ANKRD18CP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromatin remodeling at centromere (GO:0031055)5.32800303
2histone exchange (GO:0043486)5.17604904
3CENP-A containing nucleosome assembly (GO:0034080)5.03530138
4establishment of integrated proviral latency (GO:0075713)4.87749834
5DNA double-strand break processing (GO:0000729)4.67758222
6regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.49245197
7regulation of mitotic spindle checkpoint (GO:1903504)4.49245197
8regulation of helicase activity (GO:0051095)4.47900069
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.39637016
10DNA replication checkpoint (GO:0000076)4.35330138
11regulation of gene silencing by RNA (GO:0060966)4.19315086
12regulation of posttranscriptional gene silencing (GO:0060147)4.19315086
13regulation of gene silencing by miRNA (GO:0060964)4.19315086
14DNA replication-independent nucleosome organization (GO:0034724)4.14517477
15DNA replication-independent nucleosome assembly (GO:0006336)4.14517477
16negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.07904141
17negative regulation of mitotic sister chromatid segregation (GO:0033048)4.07904141
18negative regulation of mitotic sister chromatid separation (GO:2000816)4.07904141
19negative regulation of sister chromatid segregation (GO:0033046)4.07904141
20negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.07904141
21negative regulation of chromosome segregation (GO:0051985)4.00873384
22pre-miRNA processing (GO:0031054)3.96727419
23telomere maintenance via telomerase (GO:0007004)3.94427608
24IMP biosynthetic process (GO:0006188)3.93916011
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.85529590
26mitotic metaphase plate congression (GO:0007080)3.80927402
27spindle checkpoint (GO:0031577)3.79303847
28heterochromatin organization (GO:0070828)3.79189808
29protein localization to kinetochore (GO:0034501)3.77079431
30mitotic spindle checkpoint (GO:0071174)3.68477253
31establishment of viral latency (GO:0019043)3.67661657
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64631078
33negative regulation of translation, ncRNA-mediated (GO:0040033)3.64631078
34regulation of translation, ncRNA-mediated (GO:0045974)3.64631078
35chaperone-mediated protein transport (GO:0072321)3.62560984
36DNA strand elongation involved in DNA replication (GO:0006271)3.60510308
37IMP metabolic process (GO:0046040)3.60009836
38regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.58894627
39regulation of mitotic metaphase/anaphase transition (GO:0030071)3.58894627
40DNA replication-dependent nucleosome assembly (GO:0006335)3.55491653
41DNA replication-dependent nucleosome organization (GO:0034723)3.55491653
42L-serine metabolic process (GO:0006563)3.53619122
43regulation of sister chromatid segregation (GO:0033045)3.49094299
44regulation of mitotic sister chromatid separation (GO:0010965)3.49094299
45regulation of mitotic sister chromatid segregation (GO:0033047)3.49094299
46mitotic spindle assembly checkpoint (GO:0007094)3.45585422
47purine nucleobase biosynthetic process (GO:0009113)3.45234736
48protein complex localization (GO:0031503)3.44550291
49DNA strand elongation (GO:0022616)3.38851371
50mitotic G2/M transition checkpoint (GO:0044818)3.38484679
51spindle assembly checkpoint (GO:0071173)3.38238990
52ribosome assembly (GO:0042255)3.37514555
53negative regulation of telomerase activity (GO:0051974)3.37343538
54negative regulation of DNA recombination (GO:0045910)3.35715921
55ATP-dependent chromatin remodeling (GO:0043044)3.34371637
56nuclear pore complex assembly (GO:0051292)3.33282666
57telomere maintenance via semi-conservative replication (GO:0032201)3.33213454
58negative regulation of mitosis (GO:0045839)3.30570416
59metaphase plate congression (GO:0051310)3.30524810
60proteasome assembly (GO:0043248)3.26794389
61anterior/posterior axis specification, embryo (GO:0008595)3.23979202
62somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22876092
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.22876092
64regulation of chromosome segregation (GO:0051983)3.22606997
65establishment of protein localization to mitochondrial membrane (GO:0090151)3.20453693
