ANKRD18A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)3.82525104
2centriole replication (GO:0007099)3.67083397
3regulation of mitotic spindle checkpoint (GO:1903504)3.54653997
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.54653997
5replication fork processing (GO:0031297)3.54424679
6regulation of centriole replication (GO:0046599)3.49015464
7mitotic sister chromatid cohesion (GO:0007064)3.45049931
8positive regulation of histone H3-K4 methylation (GO:0051571)3.44505715
9regulation of mitochondrial translation (GO:0070129)3.35691206
10establishment of protein localization to Golgi (GO:0072600)3.28617471
11kinetochore organization (GO:0051383)3.25903872
12double-strand break repair via homologous recombination (GO:0000724)3.17105421
13regulation of centrosome duplication (GO:0010824)3.15129415
14centriole assembly (GO:0098534)3.13832285
15recombinational repair (GO:0000725)3.10636378
16reciprocal DNA recombination (GO:0035825)3.10234950
17reciprocal meiotic recombination (GO:0007131)3.10234950
18endosome to melanosome transport (GO:0035646)3.09824675
19endosome to pigment granule transport (GO:0043485)3.09824675
20regulation of establishment of cell polarity (GO:2000114)3.06111860
21acrosome reaction (GO:0007340)3.04530452
22rRNA transcription (GO:0009303)3.04241379
23regulation of DNA endoreduplication (GO:0032875)3.00263908
24kinetochore assembly (GO:0051382)2.97878057
25maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.94071798
26regulation of centrosome cycle (GO:0046605)2.92873388
27positive regulation of developmental pigmentation (GO:0048087)2.92275241
28Leydig cell differentiation (GO:0033327)2.90408223
29resolution of meiotic recombination intermediates (GO:0000712)2.89777565
30snRNA transcription (GO:0009301)2.89225803
31auditory receptor cell differentiation (GO:0042491)2.87821029
32sister chromatid cohesion (GO:0007062)2.85472337
33centrosome organization (GO:0051297)2.85287400
34centrosome duplication (GO:0051298)2.80797775
35pseudouridine synthesis (GO:0001522)2.80398830
36regulation of histone H3-K4 methylation (GO:0051569)2.78104126
37DNA replication checkpoint (GO:0000076)2.77266073
38non-recombinational repair (GO:0000726)2.75936971
39double-strand break repair via nonhomologous end joining (GO:0006303)2.75936971
40regulation of spindle checkpoint (GO:0090231)2.75390770
41microtubule organizing center organization (GO:0031023)2.74667046
42synapsis (GO:0007129)2.74589796
43protein targeting to Golgi (GO:0000042)2.69777420
44transcription from mitochondrial promoter (GO:0006390)2.69272858
45positive regulation of mitotic sister chromatid separation (GO:1901970)2.67366341
46positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.67366341
47positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.67366341
48DNA double-strand break processing (GO:0000729)2.66685479
49chromosome organization involved in meiosis (GO:0070192)2.64785327
50regulation of establishment or maintenance of cell polarity (GO:0032878)2.64240097
51pteridine-containing compound biosynthetic process (GO:0042559)2.64185129
52regulation of cilium movement (GO:0003352)2.62833856
53male meiosis (GO:0007140)2.58408357
54cellular ketone body metabolic process (GO:0046950)2.57716783
55TOR signaling (GO:0031929)2.55686019
56DNA methylation involved in gamete generation (GO:0043046)2.53496607
57retrograde transport, vesicle recycling within Golgi (GO:0000301)2.53116317
58negative regulation of DNA-dependent DNA replication (GO:2000104)2.51784050
59histone exchange (GO:0043486)2.50523410
60telomere maintenance via telomerase (GO:0007004)2.48930282
61Golgi to endosome transport (GO:0006895)2.48696382
62maturation of 5.8S rRNA (GO:0000460)2.48480254
63mitochondrial respiratory chain complex assembly (GO:0033108)2.46686657
64negative regulation of multicellular organism growth (GO:0040015)2.44835300
65protein complex biogenesis (GO:0070271)2.43189017
66signal peptide processing (GO:0006465)2.42957381
67cilium or flagellum-dependent cell motility (GO:0001539)2.42677684
68sperm motility (GO:0030317)2.42560207
69negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.40156537
70negative regulation of translation, ncRNA-mediated (GO:0040033)2.40156537
71regulation of translation, ncRNA-mediated (GO:0045974)2.40156537
72ncRNA catabolic process (GO:0034661)2.38664854
73axoneme assembly (GO:0035082)2.38623322
74otic vesicle formation (GO:0030916)2.38379735
75L-fucose catabolic process (GO:0042355)2.37558192
76fucose catabolic process (GO:0019317)2.37558192
77L-fucose metabolic process (GO:0042354)2.37558192
78intraciliary transport (GO:0042073)2.37321335
79DNA synthesis involved in DNA repair (GO:0000731)2.35752976
80disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.35113541
81killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.35113541
82telomere maintenance via recombination (GO:0000722)2.34801686
83histone-serine phosphorylation (GO:0035404)2.34197385
84cilium movement (GO:0003341)2.33527855
85rRNA catabolic process (GO:0016075)2.32784321
86chromatin remodeling at centromere (GO:0031055)2.32363716
87mRNA cleavage (GO:0006379)2.32192716
88ketone body metabolic process (GO:1902224)2.31981703
89epithelial cilium movement (GO:0003351)2.31546718
90negative regulation of translational initiation (GO:0045947)2.31493607
91cytochrome complex assembly (GO:0017004)2.31363820
92ribosomal small subunit biogenesis (GO:0042274)2.30775524
93nephron tubule morphogenesis (GO:0072078)2.28558510
94nephron epithelium morphogenesis (GO:0072088)2.28558510
95respiratory chain complex IV assembly (GO:0008535)2.28085923
96piRNA metabolic process (GO:0034587)2.27435806
97regulation of acrosome reaction (GO:0060046)2.27216941
98DNA replication initiation (GO:0006270)2.26563149
99monoubiquitinated protein deubiquitination (GO:0035520)2.26266110
100double-strand break repair (GO:0006302)2.26211124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.72831280
2E2F7_22180533_ChIP-Seq_HELA_Human4.84222863
3VDR_22108803_ChIP-Seq_LS180_Human3.08899212
4IGF1R_20145208_ChIP-Seq_DFB_Human3.04080434
5FUS_26573619_Chip-Seq_HEK293_Human2.79753269
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.50671597
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47777087
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45783407
9EWS_26573619_Chip-Seq_HEK293_Human2.44658902
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35301407
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26577767
12ER_23166858_ChIP-Seq_MCF-7_Human2.22314689
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.16486534
14GBX2_23144817_ChIP-Seq_PC3_Human2.12812815
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90076874
16E2F1_21310950_ChIP-Seq_MCF-7_Human1.86625093
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85021835
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84888919
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78525299
20FOXM1_23109430_ChIP-Seq_U2OS_Human1.76789501
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76771546
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69103722
23ZNF274_21170338_ChIP-Seq_K562_Hela1.66378193
24TAF15_26573619_Chip-Seq_HEK293_Human1.66193357
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63386316
26P300_19829295_ChIP-Seq_ESCs_Human1.62906411
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62052554
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.57847946
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57739545
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57608846
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57484065
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57478870
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56555625
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.56374642
35STAT3_23295773_ChIP-Seq_U87_Human1.56218068
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54807957
37MYC_18940864_ChIP-ChIP_HL60_Human1.54160548
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53678472
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.53380370
40ELK1_19687146_ChIP-ChIP_HELA_Human1.47448204
41TCF4_23295773_ChIP-Seq_U87_Human1.45648695
42AR_21572438_ChIP-Seq_LNCaP_Human1.42276315
