AMER2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.20038976
2neuron cell-cell adhesion (GO:0007158)5.04421351
3vocalization behavior (GO:0071625)4.54845774
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52355932
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50840698
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.45729688
7presynaptic membrane assembly (GO:0097105)4.43207311
8protein localization to synapse (GO:0035418)4.42758185
9synaptic vesicle exocytosis (GO:0016079)4.34960680
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34677533
11nucleobase catabolic process (GO:0046113)4.25494609
12presynaptic membrane organization (GO:0097090)4.18865257
13regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.07991582
14regulation of synaptic vesicle exocytosis (GO:2000300)4.03058141
15postsynaptic membrane organization (GO:0001941)3.98202939
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.92735039
17neuronal action potential propagation (GO:0019227)3.90267306
18synaptic vesicle maturation (GO:0016188)3.86571196
19locomotory exploration behavior (GO:0035641)3.85108626
20central nervous system neuron axonogenesis (GO:0021955)3.81835037
21regulation of glutamate receptor signaling pathway (GO:1900449)3.77740469
22glutamate receptor signaling pathway (GO:0007215)3.71459225
23central nervous system myelination (GO:0022010)3.70382852
24axon ensheathment in central nervous system (GO:0032291)3.70382852
25neuron recognition (GO:0008038)3.68355371
26layer formation in cerebral cortex (GO:0021819)3.67034773
27regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.65314103
28synaptic transmission, glutamatergic (GO:0035249)3.58155558
29retinal cone cell development (GO:0046549)3.52092394
30regulation of synaptic vesicle transport (GO:1902803)3.51825870
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48631018
32neurotransmitter-gated ion channel clustering (GO:0072578)3.47468947
33neuron-neuron synaptic transmission (GO:0007270)3.47032302
34cell migration in hindbrain (GO:0021535)3.45561341
35gamma-aminobutyric acid transport (GO:0015812)3.44162505
36glutamate secretion (GO:0014047)3.44159461
37positive regulation of synaptic transmission, GABAergic (GO:0032230)3.41355635
38neurotransmitter secretion (GO:0007269)3.38309668
39sodium ion export (GO:0071436)3.32655671
40negative regulation of synaptic transmission, GABAergic (GO:0032229)3.32036899
41axonal fasciculation (GO:0007413)3.31613256
42auditory behavior (GO:0031223)3.27968642
43limb bud formation (GO:0060174)3.27678304
44cerebellar granule cell differentiation (GO:0021707)3.23012970
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.22927415
46long-chain fatty acid biosynthetic process (GO:0042759)3.22434813
47C4-dicarboxylate transport (GO:0015740)3.20930786
48glycosphingolipid biosynthetic process (GO:0006688)3.20302536
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.20294765
50regulation of respiratory system process (GO:0044065)3.19985812
51positive regulation of membrane potential (GO:0045838)3.19971587
52acidic amino acid transport (GO:0015800)3.19822067
53transmission of nerve impulse (GO:0019226)3.19617095
54dendritic spine morphogenesis (GO:0060997)3.19510968
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18831852
56amino acid import (GO:0043090)3.18822817
57positive regulation of dendritic spine morphogenesis (GO:0061003)3.18746777
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17922162
59exploration behavior (GO:0035640)3.16829317
60dendrite morphogenesis (GO:0048813)3.16534456
61regulation of vesicle fusion (GO:0031338)3.14611170
62proline transport (GO:0015824)3.14223367
63regulation of postsynaptic membrane potential (GO:0060078)3.13943885
64membrane hyperpolarization (GO:0060081)3.12823180
65regulation of synapse structural plasticity (GO:0051823)3.12002965
66response to auditory stimulus (GO:0010996)3.11089585
67negative regulation of axonogenesis (GO:0050771)3.11066267
68neurotransmitter uptake (GO:0001504)3.10871886
69cellular potassium ion homeostasis (GO:0030007)3.10128261
70long-term memory (GO:0007616)3.09040757
71regulation of collateral sprouting (GO:0048670)3.07883823
72neurotransmitter transport (GO:0006836)3.06488441
73regulation of neuronal synaptic plasticity (GO:0048168)3.05658247
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05645858
75positive regulation of synapse assembly (GO:0051965)3.03829995
76regulation of neurotransmitter secretion (GO:0046928)3.01354006
