ANKRD22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1defense response to fungus (GO:0050832)8.08267284
2leukocyte aggregation (GO:0070486)7.82061808
3detection of bacterium (GO:0016045)7.72137020
4desmosome organization (GO:0002934)7.29039409
5leukocyte migration involved in inflammatory response (GO:0002523)7.25317090
6detection of other organism (GO:0098543)6.85330307
7establishment of skin barrier (GO:0061436)6.73623647
8regulation of water loss via skin (GO:0033561)6.28392737
9killing of cells in other organism involved in symbiotic interaction (GO:0051883)6.08546510
10disruption of cells of other organism involved in symbiotic interaction (GO:0051818)6.08546510
11response to peptidoglycan (GO:0032494)5.56500732
12response to fungus (GO:0009620)5.33535047
13positive regulation of type 2 immune response (GO:0002830)5.24412792
14keratinization (GO:0031424)5.22417187
15antibacterial humoral response (GO:0019731)5.18523823
16production of molecular mediator involved in inflammatory response (GO:0002532)5.16784526
17mucosal immune response (GO:0002385)5.03547106
18hydrogen peroxide biosynthetic process (GO:0050665)5.03344328
19antimicrobial humoral response (GO:0019730)4.97052381
20negative regulation of interleukin-12 production (GO:0032695)4.92978794
21neutrophil activation involved in immune response (GO:0002283)4.86924250
22regulation of T-helper 1 cell differentiation (GO:0045625)4.83836211
23sequestering of metal ion (GO:0051238)4.83685484
24organ or tissue specific immune response (GO:0002251)4.78788576
25regulation of T cell tolerance induction (GO:0002664)4.75331279
26cellular response to type I interferon (GO:0071357)4.68972116
27type I interferon signaling pathway (GO:0060337)4.68972116
28innate immune response in mucosa (GO:0002227)4.67877999
29superoxide anion generation (GO:0042554)4.67805417
30response to type I interferon (GO:0034340)4.64768964
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.61560100
32regulation of dendritic cell antigen processing and presentation (GO:0002604)4.55130780
33interferon-gamma-mediated signaling pathway (GO:0060333)4.54050929
34keratinocyte differentiation (GO:0030216)4.53535877
35immunoglobulin mediated immune response (GO:0016064)4.53283607
36disruption of cells of other organism (GO:0044364)4.50500862
37killing of cells of other organism (GO:0031640)4.50500862
38lipoxygenase pathway (GO:0019372)4.50198987
39positive regulation by organism of defense response of other organism involved in symbiotic interact4.43746700
40modulation by symbiont of host immune response (GO:0052553)4.43746700
41positive regulation by symbiont of host defense response (GO:0052509)4.43746700
42modulation by symbiont of host defense response (GO:0052031)4.43746700
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43746700
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43746700
45positive regulation of cAMP-mediated signaling (GO:0043950)4.43219432
46reactive oxygen species biosynthetic process (GO:1903409)4.42368297
47neutrophil mediated immunity (GO:0002446)4.40224076
48interferon-gamma secretion (GO:0072643)4.36837690
49neutrophil activation (GO:0042119)4.36478481
50T-helper 1 type immune response (GO:0042088)4.30162393
51respiratory burst (GO:0045730)4.28243113
52regulation of tolerance induction (GO:0002643)4.23910115
53multicellular organismal water homeostasis (GO:0050891)4.18603959
54cellular extravasation (GO:0045123)4.16596222
55macrophage activation involved in immune response (GO:0002281)4.14388212
56primary alcohol catabolic process (GO:0034310)4.13416004
57granulocyte activation (GO:0036230)4.10680066
58chronic inflammatory response (GO:0002544)4.01258545
59myeloid leukocyte mediated immunity (GO:0002444)4.01256974
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00423197
61positive regulation of antigen processing and presentation (GO:0002579)3.98856735
62positive regulation of gamma-delta T cell activation (GO:0046645)3.94307459
63hemidesmosome assembly (GO:0031581)3.91488587
64sphingoid metabolic process (GO:0046519)3.90531575
65positive regulation of vesicle fusion (GO:0031340)3.89162275
66detection of molecule of bacterial origin (GO:0032490)3.87217330
67regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.87025223
68regulation of antigen processing and presentation (GO:0002577)3.82029224
69kynurenine metabolic process (GO:0070189)3.80572374
70positive regulation of tolerance induction (GO:0002645)3.79505582
71leukotriene metabolic process (GO:0006691)3.74851271
72antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74528550
73positive regulation of interleukin-1 beta secretion (GO:0050718)3.74512728
74positive regulation of mast cell activation (GO:0033005)3.74173444
75phagosome maturation (GO:0090382)3.73004074
76regulation of interferon-alpha production (GO:0032647)3.71845852
77regulation of chronic inflammatory response (GO:0002676)3.70576090
78defense response to Gram-positive bacterium (GO:0050830)3.69755901
79regulation of interferon-beta biosynthetic process (GO:0045357)3.68878787
80water homeostasis (GO:0030104)3.67361630
81lymphocyte chemotaxis (GO:0048247)3.66816994
82indole-containing compound catabolic process (GO:0042436)3.65953088
83indolalkylamine catabolic process (GO:0046218)3.65953088
84tryptophan catabolic process (GO:0006569)3.65953088
85neutrophil chemotaxis (GO:0030593)3.65468101
86antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65239337
87protein localization to kinetochore (GO:0034501)3.63510185
88positive regulation of T-helper cell differentiation (GO:0045624)3.61757120
89cellular response to interferon-gamma (GO:0071346)3.61028253
90T cell migration (GO:0072678)3.60519974
91regulation of interleukin-1 beta secretion (GO:0050706)3.59308726
