ANKRD28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.70457282
2central nervous system myelination (GO:0022010)6.70457282
3definitive hemopoiesis (GO:0060216)6.42504688
4leukocyte migration involved in inflammatory response (GO:0002523)5.19908332
5ensheathment of neurons (GO:0007272)5.19407719
6axon ensheathment (GO:0008366)5.19407719
7myelination (GO:0042552)5.14952049
8positive regulation of granulocyte differentiation (GO:0030854)4.45449991
9regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.40550005
10interkinetic nuclear migration (GO:0022027)4.30743190
11mitotic sister chromatid cohesion (GO:0007064)4.27980200
12nuclear pore complex assembly (GO:0051292)4.09215524
13myelin maintenance (GO:0043217)4.06051546
14megakaryocyte development (GO:0035855)4.01931925
15positive regulation of B cell differentiation (GO:0045579)3.98405353
16fatty acid elongation (GO:0030497)3.95793412
17regulation of RNA export from nucleus (GO:0046831)3.93275587
18positive regulation of chromosome segregation (GO:0051984)3.81837543
19myelination in peripheral nervous system (GO:0022011)3.81424187
20peripheral nervous system axon ensheathment (GO:0032292)3.81424187
21astrocyte development (GO:0014002)3.80904486
22negative regulation of neurotransmitter secretion (GO:0046929)3.80003354
23leukocyte aggregation (GO:0070486)3.78109992
24thrombin receptor signaling pathway (GO:0070493)3.77927774
25L-amino acid import (GO:0043092)3.67888771
26cholesterol biosynthetic process (GO:0006695)3.66659949
27mesenchymal-epithelial cell signaling (GO:0060638)3.62851956
28regulation of nucleobase-containing compound transport (GO:0032239)3.59890639
29nuclear pore organization (GO:0006999)3.58793988
30hepatocyte apoptotic process (GO:0097284)3.55162607
31cortical actin cytoskeleton organization (GO:0030866)3.49062231
32protein localization to endosome (GO:0036010)3.46930796
33cytoplasmic mRNA processing body assembly (GO:0033962)3.46217366
34regulation of integrin activation (GO:0033623)3.45870439
35killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.41442878
36disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.41442878
37endothelium development (GO:0003158)3.33894710
38regulation of translational fidelity (GO:0006450)3.32416064
39myelin assembly (GO:0032288)3.31671065
40negative regulation of DNA repair (GO:0045738)3.29074832
41regulation of platelet aggregation (GO:0090330)3.28611042
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.24766133
43creatine metabolic process (GO:0006600)3.23026464
44negative regulation of erythrocyte differentiation (GO:0045647)3.22869056
45protein localization to kinetochore (GO:0034501)3.21498863
46membrane raft organization (GO:0031579)3.20669039
47positive regulation of histone H3-K4 methylation (GO:0051571)3.18211285
48sterol biosynthetic process (GO:0016126)3.17228629
49poly(A)+ mRNA export from nucleus (GO:0016973)3.16554599
50negative regulation of T-helper cell differentiation (GO:0045623)3.14759093
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.14759093
52establishment of mitotic spindle localization (GO:0040001)3.14439020
53DNA unwinding involved in DNA replication (GO:0006268)3.13426814
54regulation of exit from mitosis (GO:0007096)3.12536276
55cellular response to ethanol (GO:0071361)3.11048278
56cortical cytoskeleton organization (GO:0030865)3.09672162
57establishment of mitotic spindle orientation (GO:0000132)3.09070097
58centrosome duplication (GO:0051298)3.07082092
59Golgi to endosome transport (GO:0006895)3.05423035
60pore complex assembly (GO:0046931)3.03696518
61hepatocyte differentiation (GO:0070365)3.03120197
62positive regulation of vasculogenesis (GO:2001214)3.02394622
63L-serine metabolic process (GO:0006563)2.99012611
64defense response to fungus (GO:0050832)2.98234825
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98219305
66regulation of histone H3-K9 methylation (GO:0051570)2.97988139
67negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.97782077
68negative regulation of thymocyte apoptotic process (GO:0070244)2.96610203
69positive regulation of natural killer cell differentiation (GO:0032825)2.95709996
70embryonic hemopoiesis (GO:0035162)2.94513874
71monoubiquitinated protein deubiquitination (GO:0035520)2.93992566
72peptidyl-tyrosine autophosphorylation (GO:0038083)2.93360304
73asymmetric protein localization (GO:0008105)2.91347858
74regulation of establishment of cell polarity (GO:2000114)2.88906021
75neutrophil mediated immunity (GO:0002446)2.88890772
76negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.88703900
77regulation of T-helper 1 cell differentiation (GO:0045625)2.87269806
78histone H3-K4 trimethylation (GO:0080182)2.86480660
79mature B cell differentiation involved in immune response (GO:0002313)2.86354782
80response to lipoprotein particle (GO:0055094)2.86015491
81nerve growth factor signaling pathway (GO:0038180)2.85819170
82growth hormone receptor signaling pathway (GO:0060396)2.82238694
83corticosteroid receptor signaling pathway (GO:0031958)2.80982179
84spindle assembly involved in mitosis (GO:0090307)2.79056589
85mitotic chromosome condensation (GO:0007076)2.78974821
86regulation of lipoprotein metabolic process (GO:0050746)2.78935042
87pinocytosis (GO:0006907)2.78583974
88skin morphogenesis (GO:0043589)2.76846959
89negative regulation of interleukin-8 production (GO:0032717)2.75892176
90sequestering of metal ion (GO:0051238)2.75629244
91NADPH regeneration (GO:0006740)2.74833370
92sister chromatid segregation (GO:0000819)2.74056871
93cytoskeletal anchoring at plasma membrane (GO:0007016)2.73281599
94positive regulation of protein import into nucleus, translocation (GO:0033160)2.72718668
95neutrophil activation involved in immune response (GO:0002283)2.72476250
96regulation of integrin-mediated signaling pathway (GO:2001044)2.71175793
97membrane tubulation (GO:0097320)2.70242425
98activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.70060850
99regulation of platelet activation (GO:0010543)2.68679565
