ANLN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.52712751
2central nervous system myelination (GO:0022010)7.52712751
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.89715636
4protein localization to kinetochore (GO:0034501)4.84664030
5nuclear pore complex assembly (GO:0051292)4.46904875
6nuclear pore organization (GO:0006999)4.41189568
7mitotic sister chromatid segregation (GO:0000070)4.40146341
8myelin maintenance (GO:0043217)4.37734554
9sister chromatid segregation (GO:0000819)4.27910026
10regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.18057117
11DNA unwinding involved in DNA replication (GO:0006268)4.10795292
12protein localization to chromosome, centromeric region (GO:0071459)4.06297057
13mitotic chromosome condensation (GO:0007076)4.03667920
14regulation of spindle organization (GO:0090224)4.03442716
15regulation of mitotic spindle organization (GO:0060236)4.03135955
16mitotic metaphase plate congression (GO:0007080)4.00133198
17spindle assembly involved in mitosis (GO:0090307)3.99968368
18fatty acid elongation (GO:0030497)3.94266870
19establishment of integrated proviral latency (GO:0075713)3.91298462
20DNA replication-dependent nucleosome assembly (GO:0006335)3.87628722
21DNA replication-dependent nucleosome organization (GO:0034723)3.87628722
22ensheathment of neurons (GO:0007272)3.78756374
23axon ensheathment (GO:0008366)3.78756374
24DNA packaging (GO:0006323)3.74897463
25microtubule polymerization or depolymerization (GO:0031109)3.73690876
26myelination (GO:0042552)3.73330544
27establishment of mitotic spindle localization (GO:0040001)3.72173198
28positive regulation of chromosome segregation (GO:0051984)3.71127374
29telomere maintenance via semi-conservative replication (GO:0032201)3.70655936
30kinetochore organization (GO:0051383)3.69625466
31metaphase plate congression (GO:0051310)3.66237300
32attachment of spindle microtubules to kinetochore (GO:0008608)3.61465690
33positive regulation of cell cycle checkpoint (GO:1901978)3.51727641
34protein complex localization (GO:0031503)3.49345726
35mitotic sister chromatid cohesion (GO:0007064)3.43544670
36microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.42782504
37establishment of mitotic spindle orientation (GO:0000132)3.42677670
38mitotic nuclear envelope disassembly (GO:0007077)3.41279863
39pore complex assembly (GO:0046931)3.39354397
40regulation of centrosome cycle (GO:0046605)3.35242968
41DNA topological change (GO:0006265)3.34425317
42establishment of chromosome localization (GO:0051303)3.34201888
43microtubule depolymerization (GO:0007019)3.33199179
44regulation of gene silencing by RNA (GO:0060966)3.30471184
45regulation of posttranscriptional gene silencing (GO:0060147)3.30471184
46regulation of gene silencing by miRNA (GO:0060964)3.30471184
47spindle checkpoint (GO:0031577)3.29310466
48mitotic recombination (GO:0006312)3.28784673
49Golgi transport vesicle coating (GO:0048200)3.28358864
50COPI coating of Golgi vesicle (GO:0048205)3.28358864
51ribosome assembly (GO:0042255)3.27707316
52DNA replication initiation (GO:0006270)3.27057439
53ventricular cardiac muscle cell development (GO:0055015)3.26997780
54regulation of chromosome segregation (GO:0051983)3.26600058
55long-chain fatty acid biosynthetic process (GO:0042759)3.24033827
56regulation of centriole replication (GO:0046599)3.22243100
57membrane disassembly (GO:0030397)3.19877834
58nuclear envelope disassembly (GO:0051081)3.19877834
59mitotic spindle organization (GO:0007052)3.18277033
60regulation of sister chromatid cohesion (GO:0007063)3.16797951
61protein localization to chromosome (GO:0034502)3.15167179
62telomere maintenance via recombination (GO:0000722)3.14909729
63DNA duplex unwinding (GO:0032508)3.11381187
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.11268369
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11268369
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11268369
67nucleobase-containing small molecule interconversion (GO:0015949)3.10087199
68establishment of mitochondrion localization (GO:0051654)3.09542380
69* cytoskeleton-dependent cytokinesis (GO:0061640)3.09107518
70paraxial mesoderm development (GO:0048339)3.08632045
71DNA conformation change (GO:0071103)3.08426828
72response to methylmercury (GO:0051597)3.08091917
73notochord development (GO:0030903)3.07544428
74mitotic spindle checkpoint (GO:0071174)3.07161947
75centrosome duplication (GO:0051298)3.06218360
76regulation of translational fidelity (GO:0006450)3.05737839
77spindle assembly checkpoint (GO:0071173)3.04483398
78positive regulation of cytokinesis (GO:0032467)3.04457400
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04255739
80regulation of spindle checkpoint (GO:0090231)3.04038880
81DNA strand elongation involved in DNA replication (GO:0006271)3.03451874
82negative regulation of chromosome segregation (GO:0051985)3.01714604
83chromatin remodeling at centromere (GO:0031055)3.01320899
84CENP-A containing nucleosome assembly (GO:0034080)3.00131825
85negative regulation of DNA repair (GO:0045738)2.98174832
