ANKRD30BL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.90556203
2negative regulation of cell cycle G2/M phase transition (GO:1902750)4.86376828
3positive regulation of developmental pigmentation (GO:0048087)4.83688963
4cellular response to ethanol (GO:0071361)4.74894038
5regulation of pigment cell differentiation (GO:0050932)4.71885063
6positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.69448000
7monoubiquitinated protein deubiquitination (GO:0035520)4.59930276
8regulation of hippo signaling (GO:0035330)4.43735983
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.40594781
10ear development (GO:0043583)4.27936362
11cytoplasmic mRNA processing body assembly (GO:0033962)4.27911805
12nuclear pore complex assembly (GO:0051292)4.25583632
13snRNA transcription (GO:0009301)4.02739013
14glucocorticoid receptor signaling pathway (GO:0042921)3.97933863
15nuclear pore organization (GO:0006999)3.85737252
16histone H3-K4 methylation (GO:0051568)3.80936183
17lymph vessel development (GO:0001945)3.76216955
18interkinetic nuclear migration (GO:0022027)3.69311725
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.63826017
20ovulation from ovarian follicle (GO:0001542)3.63003701
21peptidyl-lysine methylation (GO:0018022)3.58008624
22peptidyl-lysine trimethylation (GO:0018023)3.55174780
23T cell lineage commitment (GO:0002360)3.50811397
24dorsal/ventral axis specification (GO:0009950)3.50398140
25histone lysine methylation (GO:0034968)3.48926924
26corticosteroid receptor signaling pathway (GO:0031958)3.44479500
27oocyte development (GO:0048599)3.35681554
28adherens junction assembly (GO:0034333)3.34486025
29spleen development (GO:0048536)3.33597535
30regulation of developmental pigmentation (GO:0048070)3.28321532
31protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)3.26664635
32pre-miRNA processing (GO:0031054)3.23593140
33negative regulation of fatty acid transport (GO:2000192)3.21651456
34negative regulation of histone methylation (GO:0031061)3.19627199
35negative regulation of osteoblast proliferation (GO:0033689)3.12724738
36TOR signaling (GO:0031929)3.11881094
37regulation of gene silencing by RNA (GO:0060966)3.10750843
38regulation of posttranscriptional gene silencing (GO:0060147)3.10750843
39regulation of gene silencing by miRNA (GO:0060964)3.10750843
40dosage compensation (GO:0007549)3.10682442
41pericardium development (GO:0060039)3.08966652
42regulation of fatty acid beta-oxidation (GO:0031998)3.08767880
43pore complex assembly (GO:0046931)3.08249678
44cell-substrate adherens junction assembly (GO:0007045)3.07492220
45focal adhesion assembly (GO:0048041)3.07492220
46peptidyl-lysine dimethylation (GO:0018027)3.05954585
47negative regulation of calcium ion transport into cytosol (GO:0010523)3.02408914
48lipid translocation (GO:0034204)3.02360382
49phospholipid translocation (GO:0045332)3.02360382
50negative regulation of DNA repair (GO:0045738)3.01475821
51regulation of histone H3-K4 methylation (GO:0051569)3.01250089
52mitotic sister chromatid cohesion (GO:0007064)3.00405956
53negative regulation of myotube differentiation (GO:0010832)2.98100440
54cellular response to exogenous dsRNA (GO:0071360)2.97108372
55regulation of NFAT protein import into nucleus (GO:0051532)2.96908807
56SMAD protein complex assembly (GO:0007183)2.93852449
57melanin metabolic process (GO:0006582)2.92355548
58histone H4-K8 acetylation (GO:0043982)2.92157351
59histone H4-K5 acetylation (GO:0043981)2.92157351
60histone H4-K16 acetylation (GO:0043984)2.91132558
61cell-substrate junction assembly (GO:0007044)2.90679022
62negative regulation of sodium ion transport (GO:0010766)2.85174412
63regulation of establishment of cell polarity (GO:2000114)2.84359537
64cranial nerve morphogenesis (GO:0021602)2.83532459
65mammary gland epithelial cell differentiation (GO:0060644)2.82405399
66striated muscle atrophy (GO:0014891)2.82199469
67DNA duplex unwinding (GO:0032508)2.81145187
68UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80400153
69regulation of chromatin binding (GO:0035561)2.78311588
70mesenchymal cell development (GO:0014031)2.77927251
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.76860708
