ANO5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)9.42148858
2skeletal muscle fiber development (GO:0048741)9.29261253
3plasma membrane repair (GO:0001778)8.63869344
4skeletal muscle adaptation (GO:0043501)8.25649233
5myotube cell development (GO:0014904)8.03830857
6actin filament-based movement (GO:0030048)7.80055080
7response to stimulus involved in regulation of muscle adaptation (GO:0014874)7.09633281
8response to inactivity (GO:0014854)6.74602317
9striated muscle contraction (GO:0006941)6.62632022
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.60806067
11sarcomere organization (GO:0045214)6.49587148
12striated muscle atrophy (GO:0014891)6.44551616
13response to muscle activity (GO:0014850)5.87002205
14regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.75601536
15glycogen catabolic process (GO:0005980)5.66953595
16skeletal muscle tissue regeneration (GO:0043403)5.59482481
17muscle atrophy (GO:0014889)5.59019009
18regulation of cell communication by electrical coupling (GO:0010649)5.56614358
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.56239703
20muscle contraction (GO:0006936)5.52458530
21myofibril assembly (GO:0030239)5.46296544
22muscle fiber development (GO:0048747)5.46281613
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.40351257
24positive regulation of myotube differentiation (GO:0010831)5.34920841
25glucan catabolic process (GO:0009251)5.29962137
26muscle cell fate commitment (GO:0042693)5.18409313
27striated muscle adaptation (GO:0014888)5.17225512
28muscle cell cellular homeostasis (GO:0046716)5.02406779
29muscle system process (GO:0003012)4.94689553
30cellular polysaccharide catabolic process (GO:0044247)4.90128729
31myoblast fusion (GO:0007520)4.84010306
32carnitine shuttle (GO:0006853)4.79130161
33creatine metabolic process (GO:0006600)4.74216648
34regulation of hexokinase activity (GO:1903299)4.73083788
35regulation of glucokinase activity (GO:0033131)4.73083788
36polysaccharide catabolic process (GO:0000272)4.66396193
37actomyosin structure organization (GO:0031032)4.58797626
38myotube differentiation (GO:0014902)4.55377789
39neuromuscular synaptic transmission (GO:0007274)4.54766210
40glycogen biosynthetic process (GO:0005978)4.53680877
41glucan biosynthetic process (GO:0009250)4.53680877
42pyrimidine ribonucleoside catabolic process (GO:0046133)4.51372627
43muscle organ development (GO:0007517)4.48987077
44positive regulation of myoblast differentiation (GO:0045663)4.45840903
45muscle structure development (GO:0061061)4.41936762
46purine nucleotide salvage (GO:0032261)4.41056246
47syncytium formation by plasma membrane fusion (GO:0000768)4.34751063
48negative regulation of potassium ion transmembrane transport (GO:1901380)4.34170295
49positive regulation of glycolytic process (GO:0045821)4.30451430
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.28887020
51skeletal muscle tissue development (GO:0007519)4.27973353
52syncytium formation (GO:0006949)4.26924564
53regulation of skeletal muscle cell differentiation (GO:2001014)4.15638095
54muscle adaptation (GO:0043500)4.12557645
55neuronal action potential propagation (GO:0019227)4.11921701
56detection of calcium ion (GO:0005513)4.08510576
57cytidine metabolic process (GO:0046087)4.08110981
58cytidine catabolic process (GO:0006216)4.08110981
59cytidine deamination (GO:0009972)4.08110981
60striated muscle cell development (GO:0055002)4.07738139
61regulation of acyl-CoA biosynthetic process (GO:0050812)3.98040691
62fatty acid transmembrane transport (GO:1902001)3.93183657
63negative regulation of muscle hypertrophy (GO:0014741)3.92630554
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.91394625
65neuromuscular junction development (GO:0007528)3.87974190
66positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.87929353
67glycogen metabolic process (GO:0005977)3.87691871
68regulation of relaxation of muscle (GO:1901077)3.83675169
69cellular glucan metabolic process (GO:0006073)3.79663423
70glucan metabolic process (GO:0044042)3.79663423
71cardiac muscle contraction (GO:0060048)3.78598773
72fatty acid homeostasis (GO:0055089)3.77963704
73IMP metabolic process (GO:0046040)3.74491677
74chemosensory behavior (GO:0007635)3.71579955
75cellular ketone body metabolic process (GO:0046950)3.69710931
76regulation of calcium ion transmembrane transport (GO:1903169)3.66256248
77regulation of calcium ion transmembrane transporter activity (GO:1901019)3.66256248
78regulation of type B pancreatic cell apoptotic process (GO:2000674)3.62796287
79carnitine transmembrane transport (GO:1902603)3.60343643
80regulation of cofactor metabolic process (GO:0051193)3.58653998
81regulation of coenzyme metabolic process (GO:0051196)3.58653998
82muscle cell development (GO:0055001)3.53362796
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52888466
84cardiac muscle hypertrophy (GO:0003300)3.48256377
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.46683480
86response to activity (GO:0014823)3.45691530
87negative regulation of cytosolic calcium ion concentration (GO:0051481)3.44889067
88regulation of striated muscle contraction (GO:0006942)3.37897241
89regulation of actin filament-based movement (GO:1903115)3.36906522
90negative regulation of hormone biosynthetic process (GO:0032353)3.36823920
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.36807987
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.35848541
93regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.33727403
94presynaptic membrane assembly (GO:0097105)3.30760510
95inositol phosphate catabolic process (GO:0071545)3.30641071
96striated muscle hypertrophy (GO:0014897)3.29924908
97amino-acid betaine transport (GO:0015838)3.28999152
98carnitine transport (GO:0015879)3.28999152
99cardiac myofibril assembly (GO:0055003)3.28634158
