ALPP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.83646135
2doxorubicin metabolic process (GO:0044598)6.83646135
3daunorubicin metabolic process (GO:0044597)6.83646135
4cornea development in camera-type eye (GO:0061303)6.22515942
5aminoglycoside antibiotic metabolic process (GO:0030647)6.01823310
6desmosome organization (GO:0002934)5.95450642
7pentose-phosphate shunt (GO:0006098)5.47648052
8estrogen metabolic process (GO:0008210)5.34805835
9branching involved in salivary gland morphogenesis (GO:0060445)5.33033673
10NADPH regeneration (GO:0006740)5.31024167
11female pregnancy (GO:0007565)5.09779077
12regulation of hippo signaling (GO:0035330)5.06152218
13regulation of gonadotropin secretion (GO:0032276)5.06050461
14androgen biosynthetic process (GO:0006702)4.80931774
15pentose metabolic process (GO:0019321)4.78834421
16protein autoprocessing (GO:0016540)4.75232785
17negative regulation of stress fiber assembly (GO:0051497)4.73056245
18response to follicle-stimulating hormone (GO:0032354)4.65971212
19glucose catabolic process (GO:0006007)4.58957482
20vitamin transmembrane transport (GO:0035461)4.51740076
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.49840315
22C21-steroid hormone biosynthetic process (GO:0006700)4.19293399
23hippo signaling (GO:0035329)4.16672706
24embryonic process involved in female pregnancy (GO:0060136)4.04901244
25keratinocyte development (GO:0003334)3.97053687
26regulation of ruffle assembly (GO:1900027)3.90167086
27hepatocyte apoptotic process (GO:0097284)3.85964248
28glucocorticoid biosynthetic process (GO:0006704)3.72600146
29cysteine metabolic process (GO:0006534)3.71450349
30response to growth hormone (GO:0060416)3.68472918
31membrane budding (GO:0006900)3.62012843
32hormone biosynthetic process (GO:0042446)3.54439894
33multi-multicellular organism process (GO:0044706)3.52831026
34androgen metabolic process (GO:0008209)3.51915736
35ribosome assembly (GO:0042255)3.50172232
36folic acid metabolic process (GO:0046655)3.48544185
37proteasome assembly (GO:0043248)3.42906607
38regulation of phospholipase A2 activity (GO:0032429)3.40149291
39asymmetric protein localization (GO:0008105)3.37936696
40sphingosine metabolic process (GO:0006670)3.36613296
41positive regulation of keratinocyte differentiation (GO:0045618)3.36326371
42nucleobase-containing small molecule interconversion (GO:0015949)3.31781047
43negative regulation of actin filament bundle assembly (GO:0032232)3.29490450
44membrane raft organization (GO:0031579)3.27642383
45collecting duct development (GO:0072044)3.25881761
46NADP metabolic process (GO:0006739)3.21872372
47positive regulation of odontogenesis (GO:0042482)3.20613416
48amyloid precursor protein metabolic process (GO:0042982)3.16408915
49basement membrane organization (GO:0071711)3.15607236
50regulation of G0 to G1 transition (GO:0070316)3.13348622
51response to food (GO:0032094)3.12870186
52eyelid development in camera-type eye (GO:0061029)3.09990689
53multi-organism reproductive process (GO:0044703)3.09220159
54sphingoid metabolic process (GO:0046519)3.09124229
55apical protein localization (GO:0045176)3.06975540
56C21-steroid hormone metabolic process (GO:0008207)3.06737806
57prostate gland growth (GO:0060736)3.06169744
58glycoside metabolic process (GO:0016137)3.05597957
59homocysteine metabolic process (GO:0050667)3.04200012
60diaphragm development (GO:0060539)3.03566315
61positive regulation of epidermal cell differentiation (GO:0045606)3.01902592
62notochord development (GO:0030903)2.97712147
63apoptotic process involved in morphogenesis (GO:0060561)2.87285428
64cyclooxygenase pathway (GO:0019371)2.86088738
65diol metabolic process (GO:0034311)2.82604527
66focal adhesion assembly (GO:0048041)2.80473480
67cell-substrate adherens junction assembly (GO:0007045)2.80473480
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.79443640
69negative regulation of kidney development (GO:0090185)2.77867340
70positive regulation of protein kinase C signaling (GO:0090037)2.77402169
71pyrimidine nucleoside salvage (GO:0043097)2.76804941
72pyrimidine-containing compound salvage (GO:0008655)2.76804941
