ANKRD60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.70823914
2spermatid development (GO:0007286)9.60528601
3motile cilium assembly (GO:0044458)9.26761741
4cilium movement (GO:0003341)8.48772412
5regulation of cilium movement (GO:0003352)8.34703930
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.84581595
7sperm capacitation (GO:0048240)7.70317451
8male meiosis (GO:0007140)7.58670496
9single fertilization (GO:0007338)7.46304591
10piRNA metabolic process (GO:0034587)7.42848236
11synaptonemal complex organization (GO:0070193)7.38277838
12synaptonemal complex assembly (GO:0007130)7.34457465
13negative regulation of inclusion body assembly (GO:0090084)6.71250379
14spermatogenesis (GO:0007283)6.45002867
15male gamete generation (GO:0048232)6.42658778
16fertilization (GO:0009566)6.26986300
17organic cation transport (GO:0015695)6.25957924
18microtubule depolymerization (GO:0007019)6.12899354
19gamete generation (GO:0007276)5.90877781
20regulation of inclusion body assembly (GO:0090083)5.60848845
21spermatid nucleus differentiation (GO:0007289)5.52842267
22calcium ion-dependent exocytosis (GO:0017156)5.41531226
23ventricular system development (GO:0021591)5.39353649
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.38192282
25germ cell development (GO:0007281)5.35304450
26cell recognition (GO:0008037)5.15659979
27chromosome organization involved in meiosis (GO:0070192)5.05563530
28microtubule severing (GO:0051013)5.05396693
29regulation of microtubule-based movement (GO:0060632)4.90937447
30male meiosis I (GO:0007141)4.76269112
31DNA methylation involved in gamete generation (GO:0043046)4.71175424
32glycerol ether metabolic process (GO:0006662)4.69965801
33multicellular organismal reproductive process (GO:0048609)4.65175943
34chromosome condensation (GO:0030261)4.58534358
35seminiferous tubule development (GO:0072520)4.47189797
36meiotic nuclear division (GO:0007126)4.39842341
37DNA packaging (GO:0006323)4.34847486
38ether metabolic process (GO:0018904)4.34330434
39left/right pattern formation (GO:0060972)4.16777189
40sexual reproduction (GO:0019953)4.11788581
41single strand break repair (GO:0000012)4.04416179
42chaperone-mediated protein complex assembly (GO:0051131)3.90046399
43protein polyglutamylation (GO:0018095)3.83418017
44meiosis I (GO:0007127)3.78719162
45monoubiquitinated protein deubiquitination (GO:0035520)3.76533668
46multicellular organismal development (GO:0007275)3.75615563
47protein K11-linked deubiquitination (GO:0035871)3.71395599
48genitalia morphogenesis (GO:0035112)3.68654893
49meiotic cell cycle (GO:0051321)3.44957746
50protein localization to cilium (GO:0061512)3.40326724
51sequestering of actin monomers (GO:0042989)3.20819779
52regulation of spindle checkpoint (GO:0090231)3.19274238
53microtubule polymerization or depolymerization (GO:0031109)3.12074894
54carnitine transport (GO:0015879)3.10880852
55amino-acid betaine transport (GO:0015838)3.10880852
56protein refolding (GO:0042026)3.05319930
57glycolytic process (GO:0006096)3.02288250
58intraciliary transport (GO:0042073)3.00706521
59nucleoside diphosphate phosphorylation (GO:0006165)2.97957012
60carnitine transmembrane transport (GO:1902603)2.97705927
61synapsis (GO:0007129)2.97563480
62nucleus organization (GO:0006997)2.94808399
63microtubule-based movement (GO:0007018)2.93838523
64polyol catabolic process (GO:0046174)2.93586591
65cilium organization (GO:0044782)2.92746122
66alditol metabolic process (GO:0019400)2.92484288
67positive regulation of macrophage activation (GO:0043032)2.90048619
68meiotic cell cycle process (GO:1903046)2.84739400
69cilium assembly (GO:0042384)2.80802941
70GTP biosynthetic process (GO:0006183)2.80738807
71cellular component assembly involved in morphogenesis (GO:0010927)2.80522663
72negative regulation of organelle assembly (GO:1902116)2.78339357
73mitotic sister chromatid cohesion (GO:0007064)2.76398770
74lactate metabolic process (GO:0006089)2.71281213
75cilium morphogenesis (GO:0060271)2.70376639
76axoneme assembly (GO:0035082)2.70026229
77interferon-gamma secretion (GO:0072643)2.69839304
