ANKRD20A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.84563515
2central nervous system myelination (GO:0022010)5.84563515
3nephron epithelium morphogenesis (GO:0072088)4.92652472
4nephron tubule morphogenesis (GO:0072078)4.92652472
5negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.65884412
6neuron fate determination (GO:0048664)4.64377148
7negative regulation of astrocyte differentiation (GO:0048712)4.49900029
8auditory receptor cell differentiation (GO:0042491)4.42659676
9neuronal stem cell maintenance (GO:0097150)4.40007043
10renal tubule morphogenesis (GO:0061333)4.31973539
11otic vesicle formation (GO:0030916)4.06887503
12tongue development (GO:0043586)4.06758196
13centriole replication (GO:0007099)3.87298942
14neuronal action potential propagation (GO:0019227)3.74983211
15presynaptic membrane assembly (GO:0097105)3.74298594
16astrocyte differentiation (GO:0048708)3.74183104
17regulation of mesenchymal cell apoptotic process (GO:2001053)3.71849922
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.56270809
19postsynaptic membrane organization (GO:0001941)3.55492835
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.45321848
21pattern specification involved in kidney development (GO:0061004)3.43215638
22membrane depolarization during action potential (GO:0086010)3.37653743
23negative regulation of inclusion body assembly (GO:0090084)3.37026136
24cerebral cortex radially oriented cell migration (GO:0021799)3.36188056
25negative regulation of oligodendrocyte differentiation (GO:0048715)3.33822087
26inner ear receptor cell differentiation (GO:0060113)3.28082598
27regulation of microtubule-based movement (GO:0060632)3.23249982
28heart valve formation (GO:0003188)3.19594517
29adaptation of signaling pathway (GO:0023058)3.19551303
30neuronal action potential (GO:0019228)3.18010435
31multicellular organism reproduction (GO:0032504)3.17402727
32presynaptic membrane organization (GO:0097090)3.14716406
33cilium or flagellum-dependent cell motility (GO:0001539)3.13113818
34gamma-aminobutyric acid transport (GO:0015812)3.08253216
35forebrain neuron differentiation (GO:0021879)3.06334817
36nonmotile primary cilium assembly (GO:0035058)3.05676583
37behavioral response to nicotine (GO:0035095)3.04297416
38epithelial cilium movement (GO:0003351)3.03918932
39limb bud formation (GO:0060174)3.03489760
40protein polyglutamylation (GO:0018095)3.01854720
41male sex determination (GO:0030238)2.95795896
42startle response (GO:0001964)2.92820166
43regulation of male gonad development (GO:2000018)2.91532979
44positive regulation of vascular permeability (GO:0043117)2.91465081
45positive regulation of male gonad development (GO:2000020)2.90870537
46axonemal dynein complex assembly (GO:0070286)2.88107716
47axoneme assembly (GO:0035082)2.87690150
48protein localization to synapse (GO:0035418)2.86162642
49neuron cell-cell adhesion (GO:0007158)2.84965305
50sperm motility (GO:0030317)2.84934666
51negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.84427315
52negative regulation of glial cell differentiation (GO:0045686)2.83285103
53regulation of cellular respiration (GO:0043457)2.82279972
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81794129
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79982624
56radial glial cell differentiation (GO:0060019)2.78990166
57regulation of cilium movement (GO:0003352)2.77433532
58mechanoreceptor differentiation (GO:0042490)2.77411619
59negative regulation of appetite (GO:0032099)2.75856052
60negative regulation of response to food (GO:0032096)2.75856052
61cilium movement (GO:0003341)2.74044365
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.73596858
63auditory behavior (GO:0031223)2.71462951
64retina layer formation (GO:0010842)2.70732230
65telencephalon development (GO:0021537)2.68267543
66G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67019413
67L-fucose catabolic process (GO:0042355)2.63275799
68fucose catabolic process (GO:0019317)2.63275799
69L-fucose metabolic process (GO:0042354)2.63275799
70cilium organization (GO:0044782)2.62125012
71cochlea development (GO:0090102)2.61308421
