ANKRD16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.23464138
2regulation of gamma-delta T cell differentiation (GO:0045586)5.11282182
3behavioral response to nicotine (GO:0035095)4.78570810
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67245145
5regulation of gamma-delta T cell activation (GO:0046643)4.59257064
6histone H3-K4 trimethylation (GO:0080182)4.53483315
7response to interleukin-15 (GO:0070672)4.44502621
8protein complex biogenesis (GO:0070271)4.29762204
9cellular response to interleukin-15 (GO:0071350)4.27466898
10peptidyl-histidine modification (GO:0018202)4.11934936
11response to pheromone (GO:0019236)4.02749857
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99800464
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99800464
14ubiquinone biosynthetic process (GO:0006744)3.99407408
15mitochondrial respiratory chain complex assembly (GO:0033108)3.98770257
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.97886030
17NADH dehydrogenase complex assembly (GO:0010257)3.97886030
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.97886030
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.96911207
20negative regulation of cell killing (GO:0031342)3.96911207
21pseudouridine synthesis (GO:0001522)3.93987242
22antigen processing and presentation of endogenous antigen (GO:0019883)3.89362205
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.82182058
24respiratory chain complex IV assembly (GO:0008535)3.79178093
25cytochrome complex assembly (GO:0017004)3.75007537
26histone H3-K4 methylation (GO:0051568)3.74628676
27GTP biosynthetic process (GO:0006183)3.67369547
28peptidyl-lysine trimethylation (GO:0018023)3.62764478
29replication fork processing (GO:0031297)3.57461717
30ubiquinone metabolic process (GO:0006743)3.56840958
31negative regulation of erythrocyte differentiation (GO:0045647)3.55298753
32positive regulation of histone deacetylation (GO:0031065)3.50668397
33detection of light stimulus involved in visual perception (GO:0050908)3.49619059
34detection of light stimulus involved in sensory perception (GO:0050962)3.49619059
35mannosylation (GO:0097502)3.48976074
36negative regulation of telomere maintenance (GO:0032205)3.48385088
37positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.47053764
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.43302132
39ATP synthesis coupled proton transport (GO:0015986)3.43302132
40DNA deamination (GO:0045006)3.41941646
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.36441468
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.36441468
43negative thymic T cell selection (GO:0045060)3.34509534
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29193473
45growth hormone receptor signaling pathway (GO:0060396)3.28859023
46positive regulation of prostaglandin secretion (GO:0032308)3.28423891
47tRNA modification (GO:0006400)3.28412859
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.26841574
49negative T cell selection (GO:0043383)3.26440261
50opioid receptor signaling pathway (GO:0038003)3.26421880
51antigen processing and presentation via MHC class Ib (GO:0002475)3.25685708
52DNA methylation involved in gamete generation (GO:0043046)3.24544063
53peptidyl-lysine methylation (GO:0018022)3.23775502
54maturation of 5.8S rRNA (GO:0000460)3.20041143
55regulation of B cell receptor signaling pathway (GO:0050855)3.19334883
56UTP biosynthetic process (GO:0006228)3.19253913
57quinone biosynthetic process (GO:1901663)3.17524696
58negative regulation of granulocyte differentiation (GO:0030853)3.14365567
59peptidyl-lysine dimethylation (GO:0018027)3.13368963
60tRNA processing (GO:0008033)3.12510930
61stress granule assembly (GO:0034063)3.11706595
62UTP metabolic process (GO:0046051)3.10674752
63positive thymic T cell selection (GO:0045059)3.09150553
64L-fucose catabolic process (GO:0042355)3.07820668
65fucose catabolic process (GO:0019317)3.07820668
66L-fucose metabolic process (GO:0042354)3.07820668
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.07082255
68positive regulation of B cell differentiation (GO:0045579)3.06830666
69maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01652789
70B cell receptor signaling pathway (GO:0050853)2.98983235
71indole-containing compound catabolic process (GO:0042436)2.98912619
72indolalkylamine catabolic process (GO:0046218)2.98912619
73tryptophan catabolic process (GO:0006569)2.98912619
74protein-cofactor linkage (GO:0018065)2.97995494
75cellular ketone body metabolic process (GO:0046950)2.96125967
76mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95833333
77preassembly of GPI anchor in ER membrane (GO:0016254)2.94091415
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91716507
79piRNA metabolic process (GO:0034587)2.90345010
80positive regulation of fatty acid transport (GO:2000193)2.90266089
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90234467
82valine metabolic process (GO:0006573)2.89950864
83water-soluble vitamin biosynthetic process (GO:0042364)2.87475082
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85894810
85thymic T cell selection (GO:0045061)2.85857335
86oxidative phosphorylation (GO:0006119)2.83692098
87purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82379367
88regulation of regulatory T cell differentiation (GO:0045589)2.81602247
89kynurenine metabolic process (GO:0070189)2.79977805
90T cell selection (GO:0045058)2.76936567
91alpha-linolenic acid metabolic process (GO:0036109)2.76811122
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76792746
93dicarboxylic acid biosynthetic process (GO:0043650)2.76709493
94histone lysine methylation (GO:0034968)2.75456799
95regulation of mitochondrial translation (GO:0070129)2.74945956
96cellular response to growth hormone stimulus (GO:0071378)2.74866143
97regulation of B cell differentiation (GO:0045577)2.72651317
98nucleoside diphosphate phosphorylation (GO:0006165)2.71679552
99positive T cell selection (GO:0043368)2.71486592
100pre-miRNA processing (GO:0031054)2.70858737
101termination of RNA polymerase III transcription (GO:0006386)2.70549993
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.70549993
103kidney morphogenesis (GO:0060993)2.69022113
104resolution of meiotic recombination intermediates (GO:0000712)2.68636070
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.68228044
106regulation of translation, ncRNA-mediated (GO:0045974)2.68228044
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68228044
108indolalkylamine metabolic process (GO:0006586)2.68062286
109glycerophospholipid catabolic process (GO:0046475)2.67748605
110histone H4-K16 acetylation (GO:0043984)2.66091620
111I-kappaB phosphorylation (GO:0007252)2.65798502
112JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.64471123
113regulation of granulocyte differentiation (GO:0030852)2.63139382
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62468120
115branched-chain amino acid catabolic process (GO:0009083)2.61828375
116positive regulation of icosanoid secretion (GO:0032305)2.60802899
117electron transport chain (GO:0022900)2.60691158