78gene silencing by RNA (GO:0031047)2.67494093
79centriole assembly (GO:0098534)2.61703103
80peptidyl-glutamic acid modification (GO:0018200)2.58276535
81glycerol metabolic process (GO:0006071)2.50337637
82UTP biosynthetic process (GO:0006228)2.50315645
83polyamine biosynthetic process (GO:0006596)2.45159656
84regulation of cilium assembly (GO:1902017)2.45003312
85chromatin silencing (GO:0006342)2.41802149
86regulation of centriole replication (GO:0046599)2.41289651
87sperm motility (GO:0030317)13.7368018
88fusion of sperm to egg plasma membrane (GO:0007342)13.6533358
89cell wall macromolecule catabolic process (GO:0016998)13.6362333
90cell wall macromolecule metabolic process (GO:0044036)13.6362333
91acrosome assembly (GO:0001675)12.4509902
92sperm-egg recognition (GO:0035036)11.8934336
93acrosome reaction (GO:0007340)11.6872530
94multicellular organism reproduction (GO:0032504)11.3054829
95binding of sperm to zona pellucida (GO:0007339)10.7891640
96cell-cell recognition (GO:0009988)10.6579841
97cilium or flagellum-dependent cell motility (GO:0001539)10.6066203
98plasma membrane fusion (GO:0045026)10.3978638
99epithelial cilium movement (GO:0003351)10.1705357
100axonemal dynein complex assembly (GO:0070286)10.0640350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.54774028
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63801771
3EZH2_22144423_ChIP-Seq_EOC_Human4.19937057
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23515268
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08693949
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.78442243
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.49008996
8VDR_22108803_ChIP-Seq_LS180_Human2.30248449
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.27740139
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21512520
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.15645082
12ZNF274_21170338_ChIP-Seq_K562_Hela2.08228712
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07465258
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.03502683
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.03229076
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01035719
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.92017859
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78318896
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76204608
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72853420
21STAT1_17558387_ChIP-Seq_HELA_Human1.68795556
22RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.68472196
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.64060790
24FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63022154
25KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58975622
26GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58565308
27GATA3_21867929_ChIP-Seq_CD8_Mouse1.55651860
28SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55451455
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52560366
30KDM2B_26808549_Chip-Seq_REH_Human1.51430276
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51170688
32TAL1_26923725_Chip-Seq_HPCs_Mouse1.50174031
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.45693626
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44917488
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.42654502
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42406723
37CBP_20019798_ChIP-Seq_JUKART_Human1.42406723
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33891360
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33373419
40LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31716106
41FLI1_21867929_ChIP-Seq_TH2_Mouse1.30955301
42PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29747996
43GATA3_21867929_ChIP-Seq_TH1_Mouse1.29084411
44P53_21459846_ChIP-Seq_SAOS-2_Human1.27346644
45REST_21632747_ChIP-Seq_MESCs_Mouse1.26560710
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25684237
47FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25269218
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24822561