72regulation of hexokinase activity (GO:1903299)2.61117534
73regulation of glucokinase activity (GO:0033131)2.61117534
74cellular ketone body metabolic process (GO:0046950)2.59087034
75detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58306782
76centriole assembly (GO:0098534)2.57845833
77negative regulation of telomere maintenance (GO:0032205)2.57396118
78nephron tubule formation (GO:0072079)2.54923918
79resolution of meiotic recombination intermediates (GO:0000712)2.54512987
80mechanosensory behavior (GO:0007638)2.53717080
81protein refolding (GO:0042026)2.53487593
82regulation of response to food (GO:0032095)2.53177056
83negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50640751
84neurotransmitter-gated ion channel clustering (GO:0072578)2.50503381
85glutamate receptor signaling pathway (GO:0007215)2.50192257
86negative regulation of mast cell activation (GO:0033004)2.49757836
87spermatid nucleus differentiation (GO:0007289)2.48655410
88synaptic transmission, glutamatergic (GO:0035249)2.48348414
89establishment of protein localization to mitochondrial membrane (GO:0090151)2.47806291
90regulation of astrocyte differentiation (GO:0048710)2.45467055
91cilium assembly (GO:0042384)2.45106501
92mannosylation (GO:0097502)2.43767320
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40424390
94regulation of action potential (GO:0098900)2.40334778
95replication fork processing (GO:0031297)2.38298337
96substrate-independent telencephalic tangential migration (GO:0021826)2.38234162
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.38234162
98hindbrain development (GO:0030902)2.37445546
99negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37165580
100ATP synthesis coupled proton transport (GO:0015986)2.36420107

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.11712275
2GBX2_23144817_ChIP-Seq_PC3_Human3.22153035
3ZNF274_21170338_ChIP-Seq_K562_Hela2.84834801
4VDR_22108803_ChIP-Seq_LS180_Human2.63095587
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51716177
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.38460531
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33597056
8* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30896032
9* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30672638
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28773614
11FUS_26573619_Chip-Seq_HEK293_Human2.18845049
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08919392
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99287356
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98238568
15EZH2_27304074_Chip-Seq_ESCs_Mouse1.95709999
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.88795786
17P300_19829295_ChIP-Seq_ESCs_Human1.87743438
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.85140501
19* TAF15_26573619_Chip-Seq_HEK293_Human1.84045488
20IGF1R_20145208_ChIP-Seq_DFB_Human1.83403562
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79412084
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.78501510
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78501510
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78018298
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.77937995
26EWS_26573619_Chip-Seq_HEK293_Human1.74478178
27AR_21572438_ChIP-Seq_LNCaP_Human1.74227380
28REST_21632747_ChIP-Seq_MESCs_Mouse1.71499822
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69507887
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67733265
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67354033
32* ER_23166858_ChIP-Seq_MCF-7_Human1.66195566
33AR_25329375_ChIP-Seq_VCAP_Human1.63350812
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60845544
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57566948
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57371269
37RNF2_27304074_Chip-Seq_NSC_Mouse1.56923368
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56610110
39SMAD4_21799915_ChIP-Seq_A2780_Human1.54845452
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54701729
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53177485
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53103536
