ANKRD13D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the ankyrin repeat domain (ANKRD) 13 family, which currently consists of four proteins containing ubiquitin-interacting motifs. These proteins are integral membrane proteins that bind specifically to Lys-63-linked ubiquitin chains on membrane-bound proteins, targeting those proteins for rapid internalization. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.28742203
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.21938255
3negative regulation of cell killing (GO:0031342)6.21938255
4synaptic vesicle maturation (GO:0016188)6.05598098
5positive regulation of gamma-delta T cell activation (GO:0046645)5.90396702
6synaptic vesicle exocytosis (GO:0016079)5.70852382
7locomotory exploration behavior (GO:0035641)5.64865560
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.56218649
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51069594
10antigen processing and presentation of endogenous antigen (GO:0019883)5.35092247
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.33997543
12regulation of synaptic vesicle exocytosis (GO:2000300)5.19699250
13vocalization behavior (GO:0071625)5.19535856
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.18134752
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17576154
16glutamate secretion (GO:0014047)5.05940880
17neutrophil activation involved in immune response (GO:0002283)5.04775537
18positive regulation by symbiont of host defense response (GO:0052509)5.02679059
19modulation by symbiont of host defense response (GO:0052031)5.02679059
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.02679059
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.02679059
22positive regulation by organism of defense response of other organism involved in symbiotic interact5.02679059
23modulation by symbiont of host immune response (GO:0052553)5.02679059
24protein localization to synapse (GO:0035418)4.91768211
25regulation of glutamate receptor signaling pathway (GO:1900449)4.89918921
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88244836
27detection of other organism (GO:0098543)4.68792211
28neuron cell-cell adhesion (GO:0007158)4.68326562
29neuronal action potential propagation (GO:0019227)4.67950467
30regulation of B cell receptor signaling pathway (GO:0050855)4.67170232
31detection of bacterium (GO:0016045)4.63236468
32regulation of synaptic vesicle transport (GO:1902803)4.62975923
33response to peptidoglycan (GO:0032494)4.60351235
34leukocyte aggregation (GO:0070486)4.59227278
35exploration behavior (GO:0035640)4.55700607
36neurotransmitter secretion (GO:0007269)4.51376853
37ionotropic glutamate receptor signaling pathway (GO:0035235)4.51160846
38layer formation in cerebral cortex (GO:0021819)4.48667768
39cellular extravasation (GO:0045123)4.31572366
40regulation of gamma-delta T cell activation (GO:0046643)4.30507428
41macrophage activation involved in immune response (GO:0002281)4.28485637
42regulation of neuronal synaptic plasticity (GO:0048168)4.27230382
43regulation of synapse structural plasticity (GO:0051823)4.25951252
44synaptic vesicle docking involved in exocytosis (GO:0016081)4.24886596
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.23261849
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15183194
47negative regulation of erythrocyte differentiation (GO:0045647)4.14743994
48negative regulation of lymphocyte mediated immunity (GO:0002707)4.14408053
49regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11921969
50proline transport (GO:0015824)4.10882511
51dendritic spine morphogenesis (GO:0060997)4.05894289
52neutrophil activation (GO:0042119)4.04720107
53positive thymic T cell selection (GO:0045059)3.99638617
54synaptic transmission, glutamatergic (GO:0035249)3.99581918
55glutamate receptor signaling pathway (GO:0007215)3.96667478
56regulation of gamma-delta T cell differentiation (GO:0045586)3.91895162
57response to muramyl dipeptide (GO:0032495)3.86010501
58negative regulation of interleukin-12 production (GO:0032695)3.85224757
59negative thymic T cell selection (GO:0045060)3.82857532
60regulation of mast cell degranulation (GO:0043304)3.79851013
61detection of external biotic stimulus (GO:0098581)3.75095368
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.75080148
63neuron-neuron synaptic transmission (GO:0007270)3.74659696
64negative regulation of leukocyte mediated immunity (GO:0002704)3.74200728
65respiratory burst (GO:0045730)3.73520161
66negative regulation of T cell mediated immunity (GO:0002710)3.72835722
67negative T cell selection (GO:0043383)3.72778725
68activated T cell proliferation (GO:0050798)3.69634845
69immunoglobulin mediated immune response (GO:0016064)3.68958350
70synaptic vesicle endocytosis (GO:0048488)3.68145125
71neuron recognition (GO:0008038)3.68052853
72cellular potassium ion homeostasis (GO:0030007)3.65250359
73gamma-aminobutyric acid transport (GO:0015812)3.65030045
74B cell receptor signaling pathway (GO:0050853)3.64862051
75granulocyte activation (GO:0036230)3.63947258
76neurotransmitter transport (GO:0006836)3.62509487
77regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.59996686
78leukocyte migration involved in inflammatory response (GO:0002523)3.59863675
79positive regulation of synapse maturation (GO:0090129)3.59593924
80regulation of myeloid leukocyte mediated immunity (GO:0002886)3.59501633
81long-term memory (GO:0007616)3.58273565
82positive regulation of membrane potential (GO:0045838)3.58216640
83response to interleukin-15 (GO:0070672)3.57054832
84regulation of B cell differentiation (GO:0045577)3.56356552
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55532079
86positive regulation of B cell differentiation (GO:0045579)3.55421469
87neurotransmitter-gated ion channel clustering (GO:0072578)3.55342937
88positive regulation of mast cell activation (GO:0033005)3.55334722
89activation of protein kinase A activity (GO:0034199)3.55309627
90regulation of interferon-beta biosynthetic process (GO:0045357)3.55010017
91myeloid cell activation involved in immune response (GO:0002275)3.54157752
92response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.53797729
93response to host immune response (GO:0052572)3.53797729
94regulation of excitatory postsynaptic membrane potential (GO:0060079)3.53070569
95membrane depolarization during action potential (GO:0086010)3.52522884
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.51422647
97regulation of mast cell activation involved in immune response (GO:0033006)3.48376677
98tolerance induction (GO:0002507)3.45846481
99axonal fasciculation (GO:0007413)3.45628979
100sodium ion export (GO:0071436)3.45521370
101regulation of vesicle fusion (GO:0031338)3.45489798
102regulation of mast cell activation (GO:0033003)3.43623465