100ketone body metabolic process (GO:1902224)3.27399151
101regulation of myoblast differentiation (GO:0045661)3.27139026
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.24237622
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.24209166
104tricarboxylic acid cycle (GO:0006099)3.23693938
105lactate metabolic process (GO:0006089)3.22893458
106regulation of sarcomere organization (GO:0060297)3.19374447
107positive regulation of skeletal muscle tissue development (GO:0048643)3.17151020
108nitric oxide mediated signal transduction (GO:0007263)3.16036269
109cellular carbohydrate catabolic process (GO:0044275)3.15774498
110negative regulation of heart rate (GO:0010459)3.10941529
111regulation of membrane repolarization (GO:0060306)3.10781649
112negative regulation of skeletal muscle tissue development (GO:0048642)3.08747544
113dendritic spine morphogenesis (GO:0060997)3.05226238
114regulation of myotube differentiation (GO:0010830)3.01890990
115negative regulation of protein localization to cell surface (GO:2000009)2.99965613
116phosphorylated carbohydrate dephosphorylation (GO:0046838)2.98352894
117inositol phosphate dephosphorylation (GO:0046855)2.98352894
118adult heart development (GO:0007512)2.96487174
119regulation of action potential (GO:0098900)2.94567392
120regulation of sulfur metabolic process (GO:0042762)2.92725822
121polyol catabolic process (GO:0046174)2.92018661
122nucleoside diphosphate catabolic process (GO:0009134)2.91953694
123relaxation of muscle (GO:0090075)2.88666857
124calcium ion import (GO:0070509)2.88339895
125water-soluble vitamin biosynthetic process (GO:0042364)2.87016386
126negative regulation of cell size (GO:0045792)2.85985769
127striated muscle tissue development (GO:0014706)2.84632338
128positive regulation of protein autophosphorylation (GO:0031954)2.83413063
129prostate gland growth (GO:0060736)2.82590165
130muscle hypertrophy (GO:0014896)2.80962125
131negative regulation of hormone metabolic process (GO:0032351)2.80741579
132insulin secretion (GO:0030073)2.75012590
133positive regulation of glycogen biosynthetic process (GO:0045725)2.72212344
134relaxation of cardiac muscle (GO:0055119)2.71769616
135endocrine pancreas development (GO:0031018)2.71659126
136presynaptic membrane organization (GO:0097090)2.71353796
137cardiac muscle cell development (GO:0055013)2.70933737
138regulation of energy homeostasis (GO:2000505)2.66945578
139protein targeting to Golgi (GO:0000042)2.64386268
140establishment of protein localization to Golgi (GO:0072600)2.59400959
141negative regulation of potassium ion transport (GO:0043267)2.58377300
142negative regulation of protein oligomerization (GO:0032460)2.56926121
143righting reflex (GO:0060013)2.55206763
144cardiac muscle cell action potential (GO:0086001)2.52734948
145negative regulation of calcium ion transmembrane transport (GO:1903170)2.52232846
146negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52232846
147negative regulation of acute inflammatory response (GO:0002674)2.51683780
148somite rostral/caudal axis specification (GO:0032525)2.47089603
149retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46900631
150tachykinin receptor signaling pathway (GO:0007217)2.46823076
151positive regulation of peptide hormone secretion (GO:0090277)2.46170953
152positive regulation of action potential (GO:0045760)2.45364554
153cardiac muscle tissue morphogenesis (GO:0055008)2.43108786
154dentate gyrus development (GO:0021542)2.40996942
155muscle filament sliding (GO:0030049)12.6108634
156actin-myosin filament sliding (GO:0033275)12.6108634
157skeletal muscle contraction (GO:0003009)11.6282545
158regulation of skeletal muscle contraction (GO:0014819)11.5149579
159actin-mediated cell contraction (GO:0070252)10.4593246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.11125822
2EZH2_22144423_ChIP-Seq_EOC_Human4.27681815
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.05127164
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.80012386
5ESR1_20079471_ChIP-ChIP_T-47D_Human3.47717011
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86320056
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70391260
8IGF1R_20145208_ChIP-Seq_DFB_Human2.68306621
9ZNF274_21170338_ChIP-Seq_K562_Hela2.49144658
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.43260352
11FUS_26573619_Chip-Seq_HEK293_Human2.40079205
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38519719
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38230768
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.30224550
15TAF15_26573619_Chip-Seq_HEK293_Human2.28572596
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16752314
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.16326762
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14758174
19VDR_22108803_ChIP-Seq_LS180_Human2.08327583
20P300_19829295_ChIP-Seq_ESCs_Human2.07109077
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01408902
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94858588
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.94778055
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.94778055
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94108077
26AR_21572438_ChIP-Seq_LNCaP_Human1.90149452
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89526043
28SMAD4_21799915_ChIP-Seq_A2780_Human1.86750911
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84300957
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82494208
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.81121462
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80859234
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79560430
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76312730
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.75235069
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.74774655