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41315222
44CBP_20019798_ChIP-Seq_JUKART_Human1.41315222
45AR_21909140_ChIP-Seq_LNCAP_Human1.39411073
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38419677
47KDM5A_27292631_Chip-Seq_BREAST_Human1.36489357
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36121372
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35169427
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34887406
51POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34887406
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.32784345
53SMAD4_21799915_ChIP-Seq_A2780_Human1.32099810
54TP53_22573176_ChIP-Seq_HFKS_Human1.31888460
55KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30787982
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28846956
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.27652138
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27056549
59TCF4_22108803_ChIP-Seq_LS180_Human1.25610215
60VDR_23849224_ChIP-Seq_CD4+_Human1.24171403
61MYC_18555785_ChIP-Seq_MESCs_Mouse1.24004483
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21158968
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20772001
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17146465
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16631844
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.16035634
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.15263406
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.15159646
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15057905
70BCAT_22108803_ChIP-Seq_LS180_Human1.12113679
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10818942
72FOXP3_21729870_ChIP-Seq_TREG_Human1.09819262
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08790815
74TP53_16413492_ChIP-PET_HCT116_Human1.08243755
75AR_25329375_ChIP-Seq_VCAP_Human1.07605380
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06981421
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06529322
78RUNX2_22187159_ChIP-Seq_PCA_Human1.04056343
79AHR_22903824_ChIP-Seq_MCF-7_Human1.03075090
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02254823
81PHF8_20622853_ChIP-Seq_HELA_Human1.02204419
82NFYB_21822215_ChIP-Seq_K562_Human1.01498111
83ARNT_22903824_ChIP-Seq_MCF-7_Human0.98979501
84TBL1_22424771_ChIP-Seq_293T_Human0.98370274
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98137024
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.98137024
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97721588
88SOX2_19829295_ChIP-Seq_ESCs_Human0.97409294
89NANOG_19829295_ChIP-Seq_ESCs_Human0.97409294
90HOXB7_26014856_ChIP-Seq_BT474_Human0.96829158
91IRF1_19129219_ChIP-ChIP_H3396_Human0.96644401
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96561103
93CDX2_22108803_ChIP-Seq_LS180_Human0.96514260
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95316276
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95305710
96PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.95117371
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94640574
98FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94623004
99ETV1_20927104_ChIP-Seq_GIST48_Human0.93626452
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92244357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.07912706
2MP0010094_abnormal_chromosome_stability2.92470889
3MP0008877_abnormal_DNA_methylation2.63436999
4MP0003786_premature_aging2.63217827
5MP0002160_abnormal_reproductive_system2.46405793
6MP0008058_abnormal_DNA_repair2.39756538
7MP0003195_calcinosis2.39301083
8MP0003787_abnormal_imprinting1.91305059
9MP0001188_hyperpigmentation1.87692208
10MP0003123_paternal_imprinting1.85970486
11MP0009697_abnormal_copulation1.83956198
12MP0003136_yellow_coat_color1.81695786
13MP0002938_white_spotting1.80508888
14MP0000427_abnormal_hair_cycle1.77108283
15MP0009780_abnormal_chondrocyte_physiolo1.72123692
16MP0002837_dystrophic_cardiac_calcinosis1.71574582
17MP0003111_abnormal_nucleus_morphology1.69504274
18MP0009046_muscle_twitch1.66279348
19MP0006292_abnormal_olfactory_placode1.61332752
