338_ChIP-Seq_K562_Hela0.89798663
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89492714
90TAF2_19829295_ChIP-Seq_ESCs_Human0.89151849
91PRDM14_20953172_ChIP-Seq_ESCs_Human0.86989709
92SOX2_21211035_ChIP-Seq_LN229_Human0.86896144
93RAC3_21632823_ChIP-Seq_H3396_Human0.86655302
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84593643
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84294401
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83994815
97* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83939364
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83470614
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83367307
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.82514346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.77573715
2MP0003136_yellow_coat_color4.37562903
3MP0005410_abnormal_fertilization4.31033124
4MP0004145_abnormal_muscle_electrophysio3.61346848
5MP0005503_abnormal_tendon_morphology3.32802372
6MP0005171_absent_coat_pigmentation3.05393438
7MP0004147_increased_porphyrin_level3.03940471
8MP0002277_abnormal_respiratory_mucosa2.73844183
9MP0001661_extended_life_span2.66201219
10MP0004130_abnormal_muscle_cell2.62994248
11MP0006292_abnormal_olfactory_placode2.62692837
12MP0005083_abnormal_biliary_tract2.47495318
13MP0006035_abnormal_mitochondrial_morpho2.46271876
14MP0002638_abnormal_pupillary_reflex2.42898010
15MP0002938_white_spotting2.40042443
16MP0000372_irregular_coat_pigmentation2.35015565
17MP0003878_abnormal_ear_physiology2.18688225
18MP0005377_hearing/vestibular/ear_phenot2.18688225
19MP0003436_decreased_susceptibility_to2.09618946
20MP0003195_calcinosis2.04983644
21MP0000462_abnormal_digestive_system1.91091867
22MP0000579_abnormal_nail_morphology1.82972242
23MP0005084_abnormal_gallbladder_morpholo1.70778780
24MP0004185_abnormal_adipocyte_glucose1.69443701
25MP0002822_catalepsy1.61179271
26MP0005423_abnormal_somatic_nervous1.59722019
27MP0009046_muscle_twitch1.59484160
28MP0000534_abnormal_ureter_morphology1.55503278
29MP0002971_abnormal_brown_adipose1.49160063
30MP0004133_heterotaxia1.43251501
31MP0009745_abnormal_behavioral_response1.38555319
32MP0003137_abnormal_impulse_conducting1.30440477
33MP0004858_abnormal_nervous_system1.27979189
34MP0003635_abnormal_synaptic_transmissio1.25329348
35MP0005174_abnormal_tail_pigmentation1.22571803
36MP0009250_abnormal_appendicular_skeleto1.13086677
37MP0002837_dystrophic_cardiac_calcinosis1.12513262
38MP0000639_abnormal_adrenal_gland1.12386897
39MP0002108_abnormal_muscle_morphology1.12038797
40MP0002148_abnormal_hypersensitivity_rea1.11888932
41MP0002102_abnormal_ear_morphology1.10709567
42MP0002876_abnormal_thyroid_physiology1.10074445
43MP0001664_abnormal_digestion1.09673390
44MP0002184_abnormal_innervation1.07308432
45MP0001486_abnormal_startle_reflex1.07270752
46MP0009764_decreased_sensitivity_to1.05286758
47MP0001501_abnormal_sleep_pattern1.04316931
48MP0009333_abnormal_splenocyte_physiolog1.03224072
49MP0004215_abnormal_myocardial_fiber0.99420434
50MP0001348_abnormal_lacrimal_gland0.98899621
51MP0002933_joint_inflammation0.98045998
52MP0001440_abnormal_grooming_behavior0.97096640
53MP0000358_abnormal_cell_content/0.97035696
54MP0003698_abnormal_male_reproductive0.95602042
55MP0003880_abnormal_central_pattern0.90985924
56MP0004142_abnormal_muscle_tone0.89387686
57MP0002089_abnormal_postnatal_growth/wei0.88867774
58MP0004957_abnormal_blastocyst_morpholog0.88363899
59MP0002557_abnormal_social/conspecific_i0.86129786
60MP0005551_abnormal_eye_electrophysiolog0.85458055
61MP0002272_abnormal_nervous_system0.84668650