100DNA topological change (GO:0006265)2.68477979
101myeloid cell development (GO:0061515)2.66355998
102lens fiber cell development (GO:0070307)2.66219756
103establishment of spindle orientation (GO:0051294)2.63857460
104cranial suture morphogenesis (GO:0060363)2.60898164
105tyrosine phosphorylation of STAT protein (GO:0007260)2.60634763
106negative regulation of neurotransmitter transport (GO:0051589)2.60468676
107long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.60359804
108response to fungus (GO:0009620)2.59826060
109membrane protein ectodomain proteolysis (GO:0006509)2.59511296
110regulation of DNA endoreduplication (GO:0032875)2.59095488
111regulation of histone H3-K27 methylation (GO:0061085)2.58189788
112glucocorticoid receptor signaling pathway (GO:0042921)2.57691707
113regulation of pigment cell differentiation (GO:0050932)2.57211008
114negative regulation of nitric oxide biosynthetic process (GO:0045019)2.57068497
115semaphorin-plexin signaling pathway (GO:0071526)2.57066524
116regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.56060754
117ether lipid metabolic process (GO:0046485)2.55416945
118mitotic cytokinesis (GO:0000281)2.54902364
119regulation of B cell differentiation (GO:0045577)2.53635062
120cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.52180507
121necroptotic process (GO:0070266)2.51591140
122Rap protein signal transduction (GO:0032486)2.50504019
123import into cell (GO:0098657)2.50458321
124lipid translocation (GO:0034204)2.50078439
125phospholipid translocation (GO:0045332)2.50078439
126response to hepatocyte growth factor (GO:0035728)2.48993898
127cellular response to hepatocyte growth factor stimulus (GO:0035729)2.48993898
128regulation of myelination (GO:0031641)2.48785813
129regulation of mitotic spindle organization (GO:0060236)2.47926094
130cellular response to growth hormone stimulus (GO:0071378)2.47667759
131IMP metabolic process (GO:0046040)2.47223377
132killing of cells of other organism (GO:0031640)2.47193644
133disruption of cells of other organism (GO:0044364)2.47193644
134regulation of erythrocyte differentiation (GO:0045646)2.47153290
135regulation of collateral sprouting (GO:0048670)2.47132142
136regulation of homotypic cell-cell adhesion (GO:0034110)2.46138667
137protein localization to chromosome, centromeric region (GO:0071459)2.45850611
138pentose-phosphate shunt (GO:0006098)2.45738154
139DNA duplex unwinding (GO:0032508)2.44518183
140centrosome localization (GO:0051642)2.43327072
141establishment of spindle localization (GO:0051293)2.42313973
142DNA geometric change (GO:0032392)2.41868991
143positive regulation of Rho protein signal transduction (GO:0035025)2.41860505
144mRNA transcription (GO:0009299)2.41819314
145positive regulation of natural killer cell activation (GO:0032816)2.41318208
146microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.40990022
147amino acid import (GO:0043090)2.38774609
148sister chromatid cohesion (GO:0007062)2.37904026
149protein localization to cell surface (GO:0034394)2.37541467
150chondrocyte development (GO:0002063)2.37453279
151NLS-bearing protein import into nucleus (GO:0006607)2.37120196
152negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.36666062
153negative regulation of skeletal muscle tissue development (GO:0048642)2.35284776
154Leydig cell differentiation (GO:0033327)2.35274172
155platelet-derived growth factor receptor signaling pathway (GO:0048008)2.35224797
156ribosome assembly (GO:0042255)2.34278355
157regulation of granulocyte differentiation (GO:0030852)2.33548239
158mature B cell differentiation (GO:0002335)2.32787903
159regulation of inositol phosphate biosynthetic process (GO:0010919)2.31247606
160glycoprotein catabolic process (GO:0006516)2.30921580
161protein K11-linked deubiquitination (GO:0035871)2.30905318
162mitotic G2 DNA damage checkpoint (GO:0007095)2.29989878
163positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.29409760
164positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.29246462
165DNA synthesis involved in DNA repair (GO:0000731)2.28211024
166interleukin-6-mediated signaling pathway (GO:0070102)2.28087202
167regulation of fibroblast migration (GO:0010762)2.27809855
168regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.27745238
169positive regulation of developmental pigmentation (GO:0048087)2.27703223
170B cell receptor signaling pathway (GO:0050853)2.27403101
171positive regulation of steroid hormone secretion (GO:2000833)2.27142015
172dosage compensation (GO:0007549)2.25949800
173hypotonic response (GO:0006971)2.25584568
174retrograde transport, vesicle recycling within Golgi (GO:0000301)2.25229887
175positive regulation of cardiac muscle hypertrophy (GO:0010613)2.24742256
176positive regulation of muscle hypertrophy (GO:0014742)2.24742256
177hemoglobin metabolic process (GO:0020027)2.24364576
178B cell differentiation (GO:0030183)2.24237306
179hematopoietic stem cell proliferation (GO:0071425)2.24216736
180positive regulation of fibroblast migration (GO:0010763)2.23852986
181angiogenesis involved in wound healing (GO:0060055)2.22640620
182platelet aggregation (GO:0070527)2.21726573
183prenylation (GO:0097354)2.21573966
184protein prenylation (GO:0018342)2.21573966
185peptidyl-lysine trimethylation (GO:0018023)2.21316509
186positive regulation of protein autophosphorylation (GO:0031954)2.20300935

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.67326267
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.13832739
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.65891624
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.58232596
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.42576721
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.87125062
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70427793
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.57791261
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.49070863
10AR_21909140_ChIP-Seq_LNCAP_Human2.34784142
