ANKRD20A5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.88291078
2righting reflex (GO:0060013)4.71786226
3cellular ketone body metabolic process (GO:0046950)4.58612996
4auditory receptor cell stereocilium organization (GO:0060088)4.29718380
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.26940672
6ketone body metabolic process (GO:1902224)4.21930803
7detection of light stimulus involved in visual perception (GO:0050908)4.01593455
8detection of light stimulus involved in sensory perception (GO:0050962)4.01593455
9tryptophan catabolic process (GO:0006569)4.00284334
10indole-containing compound catabolic process (GO:0042436)4.00284334
11indolalkylamine catabolic process (GO:0046218)4.00284334
12reflex (GO:0060004)3.99636171
13startle response (GO:0001964)3.86289752
14indolalkylamine metabolic process (GO:0006586)3.76360701
15cilium or flagellum-dependent cell motility (GO:0001539)3.71447310
16synapsis (GO:0007129)3.68804440
17photoreceptor cell maintenance (GO:0045494)3.68291102
18multicellular organism reproduction (GO:0032504)3.68290787
19sperm motility (GO:0030317)3.57355704
20regulation of meiosis I (GO:0060631)3.57101459
21epithelial cilium movement (GO:0003351)3.56037285
22male meiosis (GO:0007140)3.53831364
23establishment of protein localization to Golgi (GO:0072600)3.53054757
24monoubiquitinated protein deubiquitination (GO:0035520)3.45812373
25regulation of hippo signaling (GO:0035330)3.35833547
26piRNA metabolic process (GO:0034587)3.29257747
27behavioral response to nicotine (GO:0035095)3.25107540
28tryptophan metabolic process (GO:0006568)3.22423195
29DNA methylation involved in gamete generation (GO:0043046)3.21397550
30protein K11-linked deubiquitination (GO:0035871)3.21363133
31acrosome reaction (GO:0007340)3.21322276
32L-fucose catabolic process (GO:0042355)3.16592113
33fucose catabolic process (GO:0019317)3.16592113
34L-fucose metabolic process (GO:0042354)3.16592113
35detection of mechanical stimulus involved in sensory perception (GO:0050974)3.15765398
36primary amino compound metabolic process (GO:1901160)3.15221321
37TOR signaling (GO:0031929)3.13476659
38serotonin metabolic process (GO:0042428)3.12577479
39negative regulation of sodium ion transport (GO:0010766)3.11427654
40cellular response to sterol (GO:0036315)3.11340628
41DNA double-strand break processing (GO:0000729)3.10465551
42negative regulation of systemic arterial blood pressure (GO:0003085)3.10030069
43regulation of acrosome reaction (GO:0060046)3.08355375
44indole-containing compound metabolic process (GO:0042430)3.07833553
45neuronal action potential (GO:0019228)3.07776551
46inner ear receptor stereocilium organization (GO:0060122)3.03469469
47cilium movement (GO:0003341)3.00918320
48nonmotile primary cilium assembly (GO:0035058)2.98393623
49axoneme assembly (GO:0035082)2.96660584
50replication fork processing (GO:0031297)2.94563158
51kynurenine metabolic process (GO:0070189)2.94373354
52neuronal action potential propagation (GO:0019227)2.94217849
53regulation of establishment of cell polarity (GO:2000114)2.92312034
54response to pheromone (GO:0019236)2.92227352
55aromatic amino acid family catabolic process (GO:0009074)2.87646387
56high-density lipoprotein particle remodeling (GO:0034375)2.85673655
57interkinetic nuclear migration (GO:0022027)2.83582428
58motile cilium assembly (GO:0044458)2.82499383
59gamma-aminobutyric acid transport (GO:0015812)2.81431287
60neural tube formation (GO:0001841)2.81085565
61fusion of sperm to egg plasma membrane (GO:0007342)2.80769920
62protein targeting to Golgi (GO:0000042)2.80175555
63regulation of phosphoprotein phosphatase activity (GO:0043666)2.79052620
64double-strand break repair via homologous recombination (GO:0000724)2.76431300
65organic cation transport (GO:0015695)2.75843982
66recombinational repair (GO:0000725)2.74807485
67spermatid development (GO:0007286)2.74629662
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.73537521
69regulation of translation, ncRNA-mediated (GO:0045974)2.73537521
70negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73537521
71regulation of glucokinase activity (GO:0033131)2.72673224
