ANAPC7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.79397808
2nuclear pore complex assembly (GO:0051292)4.68483841
3synapsis (GO:0007129)4.59459211
4purine nucleobase biosynthetic process (GO:0009113)4.50727532
5nucleobase biosynthetic process (GO:0046112)4.50172230
6DNA deamination (GO:0045006)4.49768003
7DNA replication checkpoint (GO:0000076)4.35650037
8formation of translation preinitiation complex (GO:0001731)4.33027940
9nuclear pore organization (GO:0006999)4.31916746
10mitotic metaphase plate congression (GO:0007080)4.24594427
11ribosomal small subunit assembly (GO:0000028)4.17019492
12spliceosomal snRNP assembly (GO:0000387)4.06230640
13ribosome biogenesis (GO:0042254)4.04500934
14ribosome assembly (GO:0042255)4.04340534
15DNA replication initiation (GO:0006270)3.97328789
16meiotic chromosome segregation (GO:0045132)3.94659799
17viral transcription (GO:0019083)3.94397000
18sister chromatid segregation (GO:0000819)3.92050437
19mitotic chromosome condensation (GO:0007076)3.90593467
20DNA strand elongation involved in DNA replication (GO:0006271)3.90144024
21piRNA metabolic process (GO:0034587)3.88641278
22protein localization to kinetochore (GO:0034501)3.85674194
23ribosomal large subunit biogenesis (GO:0042273)3.84730660
24translational termination (GO:0006415)3.84493471
25DNA strand elongation (GO:0022616)3.78175349
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77703198
27ribonucleoprotein complex biogenesis (GO:0022613)3.74964974
28DNA unwinding involved in DNA replication (GO:0006268)3.70618367
29translational initiation (GO:0006413)3.69948719
30tRNA methylation (GO:0030488)3.66674577
31establishment of integrated proviral latency (GO:0075713)3.65104629
32mitotic nuclear envelope disassembly (GO:0007077)3.63565961
33viral mRNA export from host cell nucleus (GO:0046784)3.63471449
34chromosome organization involved in meiosis (GO:0070192)3.60007499
35pore complex assembly (GO:0046931)3.58452003
36spliceosomal complex assembly (GO:0000245)3.57051891
37DNA synthesis involved in DNA repair (GO:0000731)3.56455843
38mitotic sister chromatid cohesion (GO:0007064)3.55614822
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52577646
40peptidyl-arginine omega-N-methylation (GO:0035247)3.51807242
41regulation of centriole replication (GO:0046599)3.51632148
42translational elongation (GO:0006414)3.50828186
43somatic hypermutation of immunoglobulin genes (GO:0016446)3.50390336
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50390336
45regulation of translational fidelity (GO:0006450)3.49455407
46telomere maintenance via semi-conservative replication (GO:0032201)3.48879597
47rRNA processing (GO:0006364)3.41566758
48metaphase plate congression (GO:0051310)3.36652330
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.35268428
50folic acid metabolic process (GO:0046655)3.33143660
51histone exchange (GO:0043486)3.32959102
52membrane disassembly (GO:0030397)3.32873940
53nuclear envelope disassembly (GO:0051081)3.32873940
54pseudouridine synthesis (GO:0001522)3.32618519
55protein localization to chromosome, centromeric region (GO:0071459)3.32321097
56rRNA metabolic process (GO:0016072)3.32271623
57double-strand break repair via nonhomologous end joining (GO:0006303)3.30494880
58non-recombinational repair (GO:0000726)3.30494880
59rRNA modification (GO:0000154)3.30102215
60resolution of meiotic recombination intermediates (GO:0000712)3.29369476
61DNA methylation involved in gamete generation (GO:0043046)3.27633117
62telomere maintenance via recombination (GO:0000722)3.27139168
63negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.26920427
64DNA double-strand break processing (GO:0000729)3.26089132
65IMP biosynthetic process (GO:0006188)3.24953084
66folic acid-containing compound biosynthetic process (GO:0009396)3.24272237
67DNA ligation (GO:0006266)3.22461524
68regulation of spindle organization (GO:0090224)3.22336763
69positive regulation of chromosome segregation (GO:0051984)3.21781055
70histone arginine methylation (GO:0034969)3.21579477
71negative regulation of translational initiation (GO:0045947)3.20756879
72tRNA aminoacylation for protein translation (GO:0006418)3.20531528
73amino acid activation (GO:0043038)3.20326720
74tRNA aminoacylation (GO:0043039)3.20326720
75DNA catabolic process, exonucleolytic (GO:0000738)3.19799314
76ribosomal small subunit biogenesis (GO:0042274)3.18858444
77DNA topological change (GO:0006265)3.18319332
78transcription from mitochondrial promoter (GO:0006390)3.14733922
79DNA replication-dependent nucleosome assembly (GO:0006335)3.12421375
80DNA replication-dependent nucleosome organization (GO:0034723)3.12421375
81nucleotide-excision repair, DNA gap filling (GO:0006297)3.09458199
82mitotic sister chromatid segregation (GO:0000070)3.09171096
83kinetochore assembly (GO:0051382)3.07540131
84regulation of centrosome cycle (GO:0046605)3.06850460
85* negative regulation of chromosome segregation (GO:0051985)3.05141765
86sister chromatid cohesion (GO:0007062)3.04089188
87mitotic recombination (GO:0006312)3.02270306
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02264191
89DNA duplex unwinding (GO:0032508)3.01424838
90* regulation of chromosome segregation (GO:0051983)3.00542724