92response to interferon-gamma (GO:0034341)3.58663231
93attachment of spindle microtubules to kinetochore (GO:0008608)3.58508665
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.57989101
95negative regulation of cell killing (GO:0031342)3.57989101
96regulation of interleukin-12 production (GO:0032655)3.57874533
97positive regulation of interferon-alpha production (GO:0032727)3.57321549
98positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.57276786
99regulation of type 2 immune response (GO:0002828)3.56691234
100B cell mediated immunity (GO:0019724)3.56355128
101regulation of natural killer cell differentiation (GO:0032823)3.56230887
102molting cycle (GO:0042303)3.55543007
103hair cycle (GO:0042633)3.55543007
104neutrophil migration (GO:1990266)3.54679814
105detection of external biotic stimulus (GO:0098581)3.52974279
106positive regulation of interleukin-1 secretion (GO:0050716)3.52044108
107lipopolysaccharide-mediated signaling pathway (GO:0031663)3.51821657
108positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.50069950
109eosinophil chemotaxis (GO:0048245)3.49531587
110antigen processing and presentation of endogenous antigen (GO:0019883)3.49320028
111defense response to protozoan (GO:0042832)3.49299664
112positive regulation of interleukin-12 production (GO:0032735)3.48054994
113leukotriene biosynthetic process (GO:0019370)3.46120757
114positive regulation of toll-like receptor signaling pathway (GO:0034123)3.45872966
115epidermal cell differentiation (GO:0009913)3.45686489
116regulation of mast cell activation (GO:0033003)3.45495771
117regulation of mononuclear cell migration (GO:0071675)3.42128148
118response to interferon-beta (GO:0035456)3.40660726
119ethanol metabolic process (GO:0006067)3.37729563
120sphingosine metabolic process (GO:0006670)3.37230820
121regulation of T-helper cell differentiation (GO:0045622)3.35890417
122microglial cell activation (GO:0001774)3.33609076
123regulation of hypersensitivity (GO:0002883)3.32033496
124protein localization to chromosome, centromeric region (GO:0071459)3.29555250
125regulation of interleukin-8 secretion (GO:2000482)3.28818496
126regulation of chemokine secretion (GO:0090196)3.28339753
127regulation of myeloid leukocyte mediated immunity (GO:0002886)3.27641034
128positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27557937
129keratinocyte proliferation (GO:0043616)3.25522216
130NADPH regeneration (GO:0006740)3.24730190
131pentose-phosphate shunt (GO:0006098)3.24680288
132regulation of ruffle assembly (GO:1900027)3.24613610
133regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.23213426
134negative regulation of stress fiber assembly (GO:0051497)3.21684482
135prostanoid biosynthetic process (GO:0046457)3.20880936
136prostaglandin biosynthetic process (GO:0001516)3.20880936
137detection of biotic stimulus (GO:0009595)3.19976456
138antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18958409
139negative regulation of interleukin-10 production (GO:0032693)3.18702299
140negative regulation of viral genome replication (GO:0045071)3.17562704
141regulation of interleukin-10 production (GO:0032653)3.17405377
142regulation of interleukin-1 secretion (GO:0050704)3.17371064
143response to protozoan (GO:0001562)3.16568367
144positive regulation of T-helper 1 type immune response (GO:0002827)3.16216446
145positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.14587693
146positive regulation of interleukin-1 beta production (GO:0032731)3.13848336
147positive regulation of osteoblast proliferation (GO:0033690)3.13320860
148bundle of His cell to Purkinje myocyte communication (GO:0086069)3.13097558
149arachidonic acid secretion (GO:0050482)3.12902940
150icosanoid secretion (GO:0032309)3.12902940
151eosinophil migration (GO:0072677)3.12757177
152negative regulation of keratinocyte proliferation (GO:0010839)3.10567599
153positive regulation of mast cell activation involved in immune response (GO:0033008)3.09681016
154positive regulation of mast cell degranulation (GO:0043306)3.09681016
155positive regulation of interleukin-10 production (GO:0032733)3.08809457
156positive regulation of interferon-beta production (GO:0032728)3.07701435
157keratinocyte development (GO:0003334)3.07519751
158peptide cross-linking (GO:0018149)3.05718987
159positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.05332491
160fatty acid derivative biosynthetic process (GO:1901570)3.05136235
161icosanoid biosynthetic process (GO:0046456)3.05136235
162regulation of mast cell degranulation (GO:0043304)3.04419284
163positive regulation of interleukin-1 production (GO:0032732)3.03405709
164ectoderm development (GO:0007398)3.02960006
165tryptophan metabolic process (GO:0006568)3.00954346
166regulation of mast cell activation involved in immune response (GO:0033006)3.00928067
167regulation of inflammatory response to antigenic stimulus (GO:0002861)3.00225173
168pentose metabolic process (GO:0019321)2.99914839
169regulation of T-helper 1 type immune response (GO:0002825)2.99787973
170diol metabolic process (GO:0034311)2.98748629
171granulocyte chemotaxis (GO:0071621)2.98147457
172myeloid dendritic cell differentiation (GO:0043011)2.97962491
173dendritic cell chemotaxis (GO:0002407)2.97954400
174regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97745818
175regulation of leukocyte degranulation (GO:0043300)2.97535807
176defense response to virus (GO:0051607)2.96945396
177positive regulation of defense response to virus by host (GO:0002230)2.96891606
178negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.95582156
179granulocyte migration (GO:0097530)2.95167991
180cellular response to interferon-beta (GO:0035458)2.93063359
181regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.92406127