73regulation of cholesterol biosynthetic process (GO:0045540)2.76700436
74norepinephrine metabolic process (GO:0042415)2.75012288
75COPI coating of Golgi vesicle (GO:0048205)2.70314226
76Golgi transport vesicle coating (GO:0048200)2.70314226
77polarized epithelial cell differentiation (GO:0030859)2.69197628
78regulation of cellular amino acid metabolic process (GO:0006521)2.68954308
79iron ion import (GO:0097286)2.68468143
80positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.67298579
81regulation of water loss via skin (GO:0033561)2.66724735
82epithelial cell-cell adhesion (GO:0090136)2.65154596
83prostanoid biosynthetic process (GO:0046457)2.64570265
84prostaglandin biosynthetic process (GO:0001516)2.64570265
85positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.64522990
86prostanoid metabolic process (GO:0006692)2.64012848
87prostaglandin metabolic process (GO:0006693)2.64012848
88regulation of translational termination (GO:0006449)2.61812695
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61402481
90face development (GO:0060324)2.59527196
91positive regulation of triglyceride biosynthetic process (GO:0010867)2.59263578
92tRNA methylation (GO:0030488)2.58680967
93anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56513080
94terpenoid biosynthetic process (GO:0016114)2.52701049
95quinone metabolic process (GO:1901661)2.51466837
96positive regulation of Cdc42 GTPase activity (GO:0043089)2.50448794
97activation of Rac GTPase activity (GO:0032863)2.50289532
98cell-cell junction maintenance (GO:0045217)2.49974596
99urea cycle (GO:0000050)2.49143049
100estrogen biosynthetic process (GO:0006703)11.3355116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF263_19887448_ChIP-Seq_K562_Human5.20718978
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.31721896
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.52775783
4ESR2_21235772_ChIP-Seq_MCF-7_Human2.89841998
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83962731
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.83068558
7PPAR_26484153_Chip-Seq_NCI-H1993_Human2.51656540
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49858037
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.40616280
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.23775672
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17594143
12ESR1_15608294_ChIP-ChIP_MCF-7_Human2.12941621
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.07288962
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.07288962
15E2F7_22180533_ChIP-Seq_HELA_Human2.07177261
16RACK7_27058665_Chip-Seq_MCF-7_Human2.05199112
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03792175
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.01673552
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00162048
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96444096
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.93294589
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89142245
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88904224
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.86711806
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86040138
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84615023
27AR_21909140_ChIP-Seq_LNCAP_Human1.82445847
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.80770180
29TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.76173959
30ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.75885369
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.75047042
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74723378
33GATA6_25053715_ChIP-Seq_YYC3_Human1.65212119
34EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.63319943
35SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62305262
36KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59820862
37ATF3_27146783_Chip-Seq_COLON_Human1.58264713
38GATA4_25053715_ChIP-Seq_YYC3_Human1.57628135
39AHR_22903824_ChIP-Seq_MCF-7_Human1.54618254
40DCP1A_22483619_ChIP-Seq_HELA_Human1.53536317
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.51484575
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50992913