72protein K48-linked deubiquitination (GO:0071108)2.75906712
73hemidesmosome assembly (GO:0031581)2.75786160
74DNA geometric change (GO:0032392)2.74798175
75histone H3-K36 demethylation (GO:0070544)2.67243716
76histone methylation (GO:0016571)2.66258280
77somitogenesis (GO:0001756)2.66217449
78negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.61968641
79histone H3-K9 methylation (GO:0051567)2.61828907
80DNA synthesis involved in DNA repair (GO:0000731)2.61287324
81positive regulation of DNA-templated transcription, initiation (GO:2000144)2.56826391
82regulation of mammary gland epithelial cell proliferation (GO:0033599)2.55898903
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55108807
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.55108807
85regulation of translation, ncRNA-mediated (GO:0045974)2.55108807
86peptidyl-threonine phosphorylation (GO:0018107)2.54885386
87myelination in peripheral nervous system (GO:0022011)2.54477769
88peripheral nervous system axon ensheathment (GO:0032292)2.54477769
89negative regulation of keratinocyte proliferation (GO:0010839)2.52801582
90segmentation (GO:0035282)2.51929029
91morphogenesis of an epithelial sheet (GO:0002011)2.49026370
92peripheral nervous system neuron development (GO:0048935)2.48510289
93histone demethylation (GO:0016577)2.48088908
94positive regulation of myotube differentiation (GO:0010831)2.45839808
95neural tube development (GO:0021915)2.45822952
96regulation of DNA damage checkpoint (GO:2000001)2.44972044
97regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.44606904
98nucleus localization (GO:0051647)2.44030155
99regulation of MHC class I biosynthetic process (GO:0045343)2.43958570
100negative regulation of viral release from host cell (GO:1902187)2.43406841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.73412086
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.44137781
3E2F7_22180533_ChIP-Seq_HELA_Human4.13845914
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.89983378
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.54677754
6TP53_16413492_ChIP-PET_HCT116_Human2.47222143
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.44271632
8AHR_22903824_ChIP-Seq_MCF-7_Human2.34678644
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.30134462
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29584026
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.22894703
12FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human2.22103727
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.21396431
14CTNNB1_20460455_ChIP-Seq_HCT116_Human2.20587214
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16247722
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15599941
17PKCTHETA_26484144_Chip-Seq_BREAST_Human2.14685146
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.11393282
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.07077899
20CDX2_20551321_ChIP-Seq_CACO-2_Human2.05985377
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04873997
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.02290616
23* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.00557416
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.94740953
25MYC_22102868_ChIP-Seq_BL_Human1.92139854
26SOX9_24532713_ChIP-Seq_HFSC_Mouse1.90605249
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89110786
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85895056
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82005596
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.76364001
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72934794
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.72544952
33SCL_19346495_ChIP-Seq_HPC-7_Human1.72173490
34GATA1_22025678_ChIP-Seq_K562_Human1.68250172
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66578986
36AR_21572438_ChIP-Seq_LNCaP_Human1.65832819
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62121939
38TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.57116861
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53504183
40STAT3_23295773_ChIP-Seq_U87_Human1.53347914
