ANGPTL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosylated, secreted protein containing a C-terminal fibrinogen domain. The encoded protein is induced by peroxisome proliferation activators and functions as a serum hormone that regulates glucose homeostasis, lipid metabolism, and insulin sensitivity. This protein can also act as an apoptosis survival factor for vascular endothelial cells and can prevent metastasis by inhibiting vascular growth and tumor cell invasion. The C-terminal domain may be proteolytically-cleaved from the full-length secreted protein. Decreased expression of this gene has been associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)8.21271186
2hemidesmosome assembly (GO:0031581)6.22782472
3cellular response to cadmium ion (GO:0071276)6.02118374
4alpha-linolenic acid metabolic process (GO:0036109)5.58519382
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.48038547
6L-phenylalanine catabolic process (GO:0006559)5.48038547
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.42945365
8L-phenylalanine metabolic process (GO:0006558)5.42945365
9regulation of sequestering of triglyceride (GO:0010889)5.41701468
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.35397275
11low-density lipoprotein particle clearance (GO:0034383)5.22396951
12regulation of triglyceride catabolic process (GO:0010896)5.10643770
13complement activation, alternative pathway (GO:0006957)4.91344365
14positive regulation of fatty acid beta-oxidation (GO:0032000)4.89198518
15sulfur amino acid catabolic process (GO:0000098)4.83459209
16aromatic amino acid family catabolic process (GO:0009074)4.75051705
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.73825236
18valine metabolic process (GO:0006573)4.72111510
19fatty acid beta-oxidation (GO:0006635)4.69680172
20plasma lipoprotein particle clearance (GO:0034381)4.64002316
21triglyceride catabolic process (GO:0019433)4.62301475
22positive regulation of fatty acid oxidation (GO:0046321)4.51864572
23cysteine metabolic process (GO:0006534)4.48926085
24fatty acid oxidation (GO:0019395)4.41471182
25neutral lipid catabolic process (GO:0046461)4.41257932
26acylglycerol catabolic process (GO:0046464)4.41257932
27fatty acid transmembrane transport (GO:1902001)4.39962984
28regulation of protein activation cascade (GO:2000257)4.39873502
29glyoxylate metabolic process (GO:0046487)4.38245292
30lysine metabolic process (GO:0006553)4.37681353
31lysine catabolic process (GO:0006554)4.37681353
32negative regulation of fibrinolysis (GO:0051918)4.35323261
33lipid oxidation (GO:0034440)4.33854788
34urea cycle (GO:0000050)4.33257870
35urea metabolic process (GO:0019627)4.33257870
36bile acid biosynthetic process (GO:0006699)4.32969681
37biotin metabolic process (GO:0006768)4.32406475
38positive regulation of lipid catabolic process (GO:0050996)4.30148444
39protein carboxylation (GO:0018214)4.26129359
40peptidyl-glutamic acid carboxylation (GO:0017187)4.26129359
41fatty acid catabolic process (GO:0009062)4.25715066
42amino-acid betaine metabolic process (GO:0006577)4.21623763
43regulation of complement activation (GO:0030449)4.21338303
44* acylglycerol homeostasis (GO:0055090)4.21080391
45* triglyceride homeostasis (GO:0070328)4.21080391
46peptidyl-proline hydroxylation (GO:0019511)4.16459047
47acetyl-CoA metabolic process (GO:0006084)4.15955005
48indole-containing compound catabolic process (GO:0042436)4.12171704
49indolalkylamine catabolic process (GO:0046218)4.12171704
50tryptophan catabolic process (GO:0006569)4.12171704
51kynurenine metabolic process (GO:0070189)4.11355817
52regulation of fibrinolysis (GO:0051917)4.09490888
53high-density lipoprotein particle remodeling (GO:0034375)4.09064479
54nitrogen cycle metabolic process (GO:0071941)4.00734223
55regulation of fatty acid beta-oxidation (GO:0031998)3.98886868
56serine family amino acid catabolic process (GO:0009071)3.98580920
57regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.96506689
58tryptophan metabolic process (GO:0006568)3.89702652
59homocysteine metabolic process (GO:0050667)3.88918964
60bile acid metabolic process (GO:0008206)3.86714158
61monocarboxylic acid catabolic process (GO:0072329)3.86182864
62protein hydroxylation (GO:0018126)3.85808531
63reverse cholesterol transport (GO:0043691)3.84029474
64regulation of cholesterol storage (GO:0010885)3.83170748
65regulation of apoptotic process involved in morphogenesis (GO:1902337)3.82799716
66carnitine shuttle (GO:0006853)3.82647329
67cell adhesion mediated by integrin (GO:0033627)3.82424362
68regulation of fatty acid oxidation (GO:0046320)3.81318604
69protein-lipid complex remodeling (GO:0034368)3.80811865
70macromolecular complex remodeling (GO:0034367)3.80811865
71plasma lipoprotein particle remodeling (GO:0034369)3.80811865
72regulation of metalloenzyme activity (GO:0048552)3.80553915
73branched-chain amino acid catabolic process (GO:0009083)3.73021943
74epoxygenase P450 pathway (GO:0019373)3.69814607
75desmosome organization (GO:0002934)3.69695403
76carnitine metabolic process (GO:0009437)3.67120229
77positive regulation of triglyceride metabolic process (GO:0090208)3.66902123
782-oxoglutarate metabolic process (GO:0006103)3.66131559
79brown fat cell differentiation (GO:0050873)3.65660850
80endodermal cell differentiation (GO:0035987)3.65561916
81cell-substrate junction assembly (GO:0007044)3.63595498
82branched-chain amino acid metabolic process (GO:0009081)3.61798980
83short-chain fatty acid metabolic process (GO:0046459)3.61189829
84regulation of cholesterol esterification (GO:0010872)3.60998292
85alpha-amino acid catabolic process (GO:1901606)3.60648798
86lung vasculature development (GO:0060426)3.60049327
87ethanol oxidation (GO:0006069)3.59755078
88positive regulation of fatty acid metabolic process (GO:0045923)3.57007499
89skin morphogenesis (GO:0043589)3.55561512
