ANOS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by miRNA (GO:0060964)5.65327807
2regulation of gene silencing by RNA (GO:0060966)5.65327807
3regulation of posttranscriptional gene silencing (GO:0060147)5.65327807
4paraxial mesoderm development (GO:0048339)5.23653209
5presynaptic membrane assembly (GO:0097105)5.08636637
6pre-miRNA processing (GO:0031054)4.82655105
7L-serine metabolic process (GO:0006563)4.45313336
8positive regulation of SMAD protein import into nucleus (GO:0060391)4.43576633
9regulation of cell fate specification (GO:0042659)4.35419662
10presynaptic membrane organization (GO:0097090)4.26385862
11establishment of integrated proviral latency (GO:0075713)4.19388806
12protein complex localization (GO:0031503)3.92661796
13heterochromatin organization (GO:0070828)3.82953675
14notochord development (GO:0030903)3.77035308
15hyperosmotic salinity response (GO:0042538)3.73643352
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.72303627
17lung-associated mesenchyme development (GO:0060484)3.62550204
18vocalization behavior (GO:0071625)3.53858732
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.42173557
20convergent extension (GO:0060026)3.38508109
21nuclear pore complex assembly (GO:0051292)3.35307733
22regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.32119256
23dorsal/ventral axis specification (GO:0009950)3.31115710
24chromatin remodeling at centromere (GO:0031055)3.30458248
25anterior/posterior axis specification, embryo (GO:0008595)3.29978519
26cellular protein complex localization (GO:0034629)3.29933571
27protein localization to kinetochore (GO:0034501)3.28188411
28IMP biosynthetic process (GO:0006188)3.19854942
29positive regulation of catenin import into nucleus (GO:0035413)3.19576581
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.18062982
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.17368252
32postsynaptic membrane organization (GO:0001941)3.16909275
33generation of neurons (GO:0048699)3.16381527
34negative regulation of cell fate specification (GO:0009996)3.15983120
35IMP metabolic process (GO:0046040)3.15681102
36regulation of helicase activity (GO:0051095)3.14448074
37cell fate commitment involved in formation of primary germ layer (GO:0060795)3.09913365
38CENP-A containing nucleosome assembly (GO:0034080)3.09665554
39regulation of SMAD protein import into nucleus (GO:0060390)3.09209410
40negative regulation of cell fate commitment (GO:0010454)3.07454531
41regulation of cell fate commitment (GO:0010453)3.06368231
42nuclear pore organization (GO:0006999)3.04311618
43cell migration involved in gastrulation (GO:0042074)3.01939068
44lateral sprouting from an epithelium (GO:0060601)2.99309463
45negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.96147500
46negative regulation of translation, ncRNA-mediated (GO:0040033)2.96147500
47regulation of translation, ncRNA-mediated (GO:0045974)2.96147500
48neuron cell-cell adhesion (GO:0007158)2.96146661
49establishment of viral latency (GO:0019043)2.94859202
50histone exchange (GO:0043486)2.87557888
51DNA replication-independent nucleosome organization (GO:0034724)2.85326461
52DNA replication-independent nucleosome assembly (GO:0006336)2.85326461
53atrial cardiac muscle cell action potential (GO:0086014)2.84236898
54regulation of gene silencing (GO:0060968)2.83168328
55negative regulation of gene silencing (GO:0060969)2.82620782
56mitotic metaphase plate congression (GO:0007080)2.80815510
57mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.78573240
58regulation of histone H3-K9 methylation (GO:0051570)2.72296269
59hippo signaling (GO:0035329)2.70825446
60cell surface receptor signaling pathway involved in heart development (GO:0061311)2.70231607
61gap junction assembly (GO:0016264)2.69605492
62negative regulation of mitotic sister chromatid separation (GO:2000816)2.69084726
63negative regulation of sister chromatid segregation (GO:0033046)2.69084726
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.69084726
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69084726
66negative regulation of mitotic sister chromatid segregation (GO:0033048)2.69084726
67establishment of apical/basal cell polarity (GO:0035089)2.67876355
