ANKRD20A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.87461892
2indole-containing compound catabolic process (GO:0042436)4.59005240
3indolalkylamine catabolic process (GO:0046218)4.59005240
4tryptophan catabolic process (GO:0006569)4.59005240
5indolalkylamine metabolic process (GO:0006586)4.35410564
6synapsis (GO:0007129)4.25912972
7kynurenine metabolic process (GO:0070189)4.24951068
8gamma-aminobutyric acid transport (GO:0015812)3.95377200
9behavioral response to nicotine (GO:0035095)3.90499677
10signal peptide processing (GO:0006465)3.88040895
11tryptophan metabolic process (GO:0006568)3.85671610
12cellular ketone body metabolic process (GO:0046950)3.81252770
13piRNA metabolic process (GO:0034587)3.64106415
14detection of light stimulus involved in sensory perception (GO:0050962)3.61394995
15detection of light stimulus involved in visual perception (GO:0050908)3.61394995
16photoreceptor cell maintenance (GO:0045494)3.59518840
17ketone body metabolic process (GO:1902224)3.58318212
18indole-containing compound metabolic process (GO:0042430)3.49042633
19startle response (GO:0001964)3.47464384
20DNA methylation involved in gamete generation (GO:0043046)3.47253018
21cilium or flagellum-dependent cell motility (GO:0001539)3.42992451
22detection of mechanical stimulus involved in sensory perception (GO:0050974)3.42382839
23sulfation (GO:0051923)3.41649901
24auditory receptor cell stereocilium organization (GO:0060088)3.39787776
25regulation of meiosis I (GO:0060631)3.37155299
26reflex (GO:0060004)3.26670852
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.23076759
28male meiosis (GO:0007140)3.22794883
29regulation of cilium movement (GO:0003352)3.20472126
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.14925853
31monoubiquitinated protein deubiquitination (GO:0035520)3.10444673
32L-fucose catabolic process (GO:0042355)3.09974973
33fucose catabolic process (GO:0019317)3.09974973
34L-fucose metabolic process (GO:0042354)3.09974973
35serotonin metabolic process (GO:0042428)3.09855074
36behavioral response to ethanol (GO:0048149)3.08327675
37centriole replication (GO:0007099)3.07826377
38response to pheromone (GO:0019236)3.04005946
39reciprocal meiotic recombination (GO:0007131)3.03294645
40reciprocal DNA recombination (GO:0035825)3.03294645
41neuronal action potential (GO:0019228)2.94319018
42male meiosis I (GO:0007141)2.93354487
43chromosome organization involved in meiosis (GO:0070192)2.92181718
44meiotic chromosome segregation (GO:0045132)2.91118434
45righting reflex (GO:0060013)2.89189924
46amine catabolic process (GO:0009310)2.82120626
47cellular biogenic amine catabolic process (GO:0042402)2.82120626
48aromatic amino acid family catabolic process (GO:0009074)2.82109037
49interkinetic nuclear migration (GO:0022027)2.81562246
50positive regulation of meiosis (GO:0045836)2.81074810
51negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80991568
52benzene-containing compound metabolic process (GO:0042537)2.80688841
53nonmotile primary cilium assembly (GO:0035058)2.77880088
54oxidative demethylation (GO:0070989)2.77103773
55transmission of nerve impulse (GO:0019226)2.76748505
56resolution of meiotic recombination intermediates (GO:0000712)2.76485045
57membrane depolarization during action potential (GO:0086010)2.74092192
58recombinational repair (GO:0000725)2.71900581
59establishment of protein localization to Golgi (GO:0072600)2.71605336
60glutamate receptor signaling pathway (GO:0007215)2.71211273
61double-strand break repair via homologous recombination (GO:0000724)2.70988826
62inner ear receptor stereocilium organization (GO:0060122)2.69952775
63regulation of hippo signaling (GO:0035330)2.69599981
64axoneme assembly (GO:0035082)2.69495291
65cilium organization (GO:0044782)2.69267672
66protein K11-linked deubiquitination (GO:0035871)2.66305824
67dopamine transport (GO:0015872)2.65325249
68cilium morphogenesis (GO:0060271)2.65311021
69cilium assembly (GO:0042384)2.64926126
70proline transport (GO:0015824)2.64720778
71primary amino compound metabolic process (GO:1901160)2.64441648
72neural tube formation (GO:0001841)2.63541320
