ANO9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)7.88232145
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.73475065
3sphingoid metabolic process (GO:0046519)7.15221772
4keratinocyte differentiation (GO:0030216)6.82661189
5keratinocyte proliferation (GO:0043616)6.74310865
6water homeostasis (GO:0030104)6.47597380
7hair cycle (GO:0042633)6.38933180
8molting cycle (GO:0042303)6.38933180
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.14279808
10hemidesmosome assembly (GO:0031581)6.09658201
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99518451
12epidermal cell differentiation (GO:0009913)5.91544915
13intermediate filament organization (GO:0045109)5.86315933
14sphingosine metabolic process (GO:0006670)5.81783324
15diol metabolic process (GO:0034311)5.81496138
16negative regulation of keratinocyte proliferation (GO:0010839)5.78608778
17antigen processing and presentation of endogenous antigen (GO:0019883)5.77850425
18intestinal epithelial cell development (GO:0060576)5.43900755
19peptide cross-linking (GO:0018149)5.32796388
20regulation of transforming growth factor beta1 production (GO:0032908)5.25760306
21epidermis development (GO:0008544)5.19579365
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02493167
23regulation of ruffle assembly (GO:1900027)4.99113783
24keratinocyte development (GO:0003334)4.97569964
25skin morphogenesis (GO:0043589)4.97022383
26detection of bacterium (GO:0016045)4.81418965
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74055010
28negative regulation of cell killing (GO:0031342)4.74055010
29viral transcription (GO:0019083)4.65036856
30translational termination (GO:0006415)4.44374953
31negative regulation of cell fate specification (GO:0009996)4.33133821
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.27196406
33thymic T cell selection (GO:0045061)4.25471224
34regulation of cell proliferation involved in kidney development (GO:1901722)4.24347283
35angiotensin maturation (GO:0002003)4.23948500
36negative thymic T cell selection (GO:0045060)4.23411651
37ribosomal small subunit biogenesis (GO:0042274)4.22977906
38ectoderm development (GO:0007398)4.18135588
39negative T cell selection (GO:0043383)4.12008815
40regulation of dendritic cell antigen processing and presentation (GO:0002604)4.11166651
41positive regulation of epidermis development (GO:0045684)4.06308534
42positive regulation of gamma-delta T cell activation (GO:0046645)4.01172970
43long-chain fatty acid biosynthetic process (GO:0042759)3.94556339
44detection of other organism (GO:0098543)3.94314728
45regulation of chemokine secretion (GO:0090196)3.91679584
46positive regulation of interleukin-8 secretion (GO:2000484)3.91266502
47positive thymic T cell selection (GO:0045059)3.89323499
48NIK/NF-kappaB signaling (GO:0038061)3.88670532
49calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.87853505
50interferon-gamma secretion (GO:0072643)3.83045587
51regulation of cellular extravasation (GO:0002691)3.81891441
52regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.76909826
53regulation of phospholipase A2 activity (GO:0032429)3.75863703
54T cell selection (GO:0045058)3.75783052
55ribosomal large subunit biogenesis (GO:0042273)3.74841134
56phosphatidylinositol acyl-chain remodeling (GO:0036149)3.71899203
57positive regulation of hair cycle (GO:0042635)3.71191370
58positive regulation of hair follicle development (GO:0051798)3.71191370
59positive regulation of epidermal cell differentiation (GO:0045606)3.68186473
60maturation of SSU-rRNA (GO:0030490)3.67078967
61regulation of gamma-delta T cell differentiation (GO:0045586)3.62648696
62viral life cycle (GO:0019058)3.62335531
63regulation of keratinocyte proliferation (GO:0010837)3.61700395
64translational elongation (GO:0006414)3.61486927
65epithelial cell-cell adhesion (GO:0090136)3.59874076
66intermediate filament cytoskeleton organization (GO:0045104)3.57416596
67negative regulation of cell fate commitment (GO:0010454)3.57399719
68regulation of gamma-delta T cell activation (GO:0046643)3.53721529
69cellular protein complex disassembly (GO:0043624)3.50705020
70regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.50609235
71positive regulation of Cdc42 GTPase activity (GO:0043089)3.47141488
72intermediate filament-based process (GO:0045103)3.46392771
73mannose metabolic process (GO:0006013)3.45212460
74regulation of cardioblast differentiation (GO:0051890)3.41413640
75phosphatidylserine acyl-chain remodeling (GO:0036150)3.40931220
76protein targeting to ER (GO:0045047)3.39535108
77chemical homeostasis within a tissue (GO:0048875)3.39467588
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38931770
79ventricular cardiac muscle cell action potential (GO:0086005)3.38895467
80transepithelial transport (GO:0070633)3.36693334
81tolerance induction (GO:0002507)3.34555242
82signal complex assembly (GO:0007172)3.34465498
83positive regulation of antigen processing and presentation (GO:0002579)3.33103676
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31892327
85phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.31240971
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31151561
87positive T cell selection (GO:0043368)3.30760717
88cotranslational protein targeting to membrane (GO:0006613)3.28909989
89cyclooxygenase pathway (GO:0019371)3.27213460
90negative regulation of stress fiber assembly (GO:0051497)3.27204593
91positive regulation of glomerulus development (GO:0090193)3.24373652
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22837518
93eyelid development in camera-type eye (GO:0061029)3.22248853
94intestinal absorption (GO:0050892)3.19159657
95regulation of hair follicle development (GO:0051797)3.17864489
96regulation of extracellular matrix disassembly (GO:0010715)3.16927531
97response to type I interferon (GO:0034340)3.15736851
98glucosamine-containing compound catabolic process (GO:1901072)3.14750747
99response to phenylpropanoid (GO:0080184)3.14686540
100immunoglobulin mediated immune response (GO:0016064)3.14219679
101regulation of antigen processing and presentation (GO:0002577)3.12924884
102regulation of guanylate cyclase activity (GO:0031282)3.12773973
103protein localization to endoplasmic reticulum (GO:0070972)3.12254636
104regulation of apoptotic process involved in morphogenesis (GO:1902337)3.11966584
