ANGPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted glycoprotein that belongs to the angiopoietin family. Members of this family play important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme and inhibits endothelial permeability. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)7.73148951
2ribosomal small subunit assembly (GO:0000028)7.58173894
3platelet dense granule organization (GO:0060155)6.24075246
4endothelium development (GO:0003158)6.21481980
5positive regulation of vasculogenesis (GO:2001214)5.74549624
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.50677183
7viral transcription (GO:0019083)5.31951170
8megakaryocyte development (GO:0035855)5.31342014
9negative regulation of erythrocyte differentiation (GO:0045647)5.20167830
10translational termination (GO:0006415)5.12227693
11aggressive behavior (GO:0002118)5.04863858
12antigen processing and presentation via MHC class Ib (GO:0002475)4.89686194
13polyketide metabolic process (GO:0030638)4.68925665
14doxorubicin metabolic process (GO:0044598)4.68925665
15daunorubicin metabolic process (GO:0044597)4.68925665
16DNA deamination (GO:0045006)4.66145103
17endosome to melanosome transport (GO:0035646)4.62587784
18endosome to pigment granule transport (GO:0043485)4.62587784
19translational elongation (GO:0006414)4.56969534
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.47347892
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.47347892
22ribosomal small subunit biogenesis (GO:0042274)4.46881752
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.39438706
24cotranslational protein targeting to membrane (GO:0006613)4.28539793
25response to interferon-beta (GO:0035456)4.26794055
26regulation of penile erection (GO:0060405)4.25543325
27protein targeting to ER (GO:0045047)4.25172590
28response to interferon-alpha (GO:0035455)4.22403933
29maturation of SSU-rRNA (GO:0030490)4.21847591
30negative regulation of nitric oxide biosynthetic process (GO:0045019)4.21551314
31lymphoid progenitor cell differentiation (GO:0002320)4.17604827
32secretory granule organization (GO:0033363)4.15425792
33valine metabolic process (GO:0006573)4.14359916
34regulation of skeletal muscle contraction (GO:0014819)4.13752010
35extracellular fibril organization (GO:0043206)4.10359192
36protein localization to endoplasmic reticulum (GO:0070972)4.06789678
37mature B cell differentiation involved in immune response (GO:0002313)4.06717880
38establishment of protein localization to endoplasmic reticulum (GO:0072599)4.05995596
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.03952673
40regulation of female receptivity (GO:0045924)3.92930009
41viral life cycle (GO:0019058)3.91837468
42negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.89368134
43regulation of vasculogenesis (GO:2001212)3.86002845
44angiogenesis involved in wound healing (GO:0060055)3.84589001
45positive regulation of B cell differentiation (GO:0045579)3.82775553
46fucose catabolic process (GO:0019317)3.79885158
47L-fucose metabolic process (GO:0042354)3.79885158
48L-fucose catabolic process (GO:0042355)3.79885158
49blood vessel maturation (GO:0001955)3.78381273
50protein neddylation (GO:0045116)3.75975552
51cellular protein complex disassembly (GO:0043624)3.71566103
52seminiferous tubule development (GO:0072520)3.69063088
53necroptotic process (GO:0070266)3.67565381
54epithelial cell differentiation involved in kidney development (GO:0035850)3.65154376
55telomere maintenance via semi-conservative replication (GO:0032201)3.64582738
56response to vitamin E (GO:0033197)3.62872394
57translational initiation (GO:0006413)3.60717439
58regulation of platelet aggregation (GO:0090330)3.54548703
59antigen processing and presentation of endogenous antigen (GO:0019883)3.52583153
60positive regulation of gamma-delta T cell activation (GO:0046645)3.52066538
61autophagic vacuole fusion (GO:0000046)3.50692672
62embryonic hemopoiesis (GO:0035162)3.46740578
63regulation of Golgi to plasma membrane protein transport (GO:0042996)3.44765460
64regulation of platelet activation (GO:0010543)3.43089339
65cell differentiation involved in metanephros development (GO:0072202)3.41233797
66regulation of integrin activation (GO:0033623)3.40941497
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39372748
68protein complex disassembly (GO:0043241)3.38730561
69female mating behavior (GO:0060180)3.37330198
70DNA strand elongation involved in DNA replication (GO:0006271)3.37061278
71tyrosine phosphorylation of STAT protein (GO:0007260)3.36129314
72lymph node development (GO:0048535)3.35224294
73T cell homeostasis (GO:0043029)3.34102860
74platelet aggregation (GO:0070527)3.33801489
75DNA strand elongation (GO:0022616)3.31206476
76nuclear-transcribed mRNA catabolic process (GO:0000956)3.30798378
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30079003
78fibril organization (GO:0097435)3.29333008
79positive regulation of transforming growth factor beta production (GO:0071636)3.29098421
80IMP metabolic process (GO:0046040)3.24707214
81myeloid cell development (GO:0061515)3.23830636
82telomere maintenance via recombination (GO:0000722)3.23156129
83parental behavior (GO:0060746)3.22405639
84regulation of erythrocyte differentiation (GO:0045646)3.20050874
85hematopoietic stem cell proliferation (GO:0071425)3.19936223
86organelle membrane fusion (GO:0090174)3.19774300
87mRNA catabolic process (GO:0006402)3.19124686
88purine-containing compound salvage (GO:0043101)3.18810570
89sleep (GO:0030431)3.16608200
90macromolecular complex disassembly (GO:0032984)3.16134276
91cGMP biosynthetic process (GO:0006182)3.15020107
92IMP biosynthetic process (GO:0006188)3.14623529
93maternal behavior (GO:0042711)3.12293338
94regulation of T-helper 1 cell differentiation (GO:0045625)3.08184749
95Peyers patch development (GO:0048541)3.06921827
96mucosal-associated lymphoid tissue development (GO:0048537)3.06921827
97pseudouridine synthesis (GO:0001522)3.02503982
98RNA catabolic process (GO:0006401)3.01464869
99growth hormone receptor signaling pathway (GO:0060396)2.99478618
100aminoglycoside antibiotic metabolic process (GO:0030647)2.99114029
101DNA unwinding involved in DNA replication (GO:0006268)2.98476147
102ribosomal large subunit biogenesis (GO:0042273)2.97584979