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.72525227
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71668862
39EWS_26573619_Chip-Seq_HEK293_Human1.70477234
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70171181
41BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.65627520
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65463966
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65235168
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.64192031
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.63243740
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62847440
47OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60287498
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60130500
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60130500
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59744982
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59536843
52DROSHA_22980978_ChIP-Seq_HELA_Human1.56888622
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.56024758
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.55953611
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.54271837
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52884343
57* STAT3_23295773_ChIP-Seq_U87_Human1.52644042
58CTCF_27219007_Chip-Seq_Bcells_Human1.51683951
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51178556
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49502216
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49050383
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48701130
63* TCF4_23295773_ChIP-Seq_U87_Human1.47806071
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46277317
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43004140
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41486276
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40777284
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39336394
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.39225146
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39163561
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38429017
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.35758444
73* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35346730
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.32838519
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32674125
76CBP_20019798_ChIP-Seq_JUKART_Human1.32417623
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32417623
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31901349
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30462093
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30150454
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.29932657
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28641963
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27789531
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27735963
85JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26417813
86HTT_18923047_ChIP-ChIP_STHdh_Human1.25947495
87P53_22387025_ChIP-Seq_ESCs_Mouse1.25778961
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25681082
89EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24511142
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23911831
91* NANOG_19829295_ChIP-Seq_ESCs_Human1.23546303
92* SOX2_19829295_ChIP-Seq_ESCs_Human1.23546303
93TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.23305226
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.21385587
95REST_21632747_ChIP-Seq_MESCs_Mouse1.20532965
96ZNF263_19887448_ChIP-Seq_K562_Human1.19624321
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17427221
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16977151
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.16530729
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16212576
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15795973
102TCF4_22108803_ChIP-Seq_LS180_Human1.15668512
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.14202168
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14092914
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14028678
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13111140
107TDRD3_21172665_ChIP-Seq_MCF-7_Human1.12657893
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12499131
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11974834
110TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11849605
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.11370277
112RARB_27405468_Chip-Seq_BRAIN_Mouse1.11100510
113RUNX2_22187159_ChIP-Seq_PCA_Human1.10834225
114RNF2_27304074_Chip-Seq_NSC_Mouse1.10750480
115P300_18555785_Chip-Seq_ESCs_Mouse1.09216445
116CDX2_22108803_ChIP-Seq_LS180_Human1.09136544
117LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08008465
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.07924222
119EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.07879180
120CJUN_26792858_Chip-Seq_BT549_Human1.07846274
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07548688
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07031789
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.07000130
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.06750163
125FOXH1_21741376_ChIP-Seq_ESCs_Human1.06520189
126ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06344735
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06065981
128TAL1_26923725_Chip-Seq_HPCs_Mouse1.05224397
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.03973638
130SMC3_22415368_ChIP-Seq_MEFs_Mouse1.03859047
131SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02766594
132SMAD3_21741376_ChIP-Seq_HESCs_Human1.02284335
133* CBX2_27304074_Chip-Seq_ESCs_Mouse1.01279575
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01047978