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52935481
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.52817917
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51978423
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50478624
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.49734799
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49121486
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46220297
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46220297
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.45945813
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.43928904
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40977470
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33473959
53RXR_22108803_ChIP-Seq_LS180_Human1.32180312
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30544645
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26843794
56CIITA_25753668_ChIP-Seq_RAJI_Human1.24895092
57* BRD4_25478319_ChIP-Seq_HGPS_Human1.23636043
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22454000
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.20661975
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.19147645
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.18452741
62VDR_21846776_ChIP-Seq_THP-1_Human1.18441583
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18389672
64AR_19668381_ChIP-Seq_PC3_Human1.17972418
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.17296260
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.15196146
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.15092083
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14935083
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14427016
70GBX2_23144817_ChIP-Seq_PC3_Human1.13337711
71TCF7_22412390_ChIP-Seq_EML_Mouse1.12199335
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.12179210
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07744804
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06970659
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05072977
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05072977
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.02338235
78YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99878465
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99266489
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98466433
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97909301
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97211022
83TP53_22127205_ChIP-Seq_IMR90_Human0.94118992
84TCF4_23295773_ChIP-Seq_U87_Human0.93719406
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92737357
86MITF_21258399_ChIP-Seq_MELANOMA_Human0.92421858
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91458827
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91446413
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.90960990
90UBF1/2_26484160_Chip-Seq_HMECs_Human0.90816389
91RING1B_27294783_Chip-Seq_NPCs_Mouse0.90767255
92SMAD4_21799915_ChIP-Seq_A2780_Human0.89859146
93EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89504845
94RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89504845
95WDR5_24793694_ChIP-Seq_LNCAP_Human0.89358620
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88978621
97SMAD3_21741376_ChIP-Seq_HESCs_Human0.88673228
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.88605865
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.88078984
100TP53_23651856_ChIP-Seq_MEFs_Mouse0.87940626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.94338777
2MP0005076_abnormal_cell_differentiation3.73799740
3MP0005623_abnormal_meninges_morphology3.67276941
4MP0000569_abnormal_digit_pigmentation3.29345108
5MP0003045_fibrosis3.22738446
6MP0003705_abnormal_hypodermis_morpholog2.87015900
7MP0000537_abnormal_urethra_morphology2.86832404
8MP0000383_abnormal_hair_follicle2.79808689
9MP0001346_abnormal_lacrimal_gland2.64740219
10MP0002249_abnormal_larynx_morphology2.62126480
11MP0002009_preneoplasia2.48096816
12MP0004381_abnormal_hair_follicle2.20192445
13MP0008961_abnormal_basal_metabolism2.19503607
14MP0002168_other_aberrant_phenotype2.06449446