91negative regulation of RNA splicing (GO:0033119)3.00150701
92mitochondrial RNA metabolic process (GO:0000959)2.99755865
93RNA splicing, via transesterification reactions (GO:0000375)2.99482967
94mitochondrial DNA metabolic process (GO:0032042)2.99117635
95RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99074248
96mRNA splicing, via spliceosome (GO:0000398)2.99074248
97DNA geometric change (GO:0032392)2.98980910
98cellular protein complex disassembly (GO:0043624)2.98954176
99viral life cycle (GO:0019058)2.97174120
100protein K6-linked ubiquitination (GO:0085020)2.96291133
101peptidyl-arginine N-methylation (GO:0035246)2.96250630
102peptidyl-arginine methylation (GO:0018216)2.96250630
103* mitotic spindle assembly checkpoint (GO:0007094)2.95583578
104* negative regulation of mitotic sister chromatid separation (GO:2000816)2.95095103
105* negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95095103
106* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95095103
107* negative regulation of sister chromatid segregation (GO:0033046)2.95095103
108kinetochore organization (GO:0051383)2.94978807
109chromatin remodeling at centromere (GO:0031055)2.93454040
110attachment of spindle microtubules to kinetochore (GO:0008608)2.92964455
111male meiosis I (GO:0007141)2.91674473
112chromosome segregation (GO:0007059)2.91647013
113protein targeting to ER (GO:0045047)2.91598299
114* spindle assembly checkpoint (GO:0071173)2.91546748
115cotranslational protein targeting to membrane (GO:0006613)2.91507322
116replication fork processing (GO:0031297)2.91497478
117* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91021552
118male meiosis (GO:0007140)2.90955227
119* anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89022324
120protein complex disassembly (GO:0043241)2.88764179
121CENP-A containing nucleosome assembly (GO:0034080)2.88575610
122ATP-dependent chromatin remodeling (GO:0043044)2.88442423
123* spindle checkpoint (GO:0031577)2.87894558
124telomere maintenance via telomere lengthening (GO:0010833)2.87717475
125synaptonemal complex assembly (GO:0007130)2.87242996
126* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.87156763
127regulation of centrosome duplication (GO:0010824)2.86931548
128DNA replication-independent nucleosome organization (GO:0034724)2.86275692
129DNA replication-independent nucleosome assembly (GO:0006336)2.86275692
130meiotic nuclear division (GO:0007126)2.85561641
131ribonucleoprotein complex assembly (GO:0022618)2.85433377
132* regulation of sister chromatid segregation (GO:0033045)2.85247834
133* regulation of mitotic sister chromatid separation (GO:0010965)2.85247834
134* regulation of mitotic sister chromatid segregation (GO:0033047)2.85247834
135L-serine metabolic process (GO:0006563)2.84892998
136regulation of sister chromatid cohesion (GO:0007063)2.84481919
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84049918
138rRNA methylation (GO:0031167)2.83505738
139histone H2A acetylation (GO:0043968)2.83492961
140* mitotic spindle checkpoint (GO:0071174)2.83083582
141establishment of chromosome localization (GO:0051303)2.82914508
142mitochondrial DNA replication (GO:0006264)2.82640568
143* regulation of mitotic metaphase/anaphase transition (GO:0030071)2.82531387
144termination of RNA polymerase II transcription (GO:0006369)2.82033240
145negative regulation of DNA-templated transcription, elongation (GO:0032785)2.81944142
146negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.81944142
147meiosis I (GO:0007127)2.79837698
148base-excision repair (GO:0006284)2.78692264
149regulation of nuclear cell cycle DNA replication (GO:0033262)2.77790614
150IMP metabolic process (GO:0046040)2.77555985
151paraxial mesoderm development (GO:0048339)2.77386182

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.59494968
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.02963697
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.94650580
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64209924
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98282749
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96030006
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92410329
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76388512
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.72652688
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72214374
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62930236
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61641351
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53785539
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.42249900
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39668756
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.37041366
17XRN2_22483619_ChIP-Seq_HELA_Human2.32339749
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.22480875
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21643571
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19386870
21MYC_22102868_ChIP-Seq_BL_Human2.14330302
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99947735
23CIITA_25753668_ChIP-Seq_RAJI_Human1.97376197
24* VDR_23849224_ChIP-Seq_CD4+_Human1.92470387
