ANKS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing multiple ankyrin repeats and a SAM domain. It is thought that this protein may localize to the proximal region of the primary cilium, and may play a role in renal and cardiovascular development. Mutations in this gene have been shown to cause a form of nephronophthisis (NPHP16), a chronic tubulo-interstitial nephritis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.52024354
2DNA unwinding involved in DNA replication (GO:0006268)5.30244225
3nuclear pore organization (GO:0006999)4.85494159
4synaptic vesicle maturation (GO:0016188)4.41090683
5heterochromatin organization (GO:0070828)4.39491950
6regulation of translational fidelity (GO:0006450)4.38994618
7locomotory exploration behavior (GO:0035641)4.14287600
8mitotic chromosome condensation (GO:0007076)4.12928939
9regulation of glucocorticoid secretion (GO:2000849)3.98582825
10pore complex assembly (GO:0046931)3.96738552
11protein complex localization (GO:0031503)3.92419985
12paraxial mesoderm development (GO:0048339)3.87643874
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.82666787
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.75691366
15vocalization behavior (GO:0071625)3.68775711
16pre-miRNA processing (GO:0031054)3.65432202
17DNA strand elongation involved in DNA replication (GO:0006271)3.64595067
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.59933288
19regulation of corticosteroid hormone secretion (GO:2000846)3.58130959
20cellular protein complex localization (GO:0034629)3.55979261
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.52935775
22DNA strand elongation (GO:0022616)3.52183376
23L-serine metabolic process (GO:0006563)3.48804263
24DNA replication initiation (GO:0006270)3.47952951
25mitotic sister chromatid segregation (GO:0000070)3.46875208
26protein localization to kinetochore (GO:0034501)3.44168031
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.41600641
28calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.41413549
29positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.37470001
30synaptic vesicle exocytosis (GO:0016079)3.36161936
31synapse assembly (GO:0007416)3.35690512
32ribosomal small subunit biogenesis (GO:0042274)3.33855824
33sister chromatid segregation (GO:0000819)3.31155260
34establishment of integrated proviral latency (GO:0075713)3.29769175
35mitotic sister chromatid cohesion (GO:0007064)3.29706114
36mitotic nuclear envelope disassembly (GO:0007077)3.29060714
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.28694371
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28462214
39formation of translation preinitiation complex (GO:0001731)3.27069509
40protein localization to chromosome, centromeric region (GO:0071459)3.26690019
41DNA replication checkpoint (GO:0000076)3.26236155
42regulation of mitotic spindle organization (GO:0060236)3.24868588
43convergent extension (GO:0060026)3.15557163
44regulation of synaptic vesicle exocytosis (GO:2000300)3.15403750
45DNA duplex unwinding (GO:0032508)3.14345529
46notochord development (GO:0030903)3.13129813
47proline biosynthetic process (GO:0006561)3.12495413
48neuron cell-cell adhesion (GO:0007158)3.11327842
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09720401
50nuclear envelope disassembly (GO:0051081)3.06534963
51membrane disassembly (GO:0030397)3.06534963
52protein-DNA complex disassembly (GO:0032986)3.06098679
53nucleosome disassembly (GO:0006337)3.06098679
54establishment of apical/basal cell polarity (GO:0035089)3.05827077
55telomere maintenance via semi-conservative replication (GO:0032201)3.04921829
56maturation of SSU-rRNA (GO:0030490)3.04853501
57regulation of glutamate receptor signaling pathway (GO:1900449)3.03672476
58dendritic spine morphogenesis (GO:0060997)3.03554860
59dendrite morphogenesis (GO:0048813)3.01737867
60axonal fasciculation (GO:0007413)3.00532822
61mitotic metaphase plate congression (GO:0007080)2.99181798
62exploration behavior (GO:0035640)2.98668310
63DNA geometric change (GO:0032392)2.97936668
64DNA topological change (GO:0006265)2.92878185
65innervation (GO:0060384)2.90981370
66regulation of synaptic vesicle transport (GO:1902803)2.86800554
67regulation of RNA export from nucleus (GO:0046831)2.86215249
68ribosomal large subunit biogenesis (GO:0042273)2.85327569
69long-term synaptic potentiation (GO:0060291)2.85041772
70negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.84721374
71peptidyl-arginine omega-N-methylation (GO:0035247)2.83967740
72IMP biosynthetic process (GO:0006188)2.82778670
73long term synaptic depression (GO:0060292)2.81898145
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.79959219
75neuron recognition (GO:0008038)2.78972517
76histone arginine methylation (GO:0034969)2.78502612
77cerebellar Purkinje cell layer development (GO:0021680)2.78321731
78chromosome condensation (GO:0030261)2.77937006
79folic acid-containing compound biosynthetic process (GO:0009396)2.77726156
80synaptic transmission, glutamatergic (GO:0035249)2.76456731
81regulation of posttranscriptional gene silencing (GO:0060147)2.75785764
82regulation of gene silencing by miRNA (GO:0060964)2.75785764
83regulation of gene silencing by RNA (GO:0060966)2.75785764
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75606327
85insulin secretion (GO:0030073)2.75032838
86glutamate secretion (GO:0014047)2.71228855
87DNA conformation change (GO:0071103)2.70752527
88regulation of spindle organization (GO:0090224)2.70313538
89viral transcription (GO:0019083)2.69478587
90ribosomal small subunit assembly (GO:0000028)2.68969288
91synapse organization (GO:0050808)2.68918562
92regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67768168
93protein export from nucleus (GO:0006611)2.67601217
94cell communication by electrical coupling (GO:0010644)2.65984270
95ribonucleoprotein complex biogenesis (GO:0022613)2.65770152
96layer formation in cerebral cortex (GO:0021819)2.65614692
97synaptic vesicle endocytosis (GO:0048488)2.65390494
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64476751
99IMP metabolic process (GO:0046040)2.64434508
100regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63868777
101neurotransmitter secretion (GO:0007269)2.63712487
102chromatin assembly (GO:0031497)2.62927939
103translational termination (GO:0006415)2.62860127
104regulation of nucleobase-containing compound transport (GO:0032239)2.61903390
105activation of protein kinase A activity (GO:0034199)2.60533282
106cytoskeletal anchoring at plasma membrane (GO:0007016)2.60478546
107detection of calcium ion (GO:0005513)2.60275722
108protein localization to synapse (GO:0035418)2.59777162
109regulation of neuronal synaptic plasticity (GO:0048168)2.58734075
110nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.58273716
111membrane depolarization during action potential (GO:0086010)2.57151985
112postsynaptic membrane organization (GO:0001941)2.56448243