66RNA-dependent DNA replication (GO:0006278)3.20318650
67DNA damage response, detection of DNA damage (GO:0042769)3.19217252
68regulation of telomere maintenance via telomerase (GO:0032210)3.17705811
69DNA catabolic process, exonucleolytic (GO:0000738)3.17695514
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15830068
71synapsis (GO:0007129)3.14310006
72regulation of centriole replication (GO:0046599)3.13858699
73nucleobase biosynthetic process (GO:0046112)3.11029277
74nuclear pore organization (GO:0006999)3.09781658
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09534155
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.07556036
77termination of RNA polymerase III transcription (GO:0006386)3.07556036
78telomere maintenance via telomere lengthening (GO:0010833)3.06963658
79response to X-ray (GO:0010165)3.04444433
80non-recombinational repair (GO:0000726)3.02778899
81double-strand break repair via nonhomologous end joining (GO:0006303)3.02778899
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00910305
83lysine metabolic process (GO:0006553)3.00011276
84lysine catabolic process (GO:0006554)3.00011276
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98856405
86regulation of histone H3-K9 methylation (GO:0051570)2.97301531
87negative regulation of nuclear division (GO:0051784)2.97243718
88replication fork processing (GO:0031297)2.94084386
89regulation of spindle checkpoint (GO:0090231)2.92943567
90histone mRNA metabolic process (GO:0008334)2.92552300
91rRNA modification (GO:0000154)2.91873081
92mitotic sister chromatid cohesion (GO:0007064)2.90958639
93kinetochore organization (GO:0051383)2.89580798
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.89523693
95negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.89399432
96telomere maintenance via recombination (GO:0000722)2.89065474
97chromatin assembly or disassembly (GO:0006333)2.89019148
98mitotic recombination (GO:0006312)2.87429020
99paraxial mesoderm development (GO:0048339)2.85409878
100kinetochore assembly (GO:0051382)2.81638560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.69100646
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80989978
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76629069
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.35368241
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.08114597
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.05341610
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.86536352
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.85832820
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.84804464
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65989919
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.65037641
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59182885
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39188507
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34293090
15POU5F1_16153702_ChIP-ChIP_HESCs_Human2.26640469
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17064270
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16250345
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16250345
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16250345
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.15106992
21ELK1_19687146_ChIP-ChIP_HELA_Human2.11390132
22AR_21909140_ChIP-Seq_LNCAP_Human2.11327410
23FUS_26573619_Chip-Seq_HEK293_Human2.07502019
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05155606
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04477008
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03869078
27NANOG_16153702_ChIP-ChIP_HESCs_Human2.00339530
28SOX2_16153702_ChIP-ChIP_HESCs_Human1.87823384
29EWS_26573619_Chip-Seq_HEK293_Human1.85736579
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.82763236
31IGF1R_20145208_ChIP-Seq_DFB_Human1.82585624
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81491291
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70889114
34MYC_18940864_ChIP-ChIP_HL60_Human1.70833690
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.70296474
36VDR_22108803_ChIP-Seq_LS180_Human1.69732086
37FOXP3_21729870_ChIP-Seq_TREG_Human1.69686608
38ZNF274_21170338_ChIP-Seq_K562_Hela1.68929528