103relaxation of smooth muscle (GO:0044557)2.96824316
104mature B cell differentiation (GO:0002335)2.95442087
105DNA replication initiation (GO:0006270)2.95290896
106adenosine metabolic process (GO:0046085)2.90773502
107respiratory chain complex IV assembly (GO:0008535)2.90049452
108mast cell activation (GO:0045576)2.89633877
109programmed necrotic cell death (GO:0097300)2.89330384
110positive regulation of granulocyte differentiation (GO:0030854)2.88734705
111regulation of integrin-mediated signaling pathway (GO:2001044)2.88594027
112fatty acid transmembrane transport (GO:1902001)2.88247932
113phospholipid scrambling (GO:0017121)2.87738015
114muscle filament sliding (GO:0030049)2.87661021
115actin-myosin filament sliding (GO:0033275)2.87661021
116toxin transport (GO:1901998)2.87501549
117mitotic recombination (GO:0006312)2.84632865
118positive regulation of natural killer cell differentiation (GO:0032825)2.84280331
119cardiolipin metabolic process (GO:0032048)2.83075646
120dopamine transport (GO:0015872)2.82513373
121positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81703379
122purine nucleotide salvage (GO:0032261)2.81012994
123regulation of natural killer cell differentiation (GO:0032823)2.80476074
124phagocytosis, recognition (GO:0006910)2.80071421
125thrombin receptor signaling pathway (GO:0070493)2.79191980
126ribonucleoprotein complex biogenesis (GO:0022613)2.77861630
127regulation of necroptotic process (GO:0060544)2.77524437
128actin-mediated cell contraction (GO:0070252)2.76307800
129response to protozoan (GO:0001562)2.75479039
130cytokine production involved in immune response (GO:0002367)2.75434797
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.75317053
132negative regulation of calcium ion transmembrane transport (GO:1903170)2.75317053
133defense response to protozoan (GO:0042832)2.73980863
134regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.73488680
135protein targeting to membrane (GO:0006612)2.73421756
136cellular response to growth hormone stimulus (GO:0071378)2.73110431
137negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72888843
138negative regulation of T-helper cell differentiation (GO:0045623)2.72888843
139positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72764151
140cellular response to thyroid hormone stimulus (GO:0097067)2.69762446
141mast cell degranulation (GO:0043303)2.68256838
142mast cell activation involved in immune response (GO:0002279)2.68256838
143negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.67512422
144negative regulation of viral genome replication (GO:0045071)2.66901647
145blood coagulation, intrinsic pathway (GO:0007597)2.66283030
146negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65876858
147telomere maintenance via telomere lengthening (GO:0010833)2.64823382
148positive regulation of Rho protein signal transduction (GO:0035025)2.63918328
149regulation of T cell mediated cytotoxicity (GO:0001914)2.63277539
150negative regulation of norepinephrine secretion (GO:0010700)2.62077846
151CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.62064347
152negative regulation of phagocytosis (GO:0050765)2.61984627
153regulation of necrotic cell death (GO:0010939)2.61930724
154positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61826411
155negative regulation of nitric-oxide synthase activity (GO:0051001)2.61411335
156negative regulation of smooth muscle cell migration (GO:0014912)2.61237720
157UV protection (GO:0009650)2.61135094
158nitric oxide mediated signal transduction (GO:0007263)2.60877669
159negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.60049414
160branched-chain amino acid metabolic process (GO:0009081)2.59774945
161protein heterotrimerization (GO:0070208)2.59560347
162RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59355102
163execution phase of apoptosis (GO:0097194)2.59333326
164B cell activation involved in immune response (GO:0002312)2.59267470
165metallo-sulfur cluster assembly (GO:0031163)2.59213713
166negative regulation of muscle contraction (GO:0045932)2.58779075
167negative regulation of thymocyte apoptotic process (GO:0070244)2.57170453
168rRNA modification (GO:0000154)2.57026251
169negative regulation of protein localization to cell surface (GO:2000009)2.56172432
170interkinetic nuclear migration (GO:0022027)2.55819889
171Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54732623
172relaxation of muscle (GO:0090075)2.53319696
173ubiquinone biosynthetic process (GO:0006744)2.52140511
174pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50143331
175granulocyte differentiation (GO:0030851)2.49886819
176negative regulation of appetite (GO:0032099)2.49775551
177negative regulation of response to food (GO:0032096)2.49775551
178sequestering of extracellular ligand from receptor (GO:0035581)2.46733378
179positive regulation of odontogenesis (GO:0042482)2.46332798
180monoamine transport (GO:0015844)2.46159364
181leukocyte tethering or rolling (GO:0050901)2.43954054
182positive regulation of glomerulus development (GO:0090193)2.43905492
183hematopoietic stem cell differentiation (GO:0060218)2.43522785
184glomerular filtration (GO:0003094)2.42391865
185cell wall macromolecule catabolic process (GO:0016998)2.40664216
186positive regulation of catecholamine secretion (GO:0033605)2.37775263
187piRNA metabolic process (GO:0034587)2.36838557
188ketone biosynthetic process (GO:0042181)2.36142546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.35823339
2E2F7_22180533_ChIP-Seq_HELA_Human5.21094937
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.58731052
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.35031145
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31625775
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.25141396
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.23715743
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.18969972
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.15846574
10TAL1_20887958_ChIP-Seq_HPC-7_Mouse3.14044412
11ELF1_17652178_ChIP-ChIP_JURKAT_Human3.00238613
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.82421950
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77416209
14GATA1_22025678_ChIP-Seq_K562_Human2.70570765
15FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.69525871
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61298202
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.59029288
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.55836338
19* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.42738292
20ERG_20887958_ChIP-Seq_HPC-7_Mouse2.42592973
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41940521
22HOXB4_20404135_ChIP-ChIP_EML_Mouse2.38414826
23SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.38145663
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33722702
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.32041571
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20114667
27* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.19383889
28SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.19371191
29VDR_22108803_ChIP-Seq_LS180_Human2.17020490
30SPI1_23547873_ChIP-Seq_NB4_Human2.15670187
31MYC_22102868_ChIP-Seq_BL_Human2.14416936
32* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.11580684
33* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.11580684
34MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09696843
35GATA1_19941826_ChIP-Seq_K562_Human2.05024058
36* FUS_26573619_Chip-Seq_HEK293_Human2.03848847
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01615767
38* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.00280198
39ZNF274_21170338_ChIP-Seq_K562_Hela1.99937615
40* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99612863
41GBX2_23144817_ChIP-Seq_PC3_Human1.99167737
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.97857598
43VDR_23849224_ChIP-Seq_CD4+_Human1.96221720
44IGF1R_20145208_ChIP-Seq_DFB_Human1.94728113
45FOXP3_21729870_ChIP-Seq_TREG_Human1.94268395
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.90916546
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.90806056
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89717247
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89702541
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89374292
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89290346
52VDR_21846776_ChIP-Seq_THP-1_Human1.88479535
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.86603786
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.84203277
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81463636
56EWS_26573619_Chip-Seq_HEK293_Human1.80432419
57GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.78818327
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.74868938
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74402939
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72904176
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72510084
62BRD4_25478319_ChIP-Seq_HGPS_Human1.69894194
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69553289
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.64452590
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64067990
66* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63539829
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63270793
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.62739431
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.61622106
70* GATA2_19941826_ChIP-Seq_K562_Human1.60735741
71CIITA_25753668_ChIP-Seq_RAJI_Human1.60303119
72NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60237635
73XRN2_22483619_ChIP-Seq_HELA_Human1.59913848
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54103051
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52746594
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52477759
77VDR_24763502_ChIP-Seq_THP-1_Human1.52231463
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51864534
79MYB_26560356_Chip-Seq_TH2_Human1.51390199
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.49379654
81ELK1_19687146_ChIP-ChIP_HELA_Human1.48987228
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47949407
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46796393
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43849543
85MYB_26560356_Chip-Seq_TH1_Human1.42304402
86Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41972641
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40858634
88TAF15_26573619_Chip-Seq_HEK293_Human1.40686658
89CJUN_26792858_Chip-Seq_BT549_Human1.39205842
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39038946
91* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38542713
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.36884020
93ER_23166858_ChIP-Seq_MCF-7_Human1.36524911
94TCF7_22412390_ChIP-Seq_EML_Mouse1.36426482
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34389046
96MAF_26560356_Chip-Seq_TH1_Human1.33074526
97GABP_19822575_ChIP-Seq_HepG2_Human1.32932522
98AR_20517297_ChIP-Seq_VCAP_Human1.32873518
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.31006261
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29729539
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.28868479
102UTX_26944678_Chip-Seq_JUKART_Human1.28545740
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.27916489
104* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27220502
105* ERG_20517297_ChIP-Seq_VCAP_Human1.27026640
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.25686162
107* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23064221
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22411997
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.21035659
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.20827531
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20267971
112TTF2_22483619_ChIP-Seq_HELA_Human1.20106049
113* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17631019
114ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17308916
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17132116
116RUNX_20019798_ChIP-Seq_JUKART_Human1.15733662
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14819947
118* SOX2_19829295_ChIP-Seq_ESCs_Human1.13478662
119* NANOG_19829295_ChIP-Seq_ESCs_Human1.13478662
120SALL4_22934838_ChIP-ChIP_CD34+_Human1.13308645
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12494455
122SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12442403