105translational initiation (GO:0006413)3.11624457
106regulation of epidermis development (GO:0045682)3.10006248
107regulation of T cell tolerance induction (GO:0002664)3.09640895
108regulation of interleukin-8 secretion (GO:2000482)3.09260646
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08211139
110type I interferon signaling pathway (GO:0060337)3.08080888
111cellular response to type I interferon (GO:0071357)3.08080888
112phospholipid efflux (GO:0033700)3.05906454
113regulation of cholesterol homeostasis (GO:2000188)3.04889621
114tight junction assembly (GO:0070830)2.99752336
115T cell costimulation (GO:0031295)2.99417389
116antigen processing and presentation via MHC class Ib (GO:0002475)2.98992240
117dendritic cell chemotaxis (GO:0002407)2.98457891
118ribosomal small subunit assembly (GO:0000028)2.98139143
119protein complex disassembly (GO:0043241)2.96133636
120trophectodermal cell differentiation (GO:0001829)2.94609807
121lymphocyte costimulation (GO:0031294)2.94481141
122hormone catabolic process (GO:0042447)2.94457504
123germinal center formation (GO:0002467)2.92535592
124surfactant homeostasis (GO:0043129)2.90965021
125linoleic acid metabolic process (GO:0043651)2.90862125
126diacylglycerol metabolic process (GO:0046339)2.90575419
127antibacterial humoral response (GO:0019731)2.89916435
128atrioventricular valve morphogenesis (GO:0003181)2.89818052
129B cell receptor signaling pathway (GO:0050853)2.89439731
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.89186033
131positive regulation of pseudopodium assembly (GO:0031274)2.88480957
132phosphatidylcholine acyl-chain remodeling (GO:0036151)2.87164450
133antimicrobial humoral response (GO:0019730)2.87135859
134regulation of B cell receptor signaling pathway (GO:0050855)2.86922982
135negative regulation of erythrocyte differentiation (GO:0045647)2.85324858
136negative regulation of epidermal cell differentiation (GO:0045605)2.84236361
137fatty acid elongation (GO:0030497)2.82990244
138interferon-gamma-mediated signaling pathway (GO:0060333)2.82557449
139leukocyte aggregation (GO:0070486)2.81759873
140NADH metabolic process (GO:0006734)2.78521752
141regulation of regulatory T cell differentiation (GO:0045589)2.77703563
142phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77531887
143maintenance of gastrointestinal epithelium (GO:0030277)2.77466968
144regulation of Cdc42 GTPase activity (GO:0043088)2.77187300
145positive regulation of chemokine secretion (GO:0090197)2.75844305
146regulation of alpha-beta T cell proliferation (GO:0046640)2.75371106
147regulation of keratinocyte differentiation (GO:0045616)2.74755417
148negative regulation of epidermis development (GO:0045683)2.72787208
149regulation of respiratory burst (GO:0060263)2.71971807
150negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.71669034
151CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.69132714
152regulation of necroptotic process (GO:0060544)2.65762987
153negative regulation of lymphocyte mediated immunity (GO:0002707)2.65655620
154T cell receptor signaling pathway (GO:0050852)2.65045540
155peptide catabolic process (GO:0043171)2.64680982
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64642813
157response to interleukin-15 (GO:0070672)2.64242653
158epoxygenase P450 pathway (GO:0019373)2.61935540
159response to muramyl dipeptide (GO:0032495)2.60328787
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60220209
161fat-soluble vitamin biosynthetic process (GO:0042362)2.59951566
162antigen receptor-mediated signaling pathway (GO:0050851)2.58493140
163regulation of interferon-beta biosynthetic process (GO:0045357)2.57875200
164regulation of tolerance induction (GO:0002643)2.57286502
165T cell migration (GO:0072678)2.57210959
166embryonic process involved in female pregnancy (GO:0060136)2.56093983
167histone H3-K36 demethylation (GO:0070544)2.54224529
168negative regulation of innate immune response (GO:0045824)2.52665655
169regulation of pseudopodium assembly (GO:0031272)2.50646531
170lipoprotein transport (GO:0042953)2.49620579
171regulation of T cell mediated cytotoxicity (GO:0001914)2.49026888
172dendritic cell migration (GO:0036336)2.47897069
173positive regulation of respiratory burst (GO:0060267)2.47344893
174negative regulation of T cell mediated immunity (GO:0002710)2.46864766
175negative regulation of leukocyte mediated immunity (GO:0002704)2.46822671
176myeloid dendritic cell differentiation (GO:0043011)2.46649912
177regulation of necrotic cell death (GO:0010939)2.44258963
178regulation of bile acid biosynthetic process (GO:0070857)2.43891738
179positive regulation of Rap GTPase activity (GO:0032854)2.43508903
180modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42697228
181positive regulation by organism of defense response of other organism involved in symbiotic interact2.42697228
182modulation by symbiont of host immune response (GO:0052553)2.42697228
183positive regulation by symbiont of host defense response (GO:0052509)2.42697228
184modulation by symbiont of host defense response (GO:0052031)2.42697228
185modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42697228
186cellular response to virus (GO:0098586)2.42683454
187regulation of interleukin-2 biosynthetic process (GO:0045076)2.41759008
188plasma lipoprotein particle assembly (GO:0034377)2.40671659
189detection of external biotic stimulus (GO:0098581)2.40439168
190desmosome organization (GO:0002934)14.7644533
191establishment of skin barrier (GO:0061436)12.7112643
192regulation of water loss via skin (GO:0033561)11.9296882
193keratinization (GO:0031424)10.6250734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.17814370
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.91907356
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92961798
4MYC_22102868_ChIP-Seq_BL_Human2.81184784
5P63_26484246_Chip-Seq_KERATINOCYTES_Human2.78901068
6VDR_21846776_ChIP-Seq_THP-1_Human2.60147178
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59441979
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.57380418
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.56418751
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51666562
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.47062256
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.46744893
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.46744893
