ANKRD17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.66165439
2nuclear pore organization (GO:0006999)5.37596588
3mitotic sister chromatid cohesion (GO:0007064)5.25740630
4cytoplasmic mRNA processing body assembly (GO:0033962)4.41016478
5histone H3-K4 trimethylation (GO:0080182)4.19018496
6pore complex assembly (GO:0046931)4.10398180
7regulation of RNA export from nucleus (GO:0046831)4.09067176
8pre-miRNA processing (GO:0031054)4.02841640
9regulation of NFAT protein import into nucleus (GO:0051532)3.94851903
10embryonic retina morphogenesis in camera-type eye (GO:0060059)3.87504428
11regulation of DNA endoreduplication (GO:0032875)3.69653107
12sister chromatid cohesion (GO:0007062)3.57864314
13regulation of spindle organization (GO:0090224)3.55312674
14histone H3-K4 methylation (GO:0051568)3.53766604
15positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.51803404
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.49134813
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49134813
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49134813
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.48211945
20peptidyl-lysine trimethylation (GO:0018023)3.40977042
21regulation of nucleobase-containing compound transport (GO:0032239)3.40794451
22DNA unwinding involved in DNA replication (GO:0006268)3.36693186
23paraxial mesoderm development (GO:0048339)3.30424733
24NLS-bearing protein import into nucleus (GO:0006607)3.26864471
25histone H3-K9 methylation (GO:0051567)3.26492600
26negative regulation of histone methylation (GO:0031061)3.26314868
27interkinetic nuclear migration (GO:0022027)3.23222435
28mitotic chromosome condensation (GO:0007076)3.22433942
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.21465892
30regulation of translation, ncRNA-mediated (GO:0045974)3.21465892
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21465892
32monoubiquitinated protein deubiquitination (GO:0035520)3.19980628
33response to UV-C (GO:0010225)3.19831769
34glucocorticoid receptor signaling pathway (GO:0042921)3.18737946
35kinetochore organization (GO:0051383)3.17731623
36regulation of mitotic spindle organization (GO:0060236)3.13884873
37negative regulation of DNA repair (GO:0045738)3.13016004
38histone lysine methylation (GO:0034968)3.06837423
39embryonic camera-type eye morphogenesis (GO:0048596)3.04933056
40meiotic chromosome segregation (GO:0045132)3.01582130
41histone H3-K36 demethylation (GO:0070544)2.98281625
42corticosteroid receptor signaling pathway (GO:0031958)2.89359933
43protein localization to microtubule (GO:0035372)2.83101294
44regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.82437496
45mitotic nuclear envelope disassembly (GO:0007077)2.80939510
46regulation of histone H3-K9 methylation (GO:0051570)2.78572808
47regulation of histone H3-K4 methylation (GO:0051569)2.77885868
48negative regulation of potassium ion transmembrane transport (GO:1901380)2.77440361
49regulation of sister chromatid cohesion (GO:0007063)2.74942986
50morphogenesis of an epithelial sheet (GO:0002011)2.73548383
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.72417154
52positive regulation of chromosome segregation (GO:0051984)2.71966171
53histone lysine demethylation (GO:0070076)2.71662932
54peptidyl-threonine phosphorylation (GO:0018107)2.71646879
55membrane disassembly (GO:0030397)2.71593152
56nuclear envelope disassembly (GO:0051081)2.71593152
57histone demethylation (GO:0016577)2.70917798
58histone H3-K9 modification (GO:0061647)2.70553331
59histone H2A monoubiquitination (GO:0035518)2.70325128
60protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.70254079
61sister chromatid segregation (GO:0000819)2.70073877
62negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.68903392
63gene silencing by RNA (GO:0031047)2.68038687
64peptidyl-lysine methylation (GO:0018022)2.67657079
65regulation of protein polyubiquitination (GO:1902914)2.67001468
66COPII vesicle coating (GO:0048208)2.66893429
67kinetochore assembly (GO:0051382)2.65891613
68regulation of histone methylation (GO:0031060)2.65658842
69hippo signaling (GO:0035329)2.65530285
70regulation of centriole replication (GO:0046599)2.63986067
71histone H4-K12 acetylation (GO:0043983)2.63692512
72protein K6-linked ubiquitination (GO:0085020)2.62516087
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.61403824
74regulation of meiosis I (GO:0060631)2.60086577
75peptidyl-threonine modification (GO:0018210)2.59719780
76histone H4-K16 acetylation (GO:0043984)2.58087433
77DNA synthesis involved in DNA repair (GO:0000731)2.57860419
78piRNA metabolic process (GO:0034587)2.57638144
79establishment of nucleus localization (GO:0040023)2.57021597
80histone methylation (GO:0016571)2.56897207
81DNA alkylation (GO:0006305)2.56223872
82DNA methylation (GO:0006306)2.56223872
83heterochromatin organization (GO:0070828)2.55695756
84positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.55002881
85regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.55002881
