AMDHD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.54022317
2neutrophil activation involved in immune response (GO:0002283)4.40966486
3superoxide anion generation (GO:0042554)4.35359616
4negative regulation of erythrocyte differentiation (GO:0045647)4.25328448
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.13071420
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.13071420
7modulation by symbiont of host immune response (GO:0052553)4.13071420
8positive regulation by symbiont of host defense response (GO:0052509)4.13071420
9modulation by symbiont of host defense response (GO:0052031)4.13071420
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.13071420
11regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.68495953
12response to peptidoglycan (GO:0032494)3.65394461
13respiratory burst (GO:0045730)3.64455006
14DNA deamination (GO:0045006)3.62847324
15protein localization to endosome (GO:0036010)3.52354009
16barbed-end actin filament capping (GO:0051016)3.47177684
17NIK/NF-kappaB signaling (GO:0038061)3.42781963
18proteasome assembly (GO:0043248)3.41736183
19negative regulation of cell killing (GO:0031342)3.35276470
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.35276470
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.23985552
22positive regulation of Cdc42 GTPase activity (GO:0043089)3.23586169
23neutrophil activation (GO:0042119)3.22985669
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21016354
25modulation by symbiont of host cellular process (GO:0044068)3.17531930
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.14166144
27regulation of leukocyte degranulation (GO:0043300)3.11890209
28lipoxygenase pathway (GO:0019372)3.10371183
29detection of other organism (GO:0098543)3.09369274
30* amino sugar catabolic process (GO:0046348)3.04767742
31modulation by virus of host process (GO:0019054)3.04717871
32detection of bacterium (GO:0016045)3.02954656
33epithelial cell differentiation involved in prostate gland development (GO:0060742)3.02910200
34negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.02770949
35pinocytosis (GO:0006907)3.01641485
36granulocyte activation (GO:0036230)3.01572286
37ribosomal small subunit biogenesis (GO:0042274)3.00817645
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.00786178
39positive regulation of gamma-delta T cell activation (GO:0046645)2.97962201
40neutrophil mediated immunity (GO:0002446)2.97826275
41antigen processing and presentation of endogenous antigen (GO:0019883)2.97547865
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.97166551
43superoxide metabolic process (GO:0006801)2.95834866
44low-density lipoprotein particle clearance (GO:0034383)2.95781032
45immunoglobulin mediated immune response (GO:0016064)2.94971903
46oligosaccharide catabolic process (GO:0009313)2.90357014
47glycosphingolipid catabolic process (GO:0046479)2.89719141
48regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89173362
49cellular response to thyroid hormone stimulus (GO:0097067)2.85632281
50regulation of extracellular matrix disassembly (GO:0010715)2.83817526
51positive regulation of antigen processing and presentation (GO:0002579)2.83266771
52detection of external biotic stimulus (GO:0098581)2.83061172
53macrophage activation involved in immune response (GO:0002281)2.81630405
54regulation of early endosome to late endosome transport (GO:2000641)2.80257511
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80033750
56response to host immune response (GO:0052572)2.80033750
57ribosomal small subunit assembly (GO:0000028)2.78632719
58pentose metabolic process (GO:0019321)2.77653685
59response to laminar fluid shear stress (GO:0034616)2.77382789
60telomere maintenance via semi-conservative replication (GO:0032201)2.76629531
61stress fiber assembly (GO:0043149)2.74374485
62positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73682959
63regulation of cholesterol storage (GO:0010885)2.72860484
64apoptotic process involved in morphogenesis (GO:0060561)2.72389070
65regulation of interferon-beta biosynthetic process (GO:0045357)2.71877638
66adenosine receptor signaling pathway (GO:0001973)2.71380132
67response to thyroid hormone (GO:0097066)2.71287727
68DNA strand elongation involved in DNA replication (GO:0006271)2.69428965
69ribosomal large subunit biogenesis (GO:0042273)2.67585503
70regulation of T-helper 2 cell differentiation (GO:0045628)2.66422582
71cytochrome complex assembly (GO:0017004)2.63814596
72myeloid dendritic cell differentiation (GO:0043011)2.62971150
73ceramide catabolic process (GO:0046514)2.62327925
74positive regulation of cholesterol efflux (GO:0010875)2.61735305
75regulation of superoxide anion generation (GO:0032928)2.60469061
76regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59451355
77germinal center formation (GO:0002467)2.59262425
78purine deoxyribonucleotide catabolic process (GO:0009155)2.58987571
79semaphorin-plexin signaling pathway (GO:0071526)2.58935911
80glycolipid catabolic process (GO:0019377)2.57781967
81peptide catabolic process (GO:0043171)2.57778489
82sphingolipid catabolic process (GO:0030149)2.57683972
83reactive oxygen species biosynthetic process (GO:1903409)2.57534533
84positive regulation of cellular amide metabolic process (GO:0034250)2.57331101
85leukotriene metabolic process (GO:0006691)2.57328158
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.56556167
87telomere maintenance via recombination (GO:0000722)2.56065524
88DNA strand elongation (GO:0022616)2.54385364
89response to folic acid (GO:0051593)2.54243022
90regulation of antigen processing and presentation (GO:0002577)2.54031229
91regulation of ARF GTPase activity (GO:0032312)2.52736153
92positive thymic T cell selection (GO:0045059)2.52341496
93negative regulation of interleukin-12 production (GO:0032695)2.51222638
94membrane lipid catabolic process (GO:0046466)2.50769850
95negative regulation of growth of symbiont in host (GO:0044130)2.48883338
96negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.48883338
97modulation of growth of symbiont involved in interaction with host (GO:0044144)2.48883338
98regulation of growth of symbiont in host (GO:0044126)2.48883338
99myeloid cell activation involved in immune response (GO:0002275)2.48099147
100mature B cell differentiation involved in immune response (GO:0002313)2.48019277
101microglial cell activation (GO:0001774)2.47661166
102apoptotic cell clearance (GO:0043277)2.47370331
103regulation of mast cell degranulation (GO:0043304)2.47350531
104detection of biotic stimulus (GO:0009595)2.45877339
105cellular response to interferon-beta (GO:0035458)2.45876005
106regulation of interleukin-8 biosynthetic process (GO:0045414)2.45688380
107pentose-phosphate shunt (GO:0006098)2.45587375
108positive regulation of receptor recycling (GO:0001921)2.43947782
109regulation of regulated secretory pathway (GO:1903305)2.42354782
110thymic T cell selection (GO:0045061)2.42126138
111hyaluronan catabolic process (GO:0030214)2.41800091
112respiratory chain complex IV assembly (GO:0008535)2.40352328
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.39959112
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.38727534
115response to interferon-beta (GO:0035456)2.38174801
116activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.38107034
117regulation of gamma-delta T cell activation (GO:0046643)2.35804864
118response to host (GO:0075136)2.35725239
119response to host defenses (GO:0052200)2.35725239
120response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.35725239
121Golgi transport vesicle coating (GO:0048200)2.34961510
122COPI coating of Golgi vesicle (GO:0048205)2.34961510
123negative regulation of innate immune response (GO:0045824)2.34870686
124positive regulation of leukocyte degranulation (GO:0043302)2.34453248
125mature B cell differentiation (GO:0002335)2.34443765
126negative regulation of granulocyte differentiation (GO:0030853)2.34166114
127negative regulation of cell size (GO:0045792)2.33695257
128antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.33656801
129regulation of defense response to virus by virus (GO:0050690)2.32989287
130negative regulation of toll-like receptor signaling pathway (GO:0034122)2.32920641
131regulation of cholesterol homeostasis (GO:2000188)2.31950890
132maturation of SSU-rRNA (GO:0030490)2.31861679
133multicellular organism reproduction (GO:0032504)2.31710116
134positive regulation of lipoprotein lipase activity (GO:0051006)2.31610114
135positive regulation of triglyceride lipase activity (GO:0061365)2.31610114
136regulation of mammary gland epithelial cell proliferation (GO:0033599)2.31506801
137regulation of mast cell activation (GO:0033003)2.31377456
138organic cation transport (GO:0015695)2.31074377
139response to fungus (GO:0009620)2.31062278
140cellular response to virus (GO:0098586)2.29935015
141defense response to protozoan (GO:0042832)2.29583028
142embryonic process involved in female pregnancy (GO:0060136)2.29233948
143response to type I interferon (GO:0034340)2.29130237
144negative regulation of cytokine production involved in immune response (GO:0002719)2.29124281
145viral transcription (GO:0019083)2.29061572
146negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.29034247
147regulation of B cell receptor signaling pathway (GO:0050855)2.28593145
148response to muramyl dipeptide (GO:0032495)2.28508946
149regulation of mitochondrial translation (GO:0070129)2.27854339
150negative regulation of nitric oxide biosynthetic process (GO:0045019)2.27515326
151type I interferon signaling pathway (GO:0060337)2.27389365
152cellular response to type I interferon (GO:0071357)2.27389365
153lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27058830
154basement membrane organization (GO:0071711)2.26879781
155mast cell activation (GO:0045576)2.26877401
156negative regulation of tumor necrosis factor production (GO:0032720)2.26506439
157aldehyde catabolic process (GO:0046185)2.24107736
158DNA integration (GO:0015074)2.22938367
159histamine transport (GO:0051608)2.22744171
160hydrogen peroxide biosynthetic process (GO:0050665)2.22674314
161GPI anchor biosynthetic process (GO:0006506)2.21450419
162regulation of mast cell activation involved in immune response (GO:0033006)2.20812793
163interferon-gamma secretion (GO:0072643)2.19880545
164leukocyte mediated cytotoxicity (GO:0001909)2.19112802
165glycoside metabolic process (GO:0016137)2.18357976
166deoxyribonucleotide catabolic process (GO:0009264)2.17947158
167lipopolysaccharide metabolic process (GO:0008653)2.17133389
168translational termination (GO:0006415)2.15527259
169DNA replication initiation (GO:0006270)2.15376938
170DNA strand renaturation (GO:0000733)2.14850401
171sphingosine metabolic process (GO:0006670)2.14543881
172detection of molecule of bacterial origin (GO:0032490)2.14418443
173diol metabolic process (GO:0034311)2.14310354
174positive regulation of interferon-alpha production (GO:0032727)2.13125638
175response to protozoan (GO:0001562)2.12638467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.59351311
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.33428087
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.20080524
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.86796451
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.29985975
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.15160119
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.11591105
8LXR_22292898_ChIP-Seq_THP-1_Human2.92599746
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.68099203
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.61890534
11MYC_22102868_ChIP-Seq_BL_Human2.60443000
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49944536
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.48151012
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.43231586
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.36800582
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.36749669
17* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34790530
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.33671266
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33016806
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23344547
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20934010
22FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.19578580
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17028132
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.12354250
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11594879
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10598231
27RACK7_27058665_Chip-Seq_MCF-7_Human2.09208913
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08554578
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.04819178
30TCF7_22412390_ChIP-Seq_EML_Mouse2.03607526
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01105588
32KDM2B_26808549_Chip-Seq_DND41_Human2.00375266
33* SPI1_23547873_ChIP-Seq_NB4_Human1.98887681
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.96214054
35* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96072811
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.95433172
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92092998
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.85233682
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.84970373
40* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83100900
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82895075
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79667671
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74922487
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74689900
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71402246
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.70987724
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.69676085
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68273372
49MAF_26560356_Chip-Seq_TH1_Human1.67525693
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66757417
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64395276
52P68_20966046_ChIP-Seq_HELA_Human1.64290414
53* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57863649
54MAF_26560356_Chip-Seq_TH2_Human1.57331495
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55920753
56KDM2B_26808549_Chip-Seq_K562_Human1.55599517
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.55435179
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55157954
59EGR1_23403033_ChIP-Seq_LIVER_Mouse1.55129927
60* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54697753
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.54449224
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.54189821
63* SRF_21415370_ChIP-Seq_HL-1_Mouse1.54021336
64VDR_21846776_ChIP-Seq_THP-1_Human1.52736927
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52254313
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.50713442
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50610221
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50170682
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.49894317
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48702056
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48538944
72ZNF263_19887448_ChIP-Seq_K562_Human1.47967044
73UTX_26944678_Chip-Seq_JUKART_Human1.47519294
74* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47103337
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.46301696
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46112162
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.46099253
78BCOR_27268052_Chip-Seq_Bcells_Human1.44765295
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44680759
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44454450
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42442398
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.40959866
83SMC4_20622854_ChIP-Seq_HELA_Human1.40565184
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39820081
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39678477
86* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39056950
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38894257
88BCL6_27268052_Chip-Seq_Bcells_Human1.38808884
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38603191
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37170149
91EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36677610
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35936063
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33209483
94* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32845633
95NCOR1_26117541_ChIP-Seq_K562_Human1.32317065
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31286367
97* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30175621
98MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29507939
99KDM2B_26808549_Chip-Seq_JURKAT_Human1.29391095
100SPI1_23127762_ChIP-Seq_K562_Human1.27978213
101* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27170413
102GATA1_19941827_ChIP-Seq_MEL_Mouse1.26912383
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26811364
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26465441
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26141472
106* VDR_23849224_ChIP-Seq_CD4+_Human1.25985229
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25969545
108CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25046883
109CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23843937
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23558528
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.23188019
112ERG_21242973_ChIP-ChIP_JURKAT_Human1.23161138
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22266667
114* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22203832
115SCL_19346495_ChIP-Seq_HPC-7_Human1.21516958
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21292056
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20550107