182regulation of regulatory T cell differentiation (GO:0045589)2.92095646
183regulation of T-helper 2 cell differentiation (GO:0045628)2.90712913
184phosphatidylinositol acyl-chain remodeling (GO:0036149)2.90524247
185response to host immune response (GO:0052572)2.90251578
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90251578
187negative regulation of interferon-gamma production (GO:0032689)2.88118748
188defense response to bacterium (GO:0042742)2.86335519
189regulation of regulated secretory pathway (GO:1903305)2.85924407
190positive regulation of regulated secretory pathway (GO:1903307)2.85876283

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.83064220
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.97979750
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.91027249
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.15974451
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.00740939
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.93468852
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12573698
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74637999
9* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.64845879
10* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.51472218
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.21575406
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14763805
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.12485397
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.07614872
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.07406039
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06085690
17GATA1_22025678_ChIP-Seq_K562_Human2.02355016
18TP63_17297297_ChIP-ChIP_HaCaT_Human11.2549370
19SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98777251
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98777251
21BRD4_27068464_Chip-Seq_AML-cells_Mouse1.98041179
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.97243711
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96579081
24SOX9_24532713_ChIP-Seq_HFSC_Mouse1.96164889
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.86848717
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.85655730
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.84333575
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83070738
29RUNX_20019798_ChIP-Seq_JUKART_Human1.78798814
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71701353
31SCL_19346495_ChIP-Seq_HPC-7_Human1.69429878
32SPI1_23127762_ChIP-Seq_K562_Human1.67750615
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.65208647
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63778929
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61198916
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60722908
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54883738
38AR_21909140_ChIP-Seq_LNCAP_Human1.54729435
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54525073
40EGR1_19032775_ChIP-ChIP_M12_Human1.54314735
41* SOX2_20726797_ChIP-Seq_SW620_Human1.48624227
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46929811
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46769291
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.46386854
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44386109
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.43760537
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.41554369
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.38056018
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36959116
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36123445
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35950552
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34855578
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.33524010
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.33419662
55* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.32963209
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31982710
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30611009
58ATF3_27146783_Chip-Seq_COLON_Human1.30607688
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29845975
60KLF5_25053715_ChIP-Seq_YYC3_Human1.29507557
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29060305
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.26150282
63GATA4_25053715_ChIP-Seq_YYC3_Human1.26093220
64RACK7_27058665_Chip-Seq_MCF-7_Human1.24406673
65MYB_26560356_Chip-Seq_TH1_Human1.23231928
66RXR_22108803_ChIP-Seq_LS180_Human1.22274193
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22087710
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21357205
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.20046056
70* TP63_23658742_ChIP-Seq_EP156T_Human1.19631030
71STAT1_20625510_ChIP-Seq_HELA_Human1.19601826
72GATA3_27048872_Chip-Seq_THYMUS_Human1.19576183
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17673999
74* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14080901
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12870378
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12525639
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11938630
78* SPI1_23547873_ChIP-Seq_NB4_Human1.11432203
79RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09843291
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09735508
81MYB_26560356_Chip-Seq_TH2_Human1.09519952
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05206179
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04897940
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03549805
85CJUN_26792858_Chip-Seq_BT549_Human1.03237111
86ZNF263_19887448_ChIP-Seq_K562_Human1.02872534
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02088619
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01833179