86negative regulation of neurotransmitter secretion (GO:0046929)2.54583189
87regulation of histone H3-K27 methylation (GO:0061085)2.54041819
88regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52715089
89positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52715089
90mitotic metaphase plate congression (GO:0007080)2.52188072
91phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.51326151
92histone H4-K8 acetylation (GO:0043982)2.49838718
93histone H4-K5 acetylation (GO:0043981)2.49838718
94nucleus localization (GO:0051647)2.49277215
95protein export from nucleus (GO:0006611)2.47563214
96histone mRNA catabolic process (GO:0071044)2.47413983
97metaphase plate congression (GO:0051310)2.46423580
98embryonic eye morphogenesis (GO:0048048)2.45966311
99cytoskeletal anchoring at plasma membrane (GO:0007016)2.45711190
100reciprocal meiotic recombination (GO:0007131)2.44146127
101reciprocal DNA recombination (GO:0035825)2.44146127
102positive regulation of cell cycle checkpoint (GO:1901978)2.42028567
103attachment of spindle microtubules to kinetochore (GO:0008608)2.41951803
104RNA stabilization (GO:0043489)2.41776965
105mRNA stabilization (GO:0048255)2.41776965
106negative regulation of histone modification (GO:0031057)2.41685531
107establishment of spindle orientation (GO:0051294)2.41193675
108coronary vasculature morphogenesis (GO:0060977)2.41190665
109DNA geometric change (GO:0032392)2.40488132
110protein dealkylation (GO:0008214)2.40067600
111protein demethylation (GO:0006482)2.40067600
112artery development (GO:0060840)2.39722353
113regulation of centrosome duplication (GO:0010824)2.39619276
114nucleus organization (GO:0006997)2.39224269
115genitalia morphogenesis (GO:0035112)2.38078612
116apical protein localization (GO:0045176)2.37036412
117protein-DNA complex disassembly (GO:0032986)2.36528772
118nucleosome disassembly (GO:0006337)2.36528772
119chromatin assembly (GO:0031497)2.36280101
120DNA duplex unwinding (GO:0032508)2.36235816
121mitotic sister chromatid segregation (GO:0000070)2.35692028
122DNA damage induced protein phosphorylation (GO:0006975)2.35131893
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.34775652
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.32248696
125histone H3-K9 demethylation (GO:0033169)2.32139985
126stress granule assembly (GO:0034063)2.31742926
127N-terminal protein amino acid acetylation (GO:0006474)2.31495583
128establishment of spindle localization (GO:0051293)2.30849183
129negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.30532789
130heart morphogenesis (GO:0003007)2.30205430
131spindle checkpoint (GO:0031577)2.29724780
132peptidyl-lysine dimethylation (GO:0018027)2.28564950
133regulation of mitotic sister chromatid segregation (GO:0033047)2.28239124
134regulation of sister chromatid segregation (GO:0033045)2.28239124
135regulation of mitotic sister chromatid separation (GO:0010965)2.28239124
136negative regulation of chromatin modification (GO:1903309)2.27728898
137protein K48-linked deubiquitination (GO:0071108)2.27197033
138protein localization to microtubule cytoskeleton (GO:0072698)2.26927070
139histone H2B ubiquitination (GO:0033523)2.26281182
140spliceosomal tri-snRNP complex assembly (GO:0000244)2.26225417
141branching involved in prostate gland morphogenesis (GO:0060442)2.26055071
142DNA topological change (GO:0006265)2.24693710
143nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.24090893
144hemidesmosome assembly (GO:0031581)2.23548625
145dosage compensation (GO:0007549)2.22255561
146positive regulation of gene expression, epigenetic (GO:0045815)2.21755879
147regulation of transforming growth factor beta2 production (GO:0032909)2.21702237
148positive regulation of catenin import into nucleus (GO:0035413)2.21681701
149gastrulation with mouth forming second (GO:0001702)2.20781229
150regulation of translational fidelity (GO:0006450)2.18517492
151Golgi to endosome transport (GO:0006895)2.18259891
152regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.18233242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.32541022
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.77406351
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.95700692
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.70943558
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.41044354
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.85196592
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.82317065
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72388715
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.67235448
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52187849
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48756793
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34558238
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.15244982
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.09853038
15FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.92323438