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.67773608
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66251738
41P300_19829295_ChIP-Seq_ESCs_Human1.63818957
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60672977
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.58692587
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58144124
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.57505209
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57300545
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56355122
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52531135
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51904918
50VDR_23849224_ChIP-Seq_CD4+_Human1.50160708
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46558819
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42511792
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41737188
54SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37911700
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34985784
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34771427
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31859825
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31127518
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27026575
60TTF2_22483619_ChIP-Seq_HELA_Human1.25946126
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24870066
62TAF15_26573619_Chip-Seq_HEK293_Human1.23629645
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22528554
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21584099
65TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18366981
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.18208641
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18149065
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.17937442
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14138513
70DCP1A_22483619_ChIP-Seq_HELA_Human1.13388257
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11396095
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10205045
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08098529
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06826783
75CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06488662
76IRF1_19129219_ChIP-ChIP_H3396_Human1.06232171
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03477048
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03463651
79GBX2_23144817_ChIP-Seq_PC3_Human1.03241405
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03087059
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00809022
82POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99335720
83GABP_19822575_ChIP-Seq_HepG2_Human0.98212126
84CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97316727
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96727768
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96727768
87XRN2_22483619_ChIP-Seq_HELA_Human0.95830786
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92629986
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92034830
90YY1_21170310_ChIP-Seq_MESCs_Mouse0.91497752
91SRF_21415370_ChIP-Seq_HL-1_Mouse0.89509960
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88624715
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86927923
94TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86313357
95POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85219588
96TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85208532
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.84424514
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83972561
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.81275412
100NANOG_19829295_ChIP-Seq_ESCs_Human0.80421003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.43175705
2MP0003693_abnormal_embryo_hatching3.86870288
3MP0008877_abnormal_DNA_methylation3.76083461
4MP0010094_abnormal_chromosome_stability3.37732050
5MP0004957_abnormal_blastocyst_morpholog3.34299941
6MP0002254_reproductive_system_inflammat3.30667888
7MP0008058_abnormal_DNA_repair3.22166522
8MP0001188_hyperpigmentation3.16593631
9MP0003111_abnormal_nucleus_morphology3.05612593
10MP0003890_abnormal_embryonic-extraembry2.92305952
