ANGPT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thyroid hormone generation (GO:0006590)9.08448875
2endocrine hormone secretion (GO:0060986)8.97290037
3thyroid hormone metabolic process (GO:0042403)7.90949063
4collagen fibril organization (GO:0030199)6.13114726
5adhesion of symbiont to host cell (GO:0044650)5.97629536
6virion attachment to host cell (GO:0019062)5.97629536
7protein heterotrimerization (GO:0070208)5.84384768
8negative regulation of organ growth (GO:0046621)4.88431629
9adhesion of symbiont to host (GO:0044406)4.82523671
10cell adhesion mediated by integrin (GO:0033627)4.80495367
11cellular response to vitamin (GO:0071295)4.79993756
12blood vessel maturation (GO:0001955)4.71970938
13bone trabecula formation (GO:0060346)4.48919428
14central nervous system myelination (GO:0022010)4.42603002
15axon ensheathment in central nervous system (GO:0032291)4.42603002
16extracellular matrix assembly (GO:0085029)4.39899202
17thyroid gland development (GO:0030878)4.39181917
18chondrocyte proliferation (GO:0035988)4.36621224
19estrogen biosynthetic process (GO:0006703)4.34748926
20skin morphogenesis (GO:0043589)4.30164930
21sprouting angiogenesis (GO:0002040)4.30086991
22alanine transport (GO:0032328)4.22630326
23collagen catabolic process (GO:0030574)4.19483504
24sequestering of extracellular ligand from receptor (GO:0035581)4.17856928
25collagen metabolic process (GO:0032963)4.17480989
26endodermal cell differentiation (GO:0035987)4.11199305
27opsonization (GO:0008228)3.97604453
28peptide hormone processing (GO:0016486)3.96338621
29negative regulation of complement activation (GO:0045916)3.94663317
30peptidyl-proline hydroxylation (GO:0019511)3.92682941
31multicellular organismal macromolecule metabolic process (GO:0044259)3.88885274
32cellular response to vitamin D (GO:0071305)3.87742210
33negative regulation of transcription regulatory region DNA binding (GO:2000678)3.86885199
34ensheathment of neurons (GO:0007272)3.86816957
35axon ensheathment (GO:0008366)3.86816957
36multicellular organismal catabolic process (GO:0044243)3.84240115
37myelination (GO:0042552)3.80894516
38multicellular organismal metabolic process (GO:0044236)3.67240910
39cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.65204911
40regulation of cilium movement (GO:0003352)3.64056626
41extracellular matrix disassembly (GO:0022617)3.56607053
42detection of light stimulus involved in visual perception (GO:0050908)3.53975569
43detection of light stimulus involved in sensory perception (GO:0050962)3.53975569
44protein K11-linked deubiquitination (GO:0035871)3.42990451
45retina vasculature morphogenesis in camera-type eye (GO:0061299)3.42838240
46positive regulation of meiotic cell cycle (GO:0051446)3.42043172
47positive regulation of hair follicle development (GO:0051798)3.41878895
48positive regulation of hair cycle (GO:0042635)3.41878895
49myelin maintenance (GO:0043217)3.39904438
50negative regulation of activin receptor signaling pathway (GO:0032926)3.39407159
51endothelial cell morphogenesis (GO:0001886)3.39324323
52membrane raft organization (GO:0031579)3.35353525
53mesenchymal-epithelial cell signaling (GO:0060638)3.33620344
54axoneme assembly (GO:0035082)3.32479454
55apoptotic cell clearance (GO:0043277)3.31634245
56cytoskeletal anchoring at plasma membrane (GO:0007016)3.31607669
57astrocyte development (GO:0014002)3.30685743
58keratan sulfate catabolic process (GO:0042340)3.29620975
59inositol phosphate catabolic process (GO:0071545)3.27967938
60response to insecticide (GO:0017085)3.26415944
61fucose catabolic process (GO:0019317)3.25921879
62L-fucose metabolic process (GO:0042354)3.25921879
63L-fucose catabolic process (GO:0042355)3.25921879
64wound healing, spreading of cells (GO:0044319)3.25089064
65leukocyte migration involved in inflammatory response (GO:0002523)3.22293031
66polyol catabolic process (GO:0046174)3.21563089
67basement membrane organization (GO:0071711)3.21219595
68positive regulation of osteoblast proliferation (GO:0033690)3.20359564
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.20243261
70renal filtration (GO:0097205)3.18716787
71platelet dense granule organization (GO:0060155)3.17659557
72negative regulation of telomere maintenance (GO:0032205)3.16585903
73platelet-derived growth factor receptor signaling pathway (GO:0048008)3.15926115
74import into cell (GO:0098657)3.15514460
75negative regulation of protein activation cascade (GO:2000258)3.15509446
76protein targeting to plasma membrane (GO:0072661)3.12059016
77dermatan sulfate biosynthetic process (GO:0030208)3.11343701
78protein localization to endosome (GO:0036010)3.10984135
79keratinocyte development (GO:0003334)3.10696034
80muscle cell migration (GO:0014812)3.10065334
81mesodermal cell differentiation (GO:0048333)3.09646037
82cortical actin cytoskeleton organization (GO:0030866)3.07449959
83chondrocyte development (GO:0002063)3.06069868
84extracellular matrix organization (GO:0030198)3.03901563
85wound healing, spreading of epidermal cells (GO:0035313)3.03832043
86extracellular structure organization (GO:0043062)3.02476198
87positive regulation of meiosis (GO:0045836)3.02410519
88glycerophospholipid catabolic process (GO:0046475)3.00549597
89protein polyglutamylation (GO:0018095)2.99331823
90regulation of glucokinase activity (GO:0033131)2.98545499
91regulation of hexokinase activity (GO:1903299)2.98545499
92inositol phosphate dephosphorylation (GO:0046855)2.95926630
93phosphorylated carbohydrate dephosphorylation (GO:0046838)2.95926630
94extracellular fibril organization (GO:0043206)2.93038386
95protein localization to cell surface (GO:0034394)2.91952948
96axon extension involved in axon guidance (GO:0048846)2.91701163
97neuron projection extension involved in neuron projection guidance (GO:1902284)2.91701163
98glomerular filtration (GO:0003094)2.90655658
99basic amino acid transport (GO:0015802)2.90630239
100positive regulation of endothelial cell apoptotic process (GO:2000353)2.89846962
101protein-cofactor linkage (GO:0018065)2.88059753
102endocardial cushion development (GO:0003197)2.88040425
103behavioral response to nicotine (GO:0035095)2.88023182
104proline transport (GO:0015824)2.87653362
105metanephric mesenchyme development (GO:0072075)2.87643779
106L-alpha-amino acid transmembrane transport (GO:1902475)2.87307054
107indolalkylamine metabolic process (GO:0006586)2.87280121
108heme transport (GO:0015886)2.86998123
109cellular response to amino acid stimulus (GO:0071230)2.85900624
110piRNA metabolic process (GO:0034587)2.85032695
111preassembly of GPI anchor in ER membrane (GO:0016254)2.84778845
112interleukin-6-mediated signaling pathway (GO:0070102)2.84517164
113cornea development in camera-type eye (GO:0061303)2.82361104
114respiratory chain complex IV assembly (GO:0008535)2.82332135