73positive regulation of meiotic cell cycle (GO:0051446)2.62300417
74presynaptic membrane assembly (GO:0097105)2.61033873
75negative regulation of DNA-dependent DNA replication (GO:2000104)2.59299246
76aromatic amino acid family metabolic process (GO:0009072)2.57976689
77anterograde synaptic vesicle transport (GO:0048490)2.57093330
78sensory perception of smell (GO:0007608)2.56591594
79replication fork processing (GO:0031297)2.55887690
80multicellular organism reproduction (GO:0032504)2.52724449
81ionotropic glutamate receptor signaling pathway (GO:0035235)2.51060472
82retinal cone cell development (GO:0046549)2.50085930
83protein polyglutamylation (GO:0018095)2.47748693
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47327040
85NAD biosynthetic process (GO:0009435)2.46426547
86epithelial cilium movement (GO:0003351)2.45945476
87thyroid hormone metabolic process (GO:0042403)2.45193483
88detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.43469808
89synaptic transmission, glutamatergic (GO:0035249)2.42121253
90neuron cell-cell adhesion (GO:0007158)2.41569720
91cellular response to sterol (GO:0036315)2.39967213
92regulation of sarcomere organization (GO:0060297)2.36775831
933-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.33638576
94purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.33638576
95sperm motility (GO:0030317)2.33503390
96regulation of rhodopsin mediated signaling pathway (GO:0022400)2.33364933
97positive regulation of glycolytic process (GO:0045821)2.33162540
98methionine biosynthetic process (GO:0009086)2.32589750
99microtubule anchoring (GO:0034453)2.31549497
100postsynaptic membrane organization (GO:0001941)2.29817347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.70495350
2EZH2_22144423_ChIP-Seq_EOC_Human3.43147744
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.18662435
4VDR_22108803_ChIP-Seq_LS180_Human3.13326221
5IGF1R_20145208_ChIP-Seq_DFB_Human3.08101324
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.91972895
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.81476002
8* ZNF274_21170338_ChIP-Seq_K562_Hela2.79731441
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.75057256
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.66691605
11TAF15_26573619_Chip-Seq_HEK293_Human2.31985194
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27054376
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22718479
14FUS_26573619_Chip-Seq_HEK293_Human2.19995589
15ER_23166858_ChIP-Seq_MCF-7_Human2.17893277
16P300_19829295_ChIP-Seq_ESCs_Human2.17132531
17EWS_26573619_Chip-Seq_HEK293_Human2.14617742
18SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11056986
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.03242895
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01510684
21STAT3_23295773_ChIP-Seq_U87_Human1.92139400
22SMAD4_21799915_ChIP-Seq_A2780_Human1.91818233
23UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83709015
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.77643715
25BCAT_22108803_ChIP-Seq_LS180_Human1.77403100
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.71337147
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70494942
28TCF4_23295773_ChIP-Seq_U87_Human1.69919800
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69443099
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65840153
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61761812
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61698963
33CBP_20019798_ChIP-Seq_JUKART_Human1.61698963
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60854303
35AR_25329375_ChIP-Seq_VCAP_Human1.60437865
36SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59597404
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50287845
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49779526
39SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49576757
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46224035
41AR_21572438_ChIP-Seq_LNCaP_Human1.46028176
42* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45138630
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43613447