68DNA unwinding involved in DNA replication (GO:0006268)2.67724722
69lysine catabolic process (GO:0006554)2.64613995
70lysine metabolic process (GO:0006553)2.64613995
71regulation of non-canonical Wnt signaling pathway (GO:2000050)2.63932565
72regulation of telomere maintenance via telomerase (GO:0032210)2.63668771
73inner ear receptor cell development (GO:0060119)2.63067001
74negative regulation of chromosome segregation (GO:0051985)2.62787336
75negative regulation of telomerase activity (GO:0051974)2.62033230
76cellular response to cholesterol (GO:0071397)2.61423355
77DNA replication-dependent nucleosome organization (GO:0034723)2.60945132
78DNA replication-dependent nucleosome assembly (GO:0006335)2.60945132
79DNA replication checkpoint (GO:0000076)2.60808236
80regulation of catenin import into nucleus (GO:0035412)2.58739508
81mitotic G2/M transition checkpoint (GO:0044818)2.58186900
82somatic stem cell division (GO:0048103)2.54442162
83mesenchymal to epithelial transition (GO:0060231)2.53808150
84regulation of mitotic spindle checkpoint (GO:1903504)2.53144779
85regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53144779
86outer ear morphogenesis (GO:0042473)2.52518162
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.51929336
88negative regulation of DNA recombination (GO:0045910)2.51510939
89ATP-dependent chromatin remodeling (GO:0043044)2.50965896
90apical protein localization (GO:0045176)2.50903589
91metaphase plate congression (GO:0051310)2.50644434
92regulation of stem cell maintenance (GO:2000036)2.50548276
93dermatan sulfate biosynthetic process (GO:0030208)2.49311481
94regulation of mesoderm development (GO:2000380)2.49055820
95organ growth (GO:0035265)2.49029101
96establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.46078886
97neurotransmitter uptake (GO:0001504)2.45892079
98neural tube closure (GO:0001843)2.45868051
99protein localization to chromosome, centromeric region (GO:0071459)2.44735587
100tube closure (GO:0060606)2.43822128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28098597
2NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.23580732
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.12263301
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.12263301
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.12263301
6POU5F1_16153702_ChIP-ChIP_HESCs_Human2.92452878
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.92172333
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83637103
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.78248064
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51634611
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.48426319
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.35839983
13TCF3_18692474_ChIP-Seq_MEFs_Mouse2.31528614
14SOX2_16153702_ChIP-ChIP_HESCs_Human2.19689738
15NANOG_16153702_ChIP-ChIP_HESCs_Human2.18183847
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08241291
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.08224763
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06068223
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03315514
20TCF3_18692474_ChIP-Seq_MESCs_Mouse2.01506907
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99869818
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89487716
23EZH2_22144423_ChIP-Seq_EOC_Human1.87774020
24AR_21909140_ChIP-Seq_LNCAP_Human1.87618768
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.85147475
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.82316024
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81224491
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79084178
29GBX2_23144817_ChIP-Seq_PC3_Human1.69454141
30POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.69130334
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68773378
32TBX3_20139965_ChIP-Seq_ESCs_Mouse1.66740189
33TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66699728
34TBX3_20139965_ChIP-Seq_MESCs_Mouse1.66293913
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.66101694
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.65264956
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.65264470