20MP0000569_abnormal_digit_pigmentation1.59568136
21MP0008007_abnormal_cellular_replicative1.56572548
22MP0005551_abnormal_eye_electrophysiolog1.55771473
23MP0000631_abnormal_neuroendocrine_gland1.55085055
24MP0003077_abnormal_cell_cycle1.53847115
25MP0010678_abnormal_skin_adnexa1.52775021
26MP0003693_abnormal_embryo_hatching1.52681239
27MP0004043_abnormal_pH_regulation1.51701956
28MP0005174_abnormal_tail_pigmentation1.48092099
29MP0005410_abnormal_fertilization1.44174961
30MP0003121_genomic_imprinting1.43631076
31MP0001929_abnormal_gametogenesis1.42913394
32MP0000383_abnormal_hair_follicle1.41874597
33MP0003718_maternal_effect1.36146558
34MP0010234_abnormal_vibrissa_follicle1.33459695
35MP0001984_abnormal_olfaction1.31863935
36MP0002095_abnormal_skin_pigmentation1.29322338
37MP0003950_abnormal_plasma_membrane1.28525342
38MP0003698_abnormal_male_reproductive1.27536004
39MP0006072_abnormal_retinal_apoptosis1.26910164
40MP0004957_abnormal_blastocyst_morpholog1.26068899
41MP0010386_abnormal_urinary_bladder1.23980517
42MP0005389_reproductive_system_phenotype1.23806298
43MP0003937_abnormal_limbs/digits/tail_de1.22790840
44MP0002210_abnormal_sex_determination1.22565946
45MP0001944_abnormal_pancreas_morphology1.21500043
46MP0004147_increased_porphyrin_level1.19619130
47MP0001145_abnormal_male_reproductive1.17977875
48MP0005220_abnormal_exocrine_pancreas1.14414317
49MP0004019_abnormal_vitamin_homeostasis1.13454168
50MP0005646_abnormal_pituitary_gland1.10306983
51MP0005266_abnormal_metabolism1.09532793
52MP0004215_abnormal_myocardial_fiber1.08967541
53MP0002876_abnormal_thyroid_physiology1.08401655
54MP0003890_abnormal_embryonic-extraembry1.05005683
55MP0000653_abnormal_sex_gland1.04916799
56MP0010307_abnormal_tumor_latency1.04841634
57MP0005379_endocrine/exocrine_gland_phen1.04581571
58MP0000015_abnormal_ear_pigmentation1.00881175
59MP0005075_abnormal_melanosome_morpholog1.00159372
60MP0001764_abnormal_homeostasis0.99368221
61MP0006036_abnormal_mitochondrial_physio0.99295799
62MP0002928_abnormal_bile_duct0.97816235
63MP0003252_abnormal_bile_duct0.97605194
64MP0002693_abnormal_pancreas_physiology0.95710890
65MP0002638_abnormal_pupillary_reflex0.94453147
66MP0008961_abnormal_basal_metabolism0.94272787
67MP0000013_abnormal_adipose_tissue0.93599874
68MP0003186_abnormal_redox_activity0.92880480
69MP0008995_early_reproductive_senescence0.89877607
70MP0005395_other_phenotype0.89374201
71MP0006035_abnormal_mitochondrial_morpho0.86330501
72MP0000538_abnormal_urinary_bladder0.86042106
73MP0005623_abnormal_meninges_morphology0.85245286
74MP0003137_abnormal_impulse_conducting0.85052382
75MP0002177_abnormal_outer_ear0.84666982
76MP0001485_abnormal_pinna_reflex0.84312200
77MP0001968_abnormal_touch/_nociception0.84238734
78MP0002163_abnormal_gland_morphology0.83443564
79MP0005332_abnormal_amino_acid0.82250888
80MP0003385_abnormal_body_wall0.79867493
81MP0003941_abnormal_skin_development0.79608380
82MP0005253_abnormal_eye_physiology0.79293842
83MP0002233_abnormal_nose_morphology0.77391265
84MP0001486_abnormal_startle_reflex0.76908337
85MP0005408_hypopigmentation0.75875203
86MP0004197_abnormal_fetal_growth/weight/0.71647429
87MP0002161_abnormal_fertility/fecundity0.70268529
88MP0001697_abnormal_embryo_size0.68999648
89MP0009703_decreased_birth_body0.67118892
90MP0004134_abnormal_chest_morphology0.66860891
91MP0002168_other_aberrant_phenotype0.66138154
92MP0001765_abnormal_ion_homeostasis0.65641016
93MP0004085_abnormal_heartbeat0.64774384
94MP0008932_abnormal_embryonic_tissue0.64701718
95MP0001299_abnormal_eye_distance/0.63973868
96MP0002970_abnormal_white_adipose0.63597947
97MP0002078_abnormal_glucose_homeostasis0.63377588
98MP0003943_abnormal_hepatobiliary_system0.63228248
99MP0005376_homeostasis/metabolism_phenot0.62096003
100MP0001529_abnormal_vocalization0.61877172

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)5.16071756
2Volvulus (HP:0002580)4.61968210
3Chromsome breakage (HP:0040012)4.51139440
4Hypoplasia of the pons (HP:0012110)4.26999503
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09607457
6Abnormality of the pons (HP:0007361)4.00752705
