AMER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.98834923
2locomotory exploration behavior (GO:0035641)5.69571425
3synaptic vesicle maturation (GO:0016188)5.59323595
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.55495771
5vocalization behavior (GO:0071625)5.54411828
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48041129
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.38163619
8regulation of synaptic vesicle exocytosis (GO:2000300)5.27240104
9synaptic vesicle exocytosis (GO:0016079)5.23405692
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.12620199
11regulation of glutamate receptor signaling pathway (GO:1900449)5.07788519
12protein localization to synapse (GO:0035418)4.91399507
13neuron cell-cell adhesion (GO:0007158)4.88929004
14glutamate secretion (GO:0014047)4.76938619
15exploration behavior (GO:0035640)4.74037868
16layer formation in cerebral cortex (GO:0021819)4.61172520
17regulation of synaptic vesicle transport (GO:1902803)4.56876908
18synaptic transmission, glutamatergic (GO:0035249)4.54926495
19glutamate receptor signaling pathway (GO:0007215)4.53614770
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.53133037
21regulation of synapse structural plasticity (GO:0051823)4.39076842
22dendritic spine morphogenesis (GO:0060997)4.38957119
23neuronal action potential propagation (GO:0019227)4.38129101
24regulation of neuronal synaptic plasticity (GO:0048168)4.34443582
25neurotransmitter secretion (GO:0007269)4.28991111
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.28561863
27neuron recognition (GO:0008038)4.19696570
28neurotransmitter-gated ion channel clustering (GO:0072578)4.18815570
29positive regulation of synapse maturation (GO:0090129)4.16624425
30gamma-aminobutyric acid transport (GO:0015812)4.12687480
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.11992910
32neuron-neuron synaptic transmission (GO:0007270)4.11248589
33behavioral response to nicotine (GO:0035095)4.10985978
34long-term memory (GO:0007616)3.97847257
35axonal fasciculation (GO:0007413)3.97515450
36proline transport (GO:0015824)3.94267456
37pyrimidine nucleobase catabolic process (GO:0006208)3.91209601
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84955299
39dendrite morphogenesis (GO:0048813)3.81118383
40postsynaptic membrane organization (GO:0001941)3.78974160
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.77794889
42positive regulation of membrane potential (GO:0045838)3.71418856
43startle response (GO:0001964)3.69700937
44activation of protein kinase A activity (GO:0034199)3.68821336
45regulation of postsynaptic membrane potential (GO:0060078)3.66207269
46regulation of dendritic spine morphogenesis (GO:0061001)3.65166103
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59131353
48negative regulation of microtubule polymerization (GO:0031115)3.57239117
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55162378
50cell migration in hindbrain (GO:0021535)3.53400571
51regulation of neurotransmitter secretion (GO:0046928)3.51425732
52synaptic vesicle endocytosis (GO:0048488)3.51133688
53cerebellar Purkinje cell differentiation (GO:0021702)3.50038214
54neurotransmitter transport (GO:0006836)3.49501838
55cerebellar granule cell differentiation (GO:0021707)3.48816470
56central nervous system projection neuron axonogenesis (GO:0021952)3.47160488
57gamma-aminobutyric acid signaling pathway (GO:0007214)3.43623418
58regulation of synaptic plasticity (GO:0048167)3.43399308
59neuromuscular process controlling balance (GO:0050885)3.42377988
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.42263735
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39972472
62transmission of nerve impulse (GO:0019226)3.39731155
63positive regulation of neurotransmitter secretion (GO:0001956)3.39062735
64innervation (GO:0060384)3.38608225
65insulin secretion (GO:0030073)3.37344449
66cellular potassium ion homeostasis (GO:0030007)3.37043567
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.33629481
68positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32030627
69positive regulation of dendritic spine morphogenesis (GO:0061003)3.30394211
70auditory behavior (GO:0031223)3.29163399
71regulation of vesicle fusion (GO:0031338)3.28836537
72nucleobase catabolic process (GO:0046113)3.27744903
73positive regulation of dendritic spine development (GO:0060999)3.24523656
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.24235698
75synapse assembly (GO:0007416)3.23228694
76cell communication by electrical coupling (GO:0010644)3.23088683
77presynaptic membrane assembly (GO:0097105)3.21208645
78behavioral defense response (GO:0002209)3.20828319
79behavioral fear response (GO:0001662)3.20828319
80water-soluble vitamin biosynthetic process (GO:0042364)3.20357863
81regulation of neurotransmitter levels (GO:0001505)3.18896962
82membrane depolarization (GO:0051899)3.17865016
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17575395
84cellular ketone body metabolic process (GO:0046950)3.17530652
85regulation of neurotransmitter transport (GO:0051588)3.15921282
86protein localization to cilium (GO:0061512)3.15712577
