ANKRD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.00237911
2pyrimidine nucleobase catabolic process (GO:0006208)4.80626815
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.63830329
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.46441365
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.44604738
6synaptic vesicle maturation (GO:0016188)4.27325742
7neuron cell-cell adhesion (GO:0007158)4.26624201
8synaptic vesicle exocytosis (GO:0016079)4.23728190
9vocalization behavior (GO:0071625)4.22523215
10layer formation in cerebral cortex (GO:0021819)4.22003359
11regulation of glutamate receptor signaling pathway (GO:1900449)4.21050224
12axon ensheathment in central nervous system (GO:0032291)4.17433296
13central nervous system myelination (GO:0022010)4.17433296
14protein localization to synapse (GO:0035418)4.17034107
15presynaptic membrane assembly (GO:0097105)4.11103993
16locomotory exploration behavior (GO:0035641)4.09871310
17presynaptic membrane organization (GO:0097090)4.06923118
18glutamate secretion (GO:0014047)4.00179368
19regulation of synaptic vesicle exocytosis (GO:2000300)3.97144913
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.90784374
21nucleobase catabolic process (GO:0046113)3.87187152
22neurotransmitter-gated ion channel clustering (GO:0072578)3.85192224
23cell migration in hindbrain (GO:0021535)3.84894233
24regulation of synapse structural plasticity (GO:0051823)3.82990926
25regulation of synaptic vesicle transport (GO:1902803)3.74124928
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.74009380
27negative regulation of oligodendrocyte differentiation (GO:0048715)3.73542785
28neurotransmitter secretion (GO:0007269)3.70990387
29positive regulation of synaptic transmission, GABAergic (GO:0032230)3.70052848
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.68016229
31cellular potassium ion homeostasis (GO:0030007)3.65652259
32synaptic vesicle endocytosis (GO:0048488)3.59370441
33gamma-aminobutyric acid transport (GO:0015812)3.53627790
34response to auditory stimulus (GO:0010996)3.49464480
35regulation of neuronal synaptic plasticity (GO:0048168)3.48987588
36proline transport (GO:0015824)3.48593172
37urinary tract smooth muscle contraction (GO:0014848)3.47051999
38axonal fasciculation (GO:0007413)3.45911478
39positive regulation of dendritic spine morphogenesis (GO:0061003)3.45699739
40dendritic spine morphogenesis (GO:0060997)3.40989807
41exploration behavior (GO:0035640)3.40321406
42neuron recognition (GO:0008038)3.37378400
43response to pheromone (GO:0019236)3.37203602
44positive regulation of synapse maturation (GO:0090129)3.34691247
45innervation (GO:0060384)3.34314577
46auditory behavior (GO:0031223)3.33577612
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30272370
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28627008
49long-term memory (GO:0007616)3.27525794
50synaptic transmission, glutamatergic (GO:0035249)3.26268332
51glutamate receptor signaling pathway (GO:0007215)3.26006346
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.25005296
53retinal ganglion cell axon guidance (GO:0031290)3.23556984
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.22928814
55G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22369365
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21081316
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20226340
58limb bud formation (GO:0060174)3.19089105
59neuronal stem cell maintenance (GO:0097150)3.16805738
60negative regulation of astrocyte differentiation (GO:0048712)3.14421686
61neuron-neuron synaptic transmission (GO:0007270)3.14181977
62neurotransmitter transport (GO:0006836)3.10900562
63cochlea development (GO:0090102)3.08975375
64positive regulation of gastrulation (GO:2000543)3.08843949
65regulation of respiratory system process (GO:0044065)3.06913075
66central nervous system projection neuron axonogenesis (GO:0021952)3.06587872
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.06464080
68behavioral defense response (GO:0002209)3.03944802
69behavioral fear response (GO:0001662)3.03944802
70otic vesicle formation (GO:0030916)3.00463468
71neuromuscular synaptic transmission (GO:0007274)2.99449686
72membrane hyperpolarization (GO:0060081)2.99412904
73behavioral response to ethanol (GO:0048149)2.99231703
74intraciliary transport (GO:0042073)2.98967355
75regulation of synaptic transmission, glutamatergic (GO:0051966)2.98228201
76epithelial cilium movement (GO:0003351)2.95880450
77prepulse inhibition (GO:0060134)2.94586496
78neuron fate determination (GO:0048664)2.93775467
79lateral sprouting from an epithelium (GO:0060601)2.91286732
80primitive streak formation (GO:0090009)2.90566474
81postsynaptic membrane organization (GO:0001941)2.90348277
82cilium movement (GO:0003341)2.87508109
83adult walking behavior (GO:0007628)2.87485657
84striatum development (GO:0021756)2.87049621
85regulation of vesicle fusion (GO:0031338)2.85849593
86cilium or flagellum-dependent cell motility (GO:0001539)2.85125867
87fear response (GO:0042596)2.84992881
88long-term synaptic potentiation (GO:0060291)2.84712625
89regulation of respiratory gaseous exchange (GO:0043576)2.84208536