115glycerol ether metabolic process (GO:0006662)2.80843162
116prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.80213796
117dermatan sulfate metabolic process (GO:0030205)2.78975131
118cellular response to interferon-alpha (GO:0035457)2.78338652
119protein hydroxylation (GO:0018126)2.76587387
120detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.76558425
121ether metabolic process (GO:0018904)2.76489097
122response to pheromone (GO:0019236)2.75661889
123cortical cytoskeleton organization (GO:0030865)2.75062330
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73616072
125fibril organization (GO:0097435)2.73026195
126cell-matrix adhesion (GO:0007160)2.71150806
127regulation of osteoblast proliferation (GO:0033688)2.71000243
128negative regulation of leukocyte chemotaxis (GO:0002689)2.69905771
129craniofacial suture morphogenesis (GO:0097094)2.69059165
130regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67951086
131mannosylation (GO:0097502)2.67276700
132tryptophan catabolic process (GO:0006569)2.67239438
133indole-containing compound catabolic process (GO:0042436)2.67239438
134indolalkylamine catabolic process (GO:0046218)2.67239438
135dopamine transport (GO:0015872)2.67018275
136benzene-containing compound metabolic process (GO:0042537)2.66757169
137protein localization to cilium (GO:0061512)2.66060328
138positive regulation of macrophage activation (GO:0043032)2.65731469
139kidney mesenchyme development (GO:0072074)2.65524903
140mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65175127
141mitochondrial respiratory chain complex I assembly (GO:0032981)2.65175127
142NADH dehydrogenase complex assembly (GO:0010257)2.65175127
143cellular response to ATP (GO:0071318)2.64871339
144positive regulation of mitochondrial fission (GO:0090141)2.63396581
145epithelial cell-cell adhesion (GO:0090136)2.63077275
146negative regulation of mast cell activation (GO:0033004)2.63043112
147asymmetric protein localization (GO:0008105)2.60309893
148positive regulation of Rho protein signal transduction (GO:0035025)2.59521230
149pathway-restricted SMAD protein phosphorylation (GO:0060389)2.58341246
150creatine metabolic process (GO:0006600)2.57632706
151phosphatidylinositol acyl-chain remodeling (GO:0036149)2.55482019
152cell-substrate adhesion (GO:0031589)2.55451171
153membrane protein ectodomain proteolysis (GO:0006509)2.55450127
154male meiosis (GO:0007140)2.54908506
155protein complex biogenesis (GO:0070271)2.54478994
156negative regulation of catenin import into nucleus (GO:0035414)2.53723652
157photoreceptor cell maintenance (GO:0045494)2.53349805
158ER overload response (GO:0006983)2.51905560
159myelination in peripheral nervous system (GO:0022011)2.51655440
160peripheral nervous system axon ensheathment (GO:0032292)2.51655440
161apical protein localization (GO:0045176)2.51163745
162C4-dicarboxylate transport (GO:0015740)2.50341726
163tachykinin receptor signaling pathway (GO:0007217)2.49925265
164wound healing (GO:0042060)2.49439110
165fatty acid elongation (GO:0030497)2.49306871
166cellular response to nutrient (GO:0031670)2.49220290
167regulation of DNA endoreduplication (GO:0032875)2.49077627
168iron coordination entity transport (GO:1901678)2.49010147
169branching involved in prostate gland morphogenesis (GO:0060442)2.48964529
170multicellular organism reproduction (GO:0032504)2.48587915
171maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.48013753
172estrogen metabolic process (GO:0008210)2.47934087
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47443062
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47336735
175actin filament depolymerization (GO:0030042)2.46896951
176negative regulation of epidermal cell differentiation (GO:0045605)2.46635973
177hormone secretion (GO:0046879)2.46434259
178endochondral ossification (GO:0001958)2.46392880
179replacement ossification (GO:0036075)2.46392880
180serine family amino acid catabolic process (GO:0009071)2.45502478
181L-methionine salvage (GO:0071267)2.43834856
182L-methionine biosynthetic process (GO:0071265)2.43834856
183amino acid salvage (GO:0043102)2.43834856
184reflex (GO:0060004)2.43267281
185retinal cone cell development (GO:0046549)2.41711381
186epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.40965805
187kynurenine metabolic process (GO:0070189)2.38941645
188phenol-containing compound metabolic process (GO:0018958)2.38919314
189organic cation transport (GO:0015695)2.38389648
190branching involved in ureteric bud morphogenesis (GO:0001658)2.36981944
191phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.36708093
192photoreceptor cell development (GO:0042461)2.36385595
193anterograde synaptic vesicle transport (GO:0048490)2.35821812
194response to nitrosative stress (GO:0051409)2.34873581
195mitochondrial respiratory chain complex assembly (GO:0033108)2.34368658
196protein K6-linked ubiquitination (GO:0085020)2.34354582
197cellular ketone body metabolic process (GO:0046950)2.34319568
198C-terminal protein lipidation (GO:0006501)2.34246240
199nonmotile primary cilium assembly (GO:0035058)2.33871823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.42504328
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.46970527
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.81667801
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.73059471
5ZNF274_21170338_ChIP-Seq_K562_Hela3.69611490
6WT1_19549856_ChIP-ChIP_CCG9911_Human3.30424654
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.02893155
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62477621
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62450967
10CLOCK_20551151_ChIP-Seq_293T_Human2.57702863
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.53176043
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51519453
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.46434947
14NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.45848380
15NRF2_20460467_ChIP-Seq_MEFs_Mouse2.45848380
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.43442244
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.41209142
18VDR_22108803_ChIP-Seq_LS180_Human2.38580975
19SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38295734
20CJUN_26792858_Chip-Seq_BT549_Human2.35154561
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29624683
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.27566172
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26954197
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24552317
25IGF1R_20145208_ChIP-Seq_DFB_Human2.24402015
26CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23609197
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22558240
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.17387121
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14652139