118ATP biosynthetic process (GO:0006754)2.60165946
119epithelial cilium movement (GO:0003351)2.60017955
120metallo-sulfur cluster assembly (GO:0031163)2.58632668
121iron-sulfur cluster assembly (GO:0016226)2.58632668
122primary amino compound metabolic process (GO:1901160)2.57306889
123gamma-aminobutyric acid transport (GO:0015812)2.57148159
124insulin-like growth factor receptor signaling pathway (GO:0048009)2.56962430
125ketone body metabolic process (GO:1902224)2.55509121
126adaptation of signaling pathway (GO:0023058)2.54762664
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.54600934
128CTP biosynthetic process (GO:0006241)2.54364574
129CTP metabolic process (GO:0046036)2.54364574
130respiratory electron transport chain (GO:0022904)2.53671503
131tricarboxylic acid metabolic process (GO:0072350)2.53630208
132mitochondrial RNA metabolic process (GO:0000959)2.53543008
133positive regulation of protein deacetylation (GO:0090312)2.53328715
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53247389
135coronary vasculature morphogenesis (GO:0060977)2.53239939
136DNA double-strand break processing (GO:0000729)2.53093812
137translesion synthesis (GO:0019985)2.52983901
138exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51047960
139phospholipid homeostasis (GO:0055091)2.50879575
140tryptophan metabolic process (GO:0006568)2.50630428
141guanosine-containing compound biosynthetic process (GO:1901070)2.50562224
142alanine transport (GO:0032328)2.49843540
143somite rostral/caudal axis specification (GO:0032525)2.49535412
144ribonucleoside triphosphate biosynthetic process (GO:0009201)2.49149465
145negative regulation of RNA splicing (GO:0033119)2.48325317
146regulation of histone H3-K27 methylation (GO:0061085)2.47879121
147dendritic cell chemotaxis (GO:0002407)2.46989087
148nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46252786
149embryonic viscerocranium morphogenesis (GO:0048703)2.46192824
150regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45717522
151regulation of mitotic spindle checkpoint (GO:1903504)2.45717522
152amine catabolic process (GO:0009310)2.45186352
153cellular biogenic amine catabolic process (GO:0042402)2.45186352
154somite development (GO:0061053)2.43895119
155NAD biosynthetic process (GO:0009435)2.43780403
156positive regulation of Rap GTPase activity (GO:0032854)2.43773399
157platelet dense granule organization (GO:0060155)2.43460526
158protein K6-linked ubiquitination (GO:0085020)2.43287975
159regulation of T cell tolerance induction (GO:0002664)2.43077130
160regulation of fatty acid beta-oxidation (GO:0031998)2.42239922
161regulation of telomere maintenance (GO:0032204)2.42177130
162indole-containing compound metabolic process (GO:0042430)2.42099006
163triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.41655699
164embryonic hemopoiesis (GO:0035162)2.40195049
165response to type I interferon (GO:0034340)2.39970633
166negative regulation of histone methylation (GO:0031061)2.39874378
167mucosal-associated lymphoid tissue development (GO:0048537)2.38133737
168Peyers patch development (GO:0048541)2.38133737
169negative regulation of cell size (GO:0045792)2.37298592
170regulation of glycolytic process (GO:0006110)2.36676135
171regulation of erythrocyte differentiation (GO:0045646)2.36031538
172negative regulation of cholesterol transport (GO:0032375)2.34071590
173negative regulation of sterol transport (GO:0032372)2.34071590
174snRNA transcription (GO:0009301)2.33753854
175natural killer cell differentiation (GO:0001779)2.33305668
176positive regulation of cholesterol efflux (GO:0010875)2.32680090
177cellular response to prostaglandin stimulus (GO:0071379)2.30992276
178positive regulation of granulocyte differentiation (GO:0030854)2.29252633
179cellular response to type I interferon (GO:0071357)2.28960146
180type I interferon signaling pathway (GO:0060337)2.28960146
181regulation of ARF GTPase activity (GO:0032312)2.28847011
182mRNA splice site selection (GO:0006376)2.27224436
183T cell migration (GO:0072678)2.24014431
184histone H4-K8 acetylation (GO:0043982)2.23854474
185histone H4-K5 acetylation (GO:0043981)2.23854474
186phospholipid efflux (GO:0033700)2.22221141
187JAK-STAT cascade (GO:0007259)2.21652727
188negative regulation of sodium ion transport (GO:0010766)2.20601108
189COPI coating of Golgi vesicle (GO:0048205)2.20230013
190Golgi transport vesicle coating (GO:0048200)2.20230013
191positive regulation of cholesterol transport (GO:0032376)2.19606824
192positive regulation of sterol transport (GO:0032373)2.19606824
193response to growth hormone (GO:0060416)2.19278703
194dendritic cell migration (GO:0036336)2.18780416
195thrombin receptor signaling pathway (GO:0070493)2.18739775
196heparin metabolic process (GO:0030202)2.18582759
197heparin biosynthetic process (GO:0030210)2.18582759
198T cell homeostasis (GO:0043029)2.18567599

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.92175514
2MYC_22102868_ChIP-Seq_BL_Human3.78556941
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72926384
4ZNF274_21170338_ChIP-Seq_K562_Hela3.72440980
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42389160
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21851905
7EZH2_22144423_ChIP-Seq_EOC_Human2.93413773
8VDR_21846776_ChIP-Seq_THP-1_Human2.87135614
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.79788362
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79297936
11TCF7_22412390_ChIP-Seq_EML_Mouse2.77395101
12GATA1_22025678_ChIP-Seq_K562_Human2.76332529
13SCL_19346495_ChIP-Seq_HPC-7_Human2.72205873
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71876166
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.71209792
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.60788930
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58768952
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57318051
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55270823
20VDR_22108803_ChIP-Seq_LS180_Human2.54396291
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.49821535
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46305743
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.45669947
24KDM2B_26808549_Chip-Seq_DND41_Human2.36469764
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36384155
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35278817
27MYC_18940864_ChIP-ChIP_HL60_Human2.32897139
28RUNX_20019798_ChIP-Seq_JUKART_Human2.32596382
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.24706294
30NOTCH1_21737748_ChIP-Seq_TLL_Human2.24172308
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20116234
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19771569
33* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.19345310
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17010902
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16977335
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.16458752
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16059107
38CIITA_25753668_ChIP-Seq_RAJI_Human2.14604723
39MAF_26560356_Chip-Seq_TH1_Human2.11007511