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90891208
26DCP1A_22483619_ChIP-Seq_HELA_Human1.90861926
27* GABP_19822575_ChIP-Seq_HepG2_Human1.89889687
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86104699
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81638623
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81473167
31* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81422927
32FOXP3_21729870_ChIP-Seq_TREG_Human1.80999427
33PADI4_21655091_ChIP-ChIP_MCF-7_Human1.78146806
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74727911
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73954479
36TTF2_22483619_ChIP-Seq_HELA_Human1.73446586
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73067886
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.70245109
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70163595
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68349824
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.66695086
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64380147
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58052623
44AR_21909140_ChIP-Seq_LNCAP_Human1.57117267
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.56369463
46* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52698773
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52015689
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.50634780
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48630270
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47912609
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46187068
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45711014
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44362949
54KDM5A_27292631_Chip-Seq_BREAST_Human1.44251693
55* VDR_21846776_ChIP-Seq_THP-1_Human1.43966479
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43053888
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38031162
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37986763
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37470685
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36368264
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.34220717
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33947991
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32242859
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.30529885
65* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29820611
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29141962
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29117513
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28898474
69* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28459154
70* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26353409
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25951801
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.25156452
73TFEB_21752829_ChIP-Seq_HELA_Human1.24601892
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22142622
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21491856
76SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17679668
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15120925
78ELK1_19687146_ChIP-ChIP_HELA_Human1.14043443
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12817532
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12698468
81HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11536145
82ZNF274_21170338_ChIP-Seq_K562_Hela1.10818418
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09626778
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09608919
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09237771
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07359157
87* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06371972
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06068531
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.05885260
90* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05373619
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03109537
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01058808
93ZNF263_19887448_ChIP-Seq_K562_Human1.00057909
94IGF1R_20145208_ChIP-Seq_DFB_Human0.98438897
95NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97510580
96EWS_26573619_Chip-Seq_HEK293_Human0.97286501
97OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96109344
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.95972940
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94589400
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93882912
101MYC_18940864_ChIP-ChIP_HL60_Human0.92302909
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90658728
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89926670
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.89870225
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89456924
106SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89040897
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88173949
108ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87970794
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.87651749
110SPI1_23547873_ChIP-Seq_NB4_Human0.86340257
111NANOG_16153702_ChIP-ChIP_HESCs_Human0.86231521