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43613447
45TCF4_22108803_ChIP-Seq_LS180_Human1.42476857
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42245169
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.41686398
48RUNX2_22187159_ChIP-Seq_PCA_Human1.41509571
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40403164
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34060958
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33644844
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32582086
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.32069902
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.30370570
55NANOG_19829295_ChIP-Seq_ESCs_Human1.29109189
56SOX2_19829295_ChIP-Seq_ESCs_Human1.29109189
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29041648
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.27581073
59RNF2_27304074_Chip-Seq_NSC_Mouse1.27472586
60REST_21632747_ChIP-Seq_MESCs_Mouse1.26598697
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23189954
62* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21487278
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20395039
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.20323594
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20258304
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19492243
67CDX2_22108803_ChIP-Seq_LS180_Human1.18857649
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.18818529
69TP53_22573176_ChIP-Seq_HFKS_Human1.18755289
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.18066236
71IRF1_19129219_ChIP-ChIP_H3396_Human1.14451393
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.13690867
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13688396
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12119280
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10992322
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10659934
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09816818
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08780059
79TP53_16413492_ChIP-PET_HCT116_Human1.08148612
80P53_22387025_ChIP-Seq_ESCs_Mouse1.08120815
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07720090
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06536321
83FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05919240
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.05919240
85RXR_22108803_ChIP-Seq_LS180_Human1.04283699
86FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03772546
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03524429
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02811342
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.02224949
90TBL1_22424771_ChIP-Seq_293T_Human1.02160280
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.00869588
92JUN_21703547_ChIP-Seq_K562_Human1.00772343
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.00316274
94CRX_20693478_ChIP-Seq_RETINA_Mouse0.99980005
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99504559
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.99258118
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.98834375
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98272650
99CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96464218
100HTT_18923047_ChIP-ChIP_STHdh_Human0.95475360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.24287208
2MP0003195_calcinosis3.11061702
3MP0008877_abnormal_DNA_methylation2.66402553
4MP0002736_abnormal_nociception_after2.62521073
5MP0001968_abnormal_touch/_nociception2.55028888
6MP0000372_irregular_coat_pigmentation2.54294623
7MP0000569_abnormal_digit_pigmentation2.51522679
8MP0005551_abnormal_eye_electrophysiolog2.48347590
9MP0001485_abnormal_pinna_reflex2.37633303
10MP0009046_muscle_twitch2.29856405
11MP0005171_absent_coat_pigmentation2.17514120
12MP0008057_abnormal_DNA_replication2.05056437
13MP0001501_abnormal_sleep_pattern1.96558580
14MP0009745_abnormal_behavioral_response1.92436116
15MP0003646_muscle_fatigue1.92123201
16MP0004885_abnormal_endolymph1.91828967
17MP0005646_abnormal_pituitary_gland1.87566289
18MP0004043_abnormal_pH_regulation1.86021186