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20731230
50CRX_20693478_ChIP-Seq_RETINA_Mouse1.19407215
51TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18922880
52CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18172713
53GF1_26923725_Chip-Seq_HPCs_Mouse1.18039732
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.17544709
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.15477484
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13980210
57RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13231245
58SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.11751673
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11686968
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11686968
61RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10865288
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10571733
63P53_22387025_ChIP-Seq_ESCs_Mouse1.09180768
64SPI1_26923725_Chip-Seq_HPCs_Mouse1.09059931
65CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08641374
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.06935290
67CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06826259
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05862341
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05352653
70ESET_19884257_ChIP-Seq_ESCs_Mouse1.05300994
71P300_18555785_Chip-Seq_ESCs_Mouse1.04738848
72RNF2_27304074_Chip-Seq_NSC_Mouse1.04378051
73KLF4_18555785_Chip-Seq_ESCs_Mouse1.03732136
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02959380
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01691455
76ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01012925
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00845296
78SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00691956
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00347047
80ERG_20517297_ChIP-Seq_VCAP_Human1.00144161
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.99541584
82RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98701270
83RARA_24833708_ChIP-Seq_LIVER_Mouse0.98414467
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97665436
85SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96623339
86EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96527773
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96339014
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95452924
89MYC_27129775_Chip-Seq_CORNEA_Mouse0.94305239
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.93320519
91LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93163884
92STAT3_18555785_Chip-Seq_ESCs_Mouse0.91951122
93SOX2_18555785_Chip-Seq_ESCs_Mouse0.90508754
94NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90205197
95SOX9_26525672_Chip-Seq_HEART_Mouse0.88961511
96GF1B_26923725_Chip-Seq_HPCs_Mouse0.88654695
97PU1_27457419_Chip-Seq_LIVER_Mouse0.88583189
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88581131
99FLI1_21867929_ChIP-Seq_CD8_Mouse0.88441070
100TAF15_26573619_Chip-Seq_HEK293_Human0.88071839

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.13197695
2MP0001929_abnormal_gametogenesis5.60110463
3MP0008877_abnormal_DNA_methylation4.19578069
4MP0002210_abnormal_sex_determination3.48378823
5MP0002161_abnormal_fertility/fecundity3.32065716
6MP0001145_abnormal_male_reproductive2.97601316
7MP0002653_abnormal_ependyma_morphology2.79497783
8MP0000653_abnormal_sex_gland2.57854398
9MP0005670_abnormal_white_adipose2.51735073
10MP0005410_abnormal_fertilization16.3837955
11MP0005623_abnormal_meninges_morphology1.94674783
12MP0002160_abnormal_reproductive_system1.46827359
13MP0003646_muscle_fatigue1.38689152
14MP0004233_abnormal_muscle_weight1.37661904
15MP0002282_abnormal_trachea_morphology1.31794217
16MP0008058_abnormal_DNA_repair1.21473204
17MP0009046_muscle_twitch1.19425789
18MP0001765_abnormal_ion_homeostasis1.13554177
19MP0001984_abnormal_olfaction0.99452050
20MP0005647_abnormal_sex_gland0.95213999
21MP0002234_abnormal_pharynx_morphology0.80007172
22MP0005389_reproductive_system_phenotype0.75806655
23MP0003011_delayed_dark_adaptation0.73316867
24MP0008995_early_reproductive_senescence0.69069590