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.46744893
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41876015
16E2F7_22180533_ChIP-Seq_HELA_Human2.31591598
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28128691
18TCF7_22412390_ChIP-Seq_EML_Mouse2.22395393
19ZNF263_19887448_ChIP-Seq_K562_Human2.22221378
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17337053
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14824711
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12089003
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.08070755
24MAF_26560356_Chip-Seq_TH1_Human2.07497795
25ELK3_25401928_ChIP-Seq_HUVEC_Human2.04568419
26TP63_17297297_ChIP-ChIP_HaCaT_Human14.9998863
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97670379
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94164598
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94164598
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.92283847
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91312482
32VDR_24763502_ChIP-Seq_THP-1_Human1.90739086
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90243942
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.89254705
35KDM2B_26808549_Chip-Seq_DND41_Human1.88465455
36UTX_26944678_Chip-Seq_JUKART_Human1.88162715
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83142488
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.82934955
39GATA4_25053715_ChIP-Seq_YYC3_Human1.81906313
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81876303
41SOX2_20726797_ChIP-Seq_SW620_Human1.79571664
42GATA6_25053715_ChIP-Seq_YYC3_Human1.76799377
43CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74051736
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.70887746
45RUNX_20019798_ChIP-Seq_JUKART_Human1.70174929
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.69036341
47MAF_26560356_Chip-Seq_TH2_Human1.68563312
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67612234
49ATF3_27146783_Chip-Seq_COLON_Human1.66109966
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65077123
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.64338336
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.62474535
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.62413015
54MYB_26560356_Chip-Seq_TH1_Human1.62292664
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.58914762
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58235357
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55404649
58MYB_26560356_Chip-Seq_TH2_Human1.55248632
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55103249
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54485207
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54139267
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53867235
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.52776506
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51410201
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51301381
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50188244
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47473667
68KLF5_25053715_ChIP-Seq_YYC3_Human1.47171119
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44537684
70* BCL6_27268052_Chip-Seq_Bcells_Human1.43666203
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42627817
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39945826
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.38644718
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38168724
75* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36722494
76TCF3_18692474_ChIP-Seq_MESCs_Mouse1.35522532
77ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33073456
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32637042
79* RACK7_27058665_Chip-Seq_MCF-7_Human1.32470530
80GATA3_24758297_ChIP-Seq_MCF-7_Human1.30731532
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29382086
82IRF8_27001747_Chip-Seq_BMDM_Mouse1.29065370
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25320191
84IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25014188
85SCL_19346495_ChIP-Seq_HPC-7_Human1.24881660
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.24550250
87* TP63_22573176_ChIP-Seq_HFKS_Human1.24041386
88NCOR1_26117541_ChIP-Seq_K562_Human1.22516811
89* BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22369080
90SMC4_20622854_ChIP-Seq_HELA_Human1.21981889
91SPI1_23127762_ChIP-Seq_K562_Human1.21864183
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.21562981
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19954446
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18457741
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17356174
96ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17296948
97CREB1_26743006_Chip-Seq_LNCaP_Human1.17261340
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17086461
99KDM2B_26808549_Chip-Seq_K562_Human1.16563775
100GATA1_19941826_ChIP-Seq_K562_Human1.16441770
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.15230797
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15130457
103GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14734638
104NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13966564
105CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13034722
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12943787
107SPI1_23547873_ChIP-Seq_NB4_Human1.12854393
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12228851
109TP63_23658742_ChIP-Seq_EP156T_Human1.11466601
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11400569
111POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10810723
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10244499
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09985405
114NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09486041
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09454842
116MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07850656
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07582179
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06358936
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05356194
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05090804
121ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04317784
122GATA3_27048872_Chip-Seq_THYMUS_Human1.02616931