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00690686
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00584377
137ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00398460
138* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99170044
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.98665462
140NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96797350
141NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96797350
142SA1_27219007_Chip-Seq_Bcells_Human0.96285998
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95394157
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95245008
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92436741
146GBX2_23144817_ChIP-Seq_PC3_Human0.91450086
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.91161570
148GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91153625
149PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91100974
150CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90090750
151BCAT_22108803_ChIP-Seq_LS180_Human0.88681976
152NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88613216
153KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87739166
154TP53_18474530_ChIP-ChIP_U2OS_Human0.87286646
155TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86955235
156SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85667027
157KLF4_19829295_ChIP-Seq_ESCs_Human0.84602866
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.83692834
159ER_23166858_ChIP-Seq_MCF-7_Human0.82875928
160AR_19668381_ChIP-Seq_PC3_Human0.82581053
161HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81847732
162MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81149761
163AR_25329375_ChIP-Seq_VCAP_Human0.80697989
164SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80046503
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.79811139
166WT1_19549856_ChIP-ChIP_CCG9911_Human0.79175933
167LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.77891215
168* OCT4_20526341_ChIP-Seq_ESCs_Human0.77575692
169SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77524290
170CREB1_26743006_Chip-Seq_LNCaP_Human0.76808031
171EED_16625203_ChIP-ChIP_MESCs_Mouse0.75250469
172P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74902400
173TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.74895579
174GATA4_21415370_ChIP-Seq_HL-1_Mouse0.74360283
175KDM2B_26808549_Chip-Seq_K562_Human0.74308824
176UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74031468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio7.59530507
2MP0000749_muscle_degeneration6.61138940
3MP0000751_myopathy6.04666752
4MP0003646_muscle_fatigue5.46848144
5MP0000747_muscle_weakness4.55199541
6MP0002106_abnormal_muscle_physiology4.23697646
7MP0000750_abnormal_muscle_regeneration4.05951414
8MP0000759_abnormal_skeletal_muscle3.91256083
9MP0004036_abnormal_muscle_relaxation3.73910419
10MP0002837_dystrophic_cardiac_calcinosis3.59056777
11MP0005369_muscle_phenotype3.53353315
12MP0002269_muscular_atrophy3.44384108
13MP0004087_abnormal_muscle_fiber3.38110298
14MP0000733_abnormal_muscle_development3.11880444
15MP0005620_abnormal_muscle_contractility2.93868717
16MP0003195_calcinosis2.87222437
17MP0004233_abnormal_muscle_weight2.81541161
18MP0004270_analgesia2.77328865
19MP0004130_abnormal_muscle_cell2.76645651
20MP0002108_abnormal_muscle_morphology2.26830505
21MP0003283_abnormal_digestive_organ2.17943039
22MP0010234_abnormal_vibrissa_follicle2.17087297
23MP0002332_abnormal_exercise_endurance1.99722770
24MP0001984_abnormal_olfaction1.98515305
25MP0005330_cardiomyopathy1.81483859
26MP0002102_abnormal_ear_morphology1.81383525
27MP0004084_abnormal_cardiac_muscle1.77858580
28MP0003787_abnormal_imprinting1.77531043
29MP0006072_abnormal_retinal_apoptosis1.64285146
30MP0003950_abnormal_plasma_membrane1.62134862
31MP0010386_abnormal_urinary_bladder1.57882414
32MP0006036_abnormal_mitochondrial_physio1.55859370
33MP0008877_abnormal_DNA_methylation1.51558604
34MP0004215_abnormal_myocardial_fiber1.46282849
35MP0002971_abnormal_brown_adipose1.44733609
36MP0009745_abnormal_behavioral_response1.38626475
37MP0003122_maternal_imprinting1.36500110
38MP0005646_abnormal_pituitary_gland1.35758405
39MP0002822_catalepsy1.35671049
40MP0002638_abnormal_pupillary_reflex1.33263598
41MP0002909_abnormal_adrenal_gland1.32893960
42MP0001661_extended_life_span1.28801427
43MP0002272_abnormal_nervous_system1.27489347
44MP0002972_abnormal_cardiac_muscle1.25735866
45MP0002163_abnormal_gland_morphology1.23054368
46MP0005379_endocrine/exocrine_gland_phen1.19577763
47MP0003123_paternal_imprinting1.18338520
48MP0004484_altered_response_of1.17714897
49MP0001299_abnormal_eye_distance/1.15544938
50MP0001944_abnormal_pancreas_morphology1.15441377
51MP0002254_reproductive_system_inflammat1.15110870
52MP0002234_abnormal_pharynx_morphology1.14266100
53MP0004185_abnormal_adipocyte_glucose1.11121305
54MP0002064_seizures1.10931550
55MP0010630_abnormal_cardiac_muscle1.08848359
56MP0004924_abnormal_behavior1.07550927
57MP0005386_behavior/neurological_phenoty1.07550927
58MP0002693_abnormal_pancreas_physiology1.07048622
59MP0001486_abnormal_startle_reflex1.03547414
60MP0005253_abnormal_eye_physiology1.02227612
61MP0000427_abnormal_hair_cycle1.01891219
62MP0003121_genomic_imprinting1.01288186
63MP0001529_abnormal_vocalization1.00663486
64MP0003880_abnormal_central_pattern1.00426137
65MP0005551_abnormal_eye_electrophysiolog0.99975878
66MP0002876_abnormal_thyroid_physiology0.99893813
67MP0001485_abnormal_pinna_reflex0.99687196
68MP0005266_abnormal_metabolism0.98228980
69MP0004885_abnormal_endolymph0.97649543
70MP0005645_abnormal_hypothalamus_physiol0.97608271
71MP0009250_abnormal_appendicular_skeleto0.95815993
72MP0003890_abnormal_embryonic-extraembry0.95567638
73MP0005666_abnormal_adipose_tissue0.94684290