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.50597651
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49909290
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47768733
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46594520
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41297161
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39259622
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.39080910
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.38161821
51ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37815365
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36308415
53KDM5A_27292631_Chip-Seq_BREAST_Human1.36239128
54SMC4_20622854_ChIP-Seq_HELA_Human1.34388352
55XRN2_22483619_ChIP-Seq_HELA_Human1.33758907
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33141251
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32309534
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.31784488
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30148866
60RUNX1_27514584_Chip-Seq_MCF-7_Human1.29583405
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.28347138
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27651651
63CHD1_26751641_Chip-Seq_LNCaP_Human1.23012634
64ELF5_23300383_ChIP-Seq_T47D_Human1.17277907
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17090506
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16668913
67TFEB_21752829_ChIP-Seq_HELA_Human1.16295402
68SOX2_20726797_ChIP-Seq_SW620_Human1.14481492
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.13773421
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12435586
71ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11707693
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11207920
73E2F1_20622854_ChIP-Seq_HELA_Human1.07935015
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06797748
75CLOCK_20551151_ChIP-Seq_293T_Human1.05279131
76GABP_19822575_ChIP-Seq_HepG2_Human1.05203002
77CDX2_20551321_ChIP-Seq_CACO-2_Human1.05050094
78EOMES_21245162_ChIP-Seq_HESCs_Human1.03742945
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01973434
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01692918
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00962095
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00131475
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97758555
84MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97567925
85TP63_22573176_ChIP-Seq_HFKS_Human0.97534634
86UBF1/2_26484160_Chip-Seq_HMECs_Human0.96385617
87P68_20966046_ChIP-Seq_HELA_Human0.96037454
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95274587
89KLF5_25053715_ChIP-Seq_YYC3_Human0.94647218
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.93001780
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.92910999
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92850374
93TET1_21451524_ChIP-Seq_MESCs_Mouse0.92771662
94P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91191819
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91020322
96SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90638956
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90162899
98LXR_22292898_ChIP-Seq_THP-1_Human0.90158562
99TTF2_22483619_ChIP-Seq_HELA_Human0.88881236
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88086747

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation6.68631814
2MP0010234_abnormal_vibrissa_follicle4.07696745
3MP0004233_abnormal_muscle_weight3.62061430
4MP0004264_abnormal_extraembryonic_tissu3.56051572
5MP0003806_abnormal_nucleotide_metabolis3.45095613
6MP0005623_abnormal_meninges_morphology3.09962953
7MP0009780_abnormal_chondrocyte_physiolo2.93332354
8MP0002163_abnormal_gland_morphology2.71423266
9MP0005076_abnormal_cell_differentiation2.23505516
10MP0003693_abnormal_embryo_hatching2.10388011
11MP0000013_abnormal_adipose_tissue2.01541281
12MP0004957_abnormal_blastocyst_morpholog1.98152449
13MP0001348_abnormal_lacrimal_gland1.97743233
14MP0000003_abnormal_adipose_tissue1.96756130
15MP0010678_abnormal_skin_adnexa1.93469538
16MP0000383_abnormal_hair_follicle1.79760189
17MP0004782_abnormal_surfactant_physiolog1.77810336