87long-term synaptic potentiation (GO:0060291)3.15091171
88regulation of synapse maturation (GO:0090128)3.15006252
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14982471
90presynaptic membrane organization (GO:0097090)3.13177567
91response to pheromone (GO:0019236)3.12999809
92positive regulation of neurotransmitter transport (GO:0051590)3.12846048
93negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12754122
94regulation of neurotransmitter uptake (GO:0051580)3.11966618
95regulation of dendritic spine development (GO:0060998)3.11452285
96prepulse inhibition (GO:0060134)3.10970061
97membrane depolarization during action potential (GO:0086010)3.10520112
98regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10341002
99positive regulation of synapse assembly (GO:0051965)3.09669656
100sodium ion export (GO:0071436)3.09232044
101organelle transport along microtubule (GO:0072384)3.04197901
102glycerophospholipid catabolic process (GO:0046475)3.04082461
103response to auditory stimulus (GO:0010996)3.03757387
104intraspecies interaction between organisms (GO:0051703)3.03061095
105social behavior (GO:0035176)3.03061095
106regulation of calcium ion-dependent exocytosis (GO:0017158)3.02769187
107membrane hyperpolarization (GO:0060081)3.02381868
108regulation of glucokinase activity (GO:0033131)3.02264137
109regulation of hexokinase activity (GO:1903299)3.02264137
110learning (GO:0007612)3.02045008
111fear response (GO:0042596)3.00073438
112dendritic spine organization (GO:0097061)2.99383731
113positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.97523679
114neuromuscular process controlling posture (GO:0050884)2.94899287
115reflex (GO:0060004)2.92741631
116calcium ion-dependent exocytosis (GO:0017156)2.92274592
117inositol phosphate catabolic process (GO:0071545)2.92125993
118glycosphingolipid biosynthetic process (GO:0006688)2.90558825
119regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90496485
120regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90496485
121neuronal action potential (GO:0019228)2.88387078
122serotonin metabolic process (GO:0042428)2.85880219
123primary amino compound metabolic process (GO:1901160)2.85441267
124adaptation of signaling pathway (GO:0023058)2.82147398
125ketone body metabolic process (GO:1902224)2.80369595
126negative regulation of hormone biosynthetic process (GO:0032353)2.78934533
127calcium ion import (GO:0070509)2.75576123
128neuromuscular synaptic transmission (GO:0007274)2.71834122
129detection of calcium ion (GO:0005513)2.69123340
130righting reflex (GO:0060013)2.68313648
131positive regulation of meiosis (GO:0045836)2.62933555
132protein polyglutamylation (GO:0018095)2.60874847
133positive regulation of amine transport (GO:0051954)2.60869423
134action potential (GO:0001508)2.60521141
135chemosensory behavior (GO:0007635)2.57536026
136regulation of type B pancreatic cell apoptotic process (GO:2000674)2.56247358
137positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.55611088
138atrial cardiac muscle cell action potential (GO:0086014)2.54983209
139endocrine pancreas development (GO:0031018)2.54981983
140cochlea development (GO:0090102)2.53217293
141alanine transport (GO:0032328)2.52341823
142axoneme assembly (GO:0035082)2.51284377
143respiratory chain complex IV assembly (GO:0008535)2.51200892
144signal release (GO:0023061)2.49231604
145cellular response to ATP (GO:0071318)2.48688023
146adult walking behavior (GO:0007628)2.47497040
147positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.46422304
148negative regulation of dendrite development (GO:2000171)2.46088929
149response to dietary excess (GO:0002021)2.45906627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.82225876
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.83589303
3GBX2_23144817_ChIP-Seq_PC3_Human3.45827875
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14229033
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12628953
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04056178
7REST_21632747_ChIP-Seq_MESCs_Mouse2.82038077
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81579070
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81579070
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62597399
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61678270
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.59099661
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53493471
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.51597991
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51515407
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51152080
17DROSHA_22980978_ChIP-Seq_HELA_Human2.51059120
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50783364
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.36377586
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.34553976
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.34371245
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32153853
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30171053
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28556813