118VDR_24763502_ChIP-Seq_THP-1_Human1.20545389
119FOXP3_21729870_ChIP-Seq_TREG_Human1.20272969
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19947844
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.19278875
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.18697725
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16835609
124DCP1A_22483619_ChIP-Seq_HELA_Human1.15439607
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15336954
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14580472
127TP53_22127205_ChIP-Seq_IMR90_Human1.13915864
128CREB1_26743006_Chip-Seq_LNCaP_Human1.13432402
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13103579
130CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12883673
131* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12763249
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12561464
133RXR_22158963_ChIP-Seq_LIVER_Mouse1.12451835
134CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11992460
135* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11599929
136ATF3_27146783_Chip-Seq_COLON_Human1.11422314
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11362107
138HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11068829
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10544576
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10152169
141DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09991218
142SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09310094
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06386402
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06386402
145KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06386402
146* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06265858
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05580273
148STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04424487
149RUNX1_27514584_Chip-Seq_MCF-7_Human1.04174478
150SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03134043
151CTCF_26484167_Chip-Seq_Bcells_Mouse1.01510378
152SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01383207
153TTF2_22483619_ChIP-Seq_HELA_Human1.01379131
154PU_27001747_Chip-Seq_BMDM_Mouse1.00425863
155* TFEB_21752829_ChIP-Seq_HELA_Human0.99742089
156* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95950603
157YY1_22570637_ChIP-Seq_MALME-3M_Human0.95173445
158* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95126182
159GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94377134
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93351741
161STAT1_20625510_ChIP-Seq_HELA_Human0.93241017
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91707907
163CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91697662
164TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90939729
165FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90712526
166XRN2_22483619_ChIP-Seq_HELA_Human0.89370105
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89301363
168SPI1_20517297_ChIP-Seq_HL60_Human0.85578422
169CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83886802
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83791297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.72699501
2MP0009840_abnormal_foam_cell2.99418964
3MP0003705_abnormal_hypodermis_morpholog2.92196647
4MP0003436_decreased_susceptibility_to2.90652362
5MP0001835_abnormal_antigen_presentation2.89261628
6MP0003172_abnormal_lysosome_physiology2.89114566
7MP0005174_abnormal_tail_pigmentation2.68167659
8MP0002419_abnormal_innate_immunity2.58441305
9MP0009785_altered_susceptibility_to2.39623474
10MP0002148_abnormal_hypersensitivity_rea2.36581439
11MP0008260_abnormal_autophagy2.34181500
12MP0000015_abnormal_ear_pigmentation2.20232005
13MP0005025_abnormal_response_to2.19141102
14MP0005451_abnormal_body_composition2.14685622
15MP0003724_increased_susceptibility_to2.12574200
16MP0005000_abnormal_immune_tolerance2.12280629
17MP0006082_CNS_inflammation2.08616480
18MP0003136_yellow_coat_color2.03763534
19MP0002254_reproductive_system_inflammat2.02680733
20MP0001849_ear_inflammation1.99826736
21MP0003693_abnormal_embryo_hatching1.93345606
22MP0009333_abnormal_splenocyte_physiolog1.89586291
23MP0002452_abnormal_antigen_presenting1.87155917
24MP0002396_abnormal_hematopoietic_system1.86694376
25MP0003186_abnormal_redox_activity1.84929933
26MP0003300_gastrointestinal_ulcer1.84451825
27MP0004947_skin_inflammation1.84235020
28MP0004381_abnormal_hair_follicle1.83780089
29MP0003111_abnormal_nucleus_morphology1.79988156
30MP0003453_abnormal_keratinocyte_physiol1.78548571
31MP0004510_myositis1.77695065
32MP0002723_abnormal_immune_serum1.77317699
33MP0008058_abnormal_DNA_repair1.74784020
34MP0004019_abnormal_vitamin_homeostasis1.74606960
35MP0009764_decreased_sensitivity_to1.73528403
36MP0005076_abnormal_cell_differentiation1.73273144
37MP0000604_amyloidosis1.72963240
38MP0000490_abnormal_crypts_of1.71546052
39MP0002102_abnormal_ear_morphology1.71357606
40MP0005464_abnormal_platelet_physiology1.67461313
41MP0001800_abnormal_humoral_immune1.66211040
42MP0002277_abnormal_respiratory_mucosa1.65263378
43MP0002877_abnormal_melanocyte_morpholog1.60896087
44MP0001819_abnormal_immune_cell1.59698175
45MP0002420_abnormal_adaptive_immunity1.58002583
46MP0000858_altered_metastatic_potential1.57704421
47MP0005387_immune_system_phenotype1.57382762
48MP0001790_abnormal_immune_system1.57382762
49MP0005410_abnormal_fertilization1.57189634
50MP0002405_respiratory_system_inflammati1.52621382
51MP0008469_abnormal_protein_level1.49520201
52MP0004858_abnormal_nervous_system1.47967640
53MP0000371_diluted_coat_color1.44274515
54MP0003329_amyloid_beta_deposits1.39951759
55MP0010155_abnormal_intestine_physiology1.38219525
56MP0002132_abnormal_respiratory_system1.37694301
57MP0005360_urolithiasis1.36649701
58MP0001533_abnormal_skeleton_physiology1.36272826
59MP0004185_abnormal_adipocyte_glucose1.36089258
60MP0005075_abnormal_melanosome_morpholog1.35604279
61MP0003191_abnormal_cellular_cholesterol1.35570748