72regulation of hexokinase activity (GO:1903299)2.72673224
73centriole replication (GO:0007099)2.70998115
74oxidative demethylation (GO:0070989)2.70819466
75positive regulation of glycolytic process (GO:0045821)2.67337846
76cilium organization (GO:0044782)2.67056239
77signal peptide processing (GO:0006465)2.66327121
78regulation of cilium movement (GO:0003352)2.66146962
79resolution of meiotic recombination intermediates (GO:0000712)2.65282925
80cilium assembly (GO:0042384)2.63842586
81activation of protein kinase B activity (GO:0032148)2.61691153
82membrane depolarization during action potential (GO:0086010)2.61293076
83reverse cholesterol transport (GO:0043691)2.61187255
84negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.61006931
85positive regulation of meiotic cell cycle (GO:0051446)2.56779156
86behavioral response to ethanol (GO:0048149)2.56638454
87positive regulation of meiosis (GO:0045836)2.55823765
88adaptation of signaling pathway (GO:0023058)2.55451271
89sulfation (GO:0051923)2.54602598
90regulation of establishment or maintenance of cell polarity (GO:0032878)2.53647154
91chromosome organization involved in meiosis (GO:0070192)2.52098942
92aromatic amino acid family metabolic process (GO:0009072)2.50490772
93meiotic chromosome segregation (GO:0045132)2.49007233
94protein localization to Golgi apparatus (GO:0034067)2.48792772
95UDP-N-acetylglucosamine metabolic process (GO:0006047)2.48434046
96cellular biogenic amine catabolic process (GO:0042402)2.46330750
97amine catabolic process (GO:0009310)2.46330750
98benzene-containing compound metabolic process (GO:0042537)2.44729054
99positive regulation of catecholamine secretion (GO:0033605)2.43510727
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43478127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.37318795
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.40496058
3VDR_22108803_ChIP-Seq_LS180_Human3.23472942
4ZNF274_21170338_ChIP-Seq_K562_Hela3.04592820
5IGF1R_20145208_ChIP-Seq_DFB_Human2.82126762
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.60511021
7EZH2_22144423_ChIP-Seq_EOC_Human2.60345716
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54117857
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.53934228
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50427252
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.50286100
12ER_23166858_ChIP-Seq_MCF-7_Human2.41798711
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.27752482
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26958176
15FUS_26573619_Chip-Seq_HEK293_Human2.16913132
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16905069
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12028495
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07304060
19P300_19829295_ChIP-Seq_ESCs_Human2.03325056
20BCAT_22108803_ChIP-Seq_LS180_Human1.97733234
21EWS_26573619_Chip-Seq_HEK293_Human1.94920907
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.93313728
23STAT3_23295773_ChIP-Seq_U87_Human1.91921604
24TAF15_26573619_Chip-Seq_HEK293_Human1.88850820
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87185951
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.84157656
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82352525
28SMAD4_21799915_ChIP-Seq_A2780_Human1.81008138
29AR_21572438_ChIP-Seq_LNCaP_Human1.80544611
30TCF4_23295773_ChIP-Seq_U87_Human1.77205405
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73079988
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68944324
33CBP_20019798_ChIP-Seq_JUKART_Human1.68944324
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63407167
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63012895
36AR_25329375_ChIP-Seq_VCAP_Human1.62694387
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58822497
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56125522
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53549579
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.53520029
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50529471
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50529471