77membrane assembly (GO:0071709)3.01266612
78innervation (GO:0060384)2.99545156
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.99114553
80synapse assembly (GO:0007416)2.98131998
81negative regulation of axon extension (GO:0030517)2.97974341
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.97741029
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96203762
84mitochondrion transport along microtubule (GO:0047497)2.95945320
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.95945320
86adult walking behavior (GO:0007628)2.95083706
87positive regulation of potassium ion transmembrane transport (GO:1901381)2.94514774
88startle response (GO:0001964)2.93647416
89L-glutamate transport (GO:0015813)2.93148426
90mechanosensory behavior (GO:0007638)2.91345659
91regulation of respiratory gaseous exchange (GO:0043576)2.89250091
92axonogenesis (GO:0007409)2.88828542
93membrane depolarization during action potential (GO:0086010)2.88549259
94synaptic vesicle endocytosis (GO:0048488)2.88504161
95cerebral cortex radially oriented cell migration (GO:0021799)2.87075583
96potassium ion import (GO:0010107)2.85011613
97L-amino acid import (GO:0043092)2.84256791
98membrane depolarization (GO:0051899)2.83778369
99mating behavior (GO:0007617)2.83688127
100regulation of dendritic spine morphogenesis (GO:0061001)2.83062638
101positive regulation of synapse maturation (GO:0090129)2.81708515
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.80172036
103regulation of neurotransmitter transport (GO:0051588)2.80046109
104calcium ion-dependent exocytosis (GO:0017156)2.73997259
105positive regulation of dendritic spine development (GO:0060999)2.73705450
106regulation of synaptic transmission, GABAergic (GO:0032228)2.73042392
107cerebellar Purkinje cell differentiation (GO:0021702)2.72707520
108neuronal ion channel clustering (GO:0045161)2.71939917
109photoreceptor cell differentiation (GO:0046530)2.70252413
110eye photoreceptor cell differentiation (GO:0001754)2.70252413
111regulation of neurotransmitter levels (GO:0001505)2.69272670
112learning (GO:0007612)2.68559365
113establishment of mitochondrion localization (GO:0051654)2.64995226
114long-term synaptic potentiation (GO:0060291)2.62664481
115synapse organization (GO:0050808)2.61503832
116synaptic vesicle docking involved in exocytosis (GO:0016081)2.60915622
117adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59850253
118adult behavior (GO:0030534)2.59405358
119central nervous system projection neuron axonogenesis (GO:0021952)2.57955847
120regulation of voltage-gated calcium channel activity (GO:1901385)2.57468489
121regulation of dendritic spine development (GO:0060998)2.56551315
122regulation of synaptic plasticity (GO:0048167)2.55080214
123negative regulation of dendrite development (GO:2000171)2.54904638
124regulation of synapse assembly (GO:0051963)2.54690423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60226491
2GBX2_23144817_ChIP-Seq_PC3_Human3.61672113
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98124354
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88293481
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.85735262
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57430599
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57430599
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.55477233
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53441751
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49127616
11REST_21632747_ChIP-Seq_MESCs_Mouse2.45724682
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45368037
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45133673
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.41498036
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35235085
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34712001
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.30534233
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29889073
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21631965
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.14704611
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.97598559
22DROSHA_22980978_ChIP-Seq_HELA_Human1.96783573
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93221689
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88042827
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.87907669
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87180659
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.84798309