18MP0000647_abnormal_sebaceous_gland1.73730218
19MP0004019_abnormal_vitamin_homeostasis1.73063520
20MP0003186_abnormal_redox_activity1.68366891
21MP0005501_abnormal_skin_physiology1.65457168
22MP0005379_endocrine/exocrine_gland_phen1.64961583
23MP0003077_abnormal_cell_cycle1.62319166
24MP0006138_congestive_heart_failure1.58601388
25MP0002796_impaired_skin_barrier1.57707819
26MP0003718_maternal_effect1.57177304
27MP0003950_abnormal_plasma_membrane1.54162982
28MP0001730_embryonic_growth_arrest1.53738999
29MP0002098_abnormal_vibrissa_morphology1.49943309
30MP0000462_abnormal_digestive_system1.45217671
31MP0003453_abnormal_keratinocyte_physiol1.39999716
32MP0002086_abnormal_extraembryonic_tissu1.39873973
33MP0002909_abnormal_adrenal_gland1.39351620
34MP0008875_abnormal_xenobiotic_pharmacok1.35966846
35MP0005023_abnormal_wound_healing1.35140205
36MP0010352_gastrointestinal_tract_polyps1.33080083
37MP0005083_abnormal_biliary_tract1.32189978
38MP0005377_hearing/vestibular/ear_phenot1.31782969
39MP0003878_abnormal_ear_physiology1.31782969
40MP0003111_abnormal_nucleus_morphology1.28509483
41MP0005319_abnormal_enzyme/_coenzyme1.25488385
42MP0001216_abnormal_epidermal_layer1.23735119
43MP0005058_abnormal_lysosome_morphology1.23427721
44MP0005197_abnormal_uvea_morphology1.21950316
45MP0005647_abnormal_sex_gland1.19950172
46MP0000358_abnormal_cell_content/1.19041449
47MP0003941_abnormal_skin_development1.18447162
48MP0002080_prenatal_lethality1.17403228
49MP0005330_cardiomyopathy1.14860355
50MP0004858_abnormal_nervous_system1.13897630
51MP0003959_abnormal_lean_body1.11778303
52MP0002269_muscular_atrophy1.11617790
53MP0001697_abnormal_embryo_size1.10208331
54MP0002697_abnormal_eye_size1.09189948
55MP0003786_premature_aging1.09153387
56MP0004185_abnormal_adipocyte_glucose1.06669090
57MP0006035_abnormal_mitochondrial_morpho1.04420126
58MP0010030_abnormal_orbit_morphology1.04280511
59MP0003566_abnormal_cell_adhesion1.02648766
60MP0000579_abnormal_nail_morphology1.01353698
61MP0001661_extended_life_span0.99347648
62MP0005380_embryogenesis_phenotype0.98615195
63MP0001672_abnormal_embryogenesis/_devel0.98615195
64MP0004133_heterotaxia0.98453034
65MP0000377_abnormal_hair_follicle0.98190854
66MP0002084_abnormal_developmental_patter0.97247629
67MP0010094_abnormal_chromosome_stability0.96828564
68MP0002877_abnormal_melanocyte_morpholog0.96653998
69MP0000467_abnormal_esophagus_morphology0.96335652
70MP0000350_abnormal_cell_proliferation0.94961737
71MP0002876_abnormal_thyroid_physiology0.93439023
72MP0010771_integument_phenotype0.92950795
73MP0000627_abnormal_mammary_gland0.92492176
74MP0003936_abnormal_reproductive_system0.92001646
75MP0000639_abnormal_adrenal_gland0.89982976
76MP0003984_embryonic_growth_retardation0.89790792
77MP0008932_abnormal_embryonic_tissue0.88528122
78MP0000762_abnormal_tongue_morphology0.87915965
79MP0000613_abnormal_salivary_gland0.87733932
80MP0005451_abnormal_body_composition0.86738805
81MP0002088_abnormal_embryonic_growth/wei0.85905580
82MP0009115_abnormal_fat_cell0.81925790
83MP0003191_abnormal_cellular_cholesterol0.79198363
84MP0000537_abnormal_urethra_morphology0.76900675
85MP0002653_abnormal_ependyma_morphology0.76067895
86MP0010307_abnormal_tumor_latency0.75771818
87MP0006276_abnormal_autonomic_nervous0.75704753
88MP0005375_adipose_tissue_phenotype0.75346633
89MP0003115_abnormal_respiratory_system0.74358551
90MP0005584_abnormal_enzyme/coenzyme_acti0.73454565
91MP0002085_abnormal_embryonic_tissue0.73123076
92MP0001340_abnormal_eyelid_morphology0.72133525
93MP0009053_abnormal_anal_canal0.71268194
94MP0002295_abnormal_pulmonary_circulatio0.68567789
95MP0006036_abnormal_mitochondrial_physio0.68536509
96MP0002092_abnormal_eye_morphology0.68531806
97MP0005332_abnormal_amino_acid0.68363776
98MP0003567_abnormal_fetal_cardiomyocyte0.65102542
99MP0009703_decreased_birth_body0.64423059
100MP0001919_abnormal_reproductive_system0.64135136

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.38280554
2Amelogenesis imperfecta (HP:0000705)3.94284487
3Abnormality of the distal phalanges of the toes (HP:0010182)3.76042082
4Trismus (HP:0000211)3.64888809
5Truncus arteriosus (HP:0001660)3.63986077