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.56351899
114Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.55194204
115positive regulation of chromosome segregation (GO:0051984)2.53775711
116glutamate receptor signaling pathway (GO:0007215)2.53470895
117chemosensory behavior (GO:0007635)2.52853901
118negative regulation of mRNA metabolic process (GO:1903312)2.52384006
119mitotic recombination (GO:0006312)2.52081389
120telomere maintenance via recombination (GO:0000722)2.51917384
121regulation of mammary gland epithelial cell proliferation (GO:0033599)2.51902155
122cellular potassium ion homeostasis (GO:0030007)2.51125125
123negative regulation of mRNA processing (GO:0050686)2.50846850
124negative regulation of RNA splicing (GO:0033119)2.49841198
125negative regulation of histone methylation (GO:0031061)2.49647377
126cell communication involved in cardiac conduction (GO:0086065)2.49400245
127long-term memory (GO:0007616)2.49280425
128single strand break repair (GO:0000012)2.49047318
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.48349307
130nuclear envelope organization (GO:0006998)2.47894838
131regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47751200
132negative regulation of chromosome segregation (GO:0051985)2.46560743
133nucleobase biosynthetic process (GO:0046112)2.46539119
134neuron-neuron synaptic transmission (GO:0007270)2.46196630
135neuromuscular process controlling balance (GO:0050885)2.45751699
136protein retention in ER lumen (GO:0006621)2.45529323
137neurotransmitter-gated ion channel clustering (GO:0072578)2.45517955
138peptidyl-arginine N-methylation (GO:0035246)2.44810878
139peptidyl-arginine methylation (GO:0018216)2.44810878
140spliceosomal tri-snRNP complex assembly (GO:0000244)2.44754703
141positive regulation of cell cycle checkpoint (GO:1901978)2.44708138
142adherens junction assembly (GO:0034333)2.44026073
143membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.43842277
144negative regulation of DNA repair (GO:0045738)2.43765829
145ribosome biogenesis (GO:0042254)2.42688805
146sequestering of extracellular ligand from receptor (GO:0035581)2.42620910
147regulation of chromosome segregation (GO:0051983)2.41476988
148neural tube development (GO:0021915)2.41257425
149regulation of establishment of planar polarity (GO:0090175)2.40733084
150nucleobase-containing small molecule interconversion (GO:0015949)2.40034277
151DNA synthesis involved in DNA repair (GO:0000731)2.39853527
152DNA packaging (GO:0006323)2.39713260
153homocysteine metabolic process (GO:0050667)2.39691653
154cerebellar Purkinje cell differentiation (GO:0021702)2.39424333
155auditory behavior (GO:0031223)2.39324646
156serine family amino acid biosynthetic process (GO:0009070)2.39117134
157membrane hyperpolarization (GO:0060081)2.37917565
158chromatin assembly or disassembly (GO:0006333)2.37783372
159regulation of synapse structural plasticity (GO:0051823)2.37729445
160maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.37383169
161regulation of long-term neuronal synaptic plasticity (GO:0048169)2.36376356
162metaphase plate congression (GO:0051310)2.36199268
163sodium ion export (GO:0071436)2.36165432
164cell-substrate adherens junction assembly (GO:0007045)2.35953566
165focal adhesion assembly (GO:0048041)2.35953566
166translational initiation (GO:0006413)2.35112430
167response to pheromone (GO:0019236)2.34568232
168glycine transport (GO:0015816)2.32582516
169positive regulation of vesicle fusion (GO:0031340)2.32142474
170positive regulation of membrane potential (GO:0045838)2.31424184
171regulation of ARF protein signal transduction (GO:0032012)2.31397371
172response to auditory stimulus (GO:0010996)2.30406078
173negative regulation of norepinephrine secretion (GO:0010700)2.30261538
174adenosine receptor signaling pathway (GO:0001973)2.29015732
175cell migration in hindbrain (GO:0021535)2.28014161
176regulation of vesicle fusion (GO:0031338)2.27925706
177homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.27745373
178urinary tract smooth muscle contraction (GO:0014848)2.26607879
179gamma-aminobutyric acid transport (GO:0015812)2.26213578
180neuronal ion channel clustering (GO:0045161)2.25581788
181regulation of synaptic plasticity (GO:0048167)2.25158739
182glial cell proliferation (GO:0014009)2.24866449
183positive regulation of synapse maturation (GO:0090129)2.24580626
184negative regulation of catecholamine secretion (GO:0033604)2.24184377
185neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.23478742
186regulation of neuron migration (GO:2001222)2.22987624
187central nervous system projection neuron axonogenesis (GO:0021952)2.22402203
188dendritic spine organization (GO:0097061)2.21199874
189pyrimidine dimer repair (GO:0006290)2.19522713
190axon extension (GO:0048675)2.19422993
191regulation of excitatory postsynaptic membrane potential (GO:0060079)2.19231589
192neuronal action potential propagation (GO:0019227)2.19167767
193cGMP-mediated signaling (GO:0019934)2.18907736
194regulation of steroid hormone secretion (GO:2000831)2.17773959
195regulation of NFAT protein import into nucleus (GO:0051532)2.17377470
196membrane depolarization (GO:0051899)2.17034083
197regulation of postsynaptic membrane potential (GO:0060078)2.16219986
198regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.15705076
199cardiac conduction (GO:0061337)2.14231905
200neurotransmitter transport (GO:0006836)2.13867761

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98742042
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.04464767
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.84497912
4EZH2_22144423_ChIP-Seq_EOC_Human3.69467941
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23071271
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02976846
7GBX2_23144817_ChIP-Seq_PC3_Human2.95801416
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88996215
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71171183
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65683121
11DROSHA_22980978_ChIP-Seq_HELA_Human2.61508465
12* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59315933
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49195297
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48546895
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44404642
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44404642
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41672208
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41167244
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35518239
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32357851
21AR_21909140_ChIP-Seq_LNCAP_Human2.30049270
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29205659
23* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25000749
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24323646
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.22324274