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05425322
41IRF1_19129219_ChIP-ChIP_H3396_Human2.05151508
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99160376
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.94834457
44UTX_26944678_Chip-Seq_JUKART_Human1.93986219
45* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90074010
46VDR_24763502_ChIP-Seq_THP-1_Human1.89720463
47LXR_22292898_ChIP-Seq_THP-1_Human1.89319941
48SPI1_23127762_ChIP-Seq_K562_Human1.89314319
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.88751850
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87851624
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85496394
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.84995557
53* CBX2_27304074_Chip-Seq_ESCs_Mouse1.84992099
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84363424
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83736219
56VDR_23849224_ChIP-Seq_CD4+_Human1.83337503
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83116252
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81803918
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.80033645
60MYB_26560356_Chip-Seq_TH2_Human1.77108251
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73560950
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73393524
63MYB_26560356_Chip-Seq_TH1_Human1.72014160
64TP53_22573176_ChIP-Seq_HFKS_Human1.71963963
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71239779
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68363693
67EWS_26573619_Chip-Seq_HEK293_Human1.68314349
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65517611
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.65028049
70ERA_21632823_ChIP-Seq_H3396_Human1.62834475
71FOXM1_23109430_ChIP-Seq_U2OS_Human1.62001662
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60897329
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.59942517
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.56183371
75RNF2_27304074_Chip-Seq_NSC_Mouse1.55375872
76CLOCK_20551151_ChIP-Seq_293T_Human1.52326837
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50371043
78YY1_21170310_ChIP-Seq_MESCs_Mouse1.50212185
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50178675
80* GABP_19822575_ChIP-Seq_HepG2_Human1.49252122
81GBX2_23144817_ChIP-Seq_PC3_Human1.48138776
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47430679
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44579715
84REST_21632747_ChIP-Seq_MESCs_Mouse1.43460510
85KDM5A_27292631_Chip-Seq_BREAST_Human1.42280485
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.41500704
87LXR_22158963_ChIP-Seq_LIVER_Mouse1.41303179
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40048062
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.38685371
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38635398
91FOXP3_21729870_ChIP-Seq_TREG_Human1.37890649
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36253967
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36162510
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35597721
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35519811
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35325752
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34869120
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33307037
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32887947
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32561124
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31712438
102* KDM2B_26808549_Chip-Seq_K562_Human1.31325039
103DROSHA_22980978_ChIP-Seq_HELA_Human1.31243196
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29995029
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29891028
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29179777
107GATA1_19941826_ChIP-Seq_K562_Human1.28911929
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.28682303
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28682303
110ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28440877
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27017111
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.26443652
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26351476
114VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26274664
115GATA3_27048872_Chip-Seq_THYMUS_Human1.24780775
116TAF2_19829295_ChIP-Seq_ESCs_Human1.24731360
117TTF2_22483619_ChIP-Seq_HELA_Human1.23790497
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23400304
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22916537
120MAF_26560356_Chip-Seq_TH2_Human1.22258491
121EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22074436
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22001961
123* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21876379
124SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21639280
125SPI1_23547873_ChIP-Seq_NB4_Human1.20952165
126MYC_18555785_ChIP-Seq_MESCs_Mouse1.20496610
127ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20219770
128MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20163179
129IGF1R_20145208_ChIP-Seq_DFB_Human1.20101976
130ESR2_21235772_ChIP-Seq_MCF-7_Human1.18176156
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18065013
132JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18054974
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16805905
134CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16764265
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16371118
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16059469
137EZH2_27304074_Chip-Seq_ESCs_Mouse1.15812582
138ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15754302
139EZH2_27294783_Chip-Seq_ESCs_Mouse1.15333516
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13286975
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13234854
142CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12412171
143ER_23166858_ChIP-Seq_MCF-7_Human1.11487576
144YY1_22570637_ChIP-Seq_MALME-3M_Human1.11330969
145ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11175862
146E2F1_20622854_ChIP-Seq_HELA_Human1.10898131
147P53_21459846_ChIP-Seq_SAOS-2_Human1.10183576
148XRN2_22483619_ChIP-Seq_HELA_Human1.09815150
149IRF8_21731497_ChIP-ChIP_J774_Mouse1.09398316
150AR_20517297_ChIP-Seq_VCAP_Human1.08572224
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08519552
152HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08137709
153PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07430489
154FOXP1_21924763_ChIP-Seq_HESCs_Human1.06965998
155ESR1_21235772_ChIP-Seq_MCF-7_Human1.06196747
156FUS_26573619_Chip-Seq_HEK293_Human1.05553037
157NCOR_22424771_ChIP-Seq_293T_Human1.04779300
158SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04547410
159NCOR1_26117541_ChIP-Seq_K562_Human1.04156173
160TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03813171
161REST_18959480_ChIP-ChIP_MESCs_Mouse1.03230585
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02803748
163RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02553030
164* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01680456