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60380282
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57854988
40P300_19829295_ChIP-Seq_ESCs_Human1.57462522
41FUS_26573619_Chip-Seq_HEK293_Human1.52605750
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51994573
43EWS_26573619_Chip-Seq_HEK293_Human1.40893801
44ISL1_27105846_Chip-Seq_CPCs_Mouse1.39481364
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38211441
46TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35865607
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35157531
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34105276
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27905936
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27290085
51NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26578471
52PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25607636
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.24948073
54PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.24064260
55CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21536621
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20185600
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19170322
58YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18248868
59NANOG_16518401_ChIP-PET_MESCs_Mouse1.17857892
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15332232
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.14928920
62SOX9_26525672_Chip-Seq_HEART_Mouse1.14231359
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.14160968
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13933240
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.13110285
66TAF15_26573619_Chip-Seq_HEK293_Human1.12340483
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11036253
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.10461922
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09995076
70NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09928494
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09706732
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.09701626
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08307817
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08118461
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07933598
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07920685
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07920685
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06335532
79SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05280165
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04858355
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04627225
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.04406582
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03046812
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02946919
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02436291
86CLOCK_20551151_ChIP-Seq_293T_Human1.01356314
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00969472
88SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00811873
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00423838
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98898275
91NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97818162
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.96375345
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96037276
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95794041
95SMAD4_21799915_ChIP-Seq_A2780_Human0.92357059
96MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92297543
97POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91835500
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.91437412
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90120734
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88718691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development4.67602258
2MP0002254_reproductive_system_inflammat3.40976967
3MP0003890_abnormal_embryonic-extraembry3.10446553
4MP0003136_yellow_coat_color2.76633557
5MP0010030_abnormal_orbit_morphology2.54573039
6MP0001293_anophthalmia2.27817222
7MP0009672_abnormal_birth_weight2.24309566