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18302014
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.17194522
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.02570025
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96049045
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89686038
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85291301
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81612790
32AR_21572438_ChIP-Seq_LNCaP_Human1.75424421
33FUS_26573619_Chip-Seq_HEK293_Human1.74268394
34VDR_22108803_ChIP-Seq_LS180_Human1.68074099
35IGF1R_20145208_ChIP-Seq_DFB_Human1.67700075
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.63013922
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61445442
38ZNF274_21170338_ChIP-Seq_K562_Hela1.60550116
39SMAD4_21799915_ChIP-Seq_A2780_Human1.58404814
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53341025
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51792916
42TAF15_26573619_Chip-Seq_HEK293_Human1.50505631
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.49743475
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45824131
45ER_23166858_ChIP-Seq_MCF-7_Human1.43376191
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41979227
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.41857841
48RING1B_27294783_Chip-Seq_ESCs_Mouse1.39339697
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37945812
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35352971
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33205027
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32906498
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32567987
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.30768826
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29676323
56P300_19829295_ChIP-Seq_ESCs_Human1.29183931
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27254916
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26517224
59CBP_20019798_ChIP-Seq_JUKART_Human1.26517224
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25414931
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24615484
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.24335690
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23602770
64AR_19668381_ChIP-Seq_PC3_Human1.22777155
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.22463011
66AR_25329375_ChIP-Seq_VCAP_Human1.22353308
67TP53_22573176_ChIP-Seq_HFKS_Human1.22067041
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21321173
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.17546188
70BCAT_22108803_ChIP-Seq_LS180_Human1.17227561
71RNF2_27304074_Chip-Seq_NSC_Mouse1.16895387
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16209942
73EWS_26573619_Chip-Seq_HEK293_Human1.15291560
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14597534
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13657294
76P53_22387025_ChIP-Seq_ESCs_Mouse1.13052389
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12664228
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12264250
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11671623
80STAT3_23295773_ChIP-Seq_U87_Human1.11639032
81KDM2B_26808549_Chip-Seq_K562_Human1.10155491
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10069256
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09415332
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.09204025
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09120884
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08901132
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07657501
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06630513
89HTT_18923047_ChIP-ChIP_STHdh_Human1.06597843
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06221301
91TCF4_22108803_ChIP-Seq_LS180_Human1.04898219
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04893815
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04873817
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.04099463
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04056281
96EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02990525
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02031137
98YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02009118
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.01937095
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01763212
101TCF4_23295773_ChIP-Seq_U87_Human1.00839121
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.00155939
103SMAD3_21741376_ChIP-Seq_ESCs_Human0.99722971
104NANOG_19829295_ChIP-Seq_ESCs_Human0.99629122
105SOX2_19829295_ChIP-Seq_ESCs_Human0.99629122
106CMYC_18555785_Chip-Seq_ESCs_Mouse0.99559921
107AHR_22903824_ChIP-Seq_MCF-7_Human0.99332671
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99001406
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.98839987
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.98322344
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.96706160
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96552584
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96552584