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.82073267
29TAF15_26573619_Chip-Seq_HEK293_Human1.81561678
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78093591
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77095933
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76533530
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75445556
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74505771
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73001668
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67797186
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63408479
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58354390
39AR_21572438_ChIP-Seq_LNCaP_Human1.57249884
40SMAD4_21799915_ChIP-Seq_A2780_Human1.56855132
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54556291
42P300_19829295_ChIP-Seq_ESCs_Human1.50269995
43RNF2_27304074_Chip-Seq_NSC_Mouse1.48705973
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45318183
45VDR_22108803_ChIP-Seq_LS180_Human1.42295599
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41027772
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40867415
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39777512
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39139448
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.37009752
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36348805
52EWS_26573619_Chip-Seq_HEK293_Human1.36326311
53IGF1R_20145208_ChIP-Seq_DFB_Human1.34834876
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31460597
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30863608
56SOX9_26525672_Chip-Seq_HEART_Mouse1.30077320
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.29200855
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.27538696
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24430730
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24200234
61ZNF274_21170338_ChIP-Seq_K562_Hela1.22511485
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.22455778
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17071004
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16821227
65TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16742117
66AR_25329375_ChIP-Seq_VCAP_Human1.15822197
67STAT3_23295773_ChIP-Seq_U87_Human1.15601717
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14885608
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14885608
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14854871
71CBP_20019798_ChIP-Seq_JUKART_Human1.14812690
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14812690
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.14572156
74TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13218245
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.13122214
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12387727
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09682772
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09547852
79ER_23166858_ChIP-Seq_MCF-7_Human1.08164326
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07338835
81TCF4_23295773_ChIP-Seq_U87_Human1.05682953
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05323613
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04806216
84P53_22387025_ChIP-Seq_ESCs_Mouse1.04490724
85BCAT_22108803_ChIP-Seq_LS180_Human1.03906788
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03254830
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02897860
88TP53_16413492_ChIP-PET_HCT116_Human1.02793330
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02353804
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02121291
91RUNX2_22187159_ChIP-Seq_PCA_Human1.01924525
92AR_19668381_ChIP-Seq_PC3_Human1.01770142
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.01428105
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01045707
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.00329403
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99966590
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.99382860
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.96344595
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96291274
100FUS_26573619_Chip-Seq_HEK293_Human0.95716896
101KDM2B_26808549_Chip-Seq_REH_Human0.95402301
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94950157
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94693019
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.91477160
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.91231627
106VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89311787
107AHR_22903824_ChIP-Seq_MCF-7_Human0.88913781
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.88732903
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88417881
110OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86545585
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86539332
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.86183026
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86102515
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85561079
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84759420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.24799245
2MP0004859_abnormal_synaptic_plasticity4.15372224
3MP0004270_analgesia3.51460891
4MP0003635_abnormal_synaptic_transmissio3.29100187
5MP0005423_abnormal_somatic_nervous3.26682475
6MP0001968_abnormal_touch/_nociception2.90137747
7MP0009745_abnormal_behavioral_response2.85185105
8MP0009046_muscle_twitch2.78697504
9MP0002064_seizures2.72927495
10MP0002063_abnormal_learning/memory/cond2.72777326
11MP0002734_abnormal_mechanical_nocicepti2.68703587
12MP0002272_abnormal_nervous_system2.60118246
13MP0001486_abnormal_startle_reflex2.56767260
14MP0002735_abnormal_chemical_nociception2.49569564
15MP0005551_abnormal_eye_electrophysiolog2.48511597
16MP0002572_abnormal_emotion/affect_behav2.46148361
17MP0002736_abnormal_nociception_after2.34567418
18MP0000778_abnormal_nervous_system2.23620399
19MP0006276_abnormal_autonomic_nervous2.20095305
20MP0002733_abnormal_thermal_nociception2.05161214
21MP0002067_abnormal_sensory_capabilities2.03136841
22MP0002184_abnormal_innervation2.02753272
23MP0001970_abnormal_pain_threshold1.97233339
24MP0006072_abnormal_retinal_apoptosis1.93416266
25MP0000569_abnormal_digit_pigmentation1.89982367
26MP0001529_abnormal_vocalization1.89139628
27MP0001440_abnormal_grooming_behavior1.88925184
28MP0001984_abnormal_olfaction1.85695965
29MP0005645_abnormal_hypothalamus_physiol1.84838996
30MP0004885_abnormal_endolymph1.77612576
31MP0001502_abnormal_circadian_rhythm1.76081239
32MP0002638_abnormal_pupillary_reflex1.73677123
33MP0002822_catalepsy1.71760630
34MP0002557_abnormal_social/conspecific_i1.71221976
35MP0001501_abnormal_sleep_pattern1.69703353
36MP0004742_abnormal_vestibular_system1.68864765
37MP0002882_abnormal_neuron_morphology1.65841971
38MP0005253_abnormal_eye_physiology1.60901292
39MP0003787_abnormal_imprinting1.60137949
40MP0000955_abnormal_spinal_cord1.58226616
41MP0004142_abnormal_muscle_tone1.54690195
42MP0001905_abnormal_dopamine_level1.53839487
43MP0005386_behavior/neurological_phenoty1.52690897
44MP0004924_abnormal_behavior1.52690897
45MP0005410_abnormal_fertilization1.52660768
46MP0008569_lethality_at_weaning1.51042785
47MP0005646_abnormal_pituitary_gland1.48687650
48MP0001177_atelectasis1.43736986
49MP0004811_abnormal_neuron_physiology1.43418267
50MP0002229_neurodegeneration1.42466896
51MP0006292_abnormal_olfactory_placode1.42464652
52MP0003329_amyloid_beta_deposits1.42417966
53MP0000920_abnormal_myelination1.41881025
54MP0002066_abnormal_motor_capabilities/c1.35000797
55MP0004858_abnormal_nervous_system1.33546411
56MP0002752_abnormal_somatic_nervous1.32913530
57MP0003634_abnormal_glial_cell1.30178142
58MP0001986_abnormal_taste_sensitivity1.28779778
59MP0003122_maternal_imprinting1.27856864
60MP0001188_hyperpigmentation1.26266395
61MP0002234_abnormal_pharynx_morphology1.25730049
62MP0010386_abnormal_urinary_bladder1.24826900
63MP0009780_abnormal_chondrocyte_physiolo1.23847829
64MP0000631_abnormal_neuroendocrine_gland1.21106721
65MP0002152_abnormal_brain_morphology1.17559632
66MP0005499_abnormal_olfactory_system1.17006254
67MP0005394_taste/olfaction_phenotype1.17006254
68MP0002909_abnormal_adrenal_gland1.16856763
69MP0003011_delayed_dark_adaptation1.16803294
70MP0003633_abnormal_nervous_system1.14497543
71MP0003879_abnormal_hair_cell1.13905078
72MP0005187_abnormal_penis_morphology1.10207652
73MP0005195_abnormal_posterior_eye1.09844572
74MP0001963_abnormal_hearing_physiology1.06489036
75MP0005409_darkened_coat_color1.05126125
76MP0000566_synostosis1.05119074
77MP0003631_nervous_system_phenotype1.00976992
78MP0008877_abnormal_DNA_methylation0.98034762
79MP0002102_abnormal_ear_morphology0.95501223
80MP0001346_abnormal_lacrimal_gland0.94099549
81MP0003121_genomic_imprinting0.93005455
82MP0001299_abnormal_eye_distance/0.92790729
83MP0000026_abnormal_inner_ear0.90564241
84MP0002653_abnormal_ependyma_morphology0.90057273
85MP0002837_dystrophic_cardiac_calcinosis0.88188882