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32811318
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31543175
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29711375
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.29669590
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29636568
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.17673745
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.14550990
18SCL_19346495_ChIP-Seq_HPC-7_Human2.03893422
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.95952129
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.95542952
21TP53_16413492_ChIP-PET_HCT116_Human1.94048752
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.89788149
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88986511
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71733414
25AR_21572438_ChIP-Seq_LNCaP_Human1.70321809
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65555923
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.64749497
28* FOXO3_23340844_ChIP-Seq_DLD1_Human1.62750468
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62128025
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59177540
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58624174
32VDR_21846776_ChIP-Seq_THP-1_Human1.57671060
33SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55207261
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51722868
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.49961605
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.46864076
37SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46548983
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46419783
39* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45888274
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.44773977
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.44485039
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44012505
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43036592
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41479190
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39956214
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39410575
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39017888
48RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36347630
49SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35043784
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33836392
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.31806194
52* BRD4_25478319_ChIP-Seq_HGPS_Human1.31790272
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31329754
54GBX2_23144817_ChIP-Seq_PC3_Human1.30662354
55P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30589214
56VDR_24763502_ChIP-Seq_THP-1_Human1.29902083
57IGF1R_20145208_ChIP-Seq_DFB_Human1.29640916
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28903185
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28618299
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27411637
61ELK1_19687146_ChIP-ChIP_HELA_Human1.27042725
62GATA2_19941826_ChIP-Seq_K562_Human1.26994336
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.26546310
64TCF7_22412390_ChIP-Seq_EML_Mouse1.25875185
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25757859
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.24772860
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22969503
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20979287
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20242558
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20205306
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20205306
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19881312
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19113783
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17703988
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15230907
76CLOCK_20551151_ChIP-Seq_293T_Human1.14105341
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14017565
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13866620
79RUNX_20019798_ChIP-Seq_JUKART_Human1.13336833
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12933529
81ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12703437
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.12029725
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11824918
84FUS_26573619_Chip-Seq_HEK293_Human1.11591796
85* STAT3_23295773_ChIP-Seq_U87_Human1.11087927
86* MYC_22102868_ChIP-Seq_BL_Human1.11000214
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.10985887
88* ER_23166858_ChIP-Seq_MCF-7_Human1.09388504
89* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09010791
90KDM2B_26808549_Chip-Seq_DND41_Human1.07900028
91GATA3_26560356_Chip-Seq_TH2_Human1.06602441
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06583484
93SALL4_22934838_ChIP-ChIP_CD34+_Human1.03968969
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03758368
95* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03370200
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03151592
97SMAD4_21799915_ChIP-Seq_A2780_Human1.02610236
98TP53_22127205_ChIP-Seq_IMR90_Human1.01520448
99* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01166104
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00251560
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98810233
102GATA3_27048872_Chip-Seq_THYMUS_Human0.98722681
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98299757
104VDR_22108803_ChIP-Seq_LS180_Human0.98206801
105SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98176573
106CDX2_22108803_ChIP-Seq_LS180_Human0.97693864
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97146943
108GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96669583
109* SPI1_23127762_ChIP-Seq_K562_Human0.96489168
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96471275
111FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96220345
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96043561