30EP300_21415370_ChIP-Seq_HL-1_Mouse2.13306771
31* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.10398311
32CBP_20019798_ChIP-Seq_JUKART_Human2.07035064
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.07035064
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.05410250
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05175561
36CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03379705
37FUS_26573619_Chip-Seq_HEK293_Human2.01175050
38P300_19829295_ChIP-Seq_ESCs_Human1.99383796
39EWS_26573619_Chip-Seq_HEK293_Human1.94956833
40TAF15_26573619_Chip-Seq_HEK293_Human1.92854416
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92024079
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89646627
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89238615
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82247633
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80130605
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.77491156
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.74709859
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.74121235
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73368381
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72301612
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.71453141
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70345074
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70345074
54SOX2_20726797_ChIP-Seq_SW620_Human1.69642796
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68976941
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.68469173
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66317264
58BCAT_22108803_ChIP-Seq_LS180_Human1.66154769
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63784094
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61507989
61SMAD4_21799915_ChIP-Seq_A2780_Human1.59098200
62STAT3_23295773_ChIP-Seq_U87_Human1.56990280
63TCF4_23295773_ChIP-Seq_U87_Human1.56806657
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56212021
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.55794908
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52507653
67IRF1_19129219_ChIP-ChIP_H3396_Human1.50792962
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50660588
69TP53_22573176_ChIP-Seq_HFKS_Human1.49439966
70AR_25329375_ChIP-Seq_VCAP_Human1.48811424
71TCF4_22108803_ChIP-Seq_LS180_Human1.48799497
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48694706
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47513292
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47401233
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46362462
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.45989729
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44186969
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.42607536
79RNF2_27304074_Chip-Seq_NSC_Mouse1.42287421
80BRD4_25478319_ChIP-Seq_HGPS_Human1.41821970
81TP53_18474530_ChIP-ChIP_U2OS_Human1.41301119
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.40952069
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40305874
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.39399036
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38999542
86TP53_16413492_ChIP-PET_HCT116_Human1.37651144
87GBX2_23144817_ChIP-Seq_PC3_Human1.37420910
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36655147
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35988000
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35934041
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.34715734
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.33664925
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33664925
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33515890
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33490791
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32130062
97RUNX2_22187159_ChIP-Seq_PCA_Human1.31478317
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.30918156
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30394907
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30394907
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29262640
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28798664
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28726840
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28111744
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27689897
106SMAD4_21741376_ChIP-Seq_EPCs_Human1.27450638
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26405526
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26112343
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24898349
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24345205
111CDX2_22108803_ChIP-Seq_LS180_Human1.24133895
112BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23681077
113EOMES_21245162_ChIP-Seq_HESCs_Human1.23613486
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22910982
115PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22784388
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22621829
117HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22301323
118SMC1_22415368_ChIP-Seq_MEFs_Mouse1.21619202
119NANOG_19829295_ChIP-Seq_ESCs_Human1.21070234
120SOX2_19829295_ChIP-Seq_ESCs_Human1.21070234
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20658366
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.20284755
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18678850
124ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18488660
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18228941
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18182465
127CRX_20693478_ChIP-Seq_RETINA_Mouse1.17521086
128ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17228268
129* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16761869
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.16724142
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15218819
132JUN_21703547_ChIP-Seq_K562_Human1.14161988
133AR_20517297_ChIP-Seq_VCAP_Human1.12963121
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.12760160
135P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12525752
136MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12260243
137TP53_20018659_ChIP-ChIP_R1E_Mouse1.11687136
138CBX2_27304074_Chip-Seq_ESCs_Mouse1.10869437
139GABP_17652178_ChIP-ChIP_JURKAT_Human1.09100756
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08565514
141* CMYC_18555785_Chip-Seq_ESCs_Mouse1.07544349
142NOTCH1_21737748_ChIP-Seq_TLL_Human1.07076176
143HOXB7_26014856_ChIP-Seq_BT474_Human1.06719352
144NCOR_22424771_ChIP-Seq_293T_Human1.06296302
145P53_22387025_ChIP-Seq_ESCs_Mouse1.06130433
146SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06029959
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05827585
148SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05160832
149GATA3_21878914_ChIP-Seq_MCF-7_Human1.05156198
150ELK3_25401928_ChIP-Seq_HUVEC_Human1.04820527
151TAL1_26923725_Chip-Seq_HPCs_Mouse1.04002354
152STAT3_18555785_Chip-Seq_ESCs_Mouse1.03806633
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03148296
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03116124
155* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.03037090
156TP53_23651856_ChIP-Seq_MEFs_Mouse1.02867717
157AR_21572438_ChIP-Seq_LNCaP_Human1.02696086
158* REST_21632747_ChIP-Seq_MESCs_Mouse1.02479861
159STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02158753
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01398708
161PRDM14_20953172_ChIP-Seq_ESCs_Human1.00919551
162EST1_17652178_ChIP-ChIP_JURKAT_Human1.00465335
163KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99527913
164AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99320691
165TP63_23658742_ChIP-Seq_EP156T_Human0.98637657
166TBX20_22328084_ChIP-Seq_HEART_Mouse0.98289234
167TBX20_22080862_ChIP-Seq_HEART_Mouse0.98289234
168JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97708163
169UBF1/2_26484160_Chip-Seq_HMECs_Human0.97673652
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96196949
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.95121507
172AHR_22903824_ChIP-Seq_MCF-7_Human0.93912145
173PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92586422
174VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91973957
175SMC3_22415368_ChIP-Seq_MEFs_Mouse0.91908728
176JARID2_20064375_ChIP-Seq_MESCs_Mouse0.90597272
177ER_23166858_ChIP-Seq_MCF-7_Human0.90440239
178TP53_22127205_ChIP-Seq_IMR90_Human0.90015996
179P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89984402
180NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87053639
181DROSHA_22980978_ChIP-Seq_HELA_Human0.86830556
182ARNT_22903824_ChIP-Seq_MCF-7_Human0.86377371
183EZH2_27304074_Chip-Seq_ESCs_Mouse0.86331876
184RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86180283
185NFI_21473784_ChIP-Seq_ESCs_Mouse0.85971962
186SA1_22415368_ChIP-Seq_MEFs_Mouse0.85936558
187Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84290687
188* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83565788
189RXR_22108803_ChIP-Seq_LS180_Human0.83133031
190EZH2_27294783_Chip-Seq_ESCs_Mouse0.82724530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen9.75333793
2MP0002876_abnormal_thyroid_physiology8.19986843
3MP0005275_abnormal_skin_tensile5.32341511
4MP0005503_abnormal_tendon_morphology5.14951933
5MP0003279_aneurysm3.87471588
6MP0003705_abnormal_hypodermis_morpholog3.76784918
7MP0001958_emphysema3.74509244
8MP0005623_abnormal_meninges_morphology3.19374167
9MP0009384_cardiac_valve_regurgitation2.99862512
10MP0004272_abnormal_basement_membrane2.77061267
11MP0002160_abnormal_reproductive_system2.75806514
12MP0000631_abnormal_neuroendocrine_gland2.59944706
13MP0000647_abnormal_sebaceous_gland2.39174680
14MP0006054_spinal_hemorrhage2.35135914
15MP0004147_increased_porphyrin_level2.33587214
16MP0005551_abnormal_eye_electrophysiolog2.31724627
17MP0002837_dystrophic_cardiac_calcinosis2.24155524
18MP0001542_abnormal_bone_strength2.21874014
19MP0002295_abnormal_pulmonary_circulatio2.17690478
20MP0003195_calcinosis2.15610090
21MP0000372_irregular_coat_pigmentation2.14240625
22MP0005379_endocrine/exocrine_gland_phen2.11417638
23MP0000013_abnormal_adipose_tissue2.01456624
24MP0000681_abnormal_thyroid_gland1.99999171
25MP0002163_abnormal_gland_morphology1.95281974
26MP0005389_reproductive_system_phenotype1.93831998
27MP0005646_abnormal_pituitary_gland1.92576466
28MP0000920_abnormal_myelination1.92413772
29MP0000427_abnormal_hair_cycle1.91663815
30MP0005508_abnormal_skeleton_morphology1.88404315
31MP0002060_abnormal_skin_morphology1.87706509
32MP0002102_abnormal_ear_morphology1.83332100
33MP0003011_delayed_dark_adaptation1.77779553
34MP0003091_abnormal_cell_migration1.75071521
35MP0002909_abnormal_adrenal_gland1.74536490
36MP0008877_abnormal_DNA_methylation1.68694169
37MP0005023_abnormal_wound_healing1.65334721
38MP0003950_abnormal_plasma_membrane1.64266396
39MP0001299_abnormal_eye_distance/1.64014652
40MP0003566_abnormal_cell_adhesion1.62152769
41MP0000383_abnormal_hair_follicle1.53113543
42MP0002127_abnormal_cardiovascular_syste1.52431606
43MP0001243_abnormal_dermal_layer1.49974619
44MP0002108_abnormal_muscle_morphology1.49355000
45MP0005253_abnormal_eye_physiology1.48921365
46MP0006072_abnormal_retinal_apoptosis1.47512914
47MP0010307_abnormal_tumor_latency1.45935270
48MP0009115_abnormal_fat_cell1.43913775
49MP0009250_abnormal_appendicular_skeleto1.42542222
50MP0002896_abnormal_bone_mineralization1.42258830
51MP0009046_muscle_twitch1.41530620
52MP0003787_abnormal_imprinting1.41527171
53MP0001968_abnormal_touch/_nociception1.41033072
54MP0005257_abnormal_intraocular_pressure1.39081208
55MP0001529_abnormal_vocalization1.39035113
56MP0008872_abnormal_physiological_respon1.33899165
57MP0003385_abnormal_body_wall1.32928345
58MP0003718_maternal_effect1.30627724
59MP0005058_abnormal_lysosome_morphology1.30514018
60MP0002098_abnormal_vibrissa_morphology1.29724107
61MP0000569_abnormal_digit_pigmentation1.29154721
62MP0002933_joint_inflammation1.27531111
63MP0001501_abnormal_sleep_pattern1.26025452
64MP0008875_abnormal_xenobiotic_pharmacok1.25157612
65MP0000767_abnormal_smooth_muscle1.25108304
66MP0005171_absent_coat_pigmentation1.24091668
67MP0000751_myopathy1.23843162
68MP0001348_abnormal_lacrimal_gland1.23217549
69MP0002638_abnormal_pupillary_reflex1.22121933
70MP0004782_abnormal_surfactant_physiolog1.21404586
71MP0000733_abnormal_muscle_development1.21041055
72MP0004134_abnormal_chest_morphology1.20827120
73MP0002736_abnormal_nociception_after1.19297324
74MP0003880_abnormal_central_pattern1.19188288
75MP0006276_abnormal_autonomic_nervous1.18911794
76MP0009745_abnormal_behavioral_response1.18901065
77MP0003646_muscle_fatigue1.18851209
78MP0004133_heterotaxia1.18693916
79MP0002272_abnormal_nervous_system1.17457500
80MP0005164_abnormal_response_to1.14327150
81MP0002210_abnormal_sex_determination1.12566250
82MP0006292_abnormal_olfactory_placode1.11002363
83MP0001764_abnormal_homeostasis1.10690862
84MP0004885_abnormal_endolymph1.10635194
85MP0005075_abnormal_melanosome_morpholog1.09816001
86MP0010352_gastrointestinal_tract_polyps1.08212702
87MP0005390_skeleton_phenotype1.06089918
88MP0000534_abnormal_ureter_morphology1.03197097
89MP0002998_abnormal_bone_remodeling1.03137510
90MP0003698_abnormal_male_reproductive1.02677614
91MP0001881_abnormal_mammary_gland1.01947108
92MP0003300_gastrointestinal_ulcer1.01265386
93MP0005645_abnormal_hypothalamus_physiol1.01108885
94MP0004270_analgesia0.99820993
95MP0000462_abnormal_digestive_system0.99606673
96MP0004185_abnormal_adipocyte_glucose0.99589880