103T cell selection (GO:0045058)3.43302839
104negative regulation of microtubule polymerization (GO:0031115)3.42627258
105positive T cell selection (GO:0043368)3.42575430
106regulation of leukocyte degranulation (GO:0043300)3.42129093
107microglial cell activation (GO:0001774)3.42109574
108positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.42104256
109neutrophil mediated immunity (GO:0002446)3.42051680
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.41657455
111innervation (GO:0060384)3.40266556
112regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39866307
113transmission of nerve impulse (GO:0019226)3.39278419
114auditory behavior (GO:0031223)3.38380242
115neuromuscular process controlling posture (GO:0050884)3.37911228
116cerebellar Purkinje cell differentiation (GO:0021702)3.37450886
117regulation of neurotransmitter levels (GO:0001505)3.37297112
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.37210564
119detection of biotic stimulus (GO:0009595)3.36955916
120gamma-aminobutyric acid signaling pathway (GO:0007214)3.36631457
121regulation of postsynaptic membrane potential (GO:0060078)3.36548293
122regulation of synaptic plasticity (GO:0048167)3.35812802
123postsynaptic membrane organization (GO:0001941)3.33782097
124regulation of neurotransmitter secretion (GO:0046928)3.33588570
125antigen processing and presentation via MHC class Ib (GO:0002475)3.31738126
126thymic T cell selection (GO:0045061)3.31689689
127negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31240174
128response to auditory stimulus (GO:0010996)3.30876368
129leukocyte degranulation (GO:0043299)3.29736105
130neuromuscular process controlling balance (GO:0050885)3.28805200
131negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27281454
132cellular response to interleukin-15 (GO:0071350)3.24695768
133negative regulation of dendrite morphogenesis (GO:0050774)3.24028469
134cell migration in hindbrain (GO:0021535)3.23686045
135response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23091219
136response to host (GO:0075136)3.23091219
137response to host defenses (GO:0052200)3.23091219
138negative regulation of phagocytosis (GO:0050765)3.21817100
139macrophage activation (GO:0042116)3.21693810
140dendrite morphogenesis (GO:0048813)3.20336328
141G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20320588
142membrane depolarization (GO:0051899)3.18725410
143mannose metabolic process (GO:0006013)3.18505263
144regulation of dendritic spine morphogenesis (GO:0061001)3.18362511
145negative regulation of interleukin-6 production (GO:0032715)3.17970244
146vesicle transport along microtubule (GO:0047496)3.16987347
147positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16500308
148regulation of tolerance induction (GO:0002643)3.16440982
149long-term synaptic potentiation (GO:0060291)3.16353745
150detection of molecule of bacterial origin (GO:0032490)3.15254816
151negative regulation of dendrite development (GO:2000171)3.13785856
152positive regulation of mast cell activation involved in immune response (GO:0033008)3.13194326
153positive regulation of mast cell degranulation (GO:0043306)3.13194326
154regulation of synaptic transmission, glutamatergic (GO:0051966)3.13180907
155germinal center formation (GO:0002467)3.13056372
156defense response to protozoan (GO:0042832)3.10383879
157synapse assembly (GO:0007416)3.10002629
158cell communication by electrical coupling (GO:0010644)3.09272926
159regulation of regulated secretory pathway (GO:1903305)3.09209256
160regulation of T cell tolerance induction (GO:0002664)3.08197464
161cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07708906
162axon cargo transport (GO:0008088)3.07428281
163response to pheromone (GO:0019236)3.05348821
164organelle transport along microtubule (GO:0072384)3.04483203
165regulation of neurotransmitter transport (GO:0051588)3.04187422
166positive regulation of dendritic spine development (GO:0060999)3.03507761
167negative regulation of innate immune response (GO:0045824)3.02467319
168membrane hyperpolarization (GO:0060081)3.02330638
169response to type I interferon (GO:0034340)3.01085858
170myeloid leukocyte mediated immunity (GO:0002444)2.99238067
171type I interferon signaling pathway (GO:0060337)2.97029474
172cellular response to type I interferon (GO:0071357)2.97029474
173T cell migration (GO:0072678)2.96876102
174positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96715480
175establishment of synaptic vesicle localization (GO:0097480)2.94981783
176synaptic vesicle transport (GO:0048489)2.94981783
177neuronal ion channel clustering (GO:0045161)2.94920676
178learning (GO:0007612)2.94621926
179synaptic transmission (GO:0007268)2.94529933
180negative regulation of T-helper cell differentiation (GO:0045623)2.93709305
181negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93709305
182behavioral fear response (GO:0001662)2.93258753
183behavioral defense response (GO:0002209)2.93258753
184regulation of alpha-beta T cell proliferation (GO:0046640)2.93089940
185regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92951889
186regulation of natural killer cell mediated immunity (GO:0002715)2.92951889
187regulation of synaptic transmission (GO:0050804)2.91542274
188regulation of T cell mediated cytotoxicity (GO:0001914)2.91023373
189neuromuscular process (GO:0050905)2.89681744
190positive regulation of synaptic transmission (GO:0050806)2.89225708
191positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88883546
192response to protozoan (GO:0001562)2.88069715
193positive regulation of potassium ion transmembrane transport (GO:1901381)2.87842823
194mechanosensory behavior (GO:0007638)2.87330838
195prepulse inhibition (GO:0060134)2.87310357
196intraspecies interaction between organisms (GO:0051703)2.87216493
197positive regulation of granulocyte differentiation (GO:0030854)2.86471260
198mast cell activation (GO:0045576)2.81816989
199positive regulation of antigen processing and presentation (GO:0002579)2.81144735

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.97306904
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.76611295
3* VDR_21846776_ChIP-Seq_THP-1_Human3.74546231
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.59180779
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.26735340
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23493897
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.23472354
8GBX2_23144817_ChIP-Seq_PC3_Human3.19077172
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.17081916
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05674482
11REST_21632747_ChIP-Seq_MESCs_Mouse3.03216567
12* VDR_24763502_ChIP-Seq_THP-1_Human3.02360118
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.95004244