165DCP1A_22483619_ChIP-Seq_HELA_Human1.01218209
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00600524
167MYC_19829295_ChIP-Seq_ESCs_Human1.00478036
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00244478
169GATA2_21666600_ChIP-Seq_HMVEC_Human0.99587297
170CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97758396
171SALL1_21062744_ChIP-ChIP_HESCs_Human0.97755408
172PHF8_20622854_ChIP-Seq_HELA_Human0.97749435
173P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97746129
174HOXB7_26014856_ChIP-Seq_BT474_Human0.97707289
175CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97648724
176EED_16625203_ChIP-ChIP_MESCs_Mouse0.97133584
177RAC3_21632823_ChIP-Seq_H3396_Human0.96423219
178LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96172609
179GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96060718
180CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95674965
181FOXA2_19822575_ChIP-Seq_HepG2_Human0.95668563
182RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94876658
183GATA2_19941826_ChIP-Seq_K562_Human0.94395929
184TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94076102
185PU_27001747_Chip-Seq_BMDM_Mouse0.94047860
186* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93080474
187SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93065899
188* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91889932
189NANOG_20526341_ChIP-Seq_ESCs_Human0.91523968
190* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91227853
191WDR5_24793694_ChIP-Seq_LNCAP_Human0.90701205
192EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90497427
193CREB1_26743006_Chip-Seq_LNCaP_Human0.90297495
194STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90242841
195JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89906439
196TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86854146
197FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.86805457
198BCL6_27268052_Chip-Seq_Bcells_Human0.86197082
199TBX20_22080862_ChIP-Seq_HEART_Mouse0.85097117
200TBX20_22328084_ChIP-Seq_HEART_Mouse0.85097117

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.48935449
2MP0003283_abnormal_digestive_organ3.37131575
3MP0001835_abnormal_antigen_presentation2.99888397
4MP0008877_abnormal_DNA_methylation2.99110262
5MP0003172_abnormal_lysosome_physiology2.95831198
6MP0003300_gastrointestinal_ulcer2.68244408
7MP0008961_abnormal_basal_metabolism2.54261739
8MP0003183_abnormal_peptide_metabolism2.53982111
9MP0002234_abnormal_pharynx_morphology2.40848114
10MP0002396_abnormal_hematopoietic_system2.40282234
11MP0005365_abnormal_bile_salt2.38007894
12MP0000685_abnormal_immune_system2.31900720
13MP0002102_abnormal_ear_morphology2.30745392
14MP0003763_abnormal_thymus_physiology2.23019941
15MP0001800_abnormal_humoral_immune2.18055258
16MP0004142_abnormal_muscle_tone2.08283215
17MP0009046_muscle_twitch2.07380411
18MP0003436_decreased_susceptibility_to2.07118806
19MP0005551_abnormal_eye_electrophysiolog2.03213535
20MP0003195_calcinosis2.01344639
21MP0008875_abnormal_xenobiotic_pharmacok1.99154065
22MP0001968_abnormal_touch/_nociception1.98234017
23MP0002938_white_spotting1.93536592
24MP0003252_abnormal_bile_duct1.93119284
25MP0006292_abnormal_olfactory_placode1.87205984
26MP0004133_heterotaxia1.87137024
27MP0010234_abnormal_vibrissa_follicle1.86063007
28MP0010329_abnormal_lipoprotein_level1.82085726
29MP0001790_abnormal_immune_system1.80606038
30MP0005387_immune_system_phenotype1.80606038
31MP0002398_abnormal_bone_marrow1.79431818
32MP0004808_abnormal_hematopoietic_stem1.79218849
33MP0005360_urolithiasis1.78940321
34MP0004742_abnormal_vestibular_system1.78837828
35MP0002452_abnormal_antigen_presenting1.78617301
36MP0005671_abnormal_response_to1.75839316
37MP0009745_abnormal_behavioral_response1.74116335
38MP0002837_dystrophic_cardiac_calcinosis1.73722601
39MP0002089_abnormal_postnatal_growth/wei1.73362128
40MP0006072_abnormal_retinal_apoptosis1.70873923
41MP0003705_abnormal_hypodermis_morpholog1.70738424
42MP0002928_abnormal_bile_duct1.70099927
43MP0008872_abnormal_physiological_respon1.68909157
44MP0008058_abnormal_DNA_repair1.68883840
45MP0002420_abnormal_adaptive_immunity1.66480800
46MP0002653_abnormal_ependyma_morphology1.66372901
47MP0001819_abnormal_immune_cell1.65546693
48MP0002160_abnormal_reproductive_system1.65052149
49MP0002139_abnormal_hepatobiliary_system1.63239888
50MP0005646_abnormal_pituitary_gland1.61429936
51MP0002166_altered_tumor_susceptibility1.60634613
52MP0002736_abnormal_nociception_after1.60488145
53MP0003718_maternal_effect1.57932061
54MP0002723_abnormal_immune_serum1.54473457
55MP0003693_abnormal_embryo_hatching1.53662979
56MP0003303_peritoneal_inflammation1.53647985
57MP0001873_stomach_inflammation1.53024787
58MP0004147_increased_porphyrin_level1.51908392
59MP0003787_abnormal_imprinting1.51276435
60MP0005389_reproductive_system_phenotype1.49834366
61MP0000631_abnormal_neuroendocrine_gland1.49762225
62MP0002272_abnormal_nervous_system1.49669895
63MP0001986_abnormal_taste_sensitivity1.48421948
64MP0010155_abnormal_intestine_physiology1.47561276
65MP0000716_abnormal_immune_system1.46668559
66MP0000703_abnormal_thymus_morphology1.45601844
67MP0001919_abnormal_reproductive_system1.44557449
68MP0005174_abnormal_tail_pigmentation1.44512739
69MP0002277_abnormal_respiratory_mucosa1.44245525
70MP0001764_abnormal_homeostasis1.43669522
71MP0005076_abnormal_cell_differentiation1.43647044
72MP0005464_abnormal_platelet_physiology1.43602215
73MP0001853_heart_inflammation1.40376797
74MP0010030_abnormal_orbit_morphology1.40320302
75MP0006036_abnormal_mitochondrial_physio1.39381661
76MP0004130_abnormal_muscle_cell1.39363932
77MP0004043_abnormal_pH_regulation1.38740379
78MP0005379_endocrine/exocrine_gland_phen1.37965571
79MP0000689_abnormal_spleen_morphology1.37116774
80MP0009278_abnormal_bone_marrow1.36608688
81MP0002163_abnormal_gland_morphology1.36278612
82MP0005000_abnormal_immune_tolerance1.35844022
83MP0002722_abnormal_immune_system1.34823347
84MP0005670_abnormal_white_adipose1.33848208
85MP0000609_abnormal_liver_physiology1.33674612
86MP0002064_seizures1.31676498
87MP0002419_abnormal_innate_immunity1.30955730
88MP0000049_abnormal_middle_ear1.30234634
89MP0003566_abnormal_cell_adhesion1.30113441
90MP0000371_diluted_coat_color1.28891640
91MP0003011_delayed_dark_adaptation1.28864588
92MP0004510_myositis1.28718254
93MP0002557_abnormal_social/conspecific_i1.26417182
94MP0002909_abnormal_adrenal_gland1.26354133
95MP0001486_abnormal_startle_reflex1.23334818
96MP0002429_abnormal_blood_cell1.22835316
97MP0005025_abnormal_response_to1.22236048
98MP0003698_abnormal_male_reproductive1.20992120
99MP0001485_abnormal_pinna_reflex1.19692037
100MP0006054_spinal_hemorrhage1.19494045
101MP0003119_abnormal_digestive_system1.19210134
102MP0004947_skin_inflammation1.18770614
103MP0003045_fibrosis1.18507094
104MP0001666_abnormal_nutrient_absorption1.18426011
105MP0002735_abnormal_chemical_nociception1.17735831
106MP0001529_abnormal_vocalization1.17622142
107MP0002572_abnormal_emotion/affect_behav1.16314502