15MP0010678_abnormal_skin_adnexa1.97360637
16MP0000372_irregular_coat_pigmentation1.92660162
17MP0000371_diluted_coat_color1.87741796
18MP0010352_gastrointestinal_tract_polyps1.86372939
19MP0010307_abnormal_tumor_latency1.85212972
20MP0004233_abnormal_muscle_weight1.82855665
21MP0003091_abnormal_cell_migration1.82793612
22MP0010094_abnormal_chromosome_stability1.80589710
23MP0000516_abnormal_urinary_system1.77971043
24MP0005367_renal/urinary_system_phenotyp1.77971043
25MP0002108_abnormal_muscle_morphology1.77186125
26MP0000733_abnormal_muscle_development1.76939923
27MP0003763_abnormal_thymus_physiology1.72322901
28MP0003890_abnormal_embryonic-extraembry1.60503862
29MP0004272_abnormal_basement_membrane1.60233008
30MP0000003_abnormal_adipose_tissue1.57882261
31MP0005310_abnormal_salivary_gland1.57113383
32MP0001915_intracranial_hemorrhage1.46366409
33MP0002332_abnormal_exercise_endurance1.42743805
34MP0004808_abnormal_hematopoietic_stem1.41957878
35MP0003942_abnormal_urinary_system1.41332543
36MP0003077_abnormal_cell_cycle1.37385859
37MP0003111_abnormal_nucleus_morphology1.37273655
38MP0001661_extended_life_span1.32723337
39MP0005408_hypopigmentation1.30896012
40MP0003950_abnormal_plasma_membrane1.27372861
41MP0002075_abnormal_coat/hair_pigmentati1.26695266
42MP0005409_darkened_coat_color1.25916922
43MP0004130_abnormal_muscle_cell1.24837598
44MP0005275_abnormal_skin_tensile1.24529946
45MP0001270_distended_abdomen1.22251297
46MP0003646_muscle_fatigue1.20530012
47MP0002697_abnormal_eye_size1.16927865
48MP0003984_embryonic_growth_retardation1.13802956
49MP0005171_absent_coat_pigmentation1.10594277
50MP0000534_abnormal_ureter_morphology1.10568588
51MP0000681_abnormal_thyroid_gland1.08998178
52MP0009115_abnormal_fat_cell1.07666922
53MP0002088_abnormal_embryonic_growth/wei1.06489685
54MP0000015_abnormal_ear_pigmentation1.05178382
55MP0005395_other_phenotype1.03798996
56MP0005503_abnormal_tendon_morphology1.03560300
57MP0002928_abnormal_bile_duct1.03359866
58MP0002092_abnormal_eye_morphology1.02847236
59MP0000538_abnormal_urinary_bladder1.02407007
60MP0005621_abnormal_cell_physiology0.99153723
61MP0004145_abnormal_muscle_electrophysio0.98722849
62MP0002925_abnormal_cardiovascular_devel0.98467186
63MP0000432_abnormal_head_morphology0.96800079
64MP0001879_abnormal_lymphatic_vessel0.95728081
65MP0008438_abnormal_cutaneous_collagen0.95484275
66MP0000428_abnormal_craniofacial_morphol0.94985609
67MP0002084_abnormal_developmental_patter0.94354701
68MP0005075_abnormal_melanosome_morpholog0.91584244
69MP0000427_abnormal_hair_cycle0.91078921
70MP0000759_abnormal_skeletal_muscle0.90834727
71MP0003786_premature_aging0.90352935
72MP0002086_abnormal_extraembryonic_tissu0.89855093
73MP0005380_embryogenesis_phenotype0.87752054
74MP0001672_abnormal_embryogenesis/_devel0.87752054
75MP0003115_abnormal_respiratory_system0.87413577
76MP0002177_abnormal_outer_ear0.86967716
77MP0005187_abnormal_penis_morphology0.86663547
78MP0003632_abnormal_nervous_system0.86529050
79MP0003937_abnormal_limbs/digits/tail_de0.86325232
80MP0005174_abnormal_tail_pigmentation0.85133223
81MP0000350_abnormal_cell_proliferation0.83516600
82MP0003943_abnormal_hepatobiliary_system0.83050816
83MP0002396_abnormal_hematopoietic_system0.82955050
84MP0002160_abnormal_reproductive_system0.82875472
85MP0004134_abnormal_chest_morphology0.82697988
86MP0003935_abnormal_craniofacial_develop0.82633626
87MP0005023_abnormal_wound_healing0.82233254
88MP0003453_abnormal_keratinocyte_physiol0.77972096
89MP0002970_abnormal_white_adipose0.77163068
90MP0005167_abnormal_blood-brain_barrier0.76346300
91MP0005375_adipose_tissue_phenotype0.75023949
92MP0003315_abnormal_perineum_morphology0.74791560
93MP0010368_abnormal_lymphatic_system0.73804164
94MP0003566_abnormal_cell_adhesion0.73068369
95MP0001186_pigmentation_phenotype0.72955044
96MP0008007_abnormal_cellular_replicative0.71540547
97MP0001299_abnormal_eye_distance/0.71426506
98MP0002114_abnormal_axial_skeleton0.69317037
99MP0003828_pulmonary_edema0.69072098
100MP0004185_abnormal_adipocyte_glucose0.68023931

Predicted human phenotypes

RankGene SetZ-score
1Submucous cleft hard palate (HP:0000176)5.74683713