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21540702
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21447554
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18892778
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.17016209
30XRN2_22483619_ChIP-Seq_HELA_Human2.16024442
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.07378478
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.05273417
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03948848
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.99493383
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.98011088
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.97683562
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93491688
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.91722908
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90108622
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.89050253
41MYC_22102868_ChIP-Seq_BL_Human1.85152309
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85107779
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84941173
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84934716
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.83609119
46ZNF263_19887448_ChIP-Seq_K562_Human1.82780819
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82414287
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80731646
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.77898976
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74937463
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.73977794
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70371449
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65836590
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62369861
55* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.61887689
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.61749439
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61088517
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54341370
59TTF2_22483619_ChIP-Seq_HELA_Human1.52898370
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52812648
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52730047
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52730047
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52730047
64* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52582585
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50365108
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49568145
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49328932
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.48258604
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48064395
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47647223
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47565625
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44822801
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43905032
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.43063544
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42245230
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41302394
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40911285
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36764610
79BCAT_22108803_ChIP-Seq_LS180_Human1.36408381
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36270967
81DCP1A_22483619_ChIP-Seq_HELA_Human1.36133665
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35173098
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33244810
84KDM2B_26808549_Chip-Seq_K562_Human1.33161914
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32855586
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32553673
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.32227419
88RACK7_27058665_Chip-Seq_MCF-7_Human1.32188972
89AHR_22903824_ChIP-Seq_MCF-7_Human1.31912413
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31675877
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31634474
92SMAD4_21799915_ChIP-Seq_A2780_Human1.31443428
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31428965
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30998115
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.30427339
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30402508
97* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30329778
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28776171
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26170490
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.25967278
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25840072
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.25757866
103ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25423945
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.24622001
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.24534391
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24439380
107CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24189464
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22311087
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22079522
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21827844
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.21505312
112TP53_18474530_ChIP-ChIP_U2OS_Human1.21078445
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.20992596
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20623248
115ETS1_20019798_ChIP-Seq_JURKAT_Human1.19413501
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18670321
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.17683925
118LXR_22292898_ChIP-Seq_THP-1_Human1.17492958
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17081211
120CLOCK_20551151_ChIP-Seq_293T_Human1.16817886
121AR_19668381_ChIP-Seq_PC3_Human1.16433524
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.15904134
123TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15751310
124RING1B_27294783_Chip-Seq_NPCs_Mouse1.15684974
125* NCOR1_26117541_ChIP-Seq_K562_Human1.15239477
126OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14931221
127P300_19829295_ChIP-Seq_ESCs_Human1.14701193
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14449518
129ISL1_27105846_Chip-Seq_CPCs_Mouse1.14377190
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.13007260
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12893607
132EP300_21415370_ChIP-Seq_HL-1_Mouse1.12534931
133KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12101207
134GABP_19822575_ChIP-Seq_HepG2_Human1.11815451
135CHD1_26751641_Chip-Seq_LNCaP_Human1.11307379
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.10406865
137CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10393586
138AR_25329375_ChIP-Seq_VCAP_Human1.10252598
139KDM5A_27292631_Chip-Seq_BREAST_Human1.10077663
140YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09878451
141BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08631555
142OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08393990
143STAT3_23295773_ChIP-Seq_U87_Human1.08104989
144ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07160088
145ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06805189
146TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06544397
147AR_21572438_ChIP-Seq_LNCaP_Human1.05818564
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05743891
149ATF3_27146783_Chip-Seq_COLON_Human1.05536196
150CBX2_27304074_Chip-Seq_ESCs_Mouse1.05040251
151TP53_16413492_ChIP-PET_HCT116_Human1.04176567
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02268858
153NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01224143
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01127015
155SMAD3_21741376_ChIP-Seq_ESCs_Human1.01119278
156* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00924443
157SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00824859
158SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99959361
159UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99791820
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99593341
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.99516050
162SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99304923
163IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97783669
164SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97681713
165VDR_21846776_ChIP-Seq_THP-1_Human0.96457388
166ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96255704
167ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96072597
168TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95577274
169SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95388810
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95324284
171NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95200579
172HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94696490
173SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94462256
174TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93729723
175TET1_21490601_ChIP-Seq_MESCs_Mouse0.93338791
176ESR1_21235772_ChIP-Seq_MCF-7_Human0.92858039
177AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92758576
178SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92537408
179CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92075502
180* TCF4_23295773_ChIP-Seq_U87_Human0.92054475
181NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91746904
182PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91691461
183SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91508375
184ZNF274_21170338_ChIP-Seq_K562_Hela0.91467765
185OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90601088
186YY1_21170310_ChIP-Seq_MESCs_Mouse0.90411231
187LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90272190
188ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90229892
189RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90221944
190RUNX2_22187159_ChIP-Seq_PCA_Human0.89560576
191* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87980152
192STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87763160
193* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86451077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.41846455
2MP0004957_abnormal_blastocyst_morpholog3.06321739
3MP0003111_abnormal_nucleus_morphology2.99343588
4MP0010030_abnormal_orbit_morphology2.98251100
5MP0002736_abnormal_nociception_after2.91719786
6MP0003693_abnormal_embryo_hatching2.83116072
7MP0003635_abnormal_synaptic_transmissio2.76963079
8MP0009780_abnormal_chondrocyte_physiolo2.61487037
9MP0004270_analgesia2.60497910
10MP0001968_abnormal_touch/_nociception2.58948020
11MP0010094_abnormal_chromosome_stability2.56988246
12MP0008932_abnormal_embryonic_tissue2.40923710
13MP0003283_abnormal_digestive_organ2.34707321
14MP0005645_abnormal_hypothalamus_physiol2.29268215
15MP0000537_abnormal_urethra_morphology2.25875440
16MP0004858_abnormal_nervous_system2.23741906
17MP0003077_abnormal_cell_cycle2.21379571
18MP0002909_abnormal_adrenal_gland2.17653515
19MP0002734_abnormal_mechanical_nocicepti2.17127469
20MP0003941_abnormal_skin_development2.17115041
21MP0001730_embryonic_growth_arrest2.12978109
22MP0004043_abnormal_pH_regulation2.05721760
23MP0009672_abnormal_birth_weight2.03842985
24MP0002063_abnormal_learning/memory/cond2.00573813
25MP0008057_abnormal_DNA_replication1.97163290
26MP0009745_abnormal_behavioral_response1.95518326
27MP0002064_seizures1.94480930
28MP0003890_abnormal_embryonic-extraembry1.93651442
29MP0003787_abnormal_imprinting1.92774927
30MP0004185_abnormal_adipocyte_glucose1.88874381
31MP0000569_abnormal_digit_pigmentation1.87748733
32MP0005076_abnormal_cell_differentiation1.85673903
33MP0010352_gastrointestinal_tract_polyps1.85459096
34MP0002735_abnormal_chemical_nociception1.82390519
35MP0003880_abnormal_central_pattern1.79932904
36MP0000350_abnormal_cell_proliferation1.78939264
37MP0009384_cardiac_valve_regurgitation1.78142683
38MP0002572_abnormal_emotion/affect_behav1.77765794
39MP0003183_abnormal_peptide_metabolism1.77057944
40MP0001984_abnormal_olfaction1.76611502
41MP0000778_abnormal_nervous_system1.75837306
42MP0003937_abnormal_limbs/digits/tail_de1.75580282
43MP0002084_abnormal_developmental_patter1.75330135
44MP0005380_embryogenesis_phenotype1.74361426
45MP0001672_abnormal_embryogenesis/_devel1.74361426
46MP0000013_abnormal_adipose_tissue1.74354275
47MP0002085_abnormal_embryonic_tissue1.73016787
48MP0002733_abnormal_thermal_nociception1.72930969
49MP0002249_abnormal_larynx_morphology1.72627418
50MP0002638_abnormal_pupillary_reflex1.72152494
51MP0001299_abnormal_eye_distance/1.70128705
52MP0009379_abnormal_foot_pigmentation1.69079995
53MP0008058_abnormal_DNA_repair1.66707995
54MP0002697_abnormal_eye_size1.65880342
55MP0004885_abnormal_endolymph1.65578562
56MP0000566_synostosis1.61891806
57MP0002184_abnormal_innervation1.61286341
58MP0009046_muscle_twitch1.60764393
59MP0001502_abnormal_circadian_rhythm1.59266915
60MP0001486_abnormal_startle_reflex1.58696316
61MP0000428_abnormal_craniofacial_morphol1.56735358
62MP0002272_abnormal_nervous_system1.56279461
63MP0003984_embryonic_growth_retardation1.56035423
64MP0008569_lethality_at_weaning1.55697974
65MP0003942_abnormal_urinary_system1.53072229
66MP0001697_abnormal_embryo_size1.52135581
67MP0003122_maternal_imprinting1.51579225
68MP0002080_prenatal_lethality1.48508943
69MP0002088_abnormal_embryonic_growth/wei1.47947083
70MP0001970_abnormal_pain_threshold1.44851161
71MP0001293_anophthalmia1.44120630
72MP0002138_abnormal_hepatobiliary_system1.43422844
73MP0002877_abnormal_melanocyte_morpholog1.43091794
74MP0003045_fibrosis1.42402887
75MP0008007_abnormal_cellular_replicative1.41761374
76MP0002067_abnormal_sensory_capabilities1.38977036
77MP0003566_abnormal_cell_adhesion1.38673699
78MP0003385_abnormal_body_wall1.38317775
79MP0001348_abnormal_lacrimal_gland1.36559343