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02352587
124* SA1_27219007_Chip-Seq_Bcells_Human1.02176302
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01800461
126PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00809496
127SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97802725
128NANOG_18692474_ChIP-Seq_MESCs_Mouse0.96003944
129AR_21909140_ChIP-Seq_LNCAP_Human0.95899490
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94383680
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92496063
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92374258
133SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90682963
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90522117
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89520348
136SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87694259
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.86176198
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85091910
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83865980
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83661363
141EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82722082
142CEBPB_22108803_ChIP-Seq_LS180_Human0.82011483
143PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81492224
144GATA6_21074721_ChIP-Seq_CACO-2_Human0.80577919
145NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80210835
146FOXM1_23109430_ChIP-Seq_U2OS_Human0.80195066
147CJUN_26792858_Chip-Seq_BT549_Human0.79805045
148UBF1/2_26484160_Chip-Seq_HMECs_Human0.79116041
149CTCF_27219007_Chip-Seq_Bcells_Human0.76699430
150* BCOR_27268052_Chip-Seq_Bcells_Human0.74809133
151RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74353452
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.72795432
153SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72743860
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72664750
155* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71413360
156LXR_22292898_ChIP-Seq_THP-1_Human0.71178586
157JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70835054
158PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.69883430
159HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69138381
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.68630782
161OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68614687
162* SA1_27219007_Chip-Seq_ERYTHROID_Human0.68216803
163FOXA1_27270436_Chip-Seq_PROSTATE_Human0.66714049
164FOXA1_25329375_ChIP-Seq_VCAP_Human0.66714049
165RXR_22108803_ChIP-Seq_LS180_Human0.66628285
166NANOG_20526341_ChIP-Seq_ESCs_Human0.66317721
167RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65153027
168ESR1_15608294_ChIP-ChIP_MCF-7_Human0.64838521
169VDR_22108803_ChIP-Seq_LS180_Human0.64827531
170* P68_20966046_ChIP-Seq_HELA_Human0.64739464
171SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63440291
172NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.62992529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.64090335
2MP0010234_abnormal_vibrissa_follicle6.84988534
3MP0003941_abnormal_skin_development5.23610497
4MP0005275_abnormal_skin_tensile4.85197273
5MP0005501_abnormal_skin_physiology4.81816390
6MP0002060_abnormal_skin_morphology3.32364292
7MP0005451_abnormal_body_composition3.31203379
8MP0001216_abnormal_epidermal_layer3.23684132
9MP0004381_abnormal_hair_follicle3.16097249
10MP0002098_abnormal_vibrissa_morphology3.07706220
11MP0000579_abnormal_nail_morphology3.01297182
12MP0003763_abnormal_thymus_physiology2.94733810
13MP0003436_decreased_susceptibility_to2.93314805
14MP0010678_abnormal_skin_adnexa2.85928226
15MP0010771_integument_phenotype2.82605535
16MP0003453_abnormal_keratinocyte_physiol2.73157011
17MP0000647_abnormal_sebaceous_gland2.71201479
18MP0003705_abnormal_hypodermis_morpholog2.70181661
19MP0000685_abnormal_immune_system2.62332259
20MP0005671_abnormal_response_to2.61083486
21MP0000377_abnormal_hair_follicle2.50192039
22MP0004947_skin_inflammation2.46519226
23MP0001835_abnormal_antigen_presentation2.45590318
24MP0002254_reproductive_system_inflammat2.45381852
25MP0001800_abnormal_humoral_immune2.40748170
26MP0005387_immune_system_phenotype2.37518253
27MP0001790_abnormal_immune_system2.37518253
28MP0000383_abnormal_hair_follicle2.33143923
29MP0003724_increased_susceptibility_to2.31213694
30MP0003183_abnormal_peptide_metabolism2.25646414
31MP0002009_preneoplasia2.12456603
32MP0009333_abnormal_splenocyte_physiolog2.09669556
33MP0005000_abnormal_immune_tolerance2.01344823
34MP0005025_abnormal_response_to2.00850861
35MP0002139_abnormal_hepatobiliary_system2.00587241
36MP0000467_abnormal_esophagus_morphology1.98473664
37MP0009840_abnormal_foam_cell1.92599421
38MP0000537_abnormal_urethra_morphology1.88391531
39MP0000427_abnormal_hair_cycle1.86491053
40MP0002723_abnormal_immune_serum1.84543994
41MP0003315_abnormal_perineum_morphology1.82413130
42MP0002452_abnormal_antigen_presenting1.81114129
43MP0001819_abnormal_immune_cell1.79910023
44MP0002420_abnormal_adaptive_immunity1.79073656
45MP0009785_altered_susceptibility_to1.75217206
46MP0003303_peritoneal_inflammation1.74916065
47MP0004264_abnormal_extraembryonic_tissu1.70058017
48MP0002138_abnormal_hepatobiliary_system1.63874639
49MP0000762_abnormal_tongue_morphology1.63790181
50MP0009379_abnormal_foot_pigmentation1.63750819
51MP0001191_abnormal_skin_condition1.63566483
52MP0009931_abnormal_skin_appearance1.55424722
53MP0003566_abnormal_cell_adhesion1.54913189
54MP0002396_abnormal_hematopoietic_system1.54886618
55MP0002419_abnormal_innate_immunity1.49205819
56MP0005409_darkened_coat_color1.48006365
57MP0008260_abnormal_autophagy1.45625997
58MP0000716_abnormal_immune_system1.45457382
59MP0005365_abnormal_bile_salt1.44151781
60MP0002398_abnormal_bone_marrow1.42700440
61MP0000566_synostosis1.42516342
62MP0010352_gastrointestinal_tract_polyps1.42071519
63MP0001845_abnormal_inflammatory_respons1.42036483
64MP0001243_abnormal_dermal_layer1.38734413
65MP0005310_abnormal_salivary_gland1.37687758
66MP0000678_abnormal_parathyroid_gland1.32643188
67MP0003191_abnormal_cellular_cholesterol1.30060462
68MP0000367_abnormal_coat/_hair1.29699539
69MP0002148_abnormal_hypersensitivity_rea1.29015609
70MP0002405_respiratory_system_inflammati1.26338097
71MP0001533_abnormal_skeleton_physiology1.25935528
72MP0003172_abnormal_lysosome_physiology1.23602900
73MP0005367_renal/urinary_system_phenotyp1.23378753