62MP0003303_peritoneal_inflammation1.34093169
63MP0001845_abnormal_inflammatory_respons1.32347796
64MP0003075_altered_response_to1.32174300
65MP0003566_abnormal_cell_adhesion1.30785019
66MP0005671_abnormal_response_to1.28928181
67MP0009278_abnormal_bone_marrow1.28582158
68MP0010094_abnormal_chromosome_stability1.27743473
69MP0003091_abnormal_cell_migration1.27277429
70MP0003183_abnormal_peptide_metabolism1.25167446
71MP0000689_abnormal_spleen_morphology1.24483744
72MP0000716_abnormal_immune_system1.24234866
73MP0003448_altered_tumor_morphology1.20372825
74MP0003279_aneurysm1.19329215
75MP0008438_abnormal_cutaneous_collagen1.18188708
76MP0000685_abnormal_immune_system1.17799068
77MP0008057_abnormal_DNA_replication1.14910547
78MP0002722_abnormal_immune_system1.13581425
79MP0000465_gastrointestinal_hemorrhage1.12993168
80MP0002429_abnormal_blood_cell1.12298536
81MP0009643_abnormal_urine_homeostasis1.11914269
82MP0005409_darkened_coat_color1.10250268
83MP0002398_abnormal_bone_marrow1.09121474
84MP0001853_heart_inflammation1.09076754
85MP0002139_abnormal_hepatobiliary_system1.08888734
86MP0003077_abnormal_cell_cycle1.07751412
87MP0003763_abnormal_thymus_physiology1.06437113
88MP0005666_abnormal_adipose_tissue1.03619063
89MP0002136_abnormal_kidney_physiology1.03447641
90MP0009379_abnormal_foot_pigmentation1.01163609
91MP0005408_hypopigmentation0.99535595
92MP0001348_abnormal_lacrimal_gland0.98718730
93MP0005310_abnormal_salivary_gland0.97211224
94MP0001663_abnormal_digestive_system0.95956129
95MP0001764_abnormal_homeostasis0.95733298
96MP0001545_abnormal_hematopoietic_system0.94959689
97MP0005397_hematopoietic_system_phenotyp0.94959689
98MP0000343_altered_response_to0.93129886
99MP0005332_abnormal_amino_acid0.92867902
100MP0005636_abnormal_mineral_homeostasis0.92384636
101MP0001958_emphysema0.91833676
102MP0001873_stomach_inflammation0.91362454
103MP0002095_abnormal_skin_pigmentation0.90450324
104MP0003828_pulmonary_edema0.88208098
105MP0003718_maternal_effect0.87717803
106MP0005381_digestive/alimentary_phenotyp0.87603486
107MP0002089_abnormal_postnatal_growth/wei0.87012328
108MP0004782_abnormal_surfactant_physiolog0.86513139
109MP0009763_increased_sensitivity_to0.86175076
110MP0000678_abnormal_parathyroid_gland0.86059129
111MP0005375_adipose_tissue_phenotype0.85285404
112MP0008932_abnormal_embryonic_tissue0.85006476
113MP0005023_abnormal_wound_healing0.84080699
114MP0000767_abnormal_smooth_muscle0.83521871
115MP0003950_abnormal_plasma_membrane0.83115290
116MP0002998_abnormal_bone_remodeling0.82468139
117MP0002796_impaired_skin_barrier0.82461327
118MP0003806_abnormal_nucleotide_metabolis0.82411558
119MP0010234_abnormal_vibrissa_follicle0.79890960
120MP0005390_skeleton_phenotype0.79479309
121MP0005257_abnormal_intraocular_pressure0.78998109
122MP0003195_calcinosis0.78944990
123MP0000372_irregular_coat_pigmentation0.78827115
124MP0003690_abnormal_glial_cell0.78022885
125MP0002933_joint_inflammation0.77833178
126MP0003786_premature_aging0.75455329
127MP0005171_absent_coat_pigmentation0.75246467
128MP0005670_abnormal_white_adipose0.74818168
129MP0005166_decreased_susceptibility_to0.74261532
130MP0003795_abnormal_bone_structure0.74139522
131MP0005365_abnormal_bile_salt0.73571280
132MP0004742_abnormal_vestibular_system0.73066384
133MP0004957_abnormal_blastocyst_morpholog0.72711587
134MP0005083_abnormal_biliary_tract0.72540063
135MP0003634_abnormal_glial_cell0.71299831
136MP0002019_abnormal_tumor_incidence0.70718720
137MP0006292_abnormal_olfactory_placode0.70539347
138MP0003656_abnormal_erythrocyte_physiolo0.70401908
139MP0000609_abnormal_liver_physiology0.70131242
140MP0000920_abnormal_myelination0.68769331
141MP0000747_muscle_weakness0.67834547

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.81122493
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.63103848
3Reticulocytopenia (HP:0001896)4.45076791
4Vacuolated lymphocytes (HP:0001922)4.25036016
5Duplicated collecting system (HP:0000081)4.19054868
6Chromsome breakage (HP:0040012)4.14931177
7Abnormality of the renal collecting system (HP:0004742)4.04977044
8Eczematoid dermatitis (HP:0000976)4.00517914
9Recurrent bacterial skin infections (HP:0005406)3.91810653
10Abnormality of macrophages (HP:0004311)3.72348972
11Recurrent gram-negative bacterial infections (HP:0005420)3.36064666
12Vertebral compression fractures (HP:0002953)3.21851604
13Nuclear cataract (HP:0100018)3.20084916
14Petechiae (HP:0000967)3.16087627
15Abnormality of glycolipid metabolism (HP:0010969)3.11263667
16Abnormality of liposaccharide metabolism (HP:0010968)3.11263667
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.11263667
18Abnormality of pyrimidine metabolism (HP:0004353)3.00798454
19Chronic obstructive pulmonary disease (HP:0006510)2.93673441
20Obstructive lung disease (HP:0006536)2.93673441
21Increased cerebral lipofuscin (HP:0011813)2.92777216
22Upper limb muscle weakness (HP:0003484)2.90025420
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.89834179
24Pustule (HP:0200039)2.83008752
25Prolonged neonatal jaundice (HP:0006579)2.80759411
26Elevated erythrocyte sedimentation rate (HP:0003565)2.80291540
27Axonal loss (HP:0003447)2.78340596
28Pallor (HP:0000980)2.76848508
29Hepatosplenomegaly (HP:0001433)2.71191599
30Gingivitis (HP:0000230)2.64034564
31Cerebral aneurysm (HP:0004944)2.62237981
32Recurrent skin infections (HP:0001581)2.62140787
33Abnormality of DNA repair (HP:0003254)2.60210249
34Dysostosis multiplex (HP:0000943)2.55676692
35Glomerulonephritis (HP:0000099)2.53625830
36Abnormality of cells of the erythroid lineage (HP:0012130)2.53074656
37Systemic lupus erythematosus (HP:0002725)2.52038323
38J-shaped sella turcica (HP:0002680)2.51868620
39Neurofibrillary tangles (HP:0002185)2.49386464
40Thin bony cortex (HP:0002753)2.48194161
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44664546
42Abnormal number of erythroid precursors (HP:0012131)2.44582725
43Myocardial infarction (HP:0001658)2.43582640