6Hypergonadotropic hypogonadism (HP:0000815)3.53927545
7Tongue fasciculations (HP:0001308)3.35855335
8Cerebellar dysplasia (HP:0007033)3.35491238
9Micronodular cirrhosis (HP:0001413)3.19054363
10Muscle fibrillation (HP:0010546)3.14689503
11Pili torti (HP:0003777)3.13441666
12Hypokinesia (HP:0002375)3.09946865
13Testicular atrophy (HP:0000029)3.03272785
14Congenital ichthyosiform erythroderma (HP:0007431)3.01362289
15Progressive muscle weakness (HP:0003323)2.98973758
16Abnormality of pyrimidine metabolism (HP:0004353)2.96961182
17Distal lower limb muscle weakness (HP:0009053)2.74832571
18Upper limb muscle weakness (HP:0003484)2.68703397
19Abnormal auditory evoked potentials (HP:0006958)2.64231395
20Hyperthyroidism (HP:0000836)2.62778548
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.51533592
22Abnormal hair laboratory examination (HP:0003328)2.46810972
23Hyperacusis (HP:0010780)2.45010767
24Abnormality of permanent molar morphology (HP:0011071)2.43833119
25Abnormality of the dental root (HP:0006486)2.43833119
26Taurodontia (HP:0000679)2.43833119
27Abnormal pupillary function (HP:0007686)2.41271118
28Short nail (HP:0001799)2.40377522
29Nonimmune hydrops fetalis (HP:0001790)2.38775979
30Bilateral microphthalmos (HP:0007633)2.37814775
31Hypoparathyroidism (HP:0000829)2.36379101
32Fragile nails (HP:0001808)2.35233114
33Alkalosis (HP:0001948)2.33745035
34Abnormality of glycolysis (HP:0004366)2.32737373
35Fasciculations (HP:0002380)2.29614969
36Abdominal distention (HP:0003270)2.29338281
37Hypoplastic pelvis (HP:0008839)2.29098830
38Increased serum pyruvate (HP:0003542)2.28737001
39Entropion (HP:0000621)2.28228158
40Popliteal pterygium (HP:0009756)2.28068455
41Capillary hemangiomas (HP:0005306)2.27784946
42Median cleft lip (HP:0000161)2.23737742
43Abnormality of the aortic arch (HP:0012303)2.21264550
44Back pain (HP:0003418)2.21179965
45Abnormality of pain sensation (HP:0010832)2.17505392
46Impaired pain sensation (HP:0007328)2.17505392
47Facial cleft (HP:0002006)2.16907968
48Conjugated hyperbilirubinemia (HP:0002908)2.16640436
49Curly hair (HP:0002212)2.15239684
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.14576719
51Abnormality of glycolipid metabolism (HP:0010969)2.14576719
52Abnormality of liposaccharide metabolism (HP:0010968)2.14576719
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14345744
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14155086
55Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14155086
56Hypoplasia of the uterus (HP:0000013)2.12174230
57Spastic paraparesis (HP:0002313)2.11544796
58Abnormality of molar morphology (HP:0011070)2.10921857
59Abnormality of molar (HP:0011077)2.10921857
60Ankle contracture (HP:0006466)2.09520849
61Ragged-red muscle fibers (HP:0003200)2.09323745
62Type I transferrin isoform profile (HP:0003642)2.08304587
63Abnormality of the dental pulp (HP:0006479)2.04166959
64Hypoplasia of the thymus (HP:0000778)2.02873244
65Renal tubular acidosis (HP:0001947)2.02684550
66High anterior hairline (HP:0009890)2.01465587
67Female pseudohermaphroditism (HP:0010458)2.00557943
68Microvesicular hepatic steatosis (HP:0001414)1.97836737
69Sparse eyelashes (HP:0000653)1.97708146
70Wide intermamillary distance (HP:0006610)1.96877454
71Loss of speech (HP:0002371)1.96261582
72Distal lower limb amyotrophy (HP:0008944)1.94035720
73Overlapping toe (HP:0001845)1.93418537
74Aplasia cutis congenita (HP:0001057)1.92895302
75Bicornuate uterus (HP:0000813)1.91807117
76Aplasia/hypoplasia of the uterus (HP:0008684)1.91364339
77Hypoplastic labia majora (HP:0000059)1.91121152
78Abnormality of dental color (HP:0011073)1.90128386
79Reduced subcutaneous adipose tissue (HP:0003758)1.90106919
80Partial agenesis of the corpus callosum (HP:0001338)1.89198973
81Hyperammonemia (HP:0001987)1.87989357
82Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87543172
83Woolly hair (HP:0002224)1.86777696
84Hypotrichosis (HP:0001006)1.86427913
85Paraparesis (HP:0002385)1.85782411
86Cerebral edema (HP:0002181)1.83134378
87Abnormality of glutamine family amino acid metabolism (HP:0010902)1.82317544
88Acanthosis nigricans (HP:0000956)1.81988089