25MP0010094_abnormal_chromosome_stability0.68352321
26MP0000569_abnormal_digit_pigmentation0.64919713
27MP0008057_abnormal_DNA_replication0.64612406
28MP0005636_abnormal_mineral_homeostasis0.64494068
29MP0005377_hearing/vestibular/ear_phenot0.55980203
30MP0003878_abnormal_ear_physiology0.55980203
31MP0004036_abnormal_muscle_relaxation0.53276964
32MP0003115_abnormal_respiratory_system0.53245782
33MP0001324_abnormal_eye_pigmentation0.52525882
34MP0002928_abnormal_bile_duct0.51721663
35MP0000358_abnormal_cell_content/0.50610610
36MP0001293_anophthalmia0.49491356
37MP0003699_abnormal_female_reproductive0.48284038
38MP0003950_abnormal_plasma_membrane0.46290817
39MP0005666_abnormal_adipose_tissue0.45610957
40MP0001764_abnormal_homeostasis0.44998348
41MP0002736_abnormal_nociception_after0.41726090
42MP0005397_hematopoietic_system_phenotyp0.41400988
43MP0001545_abnormal_hematopoietic_system0.41400988
44MP0002269_muscular_atrophy0.40765424
45MP0005253_abnormal_eye_physiology0.40506591
46MP0003329_amyloid_beta_deposits0.40405173
47MP0005551_abnormal_eye_electrophysiolog0.40177475
48MP0004019_abnormal_vitamin_homeostasis0.39396089
49MP0004133_heterotaxia0.38347004
50MP0006036_abnormal_mitochondrial_physio0.37640079
51MP0009278_abnormal_bone_marrow0.34127931
52MP0001119_abnormal_female_reproductive0.32528720
53MP0008007_abnormal_cellular_replicative0.32504637
54MP0003633_abnormal_nervous_system0.32383102
55MP0003786_premature_aging0.31561582
56MP0005391_vision/eye_phenotype0.31526913
57MP0009115_abnormal_fat_cell0.31275231
58MP0002971_abnormal_brown_adipose0.30663459
59MP0003111_abnormal_nucleus_morphology0.30156317
60MP0010307_abnormal_tumor_latency0.29706409
61MP0003879_abnormal_hair_cell0.27814203
62MP0002139_abnormal_hepatobiliary_system0.27615202
63MP0002102_abnormal_ear_morphology0.27025284
64MP0001730_embryonic_growth_arrest0.26266448
65MP0004811_abnormal_neuron_physiology0.25214256
66MP0000534_abnormal_ureter_morphology0.24123344
67MP0003631_nervous_system_phenotype0.23604125
68MP0003861_abnormal_nervous_system0.22722097
69MP0001968_abnormal_touch/_nociception0.21203952
70MP0002152_abnormal_brain_morphology0.20527117
71MP0000313_abnormal_cell_death0.20205610
72MP0004808_abnormal_hematopoietic_stem0.20192966
73MP0000604_amyloidosis0.19848946
74MP0002169_no_abnormal_phenotype0.19762575
75MP0002873_normal_phenotype0.19509059
76MP0002132_abnormal_respiratory_system0.18547255
77MP0005174_abnormal_tail_pigmentation0.18127738
78MP0006035_abnormal_mitochondrial_morpho0.17234501
79MP0002092_abnormal_eye_morphology0.17017389
80MP0003948_abnormal_gas_homeostasis0.16941658
81MP0004043_abnormal_pH_regulation0.16400171
82MP0002229_neurodegeneration0.15879419
83MP0004742_abnormal_vestibular_system0.15699546
84MP0004145_abnormal_muscle_electrophysio0.15290690
85MP0002084_abnormal_developmental_patter0.15010771
86MP0002405_respiratory_system_inflammati0.14927214
87MP0008875_abnormal_xenobiotic_pharmacok0.14892170
88MP0004084_abnormal_cardiac_muscle0.14529284
89MP0003942_abnormal_urinary_system0.14517348
90MP0005319_abnormal_enzyme/_coenzyme0.13784125
91MP0004134_abnormal_chest_morphology0.13752552
92MP0000462_abnormal_digestive_system0.13703088
93MP0003787_abnormal_imprinting0.13577130
94MP0002295_abnormal_pulmonary_circulatio0.13077371
95MP0000001_mammalian_phenotype0.12745876
96MP0005365_abnormal_bile_salt0.12740427
97MP0005195_abnormal_posterior_eye0.12360041
98MP0002693_abnormal_pancreas_physiology0.11957115
99MP0006072_abnormal_retinal_apoptosis0.10902078
100MP0009697_abnormal_copulation0.10894791

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.62437484
2Abnormal respiratory epithelium morphology (HP:0012253)9.11248353
3Abnormal respiratory motile cilium morphology (HP:0005938)9.11248353
4Abnormal ciliary motility (HP:0012262)7.78240110
5Rhinitis (HP:0012384)7.77056690
6Chronic bronchitis (HP:0004469)7.49232026
7Infertility (HP:0000789)6.66045102
8Nasal polyposis (HP:0100582)6.53325565
9Abnormality of the nasal mucosa (HP:0000433)5.36615619
10Bronchitis (HP:0012387)4.72897019