90regulation of triglyceride metabolic process (GO:0090207)3.55344126
91tyrosine metabolic process (GO:0006570)3.52533818
92regulation of membrane protein ectodomain proteolysis (GO:0051043)3.48681904
93organic acid catabolic process (GO:0016054)3.46791013
94carboxylic acid catabolic process (GO:0046395)3.46791013
95regulation of gonadotropin secretion (GO:0032276)3.46722586
96phospholipid homeostasis (GO:0055091)3.45957612
97branching involved in labyrinthine layer morphogenesis (GO:0060670)3.45760112
98aromatic amino acid family metabolic process (GO:0009072)3.45345775
99cellular amino acid catabolic process (GO:0009063)3.44711831
100triglyceride metabolic process (GO:0006641)3.44264039
101positive regulation of triglyceride lipase activity (GO:0061365)3.43742109
102positive regulation of lipoprotein lipase activity (GO:0051006)3.43742109
103negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.42329047
104phospholipid efflux (GO:0033700)3.42026767
105positive regulation of monocyte chemotaxis (GO:0090026)3.41170090
106positive regulation of lipid storage (GO:0010884)3.40231705
1074-hydroxyproline metabolic process (GO:0019471)3.35574092
108regulation of cholesterol metabolic process (GO:0090181)3.31516780
109coenzyme catabolic process (GO:0009109)3.29584319
110regulation of cholesterol homeostasis (GO:2000188)3.28470067
111cholesterol homeostasis (GO:0042632)3.28416334
112acyl-CoA biosynthetic process (GO:0071616)3.27418238
113thioester biosynthetic process (GO:0035384)3.27418238
114cellular ketone body metabolic process (GO:0046950)3.27321915
115fatty-acyl-CoA biosynthetic process (GO:0046949)3.26963792
116negative regulation of fatty acid biosynthetic process (GO:0045717)3.25468812
117sterol homeostasis (GO:0055092)3.24832616
118acylglycerol metabolic process (GO:0006639)3.24092097
119fibrinolysis (GO:0042730)3.23119835
120cytolysis (GO:0019835)3.22698882
121regulation of integrin-mediated signaling pathway (GO:2001044)3.19882138
122positive regulation of calcium ion import (GO:0090280)3.10957621
123vascular endothelial growth factor signaling pathway (GO:0038084)3.10930404
124UDP-N-acetylglucosamine metabolic process (GO:0006047)3.10624450
125nucleotide-sugar biosynthetic process (GO:0009226)3.09837008
126regulation of vitamin D biosynthetic process (GO:0060556)3.08941827
127lipid storage (GO:0019915)3.06479553
128positive regulation of protein kinase C signaling (GO:0090037)3.06293182
129vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.03161281
130response to zinc ion (GO:0010043)2.94153127
131cell migration involved in heart development (GO:0060973)2.92805772
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92525638
133endocrine hormone secretion (GO:0060986)2.92434794
134regulation of plasminogen activation (GO:0010755)2.92020562
135chondrocyte proliferation (GO:0035988)2.89132593
136positive regulation of p38MAPK cascade (GO:1900745)2.88988274
137positive regulation of blood vessel endothelial cell migration (GO:0043536)2.88258718
138negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.86518530
139regulation of cytokine secretion involved in immune response (GO:0002739)2.82080756
140regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81013220
141endothelium development (GO:0003158)2.80346624
142positive regulation of fat cell differentiation (GO:0045600)2.77295352
143cellular copper ion homeostasis (GO:0006878)2.75485304
144regulation of vitamin metabolic process (GO:0030656)2.75341454
145regulation of axon extension involved in axon guidance (GO:0048841)2.74762915
146positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.74487458
147negative regulation of protein autophosphorylation (GO:0031953)2.71604207
148type B pancreatic cell proliferation (GO:0044342)2.69727340
149retina vasculature morphogenesis in camera-type eye (GO:0061299)2.69253586
150negative regulation of smooth muscle cell migration (GO:0014912)2.66835586
151cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.66025313
152positive regulation of positive chemotaxis (GO:0050927)2.63182044
153response to cadmium ion (GO:0046686)2.61051677
154lymphangiogenesis (GO:0001946)2.60825423
155wound healing, spreading of epidermal cells (GO:0035313)2.59234318
156regulation of positive chemotaxis (GO:0050926)2.58230266
157decidualization (GO:0046697)2.55080285
158regulation of monocyte chemotaxis (GO:0090025)2.55002964
159positive regulation of metanephros development (GO:0072216)2.53951058
160keratinocyte proliferation (GO:0043616)2.50225857
161positive regulation of endothelial cell apoptotic process (GO:2000353)2.50093701
162maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50043742
163endothelial cell chemotaxis (GO:0035767)2.48789318
164regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.47654635
165protein localization to endosome (GO:0036010)2.47375952
166positive regulation of extracellular matrix organization (GO:1903055)2.46769785
167L-serine transport (GO:0015825)2.46196658
168serine transport (GO:0032329)2.45631492
169virion attachment to host cell (GO:0019062)2.41269651
170adhesion of symbiont to host cell (GO:0044650)2.41269651
171mesenchymal-epithelial cell signaling (GO:0060638)2.40528474
172negative regulation of anoikis (GO:2000811)2.40430443
173barbed-end actin filament capping (GO:0051016)2.39774463
174COPII vesicle coating (GO:0048208)2.39305129
175regulation of lipid storage (GO:0010883)2.38328195
176protein heterotrimerization (GO:0070208)2.34374143
177positive regulation of chemokine biosynthetic process (GO:0045080)2.33545751
178glucocorticoid biosynthetic process (GO:0006704)2.31579420
179regulation of p38MAPK cascade (GO:1900744)2.30329926
180adhesion of symbiont to host (GO:0044406)2.30032908
181regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.29553564
182cAMP biosynthetic process (GO:0006171)2.29140324