112YY1_22570637_ChIP-Seq_MALME-3M_Human0.86027387
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85916764
114ELK1_22589737_ChIP-Seq_MCF10A_Human0.85224875
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85223758
116FUS_26573619_Chip-Seq_HEK293_Human0.84476244
117IRF1_19129219_ChIP-ChIP_H3396_Human0.83387977
118KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.83250963
119CHD1_26751641_Chip-Seq_LNCaP_Human0.76768494
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76341604
121SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73188436
122* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72199648
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70985629
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68952358
125FOXP1_21924763_ChIP-Seq_HESCs_Human0.65164455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.11261783
2MP0003111_abnormal_nucleus_morphology4.45745243
3MP0010094_abnormal_chromosome_stability3.75041292
4MP0004957_abnormal_blastocyst_morpholog3.74836459
5MP0003077_abnormal_cell_cycle3.68926432
6MP0008057_abnormal_DNA_replication3.00511762
7MP0008058_abnormal_DNA_repair2.98181155
8MP0008007_abnormal_cellular_replicative2.85980712
9MP0002396_abnormal_hematopoietic_system2.28962850
10MP0008932_abnormal_embryonic_tissue2.27095551
11MP0001730_embryonic_growth_arrest2.19084484
12MP0000350_abnormal_cell_proliferation2.12541175
13MP0003123_paternal_imprinting2.07464554
14MP0003567_abnormal_fetal_cardiomyocyte2.00154187
15MP0005380_embryogenesis_phenotype1.89617277
16MP0001672_abnormal_embryogenesis/_devel1.89617277
17MP0003718_maternal_effect1.83009179
18MP0000490_abnormal_crypts_of1.78103035
19MP0009697_abnormal_copulation1.76417569
20MP0001697_abnormal_embryo_size1.76284933
21MP0010030_abnormal_orbit_morphology1.75564853
22MP0009278_abnormal_bone_marrow1.73202105
23MP0003786_premature_aging1.70094970
24MP0004808_abnormal_hematopoietic_stem1.68323805
25MP0006035_abnormal_mitochondrial_morpho1.68014993
26MP0009333_abnormal_splenocyte_physiolog1.65363750
27MP0003984_embryonic_growth_retardation1.65264761
28MP0002080_prenatal_lethality1.63067151
29MP0002088_abnormal_embryonic_growth/wei1.62529789
30MP0002653_abnormal_ependyma_morphology1.59097055
31MP0003315_abnormal_perineum_morphology1.57999005
32MP0008789_abnormal_olfactory_epithelium1.57724614
33MP0002085_abnormal_embryonic_tissue1.56022132
34MP0005397_hematopoietic_system_phenotyp1.53462739
35MP0001545_abnormal_hematopoietic_system1.53462739
36MP0010307_abnormal_tumor_latency1.47795773
37MP0000313_abnormal_cell_death1.47500221
38MP0001529_abnormal_vocalization1.41834291
39MP0008877_abnormal_DNA_methylation1.39727761
40MP0003890_abnormal_embryonic-extraembry1.39325635
41MP0002084_abnormal_developmental_patter1.38866769
42MP0002086_abnormal_extraembryonic_tissu1.37741794
43MP0003698_abnormal_male_reproductive1.29867136
44MP0002019_abnormal_tumor_incidence1.28951665
45MP0005499_abnormal_olfactory_system1.28930878
46MP0005394_taste/olfaction_phenotype1.28930878
47MP0010352_gastrointestinal_tract_polyps1.27162054
48MP0004233_abnormal_muscle_weight1.25383732
49MP0002132_abnormal_respiratory_system1.19826308
50MP0004197_abnormal_fetal_growth/weight/1.18535398
51MP0000750_abnormal_muscle_regeneration1.17150514
52MP0003221_abnormal_cardiomyocyte_apopto1.16082700
53MP0001346_abnormal_lacrimal_gland1.16065082
54MP0009840_abnormal_foam_cell1.14213412
55MP0004147_increased_porphyrin_level1.13993451
56MP0003878_abnormal_ear_physiology1.12628909
57MP0005377_hearing/vestibular/ear_phenot1.12628909
58MP0008260_abnormal_autophagy1.11775048
59MP0000647_abnormal_sebaceous_gland1.10756291
60MP0004084_abnormal_cardiac_muscle1.10240763
61MP0003119_abnormal_digestive_system1.09920901
62MP0006292_abnormal_olfactory_placode1.08803691
63MP0003941_abnormal_skin_development1.07331026
64MP0002938_white_spotting1.07244585
65MP0003806_abnormal_nucleotide_metabolis1.06786951
66MP0001293_anophthalmia1.05574928
67MP0000703_abnormal_thymus_morphology1.05099416
68MP0000428_abnormal_craniofacial_morphol1.04362701
69MP0002210_abnormal_sex_determination1.02173142
70MP0006072_abnormal_retinal_apoptosis1.00092125
71MP0002161_abnormal_fertility/fecundity0.96140514
72MP0009672_abnormal_birth_weight0.95575106
73MP0005451_abnormal_body_composition0.95129658
74MP0002722_abnormal_immune_system0.94234950
75MP0002697_abnormal_eye_size0.93530151
76MP0000358_abnormal_cell_content/0.93185367
77MP0003861_abnormal_nervous_system0.93039229
78MP0002751_abnormal_autonomic_nervous0.92336107
79MP0001145_abnormal_male_reproductive0.92179561
80MP0000631_abnormal_neuroendocrine_gland0.91173026
81MP0000689_abnormal_spleen_morphology0.90453426
82MP0003763_abnormal_thymus_physiology0.90446462
83MP0000733_abnormal_muscle_development0.90005529
84MP0002398_abnormal_bone_marrow0.89647737
85MP0006036_abnormal_mitochondrial_physio0.89217979
86MP0003136_yellow_coat_color0.89054683
87MP0002127_abnormal_cardiovascular_syste0.87707333
88MP0005076_abnormal_cell_differentiation0.84225102
89MP0005023_abnormal_wound_healing0.81598032
90MP0003121_genomic_imprinting0.81095801
91MP0003943_abnormal_hepatobiliary_system0.80474661
92MP0002102_abnormal_ear_morphology0.80212087