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95974232
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95879268
115NFE2_27457419_Chip-Seq_LIVER_Mouse0.95042353
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94792083
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94538273
118PU_27001747_Chip-Seq_BMDM_Mouse0.94344384
119GATA2_21666600_ChIP-Seq_HMVEC_Human0.94296808
120GATA1_19941826_ChIP-Seq_K562_Human0.94151175
121CMYC_18555785_Chip-Seq_ESCs_Mouse0.93483112
122* FLI1_21867929_ChIP-Seq_TH2_Mouse0.93070309
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91572686
124P53_22387025_ChIP-Seq_ESCs_Mouse0.91506436
125VDR_24787735_ChIP-Seq_THP-1_Human0.90885236
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89716248
127* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89156457
128* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.89156457
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89144693
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88696636
131* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87760389
132EWS_26573619_Chip-Seq_HEK293_Human0.87491126
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86241672
134MYB_26560356_Chip-Seq_TH2_Human0.85926866
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85666104
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85392305
137GATA1_22025678_ChIP-Seq_K562_Human0.85073172
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85009491
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.84407752
140CJUN_26792858_Chip-Seq_BT549_Human0.84124780
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.83886570
142MYB_26560356_Chip-Seq_TH1_Human0.83073207
143UTX_26944678_Chip-Seq_JUKART_Human0.82748927
144SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.82690656
145GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82300077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology3.71111027
2MP0000920_abnormal_myelination3.69008552
3MP0003950_abnormal_plasma_membrane3.04569728
4MP0004134_abnormal_chest_morphology2.94468588
5MP0008438_abnormal_cutaneous_collagen2.82071548
6MP0005623_abnormal_meninges_morphology2.70544772
7MP0002009_preneoplasia2.62592977
8MP0003690_abnormal_glial_cell2.59407484
9MP0003705_abnormal_hypodermis_morpholog2.55666214
10MP0000015_abnormal_ear_pigmentation2.55079047
11MP0003828_pulmonary_edema2.40091508
12MP0010307_abnormal_tumor_latency2.38436086
13MP0000569_abnormal_digit_pigmentation2.35592431
14MP0000733_abnormal_muscle_development2.33171498
15MP0004185_abnormal_adipocyte_glucose2.19150299
16MP0005171_absent_coat_pigmentation2.13108903
17MP0003300_gastrointestinal_ulcer2.09994369
18MP0001545_abnormal_hematopoietic_system2.08112354
19MP0005397_hematopoietic_system_phenotyp2.08112354
20MP0005174_abnormal_tail_pigmentation2.05223809
21MP0004885_abnormal_endolymph2.04629695
22MP0010678_abnormal_skin_adnexa2.00531996
23MP0001299_abnormal_eye_distance/2.00134479
24MP0010352_gastrointestinal_tract_polyps1.98362749
25MP0001835_abnormal_antigen_presentation1.96882655
26MP0000372_irregular_coat_pigmentation1.94338623
27MP0008057_abnormal_DNA_replication1.93585337
28MP0005408_hypopigmentation1.88287369
29MP0008007_abnormal_cellular_replicative1.84821148
30MP0004084_abnormal_cardiac_muscle1.81773763
31MP0002877_abnormal_melanocyte_morpholog1.79734867
32MP0003632_abnormal_nervous_system1.73010498
33MP0003806_abnormal_nucleotide_metabolis1.70921599
34MP0009384_cardiac_valve_regurgitation1.68587779
35MP0003566_abnormal_cell_adhesion1.67545956
36MP0003763_abnormal_thymus_physiology1.65221220
37MP0000383_abnormal_hair_follicle1.62616728
38MP0000747_muscle_weakness1.61911906
39MP0003303_peritoneal_inflammation1.61117445
40MP0000013_abnormal_adipose_tissue1.58028641
41MP0004197_abnormal_fetal_growth/weight/1.54029488
42MP0001853_heart_inflammation1.54000260
43MP0003091_abnormal_cell_migration1.52804394
44MP0005503_abnormal_tendon_morphology1.51666656
45MP0002396_abnormal_hematopoietic_system1.51502826
46MP0004036_abnormal_muscle_relaxation1.48675648
47MP0010094_abnormal_chromosome_stability1.43103084
48MP0009697_abnormal_copulation1.40958753
49MP0005076_abnormal_cell_differentiation1.40530908
50MP0010368_abnormal_lymphatic_system1.39671476
51MP0009278_abnormal_bone_marrow1.39354939
52MP0002108_abnormal_muscle_morphology1.39010014
53MP0000462_abnormal_digestive_system1.38931569
54MP0001730_embryonic_growth_arrest1.38444796
55MP0005275_abnormal_skin_tensile1.38326660
56MP0002089_abnormal_postnatal_growth/wei1.38237161
57MP0001851_eye_inflammation1.36020202
58MP0001661_extended_life_span1.34670528
59MP0003634_abnormal_glial_cell1.34552908
60MP0002006_tumorigenesis1.33555223
61MP0001915_intracranial_hemorrhage1.33442676
62MP0002398_abnormal_bone_marrow1.32923091
63MP0000465_gastrointestinal_hemorrhage1.31889232
64MP0003937_abnormal_limbs/digits/tail_de1.28131590
65MP0001879_abnormal_lymphatic_vessel1.23592151
66MP0001485_abnormal_pinna_reflex1.23545782
67MP0002282_abnormal_trachea_morphology1.22938890
68MP0003172_abnormal_lysosome_physiology1.22693794
69MP0004484_altered_response_of1.22575240
70MP0003111_abnormal_nucleus_morphology1.20883981
71MP0003077_abnormal_cell_cycle1.19790895
72MP0002095_abnormal_skin_pigmentation1.19680078
73MP0005075_abnormal_melanosome_morpholog1.18554502
74MP0005023_abnormal_wound_healing1.18354614
75MP0003656_abnormal_erythrocyte_physiolo1.16513735
76MP0002933_joint_inflammation1.15815849
77MP0004808_abnormal_hematopoietic_stem1.15511643
78MP0003279_aneurysm1.15078715
79MP0009703_decreased_birth_body1.14866276
80MP0005165_increased_susceptibility_to1.14531196
81MP0003436_decreased_susceptibility_to1.14034279
82MP0002148_abnormal_hypersensitivity_rea1.12659530
83MP0004272_abnormal_basement_membrane1.11422128
84MP0003045_fibrosis1.10225776
85MP0002060_abnormal_skin_morphology1.08175536
86MP0005000_abnormal_immune_tolerance1.05671861
87MP0000689_abnormal_spleen_morphology1.04487912
88MP0008004_abnormal_stomach_pH1.03780874