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.49397880
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.48479978
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45592265
46NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45042232
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.43307848
48SALL1_21062744_ChIP-ChIP_HESCs_Human1.41488599
49AHR_22903824_ChIP-Seq_MCF-7_Human1.41385615
50TCF4_22108803_ChIP-Seq_LS180_Human1.40368992
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.40333038
52RUNX2_22187159_ChIP-Seq_PCA_Human1.38779319
53TP53_16413492_ChIP-PET_HCT116_Human1.36718889
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28446632
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.28374958
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27790659
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.27440150
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.24579576
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23707441
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23672489
61IRF1_19129219_ChIP-ChIP_H3396_Human1.22262840
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21850373
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20386804
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19553013
65RXR_22108803_ChIP-Seq_LS180_Human1.19200761
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19171174
67CDX2_22108803_ChIP-Seq_LS180_Human1.17891737
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17836301
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17835303
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17393605
71SOX2_19829295_ChIP-Seq_ESCs_Human1.17050911
72NANOG_19829295_ChIP-Seq_ESCs_Human1.17050911
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16160745
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14716768
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12996201
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.12832884
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.12753171
78TP53_22573176_ChIP-Seq_HFKS_Human1.12117886
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11989374
80NFE2_27457419_Chip-Seq_LIVER_Mouse1.09166914
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09145930
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.08793397
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08767346
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07426351
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07057224
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04058471
87HOXB7_26014856_ChIP-Seq_BT474_Human1.01853902
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01691926
89KDM2B_26808549_Chip-Seq_REH_Human1.01559371
90CBX2_27304074_Chip-Seq_ESCs_Mouse0.98803277
91P53_22387025_ChIP-Seq_ESCs_Mouse0.98416644
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98197930
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97897091
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97699450
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97511692
96REST_21632747_ChIP-Seq_MESCs_Mouse0.96193094
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.95585135
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.94577246
99TBL1_22424771_ChIP-Seq_293T_Human0.94392011
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.94128436

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.44993632
2MP0005410_abnormal_fertilization3.29569634
3MP0002736_abnormal_nociception_after3.02452210
4MP0001968_abnormal_touch/_nociception2.84975880
5MP0003195_calcinosis2.75998148
6MP0005551_abnormal_eye_electrophysiolog2.72911010
7MP0000569_abnormal_digit_pigmentation2.72666022
8MP0008877_abnormal_DNA_methylation2.69341507
9MP0003136_yellow_coat_color2.46550782
10MP0009046_muscle_twitch2.39810871
11MP0005646_abnormal_pituitary_gland2.33146557
12MP0003646_muscle_fatigue2.32640318
13MP0004043_abnormal_pH_regulation2.02631435
14MP0002102_abnormal_ear_morphology1.89104123
15MP0008872_abnormal_physiological_respon1.83760372
16MP0009780_abnormal_chondrocyte_physiolo1.80268587
17MP0001984_abnormal_olfaction1.78634223
18MP0001501_abnormal_sleep_pattern1.76279171