93MP0000566_synostosis0.79951752
94MP0003699_abnormal_female_reproductive0.79198349
95MP0001286_abnormal_eye_development0.77988105
96MP0003828_pulmonary_edema0.77833251
97MP0002092_abnormal_eye_morphology0.77498398
98MP0000427_abnormal_hair_cycle0.77271148
99MP0002095_abnormal_skin_pigmentation0.76783296
100MP0001188_hyperpigmentation0.76226346
101MP0001661_extended_life_span0.75718048
102MP0003186_abnormal_redox_activity0.75297367
103MP0005384_cellular_phenotype0.74339377
104MP0000858_altered_metastatic_potential0.74225804
105MP0002429_abnormal_blood_cell0.74051026
106MP0003937_abnormal_limbs/digits/tail_de0.73741540
107MP0002233_abnormal_nose_morphology0.73570923
108MP0000653_abnormal_sex_gland0.73007998
109MP0005621_abnormal_cell_physiology0.72420225
110MP0003566_abnormal_cell_adhesion0.71884167
111MP0002111_abnormal_tail_morphology0.71844094
112MP0003646_muscle_fatigue0.71260946
113MP0005389_reproductive_system_phenotype0.70953447
114MP0002932_abnormal_joint_morphology0.68172410
115MP0001929_abnormal_gametogenesis0.67789726
116MP0009053_abnormal_anal_canal0.67455214
117MP0002269_muscular_atrophy0.66600642
118MP0001119_abnormal_female_reproductive0.65891830
119MP0002184_abnormal_innervation0.64925122
120MP0000372_irregular_coat_pigmentation0.64751969
121MP0009703_decreased_birth_body0.64240835
122MP0001915_intracranial_hemorrhage0.64051891
123MP0003705_abnormal_hypodermis_morpholog0.62344690
124MP0000465_gastrointestinal_hemorrhage0.62043009
125MP0003935_abnormal_craniofacial_develop0.61267936
126MP0005501_abnormal_skin_physiology0.61147966
127MP0008995_early_reproductive_senescence0.60949268
128MP0000477_abnormal_intestine_morphology0.60290756
129MP0005330_cardiomyopathy0.60110572
130MP0004133_heterotaxia0.59986461
131MP0010630_abnormal_cardiac_muscle0.59809401
132MP0001984_abnormal_olfaction0.59348460
133MP0000049_abnormal_middle_ear0.58915927
134MP0002249_abnormal_larynx_morphology0.58643962
135MP0008770_decreased_survivor_rate0.58297274
136MP0005379_endocrine/exocrine_gland_phen0.58175745
137MP0001849_ear_inflammation0.58047065
138MP0003755_abnormal_palate_morphology0.57140502
139MP0002009_preneoplasia0.57001435
140MP0005391_vision/eye_phenotype0.56794965
141MP0000266_abnormal_heart_morphology0.56512073
142MP0005645_abnormal_hypothalamus_physiol0.56425961
143MP0002163_abnormal_gland_morphology0.55169776
144MP0002160_abnormal_reproductive_system0.55148422
145MP0000716_abnormal_immune_system0.54063780
146MP0005187_abnormal_penis_morphology0.53032824
147MP0005253_abnormal_eye_physiology0.52975654
148MP0005395_other_phenotype0.52757143

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.81587811
2Breast hypoplasia (HP:0003187)4.38206572
3Birth length less than 3rd percentile (HP:0003561)4.33471906
4Patellar aplasia (HP:0006443)4.31061030
5Aplasia/Hypoplasia of the patella (HP:0006498)4.20673982
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90222919
7Abnormality of cells of the erythroid lineage (HP:0012130)3.77537102
8Abnormal number of erythroid precursors (HP:0012131)3.73212188
9Chromsome breakage (HP:0040012)3.49933648
10Progressive muscle weakness (HP:0003323)3.15798178
11Congenital stationary night blindness (HP:0007642)3.14736717
12Carpal bone hypoplasia (HP:0001498)3.07391967
13Meckel diverticulum (HP:0002245)3.06578348
14Pallor (HP:0000980)3.05128710
15Selective tooth agenesis (HP:0001592)3.03300139
16Abnormality of the ileum (HP:0001549)3.01699278
17Microvesicular hepatic steatosis (HP:0001414)2.94728149
18Absent thumb (HP:0009777)2.89685768
19Cerebral hypomyelination (HP:0006808)2.83110982
20Abnormality of the preputium (HP:0100587)2.79361935
21Volvulus (HP:0002580)2.78988373
22Degeneration of anterior horn cells (HP:0002398)2.78075731
23Abnormality of the anterior horn cell (HP:0006802)2.78075731
24Aplastic anemia (HP:0001915)2.74605457
25Abnormal number of incisors (HP:0011064)2.74301978
26Increased nuchal translucency (HP:0010880)2.73291633
27Macrocytic anemia (HP:0001972)2.72831955
28Rough bone trabeculation (HP:0100670)2.67602199
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.65638841
30Microretrognathia (HP:0000308)2.61503863
31Abnormal lung lobation (HP:0002101)2.60282726
32Absent radius (HP:0003974)2.54863028
33Impulsivity (HP:0100710)2.53648665
34Sloping forehead (HP:0000340)2.51193750
35Premature ovarian failure (HP:0008209)2.47776070
36Oral leukoplakia (HP:0002745)2.47482203
37Multiple enchondromatosis (HP:0005701)2.41123284
38Myelodysplasia (HP:0002863)2.40774163
39Aplasia involving forearm bones (HP:0009822)2.35431211
40Absent forearm bone (HP:0003953)2.35431211
41Bone marrow hypocellularity (HP:0005528)2.33738113
42Entropion (HP:0000621)2.33517288
43Abnormality of DNA repair (HP:0003254)2.26770951
44IgM deficiency (HP:0002850)2.26651477
45Nephroblastoma (Wilms tumor) (HP:0002667)2.26471727
46Abnormality of chromosome stability (HP:0003220)2.26389112
47Secondary amenorrhea (HP:0000869)2.23814251
48Trismus (HP:0000211)2.22983631
49Neoplasm of the pancreas (HP:0002894)2.22436036
50Gonadotropin excess (HP:0000837)2.21572114
51Cortical dysplasia (HP:0002539)2.21569258
52Concave nail (HP:0001598)2.21032530
53Squamous cell carcinoma (HP:0002860)2.18939173