86DNA geometric change (GO:0032392)2.97961133
87DNA replication checkpoint (GO:0000076)2.97872809
88regulation of RNA export from nucleus (GO:0046831)2.96868382
89regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95205328
90spindle organization (GO:0007051)2.95194282
91mitotic spindle assembly checkpoint (GO:0007094)2.95193731
92establishment of spindle orientation (GO:0051294)2.94693738
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.93978112
94negative regulation of sister chromatid segregation (GO:0033046)2.93978112
95negative regulation of mitotic sister chromatid separation (GO:2000816)2.93978112
96negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93978112
97kinetochore assembly (GO:0051382)2.93612447
98regulation of lipoprotein metabolic process (GO:0050746)2.92637960
99protein K6-linked ubiquitination (GO:0085020)2.91435509
100regulation of centrosome duplication (GO:0010824)2.91317628
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91164183
102chromatin assembly (GO:0031497)2.90148632
103establishment of spindle localization (GO:0051293)2.89973630
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88784489
105regulation of telomere maintenance via telomerase (GO:0032210)2.88725006
106IMP metabolic process (GO:0046040)2.88081113
107mitotic cell cycle (GO:0000278)2.87221207
108* mitotic cytokinesis (GO:0000281)2.87032139
109cellular protein complex localization (GO:0034629)2.86317632
110DNA ligation (GO:0006266)2.86191639
111heterochromatin organization (GO:0070828)2.85714966
112regulation of histone H3-K9 methylation (GO:0051570)2.85491717
113establishment of viral latency (GO:0019043)2.85230073
114chromosome condensation (GO:0030261)2.84896132
115histone phosphorylation (GO:0016572)2.84163170
116DNA strand elongation (GO:0022616)2.83167581
117activation of Rac GTPase activity (GO:0032863)2.83118467
118regulation of mitotic sister chromatid separation (GO:0010965)2.82818092
119regulation of mitotic sister chromatid segregation (GO:0033047)2.82818092
120regulation of sister chromatid segregation (GO:0033045)2.82818092
121histone-serine phosphorylation (GO:0035404)2.82362260
122non-recombinational repair (GO:0000726)2.81846794
123double-strand break repair via nonhomologous end joining (GO:0006303)2.81846794
124meiotic chromosome segregation (GO:0045132)2.81777275
125cell adhesion mediated by integrin (GO:0033627)2.79530247
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.78096416
127nuclear envelope organization (GO:0006998)2.77606692
128chromosome segregation (GO:0007059)2.77257013
129hemidesmosome assembly (GO:0031581)2.75883011
130DNA replication-independent nucleosome assembly (GO:0006336)2.75600202
131DNA replication-independent nucleosome organization (GO:0034724)2.75600202
132astrocyte development (GO:0014002)2.74969239
133L-serine metabolic process (GO:0006563)2.74684373
134regulation of DNA endoreduplication (GO:0032875)2.74137077
135amyloid precursor protein metabolic process (GO:0042982)2.72367799
136histone exchange (GO:0043486)2.69456611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11778769
2FOXM1_23109430_ChIP-Seq_U2OS_Human7.02718690
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.30733959
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.61029501
5* AR_21909140_ChIP-Seq_LNCAP_Human3.45089939
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.00964633
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00945834
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.65271848
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.55868772
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49436270
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41891110
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.39989035
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.39989035
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.39989035
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.38063526
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.35249934
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27178435
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27056891
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.14990338
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13458892
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02212563
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01516111
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.98950953
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.95946751
25* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.82583363
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82392611
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.81712965
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75160359
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.73257021
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73245480
31ZNF263_19887448_ChIP-Seq_K562_Human1.72072724
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70414609
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62767709
34SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62079008
35* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61992671
36* XRN2_22483619_ChIP-Seq_HELA_Human1.61180297
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56856582
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56392105
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55606783
40* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54120377
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53910518
42* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51732889
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51120896
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.46143816
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44181277
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43407712
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37418418
48CLOCK_20551151_ChIP-Seq_293T_Human1.37332517
49E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.36895410
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34524616
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34304200
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.33797951
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33642799
54* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31931220
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31931220
56SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31858466
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29969590
58* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29895466
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29244342
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28010125
61* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27675267
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27320256
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.26542200
64KDM5A_27292631_Chip-Seq_BREAST_Human1.24416032
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.24020218
66ELK1_19687146_ChIP-ChIP_HELA_Human1.23972248
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23567477
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23493904
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21616039
70* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21220890
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20894155
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18759324
73TTF2_22483619_ChIP-Seq_HELA_Human1.17192142
74* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16886750
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16721118
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16187019
77NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16142159
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15493290
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15347728
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13400919
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.13279630
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12082296
83GATA1_26923725_Chip-Seq_HPCs_Mouse1.10252557
84* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09429034
85BRD4_25478319_ChIP-Seq_HGPS_Human1.08500269
86POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08492573
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.06885906
88JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06418754
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04626918
90* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04180289
91* ATF3_27146783_Chip-Seq_COLON_Human1.03803813
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03282306
93DCP1A_22483619_ChIP-Seq_HELA_Human1.02956523
94TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01979768
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.01866963
96VDR_23849224_ChIP-Seq_CD4+_Human1.00539924
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99714941
98* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99292728
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98373660
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98110510
101* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97352433
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.97237791
103* TFEB_21752829_ChIP-Seq_HELA_Human0.97163219
104POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96687269
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95723564
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95610598
107* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95061567
108WT1_19549856_ChIP-ChIP_CCG9911_Human0.94691458
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94293657
110* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94233848
111CHD1_26751641_Chip-Seq_LNCaP_Human0.93993721
112* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93933316
113* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93570353
114GABP_19822575_ChIP-Seq_HepG2_Human0.92672285
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91276267
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91119452
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91047448