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.85798216
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79482726
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79482726
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.76573743
18MYC_22102868_ChIP-Seq_BL_Human2.74007938
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.70623321
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.69598811
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66262048
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65191187
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.64702127
24* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63724103
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61863713
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61351007
27EZH2_27304074_Chip-Seq_ESCs_Mouse2.61268660
28REST_18959480_ChIP-ChIP_MESCs_Mouse2.56236435
29DROSHA_22980978_ChIP-Seq_HELA_Human2.53218113
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.51253732
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51243822
32RUNX_20019798_ChIP-Seq_JUKART_Human2.49929970
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.46489892
34SUZ12_27294783_Chip-Seq_ESCs_Mouse2.46248911
35* MAF_26560356_Chip-Seq_TH1_Human2.44934490
36SCL_19346495_ChIP-Seq_HPC-7_Human2.42165140
37EZH2_27294783_Chip-Seq_ESCs_Mouse2.42124766
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38361258
39* UTX_26944678_Chip-Seq_JUKART_Human2.36906249
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.31433264
41MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29891523
42SPI1_23547873_ChIP-Seq_NB4_Human2.28981055
43TCF7_22412390_ChIP-Seq_EML_Mouse2.27276509
44RNF2_27304074_Chip-Seq_ESCs_Mouse2.26687896
45* KDM2B_26808549_Chip-Seq_DND41_Human2.26278053
46RUNX1_22412390_ChIP-Seq_EML_Mouse2.24370548
47SPI1_23127762_ChIP-Seq_K562_Human2.23075757
48EED_16625203_ChIP-ChIP_MESCs_Mouse2.22761073
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22387562
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21454099
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17033790
52MYB_26560356_Chip-Seq_TH2_Human2.08826107
53* MAF_26560356_Chip-Seq_TH2_Human2.07703473
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06775179
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04967837
56* LXR_22292898_ChIP-Seq_THP-1_Human1.99199531
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98849691
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97683730
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96201694
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95697105
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94289703
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93694946
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92068507
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91498596
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89919781
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88175985
67* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.87683868
68MYB_26560356_Chip-Seq_TH1_Human1.86921132
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.80585771
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80471418
71* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73842649
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.70498349
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65517349
74ZNF274_21170338_ChIP-Seq_K562_Hela1.65017255
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64215347
76AR_21572438_ChIP-Seq_LNCaP_Human1.62390432
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.61803072
78TAF15_26573619_Chip-Seq_HEK293_Human1.61489472
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.56141003
80BCL6_27268052_Chip-Seq_Bcells_Human1.55417660
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53589419
82GATA3_27048872_Chip-Seq_THYMUS_Human1.53530043
83* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.51632162
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51429608
85* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50536834
86VDR_24787735_ChIP-Seq_THP-1_Human1.47689605
87SMAD4_21799915_ChIP-Seq_A2780_Human1.43719274
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.41997977
89* BCOR_27268052_Chip-Seq_Bcells_Human1.41723628
90* P68_20966046_ChIP-Seq_HELA_Human1.41135777
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.40480793
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40200105
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39520523
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38324117
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38050990
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37765645
97ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37292568
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37142777
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34182737
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32780669
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32623498
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32074493
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.31796500
104EGR1_19374776_ChIP-ChIP_THP-1_Human1.31684904
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29530628
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28096460
107* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27246497
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.26666710
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26426555
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25841439
111* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25516976
112CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25368054
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24034138
114* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24023202
115KDM2B_26808549_Chip-Seq_K562_Human1.23887180
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.22540458
117* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22481459
118* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22203464
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21387959
120VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.20131845
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19339214
122AR_25329375_ChIP-Seq_VCAP_Human1.19007552
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.17699293
124* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17408057
125RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16201334
126RNF2_27304074_Chip-Seq_NSC_Mouse1.14863970
127GATA1_19941826_ChIP-Seq_K562_Human1.14487246
128* AR_19668381_ChIP-Seq_PC3_Human1.14403077
129ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13933533
130WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12673391
131VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12570795
132P300_19829295_ChIP-Seq_ESCs_Human1.11236591
133WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10915118
134ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10719338
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10059953
136IGF1R_20145208_ChIP-Seq_DFB_Human1.09412492
137* RACK7_27058665_Chip-Seq_MCF-7_Human1.09348530
138CBX2_27304074_Chip-Seq_ESCs_Mouse1.08744932
139RING1B_27294783_Chip-Seq_NPCs_Mouse1.08627537
140GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07899811
141SMC4_20622854_ChIP-Seq_HELA_Human1.07539797
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07526361
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06773701
144GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06495736
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06466430
146* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05004260
147GATA3_26560356_Chip-Seq_TH2_Human1.04879863
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04760813
149P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04029804
150SMAD3_21741376_ChIP-Seq_EPCs_Human1.02912441
151TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02888749
152TET1_21490601_ChIP-Seq_MESCs_Mouse1.02691945
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02663978
154E2F1_20622854_ChIP-Seq_HELA_Human1.02429172
155SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01029769
156* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00443327
157STAT3_23295773_ChIP-Seq_U87_Human1.00423028
158* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99897629
159CTCF_27219007_Chip-Seq_Bcells_Human0.99244295
160PU_27001747_Chip-Seq_BMDM_Mouse0.98555415
161NCOR1_26117541_ChIP-Seq_K562_Human0.97938741
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97907232
163CTCF_26484167_Chip-Seq_Bcells_Mouse0.97873439
164P300_27268052_Chip-Seq_Bcells_Human0.97734960
165YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97050052
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96826646
167SPI1_20517297_ChIP-Seq_HL60_Human0.96535400
168OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95038753
169SMAD3_21741376_ChIP-Seq_ESCs_Human0.95010899
170* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94995074
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.90937656
172SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90315105
173TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89076967
174TCF4_23295773_ChIP-Seq_U87_Human0.87815725
175AHR_22903824_ChIP-Seq_MCF-7_Human0.87660010
176PRDM14_20953172_ChIP-Seq_ESCs_Human0.87297652
177ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86291844
178CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85411652
179TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85232426
180JUN_21703547_ChIP-Seq_K562_Human0.84676459
181TP53_20018659_ChIP-ChIP_R1E_Mouse0.81845156
182SMAD4_21741376_ChIP-Seq_HESCs_Human0.80134847
183TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79352470
184RUNX2_22187159_ChIP-Seq_PCA_Human0.79280188
185CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79091138
186SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78934262
187PIAS1_25552417_ChIP-Seq_VCAP_Human0.78846720
188TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78598307
189POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78598307
190TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78256484

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.19286711
2MP0003880_abnormal_central_pattern4.81204312
3MP0003436_decreased_susceptibility_to4.38896171
4MP0003724_increased_susceptibility_to4.27997634
5MP0001968_abnormal_touch/_nociception4.13142009
6MP0003635_abnormal_synaptic_transmissio4.01251476
7MP0004270_analgesia3.67099824
8MP0001835_abnormal_antigen_presentation3.65159998
9MP0002736_abnormal_nociception_after3.37280540
10MP0009745_abnormal_behavioral_response3.23096173
11MP0002735_abnormal_chemical_nociception3.22277532
12MP0002063_abnormal_learning/memory/cond3.16573933
13MP0002419_abnormal_innate_immunity3.15331344
14MP0003303_peritoneal_inflammation3.15220365
15MP0005423_abnormal_somatic_nervous3.13532405
16MP0002064_seizures3.06296016
17MP0001800_abnormal_humoral_immune3.02432198
18MP0005671_abnormal_response_to3.02080823
19MP0005025_abnormal_response_to2.95925233
20MP0009046_muscle_twitch2.95794940
21MP0005000_abnormal_immune_tolerance2.88906150
22MP0002734_abnormal_mechanical_nocicepti2.83760405
23MP0000685_abnormal_immune_system2.79711106
24MP0005387_immune_system_phenotype2.75476355
25MP0001790_abnormal_immune_system2.75476355
26MP0002723_abnormal_immune_serum2.68850679
27MP0002572_abnormal_emotion/affect_behav2.67662167
28MP0002420_abnormal_adaptive_immunity2.67201373
29MP0001819_abnormal_immune_cell2.64413607
30MP0002733_abnormal_thermal_nociception2.62999498
31MP0009785_altered_susceptibility_to2.58502496
32MP0002272_abnormal_nervous_system2.57394885
33MP0003763_abnormal_thymus_physiology2.55220952
34MP0002452_abnormal_antigen_presenting2.55172988
35MP0006276_abnormal_autonomic_nervous2.50992143
36MP0001970_abnormal_pain_threshold2.38343299
37MP0006082_CNS_inflammation2.35115634
38MP0001486_abnormal_startle_reflex2.24662141
39MP0001501_abnormal_sleep_pattern2.17913564
40MP0009278_abnormal_bone_marrow2.16929716
41MP0002148_abnormal_hypersensitivity_rea2.12850579
42MP0001440_abnormal_grooming_behavior2.11945176
43MP0004858_abnormal_nervous_system2.11546776
44MP0002184_abnormal_innervation2.09994421
45MP0001533_abnormal_skeleton_physiology2.09702082
46MP0002067_abnormal_sensory_capabilities2.08373244
47MP0002822_catalepsy2.06820772
48MP0002398_abnormal_bone_marrow2.06448153
49MP0005464_abnormal_platelet_physiology2.05763608
50MP0002405_respiratory_system_inflammati2.04575513
51MP0000716_abnormal_immune_system2.03096646
52MP0003329_amyloid_beta_deposits2.00238070
53MP0003300_gastrointestinal_ulcer1.96068494
54MP0004811_abnormal_neuron_physiology1.88418143
55MP0003122_maternal_imprinting1.85636976
56MP0000778_abnormal_nervous_system1.83495954
57MP0004947_skin_inflammation1.80227843
58MP0002557_abnormal_social/conspecific_i1.80188336
59MP0010155_abnormal_intestine_physiology1.78600701
60MP0008569_lethality_at_weaning1.78472458
61MP0002396_abnormal_hematopoietic_system1.76491010
62MP0001984_abnormal_olfaction1.74037751
63MP0008260_abnormal_autophagy1.73124290
64MP0002132_abnormal_respiratory_system1.72467185
65MP0000689_abnormal_spleen_morphology1.71961278
66MP0004381_abnormal_hair_follicle1.70538442
67MP0009333_abnormal_splenocyte_physiolog1.69700953
68MP0003866_abnormal_defecation1.69367620
69MP0001845_abnormal_inflammatory_respons1.69271538