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01662079
90GATA1_19941827_ChIP-Seq_MEL_Mouse1.01563398
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00184398
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99659181
93* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99175721
94VDR_24763502_ChIP-Seq_THP-1_Human0.95012871
95GATA3_24758297_ChIP-Seq_MCF-7_Human0.94199596
96MAF_26560356_Chip-Seq_TH1_Human0.91906867
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91461856
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90978796
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90432698
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90203916
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89713692
102GATA6_25053715_ChIP-Seq_YYC3_Human0.89568342
103PU_27001747_Chip-Seq_BMDM_Mouse0.89259624
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87802231
105TCF7_22412390_ChIP-Seq_EML_Mouse0.87469020
106BCOR_27268052_Chip-Seq_Bcells_Human0.86213750
107RUNX1_22412390_ChIP-Seq_EML_Mouse0.85899411
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84241521
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81581880
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80988164
111SMRT_27268052_Chip-Seq_Bcells_Human0.80983746
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80786142
113FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80632959
114UTX_26944678_Chip-Seq_JUKART_Human0.80475028
115PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.80460544
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79029431
117* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79024358
118GATA1_19941826_ChIP-Seq_K562_Human0.79011048
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78819779
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78723795
121VDR_21846776_ChIP-Seq_THP-1_Human0.77573471
122GATA3_26560356_Chip-Seq_TH2_Human0.77072772
123* TP63_22573176_ChIP-Seq_HFKS_Human0.76657530
124BCL6_27268052_Chip-Seq_Bcells_Human0.76011821
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75848441
126VDR_24787735_ChIP-Seq_THP-1_Human0.75069645
127PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74733241
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73818389
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72514939
130LXR_22158963_ChIP-Seq_LIVER_Mouse0.72409787
131GATA6_21074721_ChIP-Seq_CACO-2_Human0.71979051
132NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71697616
133NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71697616
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70559479
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69473585
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69128078
137GATA2_19941826_ChIP-Seq_K562_Human0.68614021
138TCF3_18692474_ChIP-Seq_MESCs_Mouse0.68604342
139* CEBPB_22108803_ChIP-Seq_LS180_Human0.68436820
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.68065581
141GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.67811086
142RXR_22158963_ChIP-Seq_LIVER_Mouse0.67594130
143FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.66828064
144RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.64058488
145TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.64052374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier5.20585490
2MP0010234_abnormal_vibrissa_follicle4.21791194
3MP0001835_abnormal_antigen_presentation4.17596244
4MP0006082_CNS_inflammation3.57265444
5MP0003436_decreased_susceptibility_to3.37750563
6MP0003941_abnormal_skin_development3.18303058
7MP0005451_abnormal_body_composition3.09770964
8MP0003453_abnormal_keratinocyte_physiol3.06902833
9MP0005671_abnormal_response_to3.04493913
10MP0005501_abnormal_skin_physiology3.02084557
11MP0004381_abnormal_hair_follicle2.95972776
12MP0002060_abnormal_skin_morphology2.92631927
13MP0001216_abnormal_epidermal_layer2.85526791
14MP0000579_abnormal_nail_morphology2.66257065
15MP0002277_abnormal_respiratory_mucosa2.62151500
16MP0001851_eye_inflammation2.59549601
17MP0009278_abnormal_bone_marrow2.50853889
18MP0003303_peritoneal_inflammation2.39698173
19MP0004947_skin_inflammation2.24328577
20MP0002254_reproductive_system_inflammat2.22330267
21MP0005275_abnormal_skin_tensile2.20521134
22MP0002098_abnormal_vibrissa_morphology2.14375431
23MP0010678_abnormal_skin_adnexa2.13074139
24MP0009785_altered_susceptibility_to2.12856860
25MP0003566_abnormal_cell_adhesion2.12004159
26MP0010771_integument_phenotype2.10925802
27MP0008789_abnormal_olfactory_epithelium2.08064109
28MP0000383_abnormal_hair_follicle2.04665883
29MP0005499_abnormal_olfactory_system2.01447187
30MP0005394_taste/olfaction_phenotype2.01447187
31MP0002009_preneoplasia1.98977163
32MP0000647_abnormal_sebaceous_gland1.92423623
33MP0004510_myositis1.89564307
34MP0005310_abnormal_salivary_gland1.80822982
35MP0003693_abnormal_embryo_hatching1.74393633
36MP0000377_abnormal_hair_follicle1.69061366
37MP0008469_abnormal_protein_level1.68762810
38MP0005023_abnormal_wound_healing1.65646031
39MP0001533_abnormal_skeleton_physiology1.63475194
40MP0002419_abnormal_innate_immunity1.61724078
41MP0000467_abnormal_esophagus_morphology1.60706750
42MP0003183_abnormal_peptide_metabolism1.60382902
43MP0000465_gastrointestinal_hemorrhage1.57699584
44MP0001984_abnormal_olfaction1.56646317
45MP0001545_abnormal_hematopoietic_system1.54672415
46MP0005397_hematopoietic_system_phenotyp1.54672415
47MP0003172_abnormal_lysosome_physiology1.54220046
48MP0002877_abnormal_melanocyte_morpholog1.53696766
49MP0003646_muscle_fatigue1.51300895
50MP0002132_abnormal_respiratory_system1.49586337
51MP0000716_abnormal_immune_system1.48316208
52MP0003724_increased_susceptibility_to1.48043411
53MP0009840_abnormal_foam_cell1.44389576