97MP0001919_abnormal_reproductive_system0.98746007
98MP0002115_abnormal_skeleton_extremities0.98659075
99MP0003329_amyloid_beta_deposits0.98504017
100MP0000163_abnormal_cartilage_morphology0.98020414
101MP0004084_abnormal_cardiac_muscle0.97444286
102MP0009780_abnormal_chondrocyte_physiolo0.97330312
103MP0005410_abnormal_fertilization0.96348134
104MP0002970_abnormal_white_adipose0.96139575
105MP0000428_abnormal_craniofacial_morphol0.94359087
106MP0002133_abnormal_respiratory_system0.93962554
107MP0005388_respiratory_system_phenotype0.93962554
108MP0000604_amyloidosis0.92496073
109MP0002877_abnormal_melanocyte_morpholog0.91986200
110MP0005334_abnormal_fat_pad0.91580478
111MP0005084_abnormal_gallbladder_morpholo0.91500193
112MP0003890_abnormal_embryonic-extraembry0.90899791
113MP0004036_abnormal_muscle_relaxation0.90691017
114MP0001984_abnormal_olfaction0.90372762
115MP0001486_abnormal_startle_reflex0.89595731
116MP0004085_abnormal_heartbeat0.88857843
117MP0000003_abnormal_adipose_tissue0.88688154
118MP0009672_abnormal_birth_weight0.87641202
119MP0010678_abnormal_skin_adnexa0.87241876
120MP0006035_abnormal_mitochondrial_morpho0.86982453
121MP0003136_yellow_coat_color0.86963328
122MP0002064_seizures0.86670994
123MP0001177_atelectasis0.86091098
124MP0000747_muscle_weakness0.85296530
125MP0003121_genomic_imprinting0.85125151
126MP0002733_abnormal_thermal_nociception0.84644983
127MP0000230_abnormal_systemic_arterial0.84632326
128MP0003634_abnormal_glial_cell0.83926930
129MP0010329_abnormal_lipoprotein_level0.83751728
130MP0001533_abnormal_skeleton_physiology0.83739090
131MP0003122_maternal_imprinting0.83436278
132MP0005595_abnormal_vascular_smooth0.83258716
133MP0001986_abnormal_taste_sensitivity0.83252218
134MP0000537_abnormal_urethra_morphology0.83156240
135MP0001145_abnormal_male_reproductive0.82898915
136MP0000653_abnormal_sex_gland0.82231635
137MP0003690_abnormal_glial_cell0.81799471
138MP0001661_extended_life_span0.80372861
139MP0004924_abnormal_behavior0.79578262
140MP0005386_behavior/neurological_phenoty0.79578262
141MP0002557_abnormal_social/conspecific_i0.79506490
142MP0001929_abnormal_gametogenesis0.79239981
143MP0004043_abnormal_pH_regulation0.79239488
144MP0008775_abnormal_heart_ventricle0.79118400
145MP0003936_abnormal_reproductive_system0.78463144
146MP0009053_abnormal_anal_canal0.78263085
147MP0005085_abnormal_gallbladder_physiolo0.77355660
148MP0003045_fibrosis0.77242688
149MP0002572_abnormal_emotion/affect_behav0.77183974
150MP0004215_abnormal_myocardial_fiber0.76681530
151MP0004883_abnormal_blood_vessel0.76539924
152MP0009703_decreased_birth_body0.76086010
153MP0004142_abnormal_muscle_tone0.75453545
154MP0005195_abnormal_posterior_eye0.75165519
155MP0003186_abnormal_redox_activity0.75144911
156MP0000639_abnormal_adrenal_gland0.74715655
157MP0002282_abnormal_trachea_morphology0.74063543
158MP0005197_abnormal_uvea_morphology0.73803013
159MP0003937_abnormal_limbs/digits/tail_de0.73509511
160MP0005174_abnormal_tail_pigmentation0.73093499
161MP0001944_abnormal_pancreas_morphology0.72322603
162MP0010094_abnormal_chromosome_stability0.72015353
163MP0002113_abnormal_skeleton_development0.71650024
164MP0002128_abnormal_blood_circulation0.71589342
165MP0001614_abnormal_blood_vessel0.71270096
166MP0002653_abnormal_ependyma_morphology0.71156707
167MP0010030_abnormal_orbit_morphology0.70321757
168MP0002938_white_spotting0.69969046
169MP0001970_abnormal_pain_threshold0.69292720
170MP0001879_abnormal_lymphatic_vessel0.67851249
171MP0003448_altered_tumor_morphology0.67722353
172MP0003942_abnormal_urinary_system0.67618939
173MP0003755_abnormal_palate_morphology0.66248440
174MP0010368_abnormal_lymphatic_system0.65487419
175MP0003795_abnormal_bone_structure0.65226480
176MP0001915_intracranial_hemorrhage0.64333096
177MP0000762_abnormal_tongue_morphology0.64068610
178MP0005193_abnormal_anterior_eye0.63492893
179MP0000759_abnormal_skeletal_muscle0.62987641
180MP0002168_other_aberrant_phenotype0.60916956
181MP0000749_muscle_degeneration0.60634136
182MP0002932_abnormal_joint_morphology0.58161262
183MP0004087_abnormal_muscle_fiber0.57973494
184MP0002254_reproductive_system_inflammat0.56335373
185MP0004233_abnormal_muscle_weight0.55797994
186MP0003283_abnormal_digestive_organ0.54543942
187MP0010234_abnormal_vibrissa_follicle0.54095510
188MP0005375_adipose_tissue_phenotype0.53265126
189MP0000858_altered_metastatic_potential0.53193373
190MP0005369_muscle_phenotype0.52461245
191MP0000627_abnormal_mammary_gland0.52087160
192MP0010771_integument_phenotype0.51619376
193MP0002109_abnormal_limb_morphology0.51337005
194MP0003632_abnormal_nervous_system0.51077019
195MP0010386_abnormal_urinary_bladder0.50709018

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.93659571
2Protrusio acetabuli (HP:0003179)7.56549990
3Aortic dissection (HP:0002647)5.56091114
4Soft skin (HP:0000977)5.12875091
5Peritonitis (HP:0002586)5.02026531
6Aortic aneurysm (HP:0004942)4.77526950
7Congenital stationary night blindness (HP:0007642)4.63522223
8Wormian bones (HP:0002645)4.59617044
9Abnormality of dentin (HP:0010299)4.44672705
10Ankle contracture (HP:0006466)4.39157824
11Atrophic scars (HP:0001075)4.24703665
12Vascular tortuosity (HP:0004948)4.12976569
13Bladder diverticulum (HP:0000015)4.10947474
14Shallow orbits (HP:0000586)3.80301862
15Abnormality of midbrain morphology (HP:0002418)3.73402304
16Molar tooth sign on MRI (HP:0002419)3.73402304
17Pancreatic cysts (HP:0001737)3.71931448
18Blue sclerae (HP:0000592)3.71610174
19Fragile skin (HP:0001030)3.66464706
20Broad metatarsal (HP:0001783)3.61290793
21Arterial tortuosity (HP:0005116)3.59329020
22Cerebral aneurysm (HP:0004944)3.56696930
23Infantile muscular hypotonia (HP:0008947)3.53500554
24Follicular hyperkeratosis (HP:0007502)3.53269385
25Dilatation of the ascending aorta (HP:0005111)3.50044336
26Type 1 muscle fiber predominance (HP:0003803)3.45939729
27Spondylolisthesis (HP:0003302)3.31119385
28Hyperglycinemia (HP:0002154)3.30242724
29Osteolytic defects of the phalanges of the hand (HP:0009771)3.29870539
30Osteolytic defects of the hand bones (HP:0009699)3.29870539
31Abnormal delivery (HP:0001787)3.20176166
32Spinal rigidity (HP:0003306)3.17694879
33True hermaphroditism (HP:0010459)3.17155190
34Vertebral compression fractures (HP:0002953)3.15142402
35Type II lissencephaly (HP:0007260)3.10708527
36Genu recurvatum (HP:0002816)3.09758324
37Abnormality of the renal cortex (HP:0011035)3.07894346
38Oligodactyly (hands) (HP:0001180)3.05459312
39Hyperglycinuria (HP:0003108)3.04444367
40Nephronophthisis (HP:0000090)3.02302369
41Pancreatic fibrosis (HP:0100732)3.02238242
42Hyperextensible skin (HP:0000974)3.02048025
43Chronic hepatic failure (HP:0100626)3.00931573
44Cervical subluxation (HP:0003308)2.97773246
45Medial flaring of the eyebrow (HP:0010747)2.91637340