62MP0006276_abnormal_autonomic_nervous0.82627037
63MP0000751_myopathy0.81860781
64MP0001243_abnormal_dermal_layer0.80681476
65MP0001970_abnormal_pain_threshold0.79408757
66MP0002064_seizures0.79339065
67MP0000955_abnormal_spinal_cord0.78677592
68MP0000026_abnormal_inner_ear0.78674813
69MP0006072_abnormal_retinal_apoptosis0.77972526
70MP0005332_abnormal_amino_acid0.77590494
71MP0001533_abnormal_skeleton_physiology0.77549592
72MP0001727_abnormal_embryo_implantation0.77372747
73MP0002572_abnormal_emotion/affect_behav0.75978360
74MP0002736_abnormal_nociception_after0.74287897
75MP0002063_abnormal_learning/memory/cond0.72509772
76MP0003718_maternal_effect0.72250004
77MP0002095_abnormal_skin_pigmentation0.68760707
78MP0003879_abnormal_hair_cell0.68378938
79MP0005000_abnormal_immune_tolerance0.67933429
80MP0001790_abnormal_immune_system0.67653554
81MP0005387_immune_system_phenotype0.67653554
82MP0002067_abnormal_sensory_capabilities0.67346359
83MP0001963_abnormal_hearing_physiology0.65828945
84MP0003959_abnormal_lean_body0.64873165
85MP0008995_early_reproductive_senescence0.64582534
86MP0005390_skeleton_phenotype0.63687299
87MP0005647_abnormal_sex_gland0.63021906
88MP0002234_abnormal_pharynx_morphology0.62548576
89MP0005253_abnormal_eye_physiology0.62443459
90MP0002752_abnormal_somatic_nervous0.62124012
91MP0000631_abnormal_neuroendocrine_gland0.60909212
92MP0001485_abnormal_pinna_reflex0.59851986
93MP0003119_abnormal_digestive_system0.59597322
94MP0002932_abnormal_joint_morphology0.58318997
95MP0002733_abnormal_thermal_nociception0.57749858
96MP0002735_abnormal_chemical_nociception0.57221342
97MP0002873_normal_phenotype0.56931716
98MP0002169_no_abnormal_phenotype0.56782505
99MP0001905_abnormal_dopamine_level0.54531373
100MP0004859_abnormal_synaptic_plasticity0.53260820

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)7.75625503
2Premature ovarian failure (HP:0008209)5.90928045
3Delusions (HP:0000746)5.20561173
4Genetic anticipation (HP:0003743)4.98464871
5Personality changes (HP:0000751)4.80283325
6Concave nail (HP:0001598)4.77021253
7Agitation (HP:0000713)4.57116581
8Unsteady gait (HP:0002317)4.18408937
9Absent phalangeal crease (HP:0006109)4.08509151
10Secondary amenorrhea (HP:0000869)3.92680217
11Progressive cerebellar ataxia (HP:0002073)3.90884261
12Prolonged neonatal jaundice (HP:0006579)3.82835549
13Oral leukoplakia (HP:0002745)3.81454925
14Aplasia of the musculature (HP:0100854)3.54965678
15CNS hypomyelination (HP:0003429)3.53343559
16Abnormal finger flexion creases (HP:0006143)3.52816042
17IgM deficiency (HP:0002850)3.40857663
18Truncal obesity (HP:0001956)3.33814281
19Postnatal microcephaly (HP:0005484)3.28444573
20Hypercortisolism (HP:0001578)3.23111224
21Small epiphyses (HP:0010585)3.18017222
22Short femoral neck (HP:0100864)3.15567658
23Hyperventilation (HP:0002883)3.11957687
24Facial diplegia (HP:0001349)3.11839653
25Increased corneal curvature (HP:0100692)2.93603611
26Keratoconus (HP:0000563)2.93603611
27Reticulocytosis (HP:0001923)2.92636920
28Delayed epiphyseal ossification (HP:0002663)2.89313324
29Pendular nystagmus (HP:0012043)2.89097892
30Striae distensae (HP:0001065)2.86991729
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.83884574
32Aplastic anemia (HP:0001915)2.83193665
33Premature graying of hair (HP:0002216)2.77129493
34Sudden death (HP:0001699)2.70426780
35Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.69250901
36Ileus (HP:0002595)2.67624464
37Irregular epiphyses (HP:0010582)2.53118433
38Status epilepticus (HP:0002133)2.52560024
39Polyphagia (HP:0002591)2.45424319
40Ulnar deviation of the wrist (HP:0003049)2.44488878