74MP0000516_abnormal_urinary_system1.23378753
75MP0001346_abnormal_lacrimal_gland1.22501521
76MP0009053_abnormal_anal_canal1.21551833
77MP0001663_abnormal_digestive_system1.17037096
78MP0002429_abnormal_blood_cell1.14536153
79MP0000858_altered_metastatic_potential1.14197051
80MP0008004_abnormal_stomach_pH1.14120273
81MP0004185_abnormal_adipocyte_glucose1.12891289
82MP0004019_abnormal_vitamin_homeostasis1.12560764
83MP0000703_abnormal_thymus_morphology1.11702106
84MP0001765_abnormal_ion_homeostasis1.11660829
85MP0002722_abnormal_immune_system1.11656928
86MP0002933_joint_inflammation1.11473146
87MP0009643_abnormal_urine_homeostasis1.09294428
88MP0005058_abnormal_lysosome_morphology1.08066447
89MP0000689_abnormal_spleen_morphology1.06694273
90MP0005166_decreased_susceptibility_to1.05205779
91MP0008469_abnormal_protein_level1.04006829
92MP0006082_CNS_inflammation1.03292528
93MP0010329_abnormal_lipoprotein_level1.01521383
94MP0001666_abnormal_nutrient_absorption1.01493066
95MP0002136_abnormal_kidney_physiology1.01199864
96MP0003693_abnormal_embryo_hatching0.99778626
97MP0002998_abnormal_bone_remodeling0.97889879
98MP0003283_abnormal_digestive_organ0.94393581
99MP0001664_abnormal_digestion0.92466443
100MP0004858_abnormal_nervous_system0.92066220
101MP0005464_abnormal_platelet_physiology0.89970268
102MP0003045_fibrosis0.88717897
103MP0005666_abnormal_adipose_tissue0.88288844
104MP0004782_abnormal_surfactant_physiolog0.86983808
105MP0004957_abnormal_blastocyst_morpholog0.83752684
106MP0000609_abnormal_liver_physiology0.83610869
107MP0001851_eye_inflammation0.82722440
108MP0000462_abnormal_digestive_system0.79025010
109MP0002249_abnormal_larynx_morphology0.78955146
110MP0002234_abnormal_pharynx_morphology0.78458169
111MP0001340_abnormal_eyelid_morphology0.78313550
112MP0003136_yellow_coat_color0.78061436
113MP0001348_abnormal_lacrimal_gland0.72574035
114MP0000627_abnormal_mammary_gland0.72487231
115MP0005670_abnormal_white_adipose0.72238145
116MP0009278_abnormal_bone_marrow0.71010424
117MP0003868_abnormal_feces_composition0.70598987
118MP0005076_abnormal_cell_differentiation0.69637311
119MP0002277_abnormal_respiratory_mucosa0.66937772
120MP0003011_delayed_dark_adaptation0.65851973
121MP0001849_ear_inflammation0.65364019
122MP0001873_stomach_inflammation0.64424326
123MP0005360_urolithiasis0.64010333
124MP0000470_abnormal_stomach_morphology0.62702251
125MP0003950_abnormal_plasma_membrane0.61382279
126MP0000477_abnormal_intestine_morphology0.60846871
127MP0005187_abnormal_penis_morphology0.60377981
128MP0006054_spinal_hemorrhage0.57846838
129MP0005085_abnormal_gallbladder_physiolo0.56349098
130MP0000613_abnormal_salivary_gland0.55136024
131MP0003718_maternal_effect0.55128592
132MP0000538_abnormal_urinary_bladder0.54788070
133MP0000465_gastrointestinal_hemorrhage0.53191117
134MP0000490_abnormal_crypts_of0.52035985
135MP0002006_tumorigenesis0.51861875
136MP0002111_abnormal_tail_morphology0.51111326
137MP0005023_abnormal_wound_healing0.50596295
138MP0001784_abnormal_fluid_regulation0.48591150
139MP0010030_abnormal_orbit_morphology0.48084140
140MP0010155_abnormal_intestine_physiology0.46965210
141MP0003755_abnormal_palate_morphology0.46520020
142MP0003119_abnormal_digestive_system0.46491937
143MP0002233_abnormal_nose_morphology0.45823790
144MP0003866_abnormal_defecation0.44064065
145MP0002166_altered_tumor_susceptibility0.43980875
146MP0003936_abnormal_reproductive_system0.42501328
147MP0010386_abnormal_urinary_bladder0.41995593
148MP0009384_cardiac_valve_regurgitation0.39542071
149MP0004197_abnormal_fetal_growth/weight/0.39313061
150MP0003878_abnormal_ear_physiology0.38166052
151MP0005377_hearing/vestibular/ear_phenot0.38166052
152MP0000432_abnormal_head_morphology0.36483291
153MP0002697_abnormal_eye_size0.35850332
154MP0002822_catalepsy0.33677549
155MP0001286_abnormal_eye_development0.30742714
156MP0010307_abnormal_tumor_latency0.28590109
157MP0004272_abnormal_basement_membrane0.28279755
158MP0005075_abnormal_melanosome_morpholog0.26833187
159MP0002877_abnormal_melanocyte_morpholog0.26551605
160MP0005381_digestive/alimentary_phenotyp0.25825695
161MP0005508_abnormal_skeleton_morphology0.25457446
162MP0003300_gastrointestinal_ulcer0.25083353

Predicted human phenotypes

RankGene SetZ-score
1Congenital ichthyosiform erythroderma (HP:0007431)7.09282180
2Right ventricular cardiomyopathy (HP:0011663)7.04422057
3Hypotrichosis (HP:0001006)6.99629145
4Increased IgE level (HP:0003212)6.78619889
5Woolly hair (HP:0002224)6.44728305
6Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.29337043
7Abnormality of nail color (HP:0100643)6.06990743
8Parakeratosis (HP:0001036)5.92935120
9Plantar hyperkeratosis (HP:0007556)5.55542289
10Palmoplantar hyperkeratosis (HP:0000972)5.45062456
11Palmar hyperkeratosis (HP:0010765)5.19848997
12Eczematoid dermatitis (HP:0000976)5.15466473
13Onycholysis (HP:0001806)5.04650732
14Lip pit (HP:0100267)4.63494389
15Fragile nails (HP:0001808)4.63016907
16Pili torti (HP:0003777)4.51557492
17Erythroderma (HP:0001019)4.50876462
18Erythema (HP:0010783)4.18705288
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09916962
20Chronic diarrhea (HP:0002028)3.95090144
21Sparse eyelashes (HP:0000653)3.89685969
22Natal tooth (HP:0000695)3.77415244
23Gastrointestinal stroma tumor (HP:0100723)3.66756079
24Ventricular fibrillation (HP:0001663)3.61058707
25Abnormal blistering of the skin (HP:0008066)3.60221743
26Curly hair (HP:0002212)3.56357689
27Milia (HP:0001056)3.50187110
28Ventricular tachycardia (HP:0004756)3.48114587
29Ectropion (HP:0000656)3.44353779
30Colitis (HP:0002583)3.42851761
31Sparse scalp hair (HP:0002209)3.40947912
32Corneal erosion (HP:0200020)3.36674742
33Nail dystrophy (HP:0008404)3.34083905
34Gastrointestinal inflammation (HP:0004386)3.32427517
35Inflammation of the large intestine (HP:0002037)3.27292338
36Hypohidrosis (HP:0000966)3.17233743
37Hyporeflexia of lower limbs (HP:0002600)3.09391140
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.06825616
39Hemorrhage of the eye (HP:0011885)3.05187289
40Advanced eruption of teeth (HP:0006288)3.03119442
41Vasculitis (HP:0002633)3.02093089
42Acanthosis nigricans (HP:0000956)2.99554903
43Reticulocytopenia (HP:0001896)2.95614996
44Palmoplantar keratoderma (HP:0000982)2.94342991
45Abnormality of macrophages (HP:0004311)2.93292325
46Emphysema (HP:0002097)2.92774108