183negative regulation of viral entry into host cell (GO:0046597)2.28630415
184positive regulation of astrocyte differentiation (GO:0048711)2.28512295
185extracellular matrix assembly (GO:0085029)2.27501697
186regulation of protein kinase C signaling (GO:0090036)2.27191890
187regulation of smooth muscle cell migration (GO:0014910)2.25129377
188negative regulation of nitric oxide biosynthetic process (GO:0045019)2.24349047
189regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.24201862
190progesterone metabolic process (GO:0042448)2.23991189
191regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.23757796
192negative regulation of lipid storage (GO:0010888)2.23253870
193hyaluronan catabolic process (GO:0030214)2.22610287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.72313254
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.45700087
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.83702557
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94178291
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.36425474
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.75055101
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.49064911
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.29781450
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91759144
10* CLOCK_20551151_ChIP-Seq_293T_Human3.52616053
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43306590
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.91179634
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.87747110
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.25316103
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23989828
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88587812
17* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88366472
18* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88366472
19* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76606864
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.75508576
21JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73576466
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.72386703
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.71443959
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.67182755
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.62615719
26GATA1_22025678_ChIP-Seq_K562_Human1.62573164
27UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54145270
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52938078
29* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52694437
30UBF1/2_26484160_Chip-Seq_HMECs_Human1.50289207
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45898459
32ZNF263_19887448_ChIP-Seq_K562_Human1.42956170
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36524072
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34547801
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31423821
36BRD4_25478319_ChIP-Seq_HGPS_Human1.29408613
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25554387
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22970733
39* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22577309
40* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.21989653
41* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21977221
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18236676
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17384513
44* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17013824
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12605749
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11135626
47* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09606509
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.09083352
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.07940427
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.05830842
51SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05210978
52* ESR2_21235772_ChIP-Seq_MCF-7_Human1.02970482
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02760633
54SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02077844
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00530182
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.00319883
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99221506
58ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98703567
59* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98069876
60ESR1_21235772_ChIP-Seq_MCF-7_Human0.96527167
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95990726
62TP53_22127205_ChIP-Seq_IMR90_Human0.95586120
63SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93749757
64PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93082510
65TP63_23658742_ChIP-Seq_EP156T_Human0.92179316
66TP53_18474530_ChIP-ChIP_U2OS_Human0.91720497
67* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91523526
68ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91032463
69IRF8_22096565_ChIP-ChIP_GC-B_Human0.90307381
70SA1_22415368_ChIP-Seq_MEFs_Mouse0.90179313
71KDM2B_26808549_Chip-Seq_K562_Human0.89519194
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89315097
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88401777
74* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88112539
75* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87126381
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87103620
77GATA4_25053715_ChIP-Seq_YYC3_Human0.85968619
78* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85518908
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85360698
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84894395
81LXR_22292898_ChIP-Seq_THP-1_Human0.83848403
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.83010379
83TP53_16413492_ChIP-PET_HCT116_Human0.82731403
84* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82007439
