ANOS2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.92049763
2behavioral response to nicotine (GO:0035095)4.69901150
3response to pheromone (GO:0019236)4.66779715
4fucose catabolic process (GO:0019317)4.60016823
5L-fucose metabolic process (GO:0042354)4.60016823
6L-fucose catabolic process (GO:0042355)4.60016823
7nucleobase catabolic process (GO:0046113)4.42837822
8ubiquinone biosynthetic process (GO:0006744)3.88216813
9DNA deamination (GO:0045006)3.87061609
10cullin deneddylation (GO:0010388)3.78004168
11ubiquinone metabolic process (GO:0006743)3.76956742
12sequestering of actin monomers (GO:0042989)3.72000473
13platelet dense granule organization (GO:0060155)3.69312645
14neuron cell-cell adhesion (GO:0007158)3.63936942
15negative regulation of mast cell activation (GO:0033004)3.63601386
16presynaptic membrane assembly (GO:0097105)3.55010028
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.51291442
18organelle disassembly (GO:1903008)3.50706951
19DNA double-strand break processing (GO:0000729)3.49235855
20epithelial cilium movement (GO:0003351)3.45873885
21negative regulation of telomere maintenance (GO:0032205)3.44346290
22negative regulation of transcription regulatory region DNA binding (GO:2000678)3.32889505
23presynaptic membrane organization (GO:0097090)3.28851070
24protein deneddylation (GO:0000338)3.25841126
25regulation of posttranscriptional gene silencing (GO:0060147)3.22550664
26regulation of gene silencing by miRNA (GO:0060964)3.22550664
27regulation of gene silencing by RNA (GO:0060966)3.22550664
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17215082
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.17215082
30quinone biosynthetic process (GO:1901663)3.15276963
31regulation of sarcomere organization (GO:0060297)3.11413741
32C4-dicarboxylate transport (GO:0015740)3.10215313
33photoreceptor cell maintenance (GO:0045494)3.09735496
34postsynaptic membrane organization (GO:0001941)3.06097213
35ribonucleoprotein complex disassembly (GO:0032988)3.05055311
36regulation of hexokinase activity (GO:1903299)3.04087612
37regulation of glucokinase activity (GO:0033131)3.04087612
38regulation of action potential (GO:0098900)2.99209350
39sulfation (GO:0051923)2.99063925
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97354953
41negative regulation of cytosolic calcium ion concentration (GO:0051481)2.95899248
42vocalization behavior (GO:0071625)2.94066167
43neural tube formation (GO:0001841)2.93485240
44gamma-aminobutyric acid transport (GO:0015812)2.92049103
45water-soluble vitamin biosynthetic process (GO:0042364)2.91877146
46negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91005671
47protein polyglutamylation (GO:0018095)2.84281171
48neuronal action potential (GO:0019228)2.83812749
49forebrain neuron differentiation (GO:0021879)2.83024726
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82283492
51positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.79707581
52histone H2A acetylation (GO:0043968)2.79082694
53regulation of cilium movement (GO:0003352)2.77764306
54indolalkylamine metabolic process (GO:0006586)2.76260766
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.74714175
56regulation of translation, ncRNA-mediated (GO:0045974)2.74714175
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74714175
58negative regulation of DNA-dependent DNA replication (GO:2000104)2.73021123
59somite development (GO:0061053)2.71352603
60protein localization to cilium (GO:0061512)2.71059928
61respiratory chain complex IV assembly (GO:0008535)2.70162789
62neuronal action potential propagation (GO:0019227)2.69935535
63cilium movement (GO:0003341)2.69172049
64calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.69034957
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67441368
66nonmotile primary cilium assembly (GO:0035058)2.66179893
67protein neddylation (GO:0045116)2.63427534
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62637136
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62234021
70protein-cofactor linkage (GO:0018065)2.61573338
71behavioral response to ethanol (GO:0048149)2.61281228