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.90412371
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90325860
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89300862
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88986964
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87965028
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86892204
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.86668306
125GABP_17652178_ChIP-ChIP_JURKAT_Human0.86538159
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85718530
127NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85341367
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84087378
129RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83773012
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82296081
131PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81677711
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79773861
133RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79431884
134TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77428693
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74520520

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.76972430
2MP0002877_abnormal_melanocyte_morpholog3.45519990
3MP0010094_abnormal_chromosome_stability2.99437277
4MP0003111_abnormal_nucleus_morphology2.98608989
5MP0008057_abnormal_DNA_replication2.87137765
6MP0005623_abnormal_meninges_morphology2.82633520
7MP0004957_abnormal_blastocyst_morpholog2.79062200
8MP0000920_abnormal_myelination2.63936829
9MP0003077_abnormal_cell_cycle2.56849311
10MP0008438_abnormal_cutaneous_collagen2.32353946
11MP0008932_abnormal_embryonic_tissue2.28158268
12MP0003693_abnormal_embryo_hatching2.23634026
13MP0010678_abnormal_skin_adnexa2.16617983
14MP0005171_absent_coat_pigmentation2.08147377
15MP0009697_abnormal_copulation2.06149424
16MP0001730_embryonic_growth_arrest2.03498001
17MP0010234_abnormal_vibrissa_follicle2.02701829
18MP0010030_abnormal_orbit_morphology2.01088682
19MP0003937_abnormal_limbs/digits/tail_de2.00974021
20MP0003941_abnormal_skin_development1.95523961
21MP0010352_gastrointestinal_tract_polyps1.89739659
22MP0003123_paternal_imprinting1.88005159
23MP0005257_abnormal_intraocular_pressure1.86785120
24MP0003705_abnormal_hypodermis_morpholog1.84604759
25MP0000537_abnormal_urethra_morphology1.78969564
26MP0000383_abnormal_hair_follicle1.76013263
27MP0000350_abnormal_cell_proliferation1.74037654
28MP0002084_abnormal_developmental_patter1.67924220
29MP0000733_abnormal_muscle_development1.64785708
30MP0001293_anophthalmia1.64077797
31MP0002085_abnormal_embryonic_tissue1.59223316
32MP0004197_abnormal_fetal_growth/weight/1.54781527
33MP0008007_abnormal_cellular_replicative1.54471793
34MP0004233_abnormal_muscle_weight1.54198529
35MP0001697_abnormal_embryo_size1.53067514
36MP0005380_embryogenesis_phenotype1.48585100
37MP0001672_abnormal_embryogenesis/_devel1.48585100
38MP0009780_abnormal_chondrocyte_physiolo1.47878762
39MP0003806_abnormal_nucleotide_metabolis1.46247779
40MP0003121_genomic_imprinting1.42194048
41MP0010307_abnormal_tumor_latency1.40093930
42MP0003136_yellow_coat_color1.39769959
43MP0003718_maternal_effect1.37029790
44MP0004185_abnormal_adipocyte_glucose1.36697549
45MP0003632_abnormal_nervous_system1.36524034
46MP0001849_ear_inflammation1.33342149
47MP0002060_abnormal_skin_morphology1.28098519
48MP0003984_embryonic_growth_retardation1.27563397
49MP0001299_abnormal_eye_distance/1.25531284
50MP0002080_prenatal_lethality1.24364039
51MP0008877_abnormal_DNA_methylation1.23484045
52MP0003566_abnormal_cell_adhesion1.22929432
53MP0002088_abnormal_embryonic_growth/wei1.22267754
54MP0005023_abnormal_wound_healing1.22191580
55MP0004134_abnormal_chest_morphology1.21634945
56MP0000462_abnormal_digestive_system1.21074038
57MP0002092_abnormal_eye_morphology1.19090434
58MP0004272_abnormal_basement_membrane1.17938696
59MP0002086_abnormal_extraembryonic_tissu1.17754244
60MP0000428_abnormal_craniofacial_morphol1.16725391
61MP0004885_abnormal_endolymph1.15827970
62MP0000647_abnormal_sebaceous_gland1.15172363
63MP0000579_abnormal_nail_morphology1.14162223
64MP0008058_abnormal_DNA_repair1.12089657
65MP0003755_abnormal_palate_morphology1.11756792
66MP0005076_abnormal_cell_differentiation1.11078573
67MP0001485_abnormal_pinna_reflex1.08645991
68MP0002111_abnormal_tail_morphology1.08385760
69MP0003634_abnormal_glial_cell1.07166883
70MP0000762_abnormal_tongue_morphology1.07054018
71MP0009672_abnormal_birth_weight1.06942935
72MP0001529_abnormal_vocalization1.06455351
73MP0003567_abnormal_fetal_cardiomyocyte1.06205182
74MP0001348_abnormal_lacrimal_gland1.05089056
75MP0000432_abnormal_head_morphology1.04199214
76MP0004133_heterotaxia1.02864739
77MP0005275_abnormal_skin_tensile1.02058736
78MP0005409_darkened_coat_color1.01323568
79MP0003690_abnormal_glial_cell1.01011869
80MP0003091_abnormal_cell_migration1.00942438
81MP0003453_abnormal_keratinocyte_physiol1.00150704
82MP0001346_abnormal_lacrimal_gland1.00108430
83MP0002697_abnormal_eye_size0.99904508
84MP0003890_abnormal_embryonic-extraembry0.99367452