89MP0002722_abnormal_immune_system1.02676181
90MP0004087_abnormal_muscle_fiber1.01758526
91MP0009672_abnormal_birth_weight1.01734320
92MP0000371_diluted_coat_color1.01315262
93MP0004742_abnormal_vestibular_system1.01249323
94MP0001958_emphysema1.00712753
95MP0000681_abnormal_thyroid_gland0.96316683
96MP0006054_spinal_hemorrhage0.96296821
97MP0003329_amyloid_beta_deposits0.95838251
98MP0002084_abnormal_developmental_patter0.95540478
99MP0002019_abnormal_tumor_incidence0.95325260
100MP0000432_abnormal_head_morphology0.94129559
101MP0000377_abnormal_hair_follicle0.93830519
102MP0000703_abnormal_thymus_morphology0.93302679
103MP0002086_abnormal_extraembryonic_tissu0.92266479
104MP0003252_abnormal_bile_duct0.91367435
105MP0004381_abnormal_hair_follicle0.91361476
106MP0000428_abnormal_craniofacial_morphol0.91351667
107MP0003984_embryonic_growth_retardation0.90227635
108MP0000350_abnormal_cell_proliferation0.89439625
109MP0003448_altered_tumor_morphology0.89294070
110MP0010630_abnormal_cardiac_muscle0.88486787
111MP0001672_abnormal_embryogenesis/_devel0.88264977
112MP0005380_embryogenesis_phenotype0.88264977
113MP0002925_abnormal_cardiovascular_devel0.87488084
114MP0002998_abnormal_bone_remodeling0.86333133
115MP0005621_abnormal_cell_physiology0.85729337
116MP0005409_darkened_coat_color0.85669508
117MP0002092_abnormal_eye_morphology0.85610436
118MP0002419_abnormal_innate_immunity0.85439429
119MP0001177_atelectasis0.83993552
120MP0002088_abnormal_embryonic_growth/wei0.83945954
121MP0004947_skin_inflammation0.83156592
122MP0002085_abnormal_embryonic_tissue0.83004208
123MP0002332_abnormal_exercise_endurance0.82918114
124MP0000604_amyloidosis0.82724351
125MP0010234_abnormal_vibrissa_follicle0.81650868
126MP0002429_abnormal_blood_cell0.81495744
127MP0002452_abnormal_antigen_presenting0.81364963
128MP0002420_abnormal_adaptive_immunity0.80534513
129MP0000716_abnormal_immune_system0.80439854
130MP0001293_anophthalmia0.80248415
131MP0001243_abnormal_dermal_layer0.79987905
132MP0000762_abnormal_tongue_morphology0.79260924
133MP0001697_abnormal_embryo_size0.79240132
134MP0008775_abnormal_heart_ventricle0.78755924
135MP0008058_abnormal_DNA_repair0.78182826
136MP0003631_nervous_system_phenotype0.78102882
137MP0001819_abnormal_immune_cell0.78045358
138MP0002723_abnormal_immune_serum0.77579343
139MP0002896_abnormal_bone_mineralization0.77114798
140MP0003943_abnormal_hepatobiliary_system0.77004362
141MP0001191_abnormal_skin_condition0.76798847
142MP0001800_abnormal_humoral_immune0.76578691
143MP0005666_abnormal_adipose_tissue0.76331244
144MP0002405_respiratory_system_inflammati0.76230383
145MP0000163_abnormal_cartilage_morphology0.75770917
146MP0005164_abnormal_response_to0.75263294
147MP0001533_abnormal_skeleton_physiology0.75178479
148MP0002113_abnormal_skeleton_development0.75058990
149MP0002115_abnormal_skeleton_extremities0.74574312
150MP0000249_abnormal_blood_vessel0.74365465
151MP0002166_altered_tumor_susceptibility0.74251400
152MP0009780_abnormal_chondrocyte_physiolo0.74092555
153MP0005388_respiratory_system_phenotype0.73015042
154MP0002133_abnormal_respiratory_system0.73015042
155MP0010155_abnormal_intestine_physiology0.72682349
156MP0005595_abnormal_vascular_smooth0.72561384
157MP0003755_abnormal_palate_morphology0.71678503
158MP0009250_abnormal_appendicular_skeleto0.71171534
159MP0002128_abnormal_blood_circulation0.71006938
160MP0002080_prenatal_lethality0.70509621
161MP0001784_abnormal_fluid_regulation0.70122631
162MP0003567_abnormal_fetal_cardiomyocyte0.70086913
163MP0009764_decreased_sensitivity_to0.68276418
164MP0003191_abnormal_cellular_cholesterol0.68099846
165MP0002075_abnormal_coat/hair_pigmentati0.64791905

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.68840554
2Epiphyseal dysplasia (HP:0002656)4.51411852
3Acute myeloid leukemia (HP:0004808)4.49844965
4Spondylolisthesis (HP:0003302)4.33534585
5Degeneration of the lateral corticospinal tracts (HP:0002314)4.04355872
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.04355872
7Small epiphyses (HP:0010585)3.89065121
8Acute lymphatic leukemia (HP:0006721)3.81997270
9Dyschromatopsia (HP:0007641)3.76513960
10Autoimmune hemolytic anemia (HP:0001890)3.70566966
11Hypoplastic ischia (HP:0003175)3.68886660
12Abnormal platelet volume (HP:0011876)3.68050597
13Short middle phalanx of the 5th finger (HP:0004220)3.63197456
14Epistaxis (HP:0000421)3.59901952
15Metaphyseal cupping (HP:0003021)3.47918195
16Menorrhagia (HP:0000132)3.19575387
17Thrombocytosis (HP:0001894)3.18773412
18Insidious onset (HP:0003587)3.18299506
19Termporal pattern (HP:0011008)3.18299506
20Abnormality of the ischium (HP:0003174)3.10184146
21Petechiae (HP:0000967)3.00021150
22Abnormality of the corticospinal tract (HP:0002492)2.97657072
23Ulnar bowing (HP:0003031)2.96165279
24Gingival bleeding (HP:0000225)2.89066167
25Abnormal platelet function (HP:0011869)2.87818405
26Impaired platelet aggregation (HP:0003540)2.87818405
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.87340928
28Sensory axonal neuropathy (HP:0003390)2.87150184
29Relative macrocephaly (HP:0004482)2.82035971
30Aortic aneurysm (HP:0004942)2.77321928
31Abnormality of the prostate (HP:0008775)2.76870480
32Irregular epiphyses (HP:0010582)2.74832395
33Cupped ribs (HP:0000887)2.72449210
34Mild short stature (HP:0003502)2.70872151
35Submucous cleft hard palate (HP:0000176)2.69453315
36Delayed closure of the anterior fontanelle (HP:0001476)2.69349383
37Abnormal foot bone ossification (HP:0010675)2.63949286
38Fatigue (HP:0012378)2.62966918
39Albinism (HP:0001022)2.62614713
40Absent frontal sinuses (HP:0002688)2.59905699
41Papillary thyroid carcinoma (HP:0002895)2.54920265
42Hypoplastic pelvis (HP:0008839)2.54386843
43Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.51165740
44Deep philtrum (HP:0002002)2.48260902
45Prostate neoplasm (HP:0100787)2.48119762
46Vertebral clefting (HP:0008428)2.45294144
47Delayed epiphyseal ossification (HP:0002663)2.42345787
48Limited elbow extension (HP:0001377)2.40889717