72somite rostral/caudal axis specification (GO:0032525)2.61201610
73glycerophospholipid catabolic process (GO:0046475)2.60461129
74tryptophan metabolic process (GO:0006568)2.59575158
75kidney morphogenesis (GO:0060993)2.57806849
76positive regulation of mitochondrial fission (GO:0090141)2.57497914
77regulation of telomere maintenance (GO:0032204)2.57026746
78intraciliary transport (GO:0042073)2.56956814
79protein complex biogenesis (GO:0070271)2.56148095
80regulation of hippo signaling (GO:0035330)2.54617522
81RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54530512
82tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54530512
83fucosylation (GO:0036065)2.54112678
84tryptophan catabolic process (GO:0006569)2.53354544
85indole-containing compound catabolic process (GO:0042436)2.53354544
86indolalkylamine catabolic process (GO:0046218)2.53354544
87DNA demethylation (GO:0080111)2.53313516
88regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.52402078
89synapse assembly (GO:0007416)2.50151065
90negative regulation of heart rate (GO:0010459)2.49965404
91regulation of helicase activity (GO:0051095)2.48848582
92cornea development in camera-type eye (GO:0061303)2.47145049
93regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.46084975
94regulation of feeding behavior (GO:0060259)2.45307647
95cilium morphogenesis (GO:0060271)2.45204427
96mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.44290752
97mitochondrial respiratory chain complex I assembly (GO:0032981)2.44290752
98NADH dehydrogenase complex assembly (GO:0010257)2.44290752
99dopamine transport (GO:0015872)2.44229903
100alanine transport (GO:0032328)2.43875459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.38665212
2IGF1R_20145208_ChIP-Seq_DFB_Human4.30741085
3VDR_22108803_ChIP-Seq_LS180_Human3.51441853
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30942039
5EZH2_22144423_ChIP-Seq_EOC_Human2.71662418
6GBX2_23144817_ChIP-Seq_PC3_Human2.70848759
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50024574
8FUS_26573619_Chip-Seq_HEK293_Human2.46702492
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33066533
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31929974
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31448635
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30904332
13EWS_26573619_Chip-Seq_HEK293_Human2.28899390
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24993695
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.23319570
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20931547
17TAF15_26573619_Chip-Seq_HEK293_Human2.16837105
18P300_19829295_ChIP-Seq_ESCs_Human2.15875806
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08920016
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.98012316
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.97766053
22IRF1_19129219_ChIP-ChIP_H3396_Human1.89936901
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88463443
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85322502
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79413477
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75460180
27ER_23166858_ChIP-Seq_MCF-7_Human1.73127326
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72459833
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.71265837
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.68168569
31CBP_20019798_ChIP-Seq_JUKART_Human1.57076014
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57076014
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52631437
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52154787
35MYC_18940864_ChIP-ChIP_HL60_Human1.51734123
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.49887400
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49149857
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.47644779
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47285511
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47020515
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47020515
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46576300