74MP0002160_abnormal_reproductive_system0.93938192
75MP0000569_abnormal_digit_pigmentation0.93788005
76MP0005220_abnormal_exocrine_pancreas0.93565335
77MP0000631_abnormal_neuroendocrine_gland0.91158700
78MP0003633_abnormal_nervous_system0.90258271
79MP0000013_abnormal_adipose_tissue0.90213017
80MP0002928_abnormal_bile_duct0.87556578
81MP0010678_abnormal_skin_adnexa0.86518232
82MP0002572_abnormal_emotion/affect_behav0.84437877
83MP0009780_abnormal_chondrocyte_physiolo0.83414504
84MP0005332_abnormal_amino_acid0.83404632
85MP0003221_abnormal_cardiomyocyte_apopto0.82847995
86MP0005187_abnormal_penis_morphology0.82464983
87MP0002090_abnormal_vision0.82351095
88MP0003137_abnormal_impulse_conducting0.81733255
89MP0006276_abnormal_autonomic_nervous0.80757364
90MP0004133_heterotaxia0.80726446
91MP0006035_abnormal_mitochondrial_morpho0.80233074
92MP0004134_abnormal_chest_morphology0.77679610
93MP0000372_irregular_coat_pigmentation0.77301585
94MP0004043_abnormal_pH_regulation0.75940033
95MP0001756_abnormal_urination0.75887941
96MP0005375_adipose_tissue_phenotype0.74054134
97MP0002734_abnormal_mechanical_nocicepti0.73368782
98MP0001501_abnormal_sleep_pattern0.72987630
99MP0005535_abnormal_body_temperature0.71811891
100MP0005385_cardiovascular_system_phenoty0.71697770
101MP0001544_abnormal_cardiovascular_syste0.71697770
102MP0005623_abnormal_meninges_morphology0.65418076
103MP0000762_abnormal_tongue_morphology0.62653194
104MP0008961_abnormal_basal_metabolism0.61866551
105MP0003959_abnormal_lean_body0.60467471
106MP0008569_lethality_at_weaning0.56915484
107MP0003806_abnormal_nucleotide_metabolis0.56531828
108MP0002114_abnormal_axial_skeleton0.54694901
109MP0002896_abnormal_bone_mineralization0.51778509
110MP0003705_abnormal_hypodermis_morpholog0.49649394
111MP0002078_abnormal_glucose_homeostasis0.47538923
112MP0005452_abnormal_adipose_tissue0.47503257
113MP0005275_abnormal_skin_tensile0.47190505
114MP0005334_abnormal_fat_pad0.46289300
115MP0004147_increased_porphyrin_level0.45305679
116MP0001943_abnormal_respiration0.44959082
117MP0000266_abnormal_heart_morphology0.44182970
118MP0003948_abnormal_gas_homeostasis0.44135012
119MP0000003_abnormal_adipose_tissue0.43794367
120MP0008775_abnormal_heart_ventricle0.41706846
121MP0003045_fibrosis0.41588416
122MP0002089_abnormal_postnatal_growth/wei0.41211995
123MP0006138_congestive_heart_failure0.41139720
124MP0004859_abnormal_synaptic_plasticity0.40903767
125MP0003879_abnormal_hair_cell0.40619871
126MP0005503_abnormal_tendon_morphology0.39760036
127MP0002127_abnormal_cardiovascular_syste0.39546283
128MP0004142_abnormal_muscle_tone0.39427469
129MP0003656_abnormal_erythrocyte_physiolo0.39067518
130MP0002066_abnormal_motor_capabilities/c0.38534654
131MP0001440_abnormal_grooming_behavior0.36982571
132MP0003385_abnormal_body_wall0.36107463
133MP0010030_abnormal_orbit_morphology0.35700498
134MP0004085_abnormal_heartbeat0.34694533
135MP0003755_abnormal_palate_morphology0.34596068
136MP0002067_abnormal_sensory_capabilities0.32983876
137MP0002184_abnormal_innervation0.32033036
138MP0001542_abnormal_bone_strength0.30782167
139MP0002932_abnormal_joint_morphology0.30135526
140MP0003635_abnormal_synaptic_transmissio0.28383167
141MP0009115_abnormal_fat_cell0.28044934
142MP0002249_abnormal_larynx_morphology0.27022797
143MP0000955_abnormal_spinal_cord0.26713482
144MP0008438_abnormal_cutaneous_collagen0.26559761
145MP0005584_abnormal_enzyme/coenzyme_acti0.25894228
146MP0004510_myositis0.25642812
147MP0000383_abnormal_hair_follicle0.24528770
148MP0009046_muscle_twitch0.22839893
149MP0002081_perinatal_lethality0.19656229
150MP0009672_abnormal_birth_weight0.19595635
151MP0003828_pulmonary_edema0.19351146
152MP0001849_ear_inflammation0.19207114
153MP0000678_abnormal_parathyroid_gland0.18833224
154MP0005376_homeostasis/metabolism_phenot0.18701340

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.83410319
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.63928905
3Nemaline bodies (HP:0003798)8.88731379
4Exercise-induced myalgia (HP:0003738)7.92616333
5Distal arthrogryposis (HP:0005684)7.80150302
6Type 1 muscle fiber predominance (HP:0003803)7.28401934
7Exercise-induced muscle cramps (HP:0003710)7.06441553
8Round ear (HP:0100830)6.62469817
9Ulnar deviation of the wrist (HP:0003049)6.40008167
10Myopathic facies (HP:0002058)6.32617703
11Calcaneovalgus deformity (HP:0001848)5.63231286
12* Muscle hypertrophy of the lower extremities (HP:0008968)5.58827222
13Muscle fiber splitting (HP:0003555)5.30162753
14Absent phalangeal crease (HP:0006109)5.15157876
15Deformed tarsal bones (HP:0008119)5.04971797
16Malignant hyperthermia (HP:0002047)4.88486072
17* Calf muscle hypertrophy (HP:0008981)4.80133713
18Hyperinsulinemic hypoglycemia (HP:0000825)4.71264626
19Hyporeflexia of lower limbs (HP:0002600)4.58008287
20* Difficulty running (HP:0009046)4.45284780
21Hypoglycemic seizures (HP:0002173)4.39118023
22Abnormal finger flexion creases (HP:0006143)4.35026799
23Myoglobinuria (HP:0002913)4.30487737
24Increased connective tissue (HP:0009025)4.23702377
25Muscle stiffness (HP:0003552)4.20517514
26Hypoglycemic coma (HP:0001325)4.11374639
27Fetal akinesia sequence (HP:0001989)4.10374525
28* EMG: myopathic abnormalities (HP:0003458)4.06319541
29Myotonia (HP:0002486)4.01256895
30* Abnormality of the calf musculature (HP:0001430)4.00114361
31Hyperglycemia (HP:0003074)3.94608833
32Abnormality of the neuromuscular junction (HP:0003398)3.92325187
33Fatigable weakness (HP:0003473)3.92325187
34Abnormality of skeletal muscle fiber size (HP:0012084)3.78483622
35Ketoacidosis (HP:0001993)3.77236418
36Rhabdomyolysis (HP:0003201)3.50112225
37Neck muscle weakness (HP:0000467)3.50082044
38Abnormality of endocrine pancreas physiology (HP:0012093)3.47986036
39Abnormality of the pancreatic islet cells (HP:0006476)3.47986036