46Ulnar bowing (HP:0003031)2.86390474
47Hyperventilation (HP:0002883)2.84783854
48Cerebellar dysplasia (HP:0007033)2.80378929
49Neonatal short-limb short stature (HP:0008921)2.78457301
50Abnormal rod and cone electroretinograms (HP:0008323)2.76489607
51Scapular winging (HP:0003691)2.76462486
52Amelogenesis imperfecta (HP:0000705)2.73573949
53Bowel diverticulosis (HP:0005222)2.72782498
54Biconcave vertebral bodies (HP:0004586)2.72769182
55Abnormality of the renal medulla (HP:0100957)2.72144347
56Increased variability in muscle fiber diameter (HP:0003557)2.69805042
57Hypoplasia of the fovea (HP:0007750)2.68641161
58Aplasia/Hypoplasia of the fovea (HP:0008060)2.68641161
59Mitral valve prolapse (HP:0001634)2.68480528
60Decreased central vision (HP:0007663)2.64627726
61Abolished electroretinogram (ERG) (HP:0000550)2.61326542
62Coronal craniosynostosis (HP:0004440)2.61055925
63Abnormality of dental color (HP:0011073)2.59299468
64Bell-shaped thorax (HP:0001591)2.58914278
65Pendular nystagmus (HP:0012043)2.57489853
66Buphthalmos (HP:0000557)2.55379224
67Elbow flexion contracture (HP:0002987)2.55133432
68Attenuation of retinal blood vessels (HP:0007843)2.54788014
69Renal cortical cysts (HP:0000803)2.51937063
70Slender build (HP:0001533)2.47387711
71Progressive inability to walk (HP:0002505)2.40350406
72Gait imbalance (HP:0002141)2.38044861
73Abnormality of skeletal muscle fiber size (HP:0012084)2.36296336
74Aplasia cutis congenita (HP:0001057)2.35649368
75Round ear (HP:0100830)2.34987508
76Inability to walk (HP:0002540)2.34967273
77Lissencephaly (HP:0001339)2.34622923
78Congenital primary aphakia (HP:0007707)2.33475099
79Hypothermia (HP:0002045)2.33474426
80Abnormality of serine family amino acid metabolism (HP:0010894)2.32998365
81Abnormality of glycine metabolism (HP:0010895)2.32998365
82Polydipsia (HP:0001959)2.31330383
83Abnormal drinking behavior (HP:0030082)2.31330383
84Joint laxity (HP:0001388)2.31072524
85Premature skin wrinkling (HP:0100678)2.29969193
86Delayed closure of the anterior fontanelle (HP:0001476)2.29450700
87Aneurysm (HP:0002617)2.29395061
88Widely spaced teeth (HP:0000687)2.28263446
89Femoral bowing (HP:0002980)2.27899553
90Hypomagnesemia (HP:0002917)2.26728852
91Nephrogenic diabetes insipidus (HP:0009806)2.26248244
92Persistence of primary teeth (HP:0006335)2.25570147
93Intestinal atresia (HP:0011100)2.25377684
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23134049
95Degeneration of the lateral corticospinal tracts (HP:0002314)2.23134049
96Wrist flexion contracture (HP:0001239)2.20956120
97Abnormality of the fovea (HP:0000493)2.19609594
98Neurofibrillary tangles (HP:0002185)2.19183451
99Increased connective tissue (HP:0009025)2.18660713
100Increased corneal curvature (HP:0100692)2.18516060
101Keratoconus (HP:0000563)2.18516060
102Broad ribs (HP:0000885)2.17780551
103Decreased circulating renin level (HP:0003351)2.17342454
104Ectopia lentis (HP:0001083)2.16644620
105Nonimmune hydrops fetalis (HP:0001790)2.16515563
106Congenital sensorineural hearing impairment (HP:0008527)2.16243870
107Congenital glaucoma (HP:0001087)2.15493751
108Abnormality of macular pigmentation (HP:0008002)2.14862472
109Overgrowth (HP:0001548)2.14794739
110Wide anterior fontanel (HP:0000260)2.14378738
111Stridor (HP:0010307)2.13530429
112Bulbous nose (HP:0000414)2.12475043
113Tubular atrophy (HP:0000092)2.12425304
114Abnormality of the acetabulum (HP:0003170)2.08221579
115Abnormal biliary tract physiology (HP:0012439)2.08187225
116Bile duct proliferation (HP:0001408)2.08187225
117Abnormality of the peritoneum (HP:0002585)2.06128201
118Osteoarthritis (HP:0002758)2.05493432
119Short hallux (HP:0010109)2.04972281
120Hypoplasia of the iris (HP:0007676)2.02921389
121Narrow nasal bridge (HP:0000446)2.02410430
122Cystic liver disease (HP:0006706)2.00884368
123Acute encephalopathy (HP:0006846)2.00801121
124Tibial bowing (HP:0002982)2.00714473
125Limb dystonia (HP:0002451)2.00599739
126Distal upper limb amyotrophy (HP:0007149)1.99856148
127Upper limb amyotrophy (HP:0009129)1.99856148
128Increased CSF lactate (HP:0002490)1.99549209
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99456760
130Abnormality of the frontal sinuses (HP:0002687)1.98782389
131Abnormality of the labia minora (HP:0012880)1.98520102
132Hyperaldosteronism (HP:0000859)1.97777722
133Bony spicule pigmentary retinopathy (HP:0007737)1.97535984
134Polyuria (HP:0000103)1.95746741
135Coxa vara (HP:0002812)1.95608396
136Mitochondrial inheritance (HP:0001427)1.94437807
137Calcaneovalgus deformity (HP:0001848)1.94268266
138Mitral regurgitation (HP:0001653)1.93424024
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.93039331
140Optic nerve hypoplasia (HP:0000609)1.91987546
141Aplasia/Hypoplasia of the spleen (HP:0010451)1.91765185
142Delayed cranial suture closure (HP:0000270)1.90961322
143Oligodactyly (HP:0012165)1.90457086
144Mildly elevated creatine phosphokinase (HP:0008180)1.90033043
1453-Methylglutaconic aciduria (HP:0003535)1.89916352
146Muscle fiber splitting (HP:0003555)1.89823151
147Absent speech (HP:0001344)1.89523533
148Genital tract atresia (HP:0001827)1.89036491
149Breech presentation (HP:0001623)1.88553187
150Acute necrotizing encephalopathy (HP:0006965)1.88331119
151Bowing of the arm (HP:0006488)1.86936307
152Bowed forearm bones (HP:0003956)1.86936307
153Retinal dysplasia (HP:0007973)1.86807477
154Vaginal atresia (HP:0000148)1.86573206
155Venous abnormality (HP:0002624)1.86536654
156Hyporeflexia of lower limbs (HP:0002600)1.86153319
157Albinism (HP:0001022)1.85739420
158Knee flexion contracture (HP:0006380)1.85385259
159Aplasia/Hypoplasia of the hallux (HP:0008362)1.85229794
160Woolly hair (HP:0002224)1.82964025
161Pterygium (HP:0001059)1.82605309
162Absent frontal sinuses (HP:0002688)1.80474524
163Radial bowing (HP:0002986)1.80200573
164Methylmalonic acidemia (HP:0002912)1.77989100
165Astigmatism (HP:0000483)1.77707842
166Skin nodule (HP:0200036)1.77560995
167Broad-based gait (HP:0002136)1.77080116
168Progressive macrocephaly (HP:0004481)1.76478709
169Inguinal hernia (HP:0000023)1.76363056
170Hepatocellular necrosis (HP:0001404)1.76068885
171Abnormal sex determination (HP:0012244)1.75936841
172Sex reversal (HP:0012245)1.75936841
173Pachygyria (HP:0001302)1.75647717
174Hemiparesis (HP:0001269)1.75214621
175Renal salt wasting (HP:0000127)1.74291938
176Turricephaly (HP:0000262)1.74102986
177Chorioretinal atrophy (HP:0000533)1.73631584
178Widely patent fontanelles and sutures (HP:0004492)1.73593161
179Platyspondyly (HP:0000926)1.72957411
180Tarsal synostosis (HP:0008368)1.72475425
181Febrile seizures (HP:0002373)1.72361423
182Generalized amyotrophy (HP:0003700)1.72319430
183Hepatic necrosis (HP:0002605)1.72206467
184Aplasia involving bones of the upper limbs (HP:0009823)1.71696048