54MP0009931_abnormal_skin_appearance1.42931013
55MP0005058_abnormal_lysosome_morphology1.39821147
56MP0009333_abnormal_splenocyte_physiolog1.39624204
57MP0001849_ear_inflammation1.37379331
58MP0001191_abnormal_skin_condition1.37063704
59MP0000427_abnormal_hair_cycle1.36402428
60MP0001346_abnormal_lacrimal_gland1.35740678
61MP0003195_calcinosis1.28109450
62MP0005076_abnormal_cell_differentiation1.26223993
63MP0000604_amyloidosis1.25811257
64MP0000858_altered_metastatic_potential1.25071862
65MP0009053_abnormal_anal_canal1.23381205
66MP0002139_abnormal_hepatobiliary_system1.22310801
67MP0005025_abnormal_response_to1.20701770
68MP0002138_abnormal_hepatobiliary_system1.19734763
69MP0000566_synostosis1.19733350
70MP0002398_abnormal_bone_marrow1.18190268
71MP0002405_respiratory_system_inflammati1.17508413
72MP0003075_altered_response_to1.16841864
73MP0003191_abnormal_cellular_cholesterol1.15084783
74MP0005164_abnormal_response_to1.12692033
75MP0005166_decreased_susceptibility_to1.09886012
76MP0002429_abnormal_blood_cell1.09082015
77MP0000569_abnormal_digit_pigmentation1.09016472
78MP0001881_abnormal_mammary_gland1.08879607
79MP0004264_abnormal_extraembryonic_tissu1.06967019
80MP0002148_abnormal_hypersensitivity_rea1.06493209
81MP0004782_abnormal_surfactant_physiolog1.05014197
82MP0003806_abnormal_nucleotide_metabolis1.02761293
83MP0000762_abnormal_tongue_morphology1.02630306
84MP0005000_abnormal_immune_tolerance1.02174422
85MP0010352_gastrointestinal_tract_polyps1.02033497
86MP0003763_abnormal_thymus_physiology1.01863560
87MP0000343_altered_response_to1.01316203
88MP0005167_abnormal_blood-brain_barrier0.99956119
89MP0001873_stomach_inflammation0.98492565
90MP0009765_abnormal_xenobiotic_induced0.98340104
91MP0009763_increased_sensitivity_to0.97953582
92MP0002998_abnormal_bone_remodeling0.96339152
93MP0003136_yellow_coat_color0.95239102
94MP0000689_abnormal_spleen_morphology0.94310159
95MP0001663_abnormal_digestive_system0.94209903
96MP0002332_abnormal_exercise_endurance0.93978920
97MP0005390_skeleton_phenotype0.93172467
98MP0008260_abnormal_autophagy0.92603110
99MP0003828_pulmonary_edema0.92037284
100MP0009764_decreased_sensitivity_to0.90636656
101MP0002837_dystrophic_cardiac_calcinosis0.90533274
102MP0002722_abnormal_immune_system0.88937315
103MP0003448_altered_tumor_morphology0.87127041
104MP0004185_abnormal_adipocyte_glucose0.85130091
105MP0003866_abnormal_defecation0.85014777
106MP0000367_abnormal_coat/_hair0.84929589
107MP0001845_abnormal_inflammatory_respons0.84274743
108MP0000627_abnormal_mammary_gland0.84227548
109MP0002420_abnormal_adaptive_immunity0.83257945
110MP0001819_abnormal_immune_cell0.82556159
111MP0003300_gastrointestinal_ulcer0.81932112
112MP0005377_hearing/vestibular/ear_phenot0.81629735
113MP0003878_abnormal_ear_physiology0.81629735
114MP0004883_abnormal_blood_vessel0.80122628
115MP0002006_tumorigenesis0.79951772
116MP0010155_abnormal_intestine_physiology0.79614907
117MP0003690_abnormal_glial_cell0.78442015
118MP0003656_abnormal_erythrocyte_physiolo0.77848340
119MP0001243_abnormal_dermal_layer0.77583459
120MP0002452_abnormal_antigen_presenting0.76910026
121MP0006054_spinal_hemorrhage0.76749397
122MP0002693_abnormal_pancreas_physiology0.74784624
123MP0001800_abnormal_humoral_immune0.73525816
124MP0001853_heart_inflammation0.72597644
125MP0000015_abnormal_ear_pigmentation0.71310687
126MP0000685_abnormal_immune_system0.70506881
127MP0008874_decreased_physiological_sensi0.67434373
128MP0005408_hypopigmentation0.66878104
129MP0004043_abnormal_pH_regulation0.64727913
130MP0005464_abnormal_platelet_physiology0.64271343
131MP0002166_altered_tumor_susceptibility0.64129319
132MP0000371_diluted_coat_color0.63292511
133MP0000920_abnormal_myelination0.63149643
134MP0005319_abnormal_enzyme/_coenzyme0.62911234
135MP0008004_abnormal_stomach_pH0.60921759
136MP0002653_abnormal_ependyma_morphology0.59548490
137MP0002723_abnormal_immune_serum0.59128488
138MP0002136_abnormal_kidney_physiology0.58463532
139MP0005388_respiratory_system_phenotype0.57915148
140MP0002133_abnormal_respiratory_system0.57915148
141MP0002233_abnormal_nose_morphology0.56719572
142MP0005387_immune_system_phenotype0.56540172
143MP0001790_abnormal_immune_system0.56540172
144MP0005381_digestive/alimentary_phenotyp0.53992412
145MP0005174_abnormal_tail_pigmentation0.53887385

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.73091411
2Recurrent abscess formation (HP:0002722)6.24073682
3Recurrent bacterial skin infections (HP:0005406)5.82619393
4Congenital ichthyosiform erythroderma (HP:0007431)5.64692234
5Recurrent gram-negative bacterial infections (HP:0005420)5.53811895
6Optic neuritis (HP:0100653)5.38412729
7Retrobulbar optic neuritis (HP:0100654)5.38412729
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.27968396
9Lip pit (HP:0100267)4.99457408
10Hypotrichosis (HP:0001006)4.86895472
11Chronic obstructive pulmonary disease (HP:0006510)4.41262133
12Obstructive lung disease (HP:0006536)4.41262133
13Gastrointestinal infarctions (HP:0005244)4.39909252
14Increased IgE level (HP:0003212)4.35120782
15Right ventricular cardiomyopathy (HP:0011663)4.13018391
16Onycholysis (HP:0001806)4.06485447
17Ectropion (HP:0000656)4.03284971
18Systemic lupus erythematosus (HP:0002725)3.99554691
19Abnormality of glycolipid metabolism (HP:0010969)3.92625212
20Abnormality of liposaccharide metabolism (HP:0010968)3.92625212
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.92625212
22Urticaria (HP:0001025)3.84474095
23Gingivitis (HP:0000230)3.79352348
24Plantar hyperkeratosis (HP:0007556)3.69488932
25Keratoconjunctivitis (HP:0001096)3.67940113
26Parakeratosis (HP:0001036)3.67652904
27Hemoptysis (HP:0002105)3.67245301
28Elevated erythrocyte sedimentation rate (HP:0003565)3.66978588
29Stomatitis (HP:0010280)3.58095793