85TP63_22573176_ChIP-Seq_HFKS_Human0.81552694
86* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81480588
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80584230
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80364204
89* ELK3_25401928_ChIP-Seq_HUVEC_Human0.80147770
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.78854559
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77701257
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77686546
93TBX20_22328084_ChIP-Seq_HEART_Mouse0.77683995
94TBX20_22080862_ChIP-Seq_HEART_Mouse0.77683995
95RACK7_27058665_Chip-Seq_MCF-7_Human0.77618568
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76757674
97TET1_21490601_ChIP-Seq_MESCs_Mouse0.75779256
98MTF2_20144788_ChIP-Seq_MESCs_Mouse0.75570785
99TP53_23651856_ChIP-Seq_MEFs_Mouse0.74380066
100* ATF3_27146783_Chip-Seq_COLON_Human0.70615605
101ESR1_20079471_ChIP-ChIP_T-47D_Human0.70170305
102* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.69772112
103SOX2_20726797_ChIP-Seq_SW620_Human0.68125215
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65337000
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64757232
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64757232
107P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64596392
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64507215
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.64295169
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.62526660
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.61889877
112CEBPB_22108803_ChIP-Seq_LS180_Human0.61797136
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.59858931
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.59353701
115GATA1_19941826_ChIP-Seq_K562_Human0.59311683
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.58465908
117FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58097632
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.56160243
119* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.55838741
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55732555
121CJUN_26792858_Chip-Seq_BT549_Human0.55360494
122AUTS2_25519132_ChIP-Seq_293T-REX_Human0.55169599
123CSB_26484114_Chip-Seq_FIBROBLAST_Human0.54253972
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.54099070
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.53130410
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.52896340
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.51658572
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51521855
129HTT_18923047_ChIP-ChIP_STHdh_Human0.51385753
130* RARA_24833708_ChIP-Seq_LIVER_Mouse0.51184808
131GATA2_19941826_ChIP-Seq_K562_Human0.51125661
132NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.49389807
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.49115384
134OCT4_18692474_ChIP-Seq_MEFs_Mouse0.48729343
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.48646954
136GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.48506308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.89308378
2MP0005360_urolithiasis5.54073442
3MP0005365_abnormal_bile_salt4.71123870
4MP0005670_abnormal_white_adipose4.58502884
5MP0003950_abnormal_plasma_membrane4.58001584
6MP0005085_abnormal_gallbladder_physiolo4.32419438
7* MP0010329_abnormal_lipoprotein_level3.58254459
8MP0008875_abnormal_xenobiotic_pharmacok3.40707080
9MP0003191_abnormal_cellular_cholesterol2.87489017
10MP0008438_abnormal_cutaneous_collagen2.82854346
11MP0003806_abnormal_nucleotide_metabolis2.76718890
12MP0004130_abnormal_muscle_cell2.74580276
13MP0003252_abnormal_bile_duct2.66745355
14* MP0005666_abnormal_adipose_tissue2.59376484
15MP0009840_abnormal_foam_cell2.51388298
16MP0005332_abnormal_amino_acid2.41784638
17MP0004185_abnormal_adipocyte_glucose2.38423669
18* MP0002118_abnormal_lipid_homeostasis2.28418375
19MP0000609_abnormal_liver_physiology2.21365102
20MP0003705_abnormal_hypodermis_morpholog2.09972422
21MP0002971_abnormal_brown_adipose2.04872427
22MP0003453_abnormal_keratinocyte_physiol1.93783778
23MP0003091_abnormal_cell_migration1.89306181
24MP0004510_myositis1.87720834
25MP0004019_abnormal_vitamin_homeostasis1.84712648
26* MP0005375_adipose_tissue_phenotype1.84435414
27MP0003195_calcinosis1.81701680
28MP0005083_abnormal_biliary_tract1.80751513
29MP0003724_increased_susceptibility_to1.76897308
30MP0010234_abnormal_vibrissa_follicle1.75734567
31MP0001666_abnormal_nutrient_absorption1.74961977
32MP0003011_delayed_dark_adaptation1.74224149
33MP0005319_abnormal_enzyme/_coenzyme1.73358679
34MP0003186_abnormal_redox_activity1.72205568
35MP0005275_abnormal_skin_tensile1.68529558
36MP0005623_abnormal_meninges_morphology1.60285090
37MP0009115_abnormal_fat_cell1.59266307
38MP0010368_abnormal_lymphatic_system1.54950285
39MP0000762_abnormal_tongue_morphology1.54717002
40MP0002254_reproductive_system_inflammat1.52470012
41MP0005334_abnormal_fat_pad1.51037250
42MP0000013_abnormal_adipose_tissue1.45671600
43MP0000579_abnormal_nail_morphology1.43656468
44MP0001958_emphysema1.42208418
45* MP0005584_abnormal_enzyme/coenzyme_acti1.41354651
46MP0000767_abnormal_smooth_muscle1.41077031
47MP0001661_extended_life_span1.37794096
48MP0001764_abnormal_homeostasis1.34789438
49MP0005503_abnormal_tendon_morphology1.33217968
50MP0000003_abnormal_adipose_tissue1.32727421
51MP0009643_abnormal_urine_homeostasis1.32531870
52MP0010030_abnormal_orbit_morphology1.32456203
53MP0002933_joint_inflammation1.29413798
54MP0002876_abnormal_thyroid_physiology1.26666981
55MP0008260_abnormal_autophagy1.26482322
56MP0004272_abnormal_basement_membrane1.25947414
57MP0002332_abnormal_exercise_endurance1.25403068
58MP0002970_abnormal_white_adipose1.25207072
59MP0003075_altered_response_to1.25171092
60MP0002138_abnormal_hepatobiliary_system1.25138695
61MP0001216_abnormal_epidermal_layer1.24977241
62MP0001881_abnormal_mammary_gland1.22329777