40Abnormality of the calcaneus (HP:0008364)3.39401498
41Increased variability in muscle fiber diameter (HP:0003557)3.35162049
42Bundle branch block (HP:0011710)3.31944400
43Abnormality of the left ventricular outflow tract (HP:0011103)3.16529462
44Subaortic stenosis (HP:0001682)3.16529462
45Type 2 muscle fiber atrophy (HP:0003554)3.12917677
46Weak cry (HP:0001612)3.10697705
47* Difficulty climbing stairs (HP:0003551)3.07582560
48Gowers sign (HP:0003391)3.05338480
49Bulbar palsy (HP:0001283)2.99492310
50Frequent falls (HP:0002359)2.94617649
51Rimmed vacuoles (HP:0003805)2.90804171
52Insulin-resistant diabetes mellitus (HP:0000831)2.82864317
53Mildly elevated creatine phosphokinase (HP:0008180)2.80899523
54Muscle fiber atrophy (HP:0100295)2.80322087
55Popliteal pterygium (HP:0009756)2.79332323
56Large for gestational age (HP:0001520)2.77225223
57Pancreatic islet-cell hyperplasia (HP:0004510)2.74733774
58Areflexia of lower limbs (HP:0002522)2.74628377
59Symptomatic seizures (HP:0011145)2.71566176
60Distal lower limb amyotrophy (HP:0008944)2.65645826
61Hyperkalemia (HP:0002153)2.64026605
62Generalized muscle weakness (HP:0003324)2.63174948
63Nonprogressive disorder (HP:0003680)2.59951514
64Slender build (HP:0001533)2.59670728
65Hypothermia (HP:0002045)2.57288765
66Sudden death (HP:0001699)2.55279103
67Hamartoma of the eye (HP:0010568)2.53186291
68Prominent metopic ridge (HP:0005487)2.52395198
69Asymmetric septal hypertrophy (HP:0001670)2.51173231
70Hypoplastic ischia (HP:0003175)2.48027728
71Ketosis (HP:0001946)2.47132789
72Abnormality of the metopic suture (HP:0005556)2.42129193
73Distal lower limb muscle weakness (HP:0009053)2.40027017
74Amniotic constriction ring (HP:0009775)2.39125759
75Abnormality of placental membranes (HP:0011409)2.39125759
76EMG: neuropathic changes (HP:0003445)2.38606377
77Late onset (HP:0003584)2.35138033
78Hemiparesis (HP:0001269)2.34987062
79Hypomagnesemia (HP:0002917)2.33897599
80Metatarsus adductus (HP:0001840)2.32793913
81Hip contracture (HP:0003273)2.31144521
82Conjunctival hamartoma (HP:0100780)2.27016884
83Aplasia of the musculature (HP:0100854)2.25268714
84Scapular winging (HP:0003691)2.24172910
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.21551449
86Spinal rigidity (HP:0003306)2.20303289
87Syncope (HP:0001279)2.19782825
88Broad-based gait (HP:0002136)2.18611271
89Abnormality of the ischium (HP:0003174)2.16887005
90Limb-girdle muscle atrophy (HP:0003797)2.16301267
91Methylmalonic acidemia (HP:0002912)2.15859863
92Easy fatigability (HP:0003388)2.15373193
93Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.13924138
94Facial diplegia (HP:0001349)2.12250708
95Ulnar deviation of finger (HP:0009465)2.11556410
96Progressive macrocephaly (HP:0004481)2.10773298
97Paralysis (HP:0003470)2.07704387
98Atrial fibrillation (HP:0005110)2.07606844
99Ventricular tachycardia (HP:0004756)2.07582986
100Lower limb amyotrophy (HP:0007210)2.06927849
101Delayed gross motor development (HP:0002194)2.06197273
102Neoplasm of the adrenal gland (HP:0100631)2.04798889
103Ventricular arrhythmia (HP:0004308)2.04598657
104Respiratory insufficiency due to muscle weakness (HP:0002747)2.04063340
105Increased circulating renin level (HP:0000848)2.03472009
106EEG with generalized epileptiform discharges (HP:0011198)2.01852080
107Epileptiform EEG discharges (HP:0011182)1.98813152
108Dilated cardiomyopathy (HP:0001644)1.98729444
109Palpitations (HP:0001962)1.98260609
110Hypsarrhythmia (HP:0002521)1.96141226
111* Shoulder girdle muscle weakness (HP:0003547)1.95711830
112Pheochromocytoma (HP:0002666)1.95024503
113Left ventricular hypertrophy (HP:0001712)1.93836408
114* Abnormality of the musculature of the pelvis (HP:0001469)1.91861255
115* Abnormality of the hip-girdle musculature (HP:0001445)1.91861255
116Enlarged penis (HP:0000040)1.90556668
117* Muscular dystrophy (HP:0003560)1.90442961
118Abnormality of vitamin B metabolism (HP:0004340)1.90086202
119Neoplasm of the adrenal cortex (HP:0100641)1.89839344
120* Pelvic girdle muscle weakness (HP:0003749)1.87730840
121Tongue fasciculations (HP:0001308)1.85379517
122Primary atrial arrhythmia (HP:0001692)1.84604346
123Gaze-evoked nystagmus (HP:0000640)1.84441549
124Heart block (HP:0012722)1.83195436
125Waddling gait (HP:0002515)1.81969432
126Hepatic necrosis (HP:0002605)1.80924700
127Ventricular fibrillation (HP:0001663)1.80829352
128Akinesia (HP:0002304)1.80758210
129Long clavicles (HP:0000890)1.79804063
130Medial flaring of the eyebrow (HP:0010747)1.79729652
131Hyperventilation (HP:0002883)1.77014559
132* Abnormality of the shoulder girdle musculature (HP:0001435)1.75865426
133Progressive muscle weakness (HP:0003323)1.75233261
134Double outlet right ventricle (HP:0001719)1.74315159
135Congenital malformation of the right heart (HP:0011723)1.74315159
136Supraventricular tachycardia (HP:0004755)1.71923533
137Acute necrotizing encephalopathy (HP:0006965)1.71561329
138Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.71349826
139Febrile seizures (HP:0002373)1.71083298
140Tarsal synostosis (HP:0008368)1.70628783
141Agitation (HP:0000713)1.70105269
142Muscle fibrillation (HP:0010546)1.68430331
143Neuroendocrine neoplasm (HP:0100634)1.67716950
144Breech presentation (HP:0001623)1.66391693
145Polydipsia (HP:0001959)1.65701062
146Abnormal drinking behavior (HP:0030082)1.65701062
147Lipoatrophy (HP:0100578)1.64686383
148Abnormality of magnesium homeostasis (HP:0004921)1.64528221
149Generalized tonic-clonic seizures (HP:0002069)1.64370884
150Supraventricular arrhythmia (HP:0005115)1.63851998
151* Limb-girdle muscle weakness (HP:0003325)1.62792839
152Downturned corners of mouth (HP:0002714)1.62250313
153Renal cortical cysts (HP:0000803)1.61603319
154Achilles tendon contracture (HP:0001771)1.59530886
155Limited hip movement (HP:0008800)1.58719181