47Concave nail (HP:0001598)2.91551765
48Pustule (HP:0200039)2.90212284
49Thin bony cortex (HP:0002753)2.89073186
50Gangrene (HP:0100758)2.88356625
51Recurrent bacterial skin infections (HP:0005406)2.86897467
52Distal lower limb muscle weakness (HP:0009053)2.85886754
53Systemic lupus erythematosus (HP:0002725)2.84065031
54Meningitis (HP:0001287)2.82854949
55Panhypogammaglobulinemia (HP:0003139)2.82762424
56Pruritus (HP:0000989)2.82257318
57Agammaglobulinemia (HP:0004432)2.82023053
58Gastrointestinal infarctions (HP:0005244)2.81305020
59Abnormality of small intestinal villus morphology (HP:0011472)2.79875017
60Villous atrophy (HP:0011473)2.79875017
61Recurrent fungal infections (HP:0002841)2.79425363
62Abnormal hair laboratory examination (HP:0003328)2.77482112
63Hydroxyprolinuria (HP:0003080)2.73569193
64Abnormality of proline metabolism (HP:0010907)2.73569193
65Oligodontia (HP:0000677)2.72345520
66Myositis (HP:0100614)2.69080963
67Conjunctival hamartoma (HP:0100780)2.68067629
68Abnormality of the gastric mucosa (HP:0004295)2.67366921
69Gingivitis (HP:0000230)2.63086827
70Lymphopenia (HP:0001888)2.63075198
71Recurrent abscess formation (HP:0002722)2.58771236
72Abnormality of the salivary glands (HP:0010286)2.58017459
73Abnormality of secondary sexual hair (HP:0009888)2.57529592
74Abnormality of the axillary hair (HP:0100134)2.57529592
75Dehydration (HP:0001944)2.57453899
76Seborrheic dermatitis (HP:0001051)2.55782283
77Recurrent viral infections (HP:0004429)2.55488271
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.55003894
79Recurrent bronchitis (HP:0002837)2.54655536
80Abnormal hemoglobin (HP:0011902)2.52782177
81Flat acetabular roof (HP:0003180)2.49652076
82Verrucae (HP:0200043)2.46825813
83Papilloma (HP:0012740)2.46825813
84Cellulitis (HP:0100658)2.46629137
85Ridged nail (HP:0001807)2.45640198
86Ileus (HP:0002595)2.43153121
87Elevated erythrocyte sedimentation rate (HP:0003565)2.39401504
88Brittle hair (HP:0002299)2.39184177
89IgM deficiency (HP:0002850)2.35355900
90Hyperactive renin-angiotensin system (HP:0000841)2.35072151
91Biliary tract neoplasm (HP:0100574)2.34883558
92Mediastinal lymphadenopathy (HP:0100721)2.34427673
93Thick nail (HP:0001805)2.32988889
94Chronic obstructive pulmonary disease (HP:0006510)2.32704704
95Obstructive lung disease (HP:0006536)2.32704704
96Trismus (HP:0000211)2.31334367
97Areflexia of lower limbs (HP:0002522)2.28467975
98Orchitis (HP:0100796)2.28069286
99Abnormality of the fingertips (HP:0001211)2.27386056
100Broad face (HP:0000283)2.26702778
101Alopecia of scalp (HP:0002293)2.26260625
102Abnormality of T cells (HP:0002843)2.23765626
103Premature ovarian failure (HP:0008209)2.23765094
104Restrictive lung disease (HP:0002091)2.22814911
105Encephalitis (HP:0002383)2.22569139
106Abnormality of T cell physiology (HP:0011840)2.21883166
107Congenital, generalized hypertrichosis (HP:0004540)2.21632882
108Widely patent fontanelles and sutures (HP:0004492)2.21165121
109Hypoplastic labia majora (HP:0000059)2.20556622
110Popliteal pterygium (HP:0009756)2.19441948
111Dry skin (HP:0000958)2.18092317
112Segmental peripheral demyelination/remyelination (HP:0003481)2.17445319
113Blepharitis (HP:0000498)2.17232050
114Abdominal distention (HP:0003270)2.15875705
115Abnormal sex determination (HP:0012244)2.15709585
116Sex reversal (HP:0012245)2.15709585
117Gastrointestinal dysmotility (HP:0002579)2.14181425
118Abnormality of cells of the erythroid lineage (HP:0012130)2.11073598
119Pulmonary infiltrates (HP:0002113)2.09667811
120Hypophosphatemia (HP:0002148)2.09397493
121Spontaneous hematomas (HP:0007420)2.08633646
122Nasal polyposis (HP:0100582)2.07249530
123T lymphocytopenia (HP:0005403)2.06960142
124Recurrent skin infections (HP:0001581)2.06219337
125Abnormality of T cell number (HP:0011839)2.05165855
126Atrophic scars (HP:0001075)2.04260970
127Hypoplasia of dental enamel (HP:0006297)2.02846287
128Osteomyelitis (HP:0002754)2.02256371
129Recurrent sinusitis (HP:0011108)2.01090216
130Abnormality of the nasal mucosa (HP:0000433)2.00489479
131Skin ulcer (HP:0200042)1.99742065
132Macrocytic anemia (HP:0001972)1.99071602
133Prolonged bleeding time (HP:0003010)1.98560116
134Autoimmune hemolytic anemia (HP:0001890)1.97837354
135Abnormality of the labia majora (HP:0012881)1.97827209
136Urticaria (HP:0001025)1.97074307
137Pterygium (HP:0001059)1.96082435
138IgA deficiency (HP:0002720)1.93748504
139Prostate neoplasm (HP:0100787)1.92218076
140Chronic otitis media (HP:0000389)1.92011206
141Recurrent cutaneous fungal infections (HP:0011370)1.91430181
142Chronic mucocutaneous candidiasis (HP:0002728)1.91430181
143Esophageal atresia (HP:0002032)1.91014661
144Stenosis of the external auditory canal (HP:0000402)1.90269085
145Recurrent gram-negative bacterial infections (HP:0005420)1.90054150
146Chest pain (HP:0100749)1.89005595
147Abnormal biliary tract morphology (HP:0012440)1.88588431
148Decreased circulating renin level (HP:0003351)1.88226220
149Easy fatigability (HP:0003388)1.87706595
150Hemoptysis (HP:0002105)1.87536033
151Optic neuritis (HP:0100653)1.87519701
152Retrobulbar optic neuritis (HP:0100654)1.87519701
153Obstructive sleep apnea (HP:0002870)1.87433029
154Polygenic inheritance (HP:0010982)1.86968761
155Malnutrition (HP:0004395)1.86728090
156Joint swelling (HP:0001386)1.86178539
157Skin rash (HP:0000988)1.82376832
158Xanthomatosis (HP:0000991)1.82319048
159Glomerulonephritis (HP:0000099)1.82265016
160Granulocytopenia (HP:0001913)1.81038704
161Growth hormone excess (HP:0000845)1.80704319
162Breast hypoplasia (HP:0003187)1.77688272
163Dry hair (HP:0011359)1.73303902
164Aplasia cutis congenita (HP:0001057)1.72768022
165Abnormality of the preputium (HP:0100587)1.72427971
166Myopathic facies (HP:0002058)1.71412369
167Anhidrosis (HP:0000970)1.70046701
168Lack of skin elasticity (HP:0100679)1.68810789
169Hoarse voice (HP:0001609)1.65568369
170Anonychia (HP:0001798)1.64737020
171Congenital malformation of the right heart (HP:0011723)1.64083319
172Double outlet right ventricle (HP:0001719)1.64083319
173Skin pits (HP:0100276)1.63202979
174Down-sloping shoulders (HP:0200021)1.63058346
175Bifid scrotum (HP:0000048)1.61958355
176Abnormal number of erythroid precursors (HP:0012131)1.60740957
177Hypergammaglobulinemia (HP:0010702)1.60672401
178Pallor (HP:0000980)1.60070457
179Neonatal short-limb short stature (HP:0008921)1.58897474