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91738604
17* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.91107321
18* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90769328
19TP53_16413492_ChIP-PET_HCT116_Human1.87536963
20* E2F1_21310950_ChIP-Seq_MCF-7_Human1.82207436
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79513835
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62115587
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61181680
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60757580
25EZH2_22144423_ChIP-Seq_EOC_Human1.60241951
26FUS_26573619_Chip-Seq_HEK293_Human1.56751928
27* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56189941
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.55966210
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54342080
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53894905
31* EWS_26573619_Chip-Seq_HEK293_Human1.53589745
32AR_21909140_ChIP-Seq_LNCAP_Human1.51988480
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51448948
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50389352
35PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48981730
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47635365
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.41519584
38BRD4_25478319_ChIP-Seq_HGPS_Human1.38582352
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34736151
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34455466
41FOXA2_19822575_ChIP-Seq_HepG2_Human1.32646803
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32156159
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32040634
44ISL1_27105846_Chip-Seq_CPCs_Mouse1.31848382
45GBX2_23144817_ChIP-Seq_PC3_Human1.27481974
46SOX9_26525672_Chip-Seq_HEART_Mouse1.27331105
47* STAT3_23295773_ChIP-Seq_U87_Human1.26139953
48CHD1_26751641_Chip-Seq_LNCaP_Human1.25865778
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25154970
50* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23919686
51WT1_19549856_ChIP-ChIP_CCG9911_Human1.19245426
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.18263531
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17512885
54* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16751701
55CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16678686
56CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16212750
57YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16068501
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15464927
59* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15387257
60* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14978083
61* TCF4_23295773_ChIP-Seq_U87_Human1.11113071
62* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10507170
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10431278
64TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08672684
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08547377
66TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07158256
67SMAD4_21799915_ChIP-Seq_A2780_Human1.06997948
68IGF1R_20145208_ChIP-Seq_DFB_Human1.04262961
69TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04135261
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03258269
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02508932
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01615548
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01152874
74SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99584519
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99568207
76WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99415590
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99188692
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.98931961
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98835999
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98835999
81EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98649567
82TAF15_26573619_Chip-Seq_HEK293_Human0.98300974
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97991425
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97521837
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97521837
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.96613321
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96078487
88STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95521857
89GF1B_26923725_Chip-Seq_HPCs_Mouse0.95016504
90CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94977122
91RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94146975
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93673153
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93069202
94* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92927813
95ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92638950
96FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92273957
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91445128
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89820606
99SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89764545