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96203609
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95689985
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95655187
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94889001
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94469891
119ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94186309
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.93829797
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93737932
122RUNX2_22187159_ChIP-Seq_PCA_Human0.92697990
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92251667
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91129612
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90873395
126JUN_21703547_ChIP-Seq_K562_Human0.88820404
127TET1_21490601_ChIP-Seq_MESCs_Mouse0.88602360
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87943155
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.86461445
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84770514
131UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83724449
132SMAD4_21741376_ChIP-Seq_EPCs_Human0.83493586
133CTCF_27219007_Chip-Seq_Bcells_Human0.81915429
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81173454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.72722312
2MP0003880_abnormal_central_pattern4.63685776
3MP0003635_abnormal_synaptic_transmissio4.28246915
4MP0004270_analgesia3.76587866
5MP0002063_abnormal_learning/memory/cond3.52687116
6MP0009745_abnormal_behavioral_response3.33173561
7MP0001968_abnormal_touch/_nociception3.33074544
8MP0002064_seizures3.07140830
9MP0005423_abnormal_somatic_nervous3.05419049
10MP0009046_muscle_twitch3.03020482
11MP0002572_abnormal_emotion/affect_behav2.90269483
12MP0002734_abnormal_mechanical_nocicepti2.82295626
13MP0002735_abnormal_chemical_nociception2.72491089
14MP0002272_abnormal_nervous_system2.51884093
15MP0002736_abnormal_nociception_after2.50698172
16MP0001486_abnormal_startle_reflex2.47048640
17MP0000778_abnormal_nervous_system2.32963259
18MP0001440_abnormal_grooming_behavior2.23965782
19MP0002733_abnormal_thermal_nociception2.23364744
20MP0002184_abnormal_innervation2.19659477
21MP0008877_abnormal_DNA_methylation2.13502561
22MP0002102_abnormal_ear_morphology2.10818191
23MP0002067_abnormal_sensory_capabilities2.07884512
24MP0001970_abnormal_pain_threshold2.07008363
25MP0002557_abnormal_social/conspecific_i1.99867751
26MP0006276_abnormal_autonomic_nervous1.96976720
27MP0003195_calcinosis1.96537091
28MP0008569_lethality_at_weaning1.94263610
29MP0001501_abnormal_sleep_pattern1.94145524
30MP0004811_abnormal_neuron_physiology1.90491854
31MP0004858_abnormal_nervous_system1.89589630
32MP0004885_abnormal_endolymph1.89023103
33MP0003329_amyloid_beta_deposits1.78771656
34MP0004924_abnormal_behavior1.77808728
35MP0005386_behavior/neurological_phenoty1.77808728
36MP0002909_abnormal_adrenal_gland1.72612466
37MP0000955_abnormal_spinal_cord1.69159821
38MP0006072_abnormal_retinal_apoptosis1.68468369
39MP0009780_abnormal_chondrocyte_physiolo1.68333031
40MP0002822_catalepsy1.65114930
41MP0005379_endocrine/exocrine_gland_phen1.52890363
42MP0002882_abnormal_neuron_morphology1.51619321
43MP0001986_abnormal_taste_sensitivity1.50219475
44MP0002066_abnormal_motor_capabilities/c1.49363411
45MP0000569_abnormal_digit_pigmentation1.44268733
46MP0003787_abnormal_imprinting1.42911047
47MP0002693_abnormal_pancreas_physiology1.41866027
48MP0001944_abnormal_pancreas_morphology1.41572585
49MP0001984_abnormal_olfaction1.39390713
50MP0005646_abnormal_pituitary_gland1.38966697
51MP0003879_abnormal_hair_cell1.37925404
52MP0004142_abnormal_muscle_tone1.37630771
53MP0005645_abnormal_hypothalamus_physiol1.34462721
54MP0005084_abnormal_gallbladder_morpholo1.31033510
55MP0003633_abnormal_nervous_system1.27796873
56MP0003122_maternal_imprinting1.27645992
57MP0002152_abnormal_brain_morphology1.26611649
58MP0003121_genomic_imprinting1.19625459
59MP0004043_abnormal_pH_regulation1.19559722
60MP0005253_abnormal_eye_physiology1.11238962
61MP0004133_heterotaxia1.10095513
62MP0003631_nervous_system_phenotype1.09814714
63MP0001502_abnormal_circadian_rhythm1.08865879
64MP0001529_abnormal_vocalization1.08260627
65MP0005448_abnormal_energy_balance1.07755106
66MP0002163_abnormal_gland_morphology1.07025163
67MP0001905_abnormal_dopamine_level1.06313799
68MP0004742_abnormal_vestibular_system1.06154204
69MP0001188_hyperpigmentation1.05851732
70MP0004145_abnormal_muscle_electrophysio1.02630104
71MP0000751_myopathy0.99638290
72MP0002928_abnormal_bile_duct0.99506428
73MP0002160_abnormal_reproductive_system0.99335442
74MP0002078_abnormal_glucose_homeostasis0.96913743
75MP0002069_abnormal_eating/drinking_beha0.95416225
76MP0008872_abnormal_physiological_respon0.94442489
77MP0010329_abnormal_lipoprotein_level0.92466579
78MP0002229_neurodegeneration0.92097387
79MP0003137_abnormal_impulse_conducting0.90296868
80MP0004147_increased_porphyrin_level0.89092269
81MP0002837_dystrophic_cardiac_calcinosis0.88750619
82MP0004085_abnormal_heartbeat0.88152200
83MP0001756_abnormal_urination0.87576300