86MP0008789_abnormal_olfactory_epithelium0.86967887
87MP0002751_abnormal_autonomic_nervous0.86859274
88MP0003690_abnormal_glial_cell0.86760936
89MP0002090_abnormal_vision0.85749951
90MP0004043_abnormal_pH_regulation0.84739664
91MP0002069_abnormal_eating/drinking_beha0.83996577
92MP0001485_abnormal_pinna_reflex0.82699694
93MP0005248_abnormal_Harderian_gland0.82441081
94MP0003632_abnormal_nervous_system0.81764526
95MP0003137_abnormal_impulse_conducting0.80477094
96MP0005171_absent_coat_pigmentation0.77748653
97MP0003698_abnormal_male_reproductive0.77184000
98MP0004133_heterotaxia0.74846565
99MP0000516_abnormal_urinary_system0.74810165
100MP0005367_renal/urinary_system_phenotyp0.74810165
101MP0004085_abnormal_heartbeat0.74332549
102MP0003861_abnormal_nervous_system0.73824383
103MP0003119_abnormal_digestive_system0.70715139
104MP0002082_postnatal_lethality0.69293731
105MP0010770_preweaning_lethality0.69293731
106MP0003890_abnormal_embryonic-extraembry0.68013202
107MP0010769_abnormal_survival0.67869915
108MP0004147_increased_porphyrin_level0.66244764
109MP0005391_vision/eye_phenotype0.65729715
110MP0004145_abnormal_muscle_electrophysio0.65424608
111MP0000647_abnormal_sebaceous_gland0.65236824
112MP0008872_abnormal_physiological_respon0.65022664
113MP0010768_mortality/aging0.64361785
114MP0005379_endocrine/exocrine_gland_phen0.64198002
115MP0001943_abnormal_respiration0.63811069
116MP0003950_abnormal_plasma_membrane0.63211559
117MP0003283_abnormal_digestive_organ0.63057705
118MP0000751_myopathy0.61348167
119MP0003183_abnormal_peptide_metabolism0.60949163
120MP0003938_abnormal_ear_development0.60161554
121MP0001664_abnormal_digestion0.59298982
122MP0005535_abnormal_body_temperature0.58884050

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.32718589
2Myokymia (HP:0002411)5.32113303
3Focal seizures (HP:0007359)4.13480838
4Epileptic encephalopathy (HP:0200134)4.05490351
5Progressive cerebellar ataxia (HP:0002073)3.75372291
6Congenital stationary night blindness (HP:0007642)3.48094123
7Hyperventilation (HP:0002883)3.45560098
8Febrile seizures (HP:0002373)3.41692537
9Atonic seizures (HP:0010819)3.32500900
10Visual hallucinations (HP:0002367)3.31839839
11Central scotoma (HP:0000603)3.20895459
12Action tremor (HP:0002345)3.18909152
13Supranuclear gaze palsy (HP:0000605)3.17438676
14Limb dystonia (HP:0002451)3.12692893
15Neurofibrillary tangles (HP:0002185)3.10305250
16Abnormal rod and cone electroretinograms (HP:0008323)3.06652620
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.05360583
18Absent/shortened dynein arms (HP:0200106)3.05360583
19Absence seizures (HP:0002121)2.92119973
20Hemiparesis (HP:0001269)2.90401875
21Abnormality of macular pigmentation (HP:0008002)2.89800969
22Decreased central vision (HP:0007663)2.86286261
23Dialeptic seizures (HP:0011146)2.84239773
24Bony spicule pigmentary retinopathy (HP:0007737)2.79722652
25Generalized tonic-clonic seizures (HP:0002069)2.77025848
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70891493
27Ankle clonus (HP:0011448)2.68172121
28Abnormality of the corticospinal tract (HP:0002492)2.67946193
29Gait imbalance (HP:0002141)2.66801504
30Abnormal social behavior (HP:0012433)2.65229047
31Impaired social interactions (HP:0000735)2.65229047
32Amblyopia (HP:0000646)2.64088890
33Broad-based gait (HP:0002136)2.63297748
34Dysmetria (HP:0001310)2.59552579
35Amyotrophic lateral sclerosis (HP:0007354)2.59048337
36Protruding tongue (HP:0010808)2.59015989
37Truncal ataxia (HP:0002078)2.58541904
38Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.52660572
39Abnormality of the labia minora (HP:0012880)2.52548167
40Dysdiadochokinesis (HP:0002075)2.51567874
41Spastic gait (HP:0002064)2.50248396
42Megalencephaly (HP:0001355)2.49202223
43Degeneration of the lateral corticospinal tracts (HP:0002314)2.47980689
44Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47980689
45Urinary urgency (HP:0000012)2.46302866
46Cerebral inclusion bodies (HP:0100314)2.44490827
47Scotoma (HP:0000575)2.42586800
48Depression (HP:0000716)2.41782044
49Pheochromocytoma (HP:0002666)2.40416299
50Diplopia (HP:0000651)2.37932653
51Abnormality of binocular vision (HP:0011514)2.37932653
52Medial flaring of the eyebrow (HP:0010747)2.37747329
53Retinal dysplasia (HP:0007973)2.34852688
54Anxiety (HP:0000739)2.34448094
55Absent speech (HP:0001344)2.34393328
56Gaze-evoked nystagmus (HP:0000640)2.28297195
57Congenital primary aphakia (HP:0007707)2.25351108
58Genital tract atresia (HP:0001827)2.25325525