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53055547
44STAT3_23295773_ChIP-Seq_U87_Human1.52470221
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51585259
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50646410
47BCAT_22108803_ChIP-Seq_LS180_Human1.48420941
48CBP_20019798_ChIP-Seq_JUKART_Human1.47524927
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47524927
50IRF1_19129219_ChIP-ChIP_H3396_Human1.44381755
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43951697
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.42889232
53TCF4_23295773_ChIP-Seq_U87_Human1.42674226
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41871308
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41472664
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41196374
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.40916182
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40314297
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39216790
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39216790
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.39184233
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38519231
63SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37781182
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37048735
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.36773928
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33961686
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33874028
68TP53_16413492_ChIP-PET_HCT116_Human1.30589855
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.29490969
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29437896
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27963031
72TCF4_22108803_ChIP-Seq_LS180_Human1.26593104
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25341903
74REST_18959480_ChIP-ChIP_MESCs_Mouse1.23701745
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23255676
76RUNX2_22187159_ChIP-Seq_PCA_Human1.22041181
77* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18838929
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18223564
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.15883925
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15755987
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.14930434
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14406474
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13937266
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13248430
85KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13121389
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13068578
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12946678
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11961654
89MYC_18940864_ChIP-ChIP_HL60_Human1.11804702
90SOX2_19829295_ChIP-Seq_ESCs_Human1.11724895
91NANOG_19829295_ChIP-Seq_ESCs_Human1.11724895
92JUN_21703547_ChIP-Seq_K562_Human1.09504399
93TP53_22573176_ChIP-Seq_HFKS_Human1.09231930
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.08312240
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.07808797
96RXR_22108803_ChIP-Seq_LS180_Human1.04645665
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.03059664
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03047496
99TAL1_26923725_Chip-Seq_HPCs_Mouse1.02409118
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01820701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.74830133
2MP0004885_abnormal_endolymph3.55905078
3MP0001485_abnormal_pinna_reflex3.00567561
4MP0001968_abnormal_touch/_nociception2.54044896
5MP0002638_abnormal_pupillary_reflex2.47556787
6MP0002736_abnormal_nociception_after2.45674207
7MP0003880_abnormal_central_pattern2.38800076
8MP0004742_abnormal_vestibular_system2.37503069
9MP0008877_abnormal_DNA_methylation2.20114536
10MP0009745_abnormal_behavioral_response2.06505297
11MP0005551_abnormal_eye_electrophysiolog2.05790157
12MP0004142_abnormal_muscle_tone2.05112055
13MP0002272_abnormal_nervous_system2.04117221
14MP0006292_abnormal_olfactory_placode2.03829976
15MP0002822_catalepsy1.90563423
16MP0003787_abnormal_imprinting1.89254483