41Alveolar cell carcinoma (HP:0006519)2.44227956
42Abnormality of lateral ventricle (HP:0030047)2.40916007
43Large for gestational age (HP:0001520)2.37820882
44Central scotoma (HP:0000603)2.37817106
45Testicular atrophy (HP:0000029)2.37187616
46Bony spicule pigmentary retinopathy (HP:0007737)2.34565460
47Severe muscular hypotonia (HP:0006829)2.30069945
48Adrenal overactivity (HP:0002717)2.28983234
49Decreased central vision (HP:0007663)2.26707577
50Pterygium (HP:0001059)2.26680154
51Rough bone trabeculation (HP:0100670)2.23799450
52Abnormal eating behavior (HP:0100738)2.22959042
53Abnormality of cochlea (HP:0000375)2.21979883
54Scotoma (HP:0000575)2.19190869
55Abnormal number of incisors (HP:0011064)2.19040143
56Restlessness (HP:0000711)2.17176941
57Asplenia (HP:0001746)2.16730493
58Renal tubular acidosis (HP:0001947)2.16475734
59Impaired proprioception (HP:0010831)2.15573508
60Osteoarthritis (HP:0002758)2.10673117
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10030988
62Morphological abnormality of the inner ear (HP:0011390)2.07074458
63Neoplasm of the tracheobronchial system (HP:0100552)2.05528542
64Aplasia/hypoplasia of the femur (HP:0005613)2.02703693
65Aplasia/Hypoplasia of the spleen (HP:0010451)2.02049058
66Patellar aplasia (HP:0006443)2.01456887
67Absence seizures (HP:0002121)2.01238581
68Abnormality of reticulocytes (HP:0004312)2.00634136
69Hypoplasia of the fovea (HP:0007750)2.00435872
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.00435872
71Arthropathy (HP:0003040)1.99678397
72Areflexia of lower limbs (HP:0002522)1.96391064
73Diplopia (HP:0000651)1.92888666
74Abnormality of binocular vision (HP:0011514)1.92888666
75Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.92431843
76Aseptic necrosis (HP:0010885)1.91809545
77Heterochromia iridis (HP:0001100)1.88536493
78Narrow nasal bridge (HP:0000446)1.88517141
79Attenuation of retinal blood vessels (HP:0007843)1.87995597
80Aplasia/Hypoplasia of the patella (HP:0006498)1.85551962
81Severe visual impairment (HP:0001141)1.83903092
82Anxiety (HP:0000739)1.79806001
83Renal tubular dysfunction (HP:0000124)1.79386097
84Memory impairment (HP:0002354)1.75845746
85Limited elbow extension (HP:0001377)1.75705601
86Abnormality of the vertebral endplates (HP:0005106)1.75506416
87Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74377279
88Abnormal trabecular bone morphology (HP:0100671)1.74304207
89Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.74134545
90Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73459392
91Retrobulbar optic neuritis (HP:0100654)1.73263013
92Optic neuritis (HP:0100653)1.73263013
93Hypoplasia of the ulna (HP:0003022)1.72975839
94Coronal craniosynostosis (HP:0004440)1.72363853
95Abnormality of the anterior chamber (HP:0000593)1.72007386
96Short 5th finger (HP:0009237)1.71295196
97Poor speech (HP:0002465)1.70357696
98CNS demyelination (HP:0007305)1.67294644
99Encephalitis (HP:0002383)1.67164371
100Hypoplastic ischia (HP:0003175)1.66924957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.08828464
2PRKCI3.94900379
3MAP4K12.57440143
4PDPK12.05324071
5RIPK114.7801936
6PRKCG1.78574728
7DAPK31.66025272
8PASK1.63716793
9MAPKAPK31.50700568
10PRKCE1.41563289
11YES11.29334935
12NEK11.18600179
13NTRK21.12579284
14STK38L1.04105279
15PRKCZ1.00585374
16TRIB30.97454234
17FGR0.89395100
18EIF2AK30.84339068
19INSRR0.83001040
20PRKCD0.80431092
21FLT30.79547577
22MAP4K20.79450806
23FRK0.74080264
24STK240.74057023
25EPHB10.72430318
26ADRBK20.64373807
27PLK40.60203415
28MAP3K120.59957646
29CSK0.53657118
30MTOR0.52878070