185Aplasia of the phalanges of the hand (HP:0009802)1.71696048
186Aplasia involving bones of the extremities (HP:0009825)1.71696048
187Deformed tarsal bones (HP:0008119)1.70344559
188Deviation of the hallux (HP:0010051)1.70326448
189Impulsivity (HP:0100710)1.69986967
190Cerebral inclusion bodies (HP:0100314)1.69934510
191Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69742693
192Occipital encephalocele (HP:0002085)1.68985240
193Male pseudohermaphroditism (HP:0000037)1.68404590
194Stomach cancer (HP:0012126)1.68217854
195Sclerocornea (HP:0000647)1.65654578
196Tachypnea (HP:0002789)1.65183044

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.96817332
2DDR23.79987793
3MAP4K23.75768566
4AKT33.36351376
5TTN3.27467113
6OXSR13.13614299
7MET3.07520589
8WNK33.01290184
9LIMK12.77282237
10TRPM72.64979013
11WEE12.64329468
12PDGFRA2.54978473
13BRSK22.44848301
14TESK22.32584761
15TNIK2.31209492
16TAOK32.28760343
17GRK12.22392151
18TRIM282.19072882
19MAPK132.19035284
20PAK32.17683128
21TLK12.13416672
22EPHB12.05981368
23ICK1.99312640
24FRK1.97120549
25PINK11.94701928
26ADRBK21.94354941
27PAK21.93542728
28NME11.91671315
29LATS11.91563547
30ZAK1.85427585
31FGFR21.81674652
32LATS21.80380613
33CASK1.75730362
34NTRK11.71190220
35TRIB31.70661314
36MAP3K41.62003626
37WNK11.56782566
38MYLK1.56129461
39TESK11.55951159
40BMPR1B1.53810245
41BCR1.51457080
42INSRR1.50842326
43PIK3CA1.41945725
44CLK11.38188409
45MAP2K61.37508114
46ROCK21.37010354
47ACVR1B1.35425045
48NEK61.35198475
49PDGFRB1.33663538
50EIF2AK31.31751246
51NEK11.31561422
52PTK21.30024918
53CDK191.29592798
54EPHB21.26499998
55ERN11.26389251
56BMX1.24670319
57PIK3CG1.24448247
58EPHA31.23562679
59PDK21.22420161
60PNCK1.21677613
61PAK61.17936500
62DMPK1.17856651
63PLK31.17096607
64GSK3A1.16190585
65TAOK21.15075560
66PKN21.12953545
67STK31.12202625
68ROCK11.11168668
69CSNK1A1L1.09743135
70ARAF1.09089757
71FER1.08899958
72MOS1.08619670
73LRRK21.00084344
74CSNK1G30.98231444
75TGFBR20.94408162
76MKNK20.93871728
77PHKG20.93266967
78PHKG10.93266967
79DYRK20.93250616
80MARK10.91561741
81PLK40.89796419
82MAPKAPK50.89157275
83TGFBR10.88484923
84CSNK1G10.87938437
85PTK2B0.87272838
86CDK140.87177672
87RET0.86693881
88MAPKAPK30.86203316
89CDK150.86059154
90WNK40.85332508
91PRKCG0.84024007
92FGFR10.82821632
93DAPK20.81791891
94PKN10.80704519
95SIK10.79699425
96MST40.78592008
97DAPK30.77570455
98CDK180.77409128
99ABL20.75720807
100VRK10.74018469
101PAK10.73424621
102CDK11A0.71607504
103NUAK10.71587301
104PLK20.71235098
105INSR0.70840717
106PRKCI0.70828336
107MUSK0.70770363
108PBK0.70051769
109PDPK10.68661298
110NME20.66500414
111PRKD10.66293430
112CSNK1G20.65587093
113ADRBK10.65453874
114TYRO30.64634311
115FGR0.64153372
116CSNK1A10.63316669
117NLK0.62852252
118KSR20.61633883
119CAMK2D0.61042395
120CAMK10.60438925
121PIM20.58499275
122MAP3K50.57532757
123MAP2K10.56905334
124KIT0.56821044
125CAMK2B0.56543345
126MAP3K20.55901190
127PAK40.55589464
128ERBB40.53821292
129PRKCH0.53376363
130STK100.52597196
131PRKCQ0.52499571
132PIM10.51294958
133PTK60.51222837
134MAP2K70.50597135
135BRSK10.50499722
136FYN0.48239786
137VRK20.48127707
138ERBB30.47218800
139PRKCE0.46920863
140BCKDK0.45654910
141SRC0.45149558
142STK38L0.45023104
143PRPF4B0.44739038
144ABL10.43909173
145MAP3K70.43122644
146SGK20.42756966
147PRKAA20.42384587
148ITK0.42200234
149PRKCZ0.42190493
150CAMK2A0.40554478
151CSF1R0.40521726
152RAF10.39991498
153CAMK2G0.39902446
154SIK30.39738835
155MTOR0.39161713
156MAP3K120.37999729
157MARK30.37560800
158PRKAA10.37410682
159JAK10.37213774
160TXK0.36424095
161CAMKK20.36036348
162CDK50.35844918
163PRKACA0.34530005
164MINK10.33619756
165PLK10.33287061
166PRKACB0.31443699
167MKNK10.30994464
168MATK0.30773238
169IKBKB0.29977182
170CSNK1D0.29749214
171PRKCA0.27642515
172CSNK1E0.27488452
173GRK50.25772039

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.56425877
2Phototransduction_Homo sapiens_hsa047443.02776609
3Focal adhesion_Homo sapiens_hsa045103.01299866
4Malaria_Homo sapiens_hsa051442.59473452
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.37677522
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.28983959
7Butanoate metabolism_Homo sapiens_hsa006502.25378318
8Linoleic acid metabolism_Homo sapiens_hsa005912.14680168
9Selenocompound metabolism_Homo sapiens_hsa004502.09930933
10Proteoglycans in cancer_Homo sapiens_hsa052052.07026040
11Protein digestion and absorption_Homo sapiens_hsa049742.04844812
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.00647415
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99500874
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97462936
15Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.96802773
16Dilated cardiomyopathy_Homo sapiens_hsa054141.89472598
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.89292104
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87269642
19Amoebiasis_Homo sapiens_hsa051461.86281546
20Lysosome_Homo sapiens_hsa041421.85719106
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.84293887
22Sulfur metabolism_Homo sapiens_hsa009201.82561959
23Phagosome_Homo sapiens_hsa041451.77379170
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75911011
25Basal transcription factors_Homo sapiens_hsa030221.71165089
26Autoimmune thyroid disease_Homo sapiens_hsa053201.71146206
27* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.61694290
28Propanoate metabolism_Homo sapiens_hsa006401.61339095
29Axon guidance_Homo sapiens_hsa043601.61275263
30Oxidative phosphorylation_Homo sapiens_hsa001901.60096583
31Sphingolipid metabolism_Homo sapiens_hsa006001.56647835
32Nicotine addiction_Homo sapiens_hsa050331.56143567
33Regulation of actin cytoskeleton_Homo sapiens_hsa048101.54493254
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.52747795
35Homologous recombination_Homo sapiens_hsa034401.51144313
36Bladder cancer_Homo sapiens_hsa052191.47460392
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44818846
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44184674
39Fanconi anemia pathway_Homo sapiens_hsa034601.42151352
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41467786
41Vibrio cholerae infection_Homo sapiens_hsa051101.39776982
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39558732
43TGF-beta signaling pathway_Homo sapiens_hsa043501.39165334
44Tight junction_Homo sapiens_hsa045301.39101824
45Protein export_Homo sapiens_hsa030601.36126185
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.35922748
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.30264903
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30200334
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29450614
50Rheumatoid arthritis_Homo sapiens_hsa053231.28904642
51Tryptophan metabolism_Homo sapiens_hsa003801.28842025
52Renal cell carcinoma_Homo sapiens_hsa052111.27652183