30Mediastinal lymphadenopathy (HP:0100721)3.55596728
31Pulmonary infiltrates (HP:0002113)3.51410313
32Woolly hair (HP:0002224)3.49268288
33Abnormality of macrophages (HP:0004311)3.49052600
34Abnormality of nail color (HP:0100643)3.45146370
35Vasculitis (HP:0002633)3.44959327
36Increased IgM level (HP:0003496)3.25650262
37Chronic otitis media (HP:0000389)3.25287444
38Palmoplantar hyperkeratosis (HP:0000972)3.23600862
39Alopecia of scalp (HP:0002293)3.22251125
40Recurrent cutaneous fungal infections (HP:0011370)3.16581150
41Chronic mucocutaneous candidiasis (HP:0002728)3.16581150
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.13687544
43Curly hair (HP:0002212)3.08718215
44Papilledema (HP:0001085)3.08407701
45Autoimmune hemolytic anemia (HP:0001890)3.04110665
46Fragile nails (HP:0001808)3.04024592
47Sparse eyelashes (HP:0000653)3.03429550
48Palmar hyperkeratosis (HP:0010765)3.00263783
49Pili torti (HP:0003777)2.99926124
50Milia (HP:0001056)2.99055299
51Popliteal pterygium (HP:0009756)2.98061930
52Erythema (HP:0010783)2.93125420
53Premature loss of primary teeth (HP:0006323)2.90042068
54Corneal erosion (HP:0200020)2.89790518
55Erythroderma (HP:0001019)2.85839982
56Hypergammaglobulinemia (HP:0010702)2.84592388
57Cellulitis (HP:0100658)2.84057434
58Encephalitis (HP:0002383)2.83105249
59Autoimmune thrombocytopenia (HP:0001973)2.82302455
60Hypohidrosis (HP:0000966)2.80546464
61Pustule (HP:0200039)2.80283176
62Stenosis of the external auditory canal (HP:0000402)2.80166217
63Malnutrition (HP:0004395)2.79855952
64Arterial thrombosis (HP:0004420)2.79230500
65Nail dystrophy (HP:0008404)2.79119869
66Thick nail (HP:0001805)2.77941966
67Ventricular tachycardia (HP:0004756)2.76031515
68Gangrene (HP:0100758)2.72681515
69Hypoplastic labia majora (HP:0000059)2.69469358
70Recurrent viral infections (HP:0004429)2.67933668
71Anorexia (HP:0002039)2.62319280
72Increased cerebral lipofuscin (HP:0011813)2.61997403
73Abnormal hemoglobin (HP:0011902)2.61299259
74Loss of speech (HP:0002371)2.61168694
75Sepsis (HP:0100806)2.58747657
76Chest pain (HP:0100749)2.54562887
77Abnormality of T cell number (HP:0011839)2.54061484
78Recurrent skin infections (HP:0001581)2.53452947
79Myositis (HP:0100614)2.53319361
80Oligodontia (HP:0000677)2.51681604
81Stomach cancer (HP:0012126)2.51249559
82Spontaneous hematomas (HP:0007420)2.48158616
83Abnormality of the labia majora (HP:0012881)2.47879893
84Skin ulcer (HP:0200042)2.46249498
85Glomerulonephritis (HP:0000099)2.45925298
86Blepharitis (HP:0000498)2.44874622
87Abnormal blistering of the skin (HP:0008066)2.42468823
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.42172500
89Dysostosis multiplex (HP:0000943)2.42073546
90Leukocytosis (HP:0001974)2.41748294
91Amyloidosis (HP:0011034)2.38682882
92Peritonitis (HP:0002586)2.36829159
93Congenital, generalized hypertrichosis (HP:0004540)2.36703642
94Vacuolated lymphocytes (HP:0001922)2.34839658
95Prostate neoplasm (HP:0100787)2.34790197
96Pruritus (HP:0000989)2.33775795
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.32486850
98Disinhibition (HP:0000734)2.31539435
99Abnormality of the pleura (HP:0002103)2.31089180
100Recurrent bronchitis (HP:0002837)2.30863136
101Pulmonary embolism (HP:0002204)2.29535360
102Absent eyebrow (HP:0002223)2.26510479
103T lymphocytopenia (HP:0005403)2.26449352
104Abnormality of the prostate (HP:0008775)2.25288079
105Cheilitis (HP:0100825)2.24465571
106Recurrent fungal infections (HP:0002841)2.16355032
107Abnormality of the endocardium (HP:0004306)2.15350344
108Abnormality of the axillary hair (HP:0100134)2.13728315
109Abnormality of secondary sexual hair (HP:0009888)2.13728315
110Vertigo (HP:0002321)2.10717837
111Keratitis (HP:0000491)2.07621026
112Acanthosis nigricans (HP:0000956)2.07543407
113Polyneuropathy (HP:0001271)2.06210317
114Joint swelling (HP:0001386)2.04971286
115Abnormality of the distal phalanges of the toes (HP:0010182)2.04706405
116Nasal polyposis (HP:0100582)2.02955308
117Asymmetry of the thorax (HP:0001555)2.02431875
118Male infertility (HP:0003251)2.02120978
119Episodic fever (HP:0001954)2.02013129
120Abnormality of B cell number (HP:0010975)2.01960282
121Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.01075757
122Abnormality of the pericardium (HP:0001697)2.00585429
123Increased serum ferritin (HP:0003281)1.99473494
124Orchitis (HP:0100796)1.98982730
125Abnormality of the nasal mucosa (HP:0000433)1.98526675
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95699395
127Alveolar cell carcinoma (HP:0006519)1.95577822
128Eosinophilia (HP:0001880)1.94436651
129Meningitis (HP:0001287)1.93619629
130Skin rash (HP:0000988)1.93597633
131Albinism (HP:0001022)1.93202383
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92894089
133Abnormality of polysaccharide metabolism (HP:0011012)1.92894089
134Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92894089
135Gingival bleeding (HP:0000225)1.92596875
136Skin pits (HP:0100276)1.89894064
137Areflexia of lower limbs (HP:0002522)1.83757348
138Labial hypoplasia (HP:0000066)1.83610123
139Palmoplantar keratoderma (HP:0000982)1.82625592
140Sparse scalp hair (HP:0002209)1.79590902
141Type I diabetes mellitus (HP:0100651)1.77871821
142Ridged nail (HP:0001807)1.77854565
143Periodontitis (HP:0000704)1.77630365
144Dry skin (HP:0000958)1.74739937
145Anhidrosis (HP:0000970)1.74333502
146Hypoplastic female external genitalia (HP:0012815)1.74199498
147Reticulocytopenia (HP:0001896)1.71504119
148Pyloric stenosis (HP:0002021)1.71164139
149Hematochezia (HP:0002573)1.70565894
150Periauricular skin pits (HP:0100277)1.69222702
151Preauricular pit (HP:0004467)1.69222702
152Recurrent pneumonia (HP:0006532)1.64904319
153Abnormality of the labia (HP:0000058)1.64292146
154Dehydration (HP:0001944)1.63387540