70MP0002722_abnormal_immune_system1.68539056
71MP0002909_abnormal_adrenal_gland1.68503732
72MP0004924_abnormal_behavior1.66351562
73MP0005386_behavior/neurological_phenoty1.66351562
74MP0000955_abnormal_spinal_cord1.66333119
75MP0003879_abnormal_hair_cell1.63250985
76MP0000703_abnormal_thymus_morphology1.63136532
77MP0003191_abnormal_cellular_cholesterol1.61866551
78MP0002429_abnormal_blood_cell1.58625081
79MP0005645_abnormal_hypothalamus_physiol1.54762896
80MP0009780_abnormal_chondrocyte_physiolo1.52500846
81MP0005058_abnormal_lysosome_morphology1.52354777
82MP0000465_gastrointestinal_hemorrhage1.46684728
83MP0003828_pulmonary_edema1.45346834
84MP0002882_abnormal_neuron_morphology1.43415043
85MP0004142_abnormal_muscle_tone1.41399842
86MP0001529_abnormal_vocalization1.37091772
87MP0001905_abnormal_dopamine_level1.36725496
88MP0002066_abnormal_motor_capabilities/c1.36497963
89MP0008469_abnormal_protein_level1.36131839
90MP0001873_stomach_inflammation1.35510118
91MP0005646_abnormal_pituitary_gland1.35002288
92MP0009764_decreased_sensitivity_to1.34449276
93MP0005310_abnormal_salivary_gland1.33627359
94MP0000569_abnormal_digit_pigmentation1.30939692
95MP0003787_abnormal_imprinting1.29345286
96MP0001851_eye_inflammation1.28762118
97MP0002277_abnormal_respiratory_mucosa1.28368384
98MP0001502_abnormal_circadian_rhythm1.26839862
99MP0005397_hematopoietic_system_phenotyp1.25745395
100MP0001545_abnormal_hematopoietic_system1.25745395
101MP0003633_abnormal_nervous_system1.24271089
102MP0002998_abnormal_bone_remodeling1.23975178
103MP0008961_abnormal_basal_metabolism1.22090037
104MP0002933_joint_inflammation1.18529275
105MP0004130_abnormal_muscle_cell1.14983474
106MP0000858_altered_metastatic_potential1.12477867
107MP0001986_abnormal_taste_sensitivity1.11348918
108MP0004883_abnormal_blood_vessel1.09684078
109MP0002166_altered_tumor_susceptibility1.07986157
110MP0002152_abnormal_brain_morphology1.06106625
111MP0005075_abnormal_melanosome_morpholog1.03121562
112MP0003631_nervous_system_phenotype1.02241765
113MP0004885_abnormal_endolymph1.00630812
114MP0001663_abnormal_digestive_system1.00269943
115MP0004510_myositis0.99340530
116MP0005390_skeleton_phenotype0.95586727
117MP0001853_heart_inflammation0.95372133
118MP0002229_neurodegeneration0.94666210
119MP0000604_amyloidosis0.93816387
120MP0002069_abnormal_eating/drinking_beha0.92666174
121MP0000751_myopathy0.91730082
122MP0008872_abnormal_physiological_respon0.90111900
123MP0008874_decreased_physiological_sensi0.90094254
124MP0004808_abnormal_hematopoietic_stem0.89760149
125MP0003183_abnormal_peptide_metabolism0.87930426
126MP0003634_abnormal_glial_cell0.85662844
127MP0001188_hyperpigmentation0.82418136
128MP0004145_abnormal_muscle_electrophysio0.81878356
129MP0005083_abnormal_biliary_tract0.81874743
130MP0002138_abnormal_hepatobiliary_system0.81798061
131MP0003283_abnormal_digestive_organ0.81343875
132MP0000015_abnormal_ear_pigmentation0.80714472
133MP0003172_abnormal_lysosome_physiology0.80154248
134MP0004185_abnormal_adipocyte_glucose0.79462672
135MP0003121_genomic_imprinting0.78897658
136MP0010386_abnormal_urinary_bladder0.77899174
137MP0002752_abnormal_somatic_nervous0.77787525
138MP0004742_abnormal_vestibular_system0.77367327
139MP0005166_decreased_susceptibility_to0.74865202
140MP0002837_dystrophic_cardiac_calcinosis0.74302784
141MP0002751_abnormal_autonomic_nervous0.74133017
142MP0002928_abnormal_bile_duct0.71249581
143MP0000631_abnormal_neuroendocrine_gland0.71118700
144MP0000013_abnormal_adipose_tissue0.70727028
145MP0005451_abnormal_body_composition0.70538367
146MP0001963_abnormal_hearing_physiology0.70464262
147MP0005076_abnormal_cell_differentiation0.69955339
148MP0005164_abnormal_response_to0.69897109
149MP0000490_abnormal_crypts_of0.69607142
150MP0002009_preneoplasia0.67617586
151MP0005394_taste/olfaction_phenotype0.67499112
152MP0005499_abnormal_olfactory_system0.67499112
153MP0003632_abnormal_nervous_system0.67164388
154MP0000920_abnormal_myelination0.66906512
155MP0001664_abnormal_digestion0.66872942
156MP0003075_altered_response_to0.66113688
157MP0009765_abnormal_xenobiotic_induced0.64995231
158MP0009763_increased_sensitivity_to0.64147769
159MP0005535_abnormal_body_temperature0.62763768
160MP0003795_abnormal_bone_structure0.62583285
161MP0004085_abnormal_heartbeat0.62157316
162MP0005377_hearing/vestibular/ear_phenot0.60779842
163MP0003878_abnormal_ear_physiology0.60779842
164MP0005551_abnormal_eye_electrophysiolog0.60748017
165MP0001348_abnormal_lacrimal_gland0.59547603
166MP0003045_fibrosis0.59278835
167MP0003861_abnormal_nervous_system0.58062517
168MP0002006_tumorigenesis0.56740420
169MP0003638_abnormal_response/metabolism_0.55529133
170MP0000249_abnormal_blood_vessel0.55249646
171MP0001299_abnormal_eye_distance/0.55176220
172MP0002638_abnormal_pupillary_reflex0.54361056
173MP0005381_digestive/alimentary_phenotyp0.52842714
174MP0010769_abnormal_survival0.52715741
175MP0003448_altered_tumor_morphology0.52463934
176MP0001943_abnormal_respiration0.52299091
177MP0002693_abnormal_pancreas_physiology0.52283742
178MP0003690_abnormal_glial_cell0.51897015
179MP0001765_abnormal_ion_homeostasis0.51636590
180MP0002082_postnatal_lethality0.51429037
181MP0010770_preweaning_lethality0.51429037
182MP0001177_atelectasis0.51419266
183MP0002090_abnormal_vision0.51377413
184MP0002653_abnormal_ependyma_morphology0.50233083
185MP0003137_abnormal_impulse_conducting0.50176522
186MP0003956_abnormal_body_size0.50012035
187MP0010768_mortality/aging0.49672042
188MP0000470_abnormal_stomach_morphology0.49081945
189MP0006072_abnormal_retinal_apoptosis0.48469923
190MP0000681_abnormal_thyroid_gland0.48347208
191MP0001485_abnormal_pinna_reflex0.46221549

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.54762165
2Myokymia (HP:0002411)7.01165222
3Eczematoid dermatitis (HP:0000976)6.30434185
4Visual hallucinations (HP:0002367)6.16428899
5Focal seizures (HP:0007359)6.07291519
6Recurrent abscess formation (HP:0002722)5.92326093
7Recurrent bacterial skin infections (HP:0005406)5.80418263
8Myositis (HP:0100614)5.40430758
9Elevated erythrocyte sedimentation rate (HP:0003565)5.12206182
10Abnormality of macrophages (HP:0004311)4.85924033
11Stomatitis (HP:0010280)4.67347072
12Recurrent fungal infections (HP:0002841)4.50818127
13Orchitis (HP:0100796)4.50598247
14Recurrent gram-negative bacterial infections (HP:0005420)4.44566965
15Absence seizures (HP:0002121)4.39515565
16Epileptic encephalopathy (HP:0200134)4.36933526
17Febrile seizures (HP:0002373)4.31211130
18Abnormal delayed hypersensitivity skin test (HP:0002963)4.27826245
19Atonic seizures (HP:0010819)4.25694601
20Progressive cerebellar ataxia (HP:0002073)4.22432387
21Retrobulbar optic neuritis (HP:0100654)4.20769364
22Optic neuritis (HP:0100653)4.20769364