7Type II lissencephaly (HP:0007260)3.98810628
8Retinal atrophy (HP:0001105)3.68544228
9Molar tooth sign on MRI (HP:0002419)3.16645555
10Abnormality of midbrain morphology (HP:0002418)3.16645555
11Pancreatic cysts (HP:0001737)3.13475440
12Nephronophthisis (HP:0000090)2.92690122
13Abnormality of the renal cortex (HP:0011035)2.88539753
14Pancreatic fibrosis (HP:0100732)2.85417497
15Abnormality of chromosome stability (HP:0003220)2.79431245
16Medial flaring of the eyebrow (HP:0010747)2.74493020
17Abnormality of the renal medulla (HP:0100957)2.72259201
18Tubulointerstitial nephritis (HP:0001970)2.71879535
19Tubular atrophy (HP:0000092)2.65964441
20Chronic hepatic failure (HP:0100626)2.59640780
21Urethral obstruction (HP:0000796)2.57313453
22True hermaphroditism (HP:0010459)2.45636355
23Vascular calcification (HP:0004934)2.41176704
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34673941
25Abnormality of the ileum (HP:0001549)2.31514974
26Abnormality of DNA repair (HP:0003254)2.30305281
27Abnormality of renal resorption (HP:0011038)2.28568945
28Ectopic kidney (HP:0000086)2.28089610
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.27577646
30Cystic liver disease (HP:0006706)2.26315068
31Abnormality of the preputium (HP:0100587)2.19603483
32Meckel diverticulum (HP:0002245)2.18151905
33Reticulocytopenia (HP:0001896)2.17412503
34Sloping forehead (HP:0000340)2.11433100
35Protruding tongue (HP:0010808)2.11422724
36Aplasia/Hypoplasia affecting the retina (HP:0008061)2.11232603
37Polydipsia (HP:0001959)2.06066170
38Abnormal drinking behavior (HP:0030082)2.06066170
39Abnormality of renal excretion (HP:0011036)2.05664236
40Retinal dysplasia (HP:0007973)2.05125408
41Large for gestational age (HP:0001520)2.02808380
42Median cleft lip (HP:0000161)2.01385182
43Abnormality of the labia minora (HP:0012880)2.00629931
44Pancreatic islet-cell hyperplasia (HP:0004510)2.00365570
45Acute necrotizing encephalopathy (HP:0006965)1.94469915
46Birth length less than 3rd percentile (HP:0003561)1.94202529
47Male pseudohermaphroditism (HP:0000037)1.93558280
48Absent thumb (HP:0009777)1.91949765
49Gaze-evoked nystagmus (HP:0000640)1.91302627
50Papillary thyroid carcinoma (HP:0002895)1.88872059
51Hyperphosphatemia (HP:0002905)1.88466247
52Buphthalmos (HP:0000557)1.85505916
53Preaxial hand polydactyly (HP:0001177)1.83325343
54Absent radius (HP:0003974)1.81654212
55Cardiovascular calcification (HP:0011915)1.81585048
56Sensory axonal neuropathy (HP:0003390)1.81089034
57Enlarged kidneys (HP:0000105)1.80825309
58Prominent nasal bridge (HP:0000426)1.80524692
59Clubbing of toes (HP:0100760)1.79920342
60Abnormality of permanent molar morphology (HP:0011071)1.79177959
61Abnormality of the dental root (HP:0006486)1.79177959
62Taurodontia (HP:0000679)1.79177959
63Abnormal protein glycosylation (HP:0012346)1.79110072
64Abnormal glycosylation (HP:0012345)1.79110072
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79110072
66Abnormal protein N-linked glycosylation (HP:0012347)1.79110072
67Impulsivity (HP:0100710)1.79034189
68Septate vagina (HP:0001153)1.77582206
69Poikiloderma (HP:0001029)1.77157467
70Abolished electroretinogram (ERG) (HP:0000550)1.77154376
71Congenital primary aphakia (HP:0007707)1.76371106
72Progressive macrocephaly (HP:0004481)1.74364458
73Abnormality of aromatic amino acid family metabolism (HP:0004338)1.73475874
74Abnormality of endocrine pancreas physiology (HP:0012093)1.73069543
75Abnormality of the pancreatic islet cells (HP:0006476)1.73069543
76Neoplasm of the oral cavity (HP:0100649)1.71640065
77Fatigue (HP:0012378)1.71316608
78Nephrogenic diabetes insipidus (HP:0009806)1.70178622
79Metaphyseal dysplasia (HP:0100255)1.69479970
80Type I transferrin isoform profile (HP:0003642)1.68208421
81Poor coordination (HP:0002370)1.67615861
82Gait imbalance (HP:0002141)1.66677914
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.66549371
84Abnormality of cochlea (HP:0000375)1.66375979
85Congenital hepatic fibrosis (HP:0002612)1.65629437
86Absent forearm bone (HP:0003953)1.65058835
87Aplasia involving forearm bones (HP:0009822)1.65058835
88Mitochondrial inheritance (HP:0001427)1.64330894