59Inability to walk (HP:0002540)2.23953926
60Vaginal atresia (HP:0000148)2.23798703
61Epileptiform EEG discharges (HP:0011182)2.21685638
62Abnormal respiratory motile cilium physiology (HP:0012261)2.21608931
63Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.19090204
64Excessive salivation (HP:0003781)2.18809754
65Drooling (HP:0002307)2.18809754
66Hepatoblastoma (HP:0002884)2.18626717
67EEG with generalized epileptiform discharges (HP:0011198)2.18390039
68Alacrima (HP:0000522)2.17854886
69Hemiplegia (HP:0002301)2.17721140
70Abnormal eating behavior (HP:0100738)2.17315707
71Abolished electroretinogram (ERG) (HP:0000550)2.16781784
72Polyphagia (HP:0002591)2.16434546
73Specific learning disability (HP:0001328)2.13699419
74Dyschromatopsia (HP:0007641)2.13473213
75Abnormal ciliary motility (HP:0012262)2.13187557
76Severe visual impairment (HP:0001141)2.12914392
77Postural instability (HP:0002172)2.12551004
78Keratoconus (HP:0000563)2.11901119
79Increased corneal curvature (HP:0100692)2.11901119
80Aplasia involving bones of the extremities (HP:0009825)2.10934961
81Aplasia involving bones of the upper limbs (HP:0009823)2.10934961
82Aplasia of the phalanges of the hand (HP:0009802)2.10934961
83Neuroendocrine neoplasm (HP:0100634)2.09401383
84Attenuation of retinal blood vessels (HP:0007843)2.09055446
85Thickened helices (HP:0000391)2.09006754
86Choroideremia (HP:0001139)2.08611703
87Scanning speech (HP:0002168)2.08273618
88Peripheral hypomyelination (HP:0007182)2.08156589
89Status epilepticus (HP:0002133)2.05533023
90Abnormal respiratory motile cilium morphology (HP:0005938)2.05148826
91Abnormal respiratory epithelium morphology (HP:0012253)2.05148826
92Insidious onset (HP:0003587)2.03380971
93Termporal pattern (HP:0011008)2.03380971
94Septo-optic dysplasia (HP:0100842)2.02422141
95Intestinal atresia (HP:0011100)2.02102732
96Nephrogenic diabetes insipidus (HP:0009806)2.01728953
97Impaired vibration sensation in the lower limbs (HP:0002166)2.01410432
98Lissencephaly (HP:0001339)2.01094326
99Hypsarrhythmia (HP:0002521)1.99605334
100Abnormality of the lower motor neuron (HP:0002366)1.99436224
101Inappropriate behavior (HP:0000719)1.98510404
102Hypoplasia of the corpus callosum (HP:0002079)1.98067540
103Intention tremor (HP:0002080)1.97576749
104Genetic anticipation (HP:0003743)1.97432088
105Abnormality of salivation (HP:0100755)1.96791952
106Tented upper lip vermilion (HP:0010804)1.95760877
107Optic nerve hypoplasia (HP:0000609)1.95213440
108Hyperthyroidism (HP:0000836)1.94046915
109Agitation (HP:0000713)1.91349573
110Poor eye contact (HP:0000817)1.90039925
111Aplasia/Hypoplasia of the brainstem (HP:0007362)1.89938001
112Hypoplasia of the brainstem (HP:0002365)1.89938001
113Sensory axonal neuropathy (HP:0003390)1.88991808
114Widely spaced teeth (HP:0000687)1.88734033
115Rhinitis (HP:0012384)1.88300280
116Hypoventilation (HP:0002791)1.88114844
117Delusions (HP:0000746)1.88105254
118Pachygyria (HP:0001302)1.86810094
119Urinary bladder sphincter dysfunction (HP:0002839)1.86713306
120Chorioretinal atrophy (HP:0000533)1.86637391
121Decreased lacrimation (HP:0000633)1.86201453
122Progressive inability to walk (HP:0002505)1.86183382
123Exotropia (HP:0000577)1.85793525
124Lower limb muscle weakness (HP:0007340)1.85549518
125Mutism (HP:0002300)1.85260788
126Failure to thrive in infancy (HP:0001531)1.84963139
127Ulnar claw (HP:0001178)1.84902895
128Cerebral hypomyelination (HP:0006808)1.84622959
129Cutaneous finger syndactyly (HP:0010554)1.83516164
130Morphological abnormality of the pyramidal tract (HP:0002062)1.83481078
131Oligodactyly (hands) (HP:0001180)1.82213594
132Akinesia (HP:0002304)1.80054226
133Spastic tetraparesis (HP:0001285)1.76855477
134Intellectual disability, severe (HP:0010864)1.76742724
135Split foot (HP:0001839)1.75587048
136Vitreoretinal degeneration (HP:0000655)1.75165997
137Stereotypic behavior (HP:0000733)1.72811078
138Astrocytoma (HP:0009592)1.71761557
139Abnormality of the astrocytes (HP:0100707)1.71761557
140Spastic tetraplegia (HP:0002510)1.69708888
141Gastroesophageal reflux (HP:0002020)1.69041541
142Type II lissencephaly (HP:0007260)1.68408065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.64201157
2CASK3.39674050
3NTRK33.18602978
4EPHA42.89165688
5NTRK22.67025223
6MAP2K72.38364215
7FRK2.37841366
8MAP3K42.31686872
9MAP3K92.15029984
10PNCK2.08810758
11NTRK11.98938611
12PRPF4B1.98424046
13MINK11.95381616
14PAK61.90153029
15STK391.83461760
16TNIK1.82203485
17MAPK131.74673832
18UHMK11.68324643
19MAP4K21.64649898