156Synostosis involving bones of the lower limbs (HP:0009138)1.57114069
157Synostosis involving bones of the feet (HP:0009140)1.57114069
158Muscular hypotonia of the trunk (HP:0008936)1.57109379
159Trismus (HP:0000211)1.56832760
160Short palpebral fissure (HP:0012745)1.54519807
161Adducted thumb (HP:0001181)1.54030327
162Bell-shaped thorax (HP:0001591)1.53867008
163Webbed neck (HP:0000465)1.53069437
164* Proximal amyotrophy (HP:0007126)1.50131452
165Congenital hip dislocation (HP:0001374)1.45756129
166Thin ribs (HP:0000883)1.44115880

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.86834954
2FRK6.08598848
3TTN5.85613388
4PHKG25.14026934
5PHKG15.14026934
6PIK3CG4.11099645
7NEK13.91032015
8MUSK3.80495534
9NME13.80176326
10FGFR22.69795203
11TRIM282.45803270
12MAP2K32.33904024
13PDK42.23655014
14PDK32.23655014
15MOS2.04357490
16TRIB31.98604801
17MAP3K71.89933667
18PINK11.87227442
19STK38L1.75227169
20MAPK121.65629496
21MAP2K41.64742790
22PDK21.51496362
23MAP4K21.48977518
24DMPK1.46941161
25WNK31.45972135
26PAK31.33985704
27PIK3CA1.32556153
28ACVR1B1.29935569
29STK391.25347127
30NTRK31.20760075
31FGFR31.18337055
32OXSR11.07490909
33BMPR1B1.06869583
34MAP2K71.06020485
35ADRBK21.04160158
36MAP2K61.02839917
37MKNK21.00304242
38NLK0.99939614
39PLK20.98176770
40SGK20.93539099
41CSNK1G10.91005284
42ERBB30.89932664
43GRK10.89915938
44BCKDK0.83886073
45EIF2AK30.83295902
46PRKCE0.81360988
47CSNK1G20.77095069
48NUAK10.73842704
49PRKAA10.72604592
50MST40.70094195
51PLK30.68969112
52PRKAA20.67924920
53MAP2K10.66713114
54AKT20.65990606
55PRKCG0.65230938
56STK160.62717864
57SGK4940.62617956
58SGK2230.62617956
59TAOK20.62304923
60CAMK2G0.62114315
61CSNK1G30.60887276
62MAP3K30.58891218
63EPHB10.57593125
64TRPM70.56794638
65RIPK10.56332861
66NEK90.56276039
67MAPKAPK30.54959507
68MAP3K40.51899981
69PASK0.50574852
70AKT30.49816575
71TIE10.49413575
72CAMK10.49400550
73MAP3K50.48958985
74STK30.48398293
75ILK0.47231581
76MAPK110.44924612
77CDK30.44897520
78PNCK0.42590489
79LIMK10.42485486
80UHMK10.42388344
81MAP3K100.40056445
82CAMK2B0.39197472
83ROCK10.37800920
84PRKACB0.37635329
85SGK10.36691833
86CSNK1A1L0.36446132
87CAMK40.35974139
88MAP3K110.35728122
89PRKG10.35349145
90ZAK0.35125840
91RPS6KA30.33776032
92BRSK20.33725925
93TAOK10.33593517
94MAP3K60.31747043
95STK240.31130573
96WNK40.29980337
97GRK70.29604831
98FGFR40.29348583
99ROCK20.28948942
100INSRR0.28886759
101PKN20.28606352
102CDK140.28166261
103PTK60.27508639
104RPS6KB10.27432932
105PAK60.26829725
106EPHA40.26388537
107SIK10.25997032
108MAPK70.25740027
109DYRK1B0.25561868
110CDK150.24828255
111EIF2AK20.23427109
112CSNK1A10.23364462
113FER0.22270259
114CDK180.22149108
115ICK0.22052473
116TAF10.22051535
117PDPK10.21828060
118PKN10.21377045
119PIM20.21359425
120CAMKK20.21346094
121PRKACG0.21071793
122CSNK1D0.20477258
123PRKACA0.19811876
124CAMK2A0.19514862
125CDK11A0.19423060
126KSR10.19095246
127MAPK130.19050011
128PDK10.18586409
129CAMK2D0.18358498
130DDR20.17808256
131LATS20.16525719
132STK110.16453500
133MARK20.16248388
134KSR20.15940708
135LATS10.15603753
136MAPK100.15595647
137MAPK40.14515503
138MARK10.14255920
139CAMK1G0.13947086
140PTK2B0.13880067
141MTOR0.13401718
142BMX0.12841890
143FGFR10.12694820
144CDK190.10763488
145CCNB10.10284088
146MAP3K10.09350766
147SGK30.09335973
148CDK50.08451249
149EEF2K0.07954559
150TNIK0.07314899
151CASK0.06692404
152PRKD30.06327908
153DAPK20.05095205

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.99539936
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.45471959
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.95971108
4Dilated cardiomyopathy_Homo sapiens_hsa054143.80376008
5Cardiac muscle contraction_Homo sapiens_hsa042603.77706821
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.77555465
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.12274359
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54568373
9Oxytocin signaling pathway_Homo sapiens_hsa049212.44337892
10Glucagon signaling pathway_Homo sapiens_hsa049222.34081294
11Starch and sucrose metabolism_Homo sapiens_hsa005002.31249357
12Insulin signaling pathway_Homo sapiens_hsa049102.11159675
13Circadian rhythm_Homo sapiens_hsa047102.06203136
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99954916
15Protein export_Homo sapiens_hsa030601.99405105
16Regulation of autophagy_Homo sapiens_hsa041401.92882981
17Propanoate metabolism_Homo sapiens_hsa006401.86552437
18Calcium signaling pathway_Homo sapiens_hsa040201.85166417
19Parkinsons disease_Homo sapiens_hsa050121.81669735
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77784990
21Oxidative phosphorylation_Homo sapiens_hsa001901.73826099
22Alzheimers disease_Homo sapiens_hsa050101.73013796
23Carbon metabolism_Homo sapiens_hsa012001.72292898
24Vitamin B6 metabolism_Homo sapiens_hsa007501.66857505
25Insulin resistance_Homo sapiens_hsa049311.64252320
26Tight junction_Homo sapiens_hsa045301.64236205
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59848242
28AMPK signaling pathway_Homo sapiens_hsa041521.47965506
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.44287765
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42307733
31Tryptophan metabolism_Homo sapiens_hsa003801.40239525
32Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40047589
33Viral myocarditis_Homo sapiens_hsa054161.36339038
34Pyruvate metabolism_Homo sapiens_hsa006201.33914093
35Fatty acid elongation_Homo sapiens_hsa000621.27384309
36Gastric acid secretion_Homo sapiens_hsa049711.27300483
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.26783017
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24779950
39Focal adhesion_Homo sapiens_hsa045101.24700177
40GnRH signaling pathway_Homo sapiens_hsa049121.15723410
41Folate biosynthesis_Homo sapiens_hsa007901.12575655
42Galactose metabolism_Homo sapiens_hsa000521.11395952