85MP0000467_abnormal_esophagus_morphology0.98223534
86MP0003283_abnormal_digestive_organ0.97542926
87MP0000627_abnormal_mammary_gland0.95576399
88MP0003861_abnormal_nervous_system0.94987302
89MP0009703_decreased_birth_body0.93873731
90MP0001243_abnormal_dermal_layer0.93094727
91MP0000358_abnormal_cell_content/0.92351015
92MP0009250_abnormal_appendicular_skeleto0.91561824
93MP0000747_muscle_weakness0.88639387
94MP0002234_abnormal_pharynx_morphology0.88293183
95MP0005384_cellular_phenotype0.87704451
96MP0002796_impaired_skin_barrier0.87355148
97MP0002938_white_spotting0.86831866
98MP0005410_abnormal_fertilization0.86103751
99MP0003329_amyloid_beta_deposits0.86033462
100MP0002932_abnormal_joint_morphology0.85350421
101MP0003786_premature_aging0.85084184
102MP0002114_abnormal_axial_skeleton0.84584861
103MP0002269_muscular_atrophy0.84128788
104MP0000313_abnormal_cell_death0.84095949
105MP0000534_abnormal_ureter_morphology0.83964523
106MP0005501_abnormal_skin_physiology0.83746047
107MP0005503_abnormal_tendon_morphology0.83601381
108MP0009053_abnormal_anal_canal0.83557451
109MP0003935_abnormal_craniofacial_develop0.83414693
110MP0003385_abnormal_body_wall0.83068760
111MP0000749_muscle_degeneration0.82590525
112MP0002210_abnormal_sex_determination0.81723755
113MP0006054_spinal_hemorrhage0.81683162
114MP0005621_abnormal_cell_physiology0.81557193
115MP0002233_abnormal_nose_morphology0.81099376
116MP0003115_abnormal_respiratory_system0.80975060
117MP0002653_abnormal_ependyma_morphology0.79516081
118MP0005508_abnormal_skeleton_morphology0.79103928
119MP0000003_abnormal_adipose_tissue0.78801397
120MP0001286_abnormal_eye_development0.78743421
121MP0004742_abnormal_vestibular_system0.78640688
122MP0001145_abnormal_male_reproductive0.78238504
123MP0001216_abnormal_epidermal_layer0.78009466
124MP0001929_abnormal_gametogenesis0.77415226
125MP0002925_abnormal_cardiovascular_devel0.77398594
126MP0005197_abnormal_uvea_morphology0.76747217
127MP0001915_intracranial_hemorrhage0.76555419
128MP0005408_hypopigmentation0.75768460
129MP0003315_abnormal_perineum_morphology0.72163321
130MP0001661_extended_life_span0.71987578
131MP0000427_abnormal_hair_cycle0.70374824
132MP0001340_abnormal_eyelid_morphology0.68733234
133MP0004808_abnormal_hematopoietic_stem0.68441375
134MP0002896_abnormal_bone_mineralization0.68116466
135MP0002177_abnormal_outer_ear0.65958765
136MP0000377_abnormal_hair_follicle0.65649928
137MP0003191_abnormal_cellular_cholesterol0.64486905

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.21429052
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.21429052
3Cerebral hypomyelination (HP:0006808)3.98329077
4Termporal pattern (HP:0011008)3.75014536
5Insidious onset (HP:0003587)3.75014536
6Abnormal auditory evoked potentials (HP:0006958)3.51560119
7Premature rupture of membranes (HP:0001788)3.27342659
8Abnormality of the labia minora (HP:0012880)3.13579879
9Esophageal atresia (HP:0002032)3.10186784
10Abnormality of the corticospinal tract (HP:0002492)2.90973915
11Shallow orbits (HP:0000586)2.84152360
12Absent radius (HP:0003974)2.83820164
13Peripheral hypomyelination (HP:0007182)2.81402450
14Short nail (HP:0001799)2.81158646
15Aplasia involving forearm bones (HP:0009822)2.66551008
16Absent forearm bone (HP:0003953)2.66551008
17Hyperacusis (HP:0010780)2.63865149
18Insomnia (HP:0100785)2.58631571
19Segmental peripheral demyelination/remyelination (HP:0003481)2.57489259
20Neoplasm of the oral cavity (HP:0100649)2.57098561
21Deviation of the thumb (HP:0009603)2.53549705
22Onion bulb formation (HP:0003383)2.52362401
23Neurofibrillary tangles (HP:0002185)2.51902451
24Duplicated collecting system (HP:0000081)2.50253224
25Selective tooth agenesis (HP:0001592)2.49290842
26CNS hypomyelination (HP:0003429)2.49202838
27Ankyloglossia (HP:0010296)2.47748549
28Coronal craniosynostosis (HP:0004440)2.46103762
29Proximal placement of thumb (HP:0009623)2.45520825
30Cerebral inclusion bodies (HP:0100314)2.41980669
31Cortical dysplasia (HP:0002539)2.40398027
32Abnormality of the astrocytes (HP:0100707)2.37348726
33Astrocytoma (HP:0009592)2.37348726
34Abnormality of the preputium (HP:0100587)2.36927692
35Hypoplastic pelvis (HP:0008839)2.35398590
36Morphological abnormality of the inner ear (HP:0011390)2.35212779
37Volvulus (HP:0002580)2.30751246
38Abnormality of oral frenula (HP:0000190)2.29915378
39Fused cervical vertebrae (HP:0002949)2.27124794
40Ankle contracture (HP:0006466)2.26510577
41Ependymoma (HP:0002888)2.24977733
42Increased nuchal translucency (HP:0010880)2.23824103
43Meckel diverticulum (HP:0002245)2.22083419
44Nephroblastoma (Wilms tumor) (HP:0002667)2.20386903
45Deep philtrum (HP:0002002)2.18921631
46Abnormality of the salivary glands (HP:0010286)2.16082207
47Aplasia/hypoplasia of the humerus (HP:0006507)2.15412625
48Short humerus (HP:0005792)2.15160611
49Embryonal renal neoplasm (HP:0011794)2.14280337
50Ulnar bowing (HP:0003031)2.13695739
51Entropion (HP:0000621)2.13136203
52Abnormality of the distal phalanges of the toes (HP:0010182)2.11488529