17MP0001486_abnormal_startle_reflex1.82353948
18MP0001984_abnormal_olfaction1.79975682
19MP0004147_increased_porphyrin_level1.78303583
20MP0006072_abnormal_retinal_apoptosis1.77577622
21MP0001529_abnormal_vocalization1.75783830
22MP0000631_abnormal_neuroendocrine_gland1.75517777
23MP0003635_abnormal_synaptic_transmissio1.73364913
24MP0009384_cardiac_valve_regurgitation1.72323974
25MP0002102_abnormal_ear_morphology1.70291104
26MP0005646_abnormal_pituitary_gland1.69817883
27MP0009046_muscle_twitch1.69137980
28MP0002064_seizures1.68551696
29MP0002067_abnormal_sensory_capabilities1.66011285
30MP0005423_abnormal_somatic_nervous1.63809933
31MP0000566_synostosis1.56135273
32MP0001986_abnormal_taste_sensitivity1.54988990
33MP0002572_abnormal_emotion/affect_behav1.53319248
34MP0000026_abnormal_inner_ear1.52100633
35MP0005253_abnormal_eye_physiology1.50544254
36MP0000049_abnormal_middle_ear1.49828790
37MP0002653_abnormal_ependyma_morphology1.49468030
38MP0002557_abnormal_social/conspecific_i1.48996010
39MP0001963_abnormal_hearing_physiology1.39885721
40MP0000569_abnormal_digit_pigmentation1.38456643
41MP0003283_abnormal_digestive_organ1.38187508
42MP0003122_maternal_imprinting1.37697155
43MP0002735_abnormal_chemical_nociception1.36569972
44MP0002063_abnormal_learning/memory/cond1.36226231
45MP0004043_abnormal_pH_regulation1.35820475
46MP0000778_abnormal_nervous_system1.35320677
47MP0002938_white_spotting1.34104401
48MP0004270_analgesia1.33123126
49MP0002249_abnormal_larynx_morphology1.32659565
50MP0002734_abnormal_mechanical_nocicepti1.30615183
51MP0004859_abnormal_synaptic_plasticity1.29773201
52MP0002733_abnormal_thermal_nociception1.28624687
53MP0005377_hearing/vestibular/ear_phenot1.25992157
54MP0003878_abnormal_ear_physiology1.25992157
55MP0001970_abnormal_pain_threshold1.25924682
56MP0003121_genomic_imprinting1.24738188
57MP0005195_abnormal_posterior_eye1.22555668
58MP0008872_abnormal_physiological_respon1.21628087
59MP0000427_abnormal_hair_cycle1.20773178
60MP0002282_abnormal_trachea_morphology1.19143985
61MP0000955_abnormal_spinal_cord1.18135452
62MP0003195_calcinosis1.16156909
63MP0004924_abnormal_behavior1.15988381
64MP0005386_behavior/neurological_phenoty1.15988381
65MP0008058_abnormal_DNA_repair1.12881224
66MP0001905_abnormal_dopamine_level1.10811035
67MP0005187_abnormal_penis_morphology1.09311097
68MP0006276_abnormal_autonomic_nervous1.09171531
69MP0001929_abnormal_gametogenesis1.07949802
70MP0002184_abnormal_innervation1.07748625
71MP0004133_heterotaxia1.06982930
72MP0002752_abnormal_somatic_nervous1.02789556
73MP0002882_abnormal_neuron_morphology1.02738159
74MP0003698_abnormal_male_reproductive1.01909551
75MP0002160_abnormal_reproductive_system1.01504074
76MP0001764_abnormal_homeostasis1.00789018
77MP0001502_abnormal_circadian_rhythm1.00575099
78MP0002229_neurodegeneration0.99019494
79MP0002837_dystrophic_cardiac_calcinosis0.96695182
80MP0005410_abnormal_fertilization0.94724364
81MP0002234_abnormal_pharynx_morphology0.94571216
82MP0005391_vision/eye_phenotype0.93326127
83MP0003755_abnormal_palate_morphology0.89997529
84MP0002928_abnormal_bile_duct0.89262144
85MP0005174_abnormal_tail_pigmentation0.88319742
86MP0002210_abnormal_sex_determination0.87285448
87MP0003633_abnormal_nervous_system0.87228359
88MP0002095_abnormal_skin_pigmentation0.87040588
89MP0009780_abnormal_chondrocyte_physiolo0.86345753
90MP0001299_abnormal_eye_distance/0.84977034
91MP0001293_anophthalmia0.84568101
92MP0002152_abnormal_brain_morphology0.83913460
93MP0005084_abnormal_gallbladder_morpholo0.83889237
94MP0000534_abnormal_ureter_morphology0.82616858
95MP0000613_abnormal_salivary_gland0.82227682
96MP0003890_abnormal_embryonic-extraembry0.81899535
97MP0001270_distended_abdomen0.80234378
98MP0001440_abnormal_grooming_behavior0.79206686
99MP0001324_abnormal_eye_pigmentation0.78203828
100MP0000647_abnormal_sebaceous_gland0.78126404

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.37528657
2Molar tooth sign on MRI (HP:0002419)4.37528657
3True hermaphroditism (HP:0010459)4.27025869
4Hypoplastic iliac wings (HP:0002866)3.77607717