11Bronchiectasis (HP:0002110)4.58967257
12Male infertility (HP:0003251)4.30499617
13Nephronophthisis (HP:0000090)4.19216145
14Recurrent sinusitis (HP:0011108)3.48210333
15Abnormal spermatogenesis (HP:0008669)3.42891823
16Recurrent otitis media (HP:0000403)3.38682826
17Abnormality of the renal medulla (HP:0100957)3.17447766
18Recurrent bronchitis (HP:0002837)2.88673680
19Tubulointerstitial nephritis (HP:0001970)2.79060455
20Abnormality of midbrain morphology (HP:0002418)2.64372174
21Molar tooth sign on MRI (HP:0002419)2.64372174
22Medial flaring of the eyebrow (HP:0010747)2.56322468
23Tubular atrophy (HP:0000092)2.54327229
24Tubulointerstitial abnormality (HP:0001969)2.39789022
25Impulsivity (HP:0100710)2.37529490
26Azoospermia (HP:0000027)2.30769688
27Gonadotropin excess (HP:0000837)2.25551039
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7737508
29Absent/shortened dynein arms (HP:0200106)13.1501815
30Dynein arm defect of respiratory motile cilia (HP:0012255)13.1501815
31Abnormal gallbladder physiology (HP:0012438)1.99688040
32Cholecystitis (HP:0001082)1.99688040
33Postaxial foot polydactyly (HP:0001830)1.94672768
34Dyschromatopsia (HP:0007641)1.94434693
35Tubulointerstitial fibrosis (HP:0005576)1.93924857
36Decreased central vision (HP:0007663)1.83516667
37Congenital hepatic fibrosis (HP:0002612)1.80563009
38Abnormality of the lower motor neuron (HP:0002366)1.78748231
39Stage 5 chronic kidney disease (HP:0003774)1.77816760
40Fibular hypoplasia (HP:0003038)1.77451498
41Polydipsia (HP:0001959)1.72439660
42Abnormal drinking behavior (HP:0030082)1.72439660
43Abnormality of the renal cortex (HP:0011035)1.68874021
44Abnormal biliary tract physiology (HP:0012439)1.68449913
45Bile duct proliferation (HP:0001408)1.68449913
46Spastic tetraparesis (HP:0001285)1.67853498
47Short ribs (HP:0000773)1.64124804
48Abnormality of renal excretion (HP:0011036)1.63523709
49Abnormality of permanent molar morphology (HP:0011071)1.60003927
50Abnormality of the dental root (HP:0006486)1.60003927
51Taurodontia (HP:0000679)1.60003927
52Hypoplasia of the capital femoral epiphysis (HP:0003090)1.59877582
53Chronic sinusitis (HP:0011109)1.57201616
54Microglossia (HP:0000171)1.56482933
55Oculomotor apraxia (HP:0000657)1.56165618
56Renal dysplasia (HP:0000110)1.53858082
57Facial cleft (HP:0002006)1.53420138
58Pancreatic fibrosis (HP:0100732)1.52790325
59Heterotopia (HP:0002282)1.52775154
60Postaxial hand polydactyly (HP:0001162)1.50398568
61Abnormality of molar (HP:0011077)1.49783695
62Abnormality of molar morphology (HP:0011070)1.49783695
63Absent frontal sinuses (HP:0002688)1.49653725
64Choroideremia (HP:0001139)1.49184562
65Amyotrophic lateral sclerosis (HP:0007354)1.48034812
66Cystic liver disease (HP:0006706)1.47725755
67Abnormality of the dental pulp (HP:0006479)1.47616039
68Abnormality of dentin (HP:0010299)1.45224355
69Congenital primary aphakia (HP:0007707)1.44230805
70Gait imbalance (HP:0002141)1.43633623
71Asymmetric septal hypertrophy (HP:0001670)1.43123137
72Bell-shaped thorax (HP:0001591)1.42290950
73Aplasia/Hypoplasia of the lens (HP:0008063)1.41785810
74Congenital malformation of the right heart (HP:0011723)1.39900052
75Double outlet right ventricle (HP:0001719)1.39900052
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.38601343
77J-shaped sella turcica (HP:0002680)1.38413126
78Deformed sella turcica (HP:0002681)1.35892319
79Bundle branch block (HP:0011710)1.35157453
80Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32179590
81Hemorrhage of the eye (HP:0011885)1.32108369
82Median cleft lip (HP:0000161)1.30270451
83Abnormal urine output (HP:0012590)1.29534012
84Abnormality of saccadic eye movements (HP:0000570)1.28222909
85Abnormality of ocular smooth pursuit (HP:0000617)1.26652978
86Impaired proprioception (HP:0010831)1.25565151
87Constricted visual fields (HP:0001133)1.25053777
88Absent epiphyses (HP:0010577)1.24848543
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.24848543
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24594842
91Short thorax (HP:0010306)1.22827202
92Nephrogenic diabetes insipidus (HP:0009806)1.21393519