90dendrite morphogenesis (GO:0048813)2.82483671
91regulation of neurotransmitter secretion (GO:0046928)2.81953923
92regulation of postsynaptic membrane potential (GO:0060078)2.81045808
93synapse assembly (GO:0007416)2.80670370
94regulation of dendritic spine morphogenesis (GO:0061001)2.80413260
95regulation of neurotransmitter levels (GO:0001505)2.80252463
96regulation of synapse maturation (GO:0090128)2.78634801
97somite development (GO:0061053)2.78278108
98dopamine receptor signaling pathway (GO:0007212)2.78157809
99adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.78089439
100behavioral response to nicotine (GO:0035095)2.77991199
101central nervous system neuron axonogenesis (GO:0021955)2.77200765
102positive regulation of membrane potential (GO:0045838)2.76964830
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76958054
104transmission of nerve impulse (GO:0019226)2.76680505
105regulation of neurotransmitter transport (GO:0051588)2.75913181
106behavioral response to cocaine (GO:0048148)2.75483051
107negative regulation of glial cell differentiation (GO:0045686)2.75167152
108dendrite development (GO:0016358)2.74090973
109regulation of synaptic transmission, GABAergic (GO:0032228)2.72445267
110mechanosensory behavior (GO:0007638)2.72153828
111cerebellar Purkinje cell differentiation (GO:0021702)2.72005709
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70843285
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68626108
114cerebral cortex neuron differentiation (GO:0021895)2.68076709
115cell communication by electrical coupling (GO:0010644)2.67783108
116negative regulation of microtubule polymerization (GO:0031115)2.67566202
117regulation of oligodendrocyte differentiation (GO:0048713)2.67053585
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66969159
119neuromuscular process controlling balance (GO:0050885)2.64931774
120establishment of nucleus localization (GO:0040023)2.64924094
121righting reflex (GO:0060013)2.64353570
122positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.63454822
123nonmotile primary cilium assembly (GO:0035058)2.63246612
124potassium ion homeostasis (GO:0055075)2.62431570
125positive regulation of potassium ion transmembrane transport (GO:1901381)2.62389992
126positive regulation of dendritic spine development (GO:0060999)2.62265995
127neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.61980719
128regulation of synaptic plasticity (GO:0048167)2.61220580
129positive regulation of synapse assembly (GO:0051965)2.61014510
130negative regulation of axon guidance (GO:1902668)2.60798383
131positive regulation of neurotransmitter transport (GO:0051590)2.59992259
132startle response (GO:0001964)2.58325355
133neuronal action potential (GO:0019228)2.58190119
134learning (GO:0007612)2.57901226
135serotonin metabolic process (GO:0042428)2.57435242
136establishment of synaptic vesicle localization (GO:0097480)2.56046640
137somite rostral/caudal axis specification (GO:0032525)2.55612142
138neuronal action potential propagation (GO:0019227)2.54054210
139forebrain neuron differentiation (GO:0021879)2.49455255
140inner ear receptor stereocilium organization (GO:0060122)2.48670316
141appendage development (GO:0048736)2.48216196
142limb development (GO:0060173)2.48216196
143spinal cord development (GO:0021510)2.47335859
144cerebral cortex radially oriented cell migration (GO:0021799)2.45820175
145negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.44428163
146regulation of axon guidance (GO:1902667)2.44013552
147cilium assembly (GO:0042384)2.42917359
148hindbrain development (GO:0030902)2.42682503
149cilium organization (GO:0044782)2.42585257
150cilium morphogenesis (GO:0060271)2.42433300
151cardiac right ventricle morphogenesis (GO:0003215)2.42060827
152smoothened signaling pathway (GO:0007224)2.40631752
153regulation of synapse assembly (GO:0051963)2.39257450
154membrane depolarization during action potential (GO:0086010)2.39216071
155neural tube formation (GO:0001841)2.37170379
156regulation of calcium ion-dependent exocytosis (GO:0017158)2.36724586
157ventricular system development (GO:0021591)2.32824986
158regulation of timing of cell differentiation (GO:0048505)2.32420087
159retinal cone cell development (GO:0046549)2.32099709
160axonemal dynein complex assembly (GO:0070286)2.32009921
161regulation of collateral sprouting (GO:0048670)2.31090962
162protein localization to cilium (GO:0061512)2.30595016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.56434711
2GBX2_23144817_ChIP-Seq_PC3_Human3.30217876
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73958762
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.73040728
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69891295
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62152235
7REST_21632747_ChIP-Seq_MESCs_Mouse2.58346449
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.47417395
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.44676071
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39298096
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36074639
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36074639