8MP0003937_abnormal_limbs/digits/tail_de2.16666142
9MP0000579_abnormal_nail_morphology2.11097916
10MP0004957_abnormal_blastocyst_morpholog2.01774034
11MP0001299_abnormal_eye_distance/1.89608608
12MP0002697_abnormal_eye_size1.87170571
13MP0001984_abnormal_olfaction1.84562081
14MP0003693_abnormal_embryo_hatching1.82507447
15MP0001177_atelectasis1.80295351
16MP0003119_abnormal_digestive_system1.79039157
17MP0008932_abnormal_embryonic_tissue1.76750668
18MP0000537_abnormal_urethra_morphology1.75440630
19MP0004272_abnormal_basement_membrane1.72793871
20MP0003111_abnormal_nucleus_morphology1.61042862
21MP0004133_heterotaxia1.59747174
22MP0010352_gastrointestinal_tract_polyps1.58337187
23MP0002233_abnormal_nose_morphology1.53933033
24MP0002084_abnormal_developmental_patter1.53123313
25MP0009703_decreased_birth_body1.53113977
26MP0000049_abnormal_middle_ear1.53070501
27MP0010094_abnormal_chromosome_stability1.51856142
28MP0001188_hyperpigmentation1.51543731
29MP0008057_abnormal_DNA_replication1.49818380
30MP0006292_abnormal_olfactory_placode1.49349724
31MP0000428_abnormal_craniofacial_morphol1.48153222
32MP0002085_abnormal_embryonic_tissue1.47160559
33MP0000762_abnormal_tongue_morphology1.43178936
34MP0003567_abnormal_fetal_cardiomyocyte1.41285144
35MP0001730_embryonic_growth_arrest1.40730844
36MP0001286_abnormal_eye_development1.38660948
37MP0000778_abnormal_nervous_system1.36353167
38MP0004270_analgesia1.35499617
39MP0002111_abnormal_tail_morphology1.32186121
40MP0003861_abnormal_nervous_system1.25321882
41MP0000566_synostosis1.22645934
42MP0000432_abnormal_head_morphology1.22416058
43MP0001849_ear_inflammation1.21896664
44MP0008877_abnormal_DNA_methylation1.20759148
45MP0005380_embryogenesis_phenotype1.20263642
46MP0001672_abnormal_embryogenesis/_devel1.20263642
47MP0002092_abnormal_eye_morphology1.20134785
48MP0003755_abnormal_palate_morphology1.19367638
49MP0001529_abnormal_vocalization1.17973040
50MP0003077_abnormal_cell_cycle1.14699374
51MP0001485_abnormal_pinna_reflex1.13458433
52MP0008058_abnormal_DNA_repair1.13209479
53MP0003122_maternal_imprinting1.11366917
54MP0005499_abnormal_olfactory_system1.10048896
55MP0005394_taste/olfaction_phenotype1.10048896
56MP0004197_abnormal_fetal_growth/weight/1.08452295
57MP0008007_abnormal_cellular_replicative1.07320284
58MP0003718_maternal_effect1.06560565
59MP0003984_embryonic_growth_retardation1.04102058
60MP0008789_abnormal_olfactory_epithelium1.04013088
61MP0003566_abnormal_cell_adhesion1.03454147
62MP0009250_abnormal_appendicular_skeleto1.02908706
63MP0003942_abnormal_urinary_system1.01616033
64MP0002088_abnormal_embryonic_growth/wei1.01373832
65MP0002938_white_spotting1.01330047
66MP0003385_abnormal_body_wall0.99771314
67MP0003705_abnormal_hypodermis_morpholog0.98850418
68MP0003935_abnormal_craniofacial_develop0.97254877
69MP0004859_abnormal_synaptic_plasticity0.96991637
70MP0005377_hearing/vestibular/ear_phenot0.95008452
71MP0003878_abnormal_ear_physiology0.95008452
72MP0009384_cardiac_valve_regurgitation0.93566101
73MP0004782_abnormal_surfactant_physiolog0.92572700
74MP0002090_abnormal_vision0.92313233
75MP0001697_abnormal_embryo_size0.91889700
76MP0000751_myopathy0.90657249
77MP0000350_abnormal_cell_proliferation0.90564223
78MP0003121_genomic_imprinting0.89284059
79MP0003938_abnormal_ear_development0.88621399
80MP0002736_abnormal_nociception_after0.88464229
81MP0002116_abnormal_craniofacial_bone0.87665682
82MP0003137_abnormal_impulse_conducting0.87447110
83MP0003115_abnormal_respiratory_system0.85948442
84MP0002734_abnormal_mechanical_nocicepti0.85828543
85MP0002152_abnormal_brain_morphology0.84064378
86MP0005391_vision/eye_phenotype0.82739459
87MP0002081_perinatal_lethality0.82677287
88MP0001915_intracranial_hemorrhage0.82402372
89MP0001486_abnormal_startle_reflex0.82062806
90MP0002080_prenatal_lethality0.81358398
91MP0000534_abnormal_ureter_morphology0.79834140
92MP0002653_abnormal_ependyma_morphology0.79104013
93MP0000955_abnormal_spinal_cord0.78939878
94MP0010307_abnormal_tumor_latency0.78908583
95MP0005623_abnormal_meninges_morphology0.74991106
96MP0005388_respiratory_system_phenotype0.73987564
97MP0002133_abnormal_respiratory_system0.73987564