11MP0006292_abnormal_olfactory_placode2.89258090
12MP0003718_maternal_effect2.70326031
13MP0003136_yellow_coat_color2.61741568
14MP0008057_abnormal_DNA_replication2.55093306
15MP0008932_abnormal_embryonic_tissue2.40867192
16MP0008007_abnormal_cellular_replicative2.37778987
17MP0003077_abnormal_cell_cycle2.35876261
18MP0001293_anophthalmia2.32080194
19MP0009672_abnormal_birth_weight2.01814715
20MP0003567_abnormal_fetal_cardiomyocyte2.00159815
21MP0005410_abnormal_fertilization1.75437296
22MP0003123_paternal_imprinting1.71554025
23MP0006072_abnormal_retinal_apoptosis1.71398664
24MP0009697_abnormal_copulation1.67122504
25MP0003937_abnormal_limbs/digits/tail_de1.66310335
26MP0003119_abnormal_digestive_system1.64408008
27MP0003787_abnormal_imprinting1.63931276
28MP0003315_abnormal_perineum_morphology1.61555538
29MP0003121_genomic_imprinting1.54977518
30MP0000579_abnormal_nail_morphology1.53359049
31MP0001984_abnormal_olfaction1.47861920
32MP0001730_embryonic_growth_arrest1.45541940
33MP0001529_abnormal_vocalization1.37451615
34MP0004133_heterotaxia1.37366991
35MP0003786_premature_aging1.34066957
36MP0001929_abnormal_gametogenesis1.29490072
37MP0002084_abnormal_developmental_patter1.28825153
38MP0010352_gastrointestinal_tract_polyps1.28642411
39MP0006035_abnormal_mitochondrial_morpho1.27851513
40MP0002085_abnormal_embryonic_tissue1.27807874
41MP0000350_abnormal_cell_proliferation1.26837610
42MP0001286_abnormal_eye_development1.25596855
43MP0009703_decreased_birth_body1.24695503
44MP0001485_abnormal_pinna_reflex1.22643241
45MP0002697_abnormal_eye_size1.21425119
46MP0002102_abnormal_ear_morphology1.19354446
47MP0002938_white_spotting1.17007140
48MP0002160_abnormal_reproductive_system1.15632775
49MP0001177_atelectasis1.15209372
50MP0010307_abnormal_tumor_latency1.14835299
51MP0001672_abnormal_embryogenesis/_devel1.14116931
52MP0005380_embryogenesis_phenotype1.14116931
53MP0001697_abnormal_embryo_size1.13118720
54MP0002233_abnormal_nose_morphology1.10670650
55MP0001299_abnormal_eye_distance/1.09580277
56MP0002210_abnormal_sex_determination1.09304371
57MP0010030_abnormal_orbit_morphology1.07141402
58MP0005499_abnormal_olfactory_system1.07054187
59MP0005394_taste/olfaction_phenotype1.07054187
60MP0002090_abnormal_vision1.06139027
61MP0003698_abnormal_male_reproductive1.06038387
62MP0001145_abnormal_male_reproductive1.04897961
63MP0002736_abnormal_nociception_after1.00540860
64MP0002751_abnormal_autonomic_nervous0.99752350
65MP0000653_abnormal_sex_gland0.97225576
66MP0004197_abnormal_fetal_growth/weight/0.96994602
67MP0005395_other_phenotype0.96480031
68MP0002111_abnormal_tail_morphology0.92316259
69MP0002080_prenatal_lethality0.92287840
70MP0005377_hearing/vestibular/ear_phenot0.90659984
71MP0003878_abnormal_ear_physiology0.90659984
72MP0003984_embryonic_growth_retardation0.90073947
73MP0002088_abnormal_embryonic_growth/wei0.89850093
74MP0000049_abnormal_middle_ear0.89809007
75MP0008789_abnormal_olfactory_epithelium0.88523280
76MP0002277_abnormal_respiratory_mucosa0.87717490
77MP0008995_early_reproductive_senescence0.86466017
78MP0000537_abnormal_urethra_morphology0.80331590
79MP0002796_impaired_skin_barrier0.79846731
80MP0003806_abnormal_nucleotide_metabolis0.78014751
81MP0003186_abnormal_redox_activity0.78000743
82MP0000631_abnormal_neuroendocrine_gland0.77473676
83MP0002161_abnormal_fertility/fecundity0.76228247
84MP0000428_abnormal_craniofacial_morphol0.74276567
85MP0003861_abnormal_nervous_system0.72412021
86MP0003122_maternal_imprinting0.71062717
87MP0003755_abnormal_palate_morphology0.69895917
88MP0000313_abnormal_cell_death0.69653550
89MP0002086_abnormal_extraembryonic_tissu0.69603624
90MP0005389_reproductive_system_phenotype0.69177559
91MP0006036_abnormal_mitochondrial_physio0.68677032
92MP0005253_abnormal_eye_physiology0.67625805
93MP0005391_vision/eye_phenotype0.67358257
94MP0005551_abnormal_eye_electrophysiolog0.67265032
95MP0000762_abnormal_tongue_morphology0.66795442
96MP0003137_abnormal_impulse_conducting0.66229086
97MP0004019_abnormal_vitamin_homeostasis0.63552513
98MP0001119_abnormal_female_reproductive0.61570240
99MP0003938_abnormal_ear_development0.61441318
100MP0000432_abnormal_head_morphology0.60286867