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45617876
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45122077
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42614220
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41260466
47TP53_22573176_ChIP-Seq_HFKS_Human1.39121742
48BCAT_22108803_ChIP-Seq_LS180_Human1.38933074
49SMAD4_21799915_ChIP-Seq_A2780_Human1.38259210
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37440131
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37108788
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35581678
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.34753114
54RNF2_27304074_Chip-Seq_NSC_Mouse1.33228569
55STAT3_23295773_ChIP-Seq_U87_Human1.32185378
56ELK1_19687146_ChIP-ChIP_HELA_Human1.32115942
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32061387
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31549726
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31356526
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29612638
61NANOG_19829295_ChIP-Seq_ESCs_Human1.29153666
62SOX2_19829295_ChIP-Seq_ESCs_Human1.29153666
63AR_25329375_ChIP-Seq_VCAP_Human1.28020254
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.27664222
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26834738
66REST_21632747_ChIP-Seq_MESCs_Mouse1.25107590
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24354641
68TCF4_23295773_ChIP-Seq_U87_Human1.21913577
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14409106
70VDR_23849224_ChIP-Seq_CD4+_Human1.14343746
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12016065
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.10999139
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10871275
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10397263
75RUNX2_22187159_ChIP-Seq_PCA_Human1.09773901
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08923528
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.07985259
78REST_18959480_ChIP-ChIP_MESCs_Mouse1.07540368
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07066714
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05006763
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.05006763
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.04198839
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.02550632
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.01818039
85NCOR_22424771_ChIP-Seq_293T_Human1.01055384
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00876473
87TCF4_22108803_ChIP-Seq_LS180_Human1.00407657
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00338099
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00258945
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97721984
91NANOG_18555785_Chip-Seq_ESCs_Mouse0.96798645
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95269367
93AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95088073
94SOX2_16153702_ChIP-ChIP_HESCs_Human0.94874132
95FLI1_21867929_ChIP-Seq_TH2_Mouse0.94455570
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93366172
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93117573
98MYC_19829295_ChIP-Seq_ESCs_Human0.92778094
99P53_22387025_ChIP-Seq_ESCs_Mouse0.92650544
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.91262114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.43619809
2MP0002102_abnormal_ear_morphology2.99156981
3MP0001968_abnormal_touch/_nociception2.53662773
4MP0004133_heterotaxia2.43036554
5MP0008789_abnormal_olfactory_epithelium2.34952601
6MP0006072_abnormal_retinal_apoptosis2.29403797
7MP0006276_abnormal_autonomic_nervous2.28103792
8MP0001529_abnormal_vocalization2.26980417
9MP0006292_abnormal_olfactory_placode2.23454854
10MP0002736_abnormal_nociception_after2.20810983
11MP0002653_abnormal_ependyma_morphology2.20690767
12MP0003787_abnormal_imprinting2.19938048
13MP0005499_abnormal_olfactory_system2.18725045
14MP0005394_taste/olfaction_phenotype2.18725045
15MP0003195_calcinosis2.11822190
16MP0008877_abnormal_DNA_methylation1.95844941
17MP0002254_reproductive_system_inflammat1.94542927
18MP0001984_abnormal_olfaction1.91138601