84MP0003634_abnormal_glial_cell0.85307027
85MP0000631_abnormal_neuroendocrine_gland0.84531643
86MP0000639_abnormal_adrenal_gland0.84244510
87MP0003123_paternal_imprinting0.82803903
88MP0003632_abnormal_nervous_system0.82664606
89MP0002752_abnormal_somatic_nervous0.82623643
90MP0001963_abnormal_hearing_physiology0.81548276
91MP0005394_taste/olfaction_phenotype0.80899304
92MP0005499_abnormal_olfactory_system0.80899304
93MP0003953_abnormal_hormone_level0.78247953
94MP0003861_abnormal_nervous_system0.78110259
95MP0008874_decreased_physiological_sensi0.78080206
96MP0010386_abnormal_urinary_bladder0.77392912
97MP0000604_amyloidosis0.76049201
98MP0000427_abnormal_hair_cycle0.75732209
99MP0005409_darkened_coat_color0.75354268
100MP0003283_abnormal_digestive_organ0.75245171
101MP0005332_abnormal_amino_acid0.74895283
102MP0005389_reproductive_system_phenotype0.74867847
103MP0001177_atelectasis0.73963347
104MP0005535_abnormal_body_temperature0.71356823
105MP0002234_abnormal_pharynx_morphology0.70118512
106MP0002876_abnormal_thyroid_physiology0.69093991
107MP0004215_abnormal_myocardial_fiber0.68903605
108MP0005187_abnormal_penis_morphology0.67608972
109MP0000013_abnormal_adipose_tissue0.65343520
110MP0001485_abnormal_pinna_reflex0.64808038
111MP0002638_abnormal_pupillary_reflex0.62125190
112MP0005551_abnormal_eye_electrophysiolog0.61845074
113MP0000920_abnormal_myelination0.61710359
114MP0010769_abnormal_survival0.59939963
115MP0010770_preweaning_lethality0.59298751
116MP0002082_postnatal_lethality0.59298751
117MP0001299_abnormal_eye_distance/0.58236955
118MP0004510_myositis0.58116233
119MP0000026_abnormal_inner_ear0.56965479
120MP0010768_mortality/aging0.56201582
121MP0003075_altered_response_to0.55959364
122MP0003938_abnormal_ear_development0.55746744
123MP0004484_altered_response_of0.54589719
124MP0003956_abnormal_body_size0.54529278
125MP0001943_abnormal_respiration0.53764625
126MP0001664_abnormal_digestion0.52617716
127MP0002751_abnormal_autonomic_nervous0.52604718
128MP0003690_abnormal_glial_cell0.51922794

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.88137268
2Focal motor seizures (HP:0011153)6.72494382
3Focal seizures (HP:0007359)5.37011299
4Visual hallucinations (HP:0002367)5.30566833
5Progressive cerebellar ataxia (HP:0002073)4.97309665
6Action tremor (HP:0002345)4.40236158
7Epileptic encephalopathy (HP:0200134)4.39615454
8Atonic seizures (HP:0010819)4.19011944
9Febrile seizures (HP:0002373)4.01391906
10Broad-based gait (HP:0002136)3.91762791
11Absence seizures (HP:0002121)3.77236721
12Hyperventilation (HP:0002883)3.67615561
13Hypothermia (HP:0002045)3.65496552
14Generalized tonic-clonic seizures (HP:0002069)3.50111872
15Poor eye contact (HP:0000817)3.46771362
16Supranuclear gaze palsy (HP:0000605)3.44081795
17Mutism (HP:0002300)3.42469635
18Dialeptic seizures (HP:0011146)3.38048467
19Genetic anticipation (HP:0003743)3.37524229
20Gaze-evoked nystagmus (HP:0000640)3.36642281
21Depression (HP:0000716)3.34239663
22Ankle clonus (HP:0011448)3.32833127
23Truncal ataxia (HP:0002078)3.20446075
24Drooling (HP:0002307)3.14855391
25Excessive salivation (HP:0003781)3.14855391
26Impaired vibration sensation in the lower limbs (HP:0002166)3.12505721
27Dysdiadochokinesis (HP:0002075)3.10043444
28Hypoglycemic seizures (HP:0002173)3.09962418
29Intestinal atresia (HP:0011100)3.06568392
30Pheochromocytoma (HP:0002666)3.06106521
31Anxiety (HP:0000739)3.04750452
32Impaired social interactions (HP:0000735)3.03601015
33Abnormal social behavior (HP:0012433)3.03601015
34Abnormality of the lower motor neuron (HP:0002366)3.00854492
35Abnormal eating behavior (HP:0100738)3.00711437
36Scanning speech (HP:0002168)2.98176164
37Agitation (HP:0000713)2.94774304
38Amblyopia (HP:0000646)2.91739865
39Nephronophthisis (HP:0000090)2.91515740
40Amyotrophic lateral sclerosis (HP:0007354)2.91009004
41Large for gestational age (HP:0001520)2.90859599
42Ketoacidosis (HP:0001993)2.86890177
43Dysmetria (HP:0001310)2.85178095
44Impaired smooth pursuit (HP:0007772)2.84179726
45Papilledema (HP:0001085)2.82201626
46Abnormality of binocular vision (HP:0011514)2.80140370
47Diplopia (HP:0000651)2.80140370
48Urinary urgency (HP:0000012)2.79422974
49Hyperinsulinemic hypoglycemia (HP:0000825)2.75873121
50Hemiparesis (HP:0001269)2.74090069
51Limb dystonia (HP:0002451)2.72859743
52Urinary bladder sphincter dysfunction (HP:0002839)2.70212009
53Neuroendocrine neoplasm (HP:0100634)2.68339082
54Spastic gait (HP:0002064)2.68268016
55Cerebral inclusion bodies (HP:0100314)2.68258801
56Congenital stationary night blindness (HP:0007642)2.67294872
57Pancreatic fibrosis (HP:0100732)2.60676991
58Polyphagia (HP:0002591)2.59051549
59Progressive macrocephaly (HP:0004481)2.55793443
60Abnormality of the corticospinal tract (HP:0002492)2.53686642
61Aqueductal stenosis (HP:0002410)2.52898318
62Neurofibrillary tangles (HP:0002185)2.52436224
63Abnormality of ocular smooth pursuit (HP:0000617)2.49703706
64Epileptiform EEG discharges (HP:0011182)2.48946027
65Stereotypic behavior (HP:0000733)2.48525247
66Hemiplegia (HP:0002301)2.48091582
67Progressive inability to walk (HP:0002505)2.47797140