5Medial flaring of the eyebrow (HP:0010747)3.59190341
611 pairs of ribs (HP:0000878)3.45990856
7Pancreatic fibrosis (HP:0100732)3.44085835
8Nephronophthisis (HP:0000090)3.38076324
9Hyperventilation (HP:0002883)3.34653391
10Type II lissencephaly (HP:0007260)3.23483541
11Pancreatic cysts (HP:0001737)3.11356881
12Chronic hepatic failure (HP:0100626)2.99125274
13Cerebellar dysplasia (HP:0007033)2.96483579
14Tubular atrophy (HP:0000092)2.86731618
15Morphological abnormality of the inner ear (HP:0011390)2.81498261
16Abnormality of the renal medulla (HP:0100957)2.79499047
17Abnormal ciliary motility (HP:0012262)2.76095011
18Gait imbalance (HP:0002141)2.75355512
19Abnormality of the renal cortex (HP:0011035)2.71260846
20Sex reversal (HP:0012245)2.69492596
21Abnormal sex determination (HP:0012244)2.69492596
22Aplasia/Hypoplasia of the sternum (HP:0006714)2.60269778
23Congenital primary aphakia (HP:0007707)2.54466736
24Hemiparesis (HP:0001269)2.53292528
25Focal motor seizures (HP:0011153)2.48048697
26Nephrogenic diabetes insipidus (HP:0009806)2.47740211
27Male pseudohermaphroditism (HP:0000037)2.47002754
28Septo-optic dysplasia (HP:0100842)2.46665001
29Abnormal drinking behavior (HP:0030082)2.40266409
30Polydipsia (HP:0001959)2.40266409
31Abnormal respiratory epithelium morphology (HP:0012253)2.40034360
32Abnormal respiratory motile cilium morphology (HP:0005938)2.40034360
33Broad-based gait (HP:0002136)2.37248104
34Acute necrotizing encephalopathy (HP:0006965)2.34219561
35Genital tract atresia (HP:0001827)2.33845320
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.32082483
37Absent/shortened dynein arms (HP:0200106)2.32082483
38Missing ribs (HP:0000921)2.28761653
39Febrile seizures (HP:0002373)2.26282308
40Abnormality of DNA repair (HP:0003254)2.24446088
41Abnormality of the diencephalon (HP:0010662)2.23163624
42Gastrointestinal atresia (HP:0002589)2.17766384
43Large for gestational age (HP:0001520)2.17446151
44Abnormal respiratory motile cilium physiology (HP:0012261)2.16565778
45Vaginal atresia (HP:0000148)2.16545795
46Hypoplastic ilia (HP:0000946)2.14705031
47Abnormality of the wing of the ilium (HP:0011867)2.12651606
48Sclerocornea (HP:0000647)2.10956972
49Conical tooth (HP:0000698)2.08600771
50Cystic liver disease (HP:0006706)2.08454993
51Severe muscular hypotonia (HP:0006829)2.08302651
52Acute encephalopathy (HP:0006846)2.07446778
53Atonic seizures (HP:0010819)2.07192437
54Optic nerve hypoplasia (HP:0000609)2.06802796
55Retinal atrophy (HP:0001105)2.06527715
56Congenital stationary night blindness (HP:0007642)2.06490724
57Renal cortical cysts (HP:0000803)2.03000250
58Congenital hepatic fibrosis (HP:0002612)2.02033077
59Protruding tongue (HP:0010808)2.01775922
60Progressive cerebellar ataxia (HP:0002073)2.00495689
61Progressive macrocephaly (HP:0004481)1.99532403
62Focal seizures (HP:0007359)1.97297692
63Abnormality of the labia minora (HP:0012880)1.93230252
64Retinal dysplasia (HP:0007973)1.91507412
65Abnormal rod and cone electroretinograms (HP:0008323)1.89996750
66Inability to walk (HP:0002540)1.87938306
67Morphological abnormality of the middle ear (HP:0008609)1.87533253
68Poor coordination (HP:0002370)1.86894811
69Lissencephaly (HP:0001339)1.85737683
70Gaze-evoked nystagmus (HP:0000640)1.83839958
71Concave nail (HP:0001598)1.81658321
72Abnormal mitochondria in muscle tissue (HP:0008316)1.81431831
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81070032
74Intestinal atresia (HP:0011100)1.78734612
75Pachygyria (HP:0001302)1.78677156
76Mitochondrial inheritance (HP:0001427)1.78401539
77Increased CSF lactate (HP:0002490)1.77716448
78Esophageal atresia (HP:0002032)1.77547895
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.76611675
80Postaxial hand polydactyly (HP:0001162)1.75686655
81Attenuation of retinal blood vessels (HP:0007843)1.74170751
82Hip dysplasia (HP:0001385)1.72975211
83Abnormality of the pons (HP:0007361)1.72389392
84Median cleft lip (HP:0000161)1.68297990
85Specific learning disability (HP:0001328)1.68254728
86Hypoplasia of the pons (HP:0012110)1.67919157
87Oligodactyly (hands) (HP:0001180)1.67780891
88Tachypnea (HP:0002789)1.66792770