19MP0004147_increased_porphyrin_level1.85729695
20MP0005174_abnormal_tail_pigmentation1.83625404
21MP0002272_abnormal_nervous_system1.76902850
22MP0002102_abnormal_ear_morphology1.74709660
23MP0000427_abnormal_hair_cycle1.72198856
24MP0006276_abnormal_autonomic_nervous1.66444814
25MP0000631_abnormal_neuroendocrine_gland1.62914624
26MP0002837_dystrophic_cardiac_calcinosis1.60916174
27MP0005253_abnormal_eye_physiology1.60401073
28MP0005410_abnormal_fertilization1.59594098
29MP0001486_abnormal_startle_reflex1.59395805
30MP0008872_abnormal_physiological_respon1.56851544
31MP0002638_abnormal_pupillary_reflex1.48059092
32MP0010386_abnormal_urinary_bladder1.47340183
33MP0004142_abnormal_muscle_tone1.44744542
34MP0002938_white_spotting1.42391531
35MP0002064_seizures1.40658168
36MP0008058_abnormal_DNA_repair1.40203263
37MP0003718_maternal_effect1.35211977
38MP0003698_abnormal_male_reproductive1.35206109
39MP0001986_abnormal_taste_sensitivity1.33658457
40MP0002572_abnormal_emotion/affect_behav1.33501265
41MP0001929_abnormal_gametogenesis1.32309862
42MP0002067_abnormal_sensory_capabilities1.31257666
43MP0003635_abnormal_synaptic_transmissio1.30463406
44MP0006072_abnormal_retinal_apoptosis1.29215890
45MP0002160_abnormal_reproductive_system1.27785908
46MP0005377_hearing/vestibular/ear_phenot1.26444413
47MP0003878_abnormal_ear_physiology1.26444413
48MP0002735_abnormal_chemical_nociception1.25192240
49MP0002095_abnormal_skin_pigmentation1.23628328
50MP0001970_abnormal_pain_threshold1.23377060
51MP0002876_abnormal_thyroid_physiology1.22895690
52MP0002210_abnormal_sex_determination1.22053510
53MP0002557_abnormal_social/conspecific_i1.20524731
54MP0009780_abnormal_chondrocyte_physiolo1.20061831
55MP0004742_abnormal_vestibular_system1.17754030
56MP0003950_abnormal_plasma_membrane1.17695357
57MP0005085_abnormal_gallbladder_physiolo1.14715564
58MP0004215_abnormal_myocardial_fiber1.14257545
59MP0006292_abnormal_olfactory_placode1.13194655
60MP0005645_abnormal_hypothalamus_physiol1.12922976
61MP0002734_abnormal_mechanical_nocicepti1.07181381
62MP0002733_abnormal_thermal_nociception1.07025774
63MP0002063_abnormal_learning/memory/cond1.06921621
64MP0001984_abnormal_olfaction1.06732769
65MP0002928_abnormal_bile_duct1.05697429
66MP0004924_abnormal_behavior1.04446506
67MP0005386_behavior/neurological_phenoty1.04446506
68MP0005187_abnormal_penis_morphology1.04135284
69MP0002229_neurodegeneration1.01806611
70MP0004145_abnormal_muscle_electrophysio1.01474051
71MP0001963_abnormal_hearing_physiology1.00387021
72MP0000230_abnormal_systemic_arterial0.99740827
73MP0003787_abnormal_imprinting0.97732356
74MP0003880_abnormal_central_pattern0.96836836
75MP0002090_abnormal_vision0.96826127
76MP0005389_reproductive_system_phenotype0.96675762
77MP0008995_early_reproductive_senescence0.95463247
78MP0000653_abnormal_sex_gland0.93622689
79MP0000647_abnormal_sebaceous_gland0.92320344
80MP0001145_abnormal_male_reproductive0.90623338
81MP0003879_abnormal_hair_cell0.89659169
82MP0000383_abnormal_hair_follicle0.89533173
83MP0001529_abnormal_vocalization0.86947735
84MP0000026_abnormal_inner_ear0.86234392
85MP0002909_abnormal_adrenal_gland0.84857607
86MP0010094_abnormal_chromosome_stability0.84830609
87MP0008875_abnormal_xenobiotic_pharmacok0.84587388
88MP0004085_abnormal_heartbeat0.83914116
89MP0005195_abnormal_posterior_eye0.80672018
90MP0003633_abnormal_nervous_system0.79758467
91MP0003252_abnormal_bile_duct0.79616451
92MP0000538_abnormal_urinary_bladder0.78810885
93MP0009697_abnormal_copulation0.76719966
94MP0001324_abnormal_eye_pigmentation0.76149694
95MP0010329_abnormal_lipoprotein_level0.75639090
96MP0002138_abnormal_hepatobiliary_system0.74108060
97MP0003137_abnormal_impulse_conducting0.73034009
98MP0002882_abnormal_neuron_morphology0.71464731
99MP0005395_other_phenotype0.70998262
100MP0002234_abnormal_pharynx_morphology0.70515396

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.47069446
2Pancreatic cysts (HP:0001737)4.26458661
3Pancreatic fibrosis (HP:0100732)4.13904946
4True hermaphroditism (HP:0010459)4.06497266
5Gaze-evoked nystagmus (HP:0000640)3.57443064