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.58685632
2Abnormality of the labia minora (HP:0012880)4.54034170
3Septo-optic dysplasia (HP:0100842)3.87398470
4Meckel diverticulum (HP:0002245)3.32713215
5Abnormal lung lobation (HP:0002101)3.29353229
6Abnormality of chromosome stability (HP:0003220)3.26670876
7Abnormality of the ileum (HP:0001549)3.21544260
8Chromsome breakage (HP:0040012)3.21350256
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13709405
10Nephroblastoma (Wilms tumor) (HP:0002667)3.08573463
11Birth length less than 3rd percentile (HP:0003561)3.01139247
12Pancreatic islet-cell hyperplasia (HP:0004510)2.94344152
13Multiple enchondromatosis (HP:0005701)2.90377797
14Embryonal renal neoplasm (HP:0011794)2.89676773
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.88060240
16Abnormality of the preputium (HP:0100587)2.75801378
17Bilateral microphthalmos (HP:0007633)2.74985866
18Chronic bronchitis (HP:0004469)2.63989499
19Ependymoma (HP:0002888)2.62980662
20Hypoglycemic seizures (HP:0002173)2.60168751
21Abnormality of serum amino acid levels (HP:0003112)2.57243740
22Hyperglycinemia (HP:0002154)2.52358024
23Abnormality of methionine metabolism (HP:0010901)2.52321350
24Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50015648
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48409247
26Hepatoblastoma (HP:0002884)2.46279803
27Small intestinal stenosis (HP:0012848)2.45649357
28Duodenal stenosis (HP:0100867)2.45649357
29Stenosis of the external auditory canal (HP:0000402)2.41007298
30Increased hepatocellular lipid droplets (HP:0006565)2.40903620
31Rhabdomyosarcoma (HP:0002859)2.39375886
32Lipid accumulation in hepatocytes (HP:0006561)2.36877840
33Facial cleft (HP:0002006)2.36228537
34Abnormality of the duodenum (HP:0002246)2.34727975
35Hyperinsulinemic hypoglycemia (HP:0000825)2.32173545
36Bifid tongue (HP:0010297)2.31504754
37Absent septum pellucidum (HP:0001331)2.30653309
38Optic nerve hypoplasia (HP:0000609)2.28751299
39Medulloblastoma (HP:0002885)2.28301711
40Volvulus (HP:0002580)2.27987591
41Abnormality of the septum pellucidum (HP:0007375)2.27299419
42Abnormality of homocysteine metabolism (HP:0010919)2.24004685
43Homocystinuria (HP:0002156)2.24004685
44Methylmalonic acidemia (HP:0002912)2.23150936
45Agnosia (HP:0010524)2.22708872
46Spastic diplegia (HP:0001264)2.19410659
47Maternal diabetes (HP:0009800)2.17889812
48Abnormal hair whorl (HP:0010721)2.17615588
49Choanal stenosis (HP:0000452)2.17317944
50Absent radius (HP:0003974)2.14648946
51Acute encephalopathy (HP:0006846)2.14239161
52Acute necrotizing encephalopathy (HP:0006965)2.12934319
53Absent eyebrow (HP:0002223)2.11751931
54Carpal bone hypoplasia (HP:0001498)2.11289074
55Abnormality of glycine metabolism (HP:0010895)2.10833427
56Abnormality of serine family amino acid metabolism (HP:0010894)2.10833427
57Triphalangeal thumb (HP:0001199)2.10784920
58Ectopic kidney (HP:0000086)2.08884247
59Biliary tract neoplasm (HP:0100574)2.07948114
60Breast aplasia (HP:0100783)2.06070467
61Esophageal atresia (HP:0002032)2.05432708
62Reduced antithrombin III activity (HP:0001976)2.05408738
63Megaloblastic anemia (HP:0001889)2.04137644
64Hyperglycinuria (HP:0003108)2.03993119
65Intestinal atresia (HP:0011100)2.01247220
66Sloping forehead (HP:0000340)2.01072575
67Sensory axonal neuropathy (HP:0003390)2.00199190
68Aplasia/Hypoplasia of the sternum (HP:0006714)1.99474902
69Absent forearm bone (HP:0003953)1.98214746
70Aplasia involving forearm bones (HP:0009822)1.98214746
71Neoplasm of the colon (HP:0100273)1.96339595
72Abolished electroretinogram (ERG) (HP:0000550)1.96088321
73Glioma (HP:0009733)1.95570743
74Cellular immunodeficiency (HP:0005374)1.95152204
75Supernumerary spleens (HP:0009799)1.95055120
76Anophthalmia (HP:0000528)1.94842927
77Aplasia/Hypoplasia of the breasts (HP:0010311)1.88709546
78Neoplasm of the adrenal gland (HP:0100631)1.88207263
79Abnormal number of incisors (HP:0011064)1.87689768
80Neoplasm of the adrenal cortex (HP:0100641)1.87655366
81Reticulocytopenia (HP:0001896)1.86016231
82Horseshoe kidney (HP:0000085)1.85284140
83Aplastic anemia (HP:0001915)1.84616289
84Gastrointestinal atresia (HP:0002589)1.82807333