98MP0005248_abnormal_Harderian_gland0.73568193
99MP0010630_abnormal_cardiac_muscle0.73106093
100MP0003690_abnormal_glial_cell0.73011469

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.34983255
2Septo-optic dysplasia (HP:0100842)4.34084746
3Hepatoblastoma (HP:0002884)4.25678913
4Exercise-induced muscle cramps (HP:0003710)3.50549403
5Abnormality of the labia minora (HP:0012880)3.35258073
6Spastic diplegia (HP:0001264)3.27230176
7Choanal stenosis (HP:0000452)3.04705304
8Cortical dysplasia (HP:0002539)2.92964069
9Cutaneous syndactyly (HP:0012725)2.84023400
10Maternal diabetes (HP:0009800)2.81174140
11Cutaneous finger syndactyly (HP:0010554)2.67840182
12Nephroblastoma (Wilms tumor) (HP:0002667)2.65453287
13Aplasia involving bones of the extremities (HP:0009825)2.58393982
14Aplasia involving bones of the upper limbs (HP:0009823)2.58393982
15Aplasia of the phalanges of the hand (HP:0009802)2.58393982
16Embryonal renal neoplasm (HP:0011794)2.56237339
17Selective tooth agenesis (HP:0001592)2.50721856
18Partial duplication of thumb phalanx (HP:0009944)2.50403312
19Absent septum pellucidum (HP:0001331)2.47461890
20Chronic bronchitis (HP:0004469)2.42064807
21Bifid tongue (HP:0010297)2.40408301
22Abnormal lung lobation (HP:0002101)2.38704871
23Medulloblastoma (HP:0002885)2.37167440
24Turricephaly (HP:0000262)2.36643094
25Abnormality of the septum pellucidum (HP:0007375)2.36082486
26Hyperglycinemia (HP:0002154)2.35373677
27Myelomeningocele (HP:0002475)2.33378562
28Short hallux (HP:0010109)2.28856538
29Bilateral microphthalmos (HP:0007633)2.28782697
30Esophageal atresia (HP:0002032)2.28152376
31Aplasia/Hypoplasia of the sternum (HP:0006714)2.26959863
32Aplasia/Hypoplasia of the hallux (HP:0008362)2.22791166
33Omphalocele (HP:0001539)2.21853158
34Coronal craniosynostosis (HP:0004440)2.21788524
35Shallow orbits (HP:0000586)2.18588280
36Ependymoma (HP:0002888)2.11516104
37Split foot (HP:0001839)2.09790893
38Preaxial foot polydactyly (HP:0001841)2.07809309
39Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06016924
40Anophthalmia (HP:0000528)2.05678655
41Agnosia (HP:0010524)2.04058440
42Optic nerve hypoplasia (HP:0000609)2.02464540
43Broad metatarsal (HP:0001783)2.02093763
44Hypoglycemic seizures (HP:0002173)2.00512705
45Partial duplication of the phalanx of hand (HP:0009999)1.99767638
46Rhabdomyosarcoma (HP:0002859)1.97591051
47Skull defect (HP:0001362)1.97559966
48Calcaneovalgus deformity (HP:0001848)1.95642096
49Bronchomalacia (HP:0002780)1.95201785
50Supernumerary spleens (HP:0009799)1.94774088
51Gastrointestinal carcinoma (HP:0002672)1.93845525
52Malignant gastrointestinal tract tumors (HP:0006749)1.93845525
53Multiple enchondromatosis (HP:0005701)1.93783910
54Arnold-Chiari malformation (HP:0002308)1.93779410
55Aplasia/Hypoplasia of the breasts (HP:0010311)1.90179064
56Renal hypoplasia (HP:0000089)1.89970250
57Breast aplasia (HP:0100783)1.89838017
58Abnormality of the middle phalanges of the toes (HP:0010183)1.85116622
59Vitreoretinal degeneration (HP:0000655)1.84195332
60Pancreatic islet-cell hyperplasia (HP:0004510)1.83347506
61Birth length less than 3rd percentile (HP:0003561)1.81749971
62Stenosis of the external auditory canal (HP:0000402)1.81602108
63Broad thumb (HP:0011304)1.81357253
64Aqueductal stenosis (HP:0002410)1.80803798
65Abnormal hair whorl (HP:0010721)1.78893688
66Absent eyebrow (HP:0002223)1.78442853
67Deformed tarsal bones (HP:0008119)1.76424783
68Vertebral clefting (HP:0008428)1.75716936
69Duplication of thumb phalanx (HP:0009942)1.74969722
70Abnormality of glycine metabolism (HP:0010895)1.74955514
71Abnormality of serine family amino acid metabolism (HP:0010894)1.74955514
72Increased nuchal translucency (HP:0010880)1.74868749
73Gastrointestinal atresia (HP:0002589)1.73232174
74Hyperglycinuria (HP:0003108)1.73174909
75Abdominal situs inversus (HP:0003363)1.72315577
76Abnormality of abdominal situs (HP:0011620)1.72315577
77Facial cleft (HP:0002006)1.70972492
78Abnormality of cochlea (HP:0000375)1.70254897
79Rocker bottom foot (HP:0001838)1.69803670
80Absent eyelashes (HP:0000561)1.67948934
81Absent toe (HP:0010760)1.66568858
82Midline defect of the nose (HP:0004122)1.65380952
83Trigonocephaly (HP:0000243)1.64521445