6Congenital stationary night blindness (HP:0007642)3.51415760
7Molar tooth sign on MRI (HP:0002419)3.51200107
8Abnormality of midbrain morphology (HP:0002418)3.51200107
9Attenuation of retinal blood vessels (HP:0007843)3.17211939
10Congenital sensorineural hearing impairment (HP:0008527)3.11835714
11Progressive cerebellar ataxia (HP:0002073)3.00598597
12Large for gestational age (HP:0001520)2.95453169
13Nephronophthisis (HP:0000090)2.93875494
14Abnormality of the renal cortex (HP:0011035)2.87258586
15Cystic liver disease (HP:0006706)2.85602000
16Type II lissencephaly (HP:0007260)2.83963936
17Protruding tongue (HP:0010808)2.83606663
18Medial flaring of the eyebrow (HP:0010747)2.75286942
19Abnormality of the renal medulla (HP:0100957)2.73887868
20Aplasia/Hypoplasia of the tibia (HP:0005772)2.72442732
21Sclerocornea (HP:0000647)2.67206692
22Fair hair (HP:0002286)2.57731570
23Genetic anticipation (HP:0003743)2.55599718
24Chronic hepatic failure (HP:0100626)2.53877676
25Furrowed tongue (HP:0000221)2.47955205
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.36763960
27Abnormality of alanine metabolism (HP:0010916)2.36612425
28Hyperalaninemia (HP:0003348)2.36612425
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.36612425
30Absent speech (HP:0001344)2.33863197
31Cerebellar dysplasia (HP:0007033)2.32698377
32Bony spicule pigmentary retinopathy (HP:0007737)2.31003962
33Febrile seizures (HP:0002373)2.30265057
34Focal seizures (HP:0007359)2.29374957
35Inability to walk (HP:0002540)2.27964890
36Abolished electroretinogram (ERG) (HP:0000550)2.24904409
37Gait imbalance (HP:0002141)2.24553238
38Concave nail (HP:0001598)2.23012333
39Broad-based gait (HP:0002136)2.20301972
40Hemiparesis (HP:0001269)2.19926594
41Congenital hepatic fibrosis (HP:0002612)2.19823047
42Congenital primary aphakia (HP:0007707)2.19125679
43Anencephaly (HP:0002323)2.18888214
44Tubular atrophy (HP:0000092)2.15535310
45Male pseudohermaphroditism (HP:0000037)2.12413742
46Abnormal biliary tract physiology (HP:0012439)2.12101446
47Bile duct proliferation (HP:0001408)2.12101446
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.11776010
49Absent/shortened dynein arms (HP:0200106)2.11776010
50Congenital, generalized hypertrichosis (HP:0004540)2.10755637
51Generalized hypopigmentation of hair (HP:0011358)2.10371800
52Abnormal rod and cone electroretinograms (HP:0008323)2.06659253
53Chromsome breakage (HP:0040012)2.06291342
54Genital tract atresia (HP:0001827)2.05215046
55Focal motor seizures (HP:0011153)2.05209643
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.03833965
57Decreased central vision (HP:0007663)2.03435282
58Hypoplastic labia majora (HP:0000059)2.02982035
59Clumsiness (HP:0002312)2.02837206
60Hypoplasia of the fovea (HP:0007750)2.01609457
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.01609457
62Renal cortical cysts (HP:0000803)2.01333083
63Hypothermia (HP:0002045)2.01203255
64Preaxial hand polydactyly (HP:0001177)2.00918536
65Abnormality of the pons (HP:0007361)2.00374415
66Hypoplasia of the pons (HP:0012110)1.98911603
67Optic nerve hypoplasia (HP:0000609)1.98390748
68Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98286105
69Polydipsia (HP:0001959)1.97752209
70Abnormal drinking behavior (HP:0030082)1.97752209
71Progressive inability to walk (HP:0002505)1.97502860
72Postaxial foot polydactyly (HP:0001830)1.97269790
73Nephrogenic diabetes insipidus (HP:0009806)1.93802658
74Dialeptic seizures (HP:0011146)1.92105221
75Birth length less than 3rd percentile (HP:0003561)1.91626176
76Vaginal atresia (HP:0000148)1.90963174
77Duplicated collecting system (HP:0000081)1.90248182
78Constricted visual fields (HP:0001133)1.90049545
79Abnormality of the renal collecting system (HP:0004742)1.89884036
80Abnormality of the labia majora (HP:0012881)1.87866735
81Astigmatism (HP:0000483)1.86120868
82Progressive macrocephaly (HP:0004481)1.86091330
83Abnormal ciliary motility (HP:0012262)1.84839510
84Blue irides (HP:0000635)1.84047128
85Widely spaced teeth (HP:0000687)1.82739909
86Ketoacidosis (HP:0001993)1.82711532
87Abnormality of the ileum (HP:0001549)1.82353152
88Absence seizures (HP:0002121)1.81695466