2Abnormality of the fingertips (HP:0001211)5.22847198
3Septate vagina (HP:0001153)3.74841764
4Persistence of primary teeth (HP:0006335)3.61571945
5Dysmetric saccades (HP:0000641)3.60016058
6Chin dimple (HP:0010751)3.40481706
7Neonatal hypoglycemia (HP:0001998)3.37280935
8Short chin (HP:0000331)3.24098161
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.17307484
10Narrow palate (HP:0000189)3.13899581
11Colitis (HP:0002583)3.11054758
12Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.93269922
13Genetic anticipation (HP:0003743)2.89961364
14Sandal gap (HP:0001852)2.79754683
15Overlapping toe (HP:0001845)2.79476118
16Down-sloping shoulders (HP:0200021)2.79334933
17Thoracolumbar scoliosis (HP:0002944)2.77880975
18Abnormality of the nasal septum (HP:0000419)2.73091304
19Increased neuronal autofluorescent lipopigment (HP:0002074)2.72832342
20Broad face (HP:0000283)2.65236460
21Camptodactyly of toe (HP:0001836)2.58417557
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57308661
23Abnormal number of incisors (HP:0011064)2.55291742
24Long eyelashes (HP:0000527)2.54988262
25Chromsome breakage (HP:0040012)2.52780824
26Midline defect of the nose (HP:0004122)2.51761221
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.51001871
28Heterotopia (HP:0002282)2.45555388
29Overgrowth (HP:0001548)2.45095004
30Cutaneous finger syndactyly (HP:0010554)2.43980325
31Prominent nose (HP:0000448)2.43819225
32Distal arthrogryposis (HP:0005684)2.43551488
33Mitral valve prolapse (HP:0001634)2.42588661
34Lip pit (HP:0100267)2.40372827
35IgA deficiency (HP:0002720)2.38276669
36Hyperventilation (HP:0002883)2.35213621
37Clumsiness (HP:0002312)2.32075481
38Abnormality of the epiphyses of the hand (HP:0005924)2.31456288
39Urethral obstruction (HP:0000796)2.31052650
40Limited hip movement (HP:0008800)2.29825290
41Dislocated radial head (HP:0003083)2.28762683
42Clubbing of toes (HP:0100760)2.28533648
43Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.24541795
44Natal tooth (HP:0000695)2.23969452
45Hypoplasia of the iris (HP:0007676)2.23777676
46Cubitus valgus (HP:0002967)2.18874930
47Increased cerebral lipofuscin (HP:0011813)2.17967869
48Thick eyebrow (HP:0000574)2.15836813
49Flexion contracture of toe (HP:0005830)2.12413784
50Joint contractures involving the joints of the feet (HP:0100492)2.12413784
51Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.10283248
52Abnormality of the radial head (HP:0003995)2.09628113
53Cutaneous syndactyly (HP:0012725)2.05577438
54Protruding tongue (HP:0010808)2.04814887
55Osteolytic defects of the hand bones (HP:0009699)2.03697683
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.03697683
57Synostosis of carpal bones (HP:0005048)2.03577688
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.02636998
59Abnormality of the incisor (HP:0000676)2.01974832
60Wide anterior fontanel (HP:0000260)2.01665308
61Truncal obesity (HP:0001956)1.99679607
62Gaze-evoked nystagmus (HP:0000640)1.99468538
63Abnormal pancreas size (HP:0012094)1.90509932
64Oligodontia (HP:0000677)1.89182209
65Macroorchidism (HP:0000053)1.89026535
66Tented upper lip vermilion (HP:0010804)1.88239968
67Hypopigmentation of the fundus (HP:0007894)1.88095564
68Abnormality of the columella (HP:0009929)1.88012687
69Long foot (HP:0001833)1.87948388
70Spondylolisthesis (HP:0003302)1.87098416
71Advanced eruption of teeth (HP:0006288)1.86186588
72Ulnar bowing (HP:0003031)1.80697632
73Cerebral aneurysm (HP:0004944)1.79273209
742-3 toe syndactyly (HP:0004691)1.78320908
75Bicuspid aortic valve (HP:0001647)1.77006893
76Hypospadias (HP:0000047)1.75600954
77Morphological abnormality of the middle ear (HP:0008609)1.74678893
78Ureteral stenosis (HP:0000071)1.74525106
79Intestinal fistula (HP:0100819)1.73975374
80Ureteral obstruction (HP:0006000)1.72390676
81Laryngomalacia (HP:0001601)1.71452034
82Abnormality of the phalanges of the hallux (HP:0010057)1.70899848
83Homocystinuria (HP:0002156)1.69818761
84Abnormality of homocysteine metabolism (HP:0010919)1.69818761
85Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69115898
86Short 1st metacarpal (HP:0010034)1.69115898
87Low anterior hairline (HP:0000294)1.67735797