89Hepatic necrosis (HP:0002605)1.66689873
90Hepatocellular necrosis (HP:0001404)1.65776932
91Disproportionate short-trunk short stature (HP:0003521)1.65402132
92Anencephaly (HP:0002323)1.65198560
93Action tremor (HP:0002345)1.64409459
94Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63749442
95Epileptiform EEG discharges (HP:0011182)1.63142309
96Duplicated collecting system (HP:0000081)1.62835039
97Tubulointerstitial abnormality (HP:0001969)1.61969280
98Pendular nystagmus (HP:0012043)1.61558964
99Midline defect of the nose (HP:0004122)1.61201512
100Aganglionic megacolon (HP:0002251)1.60943772

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK5.75724524
2WEE14.42134590
3PINK13.43860760
4TSSK63.43200647
5IRAK13.00574898
6FRK2.79462799
7TAOK32.70769688
8CASK2.53442196
9TNIK2.34698715
10WNK42.21350464
11WNK32.00207017
12MAPK151.99837807
13NTRK31.99305411
14ZAK1.99300243
15STK391.92571884
16NUAK11.87578966
17MAPK131.80265660
18NTRK21.72647662
19PTK2B1.68897574
20ADRBK21.62751545
21GRK11.54597284
22MAPKAPK51.54019655
23BRSK21.49239823
24MKNK21.46144258
25MARK11.25506009
26PLK41.24773551
27BMPR1B1.24542254
28DAPK21.23258891
29PRKCG1.19993649
30CDK31.16009231
31MAP3K41.15355533
32NEK21.08819390
33TIE11.06725861
34UHMK11.02418155
35TRIM280.97298180
36DMPK0.95639875
37LATS10.94409758
38PAK30.90792342
39VRK10.87825028
40BRSK10.85928436
41PLK20.85241463
42MAPKAPK30.81801014
43PAK60.78714253
44CCNB10.74254434
45INSRR0.73868334
46OXSR10.70458927
47MAP2K70.69357147
48DYRK30.69051780
49PKN10.66767626
50PHKG20.66149048
51PHKG10.66149048
52PLK30.64620537
53TAF10.64379025
54STK30.63600083
55EPHA40.62180803
56MAP4K20.61580043
57PRKCE0.60847714
58AKT30.59941468
59PDK20.59186585
60SIK20.58375072
61MAP3K120.58327557
62STK110.58062858
63DYRK20.57810754
64PLK10.57733922
65WNK10.56619069
66MELK0.55230581
67CAMKK20.53114978
68CAMK1G0.52116124
69CAMK2A0.51620527
70ROCK10.51615692
71EPHB20.49797131
72FGFR20.48160795
73ERBB20.47505408
74MARK30.47343552
75ADRBK10.46095637
76TRPM70.45953832
77NLK0.45751750
78CSNK1E0.42735761
79PRKG10.40536608
80PRKACA0.39921339
81CAMK2D0.35321356
82SGK10.34716302
83MKNK10.34212962
84SGK20.33207840
85PRKCQ0.31747586
86ERBB30.31047315
87TTK0.30216929
88SGK4940.29359275
89SGK2230.29359275
90CDC70.29231449
91CAMK2B0.28109133
92PRKD30.28078887
93RPS6KA50.27952954
94CSNK1A10.27863978
95CAMK10.27745129
96LATS20.27684130
97NTRK10.26667785
98EIF2AK20.25441411
99CSNK1G20.24668670
100TEC0.24281771

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.06075225
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.93353848
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69691705
4Butanoate metabolism_Homo sapiens_hsa006502.60410306
5Phototransduction_Homo sapiens_hsa047442.47391309
6Oxidative phosphorylation_Homo sapiens_hsa001902.32973096
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26783390
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16667925
9Morphine addiction_Homo sapiens_hsa050321.90787912
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90026570
11Circadian entrainment_Homo sapiens_hsa047131.89989250
12Taste transduction_Homo sapiens_hsa047421.85633771
13GABAergic synapse_Homo sapiens_hsa047271.85595650
14Parkinsons disease_Homo sapiens_hsa050121.78863514
15Glutamatergic synapse_Homo sapiens_hsa047241.76420714
16Olfactory transduction_Homo sapiens_hsa047401.75525834
17Insulin secretion_Homo sapiens_hsa049111.74015091
18Nitrogen metabolism_Homo sapiens_hsa009101.70824366
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69940904
20Cardiac muscle contraction_Homo sapiens_hsa042601.68505907
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63138853
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58839927
23Linoleic acid metabolism_Homo sapiens_hsa005911.52743753
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.51201638
25Homologous recombination_Homo sapiens_hsa034401.49179677
26Amphetamine addiction_Homo sapiens_hsa050311.48812399
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43700313
28Protein export_Homo sapiens_hsa030601.38539368
29Cocaine addiction_Homo sapiens_hsa050301.38126533