54Duplicated collecting system (HP:0000081)2.16833620
55Astrocytoma (HP:0009592)2.16257981
56Abnormality of the astrocytes (HP:0100707)2.16257981
57Ependymoma (HP:0002888)2.15433123
58Hypoplasia of the pons (HP:0012110)2.14712793
59Ureteral duplication (HP:0000073)2.14227264
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13654266
61Pelvic girdle muscle weakness (HP:0003749)2.13584914
62Horseshoe kidney (HP:0000085)2.13260466
63Abnormality of cochlea (HP:0000375)2.12109262
64Slender long bone (HP:0003100)2.11070988
65Embryonal renal neoplasm (HP:0011794)2.09611983
66Glioma (HP:0009733)2.09606323
67Triphalangeal thumb (HP:0001199)2.09067159
68Muscle fibrillation (HP:0010546)2.08217305
69Short thumb (HP:0009778)2.06437763
70Increased serum lactate (HP:0002151)2.05866685
71Abnormality of the renal collecting system (HP:0004742)2.04588071
72Abnormality of glycolysis (HP:0004366)2.04135205
73Abnormality of reticulocytes (HP:0004312)2.02221405
74Tongue fasciculations (HP:0001308)2.01050703
75Atresia of the external auditory canal (HP:0000413)2.01045578
76Tracheoesophageal fistula (HP:0002575)2.00305690
77Small intestinal stenosis (HP:0012848)1.99328206
78Duodenal stenosis (HP:0100867)1.99328206
79Colon cancer (HP:0003003)1.99310938
80Aplasia/Hypoplasia involving the musculature (HP:0001460)1.96514779
81Abnormality of the pons (HP:0007361)1.94538833
82Poikiloderma (HP:0001029)1.94330722
83Supernumerary spleens (HP:0009799)1.91657492
84Prominent nose (HP:0000448)1.91157561
85Difficulty climbing stairs (HP:0003551)1.90217977
86Sparse lateral eyebrow (HP:0005338)1.90012313
87Sclerocornea (HP:0000647)1.89739464
88Medulloblastoma (HP:0002885)1.88178260
89Preaxial hand polydactyly (HP:0001177)1.87547772
90Ectopic kidney (HP:0000086)1.87374920
91Increased hepatocellular lipid droplets (HP:0006565)1.86544257
92Premature graying of hair (HP:0002216)1.85943313
93Hyperglycinuria (HP:0003108)1.84762264
94Pancytopenia (HP:0001876)1.84474591
95Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84407818
96Progressive external ophthalmoplegia (HP:0000590)1.83969664
97Acute encephalopathy (HP:0006846)1.83517787
98Ankle contracture (HP:0006466)1.83504046
99Rhabdomyosarcoma (HP:0002859)1.81359700
100Abnormality of the duodenum (HP:0002246)1.81148564
101Proximal placement of thumb (HP:0009623)1.80745846
102Abnormality of pyrimidine metabolism (HP:0004353)1.80731231
103Increased CSF lactate (HP:0002490)1.80511382
104Lipid accumulation in hepatocytes (HP:0006561)1.79642533
105Deviation of the thumb (HP:0009603)1.79168994
106Optic nerve coloboma (HP:0000588)1.77932109
107Personality changes (HP:0000751)1.77857639
108High anterior hairline (HP:0009890)1.77248745
109Abnormality of the labia minora (HP:0012880)1.76897771
110Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76385988
111Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76385988
112Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75917029
113Abnormality of the carotid arteries (HP:0005344)1.75799259
114Cafe-au-lait spot (HP:0000957)1.75659202
115Muscle fiber atrophy (HP:0100295)1.74140139
116Acute necrotizing encephalopathy (HP:0006965)1.73834912
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.72888040
118Increased serum pyruvate (HP:0003542)1.72825716
119Shoulder girdle muscle weakness (HP:0003547)1.72085804
120Choanal atresia (HP:0000453)1.71963379
121Abnormal protein glycosylation (HP:0012346)1.69544261
122Abnormal glycosylation (HP:0012345)1.69544261
123Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69544261
124Abnormal protein N-linked glycosylation (HP:0012347)1.69544261
125Rib fusion (HP:0000902)1.68900379
126Preauricular skin tag (HP:0000384)1.68798130
127Abdominal situs inversus (HP:0003363)1.68421770
128Abnormality of abdominal situs (HP:0011620)1.68421770
129Clubbing of toes (HP:0100760)1.67878286
130Generalized amyotrophy (HP:0003700)1.67026339
131Type I transferrin isoform profile (HP:0003642)1.66680995
132Duplication of thumb phalanx (HP:0009942)1.65872012
133Aplasia/Hypoplasia of the sternum (HP:0006714)1.65651268
134Facial hemangioma (HP:0000329)1.65216747
135Astigmatism (HP:0000483)1.65019828
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.64338912
137Abnormal trabecular bone morphology (HP:0100671)1.64291822
138Morphological abnormality of the inner ear (HP:0011390)1.63093297
139Abnormal mitochondria in muscle tissue (HP:0008316)1.63038755
140Pustule (HP:0200039)1.62770550
141Spinal muscular atrophy (HP:0007269)1.62621762
142Pendular nystagmus (HP:0012043)1.61770878
143Abnormality of chromosome segregation (HP:0002916)1.61650725
144Postnatal microcephaly (HP:0005484)1.61293006
145Nephronophthisis (HP:0000090)1.58198973
146Aplasia/Hypoplasia of the earlobes (HP:0009906)1.57713928
147Hyperglycinemia (HP:0002154)1.57016268
148Arteriovenous malformation (HP:0100026)1.54659523
149Abnormality of alanine metabolism (HP:0010916)1.54416672
150Hyperalaninemia (HP:0003348)1.54416672
151Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.54416672
152Lactic acidosis (HP:0003128)1.54360832
153Neoplasm of the colon (HP:0100273)1.53175444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.88837510
2TLK14.01880165
3WEE14.01389906