180Ureteral duplication (HP:0000073)1.55643589
181Breech presentation (HP:0001623)1.53965999
182Epidermoid cyst (HP:0200040)1.53128437
183Premature loss of primary teeth (HP:0006323)1.52422583
184Angiofibromas (HP:0010615)1.49118718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.96390282
2MST1R5.50340702
3MAPKAPK34.96252348
4EPHB24.47826603
5MAP4K14.34565560
6RPS6KB23.15228628
7FER2.97458713
8EPHA22.96911947
9TRIB32.88878590
10SIK12.71312288
11PRPF4B2.70014930
12LATS12.65810662
13MAP3K22.55007833
14MAP3K102.40338046
15TYK22.32163294
16MAP3K32.16552341
17MET2.09713963
18GRK61.98394002
19SMG11.97063619
20BCR1.93315491
21LMTK21.85157360
22SIK31.82096010
23TTK1.79927679
24TRPM71.79733242
25MAP3K141.77996651
26MAP2K21.77763939
27EPHB11.59247837
28TAOK31.55084692
29CDC42BPA1.50793318
30IKBKE1.50758076
31ZAP701.50431452
32MAP3K131.50016709
33FGFR31.49672766
34STK101.45079358
35TBK11.44283906
36SIK21.42986866
37BTK1.42522607
38NME11.40648425
39EEF2K1.40530297
40IRAK41.38078835
41GRK11.32473516
42CSK1.31282074
43JAK11.29187307
44JAK31.22713498
45ITK1.19524084
46AURKB1.14344089
47TXK1.12981067
48LRRK21.12332073
49MAP2K61.10054609
50DYRK1B1.05634129
51CSF1R1.04918402
52TESK11.04005966
53PRKCI1.01755208
54AURKA0.96424814
55FRK0.93245191
56PRKD20.93235341
57PIK3CG0.93109028
58LCK0.92947262
59SYK0.91525987
60STK38L0.90099032
61ICK0.89850401
62PTK60.89517805
63MARK20.88134366
64PIM20.87983025
65HCK0.87736884
66ERBB30.87177012
67CDK60.86803415
68CDK70.83013704
69IKBKB0.80356457
70ACVR1B0.80012656
71LATS20.76780367
72TAOK10.76230177
73CDK120.76044572
74PKN20.74002176
75NME20.73985342
76HIPK20.73796118
77PDPK10.73350077
78PDK10.72212734
79SRPK10.72088635
80PBK0.71709205
81BMX0.71217236
82LYN0.69602869
83NEK20.68295841
84MAP3K80.67959707
85FES0.66328239
86PIK3CA0.66069090
87NUAK10.63557735
88TLK10.63064024
89ZAK0.62015086
90FGR0.61843430
91IRAK30.61453614
92NLK0.60350214
93TESK20.59828631
94CHUK0.59579708
95MAP3K10.59354455
96PASK0.58950735
97TYRO30.58819961
98MAPK150.57506391
99PRKG20.57407790
100MAP2K30.56599845
101KSR20.56019675
102JAK20.55283877
103MAP2K10.54598425
104ERBB20.53982275
105DYRK30.53031926
106MAPK70.52958628
107MAP3K70.52208003
108BRD40.52109475
109MAP3K60.51732559
110CDK40.51632059
111CSNK1D0.51313303
112STK240.51287844
113MAPKAPK50.51091230
114RET0.50794114
115PRKCQ0.50477490
116MAPKAPK20.49826975
117RPS6KA10.49325847
118ERBB40.49226717
119TNK20.49208271
120MELK0.48411903
121ERN10.47534420
122FYN0.47180010
123MATK0.45771375
124CHEK20.45751398
125MAP3K90.44798729
126RPS6KL10.44196836
127RPS6KC10.44196836
128YES10.44161258
129WEE10.43818773
130TEC0.43259145
131RIPK10.42988311
132MAP3K110.42822369
133CAMKK10.42198942
134MARK30.41462915
135IRAK10.40524442
136RPS6KA20.40231242
137FGFR10.39252836
138PDGFRA0.39057607
139CSNK1E0.38850526
140MAPK110.38618446
141TTN0.35857920
142NEK10.35643346
143PLK10.35496057
144CDK190.34057467
145STK30.33774689
146BLK0.33380529
147OBSCN0.31762249
148FGFR40.29899267
149LIMK10.27534040
150PTK20.27458744
151CDK30.26675135
152EPHA30.26504694
153EIF2AK20.24872948
154PDK20.24448727
155ALK0.24421025
156ATM0.23894563
157PRKD10.23522417
158AKT30.21752698
159RIPK40.20479374
160CSNK2A20.20376628
161PAK30.20129299
162RPS6KA40.19237335
163PRKCA0.19053744

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.25734512
2Cyanoamino acid metabolism_Homo sapiens_hsa004604.20414798
3Sphingolipid metabolism_Homo sapiens_hsa006003.89366360
4Linoleic acid metabolism_Homo sapiens_hsa005913.50771082
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.40629985
6Fat digestion and absorption_Homo sapiens_hsa049753.30712801
7Mineral absorption_Homo sapiens_hsa049783.29116453
8Arachidonic acid metabolism_Homo sapiens_hsa005902.73452780
9Allograft rejection_Homo sapiens_hsa053302.67299686
10Primary immunodeficiency_Homo sapiens_hsa053402.66924122
11Autoimmune thyroid disease_Homo sapiens_hsa053202.56212230
12Graft-versus-host disease_Homo sapiens_hsa053322.48550607
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.39163503
14Tight junction_Homo sapiens_hsa045302.35021155
15Other glycan degradation_Homo sapiens_hsa005112.20455350
16Histidine metabolism_Homo sapiens_hsa003402.01729959
17Vitamin digestion and absorption_Homo sapiens_hsa049772.01642137
18Asthma_Homo sapiens_hsa053101.95021896
19Folate biosynthesis_Homo sapiens_hsa007901.93244973
20Type I diabetes mellitus_Homo sapiens_hsa049401.90429494
21Staphylococcus aureus infection_Homo sapiens_hsa051501.83075624
22p53 signaling pathway_Homo sapiens_hsa041151.81501244
23B cell receptor signaling pathway_Homo sapiens_hsa046621.80820664
24Leishmaniasis_Homo sapiens_hsa051401.79814086
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.79573743
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.76347783
27Ether lipid metabolism_Homo sapiens_hsa005651.66706754
28T cell receptor signaling pathway_Homo sapiens_hsa046601.64875017
29Adherens junction_Homo sapiens_hsa045201.63485168
30Antigen processing and presentation_Homo sapiens_hsa046121.62920194
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61613125
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.57820369
33Basal cell carcinoma_Homo sapiens_hsa052171.52337390
34Glutathione metabolism_Homo sapiens_hsa004801.45473752
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44415301
36Viral myocarditis_Homo sapiens_hsa054161.43644620
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39925740
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37754605
39Bladder cancer_Homo sapiens_hsa052191.37414772
40Protein digestion and absorption_Homo sapiens_hsa049741.34747929
41Fatty acid elongation_Homo sapiens_hsa000621.34162806
42Osteoclast differentiation_Homo sapiens_hsa043801.34159407
43Toxoplasmosis_Homo sapiens_hsa051451.34093745
44ABC transporters_Homo sapiens_hsa020101.32474549
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31338668
46Acute myeloid leukemia_Homo sapiens_hsa052211.31205000
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.29983062
48Hippo signaling pathway_Homo sapiens_hsa043901.28767859
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24751734
50Retinol metabolism_Homo sapiens_hsa008301.24368301
51Herpes simplex infection_Homo sapiens_hsa051681.22983829
52Renin-angiotensin system_Homo sapiens_hsa046141.22695955
53Influenza A_Homo sapiens_hsa051641.21759244