30Alzheimers disease_Homo sapiens_hsa050101.34675275
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34539758
32Dopaminergic synapse_Homo sapiens_hsa047281.29805035
33Regulation of autophagy_Homo sapiens_hsa041401.29431037
34Fanconi anemia pathway_Homo sapiens_hsa034601.28875005
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.28863078
36Huntingtons disease_Homo sapiens_hsa050161.27559121
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25850059
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22780081
39Serotonergic synapse_Homo sapiens_hsa047261.21032049
40Propanoate metabolism_Homo sapiens_hsa006401.15665556
41Ether lipid metabolism_Homo sapiens_hsa005651.15437400
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09622523
43Basal transcription factors_Homo sapiens_hsa030221.08825974
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.06397925
45Peroxisome_Homo sapiens_hsa041461.05663574
46Salivary secretion_Homo sapiens_hsa049701.04661385
47Hedgehog signaling pathway_Homo sapiens_hsa043401.03611381
48Calcium signaling pathway_Homo sapiens_hsa040201.00405122
49Chemical carcinogenesis_Homo sapiens_hsa052040.98638279
50Selenocompound metabolism_Homo sapiens_hsa004500.98608618
51cAMP signaling pathway_Homo sapiens_hsa040240.93240282
52beta-Alanine metabolism_Homo sapiens_hsa004100.92602457
53Caffeine metabolism_Homo sapiens_hsa002320.88666158
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85973756
55Cholinergic synapse_Homo sapiens_hsa047250.85906196
56Steroid biosynthesis_Homo sapiens_hsa001000.85837771
57Renin secretion_Homo sapiens_hsa049240.84702904
58Tryptophan metabolism_Homo sapiens_hsa003800.84509305
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83813188
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83626838
61ABC transporters_Homo sapiens_hsa020100.83147626
62Fat digestion and absorption_Homo sapiens_hsa049750.76763161
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75707345
64Axon guidance_Homo sapiens_hsa043600.72498758
65Basal cell carcinoma_Homo sapiens_hsa052170.71975253
66Mineral absorption_Homo sapiens_hsa049780.71845835
67RNA degradation_Homo sapiens_hsa030180.71257916
68Dorso-ventral axis formation_Homo sapiens_hsa043200.69565871
69Oxytocin signaling pathway_Homo sapiens_hsa049210.69384016
70Gastric acid secretion_Homo sapiens_hsa049710.67163927
71Ribosome_Homo sapiens_hsa030100.65975422
72Retinol metabolism_Homo sapiens_hsa008300.65744204
73Estrogen signaling pathway_Homo sapiens_hsa049150.63787591
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63610223
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58896281
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58799303
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58613138
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58040225
79Long-term depression_Homo sapiens_hsa047300.55624549
80Oocyte meiosis_Homo sapiens_hsa041140.54680385
81Folate biosynthesis_Homo sapiens_hsa007900.53738812
82Fatty acid biosynthesis_Homo sapiens_hsa000610.51484914
83Glycerolipid metabolism_Homo sapiens_hsa005610.51339920
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51268029
85PPAR signaling pathway_Homo sapiens_hsa033200.50869786
86Pancreatic secretion_Homo sapiens_hsa049720.50591498
87Alcoholism_Homo sapiens_hsa050340.49330707
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.48052599
89Synaptic vesicle cycle_Homo sapiens_hsa047210.47930380
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46043086
91Vitamin digestion and absorption_Homo sapiens_hsa049770.46023398
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45228092
93Gap junction_Homo sapiens_hsa045400.45146189
94Type II diabetes mellitus_Homo sapiens_hsa049300.43720647
95Ovarian steroidogenesis_Homo sapiens_hsa049130.43596354
96Fatty acid metabolism_Homo sapiens_hsa012120.42502035
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42211044
98Metabolic pathways_Homo sapiens_hsa011000.41686762
99Hippo signaling pathway_Homo sapiens_hsa043900.40248979
100Sulfur relay system_Homo sapiens_hsa041220.39108148

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