44Hemorrhage of the eye (HP:0011885)2.42529474
45Cervical subluxation (HP:0003308)2.40673981
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38539488
47Myositis (HP:0100614)2.37651931
48Basal ganglia calcification (HP:0002135)2.37442443
49Neuronal loss in central nervous system (HP:0002529)2.35119096
50Upper motor neuron abnormality (HP:0002127)2.34488843
51Pancytopenia (HP:0001876)2.31859808
52Achilles tendon contracture (HP:0001771)2.27753536
53Cellulitis (HP:0100658)2.27105807
54Bone marrow hypocellularity (HP:0005528)2.26896552
55Recurrent fungal infections (HP:0002841)2.26889977
56Mediastinal lymphadenopathy (HP:0100721)2.24662632
57Colitis (HP:0002583)2.24526905
58Nausea (HP:0002018)2.23347140
59Duplication of thumb phalanx (HP:0009942)2.21925658
60Cerebral inclusion bodies (HP:0100314)2.21090343
61Increased serum ferritin (HP:0003281)2.20030430
62Parakeratosis (HP:0001036)2.19473733
63Increased connective tissue (HP:0009025)2.17927442
64Type I transferrin isoform profile (HP:0003642)2.17327363
65Stomatitis (HP:0010280)2.17156520
66Asymmetric septal hypertrophy (HP:0001670)2.16055070
67Distal lower limb muscle weakness (HP:0009053)2.13309257
68IgM deficiency (HP:0002850)2.13080186
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12527391
70Disinhibition (HP:0000734)2.09886968
71Macrocytic anemia (HP:0001972)2.08251483
72Joint hemorrhage (HP:0005261)2.08130052
73Abnormality of the Achilles tendon (HP:0005109)2.08031294
74Protrusio acetabuli (HP:0003179)2.06686622
75Abnormality of reticulocytes (HP:0004312)2.06012431
76Thoracic kyphosis (HP:0002942)2.04163886
77Recurrent pneumonia (HP:0006532)2.03504200
78Abnormality of complement system (HP:0005339)2.03279924
79Prostate neoplasm (HP:0100787)2.02921873
803-Methylglutaconic aciduria (HP:0003535)2.02698014
81Cheilitis (HP:0100825)2.02635613
82Abnormality of the thoracic spine (HP:0100711)2.02356457
83Reduced antithrombin III activity (HP:0001976)2.01724430
84Hypokinesia (HP:0002375)2.01666096
85Joint stiffness (HP:0001387)2.00924209
86Broad face (HP:0000283)2.00825048
87Abnormality of magnesium homeostasis (HP:0004921)2.00746847
88Hyperacusis (HP:0010780)2.00736840
89Progressive neurologic deterioration (HP:0002344)2.00709753
90Abnormality of polysaccharide metabolism (HP:0011012)2.00433941
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00433941
92Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00433941
93Ureteral duplication (HP:0000073)1.97938149
94Abnormality of the preputium (HP:0100587)1.97898646
95Premature loss of primary teeth (HP:0006323)1.96028754
96Purpura (HP:0000979)1.95845533
97Distal lower limb amyotrophy (HP:0008944)1.95755068
98Orchitis (HP:0100796)1.94483157
99Urinary glycosaminoglycan excretion (HP:0003541)1.94184054
100Mucopolysacchariduria (HP:0008155)1.94184054
101Upper limb amyotrophy (HP:0009129)1.94090897
102Distal upper limb amyotrophy (HP:0007149)1.94090897
103Personality changes (HP:0000751)1.93741312
104Loss of speech (HP:0002371)1.93048028
105Biconcave vertebral bodies (HP:0004586)1.92830806
106Chronic otitis media (HP:0000389)1.92616712
107Spontaneous hematomas (HP:0007420)1.92526682
108Bone pain (HP:0002653)1.91897198
109Meckel diverticulum (HP:0002245)1.91157152
110Emphysema (HP:0002097)1.91002503
111Hypertriglyceridemia (HP:0002155)1.90818450
112Abnormality of chromosome stability (HP:0003220)1.90191402
113Malnutrition (HP:0004395)1.89102834
114Abnormal protein glycosylation (HP:0012346)1.86337127
115Abnormal glycosylation (HP:0012345)1.86337127
116Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86337127
117Abnormal protein N-linked glycosylation (HP:0012347)1.86337127
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.86098290
119Supranuclear gaze palsy (HP:0000605)1.85923925
120Gastrointestinal inflammation (HP:0004386)1.85371142
121Interstitial pulmonary disease (HP:0006530)1.84651395
122Abnormality of the nasal mucosa (HP:0000433)1.84515783
123Ulnar bowing (HP:0003031)1.84364526
124Abnormality of the ileum (HP:0001549)1.83889371
125Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83738347
126Deep venous thrombosis (HP:0002625)1.82266225
127Agnosia (HP:0010524)1.82031734
128Urticaria (HP:0001025)1.81583578
129Stridor (HP:0010307)1.80455607
130Xanthomatosis (HP:0000991)1.79987284
131Polygenic inheritance (HP:0010982)1.78014361
132Retrobulbar optic neuritis (HP:0100654)1.77892452
133Optic neuritis (HP:0100653)1.77892452
134Segmental peripheral demyelination/remyelination (HP:0003481)1.77695952
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77546676
136Increased IgE level (HP:0003212)1.77540616
137Hypertensive crisis (HP:0100735)1.77490084
138Clubbing of toes (HP:0100760)1.77386219
139Meningitis (HP:0001287)1.76389540
140Apathy (HP:0000741)1.75525667
141Slow saccadic eye movements (HP:0000514)1.74920518
142Leukocytosis (HP:0001974)1.74782369
143Pathologic fracture (HP:0002756)1.74705978
144Congenital ichthyosiform erythroderma (HP:0007431)1.74492995
145Chronic mucocutaneous candidiasis (HP:0002728)1.74327713
146Recurrent cutaneous fungal infections (HP:0011370)1.74327713
147Obstructive sleep apnea (HP:0002870)1.73313053
148Hypomagnesemia (HP:0002917)1.72781111
149Albinism (HP:0001022)1.72600779
150Gingival bleeding (HP:0000225)1.72102354
151Osteomyelitis (HP:0002754)1.71533593
152Abnormality of alkaline phosphatase activity (HP:0004379)1.70948540
153Absent/shortened dynein arms (HP:0200106)1.70860621
154Dynein arm defect of respiratory motile cilia (HP:0012255)1.70860621
155Amyloidosis (HP:0011034)1.70699235
156Complement deficiency (HP:0004431)1.70092576
157Diminished motivation (HP:0000745)1.69107370
158Inflammation of the large intestine (HP:0002037)1.68280657
159Gastrointestinal stroma tumor (HP:0100723)1.66096280
160Premature rupture of membranes (HP:0001788)1.65650368
161Dementia (HP:0000726)1.65062071
162Deformed sella turcica (HP:0002681)1.64787463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.12816658
2STK164.62076938
3TRIB34.20657620