80MP0000762_abnormal_tongue_morphology1.33585165
81MP0000003_abnormal_adipose_tissue1.33067263
82MP0002557_abnormal_social/conspecific_i1.30818453
83MP0002896_abnormal_bone_mineralization1.29822262
84MP0002928_abnormal_bile_duct1.28758868
85MP0003119_abnormal_digestive_system1.28387018
86MP0005423_abnormal_somatic_nervous1.28276665
87MP0000955_abnormal_spinal_cord1.28194946
88MP0003172_abnormal_lysosome_physiology1.28031957
89MP0010386_abnormal_urinary_bladder1.27389263
90MP0002086_abnormal_extraembryonic_tissu1.26573298
91MP0004811_abnormal_neuron_physiology1.26418751
92MP0003123_paternal_imprinting1.22554181
93MP0003879_abnormal_hair_cell1.20610541
94MP0001944_abnormal_pancreas_morphology1.20544622
95MP0002111_abnormal_tail_morphology1.19847723
96MP0009703_decreased_birth_body1.18256410
97MP0006292_abnormal_olfactory_placode1.17943585
98MP0005623_abnormal_meninges_morphology1.16988070
99MP0002090_abnormal_vision1.15968608
100MP0004197_abnormal_fetal_growth/weight/1.15637663
101MP0001849_ear_inflammation1.15459075
102MP0002234_abnormal_pharynx_morphology1.14948174
103MP0001440_abnormal_grooming_behavior1.14946171
104MP0009053_abnormal_anal_canal1.14902620
105MP0003115_abnormal_respiratory_system1.13454784
106MP0003861_abnormal_nervous_system1.12768436
107MP0008961_abnormal_basal_metabolism1.12741616
108MP0002092_abnormal_eye_morphology1.12597558
109MP0003633_abnormal_nervous_system1.12352821
110MP0001485_abnormal_pinna_reflex1.11779242
111MP0001286_abnormal_eye_development1.10400034
112MP0002882_abnormal_neuron_morphology1.10386718
113MP0000579_abnormal_nail_morphology1.10112650
114MP0004145_abnormal_muscle_electrophysio1.09562015
115MP0000432_abnormal_head_morphology1.08745746
116MP0010307_abnormal_tumor_latency1.08350932
117MP0001346_abnormal_lacrimal_gland1.07920443
118MP0000631_abnormal_neuroendocrine_gland1.07792582
119MP0003935_abnormal_craniofacial_develop1.07753141
120MP0003136_yellow_coat_color1.07745749
121MP0002693_abnormal_pancreas_physiology1.06986022
122MP0002233_abnormal_nose_morphology1.05054901
123MP0008438_abnormal_cutaneous_collagen1.04598473
124MP0009697_abnormal_copulation1.04542443
125MP0001501_abnormal_sleep_pattern1.03155427
126MP0004924_abnormal_behavior1.01965705
127MP0005386_behavior/neurological_phenoty1.01965705
128MP0005501_abnormal_skin_physiology1.00538526
129MP0000678_abnormal_parathyroid_gland1.00026410
130MP0002396_abnormal_hematopoietic_system0.98487993
131MP0001661_extended_life_span0.98036886
132MP0005409_darkened_coat_color0.97816870
133MP0002066_abnormal_motor_capabilities/c0.97346829
134MP0002089_abnormal_postnatal_growth/wei0.97268921
135MP0005257_abnormal_intraocular_pressure0.97093903
136MP0003252_abnormal_bile_duct0.96870186
137MP0010234_abnormal_vibrissa_follicle0.95847011
138MP0003634_abnormal_glial_cell0.95133970
139MP0000751_myopathy0.94701941
140MP0003718_maternal_effect0.94612994
141MP0003705_abnormal_hypodermis_morpholog0.94450152
142MP0001188_hyperpigmentation0.94411982
143MP0000313_abnormal_cell_death0.94397721
144MP0004742_abnormal_vestibular_system0.93768238
145MP0003755_abnormal_palate_morphology0.93283683
146MP0002796_impaired_skin_barrier0.92438229
147MP0004808_abnormal_hematopoietic_stem0.91770255
148MP0002152_abnormal_brain_morphology0.91228632
149MP0005646_abnormal_pituitary_gland0.88039165
150MP0004264_abnormal_extraembryonic_tissu0.87869627
151MP0000462_abnormal_digestive_system0.87601095
152MP0009278_abnormal_bone_marrow0.87293131
153MP0001270_distended_abdomen0.86707446
154MP0002114_abnormal_axial_skeleton0.84652464
155MP0002069_abnormal_eating/drinking_beha0.84138047
156MP0003690_abnormal_glial_cell0.83932537
157MP0004233_abnormal_muscle_weight0.83768516
158MP0003567_abnormal_fetal_cardiomyocyte0.83229050
159MP0004085_abnormal_heartbeat0.83051327
160MP0002837_dystrophic_cardiac_calcinosis0.81621347
161MP0004272_abnormal_basement_membrane0.81604032
162MP0002108_abnormal_muscle_morphology0.80659774
163MP0002060_abnormal_skin_morphology0.80330933
164MP0005503_abnormal_tendon_morphology0.79923148
165MP0009250_abnormal_appendicular_skeleto0.79675863
166MP0005666_abnormal_adipose_tissue0.79462374
167MP0003631_nervous_system_phenotype0.79226533
168MP0000534_abnormal_ureter_morphology0.78189652
169MP0003786_premature_aging0.78110036
170MP0002938_white_spotting0.77578122
171MP0002254_reproductive_system_inflammat0.77524355
172MP0005499_abnormal_olfactory_system0.77206899
173MP0005394_taste/olfaction_phenotype0.77206899
174MP0001177_atelectasis0.77093507
175MP0003315_abnormal_perineum_morphology0.76839385
176MP0004133_heterotaxia0.75771281
177MP0000733_abnormal_muscle_development0.75740847
178MP0010630_abnormal_cardiac_muscle0.75580231
179MP0001765_abnormal_ion_homeostasis0.74843159
180MP0000467_abnormal_esophagus_morphology0.74740126
181MP0002925_abnormal_cardiovascular_devel0.73411411
182MP0000049_abnormal_middle_ear0.72241218
183MP0005375_adipose_tissue_phenotype0.71758000
184MP0005535_abnormal_body_temperature0.71674999
185MP0002116_abnormal_craniofacial_bone0.70450919
186MP0001958_emphysema0.70433848

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.18913316
2Focal seizures (HP:0007359)3.43087197
3Visual hallucinations (HP:0002367)3.40574199
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.22258438
5Myokymia (HP:0002411)3.18265659
6Hyperacusis (HP:0010780)3.03641382
7Atonic seizures (HP:0010819)2.89945902
8Increased nuchal translucency (HP:0010880)2.89400504
9Large for gestational age (HP:0001520)2.87711195
10Ankle clonus (HP:0011448)2.78184875
11Epileptic encephalopathy (HP:0200134)2.73553599
12Chromosomal breakage induced by crosslinking agents (HP:0003221)2.72120711
13Selective tooth agenesis (HP:0001592)2.71245179
14Chromsome breakage (HP:0040012)2.71111974
15Shallow orbits (HP:0000586)2.66999652
16Blue irides (HP:0000635)2.66449892
17Broad distal phalanx of finger (HP:0009836)2.63484981
18Bundle branch block (HP:0011710)2.61654533
19Action tremor (HP:0002345)2.57649469
20Ulnar bowing (HP:0003031)2.56141711
21Overriding aorta (HP:0002623)2.55018573
22Supranuclear gaze palsy (HP:0000605)2.49596012
23Reticulocytopenia (HP:0001896)2.49324804
24Birth length less than 3rd percentile (HP:0003561)2.42090718
25Truncus arteriosus (HP:0001660)2.40815599
26Increased circulating renin level (HP:0000848)2.38162253
27Progressive cerebellar ataxia (HP:0002073)2.35629754
28Disproportionate tall stature (HP:0001519)2.32513400
29Absence seizures (HP:0002121)2.32365209
30Anxiety (HP:0000739)2.31650054
31Ankyloglossia (HP:0010296)2.28829828
32Progressive muscle weakness (HP:0003323)2.28213929
33Duplication of thumb phalanx (HP:0009942)2.27243316
34Congenital glaucoma (HP:0001087)2.22402996
35High anterior hairline (HP:0009890)2.19712422
36Febrile seizures (HP:0002373)2.19166933
37Hypoventilation (HP:0002791)2.18397563
38Ketoacidosis (HP:0001993)2.18121138
39Hand muscle atrophy (HP:0009130)2.17787868