93Neurofibrillary tangles (HP:0002185)1.21194998
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.20453587
95Cerebellar dysplasia (HP:0007033)1.20272595
96Nephropathy (HP:0000112)1.19732561
97True hermaphroditism (HP:0010459)1.19509666
98Vascular calcification (HP:0004934)1.18996561
99Exercise-induced myalgia (HP:0003738)1.18135507
100Tongue fasciculations (HP:0001308)1.17152699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.82439169
2PDK48.82439169
3PDK25.72381725
4TESK15.45453454
5PRKD34.15467550
6ICK3.74033661
7WNK42.32160292
8PTK2B2.27539028
9STK392.26912791
10PNCK1.75791626
11STK381.68391455
12NEK21.53084743
13DYRK1B1.35652252
14PDK11.18171123
15CCNB10.84914647
16WNK10.84640872
17DYRK30.83376866
18MAPK150.81682511
19IRAK10.80407251
20TYRO30.80198351
21LMTK20.76558927
22PASK0.74055317
23STK30.68429764
24PDPK10.66330441
25TTK0.64119236
26STK38L0.58458013
27CHEK20.57662731
28RIPK40.55139392
29PINK10.53346431
30MAP2K60.52422805
31EEF2K0.50469866
32WEE10.50038249
33TESK20.45754086
34BRSK20.45559837
35CHEK10.40993797
36IRAK20.40699938
37CAMK1G0.37338430
38NTRK20.36475941
39MUSK0.34369765
40PAK10.33689003
41ATR0.32502175
42PRKCG0.31609680
43PLK40.28129446
44ATM0.27490611
45MAP3K100.26562467
46CDC70.25691496
47MAPKAPK50.23929919
48MTOR0.21736112
49PAK20.21226004
50CAMKK10.20996182
51NEK60.20329456
52BRSK10.18666646
53PLK10.18341720
54MARK20.18114937
55PRKAA10.17317962
56PRKCZ0.15988258
57RPS6KB10.15758968
58PRKCQ0.15663831
59PRKG20.13905264
60ZAP700.12412658
61MAP2K70.12392720
62CDK150.11110420
63MARK30.10227066
64PAK40.08874876
65CDK180.08461976
66CDK11A0.08147384
67MAP3K40.08121613
68CSNK2A10.07743940
69PDGFRB0.07512523
70STK100.06749830
71RIPK10.06700250
72RPS6KA10.06343752
73BRAF0.06306937
74GSK3B0.05627607
75PRKG10.05204612
76STK110.04594289
77PRKACG0.04572764
78BMPR1B0.04303039
79CDK140.04294011
80CSNK2A20.04089442
81CDK10.03828556
82YES10.03514323
83MAPK80.02984216
84CDK20.02862569
85PKN10.02769648
86CSF1R0.02353756
87CAMK2A0.01813488
88CSNK1D0.01787218
89PRKCD0.01120502
90CDK120.01087126
91PRKCA0.00336682
92PRKCB0.00179319
93PIM10.00070221
94EGFR0.00063088
95MAP3K5-0.0229838
96CDK6-0.0203636
97PRKACB-0.0151055
98AURKA-0.0138685
99PRKDC-0.0110902
100WNK3-0.0077928

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.45514382
2Fatty acid biosynthesis_Homo sapiens_hsa000614.16387892
3Vitamin B6 metabolism_Homo sapiens_hsa007503.90501083
4Pyruvate metabolism_Homo sapiens_hsa006203.67313450
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.02088139
6Linoleic acid metabolism_Homo sapiens_hsa005912.91945109
7Propanoate metabolism_Homo sapiens_hsa006402.80623433
8Glucagon signaling pathway_Homo sapiens_hsa049222.64851748
9Basal transcription factors_Homo sapiens_hsa030222.50432427
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41381192
11Pentose phosphate pathway_Homo sapiens_hsa000302.40816934
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.13014151
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99144689
14Selenocompound metabolism_Homo sapiens_hsa004501.97809859
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.95833330
16Glycerolipid metabolism_Homo sapiens_hsa005611.94113752
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.84257626
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.78704538
19PPAR signaling pathway_Homo sapiens_hsa033201.74653005
20Oocyte meiosis_Homo sapiens_hsa041141.73876564
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70291117
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.61167045
23Fanconi anemia pathway_Homo sapiens_hsa034601.60702031
24Dorso-ventral axis formation_Homo sapiens_hsa043201.54959705
25Fructose and mannose metabolism_Homo sapiens_hsa000511.54866933
26Carbon metabolism_Homo sapiens_hsa012001.51246972
27Amphetamine addiction_Homo sapiens_hsa050311.45034431
28Mineral absorption_Homo sapiens_hsa049781.43100972
29Fat digestion and absorption_Homo sapiens_hsa049751.42332621
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.42122422
31Ether lipid metabolism_Homo sapiens_hsa005651.33999502