23Supranuclear gaze palsy (HP:0000605)4.16581305
24Obstructive lung disease (HP:0006536)4.06744766
25Chronic obstructive pulmonary disease (HP:0006510)4.06744766
26Mediastinal lymphadenopathy (HP:0100721)4.06478828
27Recurrent skin infections (HP:0001581)3.99180481
28Meningitis (HP:0001287)3.98920043
29Dialeptic seizures (HP:0011146)3.91874722
30Ankle clonus (HP:0011448)3.87952815
31Recurrent cutaneous fungal infections (HP:0011370)3.87788015
32Chronic mucocutaneous candidiasis (HP:0002728)3.87788015
33Increased IgE level (HP:0003212)3.86581574
34Gastrointestinal infarctions (HP:0005244)3.84983534
35Action tremor (HP:0002345)3.76124820
36Panhypogammaglobulinemia (HP:0003139)3.69328580
37Generalized tonic-clonic seizures (HP:0002069)3.62181117
38Encephalitis (HP:0002383)3.61127740
39Pustule (HP:0200039)3.38942896
40Spontaneous hematomas (HP:0007420)3.36727901
41Gingivitis (HP:0000230)3.33061735
42Prolonged bleeding time (HP:0003010)3.31370043
43Hypochromic anemia (HP:0001931)3.23006580
44Mutism (HP:0002300)3.21361832
45Abnormal eating behavior (HP:0100738)3.21227015
46Vasculitis (HP:0002633)3.20430029
47Cellulitis (HP:0100658)3.11017967
48Depression (HP:0000716)3.09237414
49Impaired vibration sensation in the lower limbs (HP:0002166)3.08733907
50Hypochromic microcytic anemia (HP:0004840)3.07809540
51Truncal ataxia (HP:0002078)3.04836149
52Progressive inability to walk (HP:0002505)3.02336370
53Poor eye contact (HP:0000817)3.01468985
54Broad-based gait (HP:0002136)3.01437190
55Urticaria (HP:0001025)3.00920784
56Recurrent viral infections (HP:0004429)2.99383723
57Urinary bladder sphincter dysfunction (HP:0002839)2.95729090
58Keratoconjunctivitis sicca (HP:0001097)2.94368466
59Inflammation of the large intestine (HP:0002037)2.93366287
60Spastic gait (HP:0002064)2.93201836
61Urinary urgency (HP:0000012)2.92550892
62Gastrointestinal inflammation (HP:0004386)2.92256883
63Chest pain (HP:0100749)2.91966331
64Papilledema (HP:0001085)2.91901819
65Polyphagia (HP:0002591)2.91266276
66Leukocytosis (HP:0001974)2.90520790
67Hemoptysis (HP:0002105)2.88164992
68Failure to thrive in infancy (HP:0001531)2.85100231
69Abnormality of the lower motor neuron (HP:0002366)2.84606346
70Granulocytopenia (HP:0001913)2.79962211
71Postural instability (HP:0002172)2.79110722
72Amblyopia (HP:0000646)2.78000993
73Keratoconjunctivitis (HP:0001096)2.75424295
74Dysmetria (HP:0001310)2.74959392
75Pulmonary infiltrates (HP:0002113)2.74860754
76Impaired social interactions (HP:0000735)2.74353774
77Abnormal social behavior (HP:0012433)2.74353774
78Gaze-evoked nystagmus (HP:0000640)2.73874659
79T lymphocytopenia (HP:0005403)2.72584243
80Anxiety (HP:0000739)2.70816044
81Colitis (HP:0002583)2.66866742
82Agammaglobulinemia (HP:0004432)2.66287597
83Increased cerebral lipofuscin (HP:0011813)2.66195066
84Episodic fever (HP:0001954)2.65196551
85Abnormality of T cell number (HP:0011839)2.61954888
86Scanning speech (HP:0002168)2.61235554
87Epistaxis (HP:0000421)2.61072225
88Abnormality of T cells (HP:0002843)2.60545203
89Dysdiadochokinesis (HP:0002075)2.59662236
90Limb dystonia (HP:0002451)2.56208093
91Amyloidosis (HP:0011034)2.52747313
92Pheochromocytoma (HP:0002666)2.51688221
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.49770306
94Hemiplegia (HP:0002301)2.49056096
95Termporal pattern (HP:0011008)2.47081829
96Insidious onset (HP:0003587)2.47081829
97Amyotrophic lateral sclerosis (HP:0007354)2.46306961
98Torticollis (HP:0000473)2.45698718
99Abnormality of binocular vision (HP:0011514)2.44143915
100Diplopia (HP:0000651)2.44143915
101Pulmonary embolism (HP:0002204)2.43198166
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42963854
103Hemiparesis (HP:0001269)2.42134410
104Genetic anticipation (HP:0003743)2.41759039
105Abnormality of the corticospinal tract (HP:0002492)2.41589664
106Impaired smooth pursuit (HP:0007772)2.40280256
107Bradykinesia (HP:0002067)2.39633569
108Drooling (HP:0002307)2.38799339
109Excessive salivation (HP:0003781)2.38799339
110Sepsis (HP:0100806)2.36350420
111Insomnia (HP:0100785)2.34633357
112Psychosis (HP:0000709)2.34183821
113Hypoventilation (HP:0002791)2.32028127
114Cerebral inclusion bodies (HP:0100314)2.31411369
115Arterial thrombosis (HP:0004420)2.30161214
116Neurofibrillary tangles (HP:0002185)2.30009085
117Hyperventilation (HP:0002883)2.28919927
118Dysostosis multiplex (HP:0000943)2.27992057
119Gingival bleeding (HP:0000225)2.27030750
120Focal dystonia (HP:0004373)2.26500804
121Abnormality of T cell physiology (HP:0011840)2.26163002
122Lymphopenia (HP:0001888)2.25860978
123Anorexia (HP:0002039)2.25606995
124Osteomyelitis (HP:0002754)2.24261825
125Pointed chin (HP:0000307)2.23939031
126Stereotypic behavior (HP:0000733)2.23914143
127Lower limb muscle weakness (HP:0007340)2.23450246
128Petechiae (HP:0000967)2.22839798
129Aplasia/Hypoplasia of the brainstem (HP:0007362)2.22040782
130Hypoplasia of the brainstem (HP:0002365)2.22040782
131Hypergammaglobulinemia (HP:0010702)2.18276516
132Agitation (HP:0000713)2.18036930
133Inability to walk (HP:0002540)2.17457123
134Eosinophilia (HP:0001880)2.17111832
135Epileptiform EEG discharges (HP:0011182)2.16219934
136Microcytic anemia (HP:0001935)2.15900887
137Neuroendocrine neoplasm (HP:0100634)2.15659920
138Abnormality of ocular smooth pursuit (HP:0000617)2.15636108
139Fetal akinesia sequence (HP:0001989)2.15411863
140Ventricular fibrillation (HP:0001663)2.14640051
141Increased IgM level (HP:0003496)2.14398904
142Impaired pain sensation (HP:0007328)2.13930719
143Abnormality of pain sensation (HP:0010832)2.13930719
144Intention tremor (HP:0002080)2.13097317
145EEG with generalized epileptiform discharges (HP:0011198)2.12221290
146Specific learning disability (HP:0001328)2.11982645
147Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.11933849
148Rapidly progressive (HP:0003678)2.10654680
149Neuronal loss in central nervous system (HP:0002529)2.10213663
150Abnormality of the pleura (HP:0002103)2.08876861
151Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08822797
152Abnormality of cells of the lymphoid lineage (HP:0012140)2.06720007
153Craniofacial dystonia (HP:0012179)2.06590600
154Papilloma (HP:0012740)2.06258807
155Verrucae (HP:0200043)2.06258807
156Peritonitis (HP:0002586)2.04812774
157Chronic otitis media (HP:0000389)2.04578452
158Sleep apnea (HP:0010535)2.03270931
159Hypsarrhythmia (HP:0002521)2.03111107
160Abnormality of glycolipid metabolism (HP:0010969)2.01530306
161Abnormality of liposaccharide metabolism (HP:0010968)2.01530306
162Abnormality of glycosphingolipid metabolism (HP:0004343)2.01530306
163Ulnar claw (HP:0001178)1.99462006
164Poor suck (HP:0002033)1.99423176
165Severe combined immunodeficiency (HP:0004430)1.97364069
166Clonus (HP:0002169)1.96423530
167Abnormal hair whorl (HP:0010721)1.96320768