4NEK22.96108336
5PBK2.94395372
6NME22.72619190
7NUAK12.52583799
8EIF2AK12.49975381
9VRK22.48925080
10STK162.39634882
11DYRK32.29104290
12ACVR1B2.28489203
13MAP3K102.28275241
14CDC72.24939958
15RPS6KA42.11976559
16TTK2.04119792
17SRPK12.02547113
18NEK11.93848552
19CDK71.86852242
20MKNK21.84803283
21EEF2K1.84612013
22* PLK11.78031044
23BRSK21.77802565
24LATS11.76233628
25PNCK1.71878084
26MKNK11.71167713
27CDK121.61792049
28RPS6KB21.55779030
29CDK41.55216137
30CHEK21.46825194
31CCNB11.45969206
32PLK41.45538363
33TSSK61.45203752
34AURKB1.41403106
35LATS21.38963705
36EPHA21.33722292
37TAF11.31878896
38ATR1.25435155
39MST41.21166236
40WNK31.19395768
41TGFBR11.18788118
42TRIB31.18552014
43TAOK21.17200611
44BRSK11.12682913
45ZAK1.12433778
46MAP3K81.12115402
47PKN21.08900965
48AURKA1.08241309
49CAMK1G1.07165141
50NME11.06956965
51PDK21.05189329
52PASK1.05149606
53PAK41.04831068
54MAPKAPK31.03743137
55TRIM281.00665004
56PIM10.98818982
57MAP3K110.98779586
58CDK80.94444703
59MAP4K10.93910023
60CDK190.92812900
61VRK10.91945595
62CHEK10.90292860
63CAMK1D0.89127537
64TESK20.88515715
65BCKDK0.88006388
66CDK30.83493657
67EIF2AK20.83438799
68BMPR1B0.83354900
69PLK20.81292685
70PLK30.79212848
71SMG10.78876705
72MAP3K40.78741611
73PIM20.78261283
74CSNK1G30.77540069
75STK100.77403212
76WNK40.76421835
77SCYL20.75485464
78BLK0.73810516
79CDK20.72236255
80PRKCI0.70938527
81MAP2K30.70888177
82FRK0.69806478
83AKT20.69785106
84KDR0.69059952
85MTOR0.68219692
86CSNK1A1L0.66752734
87CSNK1G10.66562502
88FLT30.64965889
89ALK0.64079520
90STK38L0.63632549
91BRAF0.63586278
92ERBB40.63256879
93BRD40.63106834
94AKT30.61302529
95ZAP700.60177668
96RAF10.59966123
97LRRK20.58017738
98DYRK20.55264772
99MUSK0.54207325
100PRKDC0.54137176
101MET0.53438270
102MAP2K70.53367747
103CSNK2A10.52968632
104PAK10.52775191
105STK40.50744959
106RPS6KA50.50629669
107ATM0.50357169
108CDK60.49529395
109CSNK2A20.49361885
110ERN10.47078289
111DAPK10.46432667
112MAPK110.45150718
113EIF2AK30.45120768
114TTN0.44804619
115ERBB30.44543840
116CSNK1G20.44397923
117ICK0.43842075
118STK30.42916560
119STK390.42258856
120CDK90.42237491
121BCR0.41437775
122CDK10.41307523
123IRAK20.40119797
124YES10.39125579
125GRK60.38932708
126CLK10.37497648
127GRK10.37089060
128BTK0.36369745
129ILK0.34710583
130MATK0.34696580
131MAPK140.34542790
132MAP2K20.34397385
133MST1R0.33045926
134RPS6KA10.30453475
135TYK20.29207823
136PAK20.28549790
137MAPKAPK50.27557404
138GSK3B0.26645749
139AKT10.26255972
140CDK11A0.26043364
141DYRK1B0.25976780
142IRAK30.25902905
143CSNK1E0.25605341
144NLK0.21314007

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.27183158
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.63508338
3Ribosome_Homo sapiens_hsa030103.46376909
4Mismatch repair_Homo sapiens_hsa034303.43331747
5Spliceosome_Homo sapiens_hsa030403.38748967
6Base excision repair_Homo sapiens_hsa034103.30588853
7RNA transport_Homo sapiens_hsa030133.27771235
8RNA polymerase_Homo sapiens_hsa030203.14925124
9* Cell cycle_Homo sapiens_hsa041102.69502495
10Homologous recombination_Homo sapiens_hsa034402.57910961
11Proteasome_Homo sapiens_hsa030502.46822260
12Nucleotide excision repair_Homo sapiens_hsa034202.42886408
13Pyrimidine metabolism_Homo sapiens_hsa002402.35244426
14One carbon pool by folate_Homo sapiens_hsa006702.31772040
15Vitamin B6 metabolism_Homo sapiens_hsa007502.20332384
16Fanconi anemia pathway_Homo sapiens_hsa034602.14254336
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97553094
18mRNA surveillance pathway_Homo sapiens_hsa030151.81638518
19p53 signaling pathway_Homo sapiens_hsa041151.75333673
20Basal transcription factors_Homo sapiens_hsa030221.65116670
21RNA degradation_Homo sapiens_hsa030181.63015113
22Sulfur relay system_Homo sapiens_hsa041221.52535706
23Propanoate metabolism_Homo sapiens_hsa006401.52317487
24Folate biosynthesis_Homo sapiens_hsa007901.49408524
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44118765
26Pyruvate metabolism_Homo sapiens_hsa006201.42774433
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34712684
28Protein export_Homo sapiens_hsa030601.32563954
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30735579
30Biosynthesis of amino acids_Homo sapiens_hsa012301.25990358
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.21588880
32Parkinsons disease_Homo sapiens_hsa050121.17619088
33Purine metabolism_Homo sapiens_hsa002301.16688697
34Epstein-Barr virus infection_Homo sapiens_hsa051691.14974721
35* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14430638
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.12575425
37Pentose phosphate pathway_Homo sapiens_hsa000301.12407224
38Huntingtons disease_Homo sapiens_hsa050161.11170230
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09708328
40Steroid biosynthesis_Homo sapiens_hsa001001.08808171
41Oxidative phosphorylation_Homo sapiens_hsa001901.06644273
42Fatty acid elongation_Homo sapiens_hsa000621.06199833
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.03829735
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02263657
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.99722457
46Non-homologous end-joining_Homo sapiens_hsa034500.99055997
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94311843