155Natal tooth (HP:0000695)1.62146502
156Hypoparathyroidism (HP:0000829)1.61013744
157Concave nail (HP:0001598)1.59411198
158Abnormal foot bone ossification (HP:0010675)1.58400695
159Hypermelanotic macule (HP:0001034)1.56750094
160Distal lower limb muscle weakness (HP:0009053)1.53291073
161Keratoconjunctivitis sicca (HP:0001097)1.51730849
162Abnormality of the gastric mucosa (HP:0004295)1.51530984
163Metaphyseal irregularity (HP:0003025)1.51138134
164Abnormal hair laboratory examination (HP:0003328)1.50812964
165Xerostomia (HP:0000217)1.48198248
166Follicular hyperkeratosis (HP:0007502)1.47738479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.55109674
2RIPK43.81293956
3TRPM73.76340359
4IRAK43.37313933
5ERBB33.28826666
6JAK33.09187851
7STK103.03270343
8GRK72.88791964
9IRAK32.80718340
10MATK2.65559332
11BLK2.61087595
12JAK12.52549776
13MST42.52419514
14MAP4K12.42593906
15ERN12.41358408
16MAPKAPK32.28878978
17TBK12.16358029
18IKBKB2.03780974
19ADRBK22.02582036
20RIPK11.99444325
21MAP3K21.99124539
22TAOK11.98461430
23MAP3K121.98380040
24KIT1.98036675
25FGR1.96681595
26CSK1.93034371
27MAP3K91.93027856
28RPS6KB21.87586587
29FGFR41.84341720
30EPHB11.81291102
31MAP2K31.78338519
32CLK11.73933424
33TEC1.71930170
34MST1R1.69817690
35TAOK31.66409101
36IRAK11.62352087
37TESK11.61476273
38LRRK21.57672221
39FRK1.51304982
40STK41.48884147
41LYN1.45665025
42LATS11.40481894
43BTK1.39063872
44RPS6KA41.37643083
45FER1.36115277
46NEK11.35405673
47ACVR1B1.32245198
48PTK21.31692402
49EPHA21.31169209
50NEK21.27493094
51LATS21.22731402
52CDC42BPA1.22070330
53MAP3K131.21353128
54CHUK1.10312427
55DDR21.05750445
56MAP2K61.04474034
57MAP3K110.99441326
58HCK0.98593107
59LCK0.98581726
60STK240.98002513
61ZAP700.94766313
62PBK0.88721526
63MAPKAPK20.88187541
64ITK0.86534000
65BRSK20.86157031
66TTN0.86156073
67CSF1R0.83915965
68PRPF4B0.81735499
69EPHA30.81614875
70AURKB0.80070750
71NLK0.78708940
72MAP3K140.75592773
73DYRK30.74586869
74IRAK20.74050813
75CDK90.72718620
76NME20.63867648
77PIM20.63033176
78STK38L0.61801987
79TGFBR20.61352981
80ABL10.60948563
81MAP3K60.60435776
82STK30.60055345
83MAP3K10.58190485
84MAP3K80.57906905
85AURKA0.57226193
86CDK60.57039973
87TYK20.56863083
88SIK30.56683440
89MARK30.56501106
90LIMK10.55330215
91CDK40.53621358
92PTK60.52849881
93TNK20.52258446
94HIPK20.52007013
95TESK20.51384890
96CDK30.50927573
97MAPK40.50377481
98EIF2AK20.50367152
99STK380.50277330
100PIM10.49908248
101IKBKE0.47341480
102STK110.45666932
103PRKCQ0.43595473
104SGK30.42645904
105ABL20.42548049
106DAPK20.42142523
107FES0.41687051
108OXSR10.41603275
109BUB10.40333699
110GRK10.40208523
111PDK10.38455562
112TAOK20.38428361
113MELK0.37854132
114PIK3CG0.35800969
115MAPK110.34349775
116PDPK10.34180202
117EGFR0.32576436
118MAP3K50.31258626
119IGF1R0.29407035
120TTK0.28930835
121DYRK20.28341409
122GRK60.28222275
123YES10.28213120
124BMPR20.27444112
125PIK3CA0.27182232
126CDK70.26832073
127TXK0.25440974
128SYK0.25410146
129MET0.24967151
130MOS0.23040531
131PRKCI0.22761497
132FGFR10.22658329
133PRKAA20.22434478
134PRKCD0.22398922
135KDR0.22246331
136PDGFRB0.22244271
137KSR20.21684020
138FGFR30.21210791
139FYN0.21201616
140JAK20.20703009
141MAPK70.20200196
142RPS6KA50.19761478
143ERBB20.18875944
144INSR0.18423698

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.62056326
2Asthma_Homo sapiens_hsa053103.15767697
3Autoimmune thyroid disease_Homo sapiens_hsa053203.10936758
4Graft-versus-host disease_Homo sapiens_hsa053323.07092209
5Sulfur metabolism_Homo sapiens_hsa009202.85889652
6Histidine metabolism_Homo sapiens_hsa003402.70732862
7Staphylococcus aureus infection_Homo sapiens_hsa051502.66397108
8Leukocyte transendothelial migration_Homo sapiens_hsa046702.65932559
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.65892851
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.59298847
11Type I diabetes mellitus_Homo sapiens_hsa049402.59122476
12Leishmaniasis_Homo sapiens_hsa051402.48453989
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46300284
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.40426701
15Chemical carcinogenesis_Homo sapiens_hsa052042.19800770
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17049951
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14586268
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.13750280
19African trypanosomiasis_Homo sapiens_hsa051432.03281067
20Retinol metabolism_Homo sapiens_hsa008301.88424638
21Antigen processing and presentation_Homo sapiens_hsa046121.88250919
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85526411
23Arachidonic acid metabolism_Homo sapiens_hsa005901.79805055
24Caffeine metabolism_Homo sapiens_hsa002321.78736165
25Measles_Homo sapiens_hsa051621.70303115
26Adherens junction_Homo sapiens_hsa045201.67386474
27Glutathione metabolism_Homo sapiens_hsa004801.67017558
28Pentose phosphate pathway_Homo sapiens_hsa000301.66186748
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64029161
30Sphingolipid metabolism_Homo sapiens_hsa006001.62122921
31Viral myocarditis_Homo sapiens_hsa054161.61295307
32Phenylalanine metabolism_Homo sapiens_hsa003601.60609088
33Bladder cancer_Homo sapiens_hsa052191.57549578
34Herpes simplex infection_Homo sapiens_hsa051681.49618997
35p53 signaling pathway_Homo sapiens_hsa041151.48135142
36Sulfur relay system_Homo sapiens_hsa041221.47086054
37Lysosome_Homo sapiens_hsa041421.38623737
38Primary immunodeficiency_Homo sapiens_hsa053401.32116291
39Osteoclast differentiation_Homo sapiens_hsa043801.26500883
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25668105
41Shigellosis_Homo sapiens_hsa051311.21673737
42Linoleic acid metabolism_Homo sapiens_hsa005911.21439403
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09677184