100* TCF7_22412390_ChIP-Seq_EML_Mouse0.89329713
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.88564434
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88517210
103AHR_22903824_ChIP-Seq_MCF-7_Human0.87710859
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87710142
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87573812
106RXR_22108803_ChIP-Seq_LS180_Human0.87495844
107MYC_22102868_ChIP-Seq_BL_Human0.86194632
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86182011
109RARB_27405468_Chip-Seq_BRAIN_Mouse0.85831419
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85566917
111FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83326338
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83084800
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82844255
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.82809027
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82659389
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82478656
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82326401
118AR_19668381_ChIP-Seq_PC3_Human0.82048112
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80692196
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.80392218
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80366104
122NOTCH1_21737748_ChIP-Seq_TLL_Human0.79842497
123NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.79702023
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.79563757
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.78460420
126ARNT_22903824_ChIP-Seq_MCF-7_Human0.77399264
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76601792
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76410768
129AR_21572438_ChIP-Seq_LNCaP_Human0.75769529
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.75684258
131P300_19829295_ChIP-Seq_ESCs_Human0.75174389
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74922714

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.09115341
2MP0008877_abnormal_DNA_methylation3.83772620
3MP0003787_abnormal_imprinting2.82790735
4MP0003121_genomic_imprinting2.74970502
5MP0008057_abnormal_DNA_replication2.53801585
6MP0003123_paternal_imprinting2.46208767
7MP0010234_abnormal_vibrissa_follicle2.43815595
8MP0010094_abnormal_chromosome_stability2.34264247
9MP0010352_gastrointestinal_tract_polyps2.33861056
10MP0005076_abnormal_cell_differentiation2.32902407
11MP0010307_abnormal_tumor_latency2.27990158
12MP0002877_abnormal_melanocyte_morpholog2.27827458
13MP0005409_darkened_coat_color2.26297841
14MP0003111_abnormal_nucleus_morphology2.14469646
15MP0003890_abnormal_embryonic-extraembry1.96758861
16MP0003077_abnormal_cell_cycle1.95316092
17MP0004808_abnormal_hematopoietic_stem1.79098553
18MP0002084_abnormal_developmental_patter1.64063932
19MP0002396_abnormal_hematopoietic_system1.63735387
20MP0003941_abnormal_skin_development1.60166153
21MP0001188_hyperpigmentation1.57337835
22MP0003705_abnormal_hypodermis_morpholog1.56194100
23MP0003937_abnormal_limbs/digits/tail_de1.54407168
24MP0005248_abnormal_Harderian_gland1.52678819
25MP0003122_maternal_imprinting1.52658244
26* MP0005380_embryogenesis_phenotype1.51170800
27* MP0001672_abnormal_embryogenesis/_devel1.51170800
28MP0004185_abnormal_adipocyte_glucose1.51144364
29MP0004197_abnormal_fetal_growth/weight/1.51012155
30MP0008007_abnormal_cellular_replicative1.50392535
31MP0005623_abnormal_meninges_morphology1.49021542
32* MP0003984_embryonic_growth_retardation1.46310866
33MP0005174_abnormal_tail_pigmentation1.45567248
34MP0003045_fibrosis1.45124045
35* MP0002088_abnormal_embryonic_growth/wei1.45059784
36MP0008058_abnormal_DNA_repair1.41725622
37MP0000350_abnormal_cell_proliferation1.41541010
38MP0000733_abnormal_muscle_development1.39528367
39MP0003935_abnormal_craniofacial_develop1.38728901
40* MP0002086_abnormal_extraembryonic_tissu1.38264081
41MP0001730_embryonic_growth_arrest1.35612176
42MP0009278_abnormal_bone_marrow1.35197440
43MP0009703_decreased_birth_body1.34965390
44* MP0002085_abnormal_embryonic_tissue1.31476872
45MP0002166_altered_tumor_susceptibility1.31428820
46MP0000432_abnormal_head_morphology1.31194113
47MP0010368_abnormal_lymphatic_system1.30835054
48MP0000566_synostosis1.30701578
49MP0000428_abnormal_craniofacial_morphol1.29248625
50MP0005367_renal/urinary_system_phenotyp1.28745688
51MP0000516_abnormal_urinary_system1.28745688
52MP0003693_abnormal_embryo_hatching1.27515441
53MP0004264_abnormal_extraembryonic_tissu1.27342423
54MP0003385_abnormal_body_wall1.26310183
55MP0000778_abnormal_nervous_system1.26154117
56MP0009697_abnormal_copulation1.23561873
57MP0000383_abnormal_hair_follicle1.19542668
58MP0003567_abnormal_fetal_cardiomyocyte1.18076536
59MP0001697_abnormal_embryo_size1.17713763
60MP0000534_abnormal_ureter_morphology1.16835294
61MP0003755_abnormal_palate_morphology1.15290775
62* MP0002925_abnormal_cardiovascular_devel1.13139450
63MP0002938_white_spotting1.12728124
64MP0003868_abnormal_feces_composition1.11356796
65MP0003091_abnormal_cell_migration1.11057715