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19539944
55Hematopoietic cell lineage_Homo sapiens_hsa046401.17140411
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14884410
57RNA polymerase_Homo sapiens_hsa030201.13345790
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12529914
59Sulfur metabolism_Homo sapiens_hsa009201.12291510
60Phenylalanine metabolism_Homo sapiens_hsa003601.11969745
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.11344056
62TNF signaling pathway_Homo sapiens_hsa046681.09596577
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08796237
64Measles_Homo sapiens_hsa051621.07226159
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06855976
66Thyroid cancer_Homo sapiens_hsa052161.04908901
67Phototransduction_Homo sapiens_hsa047441.03181028
68Arginine biosynthesis_Homo sapiens_hsa002201.03128834
69Notch signaling pathway_Homo sapiens_hsa043300.96910851
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96417806
71Tuberculosis_Homo sapiens_hsa051520.96369521
72TGF-beta signaling pathway_Homo sapiens_hsa043500.96162454
73Chemical carcinogenesis_Homo sapiens_hsa052040.96074198
74Chemokine signaling pathway_Homo sapiens_hsa040620.94905546
75Glycerolipid metabolism_Homo sapiens_hsa005610.93082997
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90450559
77Pancreatic secretion_Homo sapiens_hsa049720.89743220
78Mismatch repair_Homo sapiens_hsa034300.88914047
79Insulin resistance_Homo sapiens_hsa049310.87669400
80Hepatitis C_Homo sapiens_hsa051600.86066017
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84036469
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81653865
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78339050
84Starch and sucrose metabolism_Homo sapiens_hsa005000.78009968
85Hedgehog signaling pathway_Homo sapiens_hsa043400.77429347
86Choline metabolism in cancer_Homo sapiens_hsa052310.77048172
87Fructose and mannose metabolism_Homo sapiens_hsa000510.76217393
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.72022651
89Non-small cell lung cancer_Homo sapiens_hsa052230.71808505
90MicroRNAs in cancer_Homo sapiens_hsa052060.71589652
91Melanogenesis_Homo sapiens_hsa049160.71139883
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.70854249
93GnRH signaling pathway_Homo sapiens_hsa049120.69625350
94VEGF signaling pathway_Homo sapiens_hsa043700.69297093
95Hepatitis B_Homo sapiens_hsa051610.67925629
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.67118214
97Chronic myeloid leukemia_Homo sapiens_hsa052200.66175828
98Apoptosis_Homo sapiens_hsa042100.65024753
99Fatty acid biosynthesis_Homo sapiens_hsa000610.65000162
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62883932
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.60435558
102Inositol phosphate metabolism_Homo sapiens_hsa005620.59348809
103Axon guidance_Homo sapiens_hsa043600.59047267
104Bile secretion_Homo sapiens_hsa049760.55211245
105Pancreatic cancer_Homo sapiens_hsa052120.54764873
106Epstein-Barr virus infection_Homo sapiens_hsa051690.54237768
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53738298
108Prolactin signaling pathway_Homo sapiens_hsa049170.53210827
109Phospholipase D signaling pathway_Homo sapiens_hsa040720.51816387
110ECM-receptor interaction_Homo sapiens_hsa045120.51545978
111Tryptophan metabolism_Homo sapiens_hsa003800.51280481
112HTLV-I infection_Homo sapiens_hsa051660.50357613
113Platelet activation_Homo sapiens_hsa046110.49894618
114Pertussis_Homo sapiens_hsa051330.49757646
115Proteoglycans in cancer_Homo sapiens_hsa052050.49520910
116African trypanosomiasis_Homo sapiens_hsa051430.49430195
117Caffeine metabolism_Homo sapiens_hsa002320.48088650
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46488632
119Gastric acid secretion_Homo sapiens_hsa049710.45536975
120Collecting duct acid secretion_Homo sapiens_hsa049660.44446379
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43958984
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43692606
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43656293
124Wnt signaling pathway_Homo sapiens_hsa043100.43378910
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.43337126
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42103024
127Tyrosine metabolism_Homo sapiens_hsa003500.41279234
128Endocytosis_Homo sapiens_hsa041440.40558253
129Galactose metabolism_Homo sapiens_hsa000520.39851855
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37980490
131DNA replication_Homo sapiens_hsa030300.37935200
132RNA transport_Homo sapiens_hsa030130.37694915
133Viral carcinogenesis_Homo sapiens_hsa052030.37387196
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37100233
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36822765
136Shigellosis_Homo sapiens_hsa051310.36504591
137Proteasome_Homo sapiens_hsa030500.35250986
138mTOR signaling pathway_Homo sapiens_hsa041500.34575253
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34014816
140beta-Alanine metabolism_Homo sapiens_hsa004100.30808144
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29815250
142Fatty acid degradation_Homo sapiens_hsa000710.29592737
143Dorso-ventral axis formation_Homo sapiens_hsa043200.29381864
144PPAR signaling pathway_Homo sapiens_hsa033200.28716887
145Pyrimidine metabolism_Homo sapiens_hsa002400.27811919
146Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26747889
147Small cell lung cancer_Homo sapiens_hsa052220.24660889
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.23747694
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23502372
150Vibrio cholerae infection_Homo sapiens_hsa051100.23169742
151Ras signaling pathway_Homo sapiens_hsa040140.21685382
152Fanconi anemia pathway_Homo sapiens_hsa034600.21499907
153Cell cycle_Homo sapiens_hsa041100.20970680
154ErbB signaling pathway_Homo sapiens_hsa040120.19935331
155Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19203449
156Metabolic pathways_Homo sapiens_hsa011000.18860650
157Estrogen signaling pathway_Homo sapiens_hsa049150.18252391
158Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17324822
159Homologous recombination_Homo sapiens_hsa034400.17271053
160Endometrial cancer_Homo sapiens_hsa052130.16580991
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.15559310
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14974733

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