68Pancreatic cysts (HP:0001737)2.45947301
69Hyperglycemia (HP:0003074)2.45850213
70True hermaphroditism (HP:0010459)2.44852849
71Medial flaring of the eyebrow (HP:0010747)2.44798553
72EEG with generalized epileptiform discharges (HP:0011198)2.41952476
73Type II lissencephaly (HP:0007260)2.41524629
74Methylmalonic acidemia (HP:0002912)2.39164653
75Termporal pattern (HP:0011008)2.38468408
76Insidious onset (HP:0003587)2.38468408
77Torticollis (HP:0000473)2.37905194
78Intention tremor (HP:0002080)2.37809917
79Inappropriate behavior (HP:0000719)2.37750217
80Abnormality of midbrain morphology (HP:0002418)2.37341550
81Molar tooth sign on MRI (HP:0002419)2.37341550
82Abnormality of vitamin B metabolism (HP:0004340)2.37202332
83Acute necrotizing encephalopathy (HP:0006965)2.36140210
84Congenital sensorineural hearing impairment (HP:0008527)2.35645669
85Gait imbalance (HP:0002141)2.34910892
86Pendular nystagmus (HP:0012043)2.33932548
87Hypsarrhythmia (HP:0002521)2.33850124
88Abnormality of the renal medulla (HP:0100957)2.33106719
89Absent speech (HP:0001344)2.32964740
90Dysmetric saccades (HP:0000641)2.32803258
91Hypoglycemic coma (HP:0001325)2.31733476
92Focal dystonia (HP:0004373)2.28765213
93Postural instability (HP:0002172)2.26958029
94Abnormality of the renal cortex (HP:0011035)2.25271316
95Insomnia (HP:0100785)2.22183485
96Fetal akinesia sequence (HP:0001989)2.18119178
97Bradykinesia (HP:0002067)2.17441695
98Renal cortical cysts (HP:0000803)2.16990287
99Megalencephaly (HP:0001355)2.16152703
100Ketosis (HP:0001946)2.15094235
101Abnormal drinking behavior (HP:0030082)2.11127744
102Polydipsia (HP:0001959)2.11127744
103Prolonged QT interval (HP:0001657)2.10265041
104Muscular hypotonia of the trunk (HP:0008936)2.09500955
105Hypoplasia of the brainstem (HP:0002365)2.08020616
106Aplasia/Hypoplasia of the brainstem (HP:0007362)2.08020616
107Psychosis (HP:0000709)2.07889226
108Pointed chin (HP:0000307)2.07477864
109Akinesia (HP:0002304)2.05764220
110Abolished electroretinogram (ERG) (HP:0000550)2.05693638
111Gait ataxia (HP:0002066)2.04460274
112Impaired vibratory sensation (HP:0002495)2.04372784
113Abnormality of salivation (HP:0100755)2.04046831
114Apathy (HP:0000741)2.03201127
115Blue irides (HP:0000635)2.02849384
116Craniofacial dystonia (HP:0012179)2.02224365
117Mitochondrial inheritance (HP:0001427)2.01082744
118Insulin-resistant diabetes mellitus (HP:0000831)2.00481459
119Lower limb muscle weakness (HP:0007340)2.00107385
120Ventricular fibrillation (HP:0001663)1.99876286
121Abnormal mitochondria in muscle tissue (HP:0008316)1.99669971
122Narrow nasal bridge (HP:0000446)1.99635463
123Neoplasm of the peripheral nervous system (HP:0100007)1.99343414
124Abnormal rod and cone electroretinograms (HP:0008323)1.97576082
125Morphological abnormality of the pyramidal tract (HP:0002062)1.96942495
126Lissencephaly (HP:0001339)1.96379640
127Hypoventilation (HP:0002791)1.96042153
128Inability to walk (HP:0002540)1.95975124
129Failure to thrive in infancy (HP:0001531)1.95920095
130Bony spicule pigmentary retinopathy (HP:0007737)1.95671757
131Congenital primary aphakia (HP:0007707)1.95231898
132Severe muscular hypotonia (HP:0006829)1.93818332
133Poor suck (HP:0002033)1.92143415
134Hypomagnesemia (HP:0002917)1.90667954
135Incomplete penetrance (HP:0003829)1.89865370
136Generalized hypotonia (HP:0001290)1.89810879
137Status epilepticus (HP:0002133)1.89446620
138Pachygyria (HP:0001302)1.88141365
139Obstructive sleep apnea (HP:0002870)1.88103914
140Increased CSF lactate (HP:0002490)1.86254308
141Late onset (HP:0003584)1.85537889
142Lower limb asymmetry (HP:0100559)1.85354285
143Methylmalonic aciduria (HP:0012120)1.85312676
144Acute encephalopathy (HP:0006846)1.83356975
145Protruding tongue (HP:0010808)1.83341272
146Attenuation of retinal blood vessels (HP:0007843)1.83015978
147Hepatic necrosis (HP:0002605)1.82734987
148Abnormal EKG (HP:0003115)1.81793547
149Neuronal loss in central nervous system (HP:0002529)1.80862212
150Annular pancreas (HP:0001734)1.78657566
151Sporadic (HP:0003745)1.78282470
152Spastic tetraplegia (HP:0002510)1.78241883
153Nephrogenic diabetes insipidus (HP:0009806)1.76929352
154Chronic hepatic failure (HP:0100626)1.76556082
155Syncope (HP:0001279)1.75372250
156Furrowed tongue (HP:0000221)1.75301571
157Hepatocellular necrosis (HP:0001404)1.73365578
158Specific learning disability (HP:0001328)1.70586870
159Diminished movement (HP:0002374)1.68874965
160Abnormality of vitamin metabolism (HP:0100508)1.68136551
161Tongue fasciculations (HP:0001308)1.68064605
162Postural tremor (HP:0002174)1.66154740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.42192370
2MARK14.92564296
3NTRK34.41575642
4EPHA43.60567579
5MAP3K93.52925712
6MAP3K43.15119583
7MINK12.82518928
8MAP2K72.72907762
9DAPK22.30544753
10NTRK22.25408922
11MAP4K22.13386488
12ADRBK22.12366430
13MAP3K122.09995335
14CASK2.03373687
15PAK62.01901672
16MAPK132.01894197
17MAP2K42.01536819
18GRK11.90431262
19FGFR21.90277645
20PNCK1.64946247
21KSR11.61450364
22CAMKK11.60274029
23KSR21.59431651
24CDK51.53017328
25PRKD31.45997030
26SIK21.45379355
27INSRR1.43585318
28PLK21.43201007