20SGK4941.61541489
21SGK2231.61541489
22OXSR11.53334457
23GRK51.50487042
24CDK51.47374195
25MAP3K121.42407691
26MAP2K41.41443435
27CDK191.39919687
28FGR1.37492697
29LIMK11.33747742
30PHKG21.29853393
31PHKG11.29853393
32PRKD31.28929201
33RIPK41.28261032
34SIK21.26046261
35NEK61.22833198
36BCR1.20575897
37PKN11.19447652
38DAPK21.19418301
39PRKCG1.14413016
40CSNK1G21.14126699
41DYRK21.08976931
42CAMK2A1.08447249
43KSR11.04307576
44WNK41.04262311
45WNK11.03158109
46FES1.01504061
47CAMK2B1.01147324
48BMPR1B1.00322577
49CAMK1G0.95253758
50CSNK1G30.94831468
51KSR20.93774416
52DYRK1A0.93062598
53PLK20.91441290
54CDK140.89994052
55FGFR20.89872565
56CDK180.88820210
57CDK150.85969678
58PINK10.83543406
59GRK10.83267771
60PTK2B0.83016470
61SGK20.82932370
62TYRO30.81858870
63CAMKK20.79674758
64WNK30.79254742
65MARK20.77593835
66CDK11A0.76780832
67CAMKK10.76633224
68CSNK1A1L0.74645097
69YES10.72898367
70ROCK20.72557405
71CAMK2D0.70524269
72PRKCE0.70282577
73CAMK40.69084988
74IRAK20.66969232
75PAK30.66688451
76MAP3K20.66460286
77ADRBK10.65941636
78ERBB30.65186228
79MUSK0.64826789
80TRIM280.64216595
81ICK0.64151777
82STK380.64133103
83MKNK20.63419486
84SGK10.62206135
85ROCK10.60585227
86CSNK1D0.59962388
87CSNK1G10.57817023
88PRKCH0.56675401
89ADRBK20.56472383
90CDC42BPA0.56001187
91PRKCZ0.55821413
92SGK30.55161764
93MAPK100.54539234
94RPS6KA30.53999916
95GRK70.53963973
96FYN0.53923097
97STK110.53218338
98CAMK2G0.53000070
99MET0.52886499
100EPHB20.52639803
101ARAF0.52317484
102CAMK10.51903218
103BMPR20.50398239
104CDK30.49910106
105MAPK150.49779509
106RET0.49753807
107PDPK10.49588977
108CCNB10.48859795
109CSNK1A10.47212638
110MAPKAPK50.46936277
111INSRR0.46862516
112PRKG10.44174923
113AKT30.44082985
114PRKACA0.43383861
115ERBB20.42436660
116LATS20.41491204
117EPHA30.39585145
118DAPK10.38186154
119MAPK80.37207812
120GSK3B0.36515506
121PRKCB0.34223366
122CSNK1E0.32995606
123RPS6KB10.30402740

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59794068
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07432049
3Phototransduction_Homo sapiens_hsa047442.96318731
4GABAergic synapse_Homo sapiens_hsa047272.84605895
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67841974
6Morphine addiction_Homo sapiens_hsa050322.61870596
7Glutamatergic synapse_Homo sapiens_hsa047242.59249236
8Circadian entrainment_Homo sapiens_hsa047132.51951905
9Olfactory transduction_Homo sapiens_hsa047402.36412124
10Dopaminergic synapse_Homo sapiens_hsa047282.11097123
11Amphetamine addiction_Homo sapiens_hsa050312.06843311
12Serotonergic synapse_Homo sapiens_hsa047262.02407080
13Insulin secretion_Homo sapiens_hsa049112.00867313
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97605503
15Salivary secretion_Homo sapiens_hsa049701.97014043
16Long-term potentiation_Homo sapiens_hsa047201.93138324
17Taste transduction_Homo sapiens_hsa047421.92889902
18Cholinergic synapse_Homo sapiens_hsa047251.85444315
19Cocaine addiction_Homo sapiens_hsa050301.82724038
20Renin secretion_Homo sapiens_hsa049241.71351193
21Collecting duct acid secretion_Homo sapiens_hsa049661.68932223
22Long-term depression_Homo sapiens_hsa047301.66527206
23Axon guidance_Homo sapiens_hsa043601.58215504
24Gastric acid secretion_Homo sapiens_hsa049711.53244468
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52962785
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44634861
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44243289
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42617505
29Calcium signaling pathway_Homo sapiens_hsa040201.37299713
30Oxytocin signaling pathway_Homo sapiens_hsa049211.31767435
31Gap junction_Homo sapiens_hsa045401.25504990
32Vibrio cholerae infection_Homo sapiens_hsa051101.24792012
33Cardiac muscle contraction_Homo sapiens_hsa042601.24447724
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19021004
35GnRH signaling pathway_Homo sapiens_hsa049121.15405909
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14065119
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11513288
38cAMP signaling pathway_Homo sapiens_hsa040241.08168048
39Oxidative phosphorylation_Homo sapiens_hsa001901.01485181
40Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98096294
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97960660
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.95110378
43Melanogenesis_Homo sapiens_hsa049160.94470373
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93631603
45Type II diabetes mellitus_Homo sapiens_hsa049300.92743717