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34575559
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34365012
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.19920115
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.17574534
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16573590
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13175879
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13016560
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.04655937
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.01946522
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.00571477
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99159440
24DROSHA_22980978_ChIP-Seq_HELA_Human1.96450698
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96330941
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95178079
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94202132
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89998775
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86931832
30AR_21572438_ChIP-Seq_LNCaP_Human1.81377043
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.79832970
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77556088
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76820135
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74882735
35RNF2_27304074_Chip-Seq_NSC_Mouse1.73127773
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.72717461
37TAF15_26573619_Chip-Seq_HEK293_Human1.69332401
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68450751
39VDR_22108803_ChIP-Seq_LS180_Human1.66090899
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61782777
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61653985
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57787121
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56861547
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55066396
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54691406
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.52810353
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52003028
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49715603
49P300_19829295_ChIP-Seq_ESCs_Human1.47187987
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43159249
51IGF1R_20145208_ChIP-Seq_DFB_Human1.40000172
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38428142
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37101761
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.36811178
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.35733801
56CBP_20019798_ChIP-Seq_JUKART_Human1.35007484
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35007484
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31870700
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.28867095
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.28816221
61FUS_26573619_Chip-Seq_HEK293_Human1.28775706
62AR_25329375_ChIP-Seq_VCAP_Human1.28715395
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28606460
64* STAT3_23295773_ChIP-Seq_U87_Human1.27677700
65BCAT_22108803_ChIP-Seq_LS180_Human1.27233915
66ZNF274_21170338_ChIP-Seq_K562_Hela1.26516318
67* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25952009
68ER_23166858_ChIP-Seq_MCF-7_Human1.25736887
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.25707422
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25489201
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25489201
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24872329
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23777073
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.22559536
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22537265
76* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22281299
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.20412475
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19839814
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19359506
80AR_19668381_ChIP-Seq_PC3_Human1.18785658
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18159411
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17621563
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17442840
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.17297282
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17202858
86* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16960586
87* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16662501
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16608609
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16296068
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.15175988
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14383279
92* PIAS1_25552417_ChIP-Seq_VCAP_Human1.13787527
93* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13505560
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11135064
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10763781
96* SMAD3_21741376_ChIP-Seq_HESCs_Human1.09369962
97TCF4_22108803_ChIP-Seq_LS180_Human1.09094713
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08897534
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.07585327
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06714650