84Glioma (HP:0009733)1.64001206
85Nasal speech (HP:0001611)1.63878519
86Generalized hypotonia (HP:0001290)1.62044998
87Hyperinsulinemic hypoglycemia (HP:0000825)1.59799449
88Pterygium (HP:0001059)1.59784096
89Hemivertebrae (HP:0002937)1.57875475
90Broad foot (HP:0001769)1.56910124
91Abnormality of the astrocytes (HP:0100707)1.56164041
92Astrocytoma (HP:0009592)1.56164041
93Abnormality of the salivary glands (HP:0010286)1.55815018
94Abnormality of the antihelix (HP:0009738)1.55634308
95Broad long bones (HP:0005622)1.55108320
96Missing ribs (HP:0000921)1.53587641
97Meckel diverticulum (HP:0002245)1.52556972
98Scrotal hypoplasia (HP:0000046)1.51890474
99Chromosomal breakage induced by crosslinking agents (HP:0003221)1.51383721
100Papillary thyroid carcinoma (HP:0002895)1.49865608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.66087947
2CASK3.01816464
3MKNK22.99819011
4TNIK2.95156307
5TSSK62.88867588
6TTK2.84252746
7MKNK12.73000405
8TAF12.30513974
9STK38L2.08713369
10PBK2.08360599
11PLK31.98228498
12MAP3K101.83842674
13LATS21.81217392
14SRPK11.74504704
15LATS11.72999910
16BUB11.71160223
17WNK31.71039802
18DYRK21.67098650
19OBSCN1.63646854
20FGFR21.59249687
21CDK191.46043413
22CAMK1G1.41723160
23CSNK1G11.41541451
24DMPK1.30702739
25NTRK11.23266241
26CAMK1D1.22944237
27PNCK1.21384217
28MAP3K91.21322547
29CSNK1G21.19849613
30FGFR11.19350188
31PLK41.18932796
32ZAK1.16440106
33VRK21.15993793
34NEK11.15502638
35PLK11.15494236
36NTRK21.12479508
37MST41.11267154
38STK241.08657557
39ERBB41.07393359
40NLK1.05251830
41DYRK31.02870660
42MARK10.97676272
43TRIM280.97619283
44ALK0.96840328
45STK30.96837330
46TIE10.90508777
47EEF2K0.90120446
48CSNK1G30.83845253
49PDGFRA0.83269194
50VRK10.83171659
51PAK40.82086925
52BCR0.80147290
53CSNK1A1L0.78937746
54NME10.76741247
55CHEK20.74849475
56TYRO30.74819864
57SMG10.74017010
58ROCK20.72771567
59ATM0.71619741
60MAP3K40.69751862
61BMPR1B0.69178864
62BRSK20.68778544
63PRKDC0.68174700
64PLK20.68095364
65PINK10.65468586
66ATR0.65240037
67EIF2AK20.64717486
68WEE10.64426030
69TTN0.63578867
70SGK20.60543711
71CHEK10.58769727
72NUAK10.58212930
73BMX0.56654437
74YES10.56172286
75CSNK1E0.56118317
76OXSR10.55652551
77BRD40.55054035
78AURKB0.54788914
79DYRK1A0.53972098
80SGK2230.53813025
81SGK4940.53813025
82CDK30.53281857
83CDK60.51943520
84TGFBR10.49508732
85CDK120.48030476
86CDK10.47004475
87ACVR1B0.43920494
88CDK20.43655855
89CSNK1D0.41457717
90MAPK150.40387739
91EPHA40.40052811
92EPHB20.39189573
93CDK180.38539535
94PRKCG0.38166482
95NEK20.37815679
96CDK150.37799808
97CDK140.37790314
98CAMK2A0.37461920
99EGFR0.36625670
100NEK60.36075147

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.65505641
2DNA replication_Homo sapiens_hsa030302.31015086
3Non-homologous end-joining_Homo sapiens_hsa034502.28428784
4Basal cell carcinoma_Homo sapiens_hsa052172.25259658
5Adherens junction_Homo sapiens_hsa045202.24298284
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21579470
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.21181128
8Steroid biosynthesis_Homo sapiens_hsa001002.16977538
9Hippo signaling pathway_Homo sapiens_hsa043902.07269143
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.02656541
11Cysteine and methionine metabolism_Homo sapiens_hsa002702.00809118
12Tight junction_Homo sapiens_hsa045301.89315358
13Wnt signaling pathway_Homo sapiens_hsa043101.81383351
14Cell cycle_Homo sapiens_hsa041101.80545456
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80415297
16Vitamin B6 metabolism_Homo sapiens_hsa007501.69074395
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63570875
18RNA transport_Homo sapiens_hsa030131.62523813
19Spliceosome_Homo sapiens_hsa030401.61508203
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61385831
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60843536
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53506211
23Pyruvate metabolism_Homo sapiens_hsa006201.50842824
24Propanoate metabolism_Homo sapiens_hsa006401.50124458
25mRNA surveillance pathway_Homo sapiens_hsa030151.49768217
26Hedgehog signaling pathway_Homo sapiens_hsa043401.45941474
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43308556