89Increased connective tissue (HP:0009025)1.79400472
90Focal segmental glomerulosclerosis (HP:0000097)1.78630538
91Abnormal large intestine physiology (HP:0012700)1.78490159
92Alopecia of scalp (HP:0002293)1.76798101
93Absent thumb (HP:0009777)1.75895594
94Abnormality of the labia majora (HP:0012881)1.75811482
95Bowel incontinence (HP:0002607)1.71942804
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71816724
97Palpitations (HP:0001962)1.69490464
98Vascular calcification (HP:0004934)1.69132236
99Seborrheic dermatitis (HP:0001051)1.68798915
100Cutaneous melanoma (HP:0012056)1.67661392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.80069177
2PBK4.71313776
3ERBB43.77345493
4MST43.62813775
5MST1R3.12008094
6SMG12.85709576
7NME22.65898344
8NME12.60215837
9SIK12.56733887
10LATS12.45280445
11ICK2.20789818
12KDR2.02398716
13DAPK22.02060492
14LATS22.01810058
15MAP3K21.99008514
16BUB11.88365604
17MET1.87625075
18RPS6KB21.84632936
19DAPK11.81074978
20STK381.61373689
21MAP2K21.59736992
22VRK21.58346616
23TESK21.53935162
24MAP3K31.48184351
25EPHB11.42717178
26MAP3K121.42177636
27STK38L1.33456771
28STK101.32582922
29EIF2AK11.30177301
30MAP3K91.28401906
31PAK41.26791329
32WNK41.25750475
33PDK21.19292948
34IRAK31.18263138
35AKT21.17259796
36AURKB1.08137306
37STK391.05444363
38PRKG21.04126719
39BRSK21.02799545
40PTK20.97651428
41MAP2K10.95954242
42SIK30.90130045
43PRKCI0.89271204
44PINK10.86645393
45MAP3K80.85182067
46LRRK20.83916649
47CDK80.83085317
48SRPK10.81818003
49AURKA0.78045673
50FER0.74536292
51RIPK10.71989317
52CAMK2G0.71346519
53OXSR10.71298227
54MTOR0.67449641
55CDK70.67005783
56WEE10.62695752
57RPS6KA40.62286432
58DAPK30.60709576
59TRIM280.60191384
60MAPK110.58748685
61CHEK20.57805548
62NEK10.57301481
63PDGFRA0.56294606
64NTRK10.56224331
65TESK10.53651012
66PIM20.53134019
67MAPKAPK50.52622154
68RAF10.51351417
69STK160.50836355
70DYRK30.50011475
71STK40.49339040
72TTK0.49333829
73LMTK20.49136329
74CAMK2D0.48083235
75CAMK2B0.47469836
76MAP3K10.46434182
77BRSK10.43299328
78PLK10.43156042
79NEK20.39757177
80CSNK1A1L0.37124207
81SCYL20.36821567
82STK30.35737467
83ARAF0.33657906
84MAP3K70.32592289
85CHEK10.32087725
86MAP2K60.31596700
87YES10.31058941
88RPS6KA20.29663251
89ERN10.29444255
90EPHA30.26823179
91KSR10.25990168
92SRC0.25905553
93ABL20.25111927
94PIM10.23548811
95CSNK1G30.23477512
96CDK90.23245493
97NEK90.22803401
98EGFR0.22576168
99KSR20.20491136
100RPS6KA10.20433347

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.96444001
2Steroid hormone biosynthesis_Homo sapiens_hsa001403.63073478
3Pentose phosphate pathway_Homo sapiens_hsa000303.44167946
4Ovarian steroidogenesis_Homo sapiens_hsa049132.82520099
5Selenocompound metabolism_Homo sapiens_hsa004502.50917388
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.47900460
7* Folate biosynthesis_Homo sapiens_hsa007902.34128960
8Thyroid cancer_Homo sapiens_hsa052162.14193022
9Biosynthesis of amino acids_Homo sapiens_hsa012302.09866630
10Galactose metabolism_Homo sapiens_hsa000521.98402304
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97579630
12Fructose and mannose metabolism_Homo sapiens_hsa000511.95320037
13N-Glycan biosynthesis_Homo sapiens_hsa005101.83492655
14Carbon metabolism_Homo sapiens_hsa012001.83419569
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.67791335
16Glutathione metabolism_Homo sapiens_hsa004801.61950338
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59417864
18Pyruvate metabolism_Homo sapiens_hsa006201.56685313
19Nucleotide excision repair_Homo sapiens_hsa034201.56672610
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56435497
21DNA replication_Homo sapiens_hsa030301.53429550
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52299228
23Mismatch repair_Homo sapiens_hsa034301.49209102
24Fatty acid elongation_Homo sapiens_hsa000621.42388783
25Fatty acid biosynthesis_Homo sapiens_hsa000611.40831345
26Basal cell carcinoma_Homo sapiens_hsa052171.37629844
27Phenylalanine metabolism_Homo sapiens_hsa003601.36157936
28One carbon pool by folate_Homo sapiens_hsa006701.35778727
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.35381311