32Huntingtons disease_Homo sapiens_hsa050161.32956908
33Cardiac muscle contraction_Homo sapiens_hsa042601.31333344
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29503057
35Fatty acid degradation_Homo sapiens_hsa000711.26325914
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.23279629
37Fatty acid metabolism_Homo sapiens_hsa012121.22715713
38Renin secretion_Homo sapiens_hsa049241.11324403
39Purine metabolism_Homo sapiens_hsa002301.06471721
40Biosynthesis of amino acids_Homo sapiens_hsa012301.05467977
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03955127
42Antigen processing and presentation_Homo sapiens_hsa046121.03219322
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.00607569
44mRNA surveillance pathway_Homo sapiens_hsa030151.00273185
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94672901
46Renin-angiotensin system_Homo sapiens_hsa046140.93028960
47Glutathione metabolism_Homo sapiens_hsa004800.92887274
48RNA transport_Homo sapiens_hsa030130.82668588
49Chemical carcinogenesis_Homo sapiens_hsa052040.79999406
50Collecting duct acid secretion_Homo sapiens_hsa049660.79148796
51Arachidonic acid metabolism_Homo sapiens_hsa005900.77964940
52Insulin secretion_Homo sapiens_hsa049110.73103858
53Hedgehog signaling pathway_Homo sapiens_hsa043400.70776048
54ABC transporters_Homo sapiens_hsa020100.70246676
55Thyroid hormone synthesis_Homo sapiens_hsa049180.68586667
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67052855
57Long-term potentiation_Homo sapiens_hsa047200.66811906
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.65175912
59Bile secretion_Homo sapiens_hsa049760.65158315
60Estrogen signaling pathway_Homo sapiens_hsa049150.65073206
61Systemic lupus erythematosus_Homo sapiens_hsa053220.60084402
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59883591
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.55443774
64Legionellosis_Homo sapiens_hsa051340.54794598
65Calcium signaling pathway_Homo sapiens_hsa040200.53597025
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53560335
67Pancreatic secretion_Homo sapiens_hsa049720.52039457
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51404424
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50268790
70Inositol phosphate metabolism_Homo sapiens_hsa005620.47993173
71Sulfur metabolism_Homo sapiens_hsa009200.47754623
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46705936
73Protein digestion and absorption_Homo sapiens_hsa049740.45534789
74AMPK signaling pathway_Homo sapiens_hsa041520.43856837
75Endocytosis_Homo sapiens_hsa041440.42607736
76Metabolic pathways_Homo sapiens_hsa011000.41653880
77Salivary secretion_Homo sapiens_hsa049700.41458290
78Gastric acid secretion_Homo sapiens_hsa049710.37816825
79Synaptic vesicle cycle_Homo sapiens_hsa047210.36326303
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.34845437
81Taste transduction_Homo sapiens_hsa047420.34784443
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31980762
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30764970
84VEGF signaling pathway_Homo sapiens_hsa043700.30071182
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26542103
86cAMP signaling pathway_Homo sapiens_hsa040240.24445881
87Pyrimidine metabolism_Homo sapiens_hsa002400.24417576
88N-Glycan biosynthesis_Homo sapiens_hsa005100.21284512
89Alcoholism_Homo sapiens_hsa050340.19959600
90Circadian entrainment_Homo sapiens_hsa047130.19340696
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16227004
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15413941
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14129717
94Cocaine addiction_Homo sapiens_hsa050300.13912875
95Salmonella infection_Homo sapiens_hsa051320.10934315
96Homologous recombination_Homo sapiens_hsa034400.10154684
97Wnt signaling pathway_Homo sapiens_hsa043100.09538417
98Retinol metabolism_Homo sapiens_hsa008300.08851975
99B cell receptor signaling pathway_Homo sapiens_hsa046620.08803864
100Viral carcinogenesis_Homo sapiens_hsa052030.08099670

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