89Hyperinsulinemic hypoglycemia (HP:0000825)1.63923573
90Highly arched eyebrow (HP:0002553)1.62552577
91Genital tract atresia (HP:0001827)1.61965914
92Hypoplastic labia majora (HP:0000059)1.60294148
93Severe muscular hypotonia (HP:0006829)1.60199833
94Duplicated collecting system (HP:0000081)1.59024429
95Tubulointerstitial abnormality (HP:0001969)1.56963864
96Intestinal atresia (HP:0011100)1.56759402
97Nephroblastoma (Wilms tumor) (HP:0002667)1.56448106
98Small intestinal stenosis (HP:0012848)1.56139386
99Duodenal stenosis (HP:0100867)1.56139386
100Acute encephalopathy (HP:0006846)1.55613719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.47431979
2MARK32.99596721
3PNCK2.65030578
4MST42.58658925
5CDC72.41706076
6MST1R2.32238791
7NUAK12.28685072
8CASK2.27775378
9WNK42.23751191
10TNIK2.05793180
11STK391.98673875
12LATS11.95580616
13MKNK21.91501293
14BMPR1B1.88483862
15PIK3CA1.73335498
16STK101.69433504
17PINK11.63784347
18BRSK21.63142838
19ACVR1B1.48639559
20FGFR21.41546087
21PIK3CG1.38748873
22STK38L1.35454508
23PTK2B1.35253640
24PLK41.34893410
25BUB11.34133896
26SRPK11.34087395
27STK31.29431104
28CDK121.28463090
29CAMK1G1.25187782
30ZAK1.18038827
31NME11.15892207
32TRPM71.15037090
33RPS6KB21.13973324
34PBK1.13511164
35MKNK11.12381179
36TTK1.11331457
37CDK31.05444341
38EIF2AK31.02309578
39PLK11.02101583
40WNK31.00891519
41NEK21.00129066
42TNK20.99820469
43CHEK20.98416574
44GRK10.97154456
45NLK0.95831894
46ATM0.95506127
47MAP3K40.93979315
48MAP3K90.93441107
49CHEK10.91888011
50NTRK30.89273568
51TRIM280.88857054
52MAP4K20.88589156
53OXSR10.87060941
54CSNK1E0.86356080
55ATR0.85257439
56WNK10.84306845
57TLK10.83935664
58EIF2AK10.80828765
59MAP3K20.79661534
60MAP2K70.78912762
61STK110.77674319
62MET0.77117814
63PLK30.76571794
64AURKB0.74043790
65DMPK0.72374109
66BRD40.69215127
67WEE10.68155732
68VRK10.67013487
69CSNK1G10.65585725
70RPS6KA50.65152213
71AKT30.64065106
72INSRR0.63550459
73MAP2K60.61861604
74CDK10.61314562
75CSNK2A20.57577896
76PAK30.56257855
77TAF10.56252130
78CAMK2D0.55081551
79MAPK130.54763463
80TEC0.52940973
81CSNK1D0.52314579
82MAPK140.49473739
83MUSK0.49415748
84CSNK1A10.49279920
85BRSK10.48904625
86PRKCI0.48166730
87MTOR0.46866940
88CDK20.46329922
89MAPKAPK50.44924119
90GSK3B0.42518833
91PRKCE0.41898966
92PRKDC0.41664865
93SGK10.41554502
94STK40.41446572
95OBSCN0.40547901
96CAMK10.39869969
97CSNK1A1L0.38577247
98LMTK20.38231473
99FGFR10.37805163
100PRKAA20.35575828

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.65958210
2Fanconi anemia pathway_Homo sapiens_hsa034602.85273169
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62171895
4DNA replication_Homo sapiens_hsa030302.58628689
5Mismatch repair_Homo sapiens_hsa034302.53347647
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.48495231
7RNA polymerase_Homo sapiens_hsa030202.29764211
8Non-homologous end-joining_Homo sapiens_hsa034502.14957625
9Protein export_Homo sapiens_hsa030602.01221509
10One carbon pool by folate_Homo sapiens_hsa006701.89947997
11Basal transcription factors_Homo sapiens_hsa030221.86864991
12Butanoate metabolism_Homo sapiens_hsa006501.84591166
13Ribosome_Homo sapiens_hsa030101.74344233
14Folate biosynthesis_Homo sapiens_hsa007901.70859876
15Nucleotide excision repair_Homo sapiens_hsa034201.68535247
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63672085
17RNA transport_Homo sapiens_hsa030131.59963969
18Oxidative phosphorylation_Homo sapiens_hsa001901.53413514
19RNA degradation_Homo sapiens_hsa030181.52075197
20Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48810847
21Base excision repair_Homo sapiens_hsa034101.45025693
22Propanoate metabolism_Homo sapiens_hsa006401.43014672
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42092241
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40213538
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38613530
26Pyrimidine metabolism_Homo sapiens_hsa002401.38486831
27Huntingtons disease_Homo sapiens_hsa050161.28882722
28Ether lipid metabolism_Homo sapiens_hsa005651.28723524
29Nitrogen metabolism_Homo sapiens_hsa009101.26986718