85Symptomatic seizures (HP:0011145)1.80873461
86Selective tooth agenesis (HP:0001592)1.80337736
87Methylmalonic aciduria (HP:0012120)1.79942090
88Abnormality of the pancreatic islet cells (HP:0006476)1.79284741
89Abnormality of endocrine pancreas physiology (HP:0012093)1.79284741
90Absent thumb (HP:0009777)1.78955788
91Pendular nystagmus (HP:0012043)1.78090622
92Median cleft lip (HP:0000161)1.77827461
93Neoplasm of the oral cavity (HP:0100649)1.76435796
94Hypoplastic female external genitalia (HP:0012815)1.74927432
95Myelomeningocele (HP:0002475)1.74729592
96Oral leukoplakia (HP:0002745)1.74010147
97Cleft eyelid (HP:0000625)1.73800621
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73492434
99Abnormality of the clitoris (HP:0000056)1.73385788
100Clubbing of toes (HP:0100760)1.73071288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.16560516
2BUB13.77993373
3TNIK3.55310890
4ZAK3.47613554
5TTK3.21828041
6MKNK23.10545302
7PBK2.92162589
8TSSK62.66119333
9SRPK12.51770020
10WNK32.45551663
11PLK32.45430816
12MKNK12.39692730
13VRK22.28703112
14PLK42.24190847
15TAF12.23010220
16MST42.15934640
17PINK12.15738362
18NUAK12.09364490
19BMPR1B1.84585433
20VRK11.83408667
21ACVR1B1.83399422
22TRIM281.82858020
23BRSK21.72714986
24PLK11.71160609
25STK161.55962736
26EIF2AK31.45049045
27NEK11.42423143
28NME11.36579128
29DYRK21.31549690
30DYRK31.30964118
31STK38L1.26978624
32NEK21.25190831
33WEE11.25093864
34NLK1.19413120
35TLK11.09851004
36MARK31.08696168
37CSNK1G11.04322203
38ERBB41.01174453
39CASK1.00796864
40ATR0.99941207
41CHEK20.97155301
42ALK0.96863624
43GRK10.93125500
44ATM0.91842040
45AURKB0.88824469
46STK30.87915858
47LATS10.87672143
48CDK190.87633230
49PNCK0.84737763
50FGFR20.75178194
51STK40.74508730
52EIF2AK10.74311196
53OXSR10.74275960
54FGFR10.73716205
55CHEK10.71935952
56PDK20.70632944
57RPS6KA50.69985961
58CDK30.65384266
59BRSK10.64354807
60CSNK1G20.63211842
61MAP3K100.62902322
62TGFBR10.62273382
63TIE10.61816466
64CSNK1E0.57722328
65PLK20.56166137
66FRK0.52675643
67NME20.52468439
68CSNK1G30.52143488
69PRKCG0.51961101
70EIF2AK20.51418395
71PRKDC0.48974615
72PASK0.48949400
73CDK70.46531755
74CSNK2A20.46274131
75RPS6KA40.45749559
76CSNK2A10.45748779
77CDK10.45136972
78STK240.44550397
79BRAF0.43675906
80CSNK1A1L0.43101944
81BRD40.41005529
82CDK20.39573478
83CAMK1G0.39470474
84LATS20.38612482
85MAP3K90.37497676
86MELK0.36612282
87AURKA0.35272466
88CSNK1A10.34280263
89INSRR0.33503634
90MAP4K20.29124747
91OBSCN0.29082151
92MAP3K40.27552038
93BCR0.27185103
94FLT30.26146531
95PRKCE0.25795905
96SGK4940.24486537
97SGK2230.24486537
98PAK40.22776145
99MAP2K70.22368557
100EGFR0.22301280

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.59581429
2DNA replication_Homo sapiens_hsa030303.39212559
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.29837060
4Proteasome_Homo sapiens_hsa030503.17888489
5Non-homologous end-joining_Homo sapiens_hsa034503.03042446
6Homologous recombination_Homo sapiens_hsa034402.87441035
7RNA polymerase_Homo sapiens_hsa030202.80829101
8RNA transport_Homo sapiens_hsa030132.26737452
9Cysteine and methionine metabolism_Homo sapiens_hsa002702.11831894
10Spliceosome_Homo sapiens_hsa030402.04176015
11Ribosome_Homo sapiens_hsa030101.99777441
12RNA degradation_Homo sapiens_hsa030181.99677987
13Basal transcription factors_Homo sapiens_hsa030221.98761392
14Propanoate metabolism_Homo sapiens_hsa006401.92436945
15Fanconi anemia pathway_Homo sapiens_hsa034601.90890220
16One carbon pool by folate_Homo sapiens_hsa006701.90548684
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82926003
18Cell cycle_Homo sapiens_hsa041101.80291880
19Base excision repair_Homo sapiens_hsa034101.78468644
20Protein export_Homo sapiens_hsa030601.75473045
21Oxidative phosphorylation_Homo sapiens_hsa001901.73120850
22Vitamin B6 metabolism_Homo sapiens_hsa007501.71562551
23Parkinsons disease_Homo sapiens_hsa050121.69162306
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68115823
25Selenocompound metabolism_Homo sapiens_hsa004501.67028123
26Pyruvate metabolism_Homo sapiens_hsa006201.66360800
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66341188
28Nucleotide excision repair_Homo sapiens_hsa034201.57025053