40Impaired smooth pursuit (HP:0007772)2.17260769
41Metabolic alkalosis (HP:0200114)2.15013275
42Truncal ataxia (HP:0002078)2.14594902
43Cerebral aneurysm (HP:0004944)2.13084741
44Abnormality of calcium-phosphate metabolism (HP:0100530)2.11505818
45Arnold-Chiari malformation (HP:0002308)2.11246706
46Hyperactive renin-angiotensin system (HP:0000841)2.10456932
47Missing ribs (HP:0000921)2.10058306
48Hemiplegia (HP:0002301)2.08937036
49Distal upper limb amyotrophy (HP:0007149)2.08132980
50Upper limb amyotrophy (HP:0009129)2.08132980
51Hypercortisolism (HP:0001578)2.07713086
52Drooling (HP:0002307)2.07349692
53Excessive salivation (HP:0003781)2.07349692
54Agitation (HP:0000713)2.06667269
55Decreased circulating renin level (HP:0003351)2.06198117
56Dialeptic seizures (HP:0011146)2.05230904
57Narrow nasal bridge (HP:0000446)2.04858073
58Neoplasm of the heart (HP:0100544)2.04480311
59EEG with generalized epileptiform discharges (HP:0011198)2.04184394
60Broad metatarsal (HP:0001783)2.03282433
61Generalized tonic-clonic seizures (HP:0002069)2.03188392
62Facial cleft (HP:0002006)2.02675191
63Abnormal number of incisors (HP:0011064)2.02581794
64Epileptiform EEG discharges (HP:0011182)2.02544706
65Partial duplication of thumb phalanx (HP:0009944)2.02523448
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02140832
67Macroorchidism (HP:0000053)2.01827334
68Turricephaly (HP:0000262)2.01661292
69Insomnia (HP:0100785)2.00570017
70Renal duplication (HP:0000075)2.00347475
71Buphthalmos (HP:0000557)1.99537984
72Bradycardia (HP:0001662)1.98299634
73Abnormality of renin-angiotensin system (HP:0000847)1.97703860
74Premature rupture of membranes (HP:0001788)1.97202567
75Premature skin wrinkling (HP:0100678)1.96712470
76Mutism (HP:0002300)1.96523097
77Depression (HP:0000716)1.96470352
78Dysmetria (HP:0001310)1.95877788
79Hypsarrhythmia (HP:0002521)1.95822468
80Patellar dislocation (HP:0002999)1.94813117
81Dysmetric saccades (HP:0000641)1.93807705
82Hyperinsulinemic hypoglycemia (HP:0000825)1.93163126
83Gastrointestinal atresia (HP:0002589)1.92531020
84Bowel incontinence (HP:0002607)1.91668245
85Ventricular fibrillation (HP:0001663)1.91452383
86Hypokalemia (HP:0002900)1.89682670
87Hypokalemic alkalosis (HP:0001949)1.89547598
88Choanal stenosis (HP:0000452)1.89219664
89Abnormality of cochlea (HP:0000375)1.88117598
90Abnormality of the calcaneus (HP:0008364)1.87444131
91Hyperglycemia (HP:0003074)1.87230921
92Abnormality of the lower motor neuron (HP:0002366)1.87148758
93Partial duplication of the phalanx of hand (HP:0009999)1.87107073
94Broad thumb (HP:0011304)1.87047595
95Long palpebral fissure (HP:0000637)1.86700581
96Abnormality of the umbilical cord (HP:0010881)1.86640017
97Dysostosis multiplex (HP:0000943)1.86636089
98Genetic anticipation (HP:0003743)1.86070937
99Morphological abnormality of the middle ear (HP:0008609)1.85429047
100Abnormality of the distal phalanx of the thumb (HP:0009617)1.85101991
101Intestinal atresia (HP:0011100)1.84050350
102Prolonged QT interval (HP:0001657)1.83766748
103Pheochromocytoma (HP:0002666)1.82244680
104Congenital stationary night blindness (HP:0007642)1.81631199
105Coronal craniosynostosis (HP:0004440)1.81304860
106Thin ribs (HP:0000883)1.80972998
107Atresia of the external auditory canal (HP:0000413)1.80663958
108Hemiparesis (HP:0001269)1.80207709
109Trismus (HP:0000211)1.80047735
110Abnormality of oral frenula (HP:0000190)1.79433926
111Hyperventilation (HP:0002883)1.78320076
112Atrophic scars (HP:0001075)1.78220005
113Flat cornea (HP:0007720)1.78170993
114Postural instability (HP:0002172)1.77874421
115Deviation of the thumb (HP:0009603)1.77756479
116Abnormality of dentin (HP:0010299)1.77368614
117Urethral obstruction (HP:0000796)1.76413941
118Abnormal lung lobation (HP:0002101)1.76291909
119Abnormal large intestine physiology (HP:0012700)1.75867577
120Absent radius (HP:0003974)1.75370368
121Biconcave vertebral bodies (HP:0004586)1.75095344
122Progressive external ophthalmoplegia (HP:0000590)1.74980798
123Long toe (HP:0010511)1.74410895
124Spastic diplegia (HP:0001264)1.74323016
125Atelectasis (HP:0100750)1.74199444
126Shawl scrotum (HP:0000049)1.73788250
127Dysdiadochokinesis (HP:0002075)1.73737595
128Adrenal overactivity (HP:0002717)1.73689850
129Abnormal EKG (HP:0003115)1.73002533
130Hypomagnesemia (HP:0002917)1.72901877
131Cerebral inclusion bodies (HP:0100314)1.72013960
132Lower limb muscle weakness (HP:0007340)1.71993705
133Protrusio acetabuli (HP:0003179)1.71816119
134Intention tremor (HP:0002080)1.71474473
135Abnormality of the fetal cardiovascular system (HP:0010948)1.71429730
136Abnormal umbilical cord blood vessels (HP:0011403)1.71429730
137Single umbilical artery (HP:0001195)1.71429730
138Retinal atrophy (HP:0001105)1.70595560
139Proximal placement of thumb (HP:0009623)1.70359302
140Gaze-evoked nystagmus (HP:0000640)1.70150161
141Long eyelashes (HP:0000527)1.70083557
142Breech presentation (HP:0001623)1.69574751
143Exotropia (HP:0000577)1.68578515
144Mitral valve prolapse (HP:0001634)1.68381171
145Pointed chin (HP:0000307)1.68258256
146Multiple enchondromatosis (HP:0005701)1.68127915
147Arterial tortuosity (HP:0005116)1.67989930
148Decreased subcutaneous fat (HP:0001002)1.67535971
149Aplasia of the phalanges of the hand (HP:0009802)1.67522154
150Aplasia involving bones of the extremities (HP:0009825)1.67522154
151Aplasia involving bones of the upper limbs (HP:0009823)1.67522154
152Spinal rigidity (HP:0003306)1.67307109
153Bronchomalacia (HP:0002780)1.66832878
154Obstructive sleep apnea (HP:0002870)1.66734489
155Torticollis (HP:0000473)1.66712767
156Open mouth (HP:0000194)1.66270889
157Hypoglycemic seizures (HP:0002173)1.66121700
158Impaired vibration sensation in the lower limbs (HP:0002166)1.65718441
159Broad phalanges of the hand (HP:0009768)1.65644045
160Renovascular hypertension (HP:0100817)1.65306952
161Elfin facies (HP:0004428)1.65245576
162Broad finger (HP:0001500)1.65054700
163Cheekbone underdevelopment (HP:0010669)1.64305964
164Abnormal eating behavior (HP:0100738)1.63324259
165Fragile skin (HP:0001030)1.63274636
166Bladder diverticulum (HP:0000015)1.63185721
167Broad-based gait (HP:0002136)1.63158526
168Unilateral renal agenesis (HP:0000122)1.62946985
169Abnormality of the phalanges of the hallux (HP:0010057)1.62022136
170Hyperthyroidism (HP:0000836)1.61877461
171Skull defect (HP:0001362)1.61035703
172Nephroblastoma (Wilms tumor) (HP:0002667)1.60713832
173Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59794479
174Transposition of the great arteries (HP:0001669)1.59138050
175Abnormal connection of the cardiac segments (HP:0011545)1.59138050
176Abnormal ventriculo-arterial connection (HP:0011563)1.59138050
177Pseudobulbar signs (HP:0002200)1.59024954
178Bowel diverticulosis (HP:0005222)1.57950225
179Microvesicular hepatic steatosis (HP:0001414)1.56126150
180Cortical dysplasia (HP:0002539)1.56124894
181Abnormality of abdominal situs (HP:0011620)1.56015503