19MP0001486_abnormal_startle_reflex1.75413408
20MP0005670_abnormal_white_adipose1.75222676
21MP0010329_abnormal_lipoprotein_level1.69598745
22MP0000427_abnormal_hair_cycle1.67123234
23MP0003698_abnormal_male_reproductive1.66242302
24MP0001929_abnormal_gametogenesis1.65023767
25MP0002160_abnormal_reproductive_system1.61262162
26MP0003045_fibrosis1.60726491
27MP0005174_abnormal_tail_pigmentation1.59666766
28MP0001986_abnormal_taste_sensitivity1.49472010
29MP0005647_abnormal_sex_gland1.45815682
30MP0009745_abnormal_behavioral_response1.45441717
31MP0000631_abnormal_neuroendocrine_gland1.42559815
32MP0005645_abnormal_hypothalamus_physiol1.41711799
33MP0008875_abnormal_xenobiotic_pharmacok1.40510561
34MP0005253_abnormal_eye_physiology1.36135649
35MP0002272_abnormal_nervous_system1.34409821
36MP0002876_abnormal_thyroid_physiology1.33869382
37MP0000372_irregular_coat_pigmentation1.33668766
38MP0004742_abnormal_vestibular_system1.31786725
39MP0002837_dystrophic_cardiac_calcinosis1.30755561
40MP0009697_abnormal_copulation1.30146370
41MP0001485_abnormal_pinna_reflex1.29589046
42MP0002210_abnormal_sex_determination1.27303118
43MP0004147_increased_porphyrin_level1.26668056
44MP0003787_abnormal_imprinting1.23850839
45MP0005389_reproductive_system_phenotype1.22354760
46MP0002938_white_spotting1.22093388
47MP0000383_abnormal_hair_follicle1.20530598
48MP0004381_abnormal_hair_follicle1.19692883
49MP0008995_early_reproductive_senescence1.18459317
50MP0002168_other_aberrant_phenotype1.17943503
51MP0010386_abnormal_urinary_bladder1.17079305
52MP0002067_abnormal_sensory_capabilities1.16519405
53MP0002638_abnormal_pupillary_reflex1.14679443
54MP0001664_abnormal_digestion1.13668458
55MP0005085_abnormal_gallbladder_physiolo1.10370414
56MP0005408_hypopigmentation1.09458393
57MP0002064_seizures1.08743565
58MP0000653_abnormal_sex_gland1.06848561
59MP0003252_abnormal_bile_duct1.04598282
60MP0002138_abnormal_hepatobiliary_system1.04170991
61MP0001666_abnormal_nutrient_absorption1.03850687
62MP0001145_abnormal_male_reproductive1.01375591
63MP0003718_maternal_effect1.00366328
64MP0005379_endocrine/exocrine_gland_phen0.95688424
65MP0005395_other_phenotype0.93818652
66MP0008961_abnormal_basal_metabolism0.93131448
67MP0002557_abnormal_social/conspecific_i0.92625715
68MP0000639_abnormal_adrenal_gland0.92549070
69MP0004885_abnormal_endolymph0.92005395
70MP0001919_abnormal_reproductive_system0.91687267
71MP0003635_abnormal_synaptic_transmissio0.91634529
72MP0002928_abnormal_bile_duct0.91508585
73MP0004145_abnormal_muscle_electrophysio0.90334585
74MP0003633_abnormal_nervous_system0.89555012
75MP0003950_abnormal_plasma_membrane0.88424617
76MP0005365_abnormal_bile_salt0.87090478
77MP0001270_distended_abdomen0.86694695
78MP0002572_abnormal_emotion/affect_behav0.86566253
79MP0003183_abnormal_peptide_metabolism0.85542553
80MP0002229_neurodegeneration0.84465634
81MP0001963_abnormal_hearing_physiology0.81070482
82MP0005636_abnormal_mineral_homeostasis0.80918271
83MP0004215_abnormal_myocardial_fiber0.80137114
84MP0003631_nervous_system_phenotype0.78610913
85MP0004924_abnormal_behavior0.77258528
86MP0005386_behavior/neurological_phenoty0.77258528
87MP0005360_urolithiasis0.76370195
88MP0003936_abnormal_reproductive_system0.75366122
89MP0006292_abnormal_olfactory_placode0.74631083
90MP0005266_abnormal_metabolism0.74516343
91MP0002132_abnormal_respiratory_system0.73441947
92MP0000015_abnormal_ear_pigmentation0.73430438
93MP0002095_abnormal_skin_pigmentation0.72787555
94MP0001764_abnormal_homeostasis0.72337349
95MP0002161_abnormal_fertility/fecundity0.72222119
96MP0006276_abnormal_autonomic_nervous0.71965417
97MP0003315_abnormal_perineum_morphology0.71847500
98MP0000538_abnormal_urinary_bladder0.71544946
99MP0000026_abnormal_inner_ear0.70936651
100MP0010678_abnormal_skin_adnexa0.70852877

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.43825114
2Congenital sensorineural hearing impairment (HP:0008527)4.29799322
3Pancreatic cysts (HP:0001737)4.07833670
4Gaze-evoked nystagmus (HP:0000640)3.59882964
5Pancreatic fibrosis (HP:0100732)3.57374210
6Protruding tongue (HP:0010808)3.55859407