29PHKG21.41227307
30PHKG11.41227307
31WNK41.40777802
32NTRK11.40437866
33DAPK11.38794560
34PRPF4B1.38648436
35RIPK41.38305666
36CSNK1G11.36092322
37UHMK11.28016718
38CDK191.27517424
39TNIK1.27140724
40PRKCG1.26602124
41GRK51.26117268
42LATS21.22330595
43BMPR1B1.21568756
44FES1.17485935
45STK38L1.14274346
46PINK11.09011249
47STK381.00643061
48CAMKK20.99150480
49CDK180.96790190
50TLK10.96462472
51SGK2230.95558412
52SGK4940.95558412
53WNK10.95062602
54CDK150.93965430
55CDK140.93411175
56CAMK2A0.92287100
57CSNK1G20.91097247
58DYRK20.90596710
59MAP3K20.89903632
60ERBB30.88557788
61EPHA30.88080983
62ALK0.87903823
63MAPKAPK30.87566680
64CAMK2B0.84607883
65CAMK10.84553131
66STK390.84350968
67AKT30.84091967
68SGK20.83537439
69MAP2K60.82587097
70CDK11A0.82411916
71DYRK1A0.82390259
72RET0.81816742
73TYRO30.80307820
74PRKCI0.79510095
75NLK0.77548862
76MAPKAPK50.76685331
77NME10.75982174
78MARK20.75467140
79LIMK10.73556529
80ZAK0.72729147
81PAK30.71883389
82STK110.71588129
83ARAF0.70409382
84TRIM280.69230515
85LMTK20.67383216
86SGK30.66900230
87TAOK10.66755405
88TRPM70.65845076
89YES10.65507075
90PRKCH0.65353189
91SGK10.64979699
92MAP3K60.63603085
93PRKCZ0.61434970
94PRKD20.59799292
95FER0.58994025
96PTK2B0.57762241
97BCR0.56924287
98PRKAA10.56361766
99CAMK1G0.55447889
100FGR0.55006090
101OXSR10.54961469
102MST40.53501960
103PRKCE0.52690013
104CDC42BPA0.52540656
105PDPK10.51764357
106RPS6KA20.51410977
107PDK10.50970011
108TNK20.50434273
109PRKACA0.50312616
110WNK30.49658282
111CSNK1A10.48297517
112CSNK1G30.46314547
113FYN0.45441050
114BMPR20.45389886
115RPS6KA30.45229182
116CAMK40.44044159
117TAOK30.42159000
118CSNK1D0.41064949
119ADRBK10.39748766
120CAMK2D0.39594466
121MAPK120.39259865
122MAP2K10.39175818
123PRKCA0.38268104
124PRKG10.36619401
125RAF10.36173375
126SIK30.35939403
127MAPK100.35559658
128CAMK2G0.34600848
129RIPK10.34519088
130FGFR30.34093912
131CSNK1A1L0.33670845
132CSNK1E0.33119339
133PRKCB0.32592271
134PKN10.32425379
135ROCK20.32128689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92455822
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.67870157
3Synaptic vesicle cycle_Homo sapiens_hsa047213.24603449
4Long-term potentiation_Homo sapiens_hsa047202.78976572
5Circadian entrainment_Homo sapiens_hsa047132.76316779
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71693646
7GABAergic synapse_Homo sapiens_hsa047272.70740484
8Glutamatergic synapse_Homo sapiens_hsa047242.70133356
9Olfactory transduction_Homo sapiens_hsa047402.66526716
10Morphine addiction_Homo sapiens_hsa050322.47178320
11Amphetamine addiction_Homo sapiens_hsa050312.43327081
12Butanoate metabolism_Homo sapiens_hsa006502.29526350
13Dopaminergic synapse_Homo sapiens_hsa047282.25730491
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23700426
15Salivary secretion_Homo sapiens_hsa049702.03842009
16Cholinergic synapse_Homo sapiens_hsa047251.94314056
17Oxidative phosphorylation_Homo sapiens_hsa001901.93592792
18Insulin secretion_Homo sapiens_hsa049111.92657607
19Taste transduction_Homo sapiens_hsa047421.92167393
20Long-term depression_Homo sapiens_hsa047301.84070029
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83954683
22Gastric acid secretion_Homo sapiens_hsa049711.79663164
23Serotonergic synapse_Homo sapiens_hsa047261.66000458
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61934768
25Cocaine addiction_Homo sapiens_hsa050301.61144868
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60396009
27Oxytocin signaling pathway_Homo sapiens_hsa049211.57844953
28Renin secretion_Homo sapiens_hsa049241.57324856
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56677531
30Protein export_Homo sapiens_hsa030601.56104256
31GnRH signaling pathway_Homo sapiens_hsa049121.49407972
32Gap junction_Homo sapiens_hsa045401.49071078
33Calcium signaling pathway_Homo sapiens_hsa040201.47541984
34Axon guidance_Homo sapiens_hsa043601.39595487
35Regulation of autophagy_Homo sapiens_hsa041401.34382077
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34272398
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32313326
38Sulfur metabolism_Homo sapiens_hsa009201.30918737
39Collecting duct acid secretion_Homo sapiens_hsa049661.30196048
40Type II diabetes mellitus_Homo sapiens_hsa049301.28602036
41Estrogen signaling pathway_Homo sapiens_hsa049151.26963701
42Selenocompound metabolism_Homo sapiens_hsa004501.22120617
43cAMP signaling pathway_Homo sapiens_hsa040241.18395243
44Parkinsons disease_Homo sapiens_hsa050121.17762158
45Glioma_Homo sapiens_hsa052141.17663359
46ErbB signaling pathway_Homo sapiens_hsa040121.13221837
47Ether lipid metabolism_Homo sapiens_hsa005651.07461910
48Melanogenesis_Homo sapiens_hsa049161.05786632
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03147728
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01874284
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98944511
52Linoleic acid metabolism_Homo sapiens_hsa005910.98448536
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98297499
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97746144
55Vibrio cholerae infection_Homo sapiens_hsa051100.97189366