168Generalized hypotonia (HP:0001290)1.96309793
169Retinal dysplasia (HP:0007973)1.95731921
170Abnormality of eosinophils (HP:0001879)1.94360095
171Skin ulcer (HP:0200042)1.92687590
172Increased serum ferritin (HP:0003281)1.92264089
173Purpura (HP:0000979)1.91948995
174Megalencephaly (HP:0001355)1.91334248
175Status epilepticus (HP:0002133)1.90938734
176Autoimmune thrombocytopenia (HP:0001973)1.90636863
177Polygenic inheritance (HP:0010982)1.89218056
178Esotropia (HP:0000565)1.87748735
179Generalized myoclonic seizures (HP:0002123)1.87511088
180Rigidity (HP:0002063)1.87412799
181Akinesia (HP:0002304)1.87235143
182Absent speech (HP:0001344)1.86038665
183Gait ataxia (HP:0002066)1.85554902
184Vertigo (HP:0002321)1.85506881
185Loss of speech (HP:0002371)1.84907587
186Gait imbalance (HP:0002141)1.84650193
187Abnormality of the endocardium (HP:0004306)1.84049422
188Restrictive lung disease (HP:0002091)1.82779711
189Apathy (HP:0000741)1.82582623
190Iris hypopigmentation (HP:0007730)1.82229087
191Abnormality of polysaccharide metabolism (HP:0011012)1.81466935
192Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81466935
193Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81466935
194Obstructive sleep apnea (HP:0002870)1.80454057
195Slow saccadic eye movements (HP:0000514)1.80372185
196Gangrene (HP:0100758)1.80314215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.55961255
2NTRK34.28991255
3MAP4K13.96819682
4MARK13.35786089
5MINK13.16873855
6MAP3K123.12293609
7EPHA42.85865222
8MAP2K32.80050844
9MAP3K42.77612906
10ERN12.63269609
11BLK2.62623165
12NTRK22.54914057
13GRK62.50974344
14IRAK42.40379356
15KSR22.32647153
16MAP2K72.32109991
17PAK62.32061121
18TYK22.29409102
19RIPK42.25209965
20ZAP702.13042639
21DAPK22.11709813
22CSK2.10147751
23MAP2K42.01072415
24BTK1.91906531
25TRIB31.89834872
26NTRK11.89028921
27TXK1.86325061
28SIK21.85026280
29KSR11.81445803
30MAP3K111.78830916
31TNIK1.73300261
32TAOK31.70912021
33ARAF1.65760672
34CAMKK11.63574562
35MAPK131.60733749
36HCK1.57961919
37PRKD21.56417554
38KIT1.55447779
39CDK51.53827015
40GRK51.53256549
41DAPK11.52718565
42CDK191.52016384
43UHMK11.49381817
44TBK11.47945389
45CAMKK21.43739171
46IKBKE1.42655219
47EPHB11.41254746
48JAK31.40397196
49FES1.38238979
50MAP3K141.35751670
51CASK1.33515808
52MAP3K31.31845922
53PNCK1.30896043
54CSF1R1.29886310
55ITK1.29786199
56LYN1.25096053
57PRKD31.24863936
58LCK1.24155039
59MAP3K21.22833119
60SIK11.15760303
61TYRO31.15082410
62PRKCG1.13517824
63MAP3K131.13226374
64PHKG21.13066226
65PHKG11.13066226
66MAP3K61.12412855
67TEC1.07377151
68SIK31.07112614
69PLK21.04816364
70JAK11.04235779
71CAMK11.02283809
72JAK21.00141310
73TAOK11.00087538
74CDK180.99908208
75LMTK20.99414535
76RET0.99111965
77IKBKB0.98743235
78CDK140.97399968
79PRPF4B0.95436549
80LATS20.95134609
81CDK150.94757880
82MARK30.92693781
83STK380.90583703
84PTK60.89283144
85CDK11A0.86223447
86PAK30.85387342
87TAOK20.84015242
88HIPK20.82459142
89MARK20.80631482
90TESK20.79540166
91CSNK1G20.79039024
92CAMK2A0.77978879
93RAF10.77138044
94IRAK20.74592949
95SGK4940.74178813
96SGK2230.74178813
97RPS6KC10.72714049
98RPS6KL10.72714049
99PKN20.72417737
100MAP2K60.71814348
101TNK20.71763433
102SMG10.71488368
103STK110.71317996
104MAPK70.71209595
105PRKCH0.70983711
106RPS6KA60.69392953
107IRAK10.68783030
108PRKCQ0.68155913
109MAP3K10.67199099
110MATK0.66503545
111MUSK0.65567762
112CAMK1G0.64100697
113DYRK1A0.63600679
114LIMK10.63518422
115MAP2K20.62189202
116RPS6KA20.61421900
117FER0.61189707
118PTK2B0.58906765
119ALK0.55857328
120SCYL20.55335032
121YES10.54032626
122DYRK1B0.53750995
123CDC42BPA0.52151330
124CAMK2B0.49785631
125FYN0.49446457
126LRRK20.48872114
127PRKCZ0.46384045
128SGK20.46050697
129NEK10.45411821
130SGK10.45249449
131MAP3K70.44664965
132FGR0.43919021
133MAPK100.43861253
134PDK10.43393280
135MAP2K10.43118475
136SYK0.42124662
137STK100.41203747
138CAMK40.39216675
139CSNK1G30.39035897
140BRAF0.37866586
141RPS6KA30.37795018
142PIM10.37721985
143PRKCE0.37063640
144MAPK40.36203789
145SGK30.35847319
146BMPR20.35784645
147BRSK10.35593892
148TGFBR20.35462480
149FGFR20.35431538
150PDPK10.34845051
151RIPK10.33889530
152PINK10.33400073
153ROCK20.33348735
154DAPK30.33184418
155PRKD10.33023241
156FGFR40.32649097
157CDK40.32494200
158FGFR30.31202112
159MAPKAPK20.30776887
160MAPK120.30736403
161MAPK150.30525319
162MAPKAPK50.29895780
163ADRBK10.29387351
164RPS6KA10.27779297
165CHUK0.27651173
166MAPK30.26568443

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.57665608
2Nicotine addiction_Homo sapiens_hsa050333.57080458
3Osteoclast differentiation_Homo sapiens_hsa043802.73412031
4Leishmaniasis_Homo sapiens_hsa051402.61655941
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60812065
6Circadian entrainment_Homo sapiens_hsa047132.58743869
7Olfactory transduction_Homo sapiens_hsa047402.57910233
8GABAergic synapse_Homo sapiens_hsa047272.55175793
9Long-term potentiation_Homo sapiens_hsa047202.54965859
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47186322
11Primary immunodeficiency_Homo sapiens_hsa053402.45883416
12Glutamatergic synapse_Homo sapiens_hsa047242.44464716
13Morphine addiction_Homo sapiens_hsa050322.37727386
14Staphylococcus aureus infection_Homo sapiens_hsa051502.25403156
15Amphetamine addiction_Homo sapiens_hsa050312.18590252
16Dopaminergic synapse_Homo sapiens_hsa047282.16422067
17Graft-versus-host disease_Homo sapiens_hsa053322.16300327
18Allograft rejection_Homo sapiens_hsa053302.09356528
19Salivary secretion_Homo sapiens_hsa049702.00634846
20Insulin secretion_Homo sapiens_hsa049111.98695089
21Autoimmune thyroid disease_Homo sapiens_hsa053201.96277469
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90604589
23Other glycan degradation_Homo sapiens_hsa005111.87981720
24Cholinergic synapse_Homo sapiens_hsa047251.87745357
25Tuberculosis_Homo sapiens_hsa051521.87126757
26Taste transduction_Homo sapiens_hsa047421.82552601
27T cell receptor signaling pathway_Homo sapiens_hsa046601.81848377
28Acute myeloid leukemia_Homo sapiens_hsa052211.80009694
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77177501
30Gastric acid secretion_Homo sapiens_hsa049711.76892376
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75004730
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73492335
33Long-term depression_Homo sapiens_hsa047301.69343829
34Collecting duct acid secretion_Homo sapiens_hsa049661.68171119
35Serotonergic synapse_Homo sapiens_hsa047261.62327376
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61309264
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60858524
38Hematopoietic cell lineage_Homo sapiens_hsa046401.58876002
39GnRH signaling pathway_Homo sapiens_hsa049121.58132925
40Oxytocin signaling pathway_Homo sapiens_hsa049211.56253955
41Cocaine addiction_Homo sapiens_hsa050301.53886891