63MP0005409_darkened_coat_color1.20043076
64MP0009053_abnormal_anal_canal1.19061911
65MP0000467_abnormal_esophagus_morphology1.16766706
66MP0005165_increased_susceptibility_to1.15112581
67MP0006036_abnormal_mitochondrial_physio1.14811544
68MP0000598_abnormal_liver_morphology1.13923949
69MP0005535_abnormal_body_temperature1.11705519
70MP0002837_dystrophic_cardiac_calcinosis1.10385651
71MP0001542_abnormal_bone_strength1.09015931
72MP0001849_ear_inflammation1.04508902
73MP0002078_abnormal_glucose_homeostasis1.01189275
74MP0003690_abnormal_glial_cell1.00303523
75MP0004782_abnormal_surfactant_physiolog1.00110506
76* MP0009763_increased_sensitivity_to0.99110684
77MP0004947_skin_inflammation0.98780756
78MP0001915_intracranial_hemorrhage0.97817012
79MP0008775_abnormal_heart_ventricle0.96046956
80MP0003303_peritoneal_inflammation0.95303159
81MP0002060_abnormal_skin_morphology0.94951877
82MP0003941_abnormal_skin_development0.94619891
83MP0004233_abnormal_muscle_weight0.94531094
84MP0009764_decreased_sensitivity_to0.92431194
85MP0009278_abnormal_bone_marrow0.92411075
86MP0004858_abnormal_nervous_system0.88572177
87MP0005448_abnormal_energy_balance0.88412539
88MP0010771_integument_phenotype0.88108684
89MP0001756_abnormal_urination0.87502569
90MP0003868_abnormal_feces_composition0.87455634
91MP0005410_abnormal_fertilization0.86325266
92MP0000858_altered_metastatic_potential0.85974189
93MP0005257_abnormal_intraocular_pressure0.85417842
94MP0001545_abnormal_hematopoietic_system0.85246030
95MP0005397_hematopoietic_system_phenotyp0.85246030
96MP0005508_abnormal_skeleton_morphology0.83849923
97MP0001501_abnormal_sleep_pattern0.83358797
98MP0009780_abnormal_chondrocyte_physiolo0.83029066
99MP0005501_abnormal_skin_physiology0.82804526
100MP0003959_abnormal_lean_body0.81982383
101MP0005647_abnormal_sex_gland0.81902528
102MP0002796_impaired_skin_barrier0.81689768
103MP0001299_abnormal_eye_distance/0.78979276
104MP0008469_abnormal_protein_level0.78182204
105MP0009697_abnormal_copulation0.78040284
106MP0003656_abnormal_erythrocyte_physiolo0.77431548
107MP0005164_abnormal_response_to0.76999104
108MP0005166_decreased_susceptibility_to0.76263192
109MP0003300_gastrointestinal_ulcer0.75440801
110MP0005451_abnormal_body_composition0.75249844
111MP0002998_abnormal_bone_remodeling0.74638514
112MP0005376_homeostasis/metabolism_phenot0.74306674
113MP0000604_amyloidosis0.73452144
114* MP0009642_abnormal_blood_homeostasis0.73317820
115MP0003828_pulmonary_edema0.73076041
116MP0003448_altered_tumor_morphology0.72817649
117MP0003566_abnormal_cell_adhesion0.72804987
118MP0009931_abnormal_skin_appearance0.70832469
119MP0000749_muscle_degeneration0.69843674
120MP0000750_abnormal_muscle_regeneration0.68480944
121MP0005636_abnormal_mineral_homeostasis0.68095193
122MP0000343_altered_response_to0.67820038
123MP0005023_abnormal_wound_healing0.66784518
124MP0006054_spinal_hemorrhage0.66070384
125MP0010678_abnormal_skin_adnexa0.65892624
126MP0000249_abnormal_blood_vessel0.65670944
127MP0006138_congestive_heart_failure0.65555033
128MP0001614_abnormal_blood_vessel0.65332757
129MP0002896_abnormal_bone_mineralization0.65228011
130MP0001851_eye_inflammation0.63449173
131MP0002168_other_aberrant_phenotype0.62992745
132MP0004147_increased_porphyrin_level0.62721038
133MP0009384_cardiac_valve_regurgitation0.62242739
134MP0002136_abnormal_kidney_physiology0.59854857
135MP0003279_aneurysm0.59224186
136MP0001853_heart_inflammation0.58399361
137MP0002295_abnormal_pulmonary_circulatio0.57400446
138MP0005266_abnormal_metabolism0.57240721
139MP0005167_abnormal_blood-brain_barrier0.57231287
140* MP0005452_abnormal_adipose_tissue0.57018230
141MP0001243_abnormal_dermal_layer0.56560409
142MP0009765_abnormal_xenobiotic_induced0.56131346
143* MP0001879_abnormal_lymphatic_vessel0.55904442
144MP0005330_cardiomyopathy0.52056092
145MP0005595_abnormal_vascular_smooth0.50387371
146MP0000230_abnormal_systemic_arterial0.49179832
147MP0001544_abnormal_cardiovascular_syste0.48524588
148MP0005385_cardiovascular_system_phenoty0.48524588
149MP0005058_abnormal_lysosome_morphology0.47969393
150MP0003953_abnormal_hormone_level0.47670655
151MP0005395_other_phenotype0.47496217
152MP0005084_abnormal_gallbladder_morpholo0.46930124
153MP0004883_abnormal_blood_vessel0.46774348
154MP0001533_abnormal_skeleton_physiology0.46772557

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)5.61285084
2Deep venous thrombosis (HP:0002625)5.60962186
3Hyperglycinuria (HP:0003108)5.23751804
4Atrophic scars (HP:0001075)5.13844234
5Complement deficiency (HP:0004431)5.08241541
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.01454629
7Intrahepatic cholestasis (HP:0001406)4.88851535
8Hyperlipoproteinemia (HP:0010980)4.86031685
9Abnormality of glycine metabolism (HP:0010895)4.67690502
10Abnormality of serine family amino acid metabolism (HP:0010894)4.67690502
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.57578043
12Hyperammonemia (HP:0001987)4.51489111
13Hypoglycemic coma (HP:0001325)4.44923144
14Hypoalphalipoproteinemia (HP:0003233)4.43370193
15Prolonged partial thromboplastin time (HP:0003645)4.34593501
16Hypobetalipoproteinemia (HP:0003563)4.33740387
17Abnormality of fatty-acid metabolism (HP:0004359)4.24470892
18Milia (HP:0001056)4.20078263
19Hyperglycinemia (HP:0002154)4.19123442
20Epidermoid cyst (HP:0200040)4.18247641
21Hypolipoproteinemia (HP:0010981)4.16547552
22Axonal loss (HP:0003447)4.11788531
23Cervical subluxation (HP:0003308)4.11566557
24Ketosis (HP:0001946)4.09262817
25Follicular hyperkeratosis (HP:0007502)4.07627789
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.07082436
27Onycholysis (HP:0001806)3.98942369
28Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85767003
29Plantar hyperkeratosis (HP:0007556)3.83760342
30Abnormality of complement system (HP:0005339)3.79492717