101TAL1_26923725_Chip-Seq_HPCs_Mouse1.05630079
102SMAD3_21741376_ChIP-Seq_ESCs_Human1.05037691
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.04868577
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04696752
105P53_22387025_ChIP-Seq_ESCs_Mouse1.03969105
106* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03792440
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03535817
108FLI1_21867929_ChIP-Seq_TH2_Mouse1.03531432
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03243261
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02695199
111* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02657532
112* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00810261
113EWS_26573619_Chip-Seq_HEK293_Human0.99975616
114* TCF4_23295773_ChIP-Seq_U87_Human0.99292278
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98119296
116POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97135049
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96750423
118TP63_19390658_ChIP-ChIP_HaCaT_Human0.96367765
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95392789
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95379313
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94958339
122* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94769303
123NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93756121
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93556136
125* RUNX2_22187159_ChIP-Seq_PCA_Human0.93425652
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91924967
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90331691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.31289050
2MP0003136_yellow_coat_color4.07448056
3MP0003880_abnormal_central_pattern3.87889777
4MP0003635_abnormal_synaptic_transmissio3.00129687
5MP0002822_catalepsy2.66280548
6MP0002063_abnormal_learning/memory/cond2.59056505
7MP0005646_abnormal_pituitary_gland2.55218342
8MP0002653_abnormal_ependyma_morphology2.50119292
9MP0005423_abnormal_somatic_nervous2.44774016
10MP0009745_abnormal_behavioral_response2.42442130
11MP0004270_analgesia2.41787771
12MP0001529_abnormal_vocalization2.30020774
13MP0002734_abnormal_mechanical_nocicepti2.25235784
14MP0005645_abnormal_hypothalamus_physiol2.22818767
15MP0000778_abnormal_nervous_system2.21515913
16MP0001968_abnormal_touch/_nociception2.20920700
17MP0009046_muscle_twitch2.17459061
18MP0002572_abnormal_emotion/affect_behav2.17281901
19MP0002064_seizures2.16180941
20MP0003787_abnormal_imprinting2.13414315
21MP0003122_maternal_imprinting2.10468021
22MP0006276_abnormal_autonomic_nervous2.07842166
23MP0001984_abnormal_olfaction2.00086999
24MP0002184_abnormal_innervation1.98628686
25MP0001486_abnormal_startle_reflex1.97672819
26MP0002272_abnormal_nervous_system1.88149875
27MP0002638_abnormal_pupillary_reflex1.86714433
28MP0005394_taste/olfaction_phenotype1.81712156
29MP0005499_abnormal_olfactory_system1.81712156
30MP0001188_hyperpigmentation1.74946286
31MP0001501_abnormal_sleep_pattern1.74249306
32MP0002557_abnormal_social/conspecific_i1.73840095
33MP0006292_abnormal_olfactory_placode1.64364985
34MP0002736_abnormal_nociception_after1.64246665
35MP0002735_abnormal_chemical_nociception1.63719906
36MP0002102_abnormal_ear_morphology1.62637705
37MP0003123_paternal_imprinting1.62119552
38MP0008789_abnormal_olfactory_epithelium1.59862716
39MP0003121_genomic_imprinting1.59463061
40MP0002067_abnormal_sensory_capabilities1.56497387
41MP0006072_abnormal_retinal_apoptosis1.50078230
42MP0002733_abnormal_thermal_nociception1.48176956
43MP0004924_abnormal_behavior1.47686870
44MP0005386_behavior/neurological_phenoty1.47686870
45MP0004858_abnormal_nervous_system1.46467997
46MP0000631_abnormal_neuroendocrine_gland1.44808799
47MP0001970_abnormal_pain_threshold1.44499664
48MP0001905_abnormal_dopamine_level1.43455040
49MP0010386_abnormal_urinary_bladder1.43085332
50MP0001502_abnormal_circadian_rhythm1.42514953
51MP0004811_abnormal_neuron_physiology1.42043950
52MP0003879_abnormal_hair_cell1.38303411
53MP0001293_anophthalmia1.36659174
54MP0000955_abnormal_spinal_cord1.36228538
55MP0002938_white_spotting1.35095638
56MP0002882_abnormal_neuron_morphology1.35016435
57MP0001440_abnormal_grooming_behavior1.32026574
58MP0000566_synostosis1.30529167
59MP0010030_abnormal_orbit_morphology1.29312672
60MP0002751_abnormal_autonomic_nervous1.28084236
61MP0002152_abnormal_brain_morphology1.23018185
62MP0008995_early_reproductive_senescence1.18639353
63MP0002909_abnormal_adrenal_gland1.17017017
64MP0002234_abnormal_pharynx_morphology1.16480076
65MP0008569_lethality_at_weaning1.15099706
66MP0003861_abnormal_nervous_system1.13388634
67MP0002928_abnormal_bile_duct1.11824698
68MP0005551_abnormal_eye_electrophysiolog1.11211646
69MP0008877_abnormal_DNA_methylation1.11102911
70MP0001346_abnormal_lacrimal_gland1.10129333
71MP0004885_abnormal_endolymph1.09586507
72MP0002066_abnormal_motor_capabilities/c1.08498737
73MP0002752_abnormal_somatic_nervous1.06475367
74MP0003283_abnormal_digestive_organ1.06466632
75MP0005171_absent_coat_pigmentation1.05719010
76MP0005391_vision/eye_phenotype1.05078477
77MP0005195_abnormal_posterior_eye1.00659391
78MP0003195_calcinosis0.99778021
