ANAPC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)5.47257059
2detection of light stimulus involved in visual perception (GO:0050908)5.47257059
3rRNA catabolic process (GO:0016075)5.10984003
4fucose catabolic process (GO:0019317)4.91985304
5L-fucose metabolic process (GO:0042354)4.91985304
6L-fucose catabolic process (GO:0042355)4.91985304
7RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)4.75457513
8establishment of protein localization to Golgi (GO:0072600)4.71483453
9regulation of cilium movement (GO:0003352)4.62680779
10cAMP catabolic process (GO:0006198)4.51826751
11protein targeting to Golgi (GO:0000042)4.41413386
12cyclic nucleotide catabolic process (GO:0009214)4.24207708
13protein polyglutamylation (GO:0018095)4.15275279
14protein localization to Golgi apparatus (GO:0034067)3.94900638
15respiratory chain complex IV assembly (GO:0008535)3.90170862
16piRNA metabolic process (GO:0034587)3.88488193
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.76595827
18retrograde transport, vesicle recycling within Golgi (GO:0000301)3.72725617
19kynurenine metabolic process (GO:0070189)3.60658305
20epithelial cilium movement (GO:0003351)3.54193901
21cellular ketone body metabolic process (GO:0046950)3.49115107
22axoneme assembly (GO:0035082)3.48958350
23inositol phosphate catabolic process (GO:0071545)3.42120172
24DNA deamination (GO:0045006)3.41696422
25response to pheromone (GO:0019236)3.41571874
26ketone body metabolic process (GO:1902224)3.37165616
27regulation of hexokinase activity (GO:1903299)3.36498538
28regulation of glucokinase activity (GO:0033131)3.36498538
29indole-containing compound catabolic process (GO:0042436)3.35347512
30indolalkylamine catabolic process (GO:0046218)3.35347512
31tryptophan catabolic process (GO:0006569)3.35347512
32mannosylation (GO:0097502)3.34466988
33neural tube formation (GO:0001841)3.21588667
34cytochrome complex assembly (GO:0017004)3.20858023
35acrosome reaction (GO:0007340)3.20613138
36cellular response to ATP (GO:0071318)3.20485999
37inositol phosphate dephosphorylation (GO:0046855)3.17744603
38phosphorylated carbohydrate dephosphorylation (GO:0046838)3.17744603
39protein K6-linked ubiquitination (GO:0085020)3.14736428
40ncRNA catabolic process (GO:0034661)3.13769671
41tryptophan metabolic process (GO:0006568)3.13234279
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09035660
43indolalkylamine metabolic process (GO:0006586)3.08286656
44regulation of meiosis I (GO:0060631)3.07463048
45protein prenylation (GO:0018342)3.05503423
46prenylation (GO:0097354)3.05503423
47behavioral response to nicotine (GO:0035095)3.05353131
48retinal cone cell development (GO:0046549)3.01211776
49cell wall macromolecule catabolic process (GO:0016998)3.00703796
50ubiquinone biosynthetic process (GO:0006744)2.98739663
51multicellular organism reproduction (GO:0032504)2.95828690
52exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93213555
53regulation of microtubule-based movement (GO:0060632)2.92912312
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92834831
55sperm motility (GO:0030317)2.90575864
56maturation of 5.8S rRNA (GO:0000460)2.89619899
57preassembly of GPI anchor in ER membrane (GO:0016254)2.88578515
58cilium morphogenesis (GO:0060271)2.87877236
59cell wall macromolecule metabolic process (GO:0044036)2.86489882
60seminiferous tubule development (GO:0072520)2.86288413
61regulation of protein kinase A signaling (GO:0010738)2.84562604
62intraciliary transport (GO:0042073)2.82171734
63adenosine metabolic process (GO:0046085)2.81451129
64polyol catabolic process (GO:0046174)2.80206643
65cilium movement (GO:0003341)2.79085267
66DNA methylation involved in gamete generation (GO:0043046)2.76827085
67cGMP metabolic process (GO:0046068)2.75127887
68ubiquinone metabolic process (GO:0006743)2.74404267
69photoreceptor cell maintenance (GO:0045494)2.73928702
70intra-Golgi vesicle-mediated transport (GO:0006891)2.72903969
71sphingosine metabolic process (GO:0006670)2.70121181
72protein localization to cilium (GO:0061512)2.66929651
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66795451
74nonmotile primary cilium assembly (GO:0035058)2.66082387
75base-excision repair, AP site formation (GO:0006285)2.62629393
76protein complex biogenesis (GO:0070271)2.62169826
77cilium or flagellum-dependent cell motility (GO:0001539)2.60333119
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59942227
79mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.59194224
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.59194224
81NADH dehydrogenase complex assembly (GO:0010257)2.59194224
82positive regulation of mitochondrial fission (GO:0090141)2.58496589
83sphingoid metabolic process (GO:0046519)2.56934735
84double-strand break repair via homologous recombination (GO:0000724)2.55040737
85centriole replication (GO:0007099)2.54657195
86recombinational repair (GO:0000725)2.54511701
87male meiosis I (GO:0007141)2.54356225
88DNA demethylation (GO:0080111)2.53611528
89DNA double-strand break processing (GO:0000729)2.51903946
90diol metabolic process (GO:0034311)2.51670131
91cilium organization (GO:0044782)2.51411322
92regulation of transmission of nerve impulse (GO:0051969)2.50775833
93protein-cofactor linkage (GO:0018065)2.50463757
94water-soluble vitamin biosynthetic process (GO:0042364)2.47544671
95brain morphogenesis (GO:0048854)2.47328527
96calcium ion import (GO:0070509)2.45961522
97regulation of collateral sprouting (GO:0048670)2.45675654
98GPI anchor metabolic process (GO:0006505)2.45671289
99RNA phosphodiester bond hydrolysis (GO:0090501)2.45248114
100keratinocyte development (GO:0003334)2.44702152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.60593954
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32901199
3VDR_22108803_ChIP-Seq_LS180_Human3.28747758
4GBX2_23144817_ChIP-Seq_PC3_Human2.88531434
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.70428104
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.68737027
7IGF1R_20145208_ChIP-Seq_DFB_Human2.54657153
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46036113
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.35229772
10FUS_26573619_Chip-Seq_HEK293_Human2.20282575
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.16151157
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15051977
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12461813
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12431704
15P300_19829295_ChIP-Seq_ESCs_Human2.08354885
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.00534148
17TAF15_26573619_Chip-Seq_HEK293_Human1.99828343
18EWS_26573619_Chip-Seq_HEK293_Human1.95033585
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94675900
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.93975260
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87934184
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84110306
23CBP_20019798_ChIP-Seq_JUKART_Human1.83633121
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83633121
25IRF1_19129219_ChIP-ChIP_H3396_Human1.83568427
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74963144
27ER_23166858_ChIP-Seq_MCF-7_Human1.72109487
28TP53_22573176_ChIP-Seq_HFKS_Human1.71405361
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64936315
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63447616
31VDR_23849224_ChIP-Seq_CD4+_Human1.56870753
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50558684
33SMAD4_21799915_ChIP-Seq_A2780_Human1.49182087
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48590107
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.46689092
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45417839
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45234932
38EZH2_22144423_ChIP-Seq_EOC_Human1.43436441
39STAT3_23295773_ChIP-Seq_U87_Human1.43302308
40AR_25329375_ChIP-Seq_VCAP_Human1.43292370
41SOX2_19829295_ChIP-Seq_ESCs_Human1.40950898
42NANOG_19829295_ChIP-Seq_ESCs_Human1.40950898
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.38421581
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.38146010
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37819487
46ELK1_19687146_ChIP-ChIP_HELA_Human1.37557112
47TCF4_23295773_ChIP-Seq_U87_Human1.37017235
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.36440826
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.35915189
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33482372
51TCF4_22108803_ChIP-Seq_LS180_Human1.30817428
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28444853
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28106419
54BCAT_22108803_ChIP-Seq_LS180_Human1.27404960
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27198094
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.25919588
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.25227553
58P53_22387025_ChIP-Seq_ESCs_Mouse1.24329993
59SMAD4_21741376_ChIP-Seq_EPCs_Human1.23982215
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23134808
61FLI1_21867929_ChIP-Seq_TH2_Mouse1.22076798
62RUNX2_22187159_ChIP-Seq_PCA_Human1.21306447
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19798617
64AR_21572438_ChIP-Seq_LNCaP_Human1.19227560
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.16939922
66E2F1_18555785_Chip-Seq_ESCs_Mouse1.16807733
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16653064
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16207531
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15999203
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15169897
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.14785336
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14785336
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14557490
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14557490
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.13980925
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12524237
77NCOR_22424771_ChIP-Seq_293T_Human1.12339051
78CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11645052
79AR_20517297_ChIP-Seq_VCAP_Human1.11446436
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11199154
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09616894
82HOXB7_26014856_ChIP-Seq_BT474_Human1.09476046
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09161549
84REST_21632747_ChIP-Seq_MESCs_Mouse1.08112629
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.07963496
86MYC_18940864_ChIP-ChIP_HL60_Human1.07927336
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07560825
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.07092393
89CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07021579
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06468886
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.05752786
92GATA3_26560356_Chip-Seq_TH2_Human1.04304277
93P300_18555785_Chip-Seq_ESCs_Mouse1.03888007
94AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02480433
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02162942
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01754375
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01596312
98CDX2_22108803_ChIP-Seq_LS180_Human0.98794849
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98742075
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98660558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.56579072
2MP0002102_abnormal_ear_morphology3.17836227
3MP0005551_abnormal_eye_electrophysiolog2.90200477
4MP0003195_calcinosis2.77830736
5MP0008058_abnormal_DNA_repair2.44508524
6MP0004142_abnormal_muscle_tone2.41119668
7MP0002876_abnormal_thyroid_physiology2.26422412
8MP0008875_abnormal_xenobiotic_pharmacok2.22153979
9MP0005253_abnormal_eye_physiology2.16215233
10MP0003787_abnormal_imprinting2.16148800
11MP0003880_abnormal_central_pattern2.08318413
12MP0006292_abnormal_olfactory_placode2.07527192
13MP0001529_abnormal_vocalization2.00553157
14MP0001968_abnormal_touch/_nociception2.00088136
15MP0009046_muscle_twitch1.96402613
16MP0006072_abnormal_retinal_apoptosis1.91786420
17MP0002837_dystrophic_cardiac_calcinosis1.90607754
18MP0003718_maternal_effect1.88862887
19MP0005645_abnormal_hypothalamus_physiol1.85049348
20MP0008872_abnormal_physiological_respon1.84773096
21MP0001501_abnormal_sleep_pattern1.76754125
22MP0003646_muscle_fatigue1.67564820
23MP0005410_abnormal_fertilization1.66062133
24MP0000372_irregular_coat_pigmentation1.64611025
25MP0004147_increased_porphyrin_level1.64536499
26MP0006276_abnormal_autonomic_nervous1.63116950
27MP0002736_abnormal_nociception_after1.59633715
28MP0001984_abnormal_olfaction1.58060601
29MP0001986_abnormal_taste_sensitivity1.55528937
30MP0004043_abnormal_pH_regulation1.54927413
31MP0002638_abnormal_pupillary_reflex1.51960509
32MP0001764_abnormal_homeostasis1.46613804
33MP0001486_abnormal_startle_reflex1.44132349
34MP0006082_CNS_inflammation1.41610516
35MP0002272_abnormal_nervous_system1.37774050
36MP0005646_abnormal_pituitary_gland1.36814820
37MP0002572_abnormal_emotion/affect_behav1.36638250
38MP0004924_abnormal_behavior1.30793643
39MP0005386_behavior/neurological_phenoty1.30793643
40MP0005360_urolithiasis1.28253754
41MP0009745_abnormal_behavioral_response1.26467643
42MP0004885_abnormal_endolymph1.25243177
43MP0000569_abnormal_digit_pigmentation1.22143297
44MP0005075_abnormal_melanosome_morpholog1.22113226
45MP0000631_abnormal_neuroendocrine_gland1.20588691
46MP0006036_abnormal_mitochondrial_physio1.15584237
47MP0000427_abnormal_hair_cycle1.15232462
48MP0004133_heterotaxia1.14473930
49MP0002138_abnormal_hepatobiliary_system1.14143462
50MP0004145_abnormal_muscle_electrophysio1.13572456
51MP0001970_abnormal_pain_threshold1.13002157
52MP0001929_abnormal_gametogenesis1.11448401
53MP0002733_abnormal_thermal_nociception1.11289246
54MP0002557_abnormal_social/conspecific_i1.11251956
55MP0002734_abnormal_mechanical_nocicepti1.10697395
56MP0003698_abnormal_male_reproductive1.09602423
57MP0008775_abnormal_heart_ventricle1.08844626
58MP0004484_altered_response_of1.07541592
59MP0005195_abnormal_posterior_eye1.06773209
60MP0009764_decreased_sensitivity_to1.06651792
61MP0003950_abnormal_plasma_membrane1.04399547
62MP0004215_abnormal_myocardial_fiber1.04361142
63MP0002090_abnormal_vision1.03408315
64MP0008057_abnormal_DNA_replication1.00978986
65MP0001835_abnormal_antigen_presentation1.00592026
66MP0005636_abnormal_mineral_homeostasis0.99792391
67MP0006035_abnormal_mitochondrial_morpho0.97969662
68MP0002229_neurodegeneration0.97899604
69MP0002064_seizures0.96883215
70MP0002184_abnormal_innervation0.96419728
71MP0001905_abnormal_dopamine_level0.95991776
72MP0000647_abnormal_sebaceous_gland0.95261211
73MP0002735_abnormal_chemical_nociception0.95206615
74MP0002928_abnormal_bile_duct0.93984901
75MP0008789_abnormal_olfactory_epithelium0.93427924
76MP0005084_abnormal_gallbladder_morpholo0.93219213
77MP0003121_genomic_imprinting0.92454354
78MP0002751_abnormal_autonomic_nervous0.89775534
79MP0005379_endocrine/exocrine_gland_phen0.88311899
80MP0005389_reproductive_system_phenotype0.88166860
81MP0002067_abnormal_sensory_capabilities0.87480050
82MP0001485_abnormal_pinna_reflex0.86729057
83MP0005377_hearing/vestibular/ear_phenot0.85868708
84MP0003878_abnormal_ear_physiology0.85868708
85MP0003186_abnormal_redox_activity0.85456976
86MP0001765_abnormal_ion_homeostasis0.85212311
87MP0005332_abnormal_amino_acid0.84342813
88MP0010094_abnormal_chromosome_stability0.84255482
89MP0002752_abnormal_somatic_nervous0.83886407
90MP0009697_abnormal_copulation0.82556212
91MP0002063_abnormal_learning/memory/cond0.81908821
92MP0003252_abnormal_bile_duct0.81370998
93MP0005408_hypopigmentation0.80997885
94MP0003786_premature_aging0.78709041
95MP0002938_white_spotting0.78060854
96MP0001963_abnormal_hearing_physiology0.77962439
97MP0005391_vision/eye_phenotype0.77621337
98MP0002210_abnormal_sex_determination0.77507046
99MP0002234_abnormal_pharynx_morphology0.76813908
100MP0005671_abnormal_response_to0.76342837

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.01132746
2Abnormal rod and cone electroretinograms (HP:0008323)5.07117260
3Hypoplasia of the fovea (HP:0007750)4.60757133
4Aplasia/Hypoplasia of the fovea (HP:0008060)4.60757133
5Severe visual impairment (HP:0001141)4.57512663
6Abnormality of macular pigmentation (HP:0008002)4.01734947
7Abnormality of the fovea (HP:0000493)3.79204388
8Central scotoma (HP:0000603)3.62505648
9Molar tooth sign on MRI (HP:0002419)3.61906294
10Abnormality of midbrain morphology (HP:0002418)3.61906294
11Renal cortical cysts (HP:0000803)3.56277328
12Abnormality of the renal cortex (HP:0011035)3.41910953
13Pancreatic cysts (HP:0001737)3.33522147
14Nephronophthisis (HP:0000090)3.03914823
15Chronic hepatic failure (HP:0100626)2.98481459
16Attenuation of retinal blood vessels (HP:0007843)2.96702922
17Aplasia/Hypoplasia of the macula (HP:0008059)2.95634749
18Pancreatic fibrosis (HP:0100732)2.93632546
19True hermaphroditism (HP:0010459)2.86168241
20Decreased central vision (HP:0007663)2.85226965
21Medial flaring of the eyebrow (HP:0010747)2.78277357
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.77751391
23Aplasia/Hypoplasia affecting the retina (HP:0008061)2.76003422
24Abnormality of the renal medulla (HP:0100957)2.75985256
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.74030712
26Albinism (HP:0001022)2.67235389
27Type II lissencephaly (HP:0007260)2.64459719
28Tubulointerstitial nephritis (HP:0001970)2.63361187
29Abolished electroretinogram (ERG) (HP:0000550)2.52713490
30Hepatic necrosis (HP:0002605)2.46383079
31Constricted visual fields (HP:0001133)2.45706778
32Scotoma (HP:0000575)2.39481608
33Stomatitis (HP:0010280)2.37470840
34Hypochromic microcytic anemia (HP:0004840)2.31442492
35Hypoproteinemia (HP:0003075)2.31033426
36Inability to walk (HP:0002540)2.27090755
37Hepatocellular necrosis (HP:0001404)2.26189108
38Increased CSF lactate (HP:0002490)2.26161436
39Tubular atrophy (HP:0000092)2.25715456
40Optic nerve hypoplasia (HP:0000609)2.25585896
41Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.25454969
42Acute necrotizing encephalopathy (HP:0006965)2.23149693
43Congenital primary aphakia (HP:0007707)2.21939712
44Mitochondrial inheritance (HP:0001427)2.21642860
45Gait imbalance (HP:0002141)2.21288950
46Stomach cancer (HP:0012126)2.21169841
47Abnormality of DNA repair (HP:0003254)2.17087722
48Progressive macrocephaly (HP:0004481)2.16462192
49Colon cancer (HP:0003003)2.15524118
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14980793
51Progressive inability to walk (HP:0002505)2.13259377
523-Methylglutaconic aciduria (HP:0003535)2.10116081
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.08878992
54Polydipsia (HP:0001959)2.08421504
55Abnormal drinking behavior (HP:0030082)2.08421504
56Keratoconus (HP:0000563)2.07260508
57Increased corneal curvature (HP:0100692)2.07260508
58Cerebellar dysplasia (HP:0007033)2.03680338
59Type I transferrin isoform profile (HP:0003642)2.01694151
60Cystic liver disease (HP:0006706)2.00909197
61Abnormal biliary tract physiology (HP:0012439)2.00568020
62Bile duct proliferation (HP:0001408)2.00568020
63Abnormality of alanine metabolism (HP:0010916)1.99516318
64Hyperalaninemia (HP:0003348)1.99516318
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99516318
66Methylmalonic acidemia (HP:0002912)1.99247003
67Nephrogenic diabetes insipidus (HP:0009806)1.99045602
68Fair hair (HP:0002286)1.98799610
69Optic disc pallor (HP:0000543)1.98459083
70Abnormal protein glycosylation (HP:0012346)1.96167775
71Abnormal glycosylation (HP:0012345)1.96167775
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96167775
73Abnormal protein N-linked glycosylation (HP:0012347)1.96167775
74Ketosis (HP:0001946)1.95995556
75Abnormal mitochondria in muscle tissue (HP:0008316)1.95867100
76Hyperventilation (HP:0002883)1.91826561
77Bony spicule pigmentary retinopathy (HP:0007737)1.89096185
78Acute encephalopathy (HP:0006846)1.88499553
79Protruding tongue (HP:0010808)1.87783465
80Absent speech (HP:0001344)1.86477539
81Lissencephaly (HP:0001339)1.84325378
82Increased serum lactate (HP:0002151)1.83346074
83Intestinal atresia (HP:0011100)1.80701656
84Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79420995
85Hyperglycinuria (HP:0003108)1.79096456
86Broad-based gait (HP:0002136)1.78031148
87Astigmatism (HP:0000483)1.76465663
88Absent/shortened dynein arms (HP:0200106)1.75971411
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.75971411
90Congenital hepatic fibrosis (HP:0002612)1.75110215
91Lipid accumulation in hepatocytes (HP:0006561)1.74760071
92Poor head control (HP:0002421)1.73621701
93Short tibia (HP:0005736)1.71320943
94Pendular nystagmus (HP:0012043)1.69880745
95Polyuria (HP:0000103)1.69038196
96Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68668226
97Tubulointerstitial abnormality (HP:0001969)1.67837385
98Postaxial foot polydactyly (HP:0001830)1.67786513
99CNS demyelination (HP:0007305)1.67353300
100Pachygyria (HP:0001302)1.66767694

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34962599
2MAP4K23.23820413
3ADRBK22.78937920
4BRD42.65530275
5WNK32.47758007
6TAOK32.30048780
7WNK42.21583720
8BMPR1B2.18868820
9TRIM282.13538309
10BCR2.13312460
11CASK2.12090151
12PINK12.10633947
13NUAK12.06783092
14TNIK2.03656157
15MAP3K42.02920530
16CSNK1G31.93510242
17ZAK1.92301286
18CSNK1A1L1.86757193
19GRK11.84976955
20CDK191.70689726
21OXSR11.66885509
22ERBB31.61920650
23CSNK1G11.60792532
24MST41.55666024
25CSNK1G21.49803224
26STK38L1.43338491
27TLK11.42315983
28BMPR21.36869771
29PNCK1.29394350
30EIF2AK31.28855605
31VRK11.28583940
32DAPK21.26163558
33EPHA41.25901512
34PAK31.21864169
35BCKDK1.10855516
36MAPK131.08881334
37BLK1.05881322
38INSRR1.02915228
39TXK0.98480974
40STK390.93031381
41TRPM70.92662136
42TEC0.92188143
43PLK40.91292779
44MAP2K70.90203361
45MARK10.86356388
46SRPK10.84908250
47PTK2B0.84899302
48VRK20.83619601
49PRKCE0.83386272
50PLK20.82946742
51IKBKB0.79117370
52ACVR1B0.78354910
53DAPK10.78157040
54MKNK20.77647825
55DYRK20.75298845
56ATR0.72064218
57RPS6KA40.71421903
58PLK30.64695792
59PRKCG0.61114457
60KIT0.60913218
61CSF1R0.59167450
62CDK30.57721139
63CSNK1A10.57210551
64MARK30.56853276
65MAPKAPK30.56476297
66GRK60.55658270
67NTRK30.54635518
68ADRBK10.54355795
69ITK0.53840565
70CAMKK20.53143320
71CAMK2A0.49525767
72TIE10.46387538
73PRKACA0.46054379
74MKNK10.45798811
75RPS6KA50.43625914
76CSNK1D0.43215673
77PIK3CG0.43157734
78LYN0.43014686
79PHKG10.41905333
80PHKG20.41905333
81ABL10.41855495
82CAMK10.41243291
83CHUK0.41177093
84TGFBR10.39568476
85PLK10.37389538
86MUSK0.34777186
87PRKG10.34191304
88FLT30.34142074
89MINK10.33461334
90PRKCA0.33032450
91MET0.32924836
92FER0.32175955
93SYK0.31977396
94ATM0.31897402
95FES0.31042857
96IGF1R0.30164796
97NME10.29926188
98GRK50.29490599
99PDK20.29473061
100PRKAA10.29002511

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.17420706
2Phototransduction_Homo sapiens_hsa047442.91585733
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.51902244
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.43085681
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42052955
6Protein export_Homo sapiens_hsa030602.31991545
7Allograft rejection_Homo sapiens_hsa053302.20620913
8Type I diabetes mellitus_Homo sapiens_hsa049402.19204810
9Autoimmune thyroid disease_Homo sapiens_hsa053202.16135881
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14213762
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06395593
12Nitrogen metabolism_Homo sapiens_hsa009102.03756403
13Graft-versus-host disease_Homo sapiens_hsa053321.98881972
14Linoleic acid metabolism_Homo sapiens_hsa005911.93244080
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92972518
16Butanoate metabolism_Homo sapiens_hsa006501.92138210
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91398616
18RNA degradation_Homo sapiens_hsa030181.83750132
19Propanoate metabolism_Homo sapiens_hsa006401.78358403
20Fanconi anemia pathway_Homo sapiens_hsa034601.77481012
21Oxidative phosphorylation_Homo sapiens_hsa001901.72379752
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65862801
23Proteasome_Homo sapiens_hsa030501.62107878
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49814030
25Ether lipid metabolism_Homo sapiens_hsa005651.48093463
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44892431
27Morphine addiction_Homo sapiens_hsa050321.41276055
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40333894
29Homologous recombination_Homo sapiens_hsa034401.40188834
30Tryptophan metabolism_Homo sapiens_hsa003801.39149503
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37663220
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.37243419
33beta-Alanine metabolism_Homo sapiens_hsa004101.32134153
34Steroid biosynthesis_Homo sapiens_hsa001001.28677380
35Regulation of autophagy_Homo sapiens_hsa041401.25821385
36Nicotine addiction_Homo sapiens_hsa050331.21098198
37Selenocompound metabolism_Homo sapiens_hsa004501.18930087
38GABAergic synapse_Homo sapiens_hsa047271.14988422
39Basal transcription factors_Homo sapiens_hsa030221.11311807
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10749497
41Peroxisome_Homo sapiens_hsa041461.09472788
42Olfactory transduction_Homo sapiens_hsa047401.09438922
43Taste transduction_Homo sapiens_hsa047421.06670507
44RNA polymerase_Homo sapiens_hsa030201.05792846
45Parkinsons disease_Homo sapiens_hsa050121.03992359
46RNA transport_Homo sapiens_hsa030131.02869853
47One carbon pool by folate_Homo sapiens_hsa006701.01215580
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.99819262
49Rheumatoid arthritis_Homo sapiens_hsa053230.94793973
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94344084
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92661066
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.92244568
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89539183
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84044574
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83989331
56Arachidonic acid metabolism_Homo sapiens_hsa005900.81309728
57Serotonergic synapse_Homo sapiens_hsa047260.80992281
58Alzheimers disease_Homo sapiens_hsa050100.77770535
59Caffeine metabolism_Homo sapiens_hsa002320.77207020
60Cardiac muscle contraction_Homo sapiens_hsa042600.76522341
61Non-homologous end-joining_Homo sapiens_hsa034500.76466248
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74729774
63Purine metabolism_Homo sapiens_hsa002300.73652447
64Sphingolipid metabolism_Homo sapiens_hsa006000.72784824
65Huntingtons disease_Homo sapiens_hsa050160.71607203
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71101847
67Fatty acid elongation_Homo sapiens_hsa000620.70024200
68Collecting duct acid secretion_Homo sapiens_hsa049660.68877129
69Fat digestion and absorption_Homo sapiens_hsa049750.67594345
70Circadian entrainment_Homo sapiens_hsa047130.66407717
71Insulin secretion_Homo sapiens_hsa049110.64817817
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64336063
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59614916
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58840206
75Antigen processing and presentation_Homo sapiens_hsa046120.58362310
76Metabolic pathways_Homo sapiens_hsa011000.57879302
77Fatty acid metabolism_Homo sapiens_hsa012120.55234462
78Lysine degradation_Homo sapiens_hsa003100.53646460
79Viral myocarditis_Homo sapiens_hsa054160.50850799
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.50787772
81Nucleotide excision repair_Homo sapiens_hsa034200.50123656
82Histidine metabolism_Homo sapiens_hsa003400.48660095
83Renin secretion_Homo sapiens_hsa049240.48598848
84Chemical carcinogenesis_Homo sapiens_hsa052040.47398598
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46856231
86Salivary secretion_Homo sapiens_hsa049700.46843237
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43977857
88Calcium signaling pathway_Homo sapiens_hsa040200.41465454
89ABC transporters_Homo sapiens_hsa020100.41459047
90Systemic lupus erythematosus_Homo sapiens_hsa053220.40444702
91Fatty acid degradation_Homo sapiens_hsa000710.40411895
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39266035
93Primary immunodeficiency_Homo sapiens_hsa053400.38694078
94Retinol metabolism_Homo sapiens_hsa008300.38044223
95Hematopoietic cell lineage_Homo sapiens_hsa046400.37313594
96Glutamatergic synapse_Homo sapiens_hsa047240.36674490
97Base excision repair_Homo sapiens_hsa034100.36486209
98Dopaminergic synapse_Homo sapiens_hsa047280.34645428
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34338597
100Glycerolipid metabolism_Homo sapiens_hsa005610.33397385

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