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.11890417
124IRF8_21731497_ChIP-ChIP_J774_Mouse1.10150058
125CRX_20693478_ChIP-Seq_RETINA_Mouse1.10082654
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10028268
127* P300_19829295_ChIP-Seq_ESCs_Human1.09631080
128DCP1A_22483619_ChIP-Seq_HELA_Human1.09265913
129* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09264527
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09169970
131* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.08713165
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07931318
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07669378
134* PIAS1_25552417_ChIP-Seq_VCAP_Human1.06860345
135JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06752232
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06661905
137PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06334229
138GATA3_26560356_Chip-Seq_TH2_Human1.05629864
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03666412
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02790916
141THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01901577
142NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01562343
143FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00182383
144* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99276352
145EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98888911
146* SA1_22415368_ChIP-Seq_MEFs_Mouse0.95157866
147CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95146375
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94570048
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94227871
150P53_22387025_ChIP-Seq_ESCs_Mouse0.94216183
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93539870
152CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91723220
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90661018
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90308312
155CBP_20019798_ChIP-Seq_JUKART_Human0.90308312
156SPI1_23127762_ChIP-Seq_K562_Human0.90101917
157CDX2_22108803_ChIP-Seq_LS180_Human0.89751842
158OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89448595
159* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89127953
160YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88891109
161TP53_22573176_ChIP-Seq_HFKS_Human0.88592736
162JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88585769
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87494421
164NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87062623
165PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86623846
166E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86600304
167SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.86195719
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85296294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.91348134
2MP0004808_abnormal_hematopoietic_stem4.19382075
3MP0008438_abnormal_cutaneous_collagen4.08542793
4MP0004147_increased_porphyrin_level3.27786856
5MP0000465_gastrointestinal_hemorrhage3.17855992
6MP0001545_abnormal_hematopoietic_system3.14691804
7MP0005397_hematopoietic_system_phenotyp3.14691804
8MP0005503_abnormal_tendon_morphology3.12493782
9MP0005174_abnormal_tail_pigmentation3.06599209
10MP0005464_abnormal_platelet_physiology3.01313005
11MP0006054_spinal_hemorrhage2.74069166
12MP0005670_abnormal_white_adipose2.71205049
13MP0005075_abnormal_melanosome_morpholog2.68163808
14MP0005275_abnormal_skin_tensile2.66943418
15MP0001835_abnormal_antigen_presentation2.64122346
16MP0000013_abnormal_adipose_tissue2.37678281
17MP0000685_abnormal_immune_system2.27372298
18MP0002095_abnormal_skin_pigmentation2.27188099
19MP0009785_altered_susceptibility_to2.22781926
20MP0004036_abnormal_muscle_relaxation2.19372636
21MP0003724_increased_susceptibility_to2.18241468
22MP0009278_abnormal_bone_marrow2.17189216
23MP0000490_abnormal_crypts_of2.13314434
24MP0004145_abnormal_muscle_electrophysio2.10269946
25MP0003763_abnormal_thymus_physiology2.08727881
26MP0002398_abnormal_bone_marrow2.07548011
27MP0005671_abnormal_response_to2.06116773
28MP0009379_abnormal_foot_pigmentation2.05882457
29MP0003943_abnormal_hepatobiliary_system1.93547448
30MP0009697_abnormal_copulation1.92759292
31MP0008007_abnormal_cellular_replicative1.91348542
32MP0000230_abnormal_systemic_arterial1.90483305
33MP0008004_abnormal_stomach_pH1.88902834
34MP0005646_abnormal_pituitary_gland1.88109998
35MP0002166_altered_tumor_susceptibility1.85770620
36MP0000689_abnormal_spleen_morphology1.77539198
37MP0001986_abnormal_taste_sensitivity1.76808839
38MP0005025_abnormal_response_to1.69456203
39MP0002722_abnormal_immune_system1.67837870
40MP0008058_abnormal_DNA_repair1.65281077
41MP0004272_abnormal_basement_membrane1.65262354
42MP0010094_abnormal_chromosome_stability1.62478857
43MP0008775_abnormal_heart_ventricle1.60470018
44MP0010368_abnormal_lymphatic_system1.60157137
45MP0000751_myopathy1.59540301
46MP0010155_abnormal_intestine_physiology1.59530895
47MP0003303_peritoneal_inflammation1.58262259
48MP0000716_abnormal_immune_system1.57336652
49MP0002420_abnormal_adaptive_immunity1.56798748
50MP0002429_abnormal_blood_cell1.56229143
51MP0001873_stomach_inflammation1.54603351
52MP0001819_abnormal_immune_cell1.54044297
53MP0001800_abnormal_humoral_immune1.53984062
54MP0002452_abnormal_antigen_presenting1.52368132
55MP0001853_heart_inflammation1.51887897
56MP0003693_abnormal_embryo_hatching1.50512106
57MP0003950_abnormal_plasma_membrane1.49561474
58MP0002723_abnormal_immune_serum1.48607870
59MP0001188_hyperpigmentation1.47800254
60MP0002877_abnormal_melanocyte_morpholog1.43195153
61MP0006292_abnormal_olfactory_placode1.42675861
62MP0001542_abnormal_bone_strength1.42466507
63MP0003828_pulmonary_edema1.41481354
64MP0002148_abnormal_hypersensitivity_rea1.41247880
65MP0002006_tumorigenesis1.40875684
66MP0003806_abnormal_nucleotide_metabolis1.39701760
67MP0005595_abnormal_vascular_smooth1.39628680
68MP0001661_extended_life_span1.39267446
69MP0003866_abnormal_defecation1.39200796
70MP0002108_abnormal_muscle_morphology1.37012389
71MP0000015_abnormal_ear_pigmentation1.29751545
72MP0005165_increased_susceptibility_to1.28693842
73MP0000703_abnormal_thymus_morphology1.28241447
74MP0003567_abnormal_fetal_cardiomyocyte1.27826965