29Vitamin digestion and absorption_Homo sapiens_hsa049771.47970789
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44998003
31mRNA surveillance pathway_Homo sapiens_hsa030151.37463375
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35727592
33Huntingtons disease_Homo sapiens_hsa050161.35423129
34Pyrimidine metabolism_Homo sapiens_hsa002401.35252810
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35233756
36Purine metabolism_Homo sapiens_hsa002301.26984447
37Steroid biosynthesis_Homo sapiens_hsa001001.24417495
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20374156
39Glutathione metabolism_Homo sapiens_hsa004801.16368656
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12698134
41Oocyte meiosis_Homo sapiens_hsa041141.07967748
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04701673
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01274798
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98352815
45Biosynthesis of amino acids_Homo sapiens_hsa012300.95789592
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93261820
47Alzheimers disease_Homo sapiens_hsa050100.92135072
48Hedgehog signaling pathway_Homo sapiens_hsa043400.92086069
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86259658
50Butanoate metabolism_Homo sapiens_hsa006500.84797546
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83119242
52Caffeine metabolism_Homo sapiens_hsa002320.82334886
53Systemic lupus erythematosus_Homo sapiens_hsa053220.81542080
54Carbon metabolism_Homo sapiens_hsa012000.78642425
55beta-Alanine metabolism_Homo sapiens_hsa004100.73039176
56Fatty acid elongation_Homo sapiens_hsa000620.71770396
57Wnt signaling pathway_Homo sapiens_hsa043100.71189778
58Fatty acid degradation_Homo sapiens_hsa000710.71025505
59Nitrogen metabolism_Homo sapiens_hsa009100.70402211
60Metabolic pathways_Homo sapiens_hsa011000.66790910
61Retinol metabolism_Homo sapiens_hsa008300.63950901
62Tryptophan metabolism_Homo sapiens_hsa003800.63445814
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62845918
64TGF-beta signaling pathway_Homo sapiens_hsa043500.61972414
65p53 signaling pathway_Homo sapiens_hsa041150.61856198
66Nicotine addiction_Homo sapiens_hsa050330.60670219
67Phototransduction_Homo sapiens_hsa047440.60581431
68Arginine and proline metabolism_Homo sapiens_hsa003300.58991139
69Cardiac muscle contraction_Homo sapiens_hsa042600.58903388
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57441196
71Tight junction_Homo sapiens_hsa045300.56642116
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56626531
73Peroxisome_Homo sapiens_hsa041460.55294449
74Basal cell carcinoma_Homo sapiens_hsa052170.54291541
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53396229
76Alcoholism_Homo sapiens_hsa050340.52783739
77Hippo signaling pathway_Homo sapiens_hsa043900.52623535
78Fat digestion and absorption_Homo sapiens_hsa049750.52076396
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51815763
80Folate biosynthesis_Homo sapiens_hsa007900.51724689
81Chemical carcinogenesis_Homo sapiens_hsa052040.50934938
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50615549
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49089472
84Fatty acid metabolism_Homo sapiens_hsa012120.46376777
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45582396
86Olfactory transduction_Homo sapiens_hsa047400.45489234
87Lysine degradation_Homo sapiens_hsa003100.44147331
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43567070
89Arginine biosynthesis_Homo sapiens_hsa002200.41884660
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41099141
91Taste transduction_Homo sapiens_hsa047420.36734249
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35073358
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34740757
94Adherens junction_Homo sapiens_hsa045200.32095035
95Thyroid cancer_Homo sapiens_hsa052160.31292862
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29504543
97Gap junction_Homo sapiens_hsa045400.29088555
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.28897756
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28324628
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26192843

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