79MP0001324_abnormal_eye_pigmentation0.96444768
80MP0000026_abnormal_inner_ear0.96352586
81MP0003937_abnormal_limbs/digits/tail_de0.95532077
82MP0003011_delayed_dark_adaptation0.90601802
83MP0001963_abnormal_hearing_physiology0.89114055
84MP0005174_abnormal_tail_pigmentation0.86987426
85MP0004142_abnormal_muscle_tone0.86807856
86MP0004742_abnormal_vestibular_system0.86163379
87MP0000534_abnormal_ureter_morphology0.86120815
88MP0005253_abnormal_eye_physiology0.85069110
89MP0004233_abnormal_muscle_weight0.84783492
90MP0001286_abnormal_eye_development0.84376942
91MP0003632_abnormal_nervous_system0.83077614
92MP0005248_abnormal_Harderian_gland0.81606774
93MP0002233_abnormal_nose_morphology0.81143877
94MP0003890_abnormal_embryonic-extraembry0.79620060
95MP0003942_abnormal_urinary_system0.79218412
96MP0001177_atelectasis0.79214111
97MP0002282_abnormal_trachea_morphology0.78935023
98MP0002229_neurodegeneration0.78818048
99MP0004145_abnormal_muscle_electrophysio0.78698708
100MP0000569_abnormal_digit_pigmentation0.77962588
101MP0002837_dystrophic_cardiac_calcinosis0.76354265
102MP0002697_abnormal_eye_size0.75417286
103MP0002249_abnormal_larynx_morphology0.75257103
104MP0000049_abnormal_middle_ear0.75019129
105MP0004133_heterotaxia0.74147743
106MP0002069_abnormal_eating/drinking_beha0.72273749
107MP0001485_abnormal_pinna_reflex0.72096282
108MP0001299_abnormal_eye_distance/0.71182718
109MP0003755_abnormal_palate_morphology0.70500453
110MP0008961_abnormal_basal_metabolism0.70047720
111MP0002116_abnormal_craniofacial_bone0.69879796
112MP0002090_abnormal_vision0.69269085
113MP0002163_abnormal_gland_morphology0.69235632
114MP0003938_abnormal_ear_development0.67754226
115MP0000537_abnormal_urethra_morphology0.64985427
116MP0003119_abnormal_digestive_system0.64846212
117MP0008872_abnormal_physiological_respon0.64789124
118MP0005187_abnormal_penis_morphology0.64036108
119MP0009780_abnormal_chondrocyte_physiolo0.62572678
120MP0003631_nervous_system_phenotype0.61047585

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.92883767
2Myokymia (HP:0002411)4.38373720
3Oligodactyly (hands) (HP:0001180)3.69314955
4Focal seizures (HP:0007359)3.53505902
5Epileptic encephalopathy (HP:0200134)3.46349996
6Febrile seizures (HP:0002373)3.38981869
7Intestinal atresia (HP:0011100)3.00710526
8Abnormality of the labia minora (HP:0012880)2.99678507
9Pancreatic cysts (HP:0001737)2.96169970
10Progressive cerebellar ataxia (HP:0002073)2.91938127
11Visual hallucinations (HP:0002367)2.91598410
12Absence seizures (HP:0002121)2.91145792
13Limb dystonia (HP:0002451)2.76899126
14Chronic hepatic failure (HP:0100626)2.62361958
15Ankle clonus (HP:0011448)2.59035693
16Generalized tonic-clonic seizures (HP:0002069)2.57614952
17Oligodactyly (HP:0012165)2.57429311
18Optic nerve hypoplasia (HP:0000609)2.49137917
19Amblyopia (HP:0000646)2.48445540
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47727064
21Aplasia/Hypoplasia of the tibia (HP:0005772)2.46870059
22Dialeptic seizures (HP:0011146)2.43433437
23Gait imbalance (HP:0002141)2.40191772
24Hypoplastic pelvis (HP:0008839)2.37014331
25Gastrointestinal atresia (HP:0002589)2.36582347
26Abnormality of the renal medulla (HP:0100957)2.36122255
27Anencephaly (HP:0002323)2.33441357
28Tubulointerstitial nephritis (HP:0001970)2.30462310
29Congenital primary aphakia (HP:0007707)2.30336677
30Atonic seizures (HP:0010819)2.29367809
31Abnormality of the ischium (HP:0003174)2.27270584
32Short tibia (HP:0005736)2.24562361
33Cystic liver disease (HP:0006706)2.23074203
34Dynein arm defect of respiratory motile cilia (HP:0012255)2.22888828
35Absent/shortened dynein arms (HP:0200106)2.22888828
36Action tremor (HP:0002345)2.20440579
37Nephrogenic diabetes insipidus (HP:0009806)2.19091856
38Depression (HP:0000716)2.14123992
39Abnormal ciliary motility (HP:0012262)2.13353180
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.13341721
41Esophageal atresia (HP:0002032)2.13232105
42Megalencephaly (HP:0001355)2.12126648
43Specific learning disability (HP:0001328)2.10867287
44Epileptiform EEG discharges (HP:0011182)2.10015355
45EEG with generalized epileptiform discharges (HP:0011198)2.09944469
46Drooling (HP:0002307)2.09696812
47Excessive salivation (HP:0003781)2.09696812
48Broad-based gait (HP:0002136)2.08745850
49Postaxial hand polydactyly (HP:0001162)2.06335210
50Male pseudohermaphroditism (HP:0000037)2.04313577
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04173766
52Genital tract atresia (HP:0001827)2.04053598
53Abnormality of the pubic bones (HP:0003172)2.03737002
54Abnormal respiratory motile cilium morphology (HP:0005938)2.03348769
55Abnormal respiratory epithelium morphology (HP:0012253)2.03348769
56Sclerocornea (HP:0000647)2.03227678
57Papillary thyroid carcinoma (HP:0002895)2.02931498
58Pointed chin (HP:0000307)2.02150441
59Postural instability (HP:0002172)2.01159459
60Molar tooth sign on MRI (HP:0002419)1.98345391
61Abnormality of midbrain morphology (HP:0002418)1.98345391
62Split foot (HP:0001839)1.98189198
63Hypothermia (HP:0002045)1.97522548
64Fetal akinesia sequence (HP:0001989)1.97081432
65Medial flaring of the eyebrow (HP:0010747)1.95281836