19MP0003890_abnormal_embryonic-extraembry1.88505679
20MP0005253_abnormal_eye_physiology1.87297306
21MP0005551_abnormal_eye_electrophysiolog1.81920288
22MP0009046_muscle_twitch1.79443280
23MP0005645_abnormal_hypothalamus_physiol1.75927392
24MP0001485_abnormal_pinna_reflex1.74247542
25MP0000631_abnormal_neuroendocrine_gland1.73808350
26MP0002837_dystrophic_cardiac_calcinosis1.71741607
27MP0003011_delayed_dark_adaptation1.71456360
28MP0002751_abnormal_autonomic_nervous1.67695374
29MP0009745_abnormal_behavioral_response1.66586353
30MP0003136_yellow_coat_color1.63569767
31MP0000372_irregular_coat_pigmentation1.59787762
32MP0002938_white_spotting1.54636195
33MP0001486_abnormal_startle_reflex1.51417995
34MP0001986_abnormal_taste_sensitivity1.47940842
35MP0005075_abnormal_melanosome_morpholog1.44513415
36MP0004270_analgesia1.43797185
37MP0003119_abnormal_digestive_system1.43094057
38MP0008872_abnormal_physiological_respon1.41787751
39MP0005084_abnormal_gallbladder_morpholo1.39521710
40MP0000566_synostosis1.37016768
41MP0003646_muscle_fatigue1.36845500
42MP0004885_abnormal_endolymph1.35258861
43MP0002735_abnormal_chemical_nociception1.32967649
44MP0002272_abnormal_nervous_system1.32677651
45MP0005646_abnormal_pituitary_gland1.32666808
46MP0000049_abnormal_middle_ear1.32052056
47MP0001764_abnormal_homeostasis1.31640294
48MP0003718_maternal_effect1.31553599
49MP0003567_abnormal_fetal_cardiomyocyte1.31187347
50MP0002733_abnormal_thermal_nociception1.30667658
51MP0001501_abnormal_sleep_pattern1.27575782
52MP0002557_abnormal_social/conspecific_i1.24578736
53MP0002163_abnormal_gland_morphology1.23601921
54MP0002277_abnormal_respiratory_mucosa1.23511395
55MP0005423_abnormal_somatic_nervous1.22887537
56MP0003121_genomic_imprinting1.21476662
57MP0002064_seizures1.21298674
58MP0000569_abnormal_digit_pigmentation1.20709720
59MP0002572_abnormal_emotion/affect_behav1.15718141
60MP0004043_abnormal_pH_regulation1.14673049
61MP0003635_abnormal_synaptic_transmissio1.14656189
62MP0001293_anophthalmia1.11973440
63MP0004142_abnormal_muscle_tone1.11077919
64MP0001970_abnormal_pain_threshold1.10723384
65MP0000647_abnormal_sebaceous_gland1.08183661
66MP0001919_abnormal_reproductive_system1.05252581
67MP0002138_abnormal_hepatobiliary_system1.03101475
68MP0003693_abnormal_embryo_hatching1.02511375
69MP0006035_abnormal_mitochondrial_morpho1.00630154
70MP0002734_abnormal_mechanical_nocicepti1.00374099
71MP0001188_hyperpigmentation1.00101518
72MP0003937_abnormal_limbs/digits/tail_de0.98646024
73MP0005187_abnormal_penis_morphology0.97736051
74MP0002067_abnormal_sensory_capabilities0.97720461
75MP0005379_endocrine/exocrine_gland_phen0.97633039
76MP0005410_abnormal_fertilization0.97266280
77MP0009697_abnormal_copulation0.96892105
78MP0008875_abnormal_xenobiotic_pharmacok0.95294980
79MP0002233_abnormal_nose_morphology0.93331651
80MP0008058_abnormal_DNA_repair0.92948846
81MP0005391_vision/eye_phenotype0.92733984
82MP0002184_abnormal_innervation0.92639921
83MP0001905_abnormal_dopamine_level0.92142156
84MP0002752_abnormal_somatic_nervous0.91268407
85MP0002090_abnormal_vision0.91242487
86MP0002063_abnormal_learning/memory/cond0.87989311
87MP0002638_abnormal_pupillary_reflex0.87394347
88MP0002822_catalepsy0.86781235
89MP0003938_abnormal_ear_development0.85745485
90MP0003698_abnormal_male_reproductive0.85286706
91MP0000427_abnormal_hair_cycle0.84844393
92MP0000383_abnormal_hair_follicle0.82052035
93MP0002876_abnormal_thyroid_physiology0.81365857
94MP0001270_distended_abdomen0.81276975
95MP0005195_abnormal_posterior_eye0.79841715
96MP0004215_abnormal_myocardial_fiber0.79200110
97MP0000778_abnormal_nervous_system0.75458016
98MP0003283_abnormal_digestive_organ0.75354992
99MP0003122_maternal_imprinting0.75126719
100MP0000026_abnormal_inner_ear0.74588101

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.75700234
2Pancreatic fibrosis (HP:0100732)3.50235450
3Intestinal atresia (HP:0011100)3.40614699
4Abnormality of midbrain morphology (HP:0002418)3.39221251
5Molar tooth sign on MRI (HP:0002419)3.39221251
6True hermaphroditism (HP:0010459)3.31072624