182Abdominal situs inversus (HP:0003363)1.56015503
183Abnormality of reticulocytes (HP:0004312)1.55846047
184Absent epiphyses (HP:0010577)1.55635281
185Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55635281
186Obsessive-compulsive behavior (HP:0000722)1.55596766
187Ectopic kidney (HP:0000086)1.54970414
188Pterygium (HP:0001059)1.54522557
189Aplasia involving forearm bones (HP:0009822)1.54092192
190Absent forearm bone (HP:0003953)1.54092192
191Embryonal renal neoplasm (HP:0011794)1.53186778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR23.83881897
2SMG13.33295081
3TTK3.21492687
4NTRK33.04574203
5TYRO33.01119767
6CDC72.95400905
7PDGFRA2.94072516
8CDK122.88651710
9MARK12.71689765
10NTRK22.70863140
11BUB12.57608764
12TRIB32.51456160
13ICK2.20142477
14MST1R2.17233580
15FGFR42.15855490
16MAPK152.08818677
17LATS11.92658350
18MINK11.90044692
19MAP3K101.84755711
20EPHA21.84478961
21INSRR1.79005102
22MET1.76296107
23PRKD31.75565297
24SRPK11.73916198
25WNK31.70358309
26TSSK61.67612866
27GRK71.63732073
28WNK41.62575353
29PBK1.62195700
30EPHA41.57036486
31PAK61.56821555
32NME21.53675972
33DDR21.51998419
34DAPK21.48706826
35CHEK21.44275248
36FGFR31.44135720
37RET1.43262840
38VRK21.37129792
39MAP3K41.37098574
40MAP3K91.36958611
41MAPK131.36722976
42BMX1.36527195
43UHMK11.32861660
44EIF2AK11.30286617
45MTOR1.26317038
46DYRK1A1.24627837
47PAK41.22477273
48DMPK1.21906082
49IRAK31.20138455
50PRKCH1.19133493
51BRSK11.15214474
52SGK4941.14601592
53SGK2231.14601592
54NEK21.14553718
55STK381.14317764
56MAP3K21.13016037
57TAF11.12353902
58CDK71.11454895
59WEE11.10455148
60ATR1.09432934
61NEK11.08543145
62MAP3K81.06933795
63CHEK11.06795544
64RPS6KB21.06260852
65CAMK1G1.05623132
66MKNK11.05163205
67SIK11.04198634
68BRAF1.01780780
69SGK21.01692486
70NTRK11.01457934
71CDK50.98982158
72PLK30.98775947
73CAMKK10.98321345
74PLK10.97114162
75CASK0.96244092
76ERBB40.95949089
77PDGFRB0.95837183
78CAMK2B0.95595454
79WNK10.95547951
80TTN0.95050753
81CDC42BPA0.94413780
82STK160.90531807
83PLK40.90193572
84KSR20.90020073
85PAK30.89698434
86SGK30.89674998
87LMTK20.89427109
88PKN20.88081854
89PTK60.87337692
90PASK0.85145297
91FGFR10.84383489
92AURKB0.84363905
93SIK20.84252796
94SCYL20.83903215
95PNCK0.81821846
96CLK10.80518479
97KSR10.78705694
98PTK20.77885836
99PHKG20.77486230
100PHKG10.77486230
101CDK40.75936375
102MARK20.75806304
103BRD40.75780800
104STK30.75640120
105CAMK2D0.75520746
106PAK20.74809598
107NME10.74307407
108MKNK20.74058566
109TAOK20.73814961
110BRSK20.73571156
111CAMK1D0.72609959
112MAP2K60.72395003
113CDK20.72001189
114OXSR10.71432168
115RIPK10.70958073
116CDK80.70957122
117GRK50.70230740
118PINK10.70158630
119CDK10.68556089
120HIPK20.67206841
121AURKA0.66523492
122EEF2K0.66357481
123EPHB20.66173161
124TNIK0.65894392
125PRPF4B0.65440998
126PDPK10.64903338
127CAMK2A0.63938795
128ATM0.63679117
129TNK20.63657285
130CAMKK20.63649398
131CAMK40.63507594
132EPHA30.63382637
133DYRK1B0.63179090
134PRKD10.62299680
135MAPKAPK50.61362188
136RAF10.59382713
137FES0.58862505
138ARAF0.58440763
139STK40.56935471
140SGK10.56074355
141MAP2K40.56009031
142PTK2B0.55800542
143CDK11A0.54231781
144PRKCG0.53927831
145PLK20.53760177
146RPS6KA20.53520763
147PDK10.53334063
148MELK0.52523896
149ILK0.51756134
150CDK150.51527684
151LRRK20.50916910
152FER0.50612756
153LATS20.50127166
154CAMK2G0.49328012
155ADRBK10.48637428
156TGFBR20.48508629
157IRAK20.48409972
158MAP2K20.47922571
159CDK180.46791747
160ALK0.46780248
161PKN10.46590010
162MAP2K70.46188450
163PRKCE0.45612091
164MAP3K10.44956397
165ROCK10.44689346
166SIK30.43671356
167CSNK1E0.43641116
168CAMK10.43597914
169PDK30.42414289
170PRKDC0.41932531
171EIF2AK20.41777077
172CDK90.39671929
173PRKCI0.38488969
174CDK60.38083132
175PAK10.37216486

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.63701313
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89585268
3Mismatch repair_Homo sapiens_hsa034302.58584102
4Insulin secretion_Homo sapiens_hsa049112.38932242
5Olfactory transduction_Homo sapiens_hsa047402.30819957
6Cell cycle_Homo sapiens_hsa041102.29672965
7Nicotine addiction_Homo sapiens_hsa050332.29657694
8Vitamin B6 metabolism_Homo sapiens_hsa007502.29513255
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.23068046
10One carbon pool by folate_Homo sapiens_hsa006702.14008164
11Synaptic vesicle cycle_Homo sapiens_hsa047212.11786862
12Ribosome_Homo sapiens_hsa030102.08130194
13RNA transport_Homo sapiens_hsa030132.07860428
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05632427
15Circadian entrainment_Homo sapiens_hsa047132.04692542
16Biosynthesis of amino acids_Homo sapiens_hsa012302.02284724
17Base excision repair_Homo sapiens_hsa034101.97450951
18Spliceosome_Homo sapiens_hsa030401.95984025
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95146049
20Amphetamine addiction_Homo sapiens_hsa050311.91651022
21Long-term potentiation_Homo sapiens_hsa047201.89816607
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89283712
23Glutamatergic synapse_Homo sapiens_hsa047241.84429104
24mRNA surveillance pathway_Homo sapiens_hsa030151.83707710
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79033001
26GABAergic synapse_Homo sapiens_hsa047271.78904511
27Thyroid cancer_Homo sapiens_hsa052161.75694103
28Morphine addiction_Homo sapiens_hsa050321.73644314
29Non-homologous end-joining_Homo sapiens_hsa034501.73200688
30Nucleotide excision repair_Homo sapiens_hsa034201.72516598
31Dopaminergic synapse_Homo sapiens_hsa047281.72188685
32Taste transduction_Homo sapiens_hsa047421.72095703
33Type II diabetes mellitus_Homo sapiens_hsa049301.70279503
34Salivary secretion_Homo sapiens_hsa049701.63876892
35Cocaine addiction_Homo sapiens_hsa050301.60835561
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.57275446
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57162863
38Gastric acid secretion_Homo sapiens_hsa049711.55819172
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54791153
40Renin secretion_Homo sapiens_hsa049241.53230901
41Adherens junction_Homo sapiens_hsa045201.51876979
42Central carbon metabolism in cancer_Homo sapiens_hsa052301.51216691
43Cholinergic synapse_Homo sapiens_hsa047251.50036657
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47065908
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45470040
46Homologous recombination_Homo sapiens_hsa034401.43362658
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.41438062
48Serotonergic synapse_Homo sapiens_hsa047261.35502873
49Basal cell carcinoma_Homo sapiens_hsa052171.35096602
50Long-term depression_Homo sapiens_hsa047301.34244204
51GnRH signaling pathway_Homo sapiens_hsa049121.32211639
52Vibrio cholerae infection_Homo sapiens_hsa051101.31391244
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29005607
54Chronic myeloid leukemia_Homo sapiens_hsa052201.28946925
55Estrogen signaling pathway_Homo sapiens_hsa049151.25567548
56Hippo signaling pathway_Homo sapiens_hsa043901.24333371