88Abnormal glucose tolerance (HP:0001952)1.66798477
89Preaxial foot polydactyly (HP:0001841)1.65298776
90Facial cleft (HP:0002006)1.64700072
91Knee flexion contracture (HP:0006380)1.64541150
92Smooth philtrum (HP:0000319)1.63246658
93Preauricular skin tag (HP:0000384)1.63105793
94Abnormal finger flexion creases (HP:0006143)1.61599865
95Open mouth (HP:0000194)1.61482179
96Widely spaced teeth (HP:0000687)1.60363299
97Bulbous nose (HP:0000414)1.60175052
98Urinary bladder sphincter dysfunction (HP:0002839)1.59344688
99Anal stenosis (HP:0002025)1.58870393
100Acute lymphatic leukemia (HP:0006721)1.58765667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.64348964
2FRK4.63242680
3TRIB33.62535109
4CAMK1G3.37232126
5CAMK1D3.05562045
6ACVR1B2.93886804
7ICK2.93738808
8BRD42.62743741
9MELK2.27291676
10EEF2K2.14562865
11MAPK111.92077734
12TTN1.80141965
13BMPR1B1.78435755
14MKNK21.76338601
15MTOR1.60236499
16TRPM71.49222210
17PKN21.47020915
18AKT31.32166397
19MAPK131.20942206
20MAP3K71.19087604
21ZAK1.18980503
22SGK21.16412156
23BLK1.14847468
24CDC42BPA1.10475600
25PNCK1.09733059
26TLK11.08103748
27PRKAA20.95636057
28MAP3K100.95532781
29LATS10.93579065
30PRKAA10.84748669
31CAMK40.84478294
32PIM10.83910464
33SGK30.83559967
34WNK10.80603319
35OBSCN0.79191133
36MAP3K130.78751861
37FGFR30.78080540
38ATR0.76818295
39SMG10.76792130
40CHEK10.75449310
41CHUK0.75126656
42SGK2230.73108377
43SGK4940.73108377
44MARK20.70998181
45RPS6KA60.67627470
46TEC0.67517134
47FGFR20.66987924
48TGFBR10.66171306
49RPS6KL10.65659383
50RPS6KC10.65659383
51PTK20.65555363
52RPS6KA20.62455619
53CHEK20.62252253
54NLK0.59127926
55PDGFRA0.56542941
56SGK10.55866147
57ATM0.54825256
58PDK10.54335638
59MAPK100.53783233
60CDC70.53283026
61MAP3K60.52507347
62JAK10.52188326
63FGFR10.51995133
64TNIK0.50283906
65RPS6KA50.48748015
66MAP2K30.47266519
67GSK3B0.45895528
68PDGFRB0.45376552
69RPS6KB20.42560180
70PRKDC0.42240612
71AKT10.40879750
72MST1R0.40302277
73NME10.39968804
74MKNK10.39685503
75LMTK20.39392033
76MAPK140.38988195
77MAPK10.38426639
78PDPK10.37735732
79MAPK80.37608008
80CDK20.36981723
81RET0.36453596
82CSNK1A1L0.35616626
83CDK70.33656468
84EPHA40.33557444
85RPS6KA10.32547924
86NEK90.32509380
87TIE10.32339084
88CDK10.32178938
89HCK0.31357632
90CDK40.30821782
91CDK80.29163150
92PBK0.29150213
93RAF10.27015526
94RPS6KB10.26579891
95STK390.25611587
96DDR20.25384205
97CAMK10.25140846
98CDK90.24656208
99MAPK30.20382492
100MAP2K10.20270181

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.23732895
2Lysine degradation_Homo sapiens_hsa003103.23170330
3Type II diabetes mellitus_Homo sapiens_hsa049302.34816796
4Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.17282797
5Alcoholism_Homo sapiens_hsa050341.98398014
6MicroRNAs in cancer_Homo sapiens_hsa052061.91152981
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71937457
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.69624373
9Small cell lung cancer_Homo sapiens_hsa052221.68711889
10Phosphatidylinositol signaling system_Homo sapiens_hsa040701.66837642
11Longevity regulating pathway - mammal_Homo sapiens_hsa042111.56546563
12Homologous recombination_Homo sapiens_hsa034401.49598325
13FoxO signaling pathway_Homo sapiens_hsa040681.47761278
14Fanconi anemia pathway_Homo sapiens_hsa034601.40322149
15Chronic myeloid leukemia_Homo sapiens_hsa052201.38034288
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37726539
17Prostate cancer_Homo sapiens_hsa052151.34402370
18Colorectal cancer_Homo sapiens_hsa052101.32252518
19Non-homologous end-joining_Homo sapiens_hsa034501.28744736
20Viral carcinogenesis_Homo sapiens_hsa052031.26734082
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24920040
22mTOR signaling pathway_Homo sapiens_hsa041501.21292564
23TGF-beta signaling pathway_Homo sapiens_hsa043501.19888244
24Notch signaling pathway_Homo sapiens_hsa043301.18381701
25RNA polymerase_Homo sapiens_hsa030201.17716135
26Glioma_Homo sapiens_hsa052141.17691971
27Dorso-ventral axis formation_Homo sapiens_hsa043201.17476041
28ABC transporters_Homo sapiens_hsa020101.17471215
29Adherens junction_Homo sapiens_hsa045201.17043590