53Regulation of autophagy_Homo sapiens_hsa041401.26683320
54Small cell lung cancer_Homo sapiens_hsa052221.26099545
55Collecting duct acid secretion_Homo sapiens_hsa049661.24253725
56Steroid biosynthesis_Homo sapiens_hsa001001.22037953
57Shigellosis_Homo sapiens_hsa051311.20690485
58MicroRNAs in cancer_Homo sapiens_hsa052061.18414897
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16982436
60Peroxisome_Homo sapiens_hsa041461.14353043
61One carbon pool by folate_Homo sapiens_hsa006701.13056607
62Hippo signaling pathway_Homo sapiens_hsa043901.12911594
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.07675880
64Olfactory transduction_Homo sapiens_hsa047401.06795105
65Taste transduction_Homo sapiens_hsa047421.06321069
66Endocytosis_Homo sapiens_hsa041441.05750630
67Primary bile acid biosynthesis_Homo sapiens_hsa001201.01915315
68Arginine and proline metabolism_Homo sapiens_hsa003301.01540253
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99357631
70Glutathione metabolism_Homo sapiens_hsa004800.98938405
71Fatty acid elongation_Homo sapiens_hsa000620.98555476
72Melanoma_Homo sapiens_hsa052180.98521304
73Parkinsons disease_Homo sapiens_hsa050120.97400503
74Non-homologous end-joining_Homo sapiens_hsa034500.93219211
75Ether lipid metabolism_Homo sapiens_hsa005650.92944181
76ABC transporters_Homo sapiens_hsa020100.92157726
77Arachidonic acid metabolism_Homo sapiens_hsa005900.91974954
78Chronic myeloid leukemia_Homo sapiens_hsa052200.89930125
79Salmonella infection_Homo sapiens_hsa051320.88360565
80* Ras signaling pathway_Homo sapiens_hsa040140.87634291
81Prostate cancer_Homo sapiens_hsa052150.86504128
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86159926
83Adherens junction_Homo sapiens_hsa045200.84852967
84Platelet activation_Homo sapiens_hsa046110.84759448
85GnRH signaling pathway_Homo sapiens_hsa049120.84645377
86Thyroid hormone synthesis_Homo sapiens_hsa049180.84204086
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83823404
88Insulin secretion_Homo sapiens_hsa049110.83653576
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.83400478
90RNA degradation_Homo sapiens_hsa030180.82773735
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82542549
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81840398
93Chemical carcinogenesis_Homo sapiens_hsa052040.81494138
94RNA polymerase_Homo sapiens_hsa030200.81436534
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80489681
96beta-Alanine metabolism_Homo sapiens_hsa004100.80132709
97* Rap1 signaling pathway_Homo sapiens_hsa040150.79712509
98Prolactin signaling pathway_Homo sapiens_hsa049170.79589386
99Glioma_Homo sapiens_hsa052140.77929740
100Circadian rhythm_Homo sapiens_hsa047100.75544679
101Other glycan degradation_Homo sapiens_hsa005110.75253450
102Morphine addiction_Homo sapiens_hsa050320.73641425
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73039577
104Prion diseases_Homo sapiens_hsa050200.72304313
105Complement and coagulation cascades_Homo sapiens_hsa046100.71829578
106Metabolic pathways_Homo sapiens_hsa011000.70781728
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70178690
108Pathways in cancer_Homo sapiens_hsa052000.69254882
109Fat digestion and absorption_Homo sapiens_hsa049750.68492442
110Glycerolipid metabolism_Homo sapiens_hsa005610.68387756
111Retinol metabolism_Homo sapiens_hsa008300.67652277
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67470329
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67442385
114Serotonergic synapse_Homo sapiens_hsa047260.64310682
115Circadian entrainment_Homo sapiens_hsa047130.62358003
116Mineral absorption_Homo sapiens_hsa049780.62276707
117Ovarian steroidogenesis_Homo sapiens_hsa049130.62053654
118Gap junction_Homo sapiens_hsa045400.61964655
119Hedgehog signaling pathway_Homo sapiens_hsa043400.61506218
120Pancreatic cancer_Homo sapiens_hsa052120.61436557
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60757539
122ErbB signaling pathway_Homo sapiens_hsa040120.60611139
123Salivary secretion_Homo sapiens_hsa049700.59597265
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.58883367
125Fatty acid metabolism_Homo sapiens_hsa012120.58574905
126GABAergic synapse_Homo sapiens_hsa047270.57122031
127Basal cell carcinoma_Homo sapiens_hsa052170.57062003
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56764396
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56280172
130Viral myocarditis_Homo sapiens_hsa054160.56012226
131Cardiac muscle contraction_Homo sapiens_hsa042600.55806079
132Caffeine metabolism_Homo sapiens_hsa002320.55308341
133N-Glycan biosynthesis_Homo sapiens_hsa005100.55208997
134Huntingtons disease_Homo sapiens_hsa050160.54411188
135Wnt signaling pathway_Homo sapiens_hsa043100.54171774
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54103650
137Glutamatergic synapse_Homo sapiens_hsa047240.51807607
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51655384
139Oocyte meiosis_Homo sapiens_hsa041140.50666959
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50539561
141Alzheimers disease_Homo sapiens_hsa050100.50521658
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50460207
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.48625175
144alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48199628
145Purine metabolism_Homo sapiens_hsa002300.47990035
146Pertussis_Homo sapiens_hsa051330.46891553
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45714913
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45559863
149Calcium signaling pathway_Homo sapiens_hsa040200.43355674
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42230362
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42155950
152Toxoplasmosis_Homo sapiens_hsa051450.41624726
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.41340247
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40922572
155Dopaminergic synapse_Homo sapiens_hsa047280.39741368
156Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39706210
157Fatty acid degradation_Homo sapiens_hsa000710.38971175
158Renin-angiotensin system_Homo sapiens_hsa046140.38392711
159Cocaine addiction_Homo sapiens_hsa050300.37895905
160Apoptosis_Homo sapiens_hsa042100.36191468
161Steroid hormone biosynthesis_Homo sapiens_hsa001400.35891301
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33701910
163p53 signaling pathway_Homo sapiens_hsa041150.33426235
164Nitrogen metabolism_Homo sapiens_hsa009100.33061681
165Histidine metabolism_Homo sapiens_hsa003400.32741791
166TNF signaling pathway_Homo sapiens_hsa046680.30777156
167Choline metabolism in cancer_Homo sapiens_hsa052310.30390513
168VEGF signaling pathway_Homo sapiens_hsa043700.30218305
169PPAR signaling pathway_Homo sapiens_hsa033200.29564455
170Tuberculosis_Homo sapiens_hsa051520.27958133

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