66MP0002177_abnormal_outer_ear1.10576593
67MP0005187_abnormal_penis_morphology1.10369562
68MP0000537_abnormal_urethra_morphology1.08558347
69MP0001299_abnormal_eye_distance/1.08001930
70MP0010678_abnormal_skin_adnexa1.04832698
71MP0002210_abnormal_sex_determination1.03317338
72MP0009780_abnormal_chondrocyte_physiolo1.03247286
73MP0004957_abnormal_blastocyst_morpholog1.02356310
74MP0001293_anophthalmia1.02252059
75MP0003566_abnormal_cell_adhesion1.02084961
76MP0004084_abnormal_cardiac_muscle1.01593792
77MP0008932_abnormal_embryonic_tissue1.01334455
78MP0005275_abnormal_skin_tensile1.01118622
79MP0001545_abnormal_hematopoietic_system1.00701223
80MP0005397_hematopoietic_system_phenotyp1.00701223
81MP0004272_abnormal_basement_membrane1.00536953
82MP0002092_abnormal_eye_morphology0.99168018
83MP0009053_abnormal_anal_canal0.97770154
84MP0000015_abnormal_ear_pigmentation0.97506179
85* MP0001915_intracranial_hemorrhage0.96241508
86MP0003942_abnormal_urinary_system0.96148119
87MP0003315_abnormal_perineum_morphology0.95850282
88MP0000427_abnormal_hair_cycle0.95073046
89MP0002095_abnormal_skin_pigmentation0.94869580
90MP0002009_preneoplasia0.93771910
91MP0002116_abnormal_craniofacial_bone0.93044795
92MP0003115_abnormal_respiratory_system0.92517872
93MP0004145_abnormal_muscle_electrophysio0.91892226
94MP0004270_analgesia0.91170638
95MP0001348_abnormal_lacrimal_gland0.91052942
96MP0003943_abnormal_hepatobiliary_system0.89491219
97MP0008438_abnormal_cutaneous_collagen0.89304842
98MP0009672_abnormal_birth_weight0.89221015
99MP0001346_abnormal_lacrimal_gland0.88409855
100MP0003300_gastrointestinal_ulcer0.87993423
101MP0000377_abnormal_hair_follicle0.87295006
102MP0000762_abnormal_tongue_morphology0.86978666
103MP0002081_perinatal_lethality0.86759501
104MP0002108_abnormal_muscle_morphology0.86691977
105MP0008961_abnormal_basal_metabolism0.86202259
106MP0002796_impaired_skin_barrier0.85003278
107* MP0002080_prenatal_lethality0.82705897
108MP0002109_abnormal_limb_morphology0.82317526
109MP0002114_abnormal_axial_skeleton0.81750974
110MP0009250_abnormal_appendicular_skeleto0.81589071
111* MP0000266_abnormal_heart_morphology0.80937529
112MP0002006_tumorigenesis0.80348436
113MP0006138_congestive_heart_failure0.80044849
114* MP0003861_abnormal_nervous_system0.79909648
115MP0002233_abnormal_nose_morphology0.79893312
116MP0004036_abnormal_muscle_relaxation0.79648973
117MP0001145_abnormal_male_reproductive0.79507218
118MP0000653_abnormal_sex_gland0.79453368
119MP0002697_abnormal_eye_size0.78419541
120MP0004233_abnormal_muscle_weight0.78239663
121MP0005666_abnormal_adipose_tissue0.77712986
122MP0001879_abnormal_lymphatic_vessel0.76975735
123MP0001119_abnormal_female_reproductive0.76261896
124* MP0010630_abnormal_cardiac_muscle0.75665073
125MP0005621_abnormal_cell_physiology0.75163706
126MP0001286_abnormal_eye_development0.74123528
127MP0008995_early_reproductive_senescence0.73214081
128MP0000631_abnormal_neuroendocrine_gland0.73020074
129MP0004134_abnormal_chest_morphology0.72909601
130MP0002168_other_aberrant_phenotype0.72905726
131MP0002075_abnormal_coat/hair_pigmentati0.71669032
132MP0000579_abnormal_nail_morphology0.71468784
133MP0005503_abnormal_tendon_morphology0.71457872

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.22182349
2Volvulus (HP:0002580)3.65586486
3Chromsome breakage (HP:0040012)3.34832575
4Papillary thyroid carcinoma (HP:0002895)3.31891981
5Abnormality of the nasal septum (HP:0000419)3.20725456
6Short 4th metacarpal (HP:0010044)3.13169843
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.13169843
8Long eyelashes (HP:0000527)3.07104584
9Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98383041
10Ectopic kidney (HP:0000086)2.87966150
11Narrow palate (HP:0000189)2.74107722
12Abnormality of the labia minora (HP:0012880)2.61196733
13Acute myeloid leukemia (HP:0004808)2.59721927
14Macroorchidism (HP:0000053)2.59324966
15Dysmetric saccades (HP:0000641)2.57960289
16Lip pit (HP:0100267)2.45056990
17Urethral obstruction (HP:0000796)2.39386564
18Vertebral arch anomaly (HP:0008438)2.37369440
19Neoplasm of the adrenal cortex (HP:0100641)2.33643897
20Hepatoblastoma (HP:0002884)2.29615942
21Trigonocephaly (HP:0000243)2.28630052
22Cutaneous melanoma (HP:0012056)2.25208185
23Facial hemangioma (HP:0000329)2.21423294
24Broad thumb (HP:0011304)2.19588155
25Shallow orbits (HP:0000586)2.18835261
26Midline defect of the nose (HP:0004122)2.17195550
27Overgrowth (HP:0001548)2.16870280
28Abnormality of chromosome stability (HP:0003220)2.15493108
29Deep philtrum (HP:0002002)2.14749640
30Truncal obesity (HP:0001956)2.14668706
31Spinal cord lesions (HP:0100561)2.12968242
32Syringomyelia (HP:0003396)2.12968242
33Overlapping toe (HP:0001845)2.11424637
34Abnormality of the 4th metacarpal (HP:0010012)2.10345195
35Prominent nose (HP:0000448)2.10251091
36Supernumerary ribs (HP:0005815)2.09768223
37Neoplasm of the oral cavity (HP:0100649)2.08661139
38Advanced eruption of teeth (HP:0006288)2.08165909