7Chronic hepatic failure (HP:0100626)3.47934500
8True hermaphroditism (HP:0010459)3.39871028
9Abnormality of the renal cortex (HP:0011035)3.36515186
10Cerebellar dysplasia (HP:0007033)3.22509108
11Attenuation of retinal blood vessels (HP:0007843)3.18475012
12Febrile seizures (HP:0002373)3.14419476
13Molar tooth sign on MRI (HP:0002419)3.02948996
14Abnormality of midbrain morphology (HP:0002418)3.02948996
15Type II lissencephaly (HP:0007260)3.00028703
16Cystic liver disease (HP:0006706)2.98764551
17Absent speech (HP:0001344)2.78034085
18Aplasia/Hypoplasia of the tibia (HP:0005772)2.74580995
19Renal cortical cysts (HP:0000803)2.71286723
20Intestinal atresia (HP:0011100)2.69460985
21Facial hemangioma (HP:0000329)2.66388006
22Absent/shortened dynein arms (HP:0200106)2.64301914
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.64301914
24Congenital stationary night blindness (HP:0007642)2.63463096
25Large for gestational age (HP:0001520)2.62595382
26Medial flaring of the eyebrow (HP:0010747)2.55793559
27Male pseudohermaphroditism (HP:0000037)2.52576352
28Polydipsia (HP:0001959)2.52489082
29Abnormal drinking behavior (HP:0030082)2.52489082
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52326324
31Abnormality of alanine metabolism (HP:0010916)2.52326324
32Hyperalaninemia (HP:0003348)2.52326324
33Hypothermia (HP:0002045)2.51337540
34Pigmentary retinal degeneration (HP:0001146)2.44726903
35Nephronophthisis (HP:0000090)2.44214231
36Fair hair (HP:0002286)2.41235059
37Atonic seizures (HP:0010819)2.40911759
38Abnormality of the renal medulla (HP:0100957)2.40544299
39Bony spicule pigmentary retinopathy (HP:0007737)2.40154621
40Chromsome breakage (HP:0040012)2.39278511
41Tubular atrophy (HP:0000092)2.38701051
42Clumsiness (HP:0002312)2.35645280
43Bile duct proliferation (HP:0001408)2.34607568
44Abnormal biliary tract physiology (HP:0012439)2.34607568
45Abnormality of the ileum (HP:0001549)2.32465524
46Volvulus (HP:0002580)2.27638805
47Hypoplastic labia majora (HP:0000059)2.26045190
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.26016026
49Enlarged kidneys (HP:0000105)2.25840673
50Abolished electroretinogram (ERG) (HP:0000550)2.25713616
51Furrowed tongue (HP:0000221)2.21744727
52Abnormal rod and cone electroretinograms (HP:0008323)2.19414662
53Spontaneous abortion (HP:0005268)2.17093391
54Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15470180
55Meckel diverticulum (HP:0002245)2.15077673
56Focal seizures (HP:0007359)2.13335888
57Abnormal ciliary motility (HP:0012262)2.12631310
58Broad-based gait (HP:0002136)2.09835775
59Generalized hypopigmentation of hair (HP:0011358)2.09078114
60Inability to walk (HP:0002540)2.08804838
61Supernumerary spleens (HP:0009799)2.07450848
62Widely spaced teeth (HP:0000687)2.07342981
63Hypobetalipoproteinemia (HP:0003563)2.07144100
64Abnormality of the labia majora (HP:0012881)2.06794249
65Acanthocytosis (HP:0001927)2.05730114
66Clubbing of toes (HP:0100760)2.05353735
67Hemiparesis (HP:0001269)2.03005676
68Decreased central vision (HP:0007663)2.02766011
69Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01102637
70Congenital primary aphakia (HP:0007707)2.00803509
71Congenital hepatic fibrosis (HP:0002612)1.98649595
72Tubulointerstitial nephritis (HP:0001970)1.98220343
73Abnormality of chromosome stability (HP:0003220)1.97378681
74Gait imbalance (HP:0002141)1.97165401
75Astigmatism (HP:0000483)1.96979377
76Progressive cerebellar ataxia (HP:0002073)1.96591939
77Aplasia/Hypoplasia of the tongue (HP:0010295)1.94797876
78Poor coordination (HP:0002370)1.94684269
79Focal motor seizures (HP:0011153)1.93885215
80Epidermoid cyst (HP:0200040)1.93177046
81Genetic anticipation (HP:0003743)1.93053661
82Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89593404
83Genital tract atresia (HP:0001827)1.88892807
84Concave nail (HP:0001598)1.87678930
85Dyskinesia (HP:0100660)1.86831082
86Absence seizures (HP:0002121)1.86504400
87Abnormal sex determination (HP:0012244)1.86330484
88Sex reversal (HP:0012245)1.86330484
89Constricted visual fields (HP:0001133)1.84325028
90Sloping forehead (HP:0000340)1.83299404
91Capillary hemangiomas (HP:0005306)1.80264622