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.79337057
32Fragile nails (HP:0001808)3.71572597
33Thick nail (HP:0001805)3.65720717
34Abnormality of nail color (HP:0100643)3.62051112
35Hypertriglyceridemia (HP:0002155)3.49810436
36Alopecia of scalp (HP:0002293)3.42267283
37Abnormality of dicarboxylic acid metabolism (HP:0010995)3.37322661
38Dicarboxylic aciduria (HP:0003215)3.37322661
39Joint hemorrhage (HP:0005261)3.35172446
40Abnormality of the common coagulation pathway (HP:0010990)3.30786156
41Myocardial infarction (HP:0001658)3.29234280
42Hypercholesterolemia (HP:0003124)3.25872883
43Ketoacidosis (HP:0001993)3.24310381
44Vascular tortuosity (HP:0004948)3.23361989
45Abnormality of aspartate family amino acid metabolism (HP:0010899)3.15915264
46Arterial tortuosity (HP:0005116)3.15347913
47Oligomenorrhea (HP:0000876)3.13822586
48Nail dystrophy (HP:0008404)3.10644849
49Acanthosis nigricans (HP:0000956)3.06131314
50Fragile skin (HP:0001030)3.04554789
51Hydroxyprolinuria (HP:0003080)3.00898655
52Abnormality of proline metabolism (HP:0010907)3.00898655
53Palmoplantar hyperkeratosis (HP:0000972)3.00165754
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.96923676
55Abnormality of the intrinsic pathway (HP:0010989)2.94661578
56Skin nodule (HP:0200036)2.92919382
57Abnormality of serum amino acid levels (HP:0003112)2.86662375
58Abnormality of purine metabolism (HP:0004352)2.83715102
59Abnormality of methionine metabolism (HP:0010901)2.79443519
60Vertebral compression fractures (HP:0002953)2.74877515
61Palmar hyperkeratosis (HP:0010765)2.74616406
62Nausea (HP:0002018)2.72888405
63Blue sclerae (HP:0000592)2.72683950
64Fat malabsorption (HP:0002630)2.66510648
65Abnormal cartilage morphology (HP:0002763)2.65434863
66Generalized aminoaciduria (HP:0002909)2.64927554
67Abnormality of nucleobase metabolism (HP:0010932)2.63380786
68Myoglobinuria (HP:0002913)2.62957199
69Lethargy (HP:0001254)2.61278893
70Nuclear cataract (HP:0100018)2.60643047
71Spinal rigidity (HP:0003306)2.52182588
72Metabolic acidosis (HP:0001942)2.51430297
73Systemic lupus erythematosus (HP:0002725)2.49860767
74Short nail (HP:0001799)2.49546919
75Abnormality of the costochondral junction (HP:0000919)2.46929009
76Hemorrhage of the eye (HP:0011885)2.46398038
77Right ventricular cardiomyopathy (HP:0011663)2.43335734
78Aortic dissection (HP:0002647)2.42821699
79Hepatocellular carcinoma (HP:0001402)2.42397378
80Ankle contracture (HP:0006466)2.41247635
81Wormian bones (HP:0002645)2.40759700
82Rhabdomyolysis (HP:0003201)2.40359037
83Pancreatitis (HP:0001733)2.38473059
84Delayed CNS myelination (HP:0002188)2.38154452
85Corneal dystrophy (HP:0001131)2.37723289
86Amyloidosis (HP:0011034)2.32127314
87Esophageal varix (HP:0002040)2.31245955
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.31203463
89Abnormality of glycolipid metabolism (HP:0010969)2.31203463
90Abnormality of liposaccharide metabolism (HP:0010968)2.31203463
91Hyperbilirubinemia (HP:0002904)2.29659378
92Soft skin (HP:0000977)2.29399857
93Recurrent corneal erosions (HP:0000495)2.29177084
94Abnormality of pyrimidine metabolism (HP:0004353)2.22712155
95Spastic diplegia (HP:0001264)2.22424401
96Vomiting (HP:0002013)2.19753721
97Natal tooth (HP:0000695)2.18624358
98Cerebral edema (HP:0002181)2.18038362
99Insulin resistance (HP:0000855)2.16788427
100Spinal cord compression (HP:0002176)2.15188242
101Abnormal blistering of the skin (HP:0008066)2.15003636
102Gout (HP:0001997)2.14390218
103Cholecystitis (HP:0001082)2.14337032
104Abnormal gallbladder physiology (HP:0012438)2.14337032
105Increased muscle lipid content (HP:0009058)2.09370328
106Cardiovascular calcification (HP:0011915)2.08442197
107Protrusio acetabuli (HP:0003179)2.07848549
108Proximal tubulopathy (HP:0000114)2.07800613
109Mildly elevated creatine phosphokinase (HP:0008180)2.07226651
110Nonimmune hydrops fetalis (HP:0001790)2.06459886
111Vascular calcification (HP:0004934)2.06392611
112Hypoglycemic seizures (HP:0002173)2.06272417
113Increased purine levels (HP:0004368)2.06230679
114Hyperuricemia (HP:0002149)2.06230679
115Mitral stenosis (HP:0001718)2.04791687
116Renal duplication (HP:0000075)2.02455601
117Type 1 muscle fiber predominance (HP:0003803)2.02193295
118Brushfield spots (HP:0001088)2.02131328
119Multiple enchondromatosis (HP:0005701)2.01827807
120Pigmentary retinal degeneration (HP:0001146)2.01453137
121Premature rupture of membranes (HP:0001788)2.00810794
122Increased serum pyruvate (HP:0003542)1.99491730
123Cholelithiasis (HP:0001081)1.98888699
124Spontaneous abortion (HP:0005268)1.98094944
125Abnormality of glycolysis (HP:0004366)1.98058841
126Abnormality of carpal bone ossification (HP:0006257)1.97586706
127Increased connective tissue (HP:0009025)1.96735419
128Parakeratosis (HP:0001036)1.96296356
129Bladder diverticulum (HP:0000015)1.95618334
130Steatorrhea (HP:0002570)1.95109594
131Shallow orbits (HP:0000586)1.94688355
132Abnormal gallbladder morphology (HP:0012437)1.94634472
133Hyperglycemia (HP:0003074)1.94458683
134Generalized amyotrophy (HP:0003700)1.94245260
135Increased variability in muscle fiber diameter (HP:0003557)1.93540695
136Corneal erosion (HP:0200020)1.93070162
137Conjugated hyperbilirubinemia (HP:0002908)1.91846967
138Renal cortical cysts (HP:0000803)1.91814504
139Asymmetric septal hypertrophy (HP:0001670)1.89760844
140Sensorimotor neuropathy (HP:0007141)1.86709879
141Bone cyst (HP:0012062)1.86209889
142Polycythemia (HP:0001901)1.85511209
143Tetraparesis (HP:0002273)1.83163793
144Elbow flexion contracture (HP:0002987)1.82928673
145Aortic valve stenosis (HP:0001650)1.82927696
146Neonatal onset (HP:0003623)1.82762218
147Peritonitis (HP:0002586)1.82645104
148Broad metatarsal (HP:0001783)1.82463391
149Neurofibrillary tangles (HP:0002185)1.82427301
150Nephritis (HP:0000123)1.81937807
151Malnutrition (HP:0004395)1.81346445