30Lysine degradation_Homo sapiens_hsa003101.24945680
31Purine metabolism_Homo sapiens_hsa002301.17774794
32Insulin secretion_Homo sapiens_hsa049111.16389019
33Selenocompound metabolism_Homo sapiens_hsa004501.08726419
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08499099
35ABC transporters_Homo sapiens_hsa020101.04972621
36Oocyte meiosis_Homo sapiens_hsa041141.04867094
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.03743446
38mRNA surveillance pathway_Homo sapiens_hsa030151.02621920
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01599270
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98617363
41Phototransduction_Homo sapiens_hsa047440.98203711
42Olfactory transduction_Homo sapiens_hsa047400.97434260
43Spliceosome_Homo sapiens_hsa030400.97019389
44Parkinsons disease_Homo sapiens_hsa050120.95990583
45beta-Alanine metabolism_Homo sapiens_hsa004100.95611512
46Taste transduction_Homo sapiens_hsa047420.92375852
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90520392
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89007115
49Linoleic acid metabolism_Homo sapiens_hsa005910.88954903
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85318660
51Sulfur metabolism_Homo sapiens_hsa009200.81197491
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.80975372
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.79600788
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78630390
55Circadian rhythm_Homo sapiens_hsa047100.76735776
56Glycerolipid metabolism_Homo sapiens_hsa005610.76109218
57Cell cycle_Homo sapiens_hsa041100.75353576
58Metabolic pathways_Homo sapiens_hsa011000.74636610
59Peroxisome_Homo sapiens_hsa041460.72868886
60Alzheimers disease_Homo sapiens_hsa050100.72617561
61Regulation of autophagy_Homo sapiens_hsa041400.72602331
62Sphingolipid metabolism_Homo sapiens_hsa006000.72217357
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69921043
64Vitamin B6 metabolism_Homo sapiens_hsa007500.69629524
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69562741
66Tryptophan metabolism_Homo sapiens_hsa003800.69462779
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69208777
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68817726
69Pancreatic secretion_Homo sapiens_hsa049720.68435952
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68412218
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64618435
72Chemical carcinogenesis_Homo sapiens_hsa052040.63190996
73N-Glycan biosynthesis_Homo sapiens_hsa005100.62907613
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58714118
75Mineral absorption_Homo sapiens_hsa049780.58305326
76Retinol metabolism_Homo sapiens_hsa008300.57572268
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57528196
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54878586
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53896243
80Fatty acid degradation_Homo sapiens_hsa000710.53657954
81Glutathione metabolism_Homo sapiens_hsa004800.52945491
82Type II diabetes mellitus_Homo sapiens_hsa049300.51796664
83Fatty acid metabolism_Homo sapiens_hsa012120.51763159
84Nicotine addiction_Homo sapiens_hsa050330.51177590
85Starch and sucrose metabolism_Homo sapiens_hsa005000.49818941
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49430884
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48389287
88Vitamin digestion and absorption_Homo sapiens_hsa049770.47120083
89Cardiac muscle contraction_Homo sapiens_hsa042600.46887688
90Histidine metabolism_Homo sapiens_hsa003400.45443018
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44797935
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44144052
93Salivary secretion_Homo sapiens_hsa049700.42775577
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41716368
95Sulfur relay system_Homo sapiens_hsa041220.40894440
96Renin-angiotensin system_Homo sapiens_hsa046140.39745053
97TGF-beta signaling pathway_Homo sapiens_hsa043500.39486003
98Tight junction_Homo sapiens_hsa045300.38220974
99Arginine biosynthesis_Homo sapiens_hsa002200.37509079
100Melanoma_Homo sapiens_hsa052180.36721840

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