92Pancreatic islet-cell hyperplasia (HP:0004510)1.80152428
93Abnormal respiratory epithelium morphology (HP:0012253)1.78743011
94Abnormal respiratory motile cilium morphology (HP:0005938)1.78743011
95Vaginal atresia (HP:0000148)1.76870633
96Abnormal respiratory motile cilium physiology (HP:0012261)1.74423317
97Anencephaly (HP:0002323)1.73463857
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71741396
99Polyuria (HP:0000103)1.71684625
100Gastrointestinal atresia (HP:0002589)1.71201649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.60271409
2PINK14.66089407
3BMPR1B2.59740142
4ACVR1B2.52449794
5NUAK12.37507348
6MARK32.12740895
7ADRBK21.92649186
8MAPK131.83543927
9BRSK21.77638269
10INSRR1.75377573
11NTRK31.72438619
12PLK41.65925386
13ZAK1.64636204
14WNK41.60512233
15FGFR21.59998716
16CASK1.59862867
17WEE11.56162665
18MKNK21.55421824
19LATS11.45434177
20PTK2B1.41550158
21GRK11.41098537
22NEK21.40600003
23TLK11.31059944
24MAP4K21.28549963
25STK391.27723723
26TAOK31.20101762
27AKT31.18516803
28WNK31.18107708
29PAK31.15533316
30MAP3K41.12159626
31PNCK1.11653553
32CDK31.08761937
33PIK3CA1.06595979
34SGK21.01919554
35PIK3CG1.00428802
36OBSCN0.99290463
37PLK20.97153282
38STK38L0.94352329
39CCNB10.93551834
40PRKCQ0.88298418
41MAP2K70.84700484
42SGK2230.79961551
43SGK4940.79961551
44PKN10.79176783
45RPS6KB20.77025108
46PRKCE0.72914288
47ADRBK10.71988232
48TNIK0.71496551
49DMPK0.71459345
50STK30.70814164
51MAP2K60.67826467
52TRPM70.67429839
53STK380.65347746
54SIK20.62976908
55CSNK1D0.62428585
56MYLK0.60846650
57CAMK2A0.59458722
58PRKCG0.58830324
59MAPKAPK30.58513624
60RPS6KA50.57261694
61CAMK2D0.56630347
62ATM0.55944730
63OXSR10.55919299
64RPS6KB10.54926069
65MAP3K20.53265622
66MST40.52839960
67TNK20.52679222
68PDK20.52548377
69ROCK10.50494626
70MELK0.50414201
71NLK0.50412769
72SGK30.50040747
73MAP3K70.49798172
74CAMK2B0.49609864
75TGFBR10.49578531
76FLT30.48593094
77PRKAA20.47386156
78PBK0.47216604
79FGFR30.46039784
80TEC0.44313782
81SGK10.42765547
82MAPK110.41109051
83PHKG20.40705471
84PHKG10.40705471
85PRKG10.40424914
86WNK10.40122206
87DAPK20.39639854
88CSNK1G10.38273236
89PRKAA10.36724132
90VRK10.35295638
91CSNK1A1L0.34737453
92CAMK1G0.34633938
93CSNK1A10.33502692
94CAMK10.32744028
95MAP2K10.32268085
96EPHA40.30241742
97PRKACA0.30108454
98CAMK40.29706017
99CAMKK20.29369400
100PRKCB0.29102746

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.27269814
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.15765586
3Nitrogen metabolism_Homo sapiens_hsa009102.85315395
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33860782
5ABC transporters_Homo sapiens_hsa020102.23848629
6Phototransduction_Homo sapiens_hsa047442.16235723
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.15643635
8Olfactory transduction_Homo sapiens_hsa047402.07056806
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.04846639
10Linoleic acid metabolism_Homo sapiens_hsa005912.03354443
11Propanoate metabolism_Homo sapiens_hsa006401.96704295
12Tryptophan metabolism_Homo sapiens_hsa003801.96502088
13Nicotine addiction_Homo sapiens_hsa050331.92240976
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86279474
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82337909
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.81584501
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81369890
18Fat digestion and absorption_Homo sapiens_hsa049751.80622345
19Homologous recombination_Homo sapiens_hsa034401.79874442
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.75289097
21Fanconi anemia pathway_Homo sapiens_hsa034601.71112506
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69528496
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68584171
24Chemical carcinogenesis_Homo sapiens_hsa052041.67030346
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52076682
26Taste transduction_Homo sapiens_hsa047421.46566362
27Ether lipid metabolism_Homo sapiens_hsa005651.44258026
28Dorso-ventral axis formation_Homo sapiens_hsa043201.41052195
29Fatty acid degradation_Homo sapiens_hsa000711.36397439
30Glycerolipid metabolism_Homo sapiens_hsa005611.30031260