7Nephronophthisis (HP:0000090)3.08931970
8Abolished electroretinogram (ERG) (HP:0000550)3.01909292
9Hyperventilation (HP:0002883)2.90827546
10Abnormality of the labia minora (HP:0012880)2.89287468
11Abnormality of the renal medulla (HP:0100957)2.79428401
12Chronic hepatic failure (HP:0100626)2.74047382
13Medial flaring of the eyebrow (HP:0010747)2.66306743
14Abnormality of the renal cortex (HP:0011035)2.65826669
15Attenuation of retinal blood vessels (HP:0007843)2.62617575
16Retinal dysplasia (HP:0007973)2.48632921
17Progressive inability to walk (HP:0002505)2.45673594
18Aplasia/hypoplasia of the uterus (HP:0008684)2.43750535
19Inability to walk (HP:0002540)2.42905891
20Pendular nystagmus (HP:0012043)2.42869441
21Thyroid-stimulating hormone excess (HP:0002925)2.42296172
22Type II lissencephaly (HP:0007260)2.41959105
23Renal cortical cysts (HP:0000803)2.40069111
24Colon cancer (HP:0003003)2.38485707
25Decreased circulating renin level (HP:0003351)2.33964154
26Absent speech (HP:0001344)2.31172705
27Cystic liver disease (HP:0006706)2.30312215
28Anencephaly (HP:0002323)2.27980828
29Lissencephaly (HP:0001339)2.26705180
30Sclerocornea (HP:0000647)2.25896277
31Delayed CNS myelination (HP:0002188)2.22990440
32Decreased central vision (HP:0007663)2.20382295
33Increased corneal curvature (HP:0100692)2.19653056
34Keratoconus (HP:0000563)2.19653056
35Bile duct proliferation (HP:0001408)2.18550653
36Abnormal biliary tract physiology (HP:0012439)2.18550653
37Gastrointestinal atresia (HP:0002589)2.16866250
38Hyperglycinemia (HP:0002154)2.13010704
39Congenital primary aphakia (HP:0007707)2.12711343
40Occipital encephalocele (HP:0002085)2.12255832
41Hypomagnesemia (HP:0002917)2.11672911
42Gait imbalance (HP:0002141)2.10516336
43Broad-based gait (HP:0002136)2.10138926
44Congenital stationary night blindness (HP:0007642)2.08103442
45Genital tract atresia (HP:0001827)2.05973753
46Poor suck (HP:0002033)2.02955920
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.01440470
48Vaginal atresia (HP:0000148)2.01242541
49Abnormal ciliary motility (HP:0012262)2.01005740
50Polyuria (HP:0000103)1.99249689
51Postaxial foot polydactyly (HP:0001830)1.99133181
52Nephrogenic diabetes insipidus (HP:0009806)1.98927677
53Lipid accumulation in hepatocytes (HP:0006561)1.96178970
54Carpal bone hypoplasia (HP:0001498)1.95112654
55Adactyly (HP:0009776)1.95007854
56Hyperglycinuria (HP:0003108)1.94800220
57Patellar aplasia (HP:0006443)1.94502292
58Hypothermia (HP:0002045)1.93910468
59Increased hepatocellular lipid droplets (HP:0006565)1.93202603
60Mitochondrial inheritance (HP:0001427)1.90556055
61Renal hypoplasia (HP:0000089)1.90294547
62Abnormality of serine family amino acid metabolism (HP:0010894)1.90227186
63Abnormality of glycine metabolism (HP:0010895)1.90227186
64Neoplasm of the adrenal cortex (HP:0100641)1.89751930
65Abnormal respiratory epithelium morphology (HP:0012253)1.89605776
66Abnormal respiratory motile cilium morphology (HP:0005938)1.89605776
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88568854
68Abnormality of alanine metabolism (HP:0010916)1.88568854
69Hyperalaninemia (HP:0003348)1.88568854
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87318163
71Dandy-Walker malformation (HP:0001305)1.87032622
72Renal salt wasting (HP:0000127)1.86546594
73Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86449769
74Oligodactyly (hands) (HP:0001180)1.85896978
75Acute necrotizing encephalopathy (HP:0006965)1.85215612
76Type 2 muscle fiber atrophy (HP:0003554)1.84791401
77Calf muscle hypertrophy (HP:0008981)1.84696763
78Postaxial hand polydactyly (HP:0001162)1.84693495
79Abnormal rod and cone electroretinograms (HP:0008323)1.84573706
80Drooling (HP:0002307)1.84496450
81Tubulointerstitial nephritis (HP:0001970)1.83340645
82Protruding tongue (HP:0010808)1.82216362
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82129642
84Acute encephalopathy (HP:0006846)1.82042318
85Optic nerve hypoplasia (HP:0000609)1.81005812
86Aplasia/Hypoplasia of the patella (HP:0006498)1.80827521
87Abnormality of the pons (HP:0007361)1.80298839
88Bony spicule pigmentary retinopathy (HP:0007737)1.79548406