43Renin secretion_Homo sapiens_hsa049241.08902820
44Collecting duct acid secretion_Homo sapiens_hsa049661.06953151
45Biosynthesis of amino acids_Homo sapiens_hsa012301.04420805
46Phototransduction_Homo sapiens_hsa047441.03617495
47Fructose and mannose metabolism_Homo sapiens_hsa000511.03014283
48Synaptic vesicle cycle_Homo sapiens_hsa047211.01428560
49Sulfur metabolism_Homo sapiens_hsa009200.99468879
50Peroxisome_Homo sapiens_hsa041460.98847411
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94036371
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93186007
53Huntingtons disease_Homo sapiens_hsa050160.92262081
54FoxO signaling pathway_Homo sapiens_hsa040680.89078820
55MAPK signaling pathway_Homo sapiens_hsa040100.87849934
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87394257
57Ovarian steroidogenesis_Homo sapiens_hsa049130.87187408
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85017397
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84690732
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83663709
61Insulin secretion_Homo sapiens_hsa049110.82353728
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79922273
63Nitrogen metabolism_Homo sapiens_hsa009100.79722848
64Taste transduction_Homo sapiens_hsa047420.79454563
65Fatty acid degradation_Homo sapiens_hsa000710.78201753
66Ether lipid metabolism_Homo sapiens_hsa005650.77749967
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.77571914
68beta-Alanine metabolism_Homo sapiens_hsa004100.77187250
69HIF-1 signaling pathway_Homo sapiens_hsa040660.75568280
70Circadian entrainment_Homo sapiens_hsa047130.72348039
71Arginine and proline metabolism_Homo sapiens_hsa003300.70804921
72Glutamatergic synapse_Homo sapiens_hsa047240.70471808
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70304974
74Proteoglycans in cancer_Homo sapiens_hsa052050.69339127
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69332884
76Long-term depression_Homo sapiens_hsa047300.67281656
77Long-term potentiation_Homo sapiens_hsa047200.66526996
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65665625
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65630173
80Olfactory transduction_Homo sapiens_hsa047400.65599811
81mTOR signaling pathway_Homo sapiens_hsa041500.65127459
82Linoleic acid metabolism_Homo sapiens_hsa005910.64349868
83Cholinergic synapse_Homo sapiens_hsa047250.64121999
84Oocyte meiosis_Homo sapiens_hsa041140.62387815
85GABAergic synapse_Homo sapiens_hsa047270.61841911
86Pancreatic secretion_Homo sapiens_hsa049720.61218803
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60389107
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58664101
89RNA degradation_Homo sapiens_hsa030180.58128039
90Pentose phosphate pathway_Homo sapiens_hsa000300.57785518
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57534308
92ABC transporters_Homo sapiens_hsa020100.56654788
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56092210
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56003785
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55897636
96Fatty acid metabolism_Homo sapiens_hsa012120.54991295
97Amoebiasis_Homo sapiens_hsa051460.54425295
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53869283
99Selenocompound metabolism_Homo sapiens_hsa004500.53640002
100VEGF signaling pathway_Homo sapiens_hsa043700.53080733
101Melanogenesis_Homo sapiens_hsa049160.51941187
102Mineral absorption_Homo sapiens_hsa049780.50764846
103Type II diabetes mellitus_Homo sapiens_hsa049300.47041973
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46616058
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46490310
106Salivary secretion_Homo sapiens_hsa049700.46428577
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.45597975
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45404479
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44954461
110Platelet activation_Homo sapiens_hsa046110.44016103
111Fatty acid biosynthesis_Homo sapiens_hsa000610.43966284
112Renal cell carcinoma_Homo sapiens_hsa052110.43555142
113Metabolic pathways_Homo sapiens_hsa011000.43520554
114Adherens junction_Homo sapiens_hsa045200.42371998
115ECM-receptor interaction_Homo sapiens_hsa045120.42318326
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.39273219
117Dorso-ventral axis formation_Homo sapiens_hsa043200.35275291
118Arginine biosynthesis_Homo sapiens_hsa002200.35274595
119Gap junction_Homo sapiens_hsa045400.35232974
120Dopaminergic synapse_Homo sapiens_hsa047280.35190914
121Amphetamine addiction_Homo sapiens_hsa050310.34140457
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32678433
123Glioma_Homo sapiens_hsa052140.30719093
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28988664
125Nicotine addiction_Homo sapiens_hsa050330.27195789
126cAMP signaling pathway_Homo sapiens_hsa040240.26508630
127Basal cell carcinoma_Homo sapiens_hsa052170.26236597
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26030238
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25502120
130Serotonergic synapse_Homo sapiens_hsa047260.24131099
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23043027
132Butanoate metabolism_Homo sapiens_hsa006500.21421629
133ErbB signaling pathway_Homo sapiens_hsa040120.21419424
134Wnt signaling pathway_Homo sapiens_hsa043100.20675426
135Thyroid hormone synthesis_Homo sapiens_hsa049180.19514413
136PPAR signaling pathway_Homo sapiens_hsa033200.18386889
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.18081444
138Morphine addiction_Homo sapiens_hsa050320.18066656
139Hedgehog signaling pathway_Homo sapiens_hsa043400.17105368
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15408984
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.14817808

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