56Tryptophan metabolism_Homo sapiens_hsa003800.96118771
57Vitamin B6 metabolism_Homo sapiens_hsa007500.94792956
58Oocyte meiosis_Homo sapiens_hsa041140.94329890
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93801230
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93285275
61Cardiac muscle contraction_Homo sapiens_hsa042600.92479266
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89209508
63Circadian rhythm_Homo sapiens_hsa047100.86259254
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84946481
65Dorso-ventral axis formation_Homo sapiens_hsa043200.84409406
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83515459
67Folate biosynthesis_Homo sapiens_hsa007900.82875634
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.80698223
69Peroxisome_Homo sapiens_hsa041460.80142893
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.79389655
71Choline metabolism in cancer_Homo sapiens_hsa052310.77767455
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77590489
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77342137
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75981195
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.75335430
76Pancreatic secretion_Homo sapiens_hsa049720.72490436
77Thyroid hormone synthesis_Homo sapiens_hsa049180.71961248
78ABC transporters_Homo sapiens_hsa020100.71865386
79MAPK signaling pathway_Homo sapiens_hsa040100.70834681
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68944835
81Endometrial cancer_Homo sapiens_hsa052130.67216016
82Fatty acid elongation_Homo sapiens_hsa000620.67021969
83Phototransduction_Homo sapiens_hsa047440.66951879
84Fatty acid metabolism_Homo sapiens_hsa012120.66880468
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.64723994
86Dilated cardiomyopathy_Homo sapiens_hsa054140.63451888
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.63389592
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63154710
89VEGF signaling pathway_Homo sapiens_hsa043700.60707425
90Mineral absorption_Homo sapiens_hsa049780.60036815
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59737865
92Alcoholism_Homo sapiens_hsa050340.58988483
93beta-Alanine metabolism_Homo sapiens_hsa004100.58867749
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58117482
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56315870
96Ras signaling pathway_Homo sapiens_hsa040140.56290261
97Huntingtons disease_Homo sapiens_hsa050160.56278294
98Renal cell carcinoma_Homo sapiens_hsa052110.55968533
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55011950
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54331659
101Alzheimers disease_Homo sapiens_hsa050100.53219268
102Glucagon signaling pathway_Homo sapiens_hsa049220.52792795
103mTOR signaling pathway_Homo sapiens_hsa041500.52699404
104Colorectal cancer_Homo sapiens_hsa052100.52374183
105Prion diseases_Homo sapiens_hsa050200.50568504
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.50491630
107Fatty acid biosynthesis_Homo sapiens_hsa000610.50149075
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50083302
109Wnt signaling pathway_Homo sapiens_hsa043100.49685048
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49502443
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49478477
112Basal transcription factors_Homo sapiens_hsa030220.48462440
113Insulin signaling pathway_Homo sapiens_hsa049100.47703761
114Propanoate metabolism_Homo sapiens_hsa006400.47617091
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46951654
116Rap1 signaling pathway_Homo sapiens_hsa040150.46816779
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46475614
118Endocytosis_Homo sapiens_hsa041440.46181248
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43505663
120Non-small cell lung cancer_Homo sapiens_hsa052230.43187567
121Type I diabetes mellitus_Homo sapiens_hsa049400.43041062
122Chemical carcinogenesis_Homo sapiens_hsa052040.42789128
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41595490
124Bile secretion_Homo sapiens_hsa049760.40955352
125Caffeine metabolism_Homo sapiens_hsa002320.38886885
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38347549
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37894217
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37244834
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36586628
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34953372
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.34922726
132Metabolic pathways_Homo sapiens_hsa011000.34544010
133Nitrogen metabolism_Homo sapiens_hsa009100.32991342
134Inositol phosphate metabolism_Homo sapiens_hsa005620.30206655
135Chemokine signaling pathway_Homo sapiens_hsa040620.29077148
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27725547
137Ovarian steroidogenesis_Homo sapiens_hsa049130.27411195
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27384228
139African trypanosomiasis_Homo sapiens_hsa051430.26809684
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25818442
141Prolactin signaling pathway_Homo sapiens_hsa049170.25290396

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