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08910177
45Other glycan degradation_Homo sapiens_hsa005111.07889005
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07606603
47VEGF signaling pathway_Homo sapiens_hsa043701.07545250
48TNF signaling pathway_Homo sapiens_hsa046681.04746093
49Tuberculosis_Homo sapiens_hsa051521.04425865
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04071485
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02865845
52Pertussis_Homo sapiens_hsa051331.00540516
53Chemokine signaling pathway_Homo sapiens_hsa040621.00376685
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.98699891
55Pancreatic cancer_Homo sapiens_hsa052120.98650233
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97724430
57Tight junction_Homo sapiens_hsa045300.97370954
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96828572
59MicroRNAs in cancer_Homo sapiens_hsa052060.95722421
60Starch and sucrose metabolism_Homo sapiens_hsa005000.94775543
61Amoebiasis_Homo sapiens_hsa051460.94096888
62Toxoplasmosis_Homo sapiens_hsa051450.93197035
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.92405178
64Platelet activation_Homo sapiens_hsa046110.90348069
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.90297717
66Phagosome_Homo sapiens_hsa041450.89775455
67Hepatitis C_Homo sapiens_hsa051600.89507259
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85361473
69Notch signaling pathway_Homo sapiens_hsa043300.85020340
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.83604890
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82758858
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82083983
73beta-Alanine metabolism_Homo sapiens_hsa004100.80421498
74Insulin resistance_Homo sapiens_hsa049310.79644946
75Cell cycle_Homo sapiens_hsa041100.77789174
76Salmonella infection_Homo sapiens_hsa051320.77482425
77Tryptophan metabolism_Homo sapiens_hsa003800.76140052
78FoxO signaling pathway_Homo sapiens_hsa040680.75758140
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73506578
80ABC transporters_Homo sapiens_hsa020100.73392614
81T cell receptor signaling pathway_Homo sapiens_hsa046600.71416742
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.70878553
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70461221
84Mineral absorption_Homo sapiens_hsa049780.68983653
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68836410
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68229318
87Circadian rhythm_Homo sapiens_hsa047100.67276087
88Ether lipid metabolism_Homo sapiens_hsa005650.66501287
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63653076
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.63579093
91Hepatitis B_Homo sapiens_hsa051610.62776705
92Hematopoietic cell lineage_Homo sapiens_hsa046400.59189215
93Acute myeloid leukemia_Homo sapiens_hsa052210.59114436
94Rheumatoid arthritis_Homo sapiens_hsa053230.58892911
95TGF-beta signaling pathway_Homo sapiens_hsa043500.57152770
96Prolactin signaling pathway_Homo sapiens_hsa049170.57012009
97Collecting duct acid secretion_Homo sapiens_hsa049660.55845247
98Tyrosine metabolism_Homo sapiens_hsa003500.54984930
99Small cell lung cancer_Homo sapiens_hsa052220.54686244
100Rap1 signaling pathway_Homo sapiens_hsa040150.53489983
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53257853
102Hippo signaling pathway_Homo sapiens_hsa043900.53238090
103Epstein-Barr virus infection_Homo sapiens_hsa051690.52546177
104Proteoglycans in cancer_Homo sapiens_hsa052050.52076108
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.50837846
106Ribosome_Homo sapiens_hsa030100.50121524
107Legionellosis_Homo sapiens_hsa051340.49686555
108Prostate cancer_Homo sapiens_hsa052150.48240359
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48032688
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.47486169
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47209801
112B cell receptor signaling pathway_Homo sapiens_hsa046620.46796847
113Influenza A_Homo sapiens_hsa051640.46636709
114Galactose metabolism_Homo sapiens_hsa000520.44788025
115Complement and coagulation cascades_Homo sapiens_hsa046100.44354799
116Chronic myeloid leukemia_Homo sapiens_hsa052200.43782960
117Dorso-ventral axis formation_Homo sapiens_hsa043200.43766370
118Ovarian steroidogenesis_Homo sapiens_hsa049130.43739458
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42549383
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.42125398
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41569678
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41028100
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40985747
124Malaria_Homo sapiens_hsa051440.40634235
125Glycerolipid metabolism_Homo sapiens_hsa005610.39839923
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39039012
127Apoptosis_Homo sapiens_hsa042100.38279270
128Systemic lupus erythematosus_Homo sapiens_hsa053220.38118005
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37717736
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33188647
131Type II diabetes mellitus_Homo sapiens_hsa049300.32253534
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29212312
133HTLV-I infection_Homo sapiens_hsa051660.20744573
134Endocytosis_Homo sapiens_hsa041440.18446074
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17952889
136Prion diseases_Homo sapiens_hsa050200.15826112
137Fatty acid biosynthesis_Homo sapiens_hsa000610.14741409
138PPAR signaling pathway_Homo sapiens_hsa033200.13500474
139HIF-1 signaling pathway_Homo sapiens_hsa040660.12192005
140GnRH signaling pathway_Homo sapiens_hsa049120.12018089
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09767205
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07751681

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