30Pancreatic cancer_Homo sapiens_hsa052121.14925234
31Non-small cell lung cancer_Homo sapiens_hsa052231.13114324
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.12837667
33Inositol phosphate metabolism_Homo sapiens_hsa005621.08341565
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05968592
35AMPK signaling pathway_Homo sapiens_hsa041521.03380800
36Choline metabolism in cancer_Homo sapiens_hsa052310.99246120
37Phospholipase D signaling pathway_Homo sapiens_hsa040720.97289778
38ECM-receptor interaction_Homo sapiens_hsa045120.96641602
39Acute myeloid leukemia_Homo sapiens_hsa052210.93245641
40ErbB signaling pathway_Homo sapiens_hsa040120.93160024
41TNF signaling pathway_Homo sapiens_hsa046680.92895817
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.92496100
43Cell cycle_Homo sapiens_hsa041100.91213201
44Focal adhesion_Homo sapiens_hsa045100.90734789
45Apoptosis_Homo sapiens_hsa042100.90347425
46Endometrial cancer_Homo sapiens_hsa052130.89951432
47GnRH signaling pathway_Homo sapiens_hsa049120.88670605
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.87291181
49Proteoglycans in cancer_Homo sapiens_hsa052050.87111692
50Toxoplasmosis_Homo sapiens_hsa051450.86124726
51mRNA surveillance pathway_Homo sapiens_hsa030150.85776969
52Insulin resistance_Homo sapiens_hsa049310.85307273
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82774788
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82739274
55Insulin signaling pathway_Homo sapiens_hsa049100.80458019
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79657618
57Bladder cancer_Homo sapiens_hsa052190.79043484
58Cholinergic synapse_Homo sapiens_hsa047250.74740941
59Hepatitis B_Homo sapiens_hsa051610.74413266
60p53 signaling pathway_Homo sapiens_hsa041150.72815783
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72031835
62Platelet activation_Homo sapiens_hsa046110.71964753
63HIF-1 signaling pathway_Homo sapiens_hsa040660.71066011
64B cell receptor signaling pathway_Homo sapiens_hsa046620.70793285
65Melanoma_Homo sapiens_hsa052180.70049301
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67141835
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66819136
68Glycerolipid metabolism_Homo sapiens_hsa005610.66766341
69Hippo signaling pathway_Homo sapiens_hsa043900.66269337
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.66055343
71Renal cell carcinoma_Homo sapiens_hsa052110.65829430
72Estrogen signaling pathway_Homo sapiens_hsa049150.65541353
73Vitamin B6 metabolism_Homo sapiens_hsa007500.65468377
74Pathways in cancer_Homo sapiens_hsa052000.64880911
75Influenza A_Homo sapiens_hsa051640.64736308
76Prolactin signaling pathway_Homo sapiens_hsa049170.64653270
77Taste transduction_Homo sapiens_hsa047420.64122272
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63228458
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.63045172
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60813625
81Hepatitis C_Homo sapiens_hsa051600.60539033
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56423826
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.56397864
84Glucagon signaling pathway_Homo sapiens_hsa049220.55711540
85MAPK signaling pathway_Homo sapiens_hsa040100.54838189
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54519513
87Selenocompound metabolism_Homo sapiens_hsa004500.54021926
88Calcium signaling pathway_Homo sapiens_hsa040200.53531604
89Long-term potentiation_Homo sapiens_hsa047200.53098046
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.53043087
91Epstein-Barr virus infection_Homo sapiens_hsa051690.52861419
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.50940385
93Sulfur relay system_Homo sapiens_hsa041220.50717544
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50337520
95Fatty acid biosynthesis_Homo sapiens_hsa000610.50165540
96Tight junction_Homo sapiens_hsa045300.50135211
97Fructose and mannose metabolism_Homo sapiens_hsa000510.46881922
98Rap1 signaling pathway_Homo sapiens_hsa040150.46601383
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46447678
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46405740

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