48Herpes simplex infection_Homo sapiens_hsa051680.90197614
49* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88855478
50Selenocompound metabolism_Homo sapiens_hsa004500.87958293
51Notch signaling pathway_Homo sapiens_hsa043300.84282916
52Phototransduction_Homo sapiens_hsa047440.83954121
53Viral carcinogenesis_Homo sapiens_hsa052030.82885771
54Fatty acid metabolism_Homo sapiens_hsa012120.78835442
55* HTLV-I infection_Homo sapiens_hsa051660.78011564
56* Oocyte meiosis_Homo sapiens_hsa041140.73691288
57Regulation of autophagy_Homo sapiens_hsa041400.73491560
58Systemic lupus erythematosus_Homo sapiens_hsa053220.73051253
59Fructose and mannose metabolism_Homo sapiens_hsa000510.72489200
60Primary immunodeficiency_Homo sapiens_hsa053400.71303912
61MicroRNAs in cancer_Homo sapiens_hsa052060.71287650
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71157006
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68758882
64Small cell lung cancer_Homo sapiens_hsa052220.66358886
65Thyroid cancer_Homo sapiens_hsa052160.66214694
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66099354
67Basal cell carcinoma_Homo sapiens_hsa052170.65336108
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64756714
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63955320
70Bladder cancer_Homo sapiens_hsa052190.63927697
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62345291
72Antigen processing and presentation_Homo sapiens_hsa046120.61508774
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61491201
74Chronic myeloid leukemia_Homo sapiens_hsa052200.60679140
75Carbon metabolism_Homo sapiens_hsa012000.60000275
76Hippo signaling pathway_Homo sapiens_hsa043900.57689339
77Butanoate metabolism_Homo sapiens_hsa006500.54861874
78Acute myeloid leukemia_Homo sapiens_hsa052210.54418297
79Apoptosis_Homo sapiens_hsa042100.53473765
80Alzheimers disease_Homo sapiens_hsa050100.52932407
81Galactose metabolism_Homo sapiens_hsa000520.52862293
82Arginine and proline metabolism_Homo sapiens_hsa003300.51212892
83Measles_Homo sapiens_hsa051620.50817453
84Lysine degradation_Homo sapiens_hsa003100.49463468
85Hedgehog signaling pathway_Homo sapiens_hsa043400.45869018
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.39101718
87Peroxisome_Homo sapiens_hsa041460.38514546
88mTOR signaling pathway_Homo sapiens_hsa041500.37965286
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35981384
90Hepatitis B_Homo sapiens_hsa051610.35459791
91Vitamin digestion and absorption_Homo sapiens_hsa049770.35105961
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34902977
93HIF-1 signaling pathway_Homo sapiens_hsa040660.34440063
94Colorectal cancer_Homo sapiens_hsa052100.34094701
95Alcoholism_Homo sapiens_hsa050340.34009644
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.30977475
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29680212
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29113486
99Other glycan degradation_Homo sapiens_hsa005110.27975251
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.27294746
101Legionellosis_Homo sapiens_hsa051340.27131900
102N-Glycan biosynthesis_Homo sapiens_hsa005100.26402305
103Taste transduction_Homo sapiens_hsa047420.25903362
104Pathways in cancer_Homo sapiens_hsa052000.25481405
105Non-small cell lung cancer_Homo sapiens_hsa052230.25114855
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25062574
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25008791
108Fatty acid biosynthesis_Homo sapiens_hsa000610.24707210
109Fatty acid degradation_Homo sapiens_hsa000710.23268155
110beta-Alanine metabolism_Homo sapiens_hsa004100.22185146
111FoxO signaling pathway_Homo sapiens_hsa040680.22092248
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22075054
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21493244
114Influenza A_Homo sapiens_hsa051640.21431353
115Glutathione metabolism_Homo sapiens_hsa004800.20161323
116Metabolic pathways_Homo sapiens_hsa011000.19881818
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.19791357
118Viral myocarditis_Homo sapiens_hsa054160.19456760
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17729631
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.16742691
121Shigellosis_Homo sapiens_hsa051310.16383295
122Melanoma_Homo sapiens_hsa052180.15382417
123Wnt signaling pathway_Homo sapiens_hsa043100.15189739
124Endometrial cancer_Homo sapiens_hsa052130.14934415
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14820399
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14641104
127Cardiac muscle contraction_Homo sapiens_hsa042600.12980968
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12747129
129Ether lipid metabolism_Homo sapiens_hsa005650.11061661
130Nicotine addiction_Homo sapiens_hsa050330.08324804
131TGF-beta signaling pathway_Homo sapiens_hsa043500.07375188
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.04653739
133Tight junction_Homo sapiens_hsa045300.03008269
134Sphingolipid metabolism_Homo sapiens_hsa006000.02758828
135Glucagon signaling pathway_Homo sapiens_hsa049220.02586404
136Arginine biosynthesis_Homo sapiens_hsa002200.02217316

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