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.51666946
43Malaria_Homo sapiens_hsa051441.50728110
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.49286531
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.48971410
46Renin secretion_Homo sapiens_hsa049241.48147515
47Calcium signaling pathway_Homo sapiens_hsa040201.47238446
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43999683
49Measles_Homo sapiens_hsa051621.42739879
50Antigen processing and presentation_Homo sapiens_hsa046121.42486794
51Gap junction_Homo sapiens_hsa045401.39326780
52Toxoplasmosis_Homo sapiens_hsa051451.32885266
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30530604
54Asthma_Homo sapiens_hsa053101.29618027
55Influenza A_Homo sapiens_hsa051641.27186235
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25191262
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24506792
58TNF signaling pathway_Homo sapiens_hsa046681.20127574
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.19173521
60Estrogen signaling pathway_Homo sapiens_hsa049151.18358769
61Axon guidance_Homo sapiens_hsa043601.17400850
62Platelet activation_Homo sapiens_hsa046111.16204149
63Glioma_Homo sapiens_hsa052141.15797064
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.15651559
65Viral myocarditis_Homo sapiens_hsa054161.14105171
66Herpes simplex infection_Homo sapiens_hsa051681.13886945
67Type II diabetes mellitus_Homo sapiens_hsa049301.13777430
68Vibrio cholerae infection_Homo sapiens_hsa051101.12371008
69cAMP signaling pathway_Homo sapiens_hsa040241.11706223
70ErbB signaling pathway_Homo sapiens_hsa040121.08042595
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07588946
72Melanogenesis_Homo sapiens_hsa049161.06555692
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.06114997
74Phagosome_Homo sapiens_hsa041451.06013160
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00663327
76Cardiac muscle contraction_Homo sapiens_hsa042600.99965382
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98650980
78Oocyte meiosis_Homo sapiens_hsa041140.98584185
79Hepatitis C_Homo sapiens_hsa051600.98457650
80Hepatitis B_Homo sapiens_hsa051610.98435300
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.97660239
82Legionellosis_Homo sapiens_hsa051340.97356843
83Notch signaling pathway_Homo sapiens_hsa043300.96837319
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.96552896
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95549447
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92399796
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.89528316
88Pertussis_Homo sapiens_hsa051330.88602096
89Chronic myeloid leukemia_Homo sapiens_hsa052200.88582312
90Lysosome_Homo sapiens_hsa041420.87643482
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87549218
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85582455
93VEGF signaling pathway_Homo sapiens_hsa043700.84802010
94Shigellosis_Homo sapiens_hsa051310.78946933
95Dorso-ventral axis formation_Homo sapiens_hsa043200.78837708
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.78383073
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77870874
98Pancreatic cancer_Homo sapiens_hsa052120.77746930
99Choline metabolism in cancer_Homo sapiens_hsa052310.77554770
100Pancreatic secretion_Homo sapiens_hsa049720.75600551
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.74766528
102MAPK signaling pathway_Homo sapiens_hsa040100.74401941
103Apoptosis_Homo sapiens_hsa042100.73026047
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71763944
105Thyroid hormone synthesis_Homo sapiens_hsa049180.70087753
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70032485
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70032245
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.70014292
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66691780
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66022424
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.63588749
112Regulation of autophagy_Homo sapiens_hsa041400.62918464
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62211613
114Endocytosis_Homo sapiens_hsa041440.60671202
115Alcoholism_Homo sapiens_hsa050340.60666226
116Inositol phosphate metabolism_Homo sapiens_hsa005620.60332482
117Alzheimers disease_Homo sapiens_hsa050100.59616168
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59212682
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59088336
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58848774
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58459269
122Ras signaling pathway_Homo sapiens_hsa040140.57175634
123Endometrial cancer_Homo sapiens_hsa052130.56858900
124Epstein-Barr virus infection_Homo sapiens_hsa051690.56606598
125FoxO signaling pathway_Homo sapiens_hsa040680.56116178
126Rap1 signaling pathway_Homo sapiens_hsa040150.55276303
127Insulin resistance_Homo sapiens_hsa049310.54415929
128Non-small cell lung cancer_Homo sapiens_hsa052230.54339978
129HTLV-I infection_Homo sapiens_hsa051660.53190369
130Viral carcinogenesis_Homo sapiens_hsa052030.52760802
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52359091
132Phototransduction_Homo sapiens_hsa047440.51194193
133Dilated cardiomyopathy_Homo sapiens_hsa054140.50640999
134mTOR signaling pathway_Homo sapiens_hsa041500.50350318
135Insulin signaling pathway_Homo sapiens_hsa049100.49375858
136Glucagon signaling pathway_Homo sapiens_hsa049220.48127387
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46912511
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46591422
139Oxidative phosphorylation_Homo sapiens_hsa001900.46502160
140Prion diseases_Homo sapiens_hsa050200.46485025
141Colorectal cancer_Homo sapiens_hsa052100.46466147
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45540495
143Chemokine signaling pathway_Homo sapiens_hsa040620.42637907
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42022747
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41938093
146Renal cell carcinoma_Homo sapiens_hsa052110.39477778
147Prolactin signaling pathway_Homo sapiens_hsa049170.38958668
148Wnt signaling pathway_Homo sapiens_hsa043100.38830949
149Salmonella infection_Homo sapiens_hsa051320.37952170
150Parkinsons disease_Homo sapiens_hsa050120.37709588
151Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36761176
152Type I diabetes mellitus_Homo sapiens_hsa049400.36539910
153B cell receptor signaling pathway_Homo sapiens_hsa046620.35620956
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35581859
155African trypanosomiasis_Homo sapiens_hsa051430.31308290
156Rheumatoid arthritis_Homo sapiens_hsa053230.30349849
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29938540

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