152Elevated hepatic transaminases (HP:0002910)1.80699290
153Irritability (HP:0000737)1.79715737
154Cerebral aneurysm (HP:0004944)1.79324890
155Metaphyseal dysplasia (HP:0100255)1.79188621
156Joint stiffness (HP:0001387)1.79045016
157Ridged nail (HP:0001807)1.78753276
158Abnormality of iron homeostasis (HP:0011031)1.78371290
159Delayed gross motor development (HP:0002194)1.78283763
160Glomerulonephritis (HP:0000099)1.77823201
161Hyperextensible skin (HP:0000974)1.77541799
162Amniotic constriction ring (HP:0009775)1.77109265
163Abnormality of placental membranes (HP:0011409)1.77109265
164Hypoplasia of dental enamel (HP:0006297)1.76945639
165Congenital ichthyosiform erythroderma (HP:0007431)1.76733417
166Ectropion (HP:0000656)1.76681521
167Reduced subcutaneous adipose tissue (HP:0003758)1.75288219
168Abnormality of dentin (HP:0010299)1.72768779
169Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.72661403
170Pulmonary artery stenosis (HP:0004415)1.72252822
171Muscle stiffness (HP:0003552)1.71762329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.68600802
2TRIB34.37226426
3ERN14.36433225
4SIK14.00705356
5KDR3.82561439
6ARAF3.72283274
7CAMK1D3.16313489
8FGFR43.02004409
9MOS2.79511873
10TIE12.56108772
11MAP3K132.41880637
12STK242.26016567
13TGFBR22.17760520
14PIM22.16710411
15MST1R2.15456572
16MAP3K92.15051553
17NTRK12.13405251
18TESK12.12110115
19PDK42.05356151
20PDK32.05356151
21PKN21.99347088
22CAMK1G1.96539086
23RIPK11.79719094
24LATS11.75094342
25NEK91.57995085
26INSRR1.57350074
27PRKAA21.49560360
28PDK21.46930551
29PDGFRA1.35813585
30FLT31.31425278
31MAPK111.25058815
32PTK61.23528291
33ERBB41.21968837
34JAK11.21440505
35CDK61.18237270
36ABL21.17243974
37FRK1.15401056
38EPHB21.06029336
39MAP3K31.05536772
40JAK21.05270510
41BRAF1.04049874
42MET1.03960594
43FGFR31.02050446
44TYK21.00149046
45MAP2K30.99329141
46EPHA20.97888008
47MAP4K20.97669019
48CLK10.96384149
49EPHB10.96076675
50CDK90.95735982
51GRK50.93789153
52EPHA30.93401502
53MAP2K10.92721655
54MYLK0.92083872
55PIK3CG0.89377805
56ADRBK10.88689489
57KSR20.87264814
58TAOK20.87163935
59FGFR20.87122653
60GRK70.86315954
61TBK10.79736807
62FER0.79246216
63LATS20.78366796
64STK38L0.76471824
65GSK3A0.74982757
66MAP3K120.73937654
67PRPF4B0.72784325
68LIMK10.72651181
69IRAK30.72518796
70TTN0.70285013
71CDK40.66141412
72MAP3K110.64296550
73CSK0.63958783
74MTOR0.63157592
75PHKG10.63134731
76PHKG20.63134731
77MAP3K100.62450311
78MAP2K40.62410857
79MAP3K60.60066811
80MAPK150.59968900
81MAPK120.59895935
82STK380.59638442
83PAK20.59543445
84TGFBR10.59187073
85PRKAA10.59181922
86DDR20.59171055
87IGF1R0.59070369
88RAF10.58739686
89JAK30.57980923
90LRRK20.57874042
91NME20.57574665
92MAP3K70.57117116
93MAPK40.57045929
94LMTK20.56973696
95PDPK10.56804520
96TRPM70.56459323
97PTK20.55990372
98CDC42BPA0.55984811
99DAPK30.55822262
100IKBKB0.54391802
101TAOK30.54144325
102BMX0.53784650
103GRK10.52713880
104PRKACG0.51165512
105MAP3K10.50233450
106MAPK70.47672871
107STK30.47576870
108PIK3CA0.46770207
109MAPKAPK30.45097484
110DAPK20.44908271
111AKT30.43925851
112PINK10.42832613
113FGFR10.40517477
114RET0.39954084
115MAP2K60.39824396
116MUSK0.39089435
117PRKG20.37969751
118ROCK10.37365491
119INSR0.36461746
120RPS6KA40.36381963
121PTK2B0.34999902
122PAK60.34771228
123ILK0.34767807
124KSR10.34036509
125PDGFRB0.33858241
126KIT0.33536638
127STK100.32016819
128PDK10.31618873
129PRKD20.31320663
130ZAP700.31299171
131CSF1R0.30673986
132PRKCH0.30527919
133PRKD10.29788198
134MAP2K20.29326954
135ROCK20.28838090
136PAK40.28246253
137ERBB20.28205688
138PRKCZ0.27854829
139ABL10.27583246
140CAMK2G0.27322966
141PRKCE0.25833021
142MAP3K140.24444051
143PAK10.22177495
144RPS6KA20.21293602

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.55728688
2Fatty acid degradation_Homo sapiens_hsa000713.20729842
3Nitrogen metabolism_Homo sapiens_hsa009103.16277909
4Propanoate metabolism_Homo sapiens_hsa006403.06964743
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.06712681
6Mineral absorption_Homo sapiens_hsa049783.04492971
7* PPAR signaling pathway_Homo sapiens_hsa033202.97525911
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.80473903
9Fatty acid metabolism_Homo sapiens_hsa012122.71901636
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.65976525
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.56181234
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46332707
13Arginine biosynthesis_Homo sapiens_hsa002202.45748324
14Complement and coagulation cascades_Homo sapiens_hsa046102.41005286
15Tryptophan metabolism_Homo sapiens_hsa003802.37235112
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.29333627
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26203127
18Caffeine metabolism_Homo sapiens_hsa002322.20347308
19Peroxisome_Homo sapiens_hsa041462.16893715
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14041500
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.02236671
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99143595
23Butanoate metabolism_Homo sapiens_hsa006501.99114883
24beta-Alanine metabolism_Homo sapiens_hsa004101.95153323
25Fatty acid biosynthesis_Homo sapiens_hsa000611.92525060
26Pyruvate metabolism_Homo sapiens_hsa006201.87874757
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.83741805
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67615249
29Carbon metabolism_Homo sapiens_hsa012001.67569629
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63584794
31Staphylococcus aureus infection_Homo sapiens_hsa051501.59025764
32Fatty acid elongation_Homo sapiens_hsa000621.57593314
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54512347
34Chemical carcinogenesis_Homo sapiens_hsa052041.52243855
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.45696993
36Phenylalanine metabolism_Homo sapiens_hsa003601.44372014
37Fat digestion and absorption_Homo sapiens_hsa049751.43882753