66Congenital malformation of the right heart (HP:0011723)1.95055873
67Double outlet right ventricle (HP:0001719)1.95055873
68Type II lissencephaly (HP:0007260)1.94968355
69Supranuclear gaze palsy (HP:0000605)1.94513130
70Vaginal atresia (HP:0000148)1.93816727
71Dysdiadochokinesis (HP:0002075)1.93102036
72Abnormal eating behavior (HP:0100738)1.91562123
73Postaxial foot polydactyly (HP:0001830)1.90862819
74Preaxial foot polydactyly (HP:0001841)1.89946898
75Polyphagia (HP:0002591)1.89047677
76Bifid tongue (HP:0010297)1.88957532
77Midline defect of the nose (HP:0004122)1.88823476
78Shoulder girdle muscle weakness (HP:0003547)1.87837683
79Lissencephaly (HP:0001339)1.86591322
80Abnormal respiratory motile cilium physiology (HP:0012261)1.86285955
81Genetic anticipation (HP:0003743)1.86014239
82Renal hypoplasia (HP:0000089)1.85265664
83Preaxial hand polydactyly (HP:0001177)1.84958353
84Urinary bladder sphincter dysfunction (HP:0002839)1.84503592
85Abnormality of the renal cortex (HP:0011035)1.83480046
86Aplasia/Hypoplasia of the sternum (HP:0006714)1.81561457
87Narrow nasal bridge (HP:0000446)1.81254456
88Impaired vibration sensation in the lower limbs (HP:0002166)1.80509819
89Narrow forehead (HP:0000341)1.80438869
90Abdominal situs inversus (HP:0003363)1.80318688
91Abnormality of abdominal situs (HP:0011620)1.80318688
92Nephronophthisis (HP:0000090)1.80022256
93Gaze-evoked nystagmus (HP:0000640)1.80011434
94Retinal dysplasia (HP:0007973)1.79896226
95Truncal ataxia (HP:0002078)1.79243709
96Ankyloglossia (HP:0010296)1.78453840
97Labial hypoplasia (HP:0000066)1.78446229
98Anterior segment dysgenesis (HP:0007700)1.76331385
99Impaired smooth pursuit (HP:0007772)1.75475726
100Congenital stationary night blindness (HP:0007642)1.74142953
101Short foot (HP:0001773)1.73203388
102Torticollis (HP:0000473)1.72808560
103True hermaphroditism (HP:0010459)1.72296617
104Absent septum pellucidum (HP:0001331)1.72235641
105Hypsarrhythmia (HP:0002521)1.72225575
106Absent speech (HP:0001344)1.71827749
107Anxiety (HP:0000739)1.71352416
108Pancreatic fibrosis (HP:0100732)1.70996876
109Elfin facies (HP:0004428)1.70616135
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70308359
111High anterior hairline (HP:0009890)1.69157099
112Septo-optic dysplasia (HP:0100842)1.68063387
113Cerebellar dysplasia (HP:0007033)1.67915400
114Occipital encephalocele (HP:0002085)1.67840237
115Abnormality of the corticospinal tract (HP:0002492)1.67823864
116Micropenis (HP:0000054)1.67531410
117Gonadal dysgenesis (HP:0000133)1.67317816
118Maternal diabetes (HP:0009800)1.66041711
119Hemiparesis (HP:0001269)1.65981429
120Hypoplastic iliac wings (HP:0002866)1.65712164
121Renal duplication (HP:0000075)1.65410478
122Tubulointerstitial abnormality (HP:0001969)1.64351460
123Cutaneous finger syndactyly (HP:0010554)1.64060357
124Abnormality of the aortic arch (HP:0012303)1.63468024
125Poor eye contact (HP:0000817)1.62429919
126Vitreoretinal degeneration (HP:0000655)1.62417181
127Anosmia (HP:0000458)1.62192027
128Poor coordination (HP:0002370)1.61832782
129Gonadotropin excess (HP:0000837)1.61559321
130Failure to thrive in infancy (HP:0001531)1.61380013
131Hypoventilation (HP:0002791)1.60312843
132Growth hormone deficiency (HP:0000824)1.60172835
133Insomnia (HP:0100785)1.59625058
134Bradykinesia (HP:0002067)1.58771877
135Obsessive-compulsive behavior (HP:0000722)1.58238529
136Hepatoblastoma (HP:0002884)1.58057858
137Aplasia/Hypoplasia of the lens (HP:0008063)1.57536094
138Abnormality of ocular smooth pursuit (HP:0000617)1.57531885
139Abnormality of the lower motor neuron (HP:0002366)1.56939751
140Progressive inability to walk (HP:0002505)1.56872700
141Morphological abnormality of the middle ear (HP:0008609)1.56178446
142Hyperventilation (HP:0002883)1.55928291
143Aqueductal stenosis (HP:0002410)1.55904330
144Exotropia (HP:0000577)1.55643324
145Anophthalmia (HP:0000528)1.55462079
146Cutaneous syndactyly (HP:0012725)1.55143598
147Aplasia involving bones of the upper limbs (HP:0009823)1.54886476
148Aplasia of the phalanges of the hand (HP:0009802)1.54886476
149Aplasia involving bones of the extremities (HP:0009825)1.54886476
150Incomplete penetrance (HP:0003829)1.54689378
151Truncus arteriosus (HP:0001660)1.53031926
152Hypoplasia of the brainstem (HP:0002365)1.52833046
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.52833046
154Mutism (HP:0002300)1.52682295
155Urinary urgency (HP:0000012)1.52504172
156Autism (HP:0000717)1.52186465
157Rib fusion (HP:0000902)1.51868962
158Scrotal hypoplasia (HP:0000046)1.51721955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.87980305
2MARK13.55837864
3MAP3K93.47593784
4EPHA43.17729385
5MAP3K43.11222881
6FRK3.01279067
7NTRK22.94821874
8KSR12.64966854
9MINK12.53080618
10PRKD32.31026368
11MAP2K72.31008804
12BMPR1B2.28684071
13PAK62.00512546
14SIK31.98720099
15MAPK131.97830003
16PRPF4B1.96432431
17MAPK151.79617894
18MAP3K121.76058919
19TRIM281.67929647
20LATS21.65572062
21KSR21.62679343
22CASK1.52369727
23TYRO31.48929471
24LMTK21.43848051
25NEK11.40319805
26PNCK1.35648604
27BCR1.33118787
28STK391.32649097
29ACVR1B1.27659172
30MAP2K41.25561557
31INSRR1.23318493
32SGK21.22807300
33STK381.22166412
34SGK2231.21038752