31MARK10.46513353
32STK380.43160901
33PRKCB0.42460867
34PTK2B0.41768867
35FYN0.40457906
36MAP2K60.40007356
37MUSK0.35869431
38TIE10.34785973
39PTK20.33972721
40MAPK100.32775442
41MET0.32459350
42PRKCQ0.32282568
43SRC0.31913894
44DYRK30.31701688
45TNIK0.31626584
46DAPK10.31132555
47STK40.28297276
48GRK10.28255286
49SYK0.26539064
50OBSCN0.26249261
51NTRK10.25244929
52WNK40.25077540
53LCK0.24001773
54CDK150.23909929
55PKN10.23195988
56MAPK130.23072865
57TLK10.22747482
58CAMKK10.22350560
59CDK180.20951501
60CDK11A0.18013484
61CSNK2A10.16506906
62RPS6KB20.16431315
63MAP3K40.16305103
64DDR20.16072116
65CDK140.13796850
66PRKCA0.12783086
67ERBB40.12524749
68FGFR10.12310665
69MAP2K70.11915153
70PRKAA10.11872268
71STK30.11809988
72LYN0.11456235
73CSNK2A20.11052520
74PAK40.10587210
75BMPR1B0.10267475
76CSNK1A10.10250528
77ZAK0.10114480
78WNK30.10112943
79MAPK150.09947857
80INSR0.09606242
81ADRBK10.08993233
82TESK20.08932129
83IKBKB0.08914501
84RPS6KB10.08413495
85CAMK2A0.07822140
86DYRK20.07232328
87ILK0.06881842
88PTK60.05721846
89CLK10.04984969
90PHKG10.04695704
91PHKG20.04695704
92AKT10.03827967
93PLK10.03735052
94PRKD10.03586633
95RPS6KA30.03333664
96EGFR0.03208784
97KDR0.02758749
98PRKACA0.01734066
99GRK70.01274526
100STK390.00971886

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003505.83011957
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001304.44438972
3Sulfur relay system_Homo sapiens_hsa041224.07490362
4Lysine degradation_Homo sapiens_hsa003103.55213713
5ErbB signaling pathway_Homo sapiens_hsa040123.33997414
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71219238
7Olfactory transduction_Homo sapiens_hsa047402.59412729
8Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.40518074
9Graft-versus-host disease_Homo sapiens_hsa053322.04708937
10mTOR signaling pathway_Homo sapiens_hsa041502.02789117
11Acute myeloid leukemia_Homo sapiens_hsa052212.01879036
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.89105277
13Fatty acid metabolism_Homo sapiens_hsa012121.80674768
14RNA degradation_Homo sapiens_hsa030181.78706701
15Regulation of autophagy_Homo sapiens_hsa041401.67630440
16Butanoate metabolism_Homo sapiens_hsa006501.63803772
17TGF-beta signaling pathway_Homo sapiens_hsa043501.61805505
18Choline metabolism in cancer_Homo sapiens_hsa052311.56194671
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.55277016
20Tight junction_Homo sapiens_hsa045301.54329539
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48934009
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.48415775
23Tryptophan metabolism_Homo sapiens_hsa003801.45421896
24Longevity regulating pathway - mammal_Homo sapiens_hsa042111.39509401
25Fatty acid degradation_Homo sapiens_hsa000711.35239863
26Ribosome_Homo sapiens_hsa030101.26287005
27Dorso-ventral axis formation_Homo sapiens_hsa043201.23715807
28Fat digestion and absorption_Homo sapiens_hsa049751.22655732
29HIF-1 signaling pathway_Homo sapiens_hsa040661.22164383
30Taste transduction_Homo sapiens_hsa047421.19597119
31T cell receptor signaling pathway_Homo sapiens_hsa046601.18285355
32Insulin resistance_Homo sapiens_hsa049311.17619779
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14367725
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08797430
35Nicotine addiction_Homo sapiens_hsa050331.08135786
36Cardiac muscle contraction_Homo sapiens_hsa042601.06853188
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04241505
38Morphine addiction_Homo sapiens_hsa050321.04216057
39Antigen processing and presentation_Homo sapiens_hsa046121.01953756
40Axon guidance_Homo sapiens_hsa043601.01732536