53Chromsome breakage (HP:0040012)2.11227796
54Heterotopia (HP:0002282)2.08210155
55Stenosis of the external auditory canal (HP:0000402)2.07873910
56Alacrima (HP:0000522)2.07561421
57Abnormality of the renal collecting system (HP:0004742)2.07308440
58Facial hemangioma (HP:0000329)2.06886153
59Abnormality of the umbilical cord (HP:0010881)2.06360776
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.06347526
61Abnormality of the ileum (HP:0001549)2.06289712
62Lower limb amyotrophy (HP:0007210)2.04162262
63Distal lower limb amyotrophy (HP:0008944)2.03047389
64Broad distal phalanx of finger (HP:0009836)2.02108365
65Abnormality of the carotid arteries (HP:0005344)2.00853001
66Reduced subcutaneous adipose tissue (HP:0003758)1.99675386
67Breast hypoplasia (HP:0003187)1.99322126
68Pterygium (HP:0001059)1.95523011
69Atrophic scars (HP:0001075)1.94624986
70Microglossia (HP:0000171)1.94080735
71Spinal cord lesions (HP:0100561)1.93606844
72Syringomyelia (HP:0003396)1.93606844
73Overriding aorta (HP:0002623)1.93045079
74Foot dorsiflexor weakness (HP:0009027)1.92799483
75Abnormality of the foot musculature (HP:0001436)1.91917823
76Gastrointestinal atresia (HP:0002589)1.91754120
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91415467
78Abnormality of the calcaneus (HP:0008364)1.90632381
79Absent septum pellucidum (HP:0001331)1.90502325
80Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89133167
81Prominent occiput (HP:0000269)1.87980401
82Ectopic kidney (HP:0000086)1.87774228
83Broad face (HP:0000283)1.87511205
84Achilles tendon contracture (HP:0001771)1.87312267
85Vertebral clefting (HP:0008428)1.86947662
86Abnormality of cochlea (HP:0000375)1.86806603
87Abnormality of the fetal cardiovascular system (HP:0010948)1.86376083
88Abnormal umbilical cord blood vessels (HP:0011403)1.86376083
89Single umbilical artery (HP:0001195)1.86376083
90Spinal rigidity (HP:0003306)1.86297603
91Cafe-au-lait spot (HP:0000957)1.86177985
92Abnormal lung lobation (HP:0002101)1.85711994
93Diaphragmatic weakness (HP:0009113)1.85566258
94Myelodysplasia (HP:0002863)1.84981131
95Stridor (HP:0010307)1.83139687
96Renal duplication (HP:0000075)1.83102645
97Trismus (HP:0000211)1.82904181
98Arterial tortuosity (HP:0005116)1.82226907
99Glioma (HP:0009733)1.81646488
100Elbow flexion contracture (HP:0002987)1.81489971
101Overlapping toe (HP:0001845)1.81444900
102Postnatal microcephaly (HP:0005484)1.80433862
103Buphthalmos (HP:0000557)1.79697255
104Duodenal stenosis (HP:0100867)1.79505743
105Small intestinal stenosis (HP:0012848)1.79505743
106Abnormality of the proximal phalanges of the hand (HP:0009834)1.78979189
107Short 4th metacarpal (HP:0010044)1.78747861
108Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78747861
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78350028
110Elfin facies (HP:0004428)1.77472355
111Birth length less than 3rd percentile (HP:0003561)1.77278631
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.76596947
113Osteolytic defects of the hand bones (HP:0009699)1.76596947
114Fragile skin (HP:0001030)1.76100534
115Anteriorly placed anus (HP:0001545)1.75402600
116Increased connective tissue (HP:0009025)1.75334842
117Wormian bones (HP:0002645)1.74070672
118Spinal cord compression (HP:0002176)1.72761170
119Parakeratosis (HP:0001036)1.72423136
120Protrusio acetabuli (HP:0003179)1.72009616
121Poikiloderma (HP:0001029)1.70434645
122Hypopigmentation of the fundus (HP:0007894)1.70409062
123Tracheal stenosis (HP:0002777)1.69911878
124Abnormality of chromosome stability (HP:0003220)1.69879912
125Abnormality of the duodenum (HP:0002246)1.69773014
126Abnormality of the septum pellucidum (HP:0007375)1.69393185
127Duplication of thumb phalanx (HP:0009942)1.69050394
128Urinary urgency (HP:0000012)1.68994215
129Abnormality of the distal phalanx of the thumb (HP:0009617)1.68959452
130Rhabdomyosarcoma (HP:0002859)1.68954530
131Large earlobe (HP:0009748)1.68881422
132Ureteral duplication (HP:0000073)1.67558755
133Medulloblastoma (HP:0002885)1.67252224
134Orthostatic hypotension (HP:0001278)1.66853464
135Missing ribs (HP:0000921)1.66443489
136Colon cancer (HP:0003003)1.65921031
137Microtia (HP:0008551)1.65638764
138Decreased motor nerve conduction velocity (HP:0003431)1.65621793
139Decreased lacrimation (HP:0000633)1.65556300
140Scanning speech (HP:0002168)1.64784797
141Vertebral compression fractures (HP:0002953)1.64603557
142Choanal atresia (HP:0000453)1.64125419
143Shoulder girdle muscle weakness (HP:0003547)1.63202691
144Sensory axonal neuropathy (HP:0003390)1.63035061
145Muscle fiber splitting (HP:0003555)1.62045176
146Vertebral arch anomaly (HP:0008438)1.62018886
147Rib fusion (HP:0000902)1.61791144
148Vascular tortuosity (HP:0004948)1.61399747
149Relative macrocephaly (HP:0004482)1.60685125
15011 pairs of ribs (HP:0000878)1.60435391
151Abnormality of the antihelix (HP:0009738)1.60340718
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.59250502
153Leiomyosarcoma (HP:0100243)1.59192602
154Uterine leiomyosarcoma (HP:0002891)1.59192602
155Abnormalities of placenta or umbilical cord (HP:0001194)1.57375083