35SGK4941.21038752
36DAPK21.17140361
37MKNK21.16742349
38PLK21.16727623
39MAP4K21.16421705
40PKN11.11397468
41ERBB31.09552018
42FGFR21.09231178
43SIK21.08248089
44TGFBR11.07938198
45CDK51.05176023
46UHMK11.04335516
47STK241.04005817
48WNK41.03153078
49PAK31.00838156
50STK38L1.00812605
51VRK11.00579396
52MKNK10.99933680
53PHKG20.99345800
54PHKG10.99345800
55DYRK1A0.96500205
56DYRK20.96460114
57BRD40.95618422
58ADRBK20.95391916
59DAPK10.94903374
60CAMKK10.93120414
61NLK0.92996788
62LATS10.92976898
63TAOK10.91248317
64BRSK10.86809600
65PRKCE0.84777181
66GRK50.84153391
67CSNK1G20.84093338
68PRKCG0.83017201
69TIE10.82526360
70CDK180.82238727
71PLK30.81738732
72WNK30.81697926
73WEE10.81130069
74NUAK10.78942920
75SGK30.77835180
76EPHB20.75997038
77CAMK2A0.74841729
78EPHA30.74751155
79NTRK10.74661757
80PINK10.74459275
81DYRK30.74198368
82SRPK10.72285174
83CDK140.71765026
84CAMK1G0.71683095
85CDK150.70721012
86BMPR20.65223178
87TNIK0.64572088
88AKT30.63963675
89RET0.63586056
90CSNK1G30.61908538
91MAP3K60.61447237
92STK30.60892151
93CDK11A0.60821286
94BRAF0.58382943
95CDK30.56914355
96CSNK1A1L0.56867887
97FER0.56489462
98MARK20.56481805
99MAP3K130.55908710
100NEK60.54860312
101GRK10.54473851
102OXSR10.54318367
103PLK40.53473841
104CAMK10.53395250
105STK110.53203372
106CDC42BPA0.52498378
107ALK0.52245279
108SGK10.52220483
109IRAK20.51217441
110ARAF0.50545027
111OBSCN0.49864564
112MAPK100.49780353
113YES10.49470322
114CSNK1G10.49097722
115TAOK20.49092906
116PRKG10.48726094
117ZAK0.48693117
118CSNK1D0.48684597
119CDK190.48353352
120STK160.48023455
121PRKCZ0.47830605
122RAF10.44195101
123WNK10.43386304
124CAMK40.43346995
125CDK80.42869854
126PRKACA0.42639809
127TNK20.40417038
128CDC70.40211237
129IRAK10.38778906
130CSNK1A10.38043622
131ERBB20.37984242
132CAMK1D0.37784423
133PRKCH0.37693912
134CDK120.37251682
135CAMK2B0.37201196
136RPS6KA30.36739527
137ADRBK10.36609655
138CSNK1E0.36349988
139PRKACB0.34952573
140PRKAA10.34450244
141RPS6KB10.34189703
142FGFR10.31657992

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57825661
2Synaptic vesicle cycle_Homo sapiens_hsa047213.15247507
3Olfactory transduction_Homo sapiens_hsa047402.76065154
4GABAergic synapse_Homo sapiens_hsa047272.64259267
5Circadian entrainment_Homo sapiens_hsa047132.54558340
6Morphine addiction_Homo sapiens_hsa050322.43046269
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39273032
8Glutamatergic synapse_Homo sapiens_hsa047242.30729315
9Amphetamine addiction_Homo sapiens_hsa050312.29417763
10Dopaminergic synapse_Homo sapiens_hsa047282.19553205
11Cocaine addiction_Homo sapiens_hsa050302.09872549
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08275042
13Insulin secretion_Homo sapiens_hsa049112.06588230
14Butanoate metabolism_Homo sapiens_hsa006502.00234347
15Cholinergic synapse_Homo sapiens_hsa047251.96796348
16Long-term potentiation_Homo sapiens_hsa047201.96735997
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.87776372
18Serotonergic synapse_Homo sapiens_hsa047261.82708253
19Taste transduction_Homo sapiens_hsa047421.79759239
20Salivary secretion_Homo sapiens_hsa049701.70008653
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65083620
22Renin secretion_Homo sapiens_hsa049241.56693875
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50606033
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50514988
25Oxytocin signaling pathway_Homo sapiens_hsa049211.49906164
26GnRH signaling pathway_Homo sapiens_hsa049121.49091042
27Circadian rhythm_Homo sapiens_hsa047101.48763907
28Gap junction_Homo sapiens_hsa045401.46761451
29Long-term depression_Homo sapiens_hsa047301.45764455
30Gastric acid secretion_Homo sapiens_hsa049711.41685985
31Steroid biosynthesis_Homo sapiens_hsa001001.38847166
32Oocyte meiosis_Homo sapiens_hsa041141.38623923
33Axon guidance_Homo sapiens_hsa043601.37910967
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37569062
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33171768
36Calcium signaling pathway_Homo sapiens_hsa040201.31469714
37Melanogenesis_Homo sapiens_hsa049161.30512738
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26247899
39Propanoate metabolism_Homo sapiens_hsa006401.25711425
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22223786
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18710944
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18561640
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18541852
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.18515678
45ErbB signaling pathway_Homo sapiens_hsa040121.15598231
46Linoleic acid metabolism_Homo sapiens_hsa005911.15467644
47Hedgehog signaling pathway_Homo sapiens_hsa043401.12943052
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11360410
49cAMP signaling pathway_Homo sapiens_hsa040241.10961765
50Estrogen signaling pathway_Homo sapiens_hsa049151.10424899
51Collecting duct acid secretion_Homo sapiens_hsa049661.07692199
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.05625400
53Nitrogen metabolism_Homo sapiens_hsa009101.05053540
54Wnt signaling pathway_Homo sapiens_hsa043101.04738402
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03523539
56Glioma_Homo sapiens_hsa052141.02778839