41Pentose phosphate pathway_Homo sapiens_hsa000300.96227056
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96075375
43AMPK signaling pathway_Homo sapiens_hsa041520.91798217
44Phototransduction_Homo sapiens_hsa047440.88948615
45Linoleic acid metabolism_Homo sapiens_hsa005910.88014682
46Protein digestion and absorption_Homo sapiens_hsa049740.81215083
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81169472
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79711090
49Glycerolipid metabolism_Homo sapiens_hsa005610.77796059
50Glutathione metabolism_Homo sapiens_hsa004800.77231562
51Gastric acid secretion_Homo sapiens_hsa049710.74594681
52Peroxisome_Homo sapiens_hsa041460.68371908
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66492726
54Mineral absorption_Homo sapiens_hsa049780.65016558
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63072021
56beta-Alanine metabolism_Homo sapiens_hsa004100.60616257
57Salivary secretion_Homo sapiens_hsa049700.56490279
58PPAR signaling pathway_Homo sapiens_hsa033200.56141568
59Bile secretion_Homo sapiens_hsa049760.55498171
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54986483
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54624617
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50783623
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49974457
64Pancreatic secretion_Homo sapiens_hsa049720.49860935
65Insulin signaling pathway_Homo sapiens_hsa049100.48590590
66Insulin secretion_Homo sapiens_hsa049110.47869096
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47757786
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47453959
69Complement and coagulation cascades_Homo sapiens_hsa046100.45906973
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45898009
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45662189
72Chemical carcinogenesis_Homo sapiens_hsa052040.45256976
73RNA transport_Homo sapiens_hsa030130.42708835
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40633522
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40569618
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.40563657
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39918599
78Serotonergic synapse_Homo sapiens_hsa047260.37250740
79Circadian entrainment_Homo sapiens_hsa047130.35806294
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.33637075
81Glutamatergic synapse_Homo sapiens_hsa047240.33470794
82TNF signaling pathway_Homo sapiens_hsa046680.32282038
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31598653
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31447831
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.31243084
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30525777
87Calcium signaling pathway_Homo sapiens_hsa040200.30466575
88Malaria_Homo sapiens_hsa051440.28784858
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27328679
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25647699
91Nitrogen metabolism_Homo sapiens_hsa009100.25022804
92Retinol metabolism_Homo sapiens_hsa008300.23524846
93GABAergic synapse_Homo sapiens_hsa047270.23192126
94Proteoglycans in cancer_Homo sapiens_hsa052050.22024928
95Fatty acid biosynthesis_Homo sapiens_hsa000610.21509243
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.18871756
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18137251
98Autoimmune thyroid disease_Homo sapiens_hsa053200.17070096
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.16547055
100cAMP signaling pathway_Homo sapiens_hsa040240.14580535

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