46Estrogen signaling pathway_Homo sapiens_hsa049150.92589791
47ErbB signaling pathway_Homo sapiens_hsa040120.92510709
48Dorso-ventral axis formation_Homo sapiens_hsa043200.89633840
49Alzheimers disease_Homo sapiens_hsa050100.89507804
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.89331426
51cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88576265
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86110378
53Pancreatic secretion_Homo sapiens_hsa049720.85512935
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84446672
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83942235
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78228960
57Histidine metabolism_Homo sapiens_hsa003400.76942979
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76073074
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75796263
60Alcoholism_Homo sapiens_hsa050340.74777757
61Parkinsons disease_Homo sapiens_hsa050120.71222285
62Choline metabolism in cancer_Homo sapiens_hsa052310.69802528
63Steroid biosynthesis_Homo sapiens_hsa001000.69566078
64Thyroid hormone synthesis_Homo sapiens_hsa049180.67848277
65beta-Alanine metabolism_Homo sapiens_hsa004100.65952904
66Ether lipid metabolism_Homo sapiens_hsa005650.65938380
67Glioma_Homo sapiens_hsa052140.63997593
68Ras signaling pathway_Homo sapiens_hsa040140.63486225
69Circadian rhythm_Homo sapiens_hsa047100.62077053
70MAPK signaling pathway_Homo sapiens_hsa040100.61887142
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60630542
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59355914
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.58213545
74Wnt signaling pathway_Homo sapiens_hsa043100.58119230
75Renal cell carcinoma_Homo sapiens_hsa052110.55903825
76Hedgehog signaling pathway_Homo sapiens_hsa043400.55324123
77Dilated cardiomyopathy_Homo sapiens_hsa054140.54952510
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54190864
79Ovarian steroidogenesis_Homo sapiens_hsa049130.51394681
80Hippo signaling pathway_Homo sapiens_hsa043900.50668437
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.50227769
82Oocyte meiosis_Homo sapiens_hsa041140.49811083
83Nitrogen metabolism_Homo sapiens_hsa009100.48477506
84Huntingtons disease_Homo sapiens_hsa050160.46829215
85Endocytosis_Homo sapiens_hsa041440.46599192
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46119072
87Endometrial cancer_Homo sapiens_hsa052130.46083520
88ABC transporters_Homo sapiens_hsa020100.45145273
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.44962613
90Inositol phosphate metabolism_Homo sapiens_hsa005620.44222240
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43698145
92Tight junction_Homo sapiens_hsa045300.42920748
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41597502
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41315423
95Rap1 signaling pathway_Homo sapiens_hsa040150.40416351
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39651992
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39011824
98Fatty acid elongation_Homo sapiens_hsa000620.38777170
99mTOR signaling pathway_Homo sapiens_hsa041500.37968781
100Type I diabetes mellitus_Homo sapiens_hsa049400.37674171
101Rheumatoid arthritis_Homo sapiens_hsa053230.37503395
102VEGF signaling pathway_Homo sapiens_hsa043700.36498564
103Linoleic acid metabolism_Homo sapiens_hsa005910.35985619
104Sphingolipid metabolism_Homo sapiens_hsa006000.35824902
105Propanoate metabolism_Homo sapiens_hsa006400.35715358
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35536859
107Prion diseases_Homo sapiens_hsa050200.35430186
108Glucagon signaling pathway_Homo sapiens_hsa049220.35331631
109Bile secretion_Homo sapiens_hsa049760.35109542
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33337525
111Phagosome_Homo sapiens_hsa041450.33334235
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32913498
113Butanoate metabolism_Homo sapiens_hsa006500.32681260
114Regulation of autophagy_Homo sapiens_hsa041400.32168799
115AMPK signaling pathway_Homo sapiens_hsa041520.31868204
116Fatty acid biosynthesis_Homo sapiens_hsa000610.31636307
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31239005
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31022903
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30755405
120Mineral absorption_Homo sapiens_hsa049780.30489651
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30296049
122Colorectal cancer_Homo sapiens_hsa052100.30033405

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