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25551740
31Hedgehog signaling pathway_Homo sapiens_hsa043401.23551937
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22303730
33Hippo signaling pathway_Homo sapiens_hsa043901.21715133
34Homologous recombination_Homo sapiens_hsa034401.16453924
35Arginine biosynthesis_Homo sapiens_hsa002201.16274362
36Pyrimidine metabolism_Homo sapiens_hsa002401.15398195
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11801242
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.10447771
39Sulfur relay system_Homo sapiens_hsa041221.09180358
40Sphingolipid metabolism_Homo sapiens_hsa006001.07523757
41Fatty acid metabolism_Homo sapiens_hsa012121.07083537
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06725856
43Spliceosome_Homo sapiens_hsa030401.05711156
44Small cell lung cancer_Homo sapiens_hsa052221.03038621
45RNA transport_Homo sapiens_hsa030130.99024766
46Ribosome_Homo sapiens_hsa030100.98805342
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95965822
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94132662
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92799470
50Tight junction_Homo sapiens_hsa045300.92504591
51Chemical carcinogenesis_Homo sapiens_hsa052040.91009993
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89852800
53Base excision repair_Homo sapiens_hsa034100.84790948
54Bladder cancer_Homo sapiens_hsa052190.84525153
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84083723
56Collecting duct acid secretion_Homo sapiens_hsa049660.81030187
57Vibrio cholerae infection_Homo sapiens_hsa051100.77930667
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76896952
59* Metabolic pathways_Homo sapiens_hsa011000.76045525
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73246856
61Cell cycle_Homo sapiens_hsa041100.71043564
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70325596
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67682644
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67204249
65Histidine metabolism_Homo sapiens_hsa003400.66997458
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.64598791
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64236703
68Vitamin B6 metabolism_Homo sapiens_hsa007500.62555104
69Regulation of autophagy_Homo sapiens_hsa041400.62524711
70AMPK signaling pathway_Homo sapiens_hsa041520.60250504
71Non-homologous end-joining_Homo sapiens_hsa034500.59512225
72Oxidative phosphorylation_Homo sapiens_hsa001900.58880969
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58567852
74Tyrosine metabolism_Homo sapiens_hsa003500.57945665
75mRNA surveillance pathway_Homo sapiens_hsa030150.56591878
76Fanconi anemia pathway_Homo sapiens_hsa034600.56466535
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55216997
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54294365
79Mineral absorption_Homo sapiens_hsa049780.52407971
80Steroid biosynthesis_Homo sapiens_hsa001000.51977521
81Peroxisome_Homo sapiens_hsa041460.46675601
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46350964
83ABC transporters_Homo sapiens_hsa020100.46338552
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45861342
85ECM-receptor interaction_Homo sapiens_hsa045120.45853762
86Tryptophan metabolism_Homo sapiens_hsa003800.45355923
87Proteoglycans in cancer_Homo sapiens_hsa052050.43867922
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42487200
89Basal transcription factors_Homo sapiens_hsa030220.42303580
90Starch and sucrose metabolism_Homo sapiens_hsa005000.41646052
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40654679
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39055605
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37010406
94Melanogenesis_Homo sapiens_hsa049160.34584778
95Glucagon signaling pathway_Homo sapiens_hsa049220.34248132
96Vitamin digestion and absorption_Homo sapiens_hsa049770.33711168
97Parkinsons disease_Homo sapiens_hsa050120.32575973
98Pathways in cancer_Homo sapiens_hsa052000.31104830
99Adherens junction_Homo sapiens_hsa045200.30539514
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30376584

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