49Viral hepatitis (HP:0006562)2.39180093
50Conjunctival telangiectasia (HP:0000524)2.38983301
51Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37180936
52Abnormal vertebral ossification (HP:0100569)2.36075265
53Premature rupture of membranes (HP:0001788)2.35962965
54Cutaneous melanoma (HP:0012056)2.35731831
55Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.34776987
56Macroorchidism (HP:0000053)2.31773979
57Abnormal auditory evoked potentials (HP:0006958)2.31014237
58Osteolytic defects of the hand bones (HP:0009699)2.30266675
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.30266675
60Nemaline bodies (HP:0003798)2.25115191
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.24661473
62Narrow palate (HP:0000189)2.23712253
63Decreased skull ossification (HP:0004331)2.22806112
64Aortic dissection (HP:0002647)2.22562180
65Coronal craniosynostosis (HP:0004440)2.18699787
66Vitreoretinal degeneration (HP:0000655)2.18617808
67Myelodysplasia (HP:0002863)2.18161086
68Premature skin wrinkling (HP:0100678)2.18087848
69Large earlobe (HP:0009748)2.17825322
70Prominent nose (HP:0000448)2.16925150
71Rhizomelia (HP:0008905)2.16814687
72Generalized hypopigmentation of hair (HP:0011358)2.16561559
73Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16421170
74Short 4th metacarpal (HP:0010044)2.16112792
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.16112792
76Peripheral hypomyelination (HP:0007182)2.15615542
77Glucose intolerance (HP:0000833)2.14419793
78Stillbirth (HP:0003826)2.11857593
79Depressed nasal tip (HP:0000437)2.08171136
80Sandal gap (HP:0001852)2.05631263
81Abnormality of B cell number (HP:0010975)2.05102297
82Scapular winging (HP:0003691)2.04110541
83Spastic gait (HP:0002064)2.03916212
84Volvulus (HP:0002580)2.03072339
85Flat acetabular roof (HP:0003180)2.02950037
86Hypoplastic iliac wings (HP:0002866)2.02663754
87Shallow orbits (HP:0000586)2.02271066
88Tetraparesis (HP:0002273)2.01145154
89Abnormality of T cell physiology (HP:0011840)2.00957199
90Abnormality of the left ventricular outflow tract (HP:0011103)2.00911815
91Subaortic stenosis (HP:0001682)2.00911815
92Arterial thrombosis (HP:0004420)2.00021017
93Onion bulb formation (HP:0003383)1.99418683
94Ankyloglossia (HP:0010296)1.98514004
95Central scotoma (HP:0000603)1.97215045
96Deviation of the thumb (HP:0009603)1.96351252
97Granulocytopenia (HP:0001913)1.96068943
98Short chin (HP:0000331)1.95923694
99Exostoses (HP:0100777)1.95838413
100Eosinophilia (HP:0001880)1.95673717
101Fair hair (HP:0002286)1.94972176
102Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.94577915
103Thickened calvaria (HP:0002684)1.94390460
104Abnormality of the calcaneus (HP:0008364)1.94331204
105Cystic hygroma (HP:0000476)1.94282942
106Hypopigmentation of the fundus (HP:0007894)1.93825461
107Tibial bowing (HP:0002982)1.93786077
108Thyroid carcinoma (HP:0002890)1.93621072
109Neoplasm of the oral cavity (HP:0100649)1.93264820
110Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91546040
111Abnormality of oral frenula (HP:0000190)1.90197014
112Ocular albinism (HP:0001107)1.90103060
113Bruising susceptibility (HP:0000978)1.89986979
114Menstrual irregularities (HP:0000858)1.89831842
115Abnormality of skull ossification (HP:0002703)1.89726991
116Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88903911
117Metaphyseal dysplasia (HP:0100255)1.87987204
118Ankle contracture (HP:0006466)1.87926259
119Persistence of primary teeth (HP:0006335)1.87601782
120Difficulty running (HP:0009046)1.87569678
121Chest pain (HP:0100749)1.87068090
122Long clavicles (HP:0000890)1.86713456
123Thoracolumbar scoliosis (HP:0002944)1.86355642
124Abnormality of T cell number (HP:0011839)1.86062369
125Intention tremor (HP:0002080)1.85880994
126Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.84605465
127Wormian bones (HP:0002645)1.84571521
128Proximal placement of thumb (HP:0009623)1.83506015
129Widely spaced teeth (HP:0000687)1.80701445
130Infantile muscular hypotonia (HP:0008947)1.80476349
131Blue irides (HP:0000635)1.79754032
132Abnormal tarsal ossification (HP:0008369)1.79455222
133Abnormality of the frontal sinuses (HP:0002687)1.79158827
134Subacute progressive viral hepatitis (HP:0006572)1.79117413
135Abnormality of the lumbar spine (HP:0100712)1.77569010
136Slender build (HP:0001533)1.77248339
137Bell-shaped thorax (HP:0001591)1.76393350
138Dilatation of the ascending aorta (HP:0005111)1.76288021
139Hyporeflexia of lower limbs (HP:0002600)1.75969255
140B lymphocytopenia (HP:0010976)1.75393467
141Barrel-shaped chest (HP:0001552)1.75238391
142Disproportionate tall stature (HP:0001519)1.73815387
143Spontaneous hematomas (HP:0007420)1.72772795
144Duplicated collecting system (HP:0000081)1.72765411
145Autoimmune thrombocytopenia (HP:0001973)1.72179894
146White forelock (HP:0002211)1.71976624
147Hypoplasia of the iris (HP:0007676)1.71848333
148Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.71676216
149Anteriorly placed anus (HP:0001545)1.71573684
150Recurrent viral infections (HP:0004429)1.70862431
151Muscle fiber inclusion bodies (HP:0100299)1.70697820
152Aqueductal stenosis (HP:0002410)1.70536432
153Spinal cord lesions (HP:0100561)1.69948596
154Syringomyelia (HP:0003396)1.69948596
155Hypoplasia of the odontoid process (HP:0003311)1.69859328
156Cone-rod dystrophy (HP:0000548)1.68268527
157Increased mean platelet volume (HP:0011877)1.68231872
158Amaurosis fugax (HP:0100576)1.68127685
159Absent epiphyses (HP:0010577)1.67971326
160Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67971326
161Heterotopia (HP:0002282)1.67315630
162Distal arthrogryposis (HP:0005684)1.67285514
163Abnormality of the epiphyses of the hand (HP:0005924)1.66544204
164Mucosal telangiectasiae (HP:0100579)1.65941466
165Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.65774627
166Alacrima (HP:0000522)1.64290921
167Cerebral inclusion bodies (HP:0100314)1.63484815
168Esophageal atresia (HP:0002032)1.62859305
169Abnormal ossification of hand bones (HP:0005921)1.61243783