4IRAK33.34842046
5PRPF4B2.92223791
6SIK12.91959075
7IRAK42.85262591
8TLK12.41102317
9SMG12.40201848
10KIT2.36143324
11PIM22.19127477
12CLK12.16951083
13PBK2.06543605
14NME22.01420348
15ICK2.00665244
16BUB12.00358378
17MAP3K141.99527748
18EPHB11.99397546
19EIF2AK21.89589386
20TAOK21.83730164
21MAP3K31.79157850
22MAP4K11.78759199
23RIPK11.77795151
24ERN11.77381281
25TBK11.73569383
26EPHA21.64069573
27FGFR41.63119867
28TTK1.60464267
29CDK191.56451197
30TYK21.53353095
31TAOK31.53091043
32TAOK11.49579476
33IKBKB1.48329823
34DDR21.43404255
35EEF2K1.41937032
36SIK21.39870953
37FES1.39091296
38PKN21.38004718
39RIPK41.37190851
40WEE11.36789976
41IRAK11.36774935
42MAP3K131.36482139
43MATK1.35916812
44ADRBK21.32105736
45ZAK1.29479012
46CSK1.27260552
47CDC42BPA1.25610962
48LYN1.24605478
49TTN1.24063853
50TNIK1.22371529
51TXK1.20501423
52PRKD21.19989358
53GRK11.17843720
54MAP3K11.14368675
55SIK31.13936225
56IKBKE1.09112736
57MARK21.09053470
58CDK121.08520481
59PDPK11.07623626
60BTK1.07064210
61TEC1.06186987
62CDK71.04895005
63ABL21.02783060
64PDGFRA1.02396519
65PTK61.01259655
66STK41.00777762
67PIM11.00189159
68MAP3K100.99819161
69CSF1R0.98796843
70RPS6KA20.98104017
71PAK40.93673037
72KDR0.91437587
73MAP2K30.90942623
74EIF2AK30.90326085
75MAP2K20.88633853
76RPS6KL10.85689988
77RPS6KC10.85689988
78ACVR1B0.85386878
79BMX0.84363578
80FLT30.84007900
81LCK0.83946834
82ZAP700.79345773
83VRK10.77560778
84STK100.76289687
85DYRK30.75827406
86STK390.74853915
87KSR20.74808346
88PASK0.74458056
89GRK60.74302272
90SYK0.72674985
91YES10.72433410
92MTOR0.71211899
93MST40.71211819
94PLK10.70792560
95MAPK110.69311263
96WNK40.69306200
97HCK0.69060009
98NEK20.68451065
99EPHA30.68283569
100ARAF0.67614956
101DYRK1B0.67393953
102FGR0.66368748
103SRPK10.65292029
104PDK10.64872033
105ATR0.64567090
106RPS6KA60.64101237
107MAPK120.64021675
108MAP3K60.63097878
109PIK3CG0.62386199
110CDK40.61730551
111PRKCD0.58815988
112TYRO30.58013438
113TESK10.57242668
114NLK0.56937644
115TGFBR20.56805678
116PRKG20.56760463
117PRKD30.54538750
118TRPM70.53685693
119AURKA0.52547380
120CHEK20.52364848
121CAMKK10.51307033
122MAP3K80.51245604
123BCKDK0.50644062
124CAMK1D0.50369709
125OXSR10.50355562
126HIPK20.50313351
127JAK10.50070397
128MARK30.49669711
129RPS6KA50.49149216
130PAK10.47228374
131NEK90.46993563
132PTK20.46952082
133MAPKAPK50.46623402
134AURKB0.46347224
135PLK40.46159466
136STK380.44036355
137CDK60.43783149
138CSNK2A10.43591040
139BRAF0.42583766
140TNK20.41358304
141MAPKAPK20.40228902
142GRK70.39966042
143MST1R0.39862050
144MAPK70.39043581
145JAK30.38151488
146MAP3K70.37949943
147MAP3K110.37086355
148TESK20.36818805
149ABL10.36706438
150IRAK20.36251379
151RPS6KA10.35079308
152JAK20.34499113
153CHUK0.33452970
154NME10.32740864
155MAP2K60.32654695

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.89458201
2Ribosome_Homo sapiens_hsa030102.59922872
3DNA replication_Homo sapiens_hsa030302.58811524
4Proteasome_Homo sapiens_hsa030502.38353384
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.31606814
6Homologous recombination_Homo sapiens_hsa034402.26207990
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03393529
8Staphylococcus aureus infection_Homo sapiens_hsa051501.96087548
9Lysosome_Homo sapiens_hsa041421.95373033
10Mismatch repair_Homo sapiens_hsa034301.93170617
11Folate biosynthesis_Homo sapiens_hsa007901.92517149
12Acute myeloid leukemia_Homo sapiens_hsa052211.84918883
13Fanconi anemia pathway_Homo sapiens_hsa034601.81199268
14B cell receptor signaling pathway_Homo sapiens_hsa046621.72160621
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68391786
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.66986602
17Pyrimidine metabolism_Homo sapiens_hsa002401.65122805
18Vitamin digestion and absorption_Homo sapiens_hsa049771.61083443
19Base excision repair_Homo sapiens_hsa034101.60932699
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58421763
21* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54306094
22One carbon pool by folate_Homo sapiens_hsa006701.51488723
23RNA polymerase_Homo sapiens_hsa030201.50145704
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47903482
25Glutathione metabolism_Homo sapiens_hsa004801.47814393
26Bladder cancer_Homo sapiens_hsa052191.46198355
27Notch signaling pathway_Homo sapiens_hsa043301.45680873
28Leishmaniasis_Homo sapiens_hsa051401.45583271
29Arachidonic acid metabolism_Homo sapiens_hsa005901.43629240
30Sphingolipid metabolism_Homo sapiens_hsa006001.42732294
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.41390492
32Toxoplasmosis_Homo sapiens_hsa051451.41042695
33Chronic myeloid leukemia_Homo sapiens_hsa052201.40314791
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37040291
35Non-homologous end-joining_Homo sapiens_hsa034501.35356800
36VEGF signaling pathway_Homo sapiens_hsa043701.35151088
37Malaria_Homo sapiens_hsa051441.35012228
38Nucleotide excision repair_Homo sapiens_hsa034201.32958492
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26060183
40TNF signaling pathway_Homo sapiens_hsa046681.25243656
41Steroid biosynthesis_Homo sapiens_hsa001001.23854176
42Renin-angiotensin system_Homo sapiens_hsa046141.23059691
43Oxidative phosphorylation_Homo sapiens_hsa001901.21523550
44Non-small cell lung cancer_Homo sapiens_hsa052231.21066779
45Legionellosis_Homo sapiens_hsa051341.20056349
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18169294
47Histidine metabolism_Homo sapiens_hsa003401.18090761
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17359909
49Pentose phosphate pathway_Homo sapiens_hsa000301.17048155
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16876068
51Prion diseases_Homo sapiens_hsa050201.16474892
52beta-Alanine metabolism_Homo sapiens_hsa004101.13867290
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12825277
54Hepatitis C_Homo sapiens_hsa051601.12652182
55Phagosome_Homo sapiens_hsa041451.11423390
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11403316
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.11375053