57Basal cell carcinoma_Homo sapiens_hsa052171.01628728
58Phototransduction_Homo sapiens_hsa047441.01308876
59Hippo signaling pathway_Homo sapiens_hsa043901.00475636
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97398237
61Type II diabetes mellitus_Homo sapiens_hsa049300.96628895
62Alcoholism_Homo sapiens_hsa050340.95697946
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95568827
64Colorectal cancer_Homo sapiens_hsa052100.95420871
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94288275
66beta-Alanine metabolism_Homo sapiens_hsa004100.93189971
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92414658
68Dorso-ventral axis formation_Homo sapiens_hsa043200.92186206
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91924209
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91756947
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88959343
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.87384619
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87129690
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86334161
75Endometrial cancer_Homo sapiens_hsa052130.85440696
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85106164
77Choline metabolism in cancer_Homo sapiens_hsa052310.84258794
78mRNA surveillance pathway_Homo sapiens_hsa030150.81008479
79MAPK signaling pathway_Homo sapiens_hsa040100.80908553
80Ether lipid metabolism_Homo sapiens_hsa005650.80562424
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79163985
82Tryptophan metabolism_Homo sapiens_hsa003800.79150781
83ABC transporters_Homo sapiens_hsa020100.77637037
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.76681415
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76616849
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.76555628
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76530424
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.72676678
89Notch signaling pathway_Homo sapiens_hsa043300.71894703
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70733421
91Vibrio cholerae infection_Homo sapiens_hsa051100.70334051
92Caffeine metabolism_Homo sapiens_hsa002320.69753034
93mTOR signaling pathway_Homo sapiens_hsa041500.67444066
94Dilated cardiomyopathy_Homo sapiens_hsa054140.66798971
95Protein export_Homo sapiens_hsa030600.65766947
96Peroxisome_Homo sapiens_hsa041460.65630555
97Non-small cell lung cancer_Homo sapiens_hsa052230.65266688
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62231363
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62106963
100Cell cycle_Homo sapiens_hsa041100.61765299
101Ras signaling pathway_Homo sapiens_hsa040140.60998695
102Bile secretion_Homo sapiens_hsa049760.59853472
103Oxidative phosphorylation_Homo sapiens_hsa001900.59798271
104Ovarian steroidogenesis_Homo sapiens_hsa049130.59368093
105Glucagon signaling pathway_Homo sapiens_hsa049220.59125621
106Chemical carcinogenesis_Homo sapiens_hsa052040.58410513
107Retinol metabolism_Homo sapiens_hsa008300.58177152
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57677654
109Rap1 signaling pathway_Homo sapiens_hsa040150.57253492
110Renal cell carcinoma_Homo sapiens_hsa052110.56091845
111Histidine metabolism_Homo sapiens_hsa003400.54842714
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54011579
113Arginine and proline metabolism_Homo sapiens_hsa003300.52097810
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51125558
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50983032
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50974937
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50499195
118Thyroid hormone synthesis_Homo sapiens_hsa049180.50331280
119Cardiac muscle contraction_Homo sapiens_hsa042600.49643930
120Huntingtons disease_Homo sapiens_hsa050160.49187311
121RNA degradation_Homo sapiens_hsa030180.48786847
122Fatty acid biosynthesis_Homo sapiens_hsa000610.47338437
123Fatty acid metabolism_Homo sapiens_hsa012120.46251770
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45601587
125Parkinsons disease_Homo sapiens_hsa050120.44496178
126Inositol phosphate metabolism_Homo sapiens_hsa005620.44364435
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43733334
128Insulin signaling pathway_Homo sapiens_hsa049100.43184526
129TGF-beta signaling pathway_Homo sapiens_hsa043500.40031472
130Pancreatic secretion_Homo sapiens_hsa049720.39973835
131Prion diseases_Homo sapiens_hsa050200.39898860
132Melanoma_Homo sapiens_hsa052180.39129236
133Prolactin signaling pathway_Homo sapiens_hsa049170.37817873
134Regulation of autophagy_Homo sapiens_hsa041400.37694930
135Fanconi anemia pathway_Homo sapiens_hsa034600.36984832
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36157667
137Tight junction_Homo sapiens_hsa045300.35637377
138VEGF signaling pathway_Homo sapiens_hsa043700.34947544
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34870015
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.34083666
141Basal transcription factors_Homo sapiens_hsa030220.33777168
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33628338
143MicroRNAs in cancer_Homo sapiens_hsa052060.33338023

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