38Glycerolipid metabolism_Homo sapiens_hsa005611.36299782
39Retinol metabolism_Homo sapiens_hsa008301.35028927
40TNF signaling pathway_Homo sapiens_hsa046681.34372112
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.33846045
42Pertussis_Homo sapiens_hsa051331.32134862
43Histidine metabolism_Homo sapiens_hsa003401.29916069
44Tyrosine metabolism_Homo sapiens_hsa003501.28037628
45Other glycan degradation_Homo sapiens_hsa005111.24530621
46Bile secretion_Homo sapiens_hsa049761.23701746
47Biosynthesis of amino acids_Homo sapiens_hsa012301.23214342
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19967690
49Selenocompound metabolism_Homo sapiens_hsa004501.19680556
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19496210
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18487397
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18387909
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18349886
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16249921
55Starch and sucrose metabolism_Homo sapiens_hsa005001.16131310
56Circadian rhythm_Homo sapiens_hsa047101.11121878
57Proteoglycans in cancer_Homo sapiens_hsa052051.07427405
58African trypanosomiasis_Homo sapiens_hsa051431.03892305
59ABC transporters_Homo sapiens_hsa020101.02752367
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02333364
61HIF-1 signaling pathway_Homo sapiens_hsa040661.01990552
62Folate biosynthesis_Homo sapiens_hsa007901.00687852
63Pentose phosphate pathway_Homo sapiens_hsa000300.99179037
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.98998871
65Vitamin B6 metabolism_Homo sapiens_hsa007500.98482128
66Sulfur metabolism_Homo sapiens_hsa009200.95057367
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94996701
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.92777720
69Sulfur relay system_Homo sapiens_hsa041220.92686026
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89680902
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87180718
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85273660
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85114625
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.82475788
75Lysine degradation_Homo sapiens_hsa003100.82460304
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82354994
77Vitamin digestion and absorption_Homo sapiens_hsa049770.81447105
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77774975
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77421973
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77175118
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73787580
82Glutathione metabolism_Homo sapiens_hsa004800.73381264
83Salmonella infection_Homo sapiens_hsa051320.73043147
84Sphingolipid metabolism_Homo sapiens_hsa006000.71625516
85Dilated cardiomyopathy_Homo sapiens_hsa054140.70587762
86Shigellosis_Homo sapiens_hsa051310.68002845
87Rheumatoid arthritis_Homo sapiens_hsa053230.67700917
88Arginine and proline metabolism_Homo sapiens_hsa003300.64758766
89AMPK signaling pathway_Homo sapiens_hsa041520.64619451
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.61120142
91Insulin resistance_Homo sapiens_hsa049310.61001551
92Toxoplasmosis_Homo sapiens_hsa051450.59908523
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57244731
94Vibrio cholerae infection_Homo sapiens_hsa051100.57135002
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56810013
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53380188
97Steroid biosynthesis_Homo sapiens_hsa001000.53111004
98Adherens junction_Homo sapiens_hsa045200.52808397
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50179891
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.47587040
101VEGF signaling pathway_Homo sapiens_hsa043700.45540378
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45102274
103Metabolic pathways_Homo sapiens_hsa011000.43657879
104Fructose and mannose metabolism_Homo sapiens_hsa000510.41230707
105Pathways in cancer_Homo sapiens_hsa052000.40083941
106One carbon pool by folate_Homo sapiens_hsa006700.38445766
107Legionellosis_Homo sapiens_hsa051340.37753395
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.37405030
109Galactose metabolism_Homo sapiens_hsa000520.35924670
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33968113
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.31377585
112Glucagon signaling pathway_Homo sapiens_hsa049220.31020512
113Insulin signaling pathway_Homo sapiens_hsa049100.24923844
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23212280
115ECM-receptor interaction_Homo sapiens_hsa045120.19191857
116Prion diseases_Homo sapiens_hsa050200.18651851
117Protein digestion and absorption_Homo sapiens_hsa049740.11292804
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10838648
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.10310457
120Linoleic acid metabolism_Homo sapiens_hsa005910.08258374
121Malaria_Homo sapiens_hsa051440.04818256
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04036630
123Renin-angiotensin system_Homo sapiens_hsa046140.03474515
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.00501086
125Thyroid cancer_Homo sapiens_hsa05216-0.1170372
126Small cell lung cancer_Homo sapiens_hsa05222-0.1165463
127PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.1146841
128Lysosome_Homo sapiens_hsa04142-0.1064859
129Hepatitis C_Homo sapiens_hsa05160-0.0773388
130Bladder cancer_Homo sapiens_hsa05219-0.0727628
131Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0569976
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0544250
133Focal adhesion_Homo sapiens_hsa04510-0.0491610
134Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0454103
135Amoebiasis_Homo sapiens_hsa05146-0.0344121
136Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0211076

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