39Medulloblastoma (HP:0002885)2.06506255
40Abnormality of the parietal bone (HP:0002696)2.01071058
41Absent frontal sinuses (HP:0002688)1.99537441
42Anal stenosis (HP:0002025)1.98792265
43Insidious onset (HP:0003587)1.98722225
44Termporal pattern (HP:0011008)1.98722225
45Cubitus valgus (HP:0002967)1.98712085
46Glioma (HP:0009733)1.96684700
47Heterotopia (HP:0002282)1.95992645
48Distal lower limb amyotrophy (HP:0008944)1.95526866
49Low anterior hairline (HP:0000294)1.94366817
50Increased number of teeth (HP:0011069)1.93683502
51Thyroid carcinoma (HP:0002890)1.92968934
52Prostate neoplasm (HP:0100787)1.92773212
53Obsessive-compulsive behavior (HP:0000722)1.92758659
54Increased nuchal translucency (HP:0010880)1.91158659
55High anterior hairline (HP:0009890)1.90777453
56Hypoplasia of the maxilla (HP:0000327)1.90052807
57Abnormality of chromosome segregation (HP:0002916)1.89592813
58Asymmetry of the thorax (HP:0001555)1.89399186
59Hypoplastic labia majora (HP:0000059)1.88360719
60Genetic anticipation (HP:0003743)1.88342973
61Missing ribs (HP:0000921)1.88246980
62Deviation of the thumb (HP:0009603)1.87684183
63Abnormality of the distal phalanx of the thumb (HP:0009617)1.87246641
64Subacute progressive viral hepatitis (HP:0006572)1.86978076
65Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86886330
66Septate vagina (HP:0001153)1.86037639
67Hypoplastic ischia (HP:0003175)1.85667732
68Short chin (HP:0000331)1.85356843
69Abnormal hair whorl (HP:0010721)1.84763997
70Skull defect (HP:0001362)1.83021460
71Abnormality of the columella (HP:0009929)1.82806026
72Supernumerary bones of the axial skeleton (HP:0009144)1.81197020
73Lower limb amyotrophy (HP:0007210)1.80268308
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.79513217
75Thick eyebrow (HP:0000574)1.79350974
76Abnormality of the astrocytes (HP:0100707)1.78375406
77Astrocytoma (HP:0009592)1.78375406
78Broad face (HP:0000283)1.77931681
79Cystic hygroma (HP:0000476)1.77758703
80Transitional cell carcinoma of the bladder (HP:0006740)1.77727558
81Broad phalanges of the hand (HP:0009768)1.77361280
82Sparse lateral eyebrow (HP:0005338)1.76965903
83Proximal placement of thumb (HP:0009623)1.76524771
84Abnormality of the incisor (HP:0000676)1.76434096
85Acute lymphatic leukemia (HP:0006721)1.75069699
86Abnormality of the phalanges of the hallux (HP:0010057)1.75062873
87Abnormality of the epiphyses of the hand (HP:0005924)1.73419973
8811 pairs of ribs (HP:0000878)1.73233901
89Sandal gap (HP:0001852)1.72560931
90Abnormality of incisor morphology (HP:0011063)1.72484133
91Laryngomalacia (HP:0001601)1.72091534
92Curly hair (HP:0002212)1.71742403
93Abnormality of the labia majora (HP:0012881)1.71558768
94Ankyloglossia (HP:0010296)1.70421220
95Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.70255465
96Uterine leiomyosarcoma (HP:0002891)1.70141060
97Leiomyosarcoma (HP:0100243)1.70141060
98Abnormality of the carotid arteries (HP:0005344)1.69805444
99Flat acetabular roof (HP:0003180)1.69156298
100Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.68042956
101Broad finger (HP:0001500)1.67936818
102Depressed nasal tip (HP:0000437)1.66454117
103Bladder carcinoma (HP:0002862)1.66258182
104Bladder neoplasm (HP:0009725)1.66258182
105Smooth philtrum (HP:0000319)1.65873562
106Hypopigmentation of the fundus (HP:0007894)1.65606770
107Deep palmar crease (HP:0006191)1.64636119
108Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63949120
109Renovascular hypertension (HP:0100817)1.63737211
110Dental malocclusion (HP:0000689)1.63266671
111Dislocated radial head (HP:0003083)1.62884918
112Malignant gastrointestinal tract tumors (HP:0006749)1.62879900
113Gastrointestinal carcinoma (HP:0002672)1.62879900
114Open mouth (HP:0000194)1.61259188
115Aqueductal stenosis (HP:0002410)1.61204531
116Meckel diverticulum (HP:0002245)1.60794191
117Aplasia/Hypoplasia of the uvula (HP:0010293)1.60598376
118Hypospadias (HP:0000047)1.59771822
119Broad phalanx (HP:0006009)1.59712539
120Drooling (HP:0002307)1.59664616
121Hyperacusis (HP:0010780)1.58852885
122Cutis marmorata (HP:0000965)1.58575542
123Shawl scrotum (HP:0000049)1.57889773
124Obstructive sleep apnea (HP:0002870)1.56677935
125Persistence of primary teeth (HP:0006335)1.56544034
126Relative macrocephaly (HP:0004482)1.56504637
127Cortical dysplasia (HP:0002539)1.56060787
128Microglossia (HP:0000171)1.55992680
129Capillary hemangiomas (HP:0005306)1.55751854
130Exostoses (HP:0100777)1.55596047
131Mitral valve prolapse (HP:0001634)1.55485129
132Broad palm (HP:0001169)1.54202061
133Abnormal number of incisors (HP:0011064)1.54121180
134Abnormality of the ischium (HP:0003174)1.53211065
135Bifid scrotum (HP:0000048)1.52221080
136Decreased lacrimation (HP:0000633)1.51406540
137Broad long bones (HP:0005622)1.50566214
138Abnormality of the radial head (HP:0003995)1.50416399
139Right ventricular cardiomyopathy (HP:0011663)1.50250594
140Limited elbow extension (HP:0001377)1.50144053
141Tracheomalacia (HP:0002779)1.49823540
142Tapered finger (HP:0001182)1.49191695
143Neonatal hypoglycemia (HP:0001998)1.48842811
144Abnormality of the ileum (HP:0001549)1.47867388
145Oligodontia (HP:0000677)1.47284119
146Synophrys (HP:0000664)1.45748476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.96692767
2LATS13.89485356
3CDC73.55035291
4BRD43.09562921
5STK32.52756680
6CAMK1D2.32209933
7ICK2.26150434
8CAMK1G2.08555715
9CDK92.02362631
10MKNK21.91563787
11NUAK11.91335870
12ZAK1.85030047
13LATS21.76020791
14PLK41.69782027
15TTK1.68469298
16DMPK1.65035599
17MKNK11.51230815
18ATR1.45878627
19MELK1.42742268
20SGK21.34122849
21ATM1.32913490
22FRK1.32852707
23SGK31.31211200
24* MTOR1.29487225
25EIF2AK31.26036819
26WNK11.25053389
27CHEK11.24183211
28FGFR31.23896003
29MET1.22781175
30ALK1.22726760
31TNIK1.21859002
32NEK91.21407797
33STK38L1.20534975
34RIPK11.15761088
35MARK11.14804066
36STK41.13666442
37CDK61.12584586
38STK241.12394503
39AKT31.11369912
40TRIB31.10564005
41CHEK21.08471999
42PLK31.07592088
43EIF2AK11.06549482
44SRPK11.04909552
45NLK1.00981613
46MAP3K21.00525592
47FGFR41.00001447
48MARK20.99608694
49STK390.99427517
50NEK20.98845463
51PDGFRB0.97871966
52WNK40.97610147
53MAP3K60.97455904
54ACVR1B0.97385232
55CDK40.97076776
56PLK20.94643828
57CHUK0.93928261
58CASK0.89471917
59MAP3K90.88309943
60TRPM70.86096451
61KSR20.85964276
62MAP3K40.85053920
63PNCK0.83765138
64* CDK20.83261406
65CSNK1A1L0.83032758
66CDK70.79430942
67RAF10.79395915
68PLK10.78956842
69FGFR20.78749702
70BCR0.77976996
71JAK30.77756847
72TYRO30.77258563
73SGK10.77023676
74KSR10.75999523
75NTRK10.75654282
76MAPK140.75303454
77CDK10.74009366
78SCYL20.73815039
79CDC42BPA0.73659444
80PDGFRA0.72394105
81MST1R0.72034153
82FGFR10.71949354
83PKN20.71893587
84YES10.69767747
85MAPK100.67399498
86MATK0.66254402
87SMG10.66220197
88EPHA20.65665101
89CSNK1E0.64988673
90AURKB0.64322990
91CSNK1D0.64304793
92GSK3B0.63333035
93PRKDC0.61901552
94EPHA30.61671382
95MAP3K50.61349052
96TAOK10.61214385
97TAF10.60998586
98CDK80.59213497
99RET0.57259151
100TAOK30.57078890
101AKT10.56231026
102NEK60.55954521
103MAPK10.55877386
104ERBB30.55426279
105TSSK60.55185272
106PRKAA10.55097528
107FER0.54773269
108STK100.53172267
109CAMK40.50726255
110PAK20.49272827
111TTN0.49036856
112MAP3K130.48519851
113CDK30.48139063
114MAPK80.46481734
115SIK10.45526814
116SGK2230.45271423
117SGK4940.45271423
118MAP3K100.45106793
119PIK3CA0.45103680
120PTK60.44536098
121RPS6KB10.44233432
122CSNK1G10.43502470
123RPS6KA30.42882332
124BRSK20.42216116
125NTRK20.41890908
126RPS6KB20.40834868
127JAK10.40541512
128STK380.39376730
129MARK30.38713048
130PAK30.38507107
131EIF2AK20.37858621
132EEF2K0.36815063
133NTRK30.36103110
134MAP3K140.33700239
135PRKAA20.33644008
136PTK20.32536743

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041101.97865032
2MicroRNAs in cancer_Homo sapiens_hsa052061.74963133
3Fatty acid biosynthesis_Homo sapiens_hsa000611.74819125
4Fanconi anemia pathway_Homo sapiens_hsa034601.73647202
5Lysine degradation_Homo sapiens_hsa003101.66872316
6Adherens junction_Homo sapiens_hsa045201.65859290
7mRNA surveillance pathway_Homo sapiens_hsa030151.60333691
8Dorso-ventral axis formation_Homo sapiens_hsa043201.59893257
9TGF-beta signaling pathway_Homo sapiens_hsa043501.39535135
10Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39386195
11Prostate cancer_Homo sapiens_hsa052151.37702859
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.37681945
13Endometrial cancer_Homo sapiens_hsa052131.37352753
14Small cell lung cancer_Homo sapiens_hsa052221.36415663
15RNA transport_Homo sapiens_hsa030131.36337896
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35666644
17Non-homologous end-joining_Homo sapiens_hsa034501.35625627
18Chronic myeloid leukemia_Homo sapiens_hsa052201.33449176
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29905883
20Basal transcription factors_Homo sapiens_hsa030221.29520586
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28990012
22Transcriptional misregulation in cancer_Homo sapiens_hsa052021.24723260
23Homologous recombination_Homo sapiens_hsa034401.24151593
24Pancreatic cancer_Homo sapiens_hsa052121.20849032
25Thyroid cancer_Homo sapiens_hsa052161.19169259
26Colorectal cancer_Homo sapiens_hsa052101.18517493
27mTOR signaling pathway_Homo sapiens_hsa041501.17241384
28Basal cell carcinoma_Homo sapiens_hsa052171.16166291
29FoxO signaling pathway_Homo sapiens_hsa040681.14034820
30Hippo signaling pathway_Homo sapiens_hsa043901.13198851
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11132415
32p53 signaling pathway_Homo sapiens_hsa041151.10596516
33Proteoglycans in cancer_Homo sapiens_hsa052051.10148096
34RNA degradation_Homo sapiens_hsa030181.08706657
35Notch signaling pathway_Homo sapiens_hsa043301.06698832
36Herpes simplex infection_Homo sapiens_hsa051681.05286451
37Mismatch repair_Homo sapiens_hsa034301.05167755
38Wnt signaling pathway_Homo sapiens_hsa043101.04997308
39Viral myocarditis_Homo sapiens_hsa054161.04718789
40HTLV-I infection_Homo sapiens_hsa051661.04476276
41Non-small cell lung cancer_Homo sapiens_hsa052231.04398900
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.03880852
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03752442
44Insulin signaling pathway_Homo sapiens_hsa049101.02631642
45Glioma_Homo sapiens_hsa052141.02430987
46Type II diabetes mellitus_Homo sapiens_hsa049301.00872639
47Oocyte meiosis_Homo sapiens_hsa041141.00738167
48Focal adhesion_Homo sapiens_hsa045101.00410150
49AMPK signaling pathway_Homo sapiens_hsa041520.99288333
50Viral carcinogenesis_Homo sapiens_hsa052030.98306114
51Thyroid hormone synthesis_Homo sapiens_hsa049180.97602625
52ErbB signaling pathway_Homo sapiens_hsa040120.97405846
53ECM-receptor interaction_Homo sapiens_hsa045120.97200505
54Prolactin signaling pathway_Homo sapiens_hsa049170.94306221
55Hepatitis B_Homo sapiens_hsa051610.94154135
56Acute myeloid leukemia_Homo sapiens_hsa052210.94102885
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93509870
58Pathways in cancer_Homo sapiens_hsa052000.91569156
59Glucagon signaling pathway_Homo sapiens_hsa049220.90617662
60Toxoplasmosis_Homo sapiens_hsa051450.90150605
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.89674513
62TNF signaling pathway_Homo sapiens_hsa046680.89555901
63Long-term depression_Homo sapiens_hsa047300.88897296
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88597596
65Renal cell carcinoma_Homo sapiens_hsa052110.88046677
66Hedgehog signaling pathway_Homo sapiens_hsa043400.85898351
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84979802
68Melanoma_Homo sapiens_hsa052180.83873556
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83852680
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83703106
71Influenza A_Homo sapiens_hsa051640.82883759
72Gap junction_Homo sapiens_hsa045400.82196545
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81502959
74Choline metabolism in cancer_Homo sapiens_hsa052310.81305760
75MAPK signaling pathway_Homo sapiens_hsa040100.80738511
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80346813
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80107528
78Dilated cardiomyopathy_Homo sapiens_hsa054140.80009458
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78644313
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78461699
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78380887
82Circadian rhythm_Homo sapiens_hsa047100.77742544
83One carbon pool by folate_Homo sapiens_hsa006700.77019450
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76498864
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76179289
86Measles_Homo sapiens_hsa051620.75069525
87VEGF signaling pathway_Homo sapiens_hsa043700.74178452
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74107312
89Long-term potentiation_Homo sapiens_hsa047200.72149764
90Melanogenesis_Homo sapiens_hsa049160.72086363
91Osteoclast differentiation_Homo sapiens_hsa043800.71588545
92Estrogen signaling pathway_Homo sapiens_hsa049150.70265156
93Epstein-Barr virus infection_Homo sapiens_hsa051690.69365804
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69276363
95Tight junction_Homo sapiens_hsa045300.68723398
96DNA replication_Homo sapiens_hsa030300.68641900
97Platelet activation_Homo sapiens_hsa046110.67680391
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67485360
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66947604
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.66889711
101Spliceosome_Homo sapiens_hsa030400.66886073
102B cell receptor signaling pathway_Homo sapiens_hsa046620.65974259
103T cell receptor signaling pathway_Homo sapiens_hsa046600.65494819
104Axon guidance_Homo sapiens_hsa043600.64528305
105HIF-1 signaling pathway_Homo sapiens_hsa040660.62793194
106Rap1 signaling pathway_Homo sapiens_hsa040150.62563694
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62161206
108GnRH signaling pathway_Homo sapiens_hsa049120.61996603
109Bladder cancer_Homo sapiens_hsa052190.61988218
110Steroid biosynthesis_Homo sapiens_hsa001000.60031626
111Cholinergic synapse_Homo sapiens_hsa047250.59897041
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.59709559
113Dopaminergic synapse_Homo sapiens_hsa047280.59346380
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58948687
115Insulin resistance_Homo sapiens_hsa049310.58555717
116Base excision repair_Homo sapiens_hsa034100.58197683
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.57978084
118Inositol phosphate metabolism_Homo sapiens_hsa005620.57970022
119Glutamatergic synapse_Homo sapiens_hsa047240.57761744
120Ovarian steroidogenesis_Homo sapiens_hsa049130.57602105
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57284984
122cAMP signaling pathway_Homo sapiens_hsa040240.55128483
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54055605
124Insulin secretion_Homo sapiens_hsa049110.53548668
125Vitamin B6 metabolism_Homo sapiens_hsa007500.52837302
126Ras signaling pathway_Homo sapiens_hsa040140.51130732

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