75MP0004215_abnormal_myocardial_fiber1.27703680
76MP0005000_abnormal_immune_tolerance1.27495660
77MP0003646_muscle_fatigue1.26613536
78MP0008057_abnormal_DNA_replication1.26428525
79MP0003279_aneurysm1.26331186
80MP0001879_abnormal_lymphatic_vessel1.26095965
81MP0006276_abnormal_autonomic_nervous1.24951082
82MP0003718_maternal_effect1.24915366
83MP0006036_abnormal_mitochondrial_physio1.24573709
84MP0009384_cardiac_valve_regurgitation1.22053937
85MP0003077_abnormal_cell_cycle1.21477149
86MP0002419_abnormal_innate_immunity1.19839716
87MP0002138_abnormal_hepatobiliary_system1.19767043
88MP0003436_decreased_susceptibility_to1.14265359
89MP0005620_abnormal_muscle_contractility1.13362475
90MP0002938_white_spotting1.09908448
91MP0001544_abnormal_cardiovascular_syste1.09084848
92MP0005385_cardiovascular_system_phenoty1.09084848
93MP0006138_congestive_heart_failure1.08811577
94MP0003252_abnormal_bile_duct1.07423442
95MP0004084_abnormal_cardiac_muscle1.07333321
96MP0002019_abnormal_tumor_incidence1.04258320
97MP0004484_altered_response_of1.04211232
98MP0000681_abnormal_thyroid_gland1.02880692
99MP0000343_altered_response_to1.02838410
100MP0002971_abnormal_brown_adipose1.01524039
101MP0005508_abnormal_skeleton_morphology1.01522595
102MP0000749_muscle_degeneration1.01422110
103MP0002295_abnormal_pulmonary_circulatio1.00104906
104MP0002132_abnormal_respiratory_system0.95144564
105MP0003959_abnormal_lean_body0.94348518
106MP0009333_abnormal_splenocyte_physiolog0.94296593
107MP0005387_immune_system_phenotype0.94029872
108MP0001790_abnormal_immune_system0.94029872
109MP0000313_abnormal_cell_death0.93416168
110MP0005410_abnormal_fertilization0.92159607
111MP0005390_skeleton_phenotype0.92152925
112MP0003868_abnormal_feces_composition0.90461780
113MP0004957_abnormal_blastocyst_morpholog0.90382596
114MP0010386_abnormal_urinary_bladder0.90217656
115MP0002405_respiratory_system_inflammati0.90168908
116MP0005369_muscle_phenotype0.89189941
117MP0000759_abnormal_skeletal_muscle0.87715145
118MP0005666_abnormal_adipose_tissue0.87674169
119MP0001664_abnormal_digestion0.87390578
120MP0001851_eye_inflammation0.87265026
121MP0001845_abnormal_inflammatory_respons0.87215516
122MP0000372_irregular_coat_pigmentation0.86946159
123MP0002075_abnormal_coat/hair_pigmentati0.86507187
124MP0003172_abnormal_lysosome_physiology0.82680159
125MP0005409_darkened_coat_color0.82514319
126MP0005535_abnormal_body_temperature0.82194228
127MP0001533_abnormal_skeleton_physiology0.81207358
128MP0008469_abnormal_protein_level0.80315201
129MP0002106_abnormal_muscle_physiology0.79597725
130MP0000249_abnormal_blood_vessel0.79407615
131MP0004087_abnormal_muscle_fiber0.76827507
132MP0002972_abnormal_cardiac_muscle0.76825137
133MP0010352_gastrointestinal_tract_polyps0.76525835
134MP0005375_adipose_tissue_phenotype0.74800469
135MP0009250_abnormal_appendicular_skeleto0.73764044
136MP0010329_abnormal_lipoprotein_level0.72824100
137MP0004130_abnormal_muscle_cell0.72588133
138MP0000477_abnormal_intestine_morphology0.72166614
139MP0005084_abnormal_gallbladder_morpholo0.71337343
140MP0003045_fibrosis0.70395980
141MP0005330_cardiomyopathy0.69439948
142MP0001764_abnormal_homeostasis0.68908890
143MP0002127_abnormal_cardiovascular_syste0.68767999
144MP0005023_abnormal_wound_healing0.68646071
145MP0005171_absent_coat_pigmentation0.68095661
146MP0002128_abnormal_blood_circulation0.67026120
147MP0002009_preneoplasia0.66579197
148MP0002733_abnormal_thermal_nociception0.66495317
149MP0000598_abnormal_liver_morphology0.65407444
150MP0003186_abnormal_redox_activity0.65354366
151MP0002160_abnormal_reproductive_system0.64705779
152MP0009764_decreased_sensitivity_to0.64703093
153MP0004134_abnormal_chest_morphology0.64097295
154MP0002837_dystrophic_cardiac_calcinosis0.63748853
155MP0003656_abnormal_erythrocyte_physiolo0.63325355
156MP0001175_abnormal_lung_morphology0.62907330
157MP0003111_abnormal_nucleus_morphology0.62875549
158MP0005164_abnormal_response_to0.61388488
159MP0002928_abnormal_bile_duct0.60780945
160MP0003638_abnormal_response/metabolism_0.60406215
161MP0001348_abnormal_lacrimal_gland0.60211550
162MP0001293_anophthalmia0.58051563
163MP0002933_joint_inflammation0.57339946
164MP0003786_premature_aging0.56193032
165MP0001958_emphysema0.55351141
166MP0009765_abnormal_xenobiotic_induced0.55002697
167MP0003221_abnormal_cardiomyocyte_apopto0.54702662
168MP0002089_abnormal_postnatal_growth/wei0.54416070
169MP0009763_increased_sensitivity_to0.54061455

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)5.84012708
2Prolonged bleeding time (HP:0003010)5.60942537
3Aplastic anemia (HP:0001915)5.55672330
4Nemaline bodies (HP:0003798)4.82835599
5Petechiae (HP:0000967)4.78281553
6Abnormality of cells of the erythroid lineage (HP:0012130)4.61094584
7Type 1 muscle fiber predominance (HP:0003803)4.61014284
8Muscle fiber inclusion bodies (HP:0100299)4.53698495
9Abnormal number of erythroid precursors (HP:0012131)4.49828223
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.48706433
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.15872851
12IgM deficiency (HP:0002850)4.02147625
13Aortic aneurysm (HP:0004942)3.94203930
14Chronic otitis media (HP:0000389)3.93830082
15Epistaxis (HP:0000421)3.77100606
16Type 2 muscle fiber atrophy (HP:0003554)3.69530645
17Reduced antithrombin III activity (HP:0001976)3.68075967
18Reticulocytopenia (HP:0001896)3.65450591
19Purpura (HP:0000979)3.61355939
20Muscle fiber atrophy (HP:0100295)3.60371331
21Myositis (HP:0100614)3.59268024
22Impaired platelet aggregation (HP:0003540)3.55357413
23Abnormal platelet function (HP:0011869)3.55357413
24Type I transferrin isoform profile (HP:0003642)3.45995894
25Acute myeloid leukemia (HP:0004808)3.44314298
26Protrusio acetabuli (HP:0003179)3.34961809
27Aortic dissection (HP:0002647)3.34216977
28Amaurosis fugax (HP:0100576)3.31410488
29Abnormal platelet volume (HP:0011876)3.16070896
30Premature rupture of membranes (HP:0001788)3.07771396
31Elevated erythrocyte sedimentation rate (HP:0003565)3.06415385
32Rhabdomyolysis (HP:0003201)3.02708688
33Gingival bleeding (HP:0000225)2.99618665
34Pallor (HP:0000980)2.97807589
35Abnormality of skeletal muscle fiber size (HP:0012084)2.96311940
36Facial diplegia (HP:0001349)2.89801988