89Intestinal atresia (HP:0011100)1.81149563
90Poor coordination (HP:0002370)1.80708293
91Small hand (HP:0200055)1.80288340
92Acute necrotizing encephalopathy (HP:0006965)1.79437604
93Acute encephalopathy (HP:0006846)1.78764646
94Lissencephaly (HP:0001339)1.77580222
95Abnormality of the labia minora (HP:0012880)1.76843288
96Oligodactyly (hands) (HP:0001180)1.76720628
97Meckel diverticulum (HP:0002245)1.76208686
98Epileptic encephalopathy (HP:0200134)1.75971653
99Tubulointerstitial nephritis (HP:0001970)1.75369056
100Drooling (HP:0002307)1.75083893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.27563887
2CASK2.95002212
3PNCK2.92585205
4ZAK2.38540403
5ACVR1B2.27621313
6ADRBK22.27376208
7NUAK12.24058777
8BMPR1B2.16393519
9PINK12.11190232
10INSRR2.09725535
11TAOK32.01115328
12MAPK131.98226272
13WNK31.95367651
14STK391.91185442
15MKNK21.87470320
16GRK11.83857771
17WEE11.78200673
18MAP4K21.69535720
19WNK41.59162617
20NTRK31.58353330
21MAP3K41.41145519
22NEK21.37581900
23CCNB11.35223320
24OXSR11.22733771
25PLK21.22090881
26NEK11.17862535
27STK31.15757585
28PAK31.15597269
29MAPK151.14306001
30STK38L1.08196457
31PDK21.07389390
32PLK41.07339620
33PTK2B1.05488569
34ADRBK11.01004830
35BRSK21.00421024
36TNIK0.99757091
37PRKCG0.98757806
38MAPKAPK30.97649728
39MAPKAPK50.88764044
40LATS10.84046965
41PRKCE0.79303780
42MKNK10.77878921
43MAP2K70.71423584
44TGFBR10.71227783
45TLK10.70679978
46PHKG20.69863899
47PHKG10.69863899
48AKT30.69562385
49MARK30.67605352
50EIF2AK30.66572285
51MARK10.66511328
52PLK30.66181311
53CAMK2A0.64872887
54PKN10.63320810
55MUSK0.60674881
56CDK30.60069507
57FGFR20.59367438
58SIK20.58908614
59TSSK60.58316997
60NTRK20.58265546
61DAPK20.58056920
62CAMK1G0.57813826
63TEC0.57640182
64FER0.56865058
65PLK10.52806216
66PIK3CG0.52779536
67VRK10.52269122
68TRPM70.49306234
69ATM0.44947926
70PRKAA20.44484743
71NME10.44246662
72CHEK20.43281024
73CSNK1G20.43199738
74CSNK1G10.43128932
75TRIM280.40878533
76SGK20.39220643
77DMPK0.37889130
78OBSCN0.37593639
79PRKACA0.37574017
80CAMK10.37219027
81PRKAA10.35745980
82MST40.34819383
83NLK0.34270796
84CSNK1A10.33992228
85BCR0.33879710
86TIE10.33374699
87PIK3CA0.33162911
88CAMKK20.32612485
89CAMK2B0.32210277
90PRKACB0.31866984
91TTK0.31581976
92CSNK1A1L0.31452952
93RPS6KA50.30654475
94CSNK1D0.30011264
95EIF2AK10.29413310
96IRAK10.29265775
97ATR0.28504058
98TNK20.27113500
99CAMK2D0.26577525
100CSNK1G30.26524672

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006503.38476338
2Nicotine addiction_Homo sapiens_hsa050332.93354196
3Phototransduction_Homo sapiens_hsa047442.58848561
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56624809
5Homologous recombination_Homo sapiens_hsa034402.53821970
6Nitrogen metabolism_Homo sapiens_hsa009102.30411070
7Tryptophan metabolism_Homo sapiens_hsa003802.26488797
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.24315575
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.20379472
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.06007228
11Linoleic acid metabolism_Homo sapiens_hsa005912.01761553
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01083805
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94667417
14Propanoate metabolism_Homo sapiens_hsa006401.93434214
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.93105639
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90967902
17Fanconi anemia pathway_Homo sapiens_hsa034601.86692223
18Olfactory transduction_Homo sapiens_hsa047401.82987705
19ABC transporters_Homo sapiens_hsa020101.80437956
20Taste transduction_Homo sapiens_hsa047421.76274548
21Selenocompound metabolism_Homo sapiens_hsa004501.74318723
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65348093
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.60497438
24Morphine addiction_Homo sapiens_hsa050321.45341383
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42961332
26Ether lipid metabolism_Homo sapiens_hsa005651.41691009
27Circadian entrainment_Homo sapiens_hsa047131.38794104
28Glutamatergic synapse_Homo sapiens_hsa047241.34396673
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32642188