89Cerebellar dysplasia (HP:0007033)1.79042697
90Hypoplasia of the uterus (HP:0000013)1.79025884
91Abnormality of macular pigmentation (HP:0008002)1.75550066
92Pachygyria (HP:0001302)1.75320943
93Hypokalemic alkalosis (HP:0001949)1.75169744
94Increased CSF lactate (HP:0002490)1.74575089
95Optic disc pallor (HP:0000543)1.73236655
96Polyphagia (HP:0002591)1.71155925
97Congenital hepatic fibrosis (HP:0002612)1.70958502
98Hypoplasia of the pons (HP:0012110)1.68517374
99Widely spaced teeth (HP:0000687)1.68357394
100Gaze-evoked nystagmus (HP:0000640)1.68146014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.37460275
2MAP4K24.16333235
3ZAK3.82344856
4WNK33.61492988
5BMPR1B3.04175294
6MAP3K42.80231053
7MAP2K72.65682090
8FRK2.42699959
9TLK12.41854790
10TRIM282.31175057
11BCR2.24702754
12ADRBK22.06849744
13PINK11.98391325
14CSNK1G31.81092087
15CSNK1G11.69152115
16CSNK1A1L1.65095264
17CSNK1G21.64568495
18NUAK11.60400098
19VRK11.56570076
20RPS6KA41.54038076
21GRK11.47733040
22DYRK21.45116800
23TNIK1.41217557
24ACVR1B1.40872664
25SRPK11.25711997
26MAPK131.25253763
27CASK1.24956858
28DYRK31.18980427
29PLK21.16397151
30CDK191.12779570
31MKNK21.08670547
32FER1.05153293
33TAF11.04653676
34MKNK11.04318935
35DAPK21.03964162
36WNK41.02714604
37PLK30.98009579
38TGFBR10.97617276
39CDC70.97019128
40PRKCE0.95646472
41OXSR10.94071489
42VRK20.93467853
43TAOK30.91338113
44TIE10.88106470
45IRAK10.83554251
46NLK0.76212537
47STK160.75965593
48CDK80.75522979
49MARK10.74279145
50EPHA30.70928879
51FLT30.70221513
52RPS6KA50.69655995
53MAP2K40.66758912
54FGFR20.66475783
55PRKCG0.64220628
56MAPKAPK50.63527460
57GRK70.63235685
58MINK10.62896118
59PLK10.57629832
60STK38L0.56828673
61MST40.56121110
62MUSK0.55679269
63PLK40.55372809
64TNK20.54904062
65UHMK10.54872738
66CDK30.54844625
67PAK30.53808281
68ADRBK10.53366694
69BCKDK0.52470977
70BRSK20.52224653
71ERBB30.50956772
72BUB10.50420562
73PRKCQ0.48383190
74PASK0.47877811
75CSNK1D0.47480762
76CSNK1A10.47442309
77DYRK1A0.47173755
78KIT0.47076255
79TSSK60.45161587
80CAMK2A0.45006115
81MARK30.42755430
82SIK30.41964060
83PKN10.39352426
84PIK3CA0.37315134
85ERBB40.36947621
86EGFR0.35829513
87OBSCN0.35149527
88ATM0.33792197
89PHKG20.32223008
90PHKG10.32223008
91STK390.30890624
92MATK0.30702840
93KDR0.28842052
94WEE10.28811199
95PRKACA0.28606992
96CAMKK20.28003012
97ATR0.27857673
98PRKACB0.27251667
99CAMK40.27008665
100TEC0.26950116

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.02076856
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72782680
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47343213
4Phototransduction_Homo sapiens_hsa047442.36826154
5RNA polymerase_Homo sapiens_hsa030202.25068542
6Selenocompound metabolism_Homo sapiens_hsa004502.18929413
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.17712126
8Butanoate metabolism_Homo sapiens_hsa006502.09103073
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07035604
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04443934
11Oxidative phosphorylation_Homo sapiens_hsa001902.01549903
12Nicotine addiction_Homo sapiens_hsa050331.97167760
13Basal transcription factors_Homo sapiens_hsa030221.86696082
14Linoleic acid metabolism_Homo sapiens_hsa005911.86205381
15Parkinsons disease_Homo sapiens_hsa050121.83791762
16Propanoate metabolism_Homo sapiens_hsa006401.79572596
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.75846674
18Taste transduction_Homo sapiens_hsa047421.66608819
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.59998255
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57530912
21Mismatch repair_Homo sapiens_hsa034301.54560187
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54078000
23Fanconi anemia pathway_Homo sapiens_hsa034601.50340572
24Nitrogen metabolism_Homo sapiens_hsa009101.49454582
25Ether lipid metabolism_Homo sapiens_hsa005651.49111506
26RNA degradation_Homo sapiens_hsa030181.48614372
27Tryptophan metabolism_Homo sapiens_hsa003801.41491470
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41483212
29Olfactory transduction_Homo sapiens_hsa047401.37961374