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.85933623
38Increased mean platelet volume (HP:0011877)2.79193063
39Abnormal delivery (HP:0001787)2.77755024
40Myelodysplasia (HP:0002863)2.77279145
41Acute lymphatic leukemia (HP:0006721)2.74325669
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.73700270
43Abnormal protein N-linked glycosylation (HP:0012347)2.73700270
44Abnormal protein glycosylation (HP:0012346)2.73700270
45Abnormal glycosylation (HP:0012345)2.73700270
46Menorrhagia (HP:0000132)2.73359301
47Spinal rigidity (HP:0003306)2.72944274
48Redundant skin (HP:0001582)2.72197809
49Abnormality of T cell physiology (HP:0011840)2.68843587
50Distal arthrogryposis (HP:0005684)2.68472244
51Mesomelia (HP:0003027)2.67151270
52Myoglobinuria (HP:0002913)2.65377517
53Round ear (HP:0100830)2.65371900
54Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60642405
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60642405
56Hypothermia (HP:0002045)2.60246456
57Follicular hyperkeratosis (HP:0007502)2.57395848
58Colon cancer (HP:0003003)2.55522725
59Panhypogammaglobulinemia (HP:0003139)2.55142467
60Syringomyelia (HP:0003396)2.54435448
61Spinal cord lesions (HP:0100561)2.54435448
62Fatigue (HP:0012378)2.52790758
63Increased variability in muscle fiber diameter (HP:0003557)2.52255026
64Peritonitis (HP:0002586)2.52210356
65Albinism (HP:0001022)2.52093525
66Pancytopenia (HP:0001876)2.51768084
67Breech presentation (HP:0001623)2.51037760
68Abnormality of the nasal mucosa (HP:0000433)2.51004424
69Dyschromatopsia (HP:0007641)2.49659242
70Nonprogressive disorder (HP:0003680)2.49361307
71Exercise-induced myalgia (HP:0003738)2.47791103
72Ulnar deviation of the wrist (HP:0003049)2.47482213
73Absent phalangeal crease (HP:0006109)2.47111384
74Neck muscle weakness (HP:0000467)2.46369692
75Abnormality of the prostate (HP:0008775)2.44580651
76Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.37414531
77Recurrent bronchitis (HP:0002837)2.36093854
78Arterial thrombosis (HP:0004420)2.35227373
79Bruising susceptibility (HP:0000978)2.30726866
80Weak cry (HP:0001612)2.30451123
81Cellulitis (HP:0100658)2.27856345
82Recurrent viral infections (HP:0004429)2.27435491
83Patchy hypopigmentation of hair (HP:0011365)2.25135189
84Central scotoma (HP:0000603)2.24631983
85Abnormal biliary tract physiology (HP:0012439)2.23064105
86Bile duct proliferation (HP:0001408)2.23064105
87Myotonia (HP:0002486)2.23056682
88Muscle hypertrophy of the lower extremities (HP:0008968)2.22619882
8911 pairs of ribs (HP:0000878)2.20504676
90Orchitis (HP:0100796)2.19347865
91Spontaneous hematomas (HP:0007420)2.17137406
92Microcytic anemia (HP:0001935)2.16747118
93Soft skin (HP:0000977)2.13900875
94Type II lissencephaly (HP:0007260)2.13058761
95Gonadotropin excess (HP:0000837)2.13038475
96Abnormality of the columella (HP:0009929)2.12836494
97Hyperthyroidism (HP:0000836)2.11479123
98Rimmed vacuoles (HP:0003805)2.10710071
99Renal cortical cysts (HP:0000803)2.09847276
100Abnormality of the phalanges of the 5th finger (HP:0004213)2.08367649
101Macrocytic anemia (HP:0001972)2.08094393
102Decreased skull ossification (HP:0004331)2.06802668
103Increased intramyocellular lipid droplets (HP:0012240)2.05514736
104Beaking of vertebral bodies (HP:0004568)2.04875073
105Cerebral palsy (HP:0100021)2.04682844
106Poikiloderma (HP:0001029)2.04119672
107Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.03229153
108Short 1st metacarpal (HP:0010034)2.03229153
109Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01797418
110Slender build (HP:0001533)2.01432779
111Ragged-red muscle fibers (HP:0003200)2.00773161
112Abnormal pupillary function (HP:0007686)2.00548571
113Metaphyseal dysplasia (HP:0100255)1.99727109
114Agammaglobulinemia (HP:0004432)1.99089521
115Increased muscle lipid content (HP:0009058)1.98434045
116Areflexia of lower limbs (HP:0002522)1.96605163
117Abnormality of the renal cortex (HP:0011035)1.95768204
118Hepatocellular necrosis (HP:0001404)1.94780520
119Abnormality of fatty-acid metabolism (HP:0004359)1.94686816
120Abnormal finger flexion creases (HP:0006143)1.94025593
121Muscle stiffness (HP:0003552)1.93637951
122Chest pain (HP:0100749)1.93529330
123Bladder diverticulum (HP:0000015)1.92519728
124Tinnitus (HP:0000360)1.90488157
125Lymphoma (HP:0002665)1.90144732
126Hepatic necrosis (HP:0002605)1.89675694
127B lymphocytopenia (HP:0010976)1.86613322
128Abnormality of B cell number (HP:0010975)1.86613322
129Exertional dyspnea (HP:0002875)1.86223333
130Gastrointestinal stroma tumor (HP:0100723)1.85755785
131Erythema (HP:0010783)1.85492570
132Venous insufficiency (HP:0005293)1.84939963
133Hypoproteinemia (HP:0003075)1.84866305
134Abnormality of T cells (HP:0002843)1.84849385
135Nasal polyposis (HP:0100582)1.84214435
136Deformed tarsal bones (HP:0008119)1.84113588
137Encephalitis (HP:0002383)1.82603810
138Polycythemia (HP:0001901)1.81700094
139Migraine (HP:0002076)1.81375995
140Abnormality of skull ossification (HP:0002703)1.81031037
141Spontaneous abortion (HP:0005268)1.80723637
142Asplenia (HP:0001746)1.79622555
143Retrobulbar optic neuritis (HP:0100654)1.79130649
144Optic neuritis (HP:0100653)1.79130649
145Generalized aminoaciduria (HP:0002909)1.78561213
146Oligomenorrhea (HP:0000876)1.78359497
147IgG deficiency (HP:0004315)1.78159248
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76992810
149Calf muscle hypertrophy (HP:0008981)1.76561653
150Medulloblastoma (HP:0002885)1.76244127
151Radial bowing (HP:0002986)1.76168229
152Esophageal neoplasm (HP:0100751)1.76106044
153Neoplasm of head and neck (HP:0012288)1.76106044
154Abnormality of macular pigmentation (HP:0008002)1.75687313
155Hypoplasia of the thymus (HP:0000778)1.75637225
156Abnormality of the costochondral junction (HP:0000919)1.75167046
157Broad face (HP:0000283)1.75100196
158Brushfield spots (HP:0001088)1.74781303
159Muscle fiber splitting (HP:0003555)1.73988438
160Autoimmune hemolytic anemia (HP:0001890)1.73507599
161Neutropenia (HP:0001875)1.73311188
162Fragile skin (HP:0001030)1.71303133
163Abnormality of the 1st metacarpal (HP:0010009)1.70155772
164Dilatation of the ascending aorta (HP:0005111)1.69323407
165Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67616281
166Infantile muscular hypotonia (HP:0008947)1.67092001