108MP0006276_abnormal_autonomic_nervous1.15449282
109MP0004885_abnormal_endolymph1.15424831
110MP0002876_abnormal_thyroid_physiology1.14136481
111MP0002733_abnormal_thermal_nociception1.14061414
112MP0001970_abnormal_pain_threshold1.13915298
113MP0004145_abnormal_muscle_electrophysio1.13505395
114MP0002210_abnormal_sex_determination1.13322347
115MP0003878_abnormal_ear_physiology1.13195702
116MP0005377_hearing/vestibular/ear_phenot1.13195702
117MP0003866_abnormal_defecation1.13065809
118MP0006035_abnormal_mitochondrial_morpho1.12858849
119MP0005253_abnormal_eye_physiology1.12564176
120MP0001984_abnormal_olfaction1.09465335
121MP0000427_abnormal_hair_cycle1.09093281
122MP0001944_abnormal_pancreas_morphology1.08023886
123MP0002095_abnormal_skin_pigmentation1.07957440
124MP0005397_hematopoietic_system_phenotyp1.06571262
125MP0001545_abnormal_hematopoietic_system1.06571262
126MP0003091_abnormal_cell_migration1.05838989
127MP0000733_abnormal_muscle_development1.05497163
128MP0001929_abnormal_gametogenesis1.03629820
129MP0002751_abnormal_autonomic_nervous1.03244884
130MP0001845_abnormal_inflammatory_respons1.02396142
131MP0003136_yellow_coat_color1.01643380
132MP0002067_abnormal_sensory_capabilities1.00488214
133MP0003646_muscle_fatigue0.99947131
134MP0003880_abnormal_central_pattern0.99271778
135MP0000653_abnormal_sex_gland0.99066672
136MP0005085_abnormal_gallbladder_physiolo0.98597551
137MP0003786_premature_aging0.98311846
138MP0005220_abnormal_exocrine_pancreas0.98196678
139MP0003868_abnormal_feces_composition0.97798873
140MP0000604_amyloidosis0.97062002
141MP0001905_abnormal_dopamine_level0.96773986
142MP0005334_abnormal_fat_pad0.96610238
143MP0003635_abnormal_synaptic_transmissio0.96433145
144MP0000383_abnormal_hair_follicle0.95384753
145MP0001145_abnormal_male_reproductive0.94962739
146MP0002138_abnormal_hepatobiliary_system0.94925844
147MP0003191_abnormal_cellular_cholesterol0.94521127
148MP0005332_abnormal_amino_acid0.93845584
149MP0000955_abnormal_spinal_cord0.92936906
150MP0010094_abnormal_chromosome_stability0.91927199
151MP0002184_abnormal_innervation0.91876444
152MP0002752_abnormal_somatic_nervous0.91530918
153MP0000465_gastrointestinal_hemorrhage0.91184443
154MP0000598_abnormal_liver_morphology0.91123710
155MP0010352_gastrointestinal_tract_polyps0.90723086
156MP0000026_abnormal_inner_ear0.90473492
157MP0010630_abnormal_cardiac_muscle0.90184478
158MP0008995_early_reproductive_senescence0.90028609
159MP0002822_catalepsy0.89902131
160MP0009840_abnormal_foam_cell0.89895974
161MP0002971_abnormal_brown_adipose0.88768948
162MP0003937_abnormal_limbs/digits/tail_de0.88495656
163MP0002006_tumorigenesis0.88440911
164MP0003121_genomic_imprinting0.86809324
165MP0009763_increased_sensitivity_to0.86798355
166MP0008789_abnormal_olfactory_epithelium0.85666929
167MP0005375_adipose_tissue_phenotype0.85472133
168MP0003122_maternal_imprinting0.84467138
169MP0001293_anophthalmia0.84200409
170MP0005666_abnormal_adipose_tissue0.83972842
171MP0002405_respiratory_system_inflammati0.83885612
172MP0003656_abnormal_erythrocyte_physiolo0.83660182
173MP0002063_abnormal_learning/memory/cond0.83635287
174MP0002734_abnormal_mechanical_nocicepti0.81597396
175MP0004264_abnormal_extraembryonic_tissu0.81279509
176MP0005075_abnormal_melanosome_morpholog0.81256106
177MP0005410_abnormal_fertilization0.80782662
178MP0004859_abnormal_synaptic_plasticity0.80380854
179MP0000767_abnormal_smooth_muscle0.75827963
180MP0003943_abnormal_hepatobiliary_system0.75752001
181MP0003279_aneurysm0.74822904
182MP0000003_abnormal_adipose_tissue0.74186093
183MP0008469_abnormal_protein_level0.73882824
184MP0000751_myopathy0.73006459
185MP0002075_abnormal_coat/hair_pigmentati0.72657989
186MP0009672_abnormal_birth_weight0.72643589
187MP0005058_abnormal_lysosome_morphology0.71912207
188MP0002092_abnormal_eye_morphology0.71803495
189MP0001915_intracranial_hemorrhage0.71257625
190MP0002970_abnormal_white_adipose0.71173508
191MP0005645_abnormal_hypothalamus_physiol0.70174308
192MP0005187_abnormal_penis_morphology0.69732929
193MP0002118_abnormal_lipid_homeostasis0.69684759

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.94406312
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.94406312
3Abnormal number of erythroid precursors (HP:0012131)3.93129820
4Type II lissencephaly (HP:0007260)3.84822551
5Pancreatic cysts (HP:0001737)3.79344215
6Abnormality of cells of the erythroid lineage (HP:0012130)3.48138883
7Molar tooth sign on MRI (HP:0002419)3.45332187
8Abnormality of midbrain morphology (HP:0002418)3.45332187
9Pancreatic fibrosis (HP:0100732)3.36245332
10Congenital stationary night blindness (HP:0007642)3.31030618
11Abnormality of the fingertips (HP:0001211)3.30493785
12Nephronophthisis (HP:0000090)3.25593986
13Sclerocornea (HP:0000647)3.13130978
14Panhypogammaglobulinemia (HP:0003139)3.09713052
15Colitis (HP:0002583)3.07285547
16Abnormality of the 4th metacarpal (HP:0010012)3.05054786
17Agammaglobulinemia (HP:0004432)3.01738948
18True hermaphroditism (HP:0010459)2.96620697
19Mitochondrial inheritance (HP:0001427)2.93759013
20Macroorchidism (HP:0000053)2.92703329
21Hepatocellular necrosis (HP:0001404)2.90798665
22Cerebral aneurysm (HP:0004944)2.87343896
23Increased CSF lactate (HP:0002490)2.84418165
24Recurrent viral infections (HP:0004429)2.76293208
25Acute necrotizing encephalopathy (HP:0006965)2.75532857
26Hepatic necrosis (HP:0002605)2.75437845
27Retinal dysplasia (HP:0007973)2.73313402
28Abnormal mitochondria in muscle tissue (HP:0008316)2.71912782
29Abnormal drinking behavior (HP:0030082)2.70498289
30Polydipsia (HP:0001959)2.70498289
31Abnormality of alanine metabolism (HP:0010916)2.67798807
32Hyperalaninemia (HP:0003348)2.67798807
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67798807
34Neoplasm of the heart (HP:0100544)2.64285380
35Abnormality of the renal medulla (HP:0100957)2.63967732
36Hyperacusis (HP:0010780)2.63228664
37Acute encephalopathy (HP:0006846)2.62187857
38Ketoacidosis (HP:0001993)2.61979949
39Concave nail (HP:0001598)2.60380505
40Ketosis (HP:0001946)2.59260514
41Recurrent fungal infections (HP:0002841)2.52222262
42Hypoplasia of the pons (HP:0012110)2.51603062
43Severe muscular hypotonia (HP:0006829)2.49818308
44Chronic hepatic failure (HP:0100626)2.49768901
45Periodontitis (HP:0000704)2.48254159
46Abnormal rod and cone electroretinograms (HP:0008323)2.47958453
47Mitral stenosis (HP:0001718)2.46882842
48Attenuation of retinal blood vessels (HP:0007843)2.46792135
49Abnormality of the pons (HP:0007361)2.43975840
50Aortic aneurysm (HP:0004942)2.40530163
51Large for gestational age (HP:0001520)2.40377257
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.37603254
53Shallow orbits (HP:0000586)2.36771267
54Broad metatarsal (HP:0001783)2.36079048
55Progressive macrocephaly (HP:0004481)2.32268065
56Hypoplasia of the thymus (HP:0000778)2.30712900
57Syringomyelia (HP:0003396)2.30035546
58Spinal cord lesions (HP:0100561)2.30035546
59Cerebellar dysplasia (HP:0007033)2.29637806
60Hyperthyroidism (HP:0000836)2.27943532
61Elfin facies (HP:0004428)2.27866444
62Gastrointestinal inflammation (HP:0004386)2.27604223