58Pertussis_Homo sapiens_hsa051331.09252695
59Autoimmune thyroid disease_Homo sapiens_hsa053201.08719658
60Arginine and proline metabolism_Homo sapiens_hsa003301.04722200
61Hepatitis B_Homo sapiens_hsa051611.02937234
62Pancreatic cancer_Homo sapiens_hsa052121.02776500
63Rheumatoid arthritis_Homo sapiens_hsa053231.00648390
64Neurotrophin signaling pathway_Homo sapiens_hsa047221.00610991
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00402767
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99564883
67Vitamin B6 metabolism_Homo sapiens_hsa007500.99303295
68Asthma_Homo sapiens_hsa053100.99123870
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.98707111
70Tuberculosis_Homo sapiens_hsa051520.97629612
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97539304
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.96365290
73Hematopoietic cell lineage_Homo sapiens_hsa046400.95834608
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94490016
75Mineral absorption_Homo sapiens_hsa049780.94054580
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.93950803
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.93850934
78Viral myocarditis_Homo sapiens_hsa054160.93720812
79Measles_Homo sapiens_hsa051620.92026153
80Endocytosis_Homo sapiens_hsa041440.91394330
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90039497
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89564538
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88850846
84Graft-versus-host disease_Homo sapiens_hsa053320.88516765
85mTOR signaling pathway_Homo sapiens_hsa041500.86396198
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85733862
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.85247165
88Ether lipid metabolism_Homo sapiens_hsa005650.84781447
89T cell receptor signaling pathway_Homo sapiens_hsa046600.84765654
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82855200
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82512637
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81447591
93Osteoclast differentiation_Homo sapiens_hsa043800.81132949
94African trypanosomiasis_Homo sapiens_hsa051430.80104961
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79599127
96Allograft rejection_Homo sapiens_hsa053300.79354555
97Linoleic acid metabolism_Homo sapiens_hsa005910.79312892
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78667033
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.78520479
100p53 signaling pathway_Homo sapiens_hsa041150.78118883
101Sulfur relay system_Homo sapiens_hsa041220.75156489
102Apoptosis_Homo sapiens_hsa042100.75059494
103Chemokine signaling pathway_Homo sapiens_hsa040620.74939344
104ABC transporters_Homo sapiens_hsa020100.74617982
105Purine metabolism_Homo sapiens_hsa002300.74017549
106Endometrial cancer_Homo sapiens_hsa052130.73236536
107Fructose and mannose metabolism_Homo sapiens_hsa000510.73155139
108Vibrio cholerae infection_Homo sapiens_hsa051100.72920282
109Collecting duct acid secretion_Homo sapiens_hsa049660.72900810
110Viral carcinogenesis_Homo sapiens_hsa052030.72585980
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72485275
112Peroxisome_Homo sapiens_hsa041460.72326536
113Renal cell carcinoma_Homo sapiens_hsa052110.71911990
114Prolactin signaling pathway_Homo sapiens_hsa049170.71166477
115Insulin signaling pathway_Homo sapiens_hsa049100.70259686
116Amoebiasis_Homo sapiens_hsa051460.69950987
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.69782404
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68510524
119Spliceosome_Homo sapiens_hsa030400.67860417
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67497078
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66831587
122Systemic lupus erythematosus_Homo sapiens_hsa053220.66143381
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66119245
124HTLV-I infection_Homo sapiens_hsa051660.65816279
125Insulin resistance_Homo sapiens_hsa049310.65675327
126Antigen processing and presentation_Homo sapiens_hsa046120.65011526
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64671744
128Herpes simplex infection_Homo sapiens_hsa051680.63398808
129Metabolic pathways_Homo sapiens_hsa011000.63131417
130GnRH signaling pathway_Homo sapiens_hsa049120.62945162
131Small cell lung cancer_Homo sapiens_hsa052220.62519228
132HIF-1 signaling pathway_Homo sapiens_hsa040660.62257599
133Parkinsons disease_Homo sapiens_hsa050120.61344931
134Huntingtons disease_Homo sapiens_hsa050160.61152460
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.58967878
136Retinol metabolism_Homo sapiens_hsa008300.58942649
137Primary immunodeficiency_Homo sapiens_hsa053400.58412634
138Tryptophan metabolism_Homo sapiens_hsa003800.58136524
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57799237
140Caffeine metabolism_Homo sapiens_hsa002320.57792575
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56789215
142Complement and coagulation cascades_Homo sapiens_hsa046100.55838375
143Type I diabetes mellitus_Homo sapiens_hsa049400.55295398
144Influenza A_Homo sapiens_hsa051640.54853277
145Glioma_Homo sapiens_hsa052140.54260316
146Prostate cancer_Homo sapiens_hsa052150.51938639
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51733150
148ErbB signaling pathway_Homo sapiens_hsa040120.50993900
149Galactose metabolism_Homo sapiens_hsa000520.50631306
150Proteoglycans in cancer_Homo sapiens_hsa052050.50336404
151Inositol phosphate metabolism_Homo sapiens_hsa005620.50233854
152Salmonella infection_Homo sapiens_hsa051320.49377224
153Shigellosis_Homo sapiens_hsa051310.49373612
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48972594
155Thyroid cancer_Homo sapiens_hsa052160.48307399
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.48183747
157Epstein-Barr virus infection_Homo sapiens_hsa051690.47905305
158Fatty acid elongation_Homo sapiens_hsa000620.46048258
159Basal transcription factors_Homo sapiens_hsa030220.44928314

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