167Pancreatic cysts (HP:0001737)1.65773101
168Venous abnormality (HP:0002624)1.65025416
169Abolished electroretinogram (ERG) (HP:0000550)1.63246604
170Ankle contracture (HP:0006466)1.63204895
171Insulin-resistant diabetes mellitus (HP:0000831)1.62996962
172Potter facies (HP:0002009)1.58401193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KIT3.46792656
2TNIK3.23806931
3TGFBR13.22430377
4TIE13.17117464
5MUSK2.87065661
6NME22.69180679
7EEF2K2.67677068
8MAP4K22.64446061
9MKNK12.52966381
10BTK2.50497511
11FLT32.46661803
12TEC2.45306588
13MAP4K12.26797443
14STK162.20358960
15WEE12.16084212
16ACVR1B2.09725349
17MAPKAPK52.06663302
18MATK2.05217332
19NUAK12.02777603
20JAK31.99452764
21MAP2K31.94170162
22TGFBR21.93635608
23CSF1R1.80188457
24RPS6KB21.78089351
25CDK191.66597064
26CDK81.57420317
27MAP3K121.53765247
28BRSK21.53330684
29BCKDK1.50317802
30PAK21.41698621
31FRK1.39814038
32ERN11.39743010
33ZAP701.38924470
34PHKG21.37223289
35PHKG11.37223289
36MKNK21.35413794
37MYLK1.34214547
38PBK1.27180275
39PKN21.26602269
40MAPKAPK31.25867311
41PIM21.21199553
42VRK11.20501232
43DAPK21.19495807
44CCNB11.18876196
45TXK1.18525503
46SYK1.18155128
47CDC71.15927001
48ADRBK11.15686607
49PLK41.10117088
50GRK51.07728926
51MAP2K61.05363641
52DYRK31.03682651
53MAP3K61.03005346
54PTK2B1.02307762
55CAMKK20.99851644
56NLK0.99367673
57TTN0.99011144
58PASK0.98816675
59GRK10.96070860
60PIK3CA0.94546221
61PIK3CG0.94183698
62IKBKE0.93193676
63PRKG20.93033403
64PLK20.91104424
65TNK20.89755668
66TBK10.87918693
67VRK20.87810557
68BMX0.86902461
69IKBKB0.85959423
70ATR0.84465302
71EIF2AK30.80916385
72CAMK10.78785208
73LYN0.77960196
74LRRK20.77622920
75SRPK10.77168844
76EIF2AK10.76600777
77CDK70.76289557
78ITK0.74362053
79MAP2K10.73016439
80IRAK40.71371939
81LCK0.71348534
82GRK70.69320112
83PIM10.69285071
84KDR0.68997302
85CLK10.67857650
86RIPK40.67477132
87TRPM70.66847454
88DDR20.65708162
89PDGFRA0.65592772
90MAPK40.64480162
91GRK60.63386307
92FES0.62766029
93MAPK120.62733170
94FER0.61828416
95ABL10.61673654
96ILK0.61403775
97DAPK30.61052371
98SCYL20.60750389
99PAK40.60248836
100IGF1R0.60235851
101CSNK1G30.59878892
102BMPR20.59223327
103MAP3K140.58957019
104ABL20.58290457
105MAPK70.56912664
106CDK30.56212307
107LATS10.54977947
108HIPK20.53082433
109MAP3K50.52693037
110CDK40.52678803
111DAPK10.51017135
112ERBB30.50504428
113SIK30.49564225
114TAOK30.49552529
115TSSK60.48668234
116EIF2AK20.48453509
117CSNK1G10.48381854
118PRKG10.47863307
119TYK20.47755952
120STK30.46796638
121PINK10.45289449
122BMPR1B0.45063169
123RPS6KA60.44720894
124ADRBK20.44281802
125ZAK0.42787254
126RPS6KB10.42558033
127RPS6KA40.42207915
128PRKCQ0.41403952
129MAPK110.40992969
130HCK0.39186513
131MAP3K70.38182628
132CSNK1G20.38011074
133AURKB0.37852273
134RAF10.36533310
135RPS6KA50.34453345
136MAPK30.33983043
137MAP3K130.33454173
138CHUK0.33411576
139NEK90.33279655
140BLK0.32581545
141OBSCN0.30901827
142NEK20.30323780
143FGFR30.27041287
144RPS6KL10.26892276
145RPS6KC10.26892276

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.83063982
2Ribosome_Homo sapiens_hsa030104.73556873
3Mismatch repair_Homo sapiens_hsa034303.61205034
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.96342204
5Base excision repair_Homo sapiens_hsa034102.83635984
6Nucleotide excision repair_Homo sapiens_hsa034202.36387105
7Pyrimidine metabolism_Homo sapiens_hsa002402.28062141
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22175690
9Homologous recombination_Homo sapiens_hsa034402.19659666
10Spliceosome_Homo sapiens_hsa030402.07374851
11Nitrogen metabolism_Homo sapiens_hsa009101.99822431
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.98775327
13RNA polymerase_Homo sapiens_hsa030201.98000208
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95407956
15Fatty acid elongation_Homo sapiens_hsa000621.94048333
16Propanoate metabolism_Homo sapiens_hsa006401.91731415
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.84752896
18RNA degradation_Homo sapiens_hsa030181.84635198
19Platelet activation_Homo sapiens_hsa046111.83795903
20Caffeine metabolism_Homo sapiens_hsa002321.77934685
21Olfactory transduction_Homo sapiens_hsa047401.71159913
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.68499325
23Primary immunodeficiency_Homo sapiens_hsa053401.66123689
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.63770359
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62807197
26Cell cycle_Homo sapiens_hsa041101.60619156
27Peroxisome_Homo sapiens_hsa041461.59631740
28Renin secretion_Homo sapiens_hsa049241.56936793
29Dilated cardiomyopathy_Homo sapiens_hsa054141.55411626
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55110623
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54667854
32Herpes simplex infection_Homo sapiens_hsa051681.51758405
33Hematopoietic cell lineage_Homo sapiens_hsa046401.51282566
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.49431540
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46475665
36N-Glycan biosynthesis_Homo sapiens_hsa005101.41709591
37Measles_Homo sapiens_hsa051621.35448175
38B cell receptor signaling pathway_Homo sapiens_hsa046621.30732252
39Purine metabolism_Homo sapiens_hsa002301.30675039
40Non-homologous end-joining_Homo sapiens_hsa034501.29786236
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.27562035
42Fanconi anemia pathway_Homo sapiens_hsa034601.26767185
43Leishmaniasis_Homo sapiens_hsa051401.25046539
44Thyroid cancer_Homo sapiens_hsa052161.24472861
45RNA transport_Homo sapiens_hsa030131.23129663
46Acute myeloid leukemia_Homo sapiens_hsa052211.22497202
47Glutathione metabolism_Homo sapiens_hsa004801.22361272
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.21014796
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.16640825
50Basal transcription factors_Homo sapiens_hsa030221.11018102
51Salivary secretion_Homo sapiens_hsa049701.10681515
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10301555
53Proteasome_Homo sapiens_hsa030501.08853141
54Autoimmune thyroid disease_Homo sapiens_hsa053201.08702880
55Linoleic acid metabolism_Homo sapiens_hsa005911.08387162
56Tryptophan metabolism_Homo sapiens_hsa003801.08152805
57Graft-versus-host disease_Homo sapiens_hsa053321.06369595
58Folate biosynthesis_Homo sapiens_hsa007901.05435397