63Increased density of long bones (HP:0006392)2.26079214
64Cystic liver disease (HP:0006706)2.25184524
65B lymphocytopenia (HP:0010976)2.25157542
66Abnormality of B cell number (HP:0010975)2.25157542
67Polyuria (HP:0000103)2.24468779
68Type 2 muscle fiber atrophy (HP:0003554)2.24239701
69Increased serum lactate (HP:0002151)2.23788476
70Narrow palate (HP:0000189)2.22618651
71Elevated erythrocyte sedimentation rate (HP:0003565)2.22048135
72Pendular nystagmus (HP:0012043)2.21465218
73Lactic acidosis (HP:0003128)2.21198074
74Congenital malformation of the right heart (HP:0011723)2.21167468
75Double outlet right ventricle (HP:0001719)2.21167468
76Rib fusion (HP:0000902)2.19579751
77Long toe (HP:0010511)2.19113368
78Abnormality of the renal cortex (HP:0011035)2.17892065
79Inflammation of the large intestine (HP:0002037)2.17100479
80Hepatoblastoma (HP:0002884)2.17038292
81Bile duct proliferation (HP:0001408)2.15962268
82Abnormal biliary tract physiology (HP:0012439)2.15962268
833-Methylglutaconic aciduria (HP:0003535)2.14214742
84Medial flaring of the eyebrow (HP:0010747)2.12956387
85Birth length less than 3rd percentile (HP:0003561)2.12942295
86Hypoplasia of the uterus (HP:0000013)2.10672407
87Chest pain (HP:0100749)2.10397566
88Cerebral edema (HP:0002181)2.09447571
89Ureteral stenosis (HP:0000071)2.09277705
90Absent frontal sinuses (HP:0002688)2.08948952
91Hyperglycinuria (HP:0003108)2.08250433
92Methylmalonic aciduria (HP:0012120)2.07676399
93Patellar aplasia (HP:0006443)2.07332757
94Obsessive-compulsive behavior (HP:0000722)2.05898986
95Truncus arteriosus (HP:0001660)2.04893263
96Aplasia/Hypoplasia of the uvula (HP:0010293)2.04474989
97Hemiplegia (HP:0002301)2.04320570
98Thin bony cortex (HP:0002753)2.03912558
99Long eyelashes (HP:0000527)2.03282230
100Tubular atrophy (HP:0000092)2.02328097
101Recurrent bacterial skin infections (HP:0005406)2.01992123
102Muscle fiber atrophy (HP:0100295)2.00832239
103Lissencephaly (HP:0001339)1.99804787
104Mitral valve prolapse (HP:0001634)1.99799620
105Aplasia/Hypoplasia of the patella (HP:0006498)1.99673257
106Optic disc pallor (HP:0000543)1.99006989
107Broad face (HP:0000283)1.98957331
108Heterotopia (HP:0002282)1.98872739
109Cellulitis (HP:0100658)1.96894515
110Aplasia/hypoplasia of the uterus (HP:0008684)1.96370129
111Viral hepatitis (HP:0006562)1.95777055
112Anal stenosis (HP:0002025)1.95408373
113Renovascular hypertension (HP:0100817)1.95370605
114Abnormal protein glycosylation (HP:0012346)1.95151957
115Abnormal glycosylation (HP:0012345)1.95151957
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95151957
117Abnormal protein N-linked glycosylation (HP:0012347)1.95151957
118Type I transferrin isoform profile (HP:0003642)1.94722016
119Vertebral arch anomaly (HP:0008438)1.93650674
120Lymphangioma (HP:0100764)1.91897216
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.91863505
122Abnormality of DNA repair (HP:0003254)1.90251423
123Absent/shortened dynein arms (HP:0200106)1.89570943
124Dynein arm defect of respiratory motile cilia (HP:0012255)1.89570943
125Recurrent bronchitis (HP:0002837)1.89520793
126Lipid accumulation in hepatocytes (HP:0006561)1.89272295
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.88991539
128Decreased circulating renin level (HP:0003351)1.88174898
129Aneurysm (HP:0002617)1.87408998
130Chronic mucocutaneous candidiasis (HP:0002728)1.87034391
131Recurrent cutaneous fungal infections (HP:0011370)1.87034391
132Amelogenesis imperfecta (HP:0000705)1.86635894
133Limb hypertonia (HP:0002509)1.85915500
134Colon cancer (HP:0003003)1.84575318
135Duplicated collecting system (HP:0000081)1.84425474
136Abnormal delayed hypersensitivity skin test (HP:0002963)1.84156750
137Radial bowing (HP:0002986)1.83852436
138Thrombocytosis (HP:0001894)1.83739212
139Abnormality of the thoracic spine (HP:0100711)1.83365660
140Occipital encephalocele (HP:0002085)1.83047232
141Congenital hepatic fibrosis (HP:0002612)1.82928814
142Verrucae (HP:0200043)1.82215736
143Papilloma (HP:0012740)1.82215736
144Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81101072
145Hematochezia (HP:0002573)1.80880012
146Male pseudohermaphroditism (HP:0000037)1.80735660
147Microretrognathia (HP:0000308)1.79430086
148Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78948369
149Dicarboxylic aciduria (HP:0003215)1.78948369
150Pustule (HP:0200039)1.78928464
151Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77530836
152Ureteral obstruction (HP:0006000)1.76568718
153Microvesicular hepatic steatosis (HP:0001414)1.75194165
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75102816
155Trigonocephaly (HP:0000243)1.74729330
156Myocardial infarction (HP:0001658)1.74333225
157Abnormality of the renal collecting system (HP:0004742)1.73683582
158Gingival bleeding (HP:0000225)1.73585880
159Recurrent abscess formation (HP:0002722)1.73418129
160Progressive cerebellar ataxia (HP:0002073)1.73249330
161Hyperventilation (HP:0002883)1.73237092
162Bulbous nose (HP:0000414)1.73164459
163Deep venous thrombosis (HP:0002625)1.72856033
164Increased hepatocellular lipid droplets (HP:0006565)1.72742573
165Tetany (HP:0001281)1.72561224
166Gastrointestinal stroma tumor (HP:0100723)1.72294867
167Increased corneal curvature (HP:0100692)1.72158668
168Keratoconus (HP:0000563)1.72158668
169Abnormal urine output (HP:0012590)1.71117672
170T lymphocytopenia (HP:0005403)1.70691541
171Aplasia/Hypoplasia of the spleen (HP:0010451)1.70592769
172Neoplasm of the adrenal cortex (HP:0100641)1.70394817
173Severe short stature (HP:0003510)1.70388809
174Arterial thrombosis (HP:0004420)1.68889814
175Disproportionate tall stature (HP:0001519)1.68759090
176Lymphopenia (HP:0001888)1.67902878
177Bicuspid aortic valve (HP:0001647)1.66489695
178Subacute progressive viral hepatitis (HP:0006572)1.65218648
179Hepatitis (HP:0012115)1.64581825
180Restrictive lung disease (HP:0002091)1.64441054
181Abnormality of cells of the lymphoid lineage (HP:0012140)1.62882522
182Abnormality of the peritoneum (HP:0002585)1.61600537
183Dilatation of the ascending aorta (HP:0005111)1.61520572
184Gingivitis (HP:0000230)1.60798095
185Pointed chin (HP:0000307)1.60365801
186Abnormality of the metopic suture (HP:0005556)1.59253824
187Eczematoid dermatitis (HP:0000976)1.58416068
188Myositis (HP:0100614)1.58343581
189Prolonged bleeding time (HP:0003010)1.58240478
190Autoimmune thrombocytopenia (HP:0001973)1.57780214
191Abnormality of oral frenula (HP:0000190)1.57517578
192Emphysema (HP:0002097)1.56757336
193Recurrent skin infections (HP:0001581)1.56685508
194Thoracic kyphosis (HP:0002942)1.56393615
195Frequent falls (HP:0002359)1.55168389
196Broad hallux (HP:0010055)1.54329467
197Hypoplastic labia majora (HP:0000059)1.54072618
198Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.53105023
199Pseudobulbar signs (HP:0002200)1.52974007
200Skin tags (HP:0010609)1.52297938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.53375595
2SIK23.48301260
3VRK23.20621827
4SIK13.12870699
5ZAK3.09826802
6ADRBK22.89729638
7TLK12.87306363
8ERN12.85071426
9NUAK12.80606820
10PKN22.73774810
11MAP3K132.70094064
12TAF12.68266425
13CDK122.65873831
14CAMK1G2.65160725
15STK162.53688559
16MAP4K12.51560918
17MAP4K22.43382253
18PNCK2.40597292
19TYK22.37038000
20GRK12.31788690
21MAP3K102.30290618
22BCKDK2.27289658
23BMPR1B2.23534153
24EEF2K2.23227483
25WNK42.17976169
26TGFBR22.17491729
27VRK11.91394896
28PINK11.89141195
29FGFR41.87511711
30TTN1.84769782
31TRIB31.83474960
32CAMK1D1.82717963
33BRD41.78511160
34SIK31.70991015
35MAP2K71.67275812
36JAK31.65755101
37DYRK21.62144792
38INSRR1.59288701
39MAP3K71.55663254
40JAK11.54880786
41TAOK31.54033293
42MAPK131.50017213
43CASK1.44149267
44CSF1R1.41639168
45FLT31.39282742
46NME21.36839573
47PTK61.36072114
48MAP3K41.33092129
49NTRK31.21846353
50DYRK31.20704132
51ZAP701.17606729
52ACVR1B1.16643539
53CSNK1G31.13163116
54CSNK1G11.12437557
55GRK61.11601344
56MUSK1.10296564
57BTK1.09350919
58CDK81.08431345
59LMTK21.07318482
60PDGFRB1.05729986
61NME11.05515878
62MAP2K21.04614678
63HCK1.04221637
64CSNK1G21.04110842
65PDGFRA1.03621512
66TNIK1.03196483
67ERBB31.00198303
68MAP3K90.99802994
69RIPK40.97995849
70IKBKB0.96942773
71OXSR10.96092027
72BUB10.95797328
73PRKCG0.95010656
74WNK30.94704528
75MKNK20.94602724
76MAPKAPK50.93902383
77CDK60.92916709
78RPS6KA50.92894498
79ITK0.92582461
80MAP3K140.91868489
81FGFR30.89747742
82MAPKAPK30.89623205
83MTOR0.89355795
84RET0.89038713
85NEK20.88797378
86RPS6KA60.88404867
87DYRK1B0.88326976
88ADRBK10.87476345
89STK100.87444173
90SYK0.87416899
91IRAK30.86928462
92CHEK20.86406926
93KIT0.86138652
94JAK20.86020641
95RIPK10.83422293
96WEE10.83355601
97STK390.81541656
98IKBKE0.76283980
99PASK0.75867453
100CHUK0.74592823
101MARK10.73582082
102SGK30.73481099
103CDC70.72224663
104PTK2B0.72111377
105PRKCI0.71495800
106MARK30.70058175
107MARK20.69560732
108PRKCH0.68512602
109PIM20.68345955
110PLK40.67337562
111TBK10.66730758
112STK110.66727872
113TGFBR10.66652269
114ERBB20.65303800
115CDC42BPA0.65250918
116CAMKK20.64782465
117RPS6KA20.64450479
118DAPK20.63572313
119CAMK40.63403785
120MAPK150.62645409
121LRRK20.62573373
122TNK20.61812406
123CAMK10.61716281
124BRSK20.61384008
125MKNK10.61000887
126PAK30.60573882
127PRKD30.60537934
128KSR20.59492297
129TAOK10.59285575
130PLK30.58666763
131YES10.58289584
132MAPK110.57448964
133TYRO30.56981000
134SGK20.56932927
135LCK0.55785024
136MAPK120.54782320
137IRAK40.54559858
138HIPK20.54326813
139CSNK1A10.53273130
140DYRK1A0.51072988
141GRK50.50036555
142CSNK1A1L0.49739874
143CDK40.49702328
144MAP2K60.49675544
145PRKCE0.49134263
146CSK0.48558220
147DMPK0.48169778
148PTK20.47824137
149LYN0.47488814
150ABL20.47175715
151RPS6KC10.46606622
152RPS6KL10.46606622
153AURKA0.45825822
154FES0.44493969
155DAPK10.43666344
156PLK10.43402576
157PKN10.43222795
158RPS6KB20.42780451
159NEK90.42776240
160ICK0.41690872
161PHKG20.40359917
162PHKG10.40359917
163FGFR20.40321997
164NTRK20.39896208
165TRIM280.39723946
166PRKCZ0.39526764
167PDK10.38953190
168ATR0.38886500
169CAMKK10.38852522
170KSR10.38456584
171PRKAA10.38126109
172PRKAA20.38079201
173TXK0.36669179
174MAPK70.36621849
175TEC0.36532486
176LATS10.35811022
177MAP2K40.33848580
178BRAF0.32842615
179CSNK2A10.32216062
180PRKACA0.31029954
181ATM0.30543926
182CAMK2D0.30535274

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.35663114
2Oxidative phosphorylation_Homo sapiens_hsa001902.87896680
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.85789421
4Ribosome_Homo sapiens_hsa030102.74733974
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.66340110
6Homologous recombination_Homo sapiens_hsa034402.48383534
7Selenocompound metabolism_Homo sapiens_hsa004502.46154397
8Fanconi anemia pathway_Homo sapiens_hsa034602.35381443
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33114469
10Parkinsons disease_Homo sapiens_hsa050122.32743103
11Primary immunodeficiency_Homo sapiens_hsa053402.27800052
12Lysine degradation_Homo sapiens_hsa003102.24359421
13B cell receptor signaling pathway_Homo sapiens_hsa046622.18573231
14RNA polymerase_Homo sapiens_hsa030202.13153896
15Linoleic acid metabolism_Homo sapiens_hsa005911.99559374
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.93985853
17Caffeine metabolism_Homo sapiens_hsa002321.91823506
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89339773
19Basal transcription factors_Homo sapiens_hsa030221.88860337
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.86423294
21Butanoate metabolism_Homo sapiens_hsa006501.81589245
22Insulin resistance_Homo sapiens_hsa049311.75989472
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.72717539
24Phototransduction_Homo sapiens_hsa047441.69865802
25Type II diabetes mellitus_Homo sapiens_hsa049301.66561726
26Huntingtons disease_Homo sapiens_hsa050161.62531402
27Base excision repair_Homo sapiens_hsa034101.62049639
28Nucleotide excision repair_Homo sapiens_hsa034201.55027314
29Alzheimers disease_Homo sapiens_hsa050101.52033283
30One carbon pool by folate_Homo sapiens_hsa006701.50919100
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48169927
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.47560437
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46856608
34Mismatch repair_Homo sapiens_hsa034301.46664177
35Cardiac muscle contraction_Homo sapiens_hsa042601.45502343
36Osteoclast differentiation_Homo sapiens_hsa043801.45119319
37Chronic myeloid leukemia_Homo sapiens_hsa052201.44940199
38DNA replication_Homo sapiens_hsa030301.43798012
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.38902427
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36030161
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35372888
42Pyrimidine metabolism_Homo sapiens_hsa002401.35279105
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.35112630
44Notch signaling pathway_Homo sapiens_hsa043301.34925667
45Sulfur metabolism_Homo sapiens_hsa009201.34752744
46RNA degradation_Homo sapiens_hsa030181.33688467
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33619922
48Ether lipid metabolism_Homo sapiens_hsa005651.33111479
49Protein export_Homo sapiens_hsa030601.32753888
50Nicotine addiction_Homo sapiens_hsa050331.32575906
51Acute myeloid leukemia_Homo sapiens_hsa052211.29568535
52ABC transporters_Homo sapiens_hsa020101.28872561
53mTOR signaling pathway_Homo sapiens_hsa041501.28607851
54T cell receptor signaling pathway_Homo sapiens_hsa046601.27530372
55Staphylococcus aureus infection_Homo sapiens_hsa051501.27517334
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26435895
57Leishmaniasis_Homo sapiens_hsa051401.22778597
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.20199112
59Purine metabolism_Homo sapiens_hsa002301.18188569
60Peroxisome_Homo sapiens_hsa041461.17819132
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17767594
62Viral myocarditis_Homo sapiens_hsa054161.17334234
63Nitrogen metabolism_Homo sapiens_hsa009101.16114216
64Insulin signaling pathway_Homo sapiens_hsa049101.15744995
65Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15545761
66Measles_Homo sapiens_hsa051621.13722080
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12343755
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11701783
69Primary bile acid biosynthesis_Homo sapiens_hsa001201.08174806
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07733571
71Adipocytokine signaling pathway_Homo sapiens_hsa049201.07245298
72Non-homologous end-joining_Homo sapiens_hsa034501.06959867
73Non-small cell lung cancer_Homo sapiens_hsa052231.05846322
74Toxoplasmosis_Homo sapiens_hsa051451.05578849
75Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05244299
76Arachidonic acid metabolism_Homo sapiens_hsa005901.04779772
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04256325
78Influenza A_Homo sapiens_hsa051641.04193562
79Platelet activation_Homo sapiens_hsa046111.03303333
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03271631
81Chemokine signaling pathway_Homo sapiens_hsa040621.02281471
82Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02058553
83Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01307726
84Propanoate metabolism_Homo sapiens_hsa006401.00862727
85Herpes simplex infection_Homo sapiens_hsa051680.97571530
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96303380
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95137850
88Glucagon signaling pathway_Homo sapiens_hsa049220.93741881
89Endometrial cancer_Homo sapiens_hsa052130.92836655
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92349321
91Prolactin signaling pathway_Homo sapiens_hsa049170.91567611
92Hepatitis B_Homo sapiens_hsa051610.91249709
93Bile secretion_Homo sapiens_hsa049760.91232868
94Complement and coagulation cascades_Homo sapiens_hsa046100.88977455
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88436575
96Taste transduction_Homo sapiens_hsa047420.88374378
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.87048068
98Colorectal cancer_Homo sapiens_hsa052100.86699445
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86695331
100Regulation of autophagy_Homo sapiens_hsa041400.86112711
101AMPK signaling pathway_Homo sapiens_hsa041520.85128194
102Metabolic pathways_Homo sapiens_hsa011000.85100748
103Pancreatic cancer_Homo sapiens_hsa052120.84563949
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81054921
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79759222
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78638871
107VEGF signaling pathway_Homo sapiens_hsa043700.75801245
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75507474
109Proteasome_Homo sapiens_hsa030500.75501200
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75155314
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.75154815
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.74816095
113Small cell lung cancer_Homo sapiens_hsa052220.74065519
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.73890960
115Choline metabolism in cancer_Homo sapiens_hsa052310.73672946
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73193179
117Other glycan degradation_Homo sapiens_hsa005110.72810197
118RNA transport_Homo sapiens_hsa030130.72747803
119Fatty acid degradation_Homo sapiens_hsa000710.72564868
120Apoptosis_Homo sapiens_hsa042100.72131953
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.71919218
122Starch and sucrose metabolism_Homo sapiens_hsa005000.71902523
123Proteoglycans in cancer_Homo sapiens_hsa052050.70771429
124Hepatitis C_Homo sapiens_hsa051600.70736635
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70706947
126FoxO signaling pathway_Homo sapiens_hsa040680.70427434
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70123296
128TNF signaling pathway_Homo sapiens_hsa046680.69690054
129PPAR signaling pathway_Homo sapiens_hsa033200.68626239
130Tuberculosis_Homo sapiens_hsa051520.67590688
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67310564
132Spliceosome_Homo sapiens_hsa030400.66886410
133GnRH signaling pathway_Homo sapiens_hsa049120.66808657
134Morphine addiction_Homo sapiens_hsa050320.66649514
135Arginine biosynthesis_Homo sapiens_hsa002200.63748470
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63292820
137Chemical carcinogenesis_Homo sapiens_hsa052040.61322825
138Shigellosis_Homo sapiens_hsa051310.60736905
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.59994578
140Ovarian steroidogenesis_Homo sapiens_hsa049130.59987764
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59941737
142Glioma_Homo sapiens_hsa052140.58391806
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58072290
144Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57840277
145Tryptophan metabolism_Homo sapiens_hsa003800.57813803
146HTLV-I infection_Homo sapiens_hsa051660.57013669
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56481269
148Vitamin B6 metabolism_Homo sapiens_hsa007500.55322442
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55226068
150Long-term potentiation_Homo sapiens_hsa047200.55027873
151Olfactory transduction_Homo sapiens_hsa047400.53986883
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53596669
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53380605
154ErbB signaling pathway_Homo sapiens_hsa040120.53253314
155Asthma_Homo sapiens_hsa053100.53072805
156Vitamin digestion and absorption_Homo sapiens_hsa049770.52975198
157MicroRNAs in cancer_Homo sapiens_hsa052060.52708194
158Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52562564
159Basal cell carcinoma_Homo sapiens_hsa052170.51534199
160Collecting duct acid secretion_Homo sapiens_hsa049660.51143927
161Glutathione metabolism_Homo sapiens_hsa004800.50801004
162Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50392479
163Focal adhesion_Homo sapiens_hsa045100.50359770
164Steroid biosynthesis_Homo sapiens_hsa001000.50275863
165Insulin secretion_Homo sapiens_hsa049110.49914625
166N-Glycan biosynthesis_Homo sapiens_hsa005100.49816308
167Oxytocin signaling pathway_Homo sapiens_hsa049210.48764881
168Hematopoietic cell lineage_Homo sapiens_hsa046400.48638924
169Fat digestion and absorption_Homo sapiens_hsa049750.47219279
170Fatty acid elongation_Homo sapiens_hsa000620.47160776
171beta-Alanine metabolism_Homo sapiens_hsa004100.46488764
172Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45400794
173Inositol phosphate metabolism_Homo sapiens_hsa005620.45342848
174cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45312925
175Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43911037
176Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43111136
177Retinol metabolism_Homo sapiens_hsa008300.40202431
178Arginine and proline metabolism_Homo sapiens_hsa003300.39171927
179Hedgehog signaling pathway_Homo sapiens_hsa043400.38352646
180Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37594268
181Folate biosynthesis_Homo sapiens_hsa007900.37305338
182Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36482983
183Serotonergic synapse_Homo sapiens_hsa047260.35963282
184Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35577144
185Glutamatergic synapse_Homo sapiens_hsa047240.33951146
186Glycerolipid metabolism_Homo sapiens_hsa005610.33592367
187Fatty acid metabolism_Homo sapiens_hsa012120.29603179

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