156Asymmetry of the thorax (HP:0001555)1.56679002
157Natal tooth (HP:0000695)1.55271539
158Limited elbow extension (HP:0001377)1.55076330
159Distal upper limb amyotrophy (HP:0007149)1.53886387
160Upper limb amyotrophy (HP:0009129)1.53886387
161Glossoptosis (HP:0000162)1.53549962
162Abnormality of the Achilles tendon (HP:0005109)1.53291720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.81589688
2CDC73.45620930
3MST1R3.20381517
4STK393.15682826
5TESK23.10281707
6WEE12.75748900
7MAPKAPK52.67799425
8MET2.46583727
9TTK2.43788483
10PBK2.33522831
11CDK122.06734485
12PNCK2.05848826
13NEK22.05625551
14MKNK12.00528540
15EPHB11.94681841
16EPHA21.85402358
17LIMK11.79083259
18ERBB41.68696300
19PTK21.55275473
20PDGFRA1.50033462
21MAP3K81.48797107
22TTN1.45728484
23PLK31.44949947
24PLK11.44129818
25BCR1.43989481
26CCNB11.41651739
27OXSR11.41209304
28FGFR21.40331990
29ICK1.37133873
30STK101.36610634
31UHMK11.36389975
32NEK11.34577108
33AURKB1.26085257
34SMG11.24937187
35CHEK21.24361203
36WNK11.23869150
37LATS11.21740004
38PKN11.21370658
39BRSK21.20897799
40TLK11.20148731
41DDR21.19604871
42PAK21.18011917
43CHEK11.16539426
44CLK11.14883870
45MELK1.14502252
46CSNK1A1L1.12594888
47IRAK31.11614557
48TRIB31.11018665
49CDK81.08381663
50ROCK21.07747674
51STK31.06495283
52STK41.04587111
53NME21.02267615
54BRAF1.02247380
55BMX1.01542193
56PLK40.98828182
57SCYL20.97742454
58PAK10.96883668
59CSNK1G30.96492272
60RPS6KA50.96413872
61EIF2AK30.95981211
62PAK60.92835361
63BRD40.92096737
64ATR0.90986344
65SRPK10.90216019
66ALK0.89464766
67EIF2AK10.88629523
68MAP3K90.88066516
69AURKA0.86344753
70LATS20.85818433
71ATM0.85042910
72MAP3K120.84539554
73CDK70.83328704
74CDK150.82866552
75PRKD30.82041991
76CSNK1D0.81616782
77MTOR0.80344615
78CDK140.79164497
79TAF10.77271105
80EEF2K0.77175391
81CDK180.76761778
82CDK20.75774487
83EIF2AK20.74495132
84RPS6KB20.74445512
85CDK11A0.72732062
86BRSK10.72712542
87NEK90.72316635
88PASK0.72000836
89* CDK10.71657969
90TSSK60.70946110
91LRRK20.68863879
92CSNK1G10.68687504
93CSNK1E0.68513973
94DYRK20.68093567
95CAMK2B0.67106187
96NTRK10.66607001
97FGR0.66313344
98CDK40.61843631
99MOS0.60704057
100TRPM70.60468020
101VRK10.60451134
102KSR10.60321811
103TESK10.59086721
104CDK60.58941902
105KSR20.57852151
106FGFR10.56356261
107PAK40.55967723
108CSNK1G20.55272643
109DMPK0.53867411
110WNK40.53859827
111ERBB30.52967359
112MST40.52443224
113PRKD10.52181248
114STK38L0.51212842
115TYRO30.49970237
116ILK0.48897343
117SGK2230.48031992
118SGK4940.48031992
119CAMK2D0.47984290
120ARAF0.46020255
121PLK20.45553845
122* PRKDC0.44152870
123PRKCI0.42913905
124NEK60.42499152
125AKT20.42049471
126LMTK20.41899640
127MKNK20.41392977
128PAK30.41352740
129PDK20.41339797
130VRK20.40473034
131TRIM280.40423774
132RPS6KA40.40124464
133FLT30.39935680
134CDK90.36262144
135MINK10.36125084

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.16044920
2DNA replication_Homo sapiens_hsa030303.36900190
3Mismatch repair_Homo sapiens_hsa034303.24175622
4Cell cycle_Homo sapiens_hsa041102.87856361
5Steroid biosynthesis_Homo sapiens_hsa001002.85595725
6Vitamin B6 metabolism_Homo sapiens_hsa007502.76251876
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66223317
8RNA transport_Homo sapiens_hsa030132.65471477
9Spliceosome_Homo sapiens_hsa030402.26884209
10Homologous recombination_Homo sapiens_hsa034402.17418136
11Nucleotide excision repair_Homo sapiens_hsa034202.11397383
12Nitrogen metabolism_Homo sapiens_hsa009102.08821153
13Ether lipid metabolism_Homo sapiens_hsa005652.04618805
14Non-homologous end-joining_Homo sapiens_hsa034501.99006544
15Fatty acid elongation_Homo sapiens_hsa000621.91187826
16One carbon pool by folate_Homo sapiens_hsa006701.88896835
17Fanconi anemia pathway_Homo sapiens_hsa034601.86162604
18RNA polymerase_Homo sapiens_hsa030201.79237908
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77210927
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72293143
21mRNA surveillance pathway_Homo sapiens_hsa030151.71117386
22Systemic lupus erythematosus_Homo sapiens_hsa053221.70534188
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67160694
24Base excision repair_Homo sapiens_hsa034101.60260475
25Tight junction_Homo sapiens_hsa045301.56599763
26Oocyte meiosis_Homo sapiens_hsa041141.53570471
27Basal transcription factors_Homo sapiens_hsa030221.44466595
28MicroRNAs in cancer_Homo sapiens_hsa052061.43030902
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.40809999
30Hippo signaling pathway_Homo sapiens_hsa043901.36723298
31RNA degradation_Homo sapiens_hsa030181.36371530
32Viral carcinogenesis_Homo sapiens_hsa052031.34112659
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.34003797
34Renal cell carcinoma_Homo sapiens_hsa052111.33882702
35p53 signaling pathway_Homo sapiens_hsa041151.30348086
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27179632
37ECM-receptor interaction_Homo sapiens_hsa045121.20909650
38Alcoholism_Homo sapiens_hsa050341.16277264
39Pentose phosphate pathway_Homo sapiens_hsa000301.15288388
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13644035