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24075924
32Selenocompound metabolism_Homo sapiens_hsa004501.20038855
33PPAR signaling pathway_Homo sapiens_hsa033201.18430791
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18252774
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17696001
36Salivary secretion_Homo sapiens_hsa049701.15537348
37Calcium signaling pathway_Homo sapiens_hsa040201.13972878
38Retinol metabolism_Homo sapiens_hsa008301.10762882
39Fatty acid metabolism_Homo sapiens_hsa012121.09150925
40Circadian entrainment_Homo sapiens_hsa047131.08711688
41Peroxisome_Homo sapiens_hsa041461.04929674
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.04474180
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04303623
44beta-Alanine metabolism_Homo sapiens_hsa004101.02964512
45Lysine degradation_Homo sapiens_hsa003101.02231548
46Caffeine metabolism_Homo sapiens_hsa002321.01511215
47Fatty acid biosynthesis_Homo sapiens_hsa000611.01383791
48Glutamatergic synapse_Homo sapiens_hsa047240.96615498
49Circadian rhythm_Homo sapiens_hsa047100.96453168
50Ovarian steroidogenesis_Homo sapiens_hsa049130.92228877
51One carbon pool by folate_Homo sapiens_hsa006700.91150929
52Histidine metabolism_Homo sapiens_hsa003400.91015601
53Morphine addiction_Homo sapiens_hsa050320.90388391
54Renin secretion_Homo sapiens_hsa049240.88380715
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88137105
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83662823
57Vitamin digestion and absorption_Homo sapiens_hsa049770.83615755
58Glycerophospholipid metabolism_Homo sapiens_hsa005640.83585181
59Insulin secretion_Homo sapiens_hsa049110.82270949
60Regulation of autophagy_Homo sapiens_hsa041400.82001437
61Complement and coagulation cascades_Homo sapiens_hsa046100.80254160
62Arginine biosynthesis_Homo sapiens_hsa002200.75545586
63Sphingolipid metabolism_Homo sapiens_hsa006000.71585435
64Serotonergic synapse_Homo sapiens_hsa047260.70542393
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68591634
66Non-homologous end-joining_Homo sapiens_hsa034500.68408913
67Arachidonic acid metabolism_Homo sapiens_hsa005900.67284484
68RNA degradation_Homo sapiens_hsa030180.66948258
69Basal transcription factors_Homo sapiens_hsa030220.66661620
70Oxytocin signaling pathway_Homo sapiens_hsa049210.66040679
71GABAergic synapse_Homo sapiens_hsa047270.58473668
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57473024
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54362911
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53684574
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53487454
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52624209
77Gastric acid secretion_Homo sapiens_hsa049710.50629982
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50588424
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50055783
80Purine metabolism_Homo sapiens_hsa002300.49511819
81N-Glycan biosynthesis_Homo sapiens_hsa005100.49425096
82Pancreatic secretion_Homo sapiens_hsa049720.48945422
83cAMP signaling pathway_Homo sapiens_hsa040240.47029149
84Glutathione metabolism_Homo sapiens_hsa004800.45608648
85Amphetamine addiction_Homo sapiens_hsa050310.44123877
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.42970029
87Metabolic pathways_Homo sapiens_hsa011000.39883231
88Hedgehog signaling pathway_Homo sapiens_hsa043400.39633822
89Mineral absorption_Homo sapiens_hsa049780.39499406
90Dopaminergic synapse_Homo sapiens_hsa047280.37638328
91Primary immunodeficiency_Homo sapiens_hsa053400.35623705
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34011527
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33699629
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33593054
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32850132
96Graft-versus-host disease_Homo sapiens_hsa053320.32477076
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32453985
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32231401
99Gap junction_Homo sapiens_hsa045400.31829725
100Glucagon signaling pathway_Homo sapiens_hsa049220.28369567

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