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.33801453
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30194736
32Steroid biosynthesis_Homo sapiens_hsa001001.30116918
33GABAergic synapse_Homo sapiens_hsa047271.28362916
34Asthma_Homo sapiens_hsa053101.24676806
35Proteasome_Homo sapiens_hsa030501.23635493
36Morphine addiction_Homo sapiens_hsa050321.20282403
37Peroxisome_Homo sapiens_hsa041461.19492357
38Homologous recombination_Homo sapiens_hsa034401.19148756
39Protein export_Homo sapiens_hsa030601.18660651
40Caffeine metabolism_Homo sapiens_hsa002321.17866855
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.16241022
42Pyruvate metabolism_Homo sapiens_hsa006201.14362061
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10890691
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10791804
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06982479
46Purine metabolism_Homo sapiens_hsa002301.05857830
47Huntingtons disease_Homo sapiens_hsa050161.03432736
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.01810011
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.01486756
50Alzheimers disease_Homo sapiens_hsa050101.01476561
51beta-Alanine metabolism_Homo sapiens_hsa004101.00579030
52Base excision repair_Homo sapiens_hsa034100.97937134
53Circadian entrainment_Homo sapiens_hsa047130.95701404
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94151188
55Nucleotide excision repair_Homo sapiens_hsa034200.92877246
56DNA replication_Homo sapiens_hsa030300.92426231
57Pyrimidine metabolism_Homo sapiens_hsa002400.91471383
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91139794
59Chemical carcinogenesis_Homo sapiens_hsa052040.89621604
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.87772601
61Cardiac muscle contraction_Homo sapiens_hsa042600.86118808
62Systemic lupus erythematosus_Homo sapiens_hsa053220.84084135
63Regulation of autophagy_Homo sapiens_hsa041400.82701332
64Type I diabetes mellitus_Homo sapiens_hsa049400.81119509
65Collecting duct acid secretion_Homo sapiens_hsa049660.81039536
66Arachidonic acid metabolism_Homo sapiens_hsa005900.78109422
67ABC transporters_Homo sapiens_hsa020100.77604363
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76575161
69Retinol metabolism_Homo sapiens_hsa008300.73781439
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72102548
71Serotonergic synapse_Homo sapiens_hsa047260.72047799
72Glutamatergic synapse_Homo sapiens_hsa047240.71322807
73Alcoholism_Homo sapiens_hsa050340.68868031
74Histidine metabolism_Homo sapiens_hsa003400.65805613
75Dopaminergic synapse_Homo sapiens_hsa047280.65416996
76Metabolic pathways_Homo sapiens_hsa011000.64276891
77Spliceosome_Homo sapiens_hsa030400.61160575
78Circadian rhythm_Homo sapiens_hsa047100.60584235
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60461366
80One carbon pool by folate_Homo sapiens_hsa006700.58444299
81Non-homologous end-joining_Homo sapiens_hsa034500.54825594
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54419558
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54236278
84Primary immunodeficiency_Homo sapiens_hsa053400.53597410
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52485233
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50101931
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48776850
88Folate biosynthesis_Homo sapiens_hsa007900.48229214
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48118327
90Insulin secretion_Homo sapiens_hsa049110.47879963
91Graft-versus-host disease_Homo sapiens_hsa053320.47672970
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47183229
93Oocyte meiosis_Homo sapiens_hsa041140.46131633
94Arginine and proline metabolism_Homo sapiens_hsa003300.45859634
95Calcium signaling pathway_Homo sapiens_hsa040200.44937664
96Autoimmune thyroid disease_Homo sapiens_hsa053200.41524262
97Glycerolipid metabolism_Homo sapiens_hsa005610.41339039
98Allograft rejection_Homo sapiens_hsa053300.40936791
99Fatty acid degradation_Homo sapiens_hsa000710.40706629
100Fatty acid elongation_Homo sapiens_hsa000620.38998341

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