28Biosynthesis of amino acids_Homo sapiens_hsa012301.40180872
29Selenocompound metabolism_Homo sapiens_hsa004501.32917516
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32410612
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26713561
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25897876
33Dilated cardiomyopathy_Homo sapiens_hsa054141.23944793
34TGF-beta signaling pathway_Homo sapiens_hsa043501.23323823
35Base excision repair_Homo sapiens_hsa034101.15676126
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15150857
37ECM-receptor interaction_Homo sapiens_hsa045121.11268999
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11006920
39RNA degradation_Homo sapiens_hsa030181.04427273
40Oocyte meiosis_Homo sapiens_hsa041141.03886028
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02951156
42Melanogenesis_Homo sapiens_hsa049161.01439401
43Fanconi anemia pathway_Homo sapiens_hsa034601.00600542
44Basal transcription factors_Homo sapiens_hsa030221.00250679
45RNA polymerase_Homo sapiens_hsa030200.99286026
46Fatty acid metabolism_Homo sapiens_hsa012120.98618520
47One carbon pool by folate_Homo sapiens_hsa006700.98608903
48Lysine degradation_Homo sapiens_hsa003100.98519688
49Thyroid cancer_Homo sapiens_hsa052160.97685345
50MicroRNAs in cancer_Homo sapiens_hsa052060.97278497
51Arginine and proline metabolism_Homo sapiens_hsa003300.97029723
52Fatty acid elongation_Homo sapiens_hsa000620.96790476
53Axon guidance_Homo sapiens_hsa043600.96197269
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95254913
55Homologous recombination_Homo sapiens_hsa034400.95126015
56Carbon metabolism_Homo sapiens_hsa012000.92828076
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92494038
58Colorectal cancer_Homo sapiens_hsa052100.90460352
59beta-Alanine metabolism_Homo sapiens_hsa004100.89972563
60Nucleotide excision repair_Homo sapiens_hsa034200.88090101
61Nicotine addiction_Homo sapiens_hsa050330.80773577
62Cardiac muscle contraction_Homo sapiens_hsa042600.77210096
63Protein digestion and absorption_Homo sapiens_hsa049740.76627796
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74878410
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.74118621
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72474945
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70409635
68Notch signaling pathway_Homo sapiens_hsa043300.65445743
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65400730
70Protein export_Homo sapiens_hsa030600.64708224
71Proteasome_Homo sapiens_hsa030500.59454163
72Gastric acid secretion_Homo sapiens_hsa049710.58878624
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58828730
74Gap junction_Homo sapiens_hsa045400.58728007
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58037612
76Thyroid hormone synthesis_Homo sapiens_hsa049180.56076535
77Proteoglycans in cancer_Homo sapiens_hsa052050.55106517
78Purine metabolism_Homo sapiens_hsa002300.54511860
79Endometrial cancer_Homo sapiens_hsa052130.52926791
80p53 signaling pathway_Homo sapiens_hsa041150.52480179
81Glutamatergic synapse_Homo sapiens_hsa047240.51987725
82Pathways in cancer_Homo sapiens_hsa052000.51734593
83Vitamin digestion and absorption_Homo sapiens_hsa049770.51516129
84Fatty acid degradation_Homo sapiens_hsa000710.50571599
85Folate biosynthesis_Homo sapiens_hsa007900.49454395
86Focal adhesion_Homo sapiens_hsa045100.49107889
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47247488
88Melanoma_Homo sapiens_hsa052180.46233719
89GABAergic synapse_Homo sapiens_hsa047270.46220245
90Rap1 signaling pathway_Homo sapiens_hsa040150.45548077
91Prostate cancer_Homo sapiens_hsa052150.45175066
92Glutathione metabolism_Homo sapiens_hsa004800.44483362
93Histidine metabolism_Homo sapiens_hsa003400.40816115
94Taste transduction_Homo sapiens_hsa047420.40496227
95Glucagon signaling pathway_Homo sapiens_hsa049220.36918744
96Circadian rhythm_Homo sapiens_hsa047100.35962833
97Alcoholism_Homo sapiens_hsa050340.34648594
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32854898
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32539222
100Long-term depression_Homo sapiens_hsa047300.31945297

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