41N-Glycan biosynthesis_Homo sapiens_hsa005101.11796501
42Small cell lung cancer_Homo sapiens_hsa052221.08397616
43Hedgehog signaling pathway_Homo sapiens_hsa043401.06339102
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03214084
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02830951
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97129241
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97049990
48Linoleic acid metabolism_Homo sapiens_hsa005910.96407200
49Carbon metabolism_Homo sapiens_hsa012000.93090851
50TGF-beta signaling pathway_Homo sapiens_hsa043500.92880207
51Adherens junction_Homo sapiens_hsa045200.92635093
52Pyruvate metabolism_Homo sapiens_hsa006200.92131546
53Basal cell carcinoma_Homo sapiens_hsa052170.92120501
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88872965
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86808053
56Lysine degradation_Homo sapiens_hsa003100.86319711
57Focal adhesion_Homo sapiens_hsa045100.81627797
58Proteoglycans in cancer_Homo sapiens_hsa052050.79103958
59Axon guidance_Homo sapiens_hsa043600.78934247
60Pyrimidine metabolism_Homo sapiens_hsa002400.77477885
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76253797
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75684067
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74673438
64Pathways in cancer_Homo sapiens_hsa052000.74028555
65Endometrial cancer_Homo sapiens_hsa052130.71903192
66Prostate cancer_Homo sapiens_hsa052150.71689472
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69961491
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69560677
69Bladder cancer_Homo sapiens_hsa052190.68238335
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66531819
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64807584
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64766949
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.64047066
74Vibrio cholerae infection_Homo sapiens_hsa051100.63814890
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61155909
76Ribosome_Homo sapiens_hsa030100.61117432
77Dorso-ventral axis formation_Homo sapiens_hsa043200.59643590
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.59525599
79Endocytosis_Homo sapiens_hsa041440.58450027
80Wnt signaling pathway_Homo sapiens_hsa043100.57918842
81HTLV-I infection_Homo sapiens_hsa051660.56751470
82Colorectal cancer_Homo sapiens_hsa052100.56698983
83Gap junction_Homo sapiens_hsa045400.56313831
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.55219088
85Arginine and proline metabolism_Homo sapiens_hsa003300.54827319
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54521325
87Melanoma_Homo sapiens_hsa052180.54098530
88Epstein-Barr virus infection_Homo sapiens_hsa051690.53110231
89Galactose metabolism_Homo sapiens_hsa000520.53000739
90Pancreatic cancer_Homo sapiens_hsa052120.52009945
91Proteasome_Homo sapiens_hsa030500.51735397
92Selenocompound metabolism_Homo sapiens_hsa004500.51616134
93Biosynthesis of amino acids_Homo sapiens_hsa012300.51083539
94Melanogenesis_Homo sapiens_hsa049160.50940358
95Glutathione metabolism_Homo sapiens_hsa004800.49589519
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47179336
97Purine metabolism_Homo sapiens_hsa002300.46663085
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46370708
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44769749
100Ras signaling pathway_Homo sapiens_hsa040140.43424764
101Shigellosis_Homo sapiens_hsa051310.43081169
102Rap1 signaling pathway_Homo sapiens_hsa040150.42222496
103Prion diseases_Homo sapiens_hsa050200.41763454
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41498663
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41374218
106Thyroid cancer_Homo sapiens_hsa052160.40296590
107Long-term depression_Homo sapiens_hsa047300.40005911
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38410546
109Chronic myeloid leukemia_Homo sapiens_hsa052200.37553664
110Dilated cardiomyopathy_Homo sapiens_hsa054140.37216550
111Protein export_Homo sapiens_hsa030600.37143554
112Apoptosis_Homo sapiens_hsa042100.37083273
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36083198
114Estrogen signaling pathway_Homo sapiens_hsa049150.35751683
115Glioma_Homo sapiens_hsa052140.35579758
116Non-small cell lung cancer_Homo sapiens_hsa052230.35164799
117ErbB signaling pathway_Homo sapiens_hsa040120.34838807
118Sphingolipid metabolism_Homo sapiens_hsa006000.34230537
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33407609
120Amoebiasis_Homo sapiens_hsa051460.32337303
121Notch signaling pathway_Homo sapiens_hsa043300.32266401
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.32047679
123Fructose and mannose metabolism_Homo sapiens_hsa000510.31942436
124Folate biosynthesis_Homo sapiens_hsa007900.31276829
125Histidine metabolism_Homo sapiens_hsa003400.31168149
126Ovarian steroidogenesis_Homo sapiens_hsa049130.29938329
127Inositol phosphate metabolism_Homo sapiens_hsa005620.25141681
128Sulfur metabolism_Homo sapiens_hsa009200.21048346

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