57Selenocompound metabolism_Homo sapiens_hsa004501.23809067
58Pentose phosphate pathway_Homo sapiens_hsa000301.23612322
59RNA polymerase_Homo sapiens_hsa030201.22851001
60Glioma_Homo sapiens_hsa052141.22156915
61Carbon metabolism_Homo sapiens_hsa012001.20554763
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18939859
63MicroRNAs in cancer_Homo sapiens_hsa052061.17289599
64Calcium signaling pathway_Homo sapiens_hsa040201.16732435
65Axon guidance_Homo sapiens_hsa043601.13409660
66Pyrimidine metabolism_Homo sapiens_hsa002401.13294602
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13054810
68cAMP signaling pathway_Homo sapiens_hsa040241.11195857
69Oxytocin signaling pathway_Homo sapiens_hsa049211.10195275
70Sulfur relay system_Homo sapiens_hsa041221.09902071
71cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09558408
72Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08738294
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.06346433
74Fanconi anemia pathway_Homo sapiens_hsa034601.05938410
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05800211
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05570264
77Collecting duct acid secretion_Homo sapiens_hsa049661.02528080
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01874702
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01494122
80Pyruvate metabolism_Homo sapiens_hsa006201.01205967
81Gap junction_Homo sapiens_hsa045400.99094639
82Pancreatic secretion_Homo sapiens_hsa049720.95401770
83Thyroid hormone synthesis_Homo sapiens_hsa049180.95272878
84Colorectal cancer_Homo sapiens_hsa052100.94758809
85Notch signaling pathway_Homo sapiens_hsa043300.93607003
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93284199
87Bladder cancer_Homo sapiens_hsa052190.92960417
88Dilated cardiomyopathy_Homo sapiens_hsa054140.91644110
89Dorso-ventral axis formation_Homo sapiens_hsa043200.90663393
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.89963383
91Melanogenesis_Homo sapiens_hsa049160.89860594
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88902673
93ECM-receptor interaction_Homo sapiens_hsa045120.88193501
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87915844
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87684229
96Circadian rhythm_Homo sapiens_hsa047100.86256701
97Tight junction_Homo sapiens_hsa045300.86032936
98ErbB signaling pathway_Homo sapiens_hsa040120.85971562
99Arginine biosynthesis_Homo sapiens_hsa002200.85168653
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.84606764
101Oocyte meiosis_Homo sapiens_hsa041140.84153310
102Glucagon signaling pathway_Homo sapiens_hsa049220.84053878
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83711990
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83612796
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83193093
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82997755
107Basal transcription factors_Homo sapiens_hsa030220.81987079
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81851564
109Inositol phosphate metabolism_Homo sapiens_hsa005620.81639466
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.81471592
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81389871
112Butanoate metabolism_Homo sapiens_hsa006500.80414295
113Pancreatic cancer_Homo sapiens_hsa052120.80211132
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80107062
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79483259
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.79479754
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.79001768
118N-Glycan biosynthesis_Homo sapiens_hsa005100.78559926
119TGF-beta signaling pathway_Homo sapiens_hsa043500.78150463
120Small cell lung cancer_Homo sapiens_hsa052220.76513281
121Folate biosynthesis_Homo sapiens_hsa007900.76485134
122MAPK signaling pathway_Homo sapiens_hsa040100.74268992
123Rap1 signaling pathway_Homo sapiens_hsa040150.73973390
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73573130
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72730538
126Prostate cancer_Homo sapiens_hsa052150.72335920
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67498206
128Choline metabolism in cancer_Homo sapiens_hsa052310.67322377
129Prion diseases_Homo sapiens_hsa050200.67100925
130p53 signaling pathway_Homo sapiens_hsa041150.66905000
131Purine metabolism_Homo sapiens_hsa002300.64591337
132Galactose metabolism_Homo sapiens_hsa000520.64122552
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62563493
134Lysosome_Homo sapiens_hsa041420.61567305
135Protein digestion and absorption_Homo sapiens_hsa049740.61407647
136Fructose and mannose metabolism_Homo sapiens_hsa000510.61005463
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60500567
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60255034
139Endometrial cancer_Homo sapiens_hsa052130.60098465
140Non-small cell lung cancer_Homo sapiens_hsa052230.57238434
141VEGF signaling pathway_Homo sapiens_hsa043700.57049654
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57043854
143Ras signaling pathway_Homo sapiens_hsa040140.55762441
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55639610
145Bile secretion_Homo sapiens_hsa049760.54885973
146Arginine and proline metabolism_Homo sapiens_hsa003300.53804699
147RNA degradation_Homo sapiens_hsa030180.53680112
148Wnt signaling pathway_Homo sapiens_hsa043100.53345177
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52784250
150Insulin signaling pathway_Homo sapiens_hsa049100.52254340
151mTOR signaling pathway_Homo sapiens_hsa041500.51304076
152Focal adhesion_Homo sapiens_hsa045100.50794325
153Endocytosis_Homo sapiens_hsa041440.50326896
154Pathways in cancer_Homo sapiens_hsa052000.50136557
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50073285
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49421225
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.49109507
158Proteoglycans in cancer_Homo sapiens_hsa052050.46670269
159Insulin resistance_Homo sapiens_hsa049310.46544628
160FoxO signaling pathway_Homo sapiens_hsa040680.45969151
161AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45846492
162Acute myeloid leukemia_Homo sapiens_hsa052210.44012264
163Steroid biosynthesis_Homo sapiens_hsa001000.43813355
164AMPK signaling pathway_Homo sapiens_hsa041520.43346890
165Melanoma_Homo sapiens_hsa052180.41565729
166Prolactin signaling pathway_Homo sapiens_hsa049170.40492435
167Lysine degradation_Homo sapiens_hsa003100.40466895
168Renal cell carcinoma_Homo sapiens_hsa052110.39519183
169Phenylalanine metabolism_Homo sapiens_hsa003600.38385661
170Viral carcinogenesis_Homo sapiens_hsa052030.37881769
171Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37534266
172Cardiac muscle contraction_Homo sapiens_hsa042600.37518937
173Hedgehog signaling pathway_Homo sapiens_hsa043400.37472449

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