30GABAergic synapse_Homo sapiens_hsa047271.27308325
31Chemical carcinogenesis_Homo sapiens_hsa052041.25866304
32Retinol metabolism_Homo sapiens_hsa008301.19200050
33Insulin secretion_Homo sapiens_hsa049111.19187959
34Basal transcription factors_Homo sapiens_hsa030221.18596690
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18350640
36Protein export_Homo sapiens_hsa030601.17650916
37One carbon pool by folate_Homo sapiens_hsa006701.16301934
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14511124
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13005369
40Serotonergic synapse_Homo sapiens_hsa047261.12653404
41beta-Alanine metabolism_Homo sapiens_hsa004101.07719131
42Salivary secretion_Homo sapiens_hsa049701.06973757
43Ovarian steroidogenesis_Homo sapiens_hsa049131.04625281
44Calcium signaling pathway_Homo sapiens_hsa040201.03374367
45Oxidative phosphorylation_Homo sapiens_hsa001901.02448161
46Peroxisome_Homo sapiens_hsa041461.02280010
47Caffeine metabolism_Homo sapiens_hsa002320.97859567
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96789911
49Dorso-ventral axis formation_Homo sapiens_hsa043200.94325001
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94057536
51Fatty acid metabolism_Homo sapiens_hsa012120.84734569
52Fatty acid biosynthesis_Homo sapiens_hsa000610.84635610
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83516767
54Steroid biosynthesis_Homo sapiens_hsa001000.82221612
55Fatty acid degradation_Homo sapiens_hsa000710.79846028
56Parkinsons disease_Homo sapiens_hsa050120.78843236
57Amphetamine addiction_Homo sapiens_hsa050310.77044256
58Glycerolipid metabolism_Homo sapiens_hsa005610.77011395
59Cocaine addiction_Homo sapiens_hsa050300.76591075
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76438000
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75480844
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74933200
63Purine metabolism_Homo sapiens_hsa002300.72225292
64Circadian rhythm_Homo sapiens_hsa047100.71417800
65Dopaminergic synapse_Homo sapiens_hsa047280.70531506
66RNA degradation_Homo sapiens_hsa030180.69714562
67RNA polymerase_Homo sapiens_hsa030200.69571874
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.69419567
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67209013
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67200382
71Long-term depression_Homo sapiens_hsa047300.66315712
72Histidine metabolism_Homo sapiens_hsa003400.62652822
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.62418886
74Huntingtons disease_Homo sapiens_hsa050160.60792573
75Lysine degradation_Homo sapiens_hsa003100.60361190
76Arachidonic acid metabolism_Homo sapiens_hsa005900.59289261
77Regulation of autophagy_Homo sapiens_hsa041400.57576857
78Cardiac muscle contraction_Homo sapiens_hsa042600.56840405
79Mismatch repair_Homo sapiens_hsa034300.56384848
80Fat digestion and absorption_Homo sapiens_hsa049750.55416878
81cAMP signaling pathway_Homo sapiens_hsa040240.55182640
82Metabolic pathways_Homo sapiens_hsa011000.54218436
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51978208
84Mineral absorption_Homo sapiens_hsa049780.51335170
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49950326
86Non-homologous end-joining_Homo sapiens_hsa034500.48886671
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48681942
88Sphingolipid metabolism_Homo sapiens_hsa006000.47064165
89Oxytocin signaling pathway_Homo sapiens_hsa049210.47052686
90Type II diabetes mellitus_Homo sapiens_hsa049300.46107237
91Cholinergic synapse_Homo sapiens_hsa047250.46036836
92Alzheimers disease_Homo sapiens_hsa050100.44853568
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.44681929
94Nucleotide excision repair_Homo sapiens_hsa034200.44247165
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43921441
96Renin secretion_Homo sapiens_hsa049240.41158906
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40468326
98Oocyte meiosis_Homo sapiens_hsa041140.38892256
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.38743764
100Gastric acid secretion_Homo sapiens_hsa049710.38551256

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