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.04820184
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03767746
61Antigen processing and presentation_Homo sapiens_hsa046121.03120866
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01939231
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00789558
64Protein export_Homo sapiens_hsa030601.00438527
65Shigellosis_Homo sapiens_hsa051311.00349367
66cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00237794
67NF-kappa B signaling pathway_Homo sapiens_hsa040641.00035909
68Glycerolipid metabolism_Homo sapiens_hsa005610.99835264
69Focal adhesion_Homo sapiens_hsa045100.99561629
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98910603
71Fatty acid degradation_Homo sapiens_hsa000710.97300384
72Long-term depression_Homo sapiens_hsa047300.95090780
73p53 signaling pathway_Homo sapiens_hsa041150.94514186
74Phototransduction_Homo sapiens_hsa047440.94203926
75Calcium signaling pathway_Homo sapiens_hsa040200.93433638
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91938992
77Legionellosis_Homo sapiens_hsa051340.90652151
78Oxytocin signaling pathway_Homo sapiens_hsa049210.89724951
79Butanoate metabolism_Homo sapiens_hsa006500.88813846
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.88480126
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88057257
82Ovarian steroidogenesis_Homo sapiens_hsa049130.87048003
83Galactose metabolism_Homo sapiens_hsa000520.85894229
84Systemic lupus erythematosus_Homo sapiens_hsa053220.84253985
85Hepatitis B_Homo sapiens_hsa051610.83950846
86Sulfur relay system_Homo sapiens_hsa041220.83792568
87Malaria_Homo sapiens_hsa051440.83522207
88PPAR signaling pathway_Homo sapiens_hsa033200.81048925
89Fatty acid metabolism_Homo sapiens_hsa012120.80356167
90beta-Alanine metabolism_Homo sapiens_hsa004100.79344922
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.75193994
92Tyrosine metabolism_Homo sapiens_hsa003500.74959941
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74147168
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73909497
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73767383
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73477517
97Influenza A_Homo sapiens_hsa051640.70217266
98Amoebiasis_Homo sapiens_hsa051460.68738634
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.68630670
100Parkinsons disease_Homo sapiens_hsa050120.67993703
101Chronic myeloid leukemia_Homo sapiens_hsa052200.67372772
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66889883
103Epstein-Barr virus infection_Homo sapiens_hsa051690.65813472
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65435783
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63652708
106Serotonergic synapse_Homo sapiens_hsa047260.63516717
107Staphylococcus aureus infection_Homo sapiens_hsa051500.63264709
108Viral myocarditis_Homo sapiens_hsa054160.62846492
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62683647
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.62675522
111Regulation of autophagy_Homo sapiens_hsa041400.62122159
112Type I diabetes mellitus_Homo sapiens_hsa049400.61961174
113Pyruvate metabolism_Homo sapiens_hsa006200.61953515
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60473688
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59947830
116Chemical carcinogenesis_Homo sapiens_hsa052040.59771952
117Toxoplasmosis_Homo sapiens_hsa051450.58888083
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58743930
119Pertussis_Homo sapiens_hsa051330.58549839
120Melanoma_Homo sapiens_hsa052180.56291644
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55788745
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55722152
123Cardiac muscle contraction_Homo sapiens_hsa042600.54807716
124Other glycan degradation_Homo sapiens_hsa005110.54760271
125Small cell lung cancer_Homo sapiens_hsa052220.54301691
126Arachidonic acid metabolism_Homo sapiens_hsa005900.54171999
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.53805342
128Osteoclast differentiation_Homo sapiens_hsa043800.53801198
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53734626
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53497891
131One carbon pool by folate_Homo sapiens_hsa006700.53203430
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53075893
133Protein digestion and absorption_Homo sapiens_hsa049740.51456750
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51055971
135HTLV-I infection_Homo sapiens_hsa051660.50400268
136Gap junction_Homo sapiens_hsa045400.49978233
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49330037
138Apoptosis_Homo sapiens_hsa042100.47964327
139Viral carcinogenesis_Homo sapiens_hsa052030.47184194
140Carbon metabolism_Homo sapiens_hsa012000.46354492
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46351582
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45289910
143Pentose phosphate pathway_Homo sapiens_hsa000300.45233156
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44581957
145Non-small cell lung cancer_Homo sapiens_hsa052230.44512720
146TNF signaling pathway_Homo sapiens_hsa046680.42129475
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.41969745
148Asthma_Homo sapiens_hsa053100.40572811
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40247816
150Metabolic pathways_Homo sapiens_hsa011000.38961902
151Circadian entrainment_Homo sapiens_hsa047130.37952886
152* Rheumatoid arthritis_Homo sapiens_hsa053230.36996128
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33901095
154Prolactin signaling pathway_Homo sapiens_hsa049170.32479167
155Allograft rejection_Homo sapiens_hsa053300.30886055
156Notch signaling pathway_Homo sapiens_hsa043300.30657953
157Cysteine and methionine metabolism_Homo sapiens_hsa002700.30089160
158Selenocompound metabolism_Homo sapiens_hsa004500.29554546
159Hepatitis C_Homo sapiens_hsa051600.29190695
160Neurotrophin signaling pathway_Homo sapiens_hsa047220.27501079
161ECM-receptor interaction_Homo sapiens_hsa045120.27382032
162mRNA surveillance pathway_Homo sapiens_hsa030150.26501697
163Central carbon metabolism in cancer_Homo sapiens_hsa052300.25884792
164Pathways in cancer_Homo sapiens_hsa052000.24948272

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »