AMTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1female mating behavior (GO:0060180)9.13854560
2positive regulation of collagen biosynthetic process (GO:0032967)7.92476961
3positive regulation of collagen metabolic process (GO:0010714)7.54805035
4positive regulation of filopodium assembly (GO:0051491)7.16775942
5regulation of collagen biosynthetic process (GO:0032965)6.98924467
6regulation of collagen metabolic process (GO:0010712)6.08912258
7endodermal cell differentiation (GO:0035987)5.90804058
8negative regulation of T cell differentiation in thymus (GO:0033085)5.87611946
9positive regulation of biomineral tissue development (GO:0070169)5.85026210
10bone trabecula formation (GO:0060346)5.61124766
11positive regulation of multicellular organismal metabolic process (GO:0044253)5.58011661
12extracellular matrix disassembly (GO:0022617)5.32986141
13regulation of biomineral tissue development (GO:0070167)5.26637660
14cell-substrate junction assembly (GO:0007044)5.18355271
15G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.75592017
16multicellular organismal reproductive behavior (GO:0033057)4.66692333
17regulation of multicellular organismal metabolic process (GO:0044246)4.65104052
18chondrocyte differentiation (GO:0002062)4.53276980
19negative regulation of keratinocyte proliferation (GO:0010839)4.46514684
20regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.45337395
21dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.39515765
22regulation of filopodium assembly (GO:0051489)4.38957144
23positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.38365511
24multi-organism reproductive behavior (GO:0044705)4.34276945
25epithelial to mesenchymal transition (GO:0001837)4.32587834
26regulation of transcription from RNA polymerase I promoter (GO:0006356)4.31670154
27C4-dicarboxylate transport (GO:0015740)4.30439146
28reproductive behavior (GO:0019098)4.26304295
29positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003604.20778695
30regulation of female gonad development (GO:2000194)4.16407878
31cellular response to vitamin D (GO:0071305)4.12090373
32positive regulation of osteoblast proliferation (GO:0033690)4.00712261
33ovulation cycle (GO:0042698)3.97340628
34positive regulation of hair cycle (GO:0042635)3.82958845
35positive regulation of hair follicle development (GO:0051798)3.82958845
36mesodermal cell differentiation (GO:0048333)3.72723902
37short-term memory (GO:0007614)3.71277160
38kidney mesenchyme development (GO:0072074)3.69880784
39desmosome organization (GO:0002934)3.62864771
40histamine transport (GO:0051608)3.62196068
41mating behavior (GO:0007617)3.58044237
42collagen catabolic process (GO:0030574)3.57558608
43lateral sprouting from an epithelium (GO:0060601)3.54528261
44somatic stem cell division (GO:0048103)3.53902039
45neuron projection extension involved in neuron projection guidance (GO:1902284)3.48736793
46axon extension involved in axon guidance (GO:0048846)3.48736793
47lateral ventricle development (GO:0021670)3.45913399
48prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.45362853
49collagen metabolic process (GO:0032963)3.45090363
50non-canonical Wnt signaling pathway (GO:0035567)3.43429543
51regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.42793935
52diterpenoid biosynthetic process (GO:0016102)3.42705249
53COPI coating of Golgi vesicle (GO:0048205)3.41314447
54Golgi transport vesicle coating (GO:0048200)3.41314447
55regulation of oxidative stress-induced neuron death (GO:1903203)3.36284340
56regulation of hair follicle development (GO:0051797)3.32081242
57multicellular organismal catabolic process (GO:0044243)3.26884975
58drug transmembrane transport (GO:0006855)3.23028686
59multicellular organismal macromolecule metabolic process (GO:0044259)3.22816298
60righting reflex (GO:0060013)3.20627488
61SMAD protein complex assembly (GO:0007183)3.20613397
62epithelial cell-cell adhesion (GO:0090136)3.17945116
63macroautophagy (GO:0016236)3.12360226
64retinal metabolic process (GO:0042574)3.09432773
65negative regulation of hormone metabolic process (GO:0032351)3.09195759
66chemical homeostasis within a tissue (GO:0048875)3.08581191
67terpenoid biosynthetic process (GO:0016114)3.08286935
68regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.08088096
69renal filtration (GO:0097205)3.07264709
70Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.06141463
71viral entry into host cell (GO:0046718)3.05536666
72regulation of osteoblast proliferation (GO:0033688)3.04809884
73gap junction assembly (GO:0016264)3.03648080
74multicellular organismal metabolic process (GO:0044236)3.02447313
75nerve growth factor signaling pathway (GO:0038180)3.02363869
76inositol phosphate-mediated signaling (GO:0048016)3.01127921
77negative regulation of protein localization to plasma membrane (GO:1903077)3.00843809
78sodium ion export (GO:0071436)3.00557509
79endochondral ossification (GO:0001958)3.00494141
80replacement ossification (GO:0036075)3.00494141
81positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.00043887
82tooth mineralization (GO:0034505)26.4727061
83regulation of organ morphogenesis (GO:2000027)2.99990734
84cranial suture morphogenesis (GO:0060363)2.99925404
85cellular response to vitamin (GO:0071295)2.95649438
86osteoblast differentiation (GO:0001649)2.94631966
87regulation of establishment of planar polarity (GO:0090175)2.93853725
88cell redox homeostasis (GO:0045454)2.93410275
89peripheral nervous system development (GO:0007422)2.91612371
90face development (GO:0060324)2.90497280
91muscle cell migration (GO:0014812)2.89858923
92regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.87638000
93negative regulation of chondrocyte differentiation (GO:0032331)2.86950936
94outer ear morphogenesis (GO:0042473)2.86525503
95regulation of NFAT protein import into nucleus (GO:0051532)2.85273913
96motor neuron axon guidance (GO:0008045)2.84935578
97ganglion development (GO:0061548)2.83668529
98coenzyme A biosynthetic process (GO:0015937)2.82277103
99regulation of lipoprotein metabolic process (GO:0050746)2.82062747
100regulation of keratinocyte proliferation (GO:0010837)2.80231266
101surfactant homeostasis (GO:0043129)2.80215915
102artery development (GO:0060840)2.77899811
103mesenchymal-epithelial cell signaling (GO:0060638)2.77618390
104polarized epithelial cell differentiation (GO:0030859)2.76533764
105negative regulation of Notch signaling pathway (GO:0045746)2.75267280
106azole transport (GO:0045117)2.74693641
107response to vitamin D (GO:0033280)2.74484096
108establishment of planar polarity (GO:0001736)2.73720044
109establishment of tissue polarity (GO:0007164)2.73720044
110craniofacial suture morphogenesis (GO:0097094)2.73255577
111organic cation transport (GO:0015695)2.71140140
112gland morphogenesis (GO:0022612)2.70966182
113response to parathyroid hormone (GO:0071107)2.70730524
114positive regulation of hormone biosynthetic process (GO:0046886)2.70543451
115* organ morphogenesis (GO:0009887)2.70455935
116negative regulation of smooth muscle cell differentiation (GO:0051151)2.69697085
117lung-associated mesenchyme development (GO:0060484)2.67175985
118cell migration involved in sprouting angiogenesis (GO:0002042)2.66813630
119negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.66434837
120branching involved in salivary gland morphogenesis (GO:0060445)2.62925924
121regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.62496714
122positive regulation of extracellular matrix organization (GO:1903055)2.62287937
123chondrocyte development (GO:0002063)2.60900758
124regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60711526
125cardiac right ventricle morphogenesis (GO:0003215)2.60573973
126skeletal muscle fiber development (GO:0048741)2.60413048
127cellular potassium ion homeostasis (GO:0030007)2.59791054
128limb bud formation (GO:0060174)2.59138772
129protein localization to endosome (GO:0036010)2.58518173
130metanephric mesenchyme development (GO:0072075)2.58233113
131regulation of transcription from RNA polymerase III promoter (GO:0006359)2.57959612
132regulation of receptor biosynthetic process (GO:0010869)2.57707038
133localization within membrane (GO:0051668)2.57678566
134regulation of hydrogen peroxide-induced cell death (GO:1903205)2.56867084
135regulation of neuron migration (GO:2001222)2.56158674
136DNA double-strand break processing (GO:0000729)2.54422441
137negative regulation of oxidative stress-induced cell death (GO:1903202)2.53309740
138neuromuscular junction development (GO:0007528)2.49513430
139positive regulation of hormone metabolic process (GO:0032352)2.47137567
140modulation by symbiont of host cellular process (GO:0044068)2.47066150
141iron ion import (GO:0097286)2.46516580
142branching involved in prostate gland morphogenesis (GO:0060442)2.45859219
143cellular copper ion homeostasis (GO:0006878)2.45125481
144cell adhesion mediated by integrin (GO:0033627)2.44877940
145regulation of mesenchymal cell apoptotic process (GO:2001053)2.44869460
146lens fiber cell development (GO:0070307)2.44679924
147cortical cytoskeleton organization (GO:0030865)2.44594552
148midgut development (GO:0007494)2.42297175
149negative regulation of cellular response to oxidative stress (GO:1900408)2.41174904
150negative regulation of response to oxidative stress (GO:1902883)2.41174904
151positive regulation of Rho protein signal transduction (GO:0035025)2.34780365
152regulation of synapse structural plasticity (GO:0051823)2.34519162
153extracellular matrix organization (GO:0030198)2.34140367
154mesenchymal cell proliferation (GO:0010463)2.34086556
155osteoblast development (GO:0002076)2.33702714
156extracellular structure organization (GO:0043062)2.33156997
157hematopoietic stem cell proliferation (GO:0071425)2.31528774
158bundle of His cell to Purkinje myocyte communication (GO:0086069)2.30574139
159lens fiber cell differentiation (GO:0070306)2.28705795
160cell junction organization (GO:0034330)2.23007431
161myotube cell development (GO:0014904)2.22691332
162embryonic hindlimb morphogenesis (GO:0035116)2.19174204
163stem cell division (GO:0017145)2.18748380
164planar cell polarity pathway involved in neural tube closure (GO:0090179)2.18627724
165renal system development (GO:0072001)2.16982517
166leukocyte aggregation (GO:0070486)2.15975425
167negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.13935912
168cell proliferation involved in metanephros development (GO:0072203)2.12196239
169regulation of hair cycle (GO:0042634)2.11213141
170positive regulation of catenin import into nucleus (GO:0035413)2.10739084
171cell surface receptor signaling pathway involved in heart development (GO:0061311)2.10327889
172positive regulation of bone resorption (GO:0045780)2.09497542
173positive regulation of bone remodeling (GO:0046852)2.09497542
174epidermis development (GO:0008544)2.07112516
175positive regulation of osteoblast differentiation (GO:0045669)2.05644247
176adhesion of symbiont to host cell (GO:0044650)2.04942584
177virion attachment to host cell (GO:0019062)2.04942584
178regulation of transforming growth factor beta2 production (GO:0032909)2.02564023
179regulation of superoxide metabolic process (GO:0090322)2.01657876
180cell junction assembly (GO:0034329)2.01562298
181type B pancreatic cell proliferation (GO:0044342)2.01197023
182hemidesmosome assembly (GO:0031581)16.2779974
183* odontogenesis of dentin-containing tooth (GO:0042475)14.8052699
184positive regulation of odontogenesis (GO:0042482)14.6625925
185regulation of odontogenesis of dentin-containing tooth (GO:0042487)12.5788179
186regulation of odontogenesis (GO:0042481)12.4372081
187* odontogenesis (GO:0042476)11.0188293
188regulation of female receptivity (GO:0045924)10.6667341
189* biomineral tissue development (GO:0031214)10.4772095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.98880693
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.21595901
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.20473179
4HTT_18923047_ChIP-ChIP_STHdh_Human3.61868911
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.16573446
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12648843
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00215712
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72659545
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55218877
10KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.09924290
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.03552761
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87091135
13CLOCK_20551151_ChIP-Seq_293T_Human1.84296367
14EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83815059
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83815059
16PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82558957
17ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.79879581
18UBF1/2_26484160_Chip-Seq_HMECs_Human1.74889160
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74574213
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70544941
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.68958971
22SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67564670
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67102186
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65037442
25SMAD3_21741376_ChIP-Seq_HESCs_Human1.61799643
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61368262
27FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.60991212
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59628426
29FUS_26573619_Chip-Seq_HEK293_Human1.55553200
30ZNF263_19887448_ChIP-Seq_K562_Human1.54572883
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.53261102
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53213526
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52930047
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52198468
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51828224
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50217357
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48513393
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48267276
39TP53_20018659_ChIP-ChIP_R1E_Mouse1.47104395
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.44131980
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43502002
42SMAD4_21741376_ChIP-Seq_HESCs_Human1.43213033
43CJUN_26792858_Chip-Seq_BT549_Human1.42466497
44AR_21572438_ChIP-Seq_LNCaP_Human1.41274576
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40361102
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.39330633
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38908745
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36578217
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36460474
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35343019
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33696771
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32427802
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32427802
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.32140597
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31648612
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30840081
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30513893
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30473632
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28541090
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28509362
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27820842
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.26353416
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.25098380
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.24794710
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24104845
66ATF3_27146783_Chip-Seq_COLON_Human1.22769706
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21747982
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21303597
69VDR_24787735_ChIP-Seq_THP-1_Human1.18297106
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18292352
71BRD4_25478319_ChIP-Seq_HGPS_Human1.18269992
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17562856
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17547240
74LXR_22158963_ChIP-Seq_LIVER_Mouse1.16679694
75TP53_18474530_ChIP-ChIP_U2OS_Human1.15126735
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14952025
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14952025
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14952025
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.13362979
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12311032
81RXR_22108803_ChIP-Seq_LS180_Human1.11334799
82* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10402165
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.09868631
84CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09311496
85ELF5_23300383_ChIP-Seq_T47D_Human1.09297172
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.08925699
87CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07399178
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.06619305
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06425597
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05436653
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05329864
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05053801
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03084696
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.03065863
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.02114476
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01832310
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00565424
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.99309967
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.99063410
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98980318
101ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98969653
102ERG_21242973_ChIP-ChIP_JURKAT_Human0.97585109
103KDM2B_26808549_Chip-Seq_K562_Human0.97515871
104SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96858689
105RING1B_27294783_Chip-Seq_ESCs_Mouse0.96106368
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94623937
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93821203
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93417962
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93394743
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93394743
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92573619
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.92176278
113KDM2B_26808549_Chip-Seq_DND41_Human0.92075717
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91388048
115SOX2_20726797_ChIP-Seq_SW620_Human0.91004970
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90538125
117TCF4_18268006_ChIP-ChIP_LS174T_Human0.90457721
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90447307
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90288523
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90039227
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89788159
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88442573
123DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88400871
124EP300_21415370_ChIP-Seq_HL-1_Mouse0.88004869
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.86897554
126EWS_26573619_Chip-Seq_HEK293_Human0.86465656
127NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85279576
128* TP63_23658742_ChIP-Seq_EP156T_Human0.84734652
129TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84535269
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83046350
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.82575696
132TP53_16413492_ChIP-PET_HCT116_Human0.82367727
133AR_21909140_ChIP-Seq_LNCAP_Human0.81545992
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81530944
135AHR_22903824_ChIP-Seq_MCF-7_Human0.80716354
136BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80601978
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80465944
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80388614
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79801836
140SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79628856
141KDM2B_26808549_Chip-Seq_JURKAT_Human0.79579328
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.79006590
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.78223552
144PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77998677
145KLF5_25053715_ChIP-Seq_YYC3_Human0.77824049
146HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77271425
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.76696420
148PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76276650
149MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.75795559
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75781297
151KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.75106222
152NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.74269521
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.73819270
154TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73447725
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73205153
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.73114490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.38616443
2MP0003935_abnormal_craniofacial_develop4.90698078
3MP0005275_abnormal_skin_tensile4.82800822
4MP0000432_abnormal_head_morphology4.77120024
5MP0001849_ear_inflammation4.72000211
6MP0002653_abnormal_ependyma_morphology4.31294278
7MP0004272_abnormal_basement_membrane3.56405192
8MP0000537_abnormal_urethra_morphology3.32852422
9MP0005187_abnormal_penis_morphology3.08440158
10MP0003315_abnormal_perineum_morphology3.00764610
11MP0008438_abnormal_cutaneous_collagen2.96994770
12MP0000762_abnormal_tongue_morphology2.68890815
13MP0000613_abnormal_salivary_gland2.68764517
14MP0002060_abnormal_skin_morphology2.67063612
15MP0001542_abnormal_bone_strength2.62815370
16MP0000462_abnormal_digestive_system2.62600660
17MP0002877_abnormal_melanocyte_morpholog2.57328923
18MP0002254_reproductive_system_inflammat2.20899095
19MP0000372_irregular_coat_pigmentation2.20241280
20MP0000566_synostosis2.14234515
21MP0000750_abnormal_muscle_regeneration2.03522894
22MP0003300_gastrointestinal_ulcer1.99846693
23MP0000538_abnormal_urinary_bladder1.97462330
24MP0002896_abnormal_bone_mineralization1.93186589
25MP0003941_abnormal_skin_development1.90081855
26MP0009250_abnormal_appendicular_skeleto1.86967337
27MP0001299_abnormal_eye_distance/1.82364350
28MP0002116_abnormal_craniofacial_bone1.81265326
29MP0003943_abnormal_hepatobiliary_system1.70313928
30MP0000534_abnormal_ureter_morphology1.69142247
31MP0010030_abnormal_orbit_morphology1.68764954
32MP0005409_darkened_coat_color1.64276080
33MP0005646_abnormal_pituitary_gland1.61866620
34MP0004036_abnormal_muscle_relaxation1.60124849
35MP0003011_delayed_dark_adaptation1.57968764
36MP0003705_abnormal_hypodermis_morpholog1.56231591
37MP0001879_abnormal_lymphatic_vessel1.55899742
38MP0002909_abnormal_adrenal_gland1.54986608
39MP0005197_abnormal_uvea_morphology1.49411238
40MP0003566_abnormal_cell_adhesion1.46516371
41MP0002098_abnormal_vibrissa_morphology1.45842127
42MP0000163_abnormal_cartilage_morphology1.40540036
43MP0000733_abnormal_muscle_development1.38770933
44MP0000467_abnormal_esophagus_morphology1.34118106
45MP0000383_abnormal_hair_follicle1.32054774
46MP0001216_abnormal_epidermal_layer1.29872744
47MP0009379_abnormal_foot_pigmentation1.27941734
48MP0006054_spinal_hemorrhage1.27593021
49MP0002009_preneoplasia1.26609829
50MP0010234_abnormal_vibrissa_follicle1.25572046
51MP0010771_integument_phenotype1.25082333
52MP0003385_abnormal_body_wall1.24641206
53MP0005023_abnormal_wound_healing1.23445348
54MP0010678_abnormal_skin_adnexa1.23080999
55MP0010352_gastrointestinal_tract_polyps1.22547625
56MP0000604_amyloidosis1.21797256
57MP0000049_abnormal_middle_ear1.20553499
58MP0008260_abnormal_autophagy1.17994670
59MP0004808_abnormal_hematopoietic_stem1.15425986
60MP0009931_abnormal_skin_appearance1.15209868
61MP0003283_abnormal_digestive_organ1.14306178
62MP0002796_impaired_skin_barrier1.11795505
63MP0000627_abnormal_mammary_gland1.10875006
64MP0000647_abnormal_sebaceous_gland1.10495473
65MP0004885_abnormal_endolymph1.10175659
66MP0005193_abnormal_anterior_eye1.09577541
67MP0002998_abnormal_bone_remodeling1.08745063
68MP0000428_abnormal_craniofacial_morphol1.07766735
69MP0005501_abnormal_skin_physiology1.07358686
70MP0005408_hypopigmentation1.06644529
71MP0003755_abnormal_palate_morphology1.05526007
72MP0001270_distended_abdomen1.05125740
73MP0002249_abnormal_larynx_morphology1.05056542
74MP0009384_cardiac_valve_regurgitation1.03884841
75MP0005623_abnormal_meninges_morphology1.02722295
76MP0004134_abnormal_chest_morphology1.02522274
77MP0000858_altered_metastatic_potential1.02257861
78MP0002295_abnormal_pulmonary_circulatio1.02063711
79MP0003329_amyloid_beta_deposits1.00455233
80MP0006138_congestive_heart_failure0.95453501
81MP0008775_abnormal_heart_ventricle0.95279716
82MP0002115_abnormal_skeleton_extremities0.95084726
83MP0005503_abnormal_tendon_morphology0.95030400
84MP0008872_abnormal_physiological_respon0.94916738
85MP0004859_abnormal_synaptic_plasticity0.93461814
86MP0008932_abnormal_embryonic_tissue0.93405391
87MP0004782_abnormal_surfactant_physiolog0.93104673
88MP0009053_abnormal_anal_canal0.92697208
89MP0004185_abnormal_adipocyte_glucose0.92559954
90MP0005508_abnormal_skeleton_morphology0.91847492
91MP0003279_aneurysm0.91116189
92MP0001915_intracranial_hemorrhage0.90671242
93MP0001286_abnormal_eye_development0.89665722
94MP0010368_abnormal_lymphatic_system0.88761125
95MP0000579_abnormal_nail_morphology0.88719707
96MP0003693_abnormal_embryo_hatching0.87046291
97MP0002177_abnormal_outer_ear0.84966535
98MP0002109_abnormal_limb_morphology0.82135310
99MP0002282_abnormal_trachea_morphology0.81903493
100MP0001851_eye_inflammation0.81184779
101MP0003890_abnormal_embryonic-extraembry0.80982556
102MP0002233_abnormal_nose_morphology0.80856472
103MP0005248_abnormal_Harderian_gland0.80620095
104MP0003795_abnormal_bone_structure0.79082424
105MP0000367_abnormal_coat/_hair0.76137799
106MP0003787_abnormal_imprinting0.74317118
107MP0002751_abnormal_autonomic_nervous0.73781369
108MP0001186_pigmentation_phenotype0.73468922
109MP0002113_abnormal_skeleton_development0.71788573
110MP0001324_abnormal_eye_pigmentation0.70671129
111MP0009780_abnormal_chondrocyte_physiolo0.70005031
112MP0002108_abnormal_muscle_morphology0.69924238
113MP0005381_digestive/alimentary_phenotyp0.69633334
114MP0002092_abnormal_eye_morphology0.68518162
115MP0000377_abnormal_hair_follicle0.68345912
116MP0004858_abnormal_nervous_system0.67865180
117MP0005171_absent_coat_pigmentation0.67197255
118MP0001348_abnormal_lacrimal_gland0.65929742
119MP0002075_abnormal_coat/hair_pigmentati0.65419968
120MP0003634_abnormal_glial_cell0.65383857
121MP0003937_abnormal_limbs/digits/tail_de0.65306557
122MP0001346_abnormal_lacrimal_gland0.64844304
123MP0005166_decreased_susceptibility_to0.64174133
124MP0004381_abnormal_hair_follicle0.62967358
125MP0003136_yellow_coat_color0.62558308
126MP0003448_altered_tumor_morphology0.62456748
127MP0001340_abnormal_eyelid_morphology0.62193768
128MP0003880_abnormal_central_pattern0.61950755
129MP0010630_abnormal_cardiac_muscle0.61643731
130MP0003942_abnormal_urinary_system0.60969896
131MP0000470_abnormal_stomach_morphology0.60878075
132MP0002638_abnormal_pupillary_reflex0.59097068
133MP0003453_abnormal_keratinocyte_physiol0.58907699
134MP0004270_analgesia0.56432201
135MP0001243_abnormal_dermal_layer0.53808746
136MP0004084_abnormal_cardiac_muscle0.49349683
137MP0004484_altered_response_of0.48818977
138MP0005257_abnormal_intraocular_pressure0.48771301
139MP0005360_urolithiasis0.47604858
140MP0001664_abnormal_digestion0.46595597
141MP0000343_altered_response_to0.46549514
142MP0003938_abnormal_ear_development0.44403700
143MP0002932_abnormal_joint_morphology0.43999249
144MP0005390_skeleton_phenotype0.43399637
145MP0002697_abnormal_eye_size0.42240505

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)8.54113886
2Milia (HP:0001056)7.80407730
3Fragile nails (HP:0001808)7.71664923
4Stomach cancer (HP:0012126)5.55974123
5Microglossia (HP:0000171)5.35767070
6Ependymoma (HP:0002888)5.06693828
7Abnormality of dental color (HP:0011073)5.03715810
8Abnormality of the astrocytes (HP:0100707)4.60461937
9Astrocytoma (HP:0009592)4.60461937
10Amelogenesis imperfecta (HP:0000705)30.4500486
11Plantar hyperkeratosis (HP:0007556)3.93699415
12Hypoplasia of dental enamel (HP:0006297)3.61723221
13Choroideremia (HP:0001139)3.38087364
14Glioma (HP:0009733)3.34376131
15Pterygium (HP:0001059)3.27959002
16Abnormality of nail color (HP:0100643)3.13647701
17Vertebral compression fractures (HP:0002953)3.11687181
18Metaphyseal cupping (HP:0003021)3.05495049
19Thick nail (HP:0001805)3.03918436
20Buphthalmos (HP:0000557)2.84522916
21Alveolar cell carcinoma (HP:0006519)2.81825275
22Abnormal finger flexion creases (HP:0006143)2.79239627
23Nail dystrophy (HP:0008404)2.71689684
24Neurofibrillary tangles (HP:0002185)2.69410412
25Back pain (HP:0003418)2.67708755
26Absent phalangeal crease (HP:0006109)2.66498601
27Nasolacrimal duct obstruction (HP:0000579)2.65661817
28Subacute progressive viral hepatitis (HP:0006572)2.64486952
29Vascular tortuosity (HP:0004948)2.58901884
30Widely patent fontanelles and sutures (HP:0004492)2.49009907
31Short nail (HP:0001799)2.47908693
32Focal segmental glomerulosclerosis (HP:0000097)2.47467100
33Neoplasm of the tracheobronchial system (HP:0100552)2.45323815
34Cerebral inclusion bodies (HP:0100314)2.42931905
35Abnormality of the dental root (HP:0006486)2.40824877
36Taurodontia (HP:0000679)2.40824877
37Abnormality of permanent molar morphology (HP:0011071)2.40824877
38Sparse eyelashes (HP:0000653)2.38562458
39Corneal erosion (HP:0200020)2.35717703
40Abnormality of the fovea (HP:0000493)2.28839917
41Abnormality of molar morphology (HP:0011070)2.26589832
42Abnormality of molar (HP:0011077)2.26589832
43Interstitial pulmonary disease (HP:0006530)2.25861390
44Broad metatarsal (HP:0001783)2.21414094
45Severe visual impairment (HP:0001141)2.20664236
46Hypodontia (HP:0000668)2.19287267
47Ankyloglossia (HP:0010296)2.18122606
48Abnormality of oral frenula (HP:0000190)2.17883051
49Death in infancy (HP:0001522)2.16816924
50Abnormality of the nasolacrimal system (HP:0000614)2.11232616
51Partial duplication of the phalanx of hand (HP:0009999)2.09049458
52Vertebral hypoplasia (HP:0008417)2.08763493
53Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.08763493
54Hallux valgus (HP:0001822)2.07104265
55Esophageal atresia (HP:0002032)2.06108826
56Abnormality of the dental pulp (HP:0006479)2.05661632
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.03479681
58Congenital glaucoma (HP:0001087)2.02524276
59Abnormality of the lacrimal duct (HP:0011481)2.02062899
60Hyporeflexia of lower limbs (HP:0002600)2.00814413
61Onycholysis (HP:0001806)12.3425576
62Recurrent corneal erosions (HP:0000495)1.93717003
63Short middle phalanx of the 5th finger (HP:0004220)1.93191489
64Premature loss of primary teeth (HP:0006323)1.93149398
65Glomerulosclerosis (HP:0000096)1.92737170
66Palmoplantar hyperkeratosis (HP:0000972)1.92609489
67Protrusio acetabuli (HP:0003179)1.91826732
68Osteomalacia (HP:0002749)1.91805802
69Cervical subluxation (HP:0003308)1.86295813
70Unilateral renal agenesis (HP:0000122)1.86057638
71Rimmed vacuoles (HP:0003805)1.85748869
72Abnormality of the thoracic spine (HP:0100711)1.84967764
73Split foot (HP:0001839)1.83501841
74Aplasia involving bones of the upper limbs (HP:0009823)1.80018299
75Aplasia of the phalanges of the hand (HP:0009802)1.80018299
76Aplasia involving bones of the extremities (HP:0009825)1.80018299
77Autoamputation (HP:0001218)1.79153831
78Mitral stenosis (HP:0001718)1.78794303
79Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78364383
80Delayed cranial suture closure (HP:0000270)1.77500108
81Parakeratosis (HP:0001036)1.77309101
82Amniotic constriction ring (HP:0009775)1.77306276
83Abnormality of placental membranes (HP:0011409)1.77306276
84Conical tooth (HP:0000698)1.77265486
85Palmar hyperkeratosis (HP:0010765)1.77155733
86Natal tooth (HP:0000695)1.75943108
87Pili torti (HP:0003777)1.75929739
88Wide cranial sutures (HP:0010537)1.75788079
89Shallow orbits (HP:0000586)1.74979303
90Weak cry (HP:0001612)1.73949932
91Abnormality of the phalanges of the 5th finger (HP:0004213)1.73524112
92Rhizomelia (HP:0008905)1.73011607
93Premature rupture of membranes (HP:0001788)1.69257247
94Turricephaly (HP:0000262)1.63938219
95Ulnar bowing (HP:0003031)1.62916386
96Abnormal blistering of the skin (HP:0008066)1.61288422
97Pyloric stenosis (HP:0002021)1.58681642
98Abnormality of the frontal sinuses (HP:0002687)1.55902321
99Anosmia (HP:0000458)1.55864621
100Spondylolisthesis (HP:0003302)1.55038335
101Dehydration (HP:0001944)1.54156669
102Carious teeth (HP:0000670)1.54062986
103Abnormality of the costochondral junction (HP:0000919)1.53705538
104Microdontia (HP:0000691)1.53527054
105Abnormality of the parietal bone (HP:0002696)1.52554661
106Absent frontal sinuses (HP:0002688)1.50094892
107Hoarse voice (HP:0001609)1.49597333
108Fragile skin (HP:0001030)1.47798192
109Right ventricular cardiomyopathy (HP:0011663)1.45562466
110Dental malocclusion (HP:0000689)1.45242466
111Bronchomalacia (HP:0002780)1.40242068
112Coronal craniosynostosis (HP:0004440)1.40208242
113Blue sclerae (HP:0000592)1.39230077
114Aplasia cutis congenita (HP:0001057)1.38281358
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.35292244
116Vertebral clefting (HP:0008428)1.32740863
117Aortic dissection (HP:0002647)1.32523682
118Oligodontia (HP:0000677)1.30747711
119Wormian bones (HP:0002645)1.30702544
120Multiple enchondromatosis (HP:0005701)1.30665743
121Osteolytic defects of the hand bones (HP:0009699)1.29869157
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.29869157
123Decreased skull ossification (HP:0004331)1.29275931
124Oligodactyly (hands) (HP:0001180)1.28229658
125Enlarged penis (HP:0000040)1.27265265
126Hypotrichosis (HP:0001006)1.23889399
127X-linked dominant inheritance (HP:0001423)1.19240069
128Cerebral aneurysm (HP:0004944)1.18759864
129Heterogeneous (HP:0001425)1.16468072
130Irregular vertebral endplates (HP:0003301)1.16340749
131Abnormality of primary teeth (HP:0006481)1.16193296
132Autoimmune thrombocytopenia (HP:0001973)1.15724104
133Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.13525287
134Short hallux (HP:0010109)1.10348736
135Abnormality of skull ossification (HP:0002703)1.09437410
136Abnormal vertebral ossification (HP:0100569)1.07968725
137Abnormality of dentin (HP:0010299)1.07291061
138Small epiphyses (HP:0010585)1.06598883
139Mitral valve prolapse (HP:0001634)1.05991186
140Epileptic encephalopathy (HP:0200134)1.05821258
141Synostosis involving the elbow (HP:0003938)1.05584834
142Humeroradial synostosis (HP:0003041)1.05584834
143Alopecia of scalp (HP:0002293)1.05580718
144Absent eyebrow (HP:0002223)1.04407025
145Bowing of the arm (HP:0006488)1.01416594
146Bowed forearm bones (HP:0003956)1.01416594
147Hyperhidrosis (HP:0000975)1.00292712
148Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)0.99914488
149Choanal stenosis (HP:0000452)0.99324499
150Ridged nail (HP:0001807)0.99318290
151Aplasia/Hypoplasia of the hallux (HP:0008362)0.99145911
152Short middle phalanx of finger (HP:0005819)0.98255264
153Arterial tortuosity (HP:0005116)0.97190099
154Narrow nasal bridge (HP:0000446)0.95737982
155Striae distensae (HP:0001065)0.95736597
156Syringomyelia (HP:0003396)0.93450631
157Spinal cord lesions (HP:0100561)0.93450631
158Short 5th finger (HP:0009237)0.93223690
159Camptodactyly of finger (HP:0100490)0.91426040
160Rickets (HP:0002748)0.90424676
161Aplasia/Hypoplasia of the 5th finger (HP:0006262)0.90271589
162Bladder diverticulum (HP:0000015)0.90092733
163Selective tooth agenesis (HP:0001592)0.89726959
164Deviation of the hallux (HP:0010051)0.89610368
165Abnormality of the middle phalanx of the 5th finger (HP:0004219)0.89296511
166Abnormality of the fingernails (HP:0001231)0.88582659
167Status epilepticus (HP:0002133)0.87715104
168Radial bowing (HP:0002986)0.87553360

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K36.16691442
2MATK5.03483000
3MST1R4.66328517
4TRPM74.63947947
5CDK63.78839850
6MAP3K123.22263424
7STK243.17979363
8BMX2.61628965
9FGFR22.43824686
10CAMK42.33189890
11TRIB32.25548495
12TGFBR12.16387871
13STK38L2.13630466
14CSNK1A12.13394167
15RIPK12.10607323
16PDGFRA1.99025771
17DYRK1A1.83846471
18CAMK11.83547614
19LRRK21.77582966
20TGFBR21.57537013
21FGFR11.55712177
22LMTK21.55253299
23PAK41.49433097
24DDR21.47235783
25EPHB11.46454420
26PIM21.44753176
27PHKG11.44395883
28PHKG21.44395883
29EPHA21.41233842
30CDK91.36996924
31NTRK11.35624222
32FER1.33531632
33TESK11.30123608
34PKN21.27316854
35TLK11.26309105
36PRKD11.18569679
37DYRK1B1.16923074
38RET1.15065604
39HIPK21.14237193
40MAPK41.13735065
41STK31.13698663
42CDK81.13664549
43TTN1.13367635
44NEK91.12709665
45PNCK1.11519063
46MAP3K61.11236191
47PAK21.11233580
48PASK1.09789418
49PAK31.09618631
50SCYL21.09409067
51MYLK1.09271237
52BRSK11.08033979
53PTK61.06849649
54PTK21.05553454
55PAK61.02869460
56EPHA41.02821562
57NTRK31.01296193
58GSK3A1.01260386
59ILK1.00938747
60LATS11.00885388
61PBK1.00189226
62ARAF0.97825883
63PRKD30.97659896
64EPHA30.97619437
65STK380.97250015
66CAMK1G0.95367460
67MAP3K70.93161815
68LIMK10.89696489
69PRKCE0.89561804
70KSR20.87603948
71PDK20.86594826
72MAPK120.83778720
73FGFR40.82990124
74MOS0.81863342
75ERN10.81761353
76CSNK1A1L0.81602307
77MAP3K20.76780742
78MUSK0.76728200
79FGR0.76151688
80SIK10.73510013
81MELK0.73268519
82DAPK20.72035029
83CDK40.71580677
84PRKCZ0.70229949
85TYRO30.69451831
86MAP3K90.69328018
87MINK10.69010795
88BCR0.68885283
89UHMK10.68706108
90LATS20.68700605
91ERBB40.67011192
92CDC42BPA0.66932387
93PDGFRB0.65611950
94CAMKK10.63281211
95CDK140.62190015
96BMPR1B0.60579543
97CDK50.60508195
98ROCK20.60297308
99PRKCH0.59575336
100PIK3CA0.59284247
101TRIM280.59229641
102CDK190.59033561
103DAPK30.58649524
104CAMK2A0.57921269
105MAPK70.57875615
106ERBB30.57651457
107EIF2AK10.56377602
108FLT30.55786569
109KSR10.55461868
110CDK150.54666536
111EPHB20.54137481
112DYRK30.52741069
113NEK10.51753394
114CDK180.51499652
115SRPK10.51378171
116RIPK40.50713162
117FGFR30.49673881
118SRC0.48701433
119CSNK1G30.47823100
120MAPKAPK20.47588373
121NME20.47358476
122CSNK1G20.47330368
123FYN0.46845527
124PTK2B0.46578336
125CDK11A0.46518673
126MAP2K10.45975718
127ROCK10.45554415
128INSRR0.45193996
129CSNK1G10.44961287
130DMPK0.44357571
131MET0.43843345
132IGF1R0.42091780
133EGFR0.40258646
134MAP3K100.39737685
135PLK20.39032620
136BUB10.37690716
137CDK120.37413907
138ALK0.36583613
139BMPR20.36558963
140NEK60.36403913
141ERBB20.34507503
142STK100.33899378
143CSK0.33746990
144CAMK2B0.32699999
145ABL10.31783919
146FES0.31679832
147PINK10.30597496
148RPS6KA20.29788301
149CLK10.29477952
150NLK0.26046623
151STK160.22538112
152PRKD20.20121807
153RPS6KB10.18687740
154RAF10.18369363
155TTK0.18081379

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.64675856
2Amoebiasis_Homo sapiens_hsa051463.13839685
3Vitamin B6 metabolism_Homo sapiens_hsa007503.03463980
4Folate biosynthesis_Homo sapiens_hsa007902.88364096
5Small cell lung cancer_Homo sapiens_hsa052222.86343031
6Focal adhesion_Homo sapiens_hsa045102.45280588
7Toxoplasmosis_Homo sapiens_hsa051452.22291593
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.19785521
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.00551162
10Basal cell carcinoma_Homo sapiens_hsa052171.90984241
11Protein export_Homo sapiens_hsa030601.87873520
12Cocaine addiction_Homo sapiens_hsa050301.86981512
13Proteasome_Homo sapiens_hsa030501.85126250
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84138020
15Nitrogen metabolism_Homo sapiens_hsa009101.82829674
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.81163187
17Hedgehog signaling pathway_Homo sapiens_hsa043401.70520488
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68190779
19Proteoglycans in cancer_Homo sapiens_hsa052051.57573555
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54942841
21Gastric acid secretion_Homo sapiens_hsa049711.40291309
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38829659
23PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38253699
24GnRH signaling pathway_Homo sapiens_hsa049121.33929966
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32382124
26ErbB signaling pathway_Homo sapiens_hsa040121.31654062
27N-Glycan biosynthesis_Homo sapiens_hsa005101.31392289
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30638230
29Hippo signaling pathway_Homo sapiens_hsa043901.29167426
30Adherens junction_Homo sapiens_hsa045201.29054536
31Circadian rhythm_Homo sapiens_hsa047101.28095014
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27725943
33Wnt signaling pathway_Homo sapiens_hsa043101.26377569
34Bile secretion_Homo sapiens_hsa049761.25256365
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24544481
36Tyrosine metabolism_Homo sapiens_hsa003501.20789956
37Salivary secretion_Homo sapiens_hsa049701.17143860
38Melanogenesis_Homo sapiens_hsa049161.14231111
39HIF-1 signaling pathway_Homo sapiens_hsa040661.13661584
40Pathways in cancer_Homo sapiens_hsa052001.13071601
41Alcoholism_Homo sapiens_hsa050341.10943872
42Mineral absorption_Homo sapiens_hsa049781.10488971
43TGF-beta signaling pathway_Homo sapiens_hsa043501.06739099
44Bladder cancer_Homo sapiens_hsa052191.05840019
45Ribosome_Homo sapiens_hsa030101.05219416
46Dilated cardiomyopathy_Homo sapiens_hsa054141.03219540
47Vibrio cholerae infection_Homo sapiens_hsa051101.01193991
48MicroRNAs in cancer_Homo sapiens_hsa052061.01139431
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00498149
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.98112931
51Collecting duct acid secretion_Homo sapiens_hsa049660.96559766
52Long-term depression_Homo sapiens_hsa047300.95685528
53Sphingolipid metabolism_Homo sapiens_hsa006000.94606788
54Glioma_Homo sapiens_hsa052140.94597130
55Tight junction_Homo sapiens_hsa045300.93686514
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.93443406
57Protein digestion and absorption_Homo sapiens_hsa049740.90225015
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89837592
59Long-term potentiation_Homo sapiens_hsa047200.88233548
60Thyroid hormone synthesis_Homo sapiens_hsa049180.87995272
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87665420
62Synaptic vesicle cycle_Homo sapiens_hsa047210.87513943
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87154943
64Circadian entrainment_Homo sapiens_hsa047130.85916218
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85580583
66Phenylalanine metabolism_Homo sapiens_hsa003600.85480263
67Chronic myeloid leukemia_Homo sapiens_hsa052200.85402791
68Complement and coagulation cascades_Homo sapiens_hsa046100.83827302
69Gap junction_Homo sapiens_hsa045400.82494802
70Inositol phosphate metabolism_Homo sapiens_hsa005620.82469588
71Pancreatic secretion_Homo sapiens_hsa049720.81889967
72Arginine biosynthesis_Homo sapiens_hsa002200.78662421
73Axon guidance_Homo sapiens_hsa043600.78589129
74Platelet activation_Homo sapiens_hsa046110.78297530
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77838672
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77720736
77Notch signaling pathway_Homo sapiens_hsa043300.75325440
78Prion diseases_Homo sapiens_hsa050200.74588171
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74124393
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73678667
81Melanoma_Homo sapiens_hsa052180.73345775
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71596743
83GABAergic synapse_Homo sapiens_hsa047270.70825789
84Prostate cancer_Homo sapiens_hsa052150.68617711
85Cholinergic synapse_Homo sapiens_hsa047250.68547367
86Thyroid cancer_Homo sapiens_hsa052160.68503840
87Insulin secretion_Homo sapiens_hsa049110.68489371
88Renin secretion_Homo sapiens_hsa049240.68223266
89Estrogen signaling pathway_Homo sapiens_hsa049150.66854606
90Amphetamine addiction_Homo sapiens_hsa050310.65810726
91Glutamatergic synapse_Homo sapiens_hsa047240.65708759
92Rheumatoid arthritis_Homo sapiens_hsa053230.65211165
93Phagosome_Homo sapiens_hsa041450.64872800
94Olfactory transduction_Homo sapiens_hsa047400.64598782
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64495123
96Oxytocin signaling pathway_Homo sapiens_hsa049210.63199198
97Alzheimers disease_Homo sapiens_hsa050100.62634975
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62547541
99Choline metabolism in cancer_Homo sapiens_hsa052310.61857200
100Dopaminergic synapse_Homo sapiens_hsa047280.59941878
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58369009
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58129626
103Endometrial cancer_Homo sapiens_hsa052130.55176986
104Rap1 signaling pathway_Homo sapiens_hsa040150.54289179
105Pancreatic cancer_Homo sapiens_hsa052120.54139752
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54122780
107Pentose phosphate pathway_Homo sapiens_hsa000300.53930660
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53220778
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53095079
110Dorso-ventral axis formation_Homo sapiens_hsa043200.52912133
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52720704
112Basal transcription factors_Homo sapiens_hsa030220.51593471
113Sulfur metabolism_Homo sapiens_hsa009200.50969997
114Histidine metabolism_Homo sapiens_hsa003400.50513444
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.50322563
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49589904
117Butanoate metabolism_Homo sapiens_hsa006500.48829932
118beta-Alanine metabolism_Homo sapiens_hsa004100.48729321
119Non-small cell lung cancer_Homo sapiens_hsa052230.48620250
120Endocytosis_Homo sapiens_hsa041440.47324189
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46714840
122Viral carcinogenesis_Homo sapiens_hsa052030.46315288
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45865660
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45593128
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.45418481
126Renal cell carcinoma_Homo sapiens_hsa052110.44734507
127Insulin signaling pathway_Homo sapiens_hsa049100.44029442
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43222345
129Cell cycle_Homo sapiens_hsa041100.42397117
130Lysosome_Homo sapiens_hsa041420.42341613
131mTOR signaling pathway_Homo sapiens_hsa041500.41825114
132Cardiac muscle contraction_Homo sapiens_hsa042600.41745087
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39049160
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38241011
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.37915352
136Glucagon signaling pathway_Homo sapiens_hsa049220.37849477
137Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36199140
138Ovarian steroidogenesis_Homo sapiens_hsa049130.35021750
139Starch and sucrose metabolism_Homo sapiens_hsa005000.34812675
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34318190
141Steroid biosynthesis_Homo sapiens_hsa001000.33934357
142Malaria_Homo sapiens_hsa051440.33324871
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33211079
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.32939402
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32916775
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32659305
147HTLV-I infection_Homo sapiens_hsa051660.32018555
148Nucleotide excision repair_Homo sapiens_hsa034200.31891813
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31572304
150Shigellosis_Homo sapiens_hsa051310.30743287
151Huntingtons disease_Homo sapiens_hsa050160.30565782
152Pyruvate metabolism_Homo sapiens_hsa006200.30330913
153Oxidative phosphorylation_Homo sapiens_hsa001900.28918835

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