170Abnormality of the odontoid process (HP:0003310)1.58843969
171Stridor (HP:0010307)1.58147119
172Neurofibrillary tangles (HP:0002185)1.57870738
173Cervical subluxation (HP:0003308)1.57396916
174Bowing of the arm (HP:0006488)1.56834779
175Bowed forearm bones (HP:0003956)1.56834779
176Urinary urgency (HP:0000012)1.56831004
177Akinesia (HP:0002304)1.56755229
178Coxa vara (HP:0002812)1.56306727
179Slow saccadic eye movements (HP:0000514)1.56278851
180Abnormality of the proximal phalanges of the hand (HP:0009834)1.54556753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.86738869
2STK393.58465254
3EIF2AK33.38879014
4TEC3.07626960
5ICK2.85952611
6BMPR22.82960800
7FGFR22.77669599
8FRK2.55100956
9PIK3CG2.54982556
10TTN2.52904023
11LATS12.46468645
12TAOK32.44358680
13MST42.41062338
14EEF2K2.39338258
15CDK122.35935537
16PKN22.31400008
17KIT2.31031142
18ERBB32.26078941
19OXSR12.24371669
20TESK22.12667924
21CDC72.00310214
22MET1.90694759
23MKNK21.85963521
24TYRO31.79964645
25AKT31.75175637
26CLK11.67301224
27STK31.65021376
28MAP3K141.64585797
29BTK1.50266521
30DDR21.47814466
31WNK11.46253881
32SIK31.44192569
33BMX1.42150029
34TRIB31.39970081
35EIF2AK11.38526438
36TRPM71.34027098
37BRSK21.33139263
38PLK21.33118294
39CAMK1G1.31769748
40PDGFRB1.29945227
41DMPK1.25505397
42ALK1.25435458
43CSNK1A1L1.23772837
44MAP2K31.22376584
45CDK61.19855055
46TNIK1.16507874
47WEE11.13104623
48FER1.09712753
49CDK81.09420330
50PNCK1.08289809
51CSNK1D1.07806686
52NEK91.07796719
53LIMK11.05779986
54MKNK11.05771146
55EIF2AK21.05735244
56STK241.05138643
57MUSK1.04390036
58PTK61.03860583
59MTOR1.01995057
60PAK21.00891589
61IKBKB0.98713082
62RPS6KB20.97073950
63CAMK1D0.96681616
64IRAK10.96622192
65NEK20.96378949
66SYK0.95718955
67BRD40.95100374
68TRIM280.94835309
69ROCK20.94733230
70SCYL20.94669491
71FES0.93245099
72TTK0.92500017
73FGFR10.90287752
74STK100.90147393
75ACVR1B0.88573693
76PRPF4B0.87363139
77IRAK30.86943907
78JAK10.85948883
79MELK0.85810385
80MOS0.85192692
81PDK20.84531155
82PKN10.83831329
83MARK30.83516481
84STK38L0.83470746
85MAP3K60.82786428
86CHEK10.82233717
87CSNK1G30.80390564
88PTK2B0.79135724
89PAK60.78591720
90MYLK0.78339241
91MAP3K80.76859468
92UHMK10.76720387
93MAPK110.76698316
94PBK0.76453847
95CSNK1G20.75945745
96NEK60.75779506
97CSNK1G10.75353683
98BMPR1B0.72412272
99ZAP700.70912053
100ABL10.69224386
101RET0.67925256
102CDK40.67693527
103PDGFRA0.66424639
104TGFBR20.66337679
105ATR0.66198239
106STK40.64712399
107MAP3K20.64007662
108MAPKAPK50.63453562
109RIPK40.63434097
110PRKCQ0.62187906
111ERBB40.61492154
112PDPK10.61237982
113ATM0.60469104
114HIPK20.60029453
115NUAK10.59892826
116SIK10.59810092
117MAPK70.59583227
118PLK40.59295485
119NLK0.58744119
120PAK40.57894760
121FGR0.57121677
122CDK90.55504292
123TBK10.55438563
124PDK10.55259966
125FGFR30.53380101
126CDK10.53348518
127MAP3K130.52821693
128FLT30.50956637
129CSK0.50934264
130LRRK20.50457008
131IRAK40.49997449
132CSF1R0.47577164
133TAOK10.47463774
134STK110.47135618
135SGK30.46813126
136IGF1R0.45206883
137ITK0.44960202
138JAK30.44774187
139MAP2K10.44626678
140CDK20.44234976
141CDK70.44142156
142RIPK10.43877493
143NTRK10.43747379
144CHEK20.42555082
145FYN0.42220792
146IKBKE0.42030562
147BCR0.41236874
148MAPK100.40976639
149PIK3CA0.40904426
150ADRBK10.40839837
151TGFBR10.40297844
152PRKCH0.40261242
153PLK30.40020849
154ABL20.40009068
155OBSCN0.39678043
156PRKDC0.39486098
157CDK150.38294272
158MAPK10.38123106
159HCK0.38080168
160CCNB10.37871333
161MARK20.37704466
162MAPK30.37598980
163BRSK10.37055265
164MAP3K30.35858806
165MAPKAPK30.35778882

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.49397142
2Steroid biosynthesis_Homo sapiens_hsa001003.43402690
3Nitrogen metabolism_Homo sapiens_hsa009102.92815490
4ECM-receptor interaction_Homo sapiens_hsa045122.07109522
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.05996579
6Lysine degradation_Homo sapiens_hsa003101.85856793
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.84641990
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73735949
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.69607416
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68380188
11MicroRNAs in cancer_Homo sapiens_hsa052061.65479799
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64500562
13Focal adhesion_Homo sapiens_hsa045101.63788274
14Fatty acid elongation_Homo sapiens_hsa000621.46705875
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44995188
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43225395
17Renal cell carcinoma_Homo sapiens_hsa052111.42942683
18Proteoglycans in cancer_Homo sapiens_hsa052051.37012691
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35458722
20Chronic myeloid leukemia_Homo sapiens_hsa052201.33599445
21Non-homologous end-joining_Homo sapiens_hsa034501.33238485
22Asthma_Homo sapiens_hsa053101.31660156
23Hepatitis B_Homo sapiens_hsa051611.30129542
24Small cell lung cancer_Homo sapiens_hsa052221.28743193
25Ether lipid metabolism_Homo sapiens_hsa005651.27866515
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.26559346
27Non-small cell lung cancer_Homo sapiens_hsa052231.20373414
28Platelet activation_Homo sapiens_hsa046111.19627453
29Measles_Homo sapiens_hsa051621.18584226
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.17038889
31Hematopoietic cell lineage_Homo sapiens_hsa046401.16750267
32p53 signaling pathway_Homo sapiens_hsa041151.15787651
33Vitamin B6 metabolism_Homo sapiens_hsa007501.15649149
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15505935
35Axon guidance_Homo sapiens_hsa043601.13378462
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.13091709
37Circadian rhythm_Homo sapiens_hsa047101.12486193
38Central carbon metabolism in cancer_Homo sapiens_hsa052301.11692308
39Dorso-ventral axis formation_Homo sapiens_hsa043201.09247074
40Prostate cancer_Homo sapiens_hsa052151.09109943
41T cell receptor signaling pathway_Homo sapiens_hsa046601.08759790
42One carbon pool by folate_Homo sapiens_hsa006701.06575315
43Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06314737
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04416969
45TNF signaling pathway_Homo sapiens_hsa046681.04255641
46Cell cycle_Homo sapiens_hsa041101.02758086
47mTOR signaling pathway_Homo sapiens_hsa041501.02499949
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01622133
49Sulfur metabolism_Homo sapiens_hsa009201.00478743
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00116840
51Fatty acid biosynthesis_Homo sapiens_hsa000610.96858079
52Fatty acid metabolism_Homo sapiens_hsa012120.96470644
53Glioma_Homo sapiens_hsa052140.96280805
54Sphingolipid signaling pathway_Homo sapiens_hsa040710.95619636
55Pancreatic cancer_Homo sapiens_hsa052120.95585373
56PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94983822
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93396416
58B cell receptor signaling pathway_Homo sapiens_hsa046620.92228859
59Legionellosis_Homo sapiens_hsa051340.91946470
60Tight junction_Homo sapiens_hsa045300.91418773
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.91092179
62Herpes simplex infection_Homo sapiens_hsa051680.90488939
63Leishmaniasis_Homo sapiens_hsa051400.90237268
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88541703
65ErbB signaling pathway_Homo sapiens_hsa040120.87941888
66Influenza A_Homo sapiens_hsa051640.87485821
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86101712
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85473073
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.85193521
70Amoebiasis_Homo sapiens_hsa051460.84917837
71Viral carcinogenesis_Homo sapiens_hsa052030.83930820
72TGF-beta signaling pathway_Homo sapiens_hsa043500.81401628
73Renin secretion_Homo sapiens_hsa049240.81018148
74VEGF signaling pathway_Homo sapiens_hsa043700.79940657
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79698110
76Adherens junction_Homo sapiens_hsa045200.78130787
77Gap junction_Homo sapiens_hsa045400.76033953
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.75458056
79mRNA surveillance pathway_Homo sapiens_hsa030150.75244355
80Choline metabolism in cancer_Homo sapiens_hsa052310.74356818
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73321761
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.72533069
83Allograft rejection_Homo sapiens_hsa053300.71074299
84AMPK signaling pathway_Homo sapiens_hsa041520.70579095
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69130986
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68384425
87Malaria_Homo sapiens_hsa051440.67236452
88Apoptosis_Homo sapiens_hsa042100.67170035
89Systemic lupus erythematosus_Homo sapiens_hsa053220.67041055
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66158328
91Prolactin signaling pathway_Homo sapiens_hsa049170.65834339
92Fanconi anemia pathway_Homo sapiens_hsa034600.64915257
93Starch and sucrose metabolism_Homo sapiens_hsa005000.64877691
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64803386
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.64715160
96African trypanosomiasis_Homo sapiens_hsa051430.63372108
97Insulin resistance_Homo sapiens_hsa049310.63160607
98Endocytosis_Homo sapiens_hsa041440.62569002
99Pathways in cancer_Homo sapiens_hsa052000.62346458
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62171976
101Salivary secretion_Homo sapiens_hsa049700.62144951
102Endometrial cancer_Homo sapiens_hsa052130.61855490
103Viral myocarditis_Homo sapiens_hsa054160.60785213
104Pentose phosphate pathway_Homo sapiens_hsa000300.60308100
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.60276118
106Calcium signaling pathway_Homo sapiens_hsa040200.59987710
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59940151
108Nucleotide excision repair_Homo sapiens_hsa034200.59552877
109Pancreatic secretion_Homo sapiens_hsa049720.58356060
110Sphingolipid metabolism_Homo sapiens_hsa006000.58120490
111Thyroid cancer_Homo sapiens_hsa052160.57749227
112HTLV-I infection_Homo sapiens_hsa051660.57305554
113Rap1 signaling pathway_Homo sapiens_hsa040150.56847544
114Graft-versus-host disease_Homo sapiens_hsa053320.56175590
115Inositol phosphate metabolism_Homo sapiens_hsa005620.55992268
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55747504
117Selenocompound metabolism_Homo sapiens_hsa004500.55575841
118RNA transport_Homo sapiens_hsa030130.55078741
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54219206
120Ovarian steroidogenesis_Homo sapiens_hsa049130.53947406
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53176019
122Histidine metabolism_Homo sapiens_hsa003400.52040428
123Melanoma_Homo sapiens_hsa052180.51090277
124Acute myeloid leukemia_Homo sapiens_hsa052210.50705126
125MAPK signaling pathway_Homo sapiens_hsa040100.50620908
126ABC transporters_Homo sapiens_hsa020100.50459385
127FoxO signaling pathway_Homo sapiens_hsa040680.50346656
128Shigellosis_Homo sapiens_hsa051310.50116547
129Butanoate metabolism_Homo sapiens_hsa006500.49635573
130Glutathione metabolism_Homo sapiens_hsa004800.49461137
131Type II diabetes mellitus_Homo sapiens_hsa049300.49355681
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.48394681
133Biosynthesis of amino acids_Homo sapiens_hsa012300.48025524
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47627900
135Long-term depression_Homo sapiens_hsa047300.47252974
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46892246
137Osteoclast differentiation_Homo sapiens_hsa043800.45798042
138Colorectal cancer_Homo sapiens_hsa052100.45291419
139Toxoplasmosis_Homo sapiens_hsa051450.44688968
140Hippo signaling pathway_Homo sapiens_hsa043900.44612818
141Ras signaling pathway_Homo sapiens_hsa040140.43737678
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43435325
143Protein digestion and absorption_Homo sapiens_hsa049740.41259792
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41211891
145Estrogen signaling pathway_Homo sapiens_hsa049150.39765927

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