ALPK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.40531071
2cardiac myofibril assembly (GO:0055003)6.58376152
3myofibril assembly (GO:0030239)6.37097292
4muscle filament sliding (GO:0030049)6.28670959
5actin-myosin filament sliding (GO:0033275)6.28670959
6cardiac muscle cell development (GO:0055013)5.42575183
7regulation of relaxation of muscle (GO:1901077)5.32783793
8heart process (GO:0003015)5.32018531
9heart contraction (GO:0060047)5.32018531
10sequestering of extracellular ligand from receptor (GO:0035581)5.25663241
11actin-mediated cell contraction (GO:0070252)5.22029792
12regulation of skeletal muscle contraction (GO:0014819)5.20641663
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.15623289
14cardiac muscle contraction (GO:0060048)5.13108507
15regulation of cardioblast differentiation (GO:0051890)5.10201706
16cardiac cell development (GO:0055006)5.09660145
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.09506109
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.99333662
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.99331124
20cardiac muscle tissue morphogenesis (GO:0055008)4.88876465
21bone trabecula formation (GO:0060346)4.72813864
22regulation of actin filament-based movement (GO:1903115)4.68071731
23ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.65199394
24cardiac chamber formation (GO:0003207)4.59784713
25adult heart development (GO:0007512)4.53192515
26DNA deamination (GO:0045006)4.52902058
27cell communication by electrical coupling (GO:0010644)4.49941326
28tricarboxylic acid cycle (GO:0006099)4.49282432
29actomyosin structure organization (GO:0031032)4.46659647
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.46327614
31negative regulation of potassium ion transmembrane transport (GO:1901380)4.40502990
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.36323055
33muscle tissue morphogenesis (GO:0060415)4.33031350
34striated muscle contraction (GO:0006941)4.31078304
35mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30200672
36oxidative phosphorylation (GO:0006119)4.30103381
37sarcoplasmic reticulum calcium ion transport (GO:0070296)4.24545673
38cardiac muscle hypertrophy (GO:0003300)4.20104155
39bundle of His cell to Purkinje myocyte communication (GO:0086069)4.19890905
40energy coupled proton transport, down electrochemical gradient (GO:0015985)4.16920352
41ATP synthesis coupled proton transport (GO:0015986)4.16920352
42regulation of sarcomere organization (GO:0060297)4.13478850
43regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.10141285
44cell migration involved in heart development (GO:0060973)4.07997082
45atrial septum morphogenesis (GO:0060413)4.03911316
46positive regulation of cardiac muscle cell differentiation (GO:2000727)3.95549500
47striated muscle hypertrophy (GO:0014897)3.95448993
48response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.94175365
49respiratory electron transport chain (GO:0022904)3.94116463
50pericardium development (GO:0060039)3.93860257
51ventricular cardiac muscle cell action potential (GO:0086005)3.92230348
52regulation of striated muscle contraction (GO:0006942)3.86625116
53collagen fibril organization (GO:0030199)3.83840345
54electron transport chain (GO:0022900)3.80503562
55regulation of cell communication by electrical coupling (GO:0010649)3.79101656
56venous blood vessel morphogenesis (GO:0048845)3.78474969
57negative regulation of myotube differentiation (GO:0010832)3.73579868
58positive regulation of cardiac muscle tissue development (GO:0055025)3.72486410
59ubiquinone biosynthetic process (GO:0006744)3.67249132
60quinone biosynthetic process (GO:1901663)3.67249132
61atrioventricular valve morphogenesis (GO:0003181)3.64883129
62cardiac ventricle formation (GO:0003211)3.62563342
63endocardial cushion development (GO:0003197)3.62196897
64positive regulation of cardiac muscle cell proliferation (GO:0060045)3.61726108
65regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.61465051
66regulation of acyl-CoA biosynthetic process (GO:0050812)3.60614938
67muscle hypertrophy (GO:0014896)3.59688018
68regulation of cardiac muscle cell differentiation (GO:2000725)3.56069598
69actin filament-based movement (GO:0030048)3.51986759
70regulation of mitochondrial translation (GO:0070129)3.48564803
71positive regulation of cardiac muscle tissue growth (GO:0055023)3.44266311
72regulation of coenzyme metabolic process (GO:0051196)3.43382953
73regulation of cofactor metabolic process (GO:0051193)3.43382953
74regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.42784192
75outflow tract septum morphogenesis (GO:0003148)3.41670160
76plasma membrane repair (GO:0001778)3.38977069
77cell communication involved in cardiac conduction (GO:0086065)3.38702074
78regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.37976896
79telomere maintenance via semi-conservative replication (GO:0032201)3.36618057
80ventricular cardiac muscle cell development (GO:0055015)3.30848695
81skeletal muscle contraction (GO:0003009)3.29290731
82negative regulation of striated muscle cell apoptotic process (GO:0010664)3.29208291
83heart trabecula formation (GO:0060347)3.27477986
84regulation of the force of heart contraction (GO:0002026)3.27415211
85positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.26058260
86negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.22002333
87mitochondrial DNA replication (GO:0006264)3.20828759
88cardiac muscle hypertrophy in response to stress (GO:0014898)3.19393884
89muscle hypertrophy in response to stress (GO:0003299)3.19393884
90cardiac muscle adaptation (GO:0014887)3.19393884
91regulation of transforming growth factor beta2 production (GO:0032909)3.17119437
92regulation of cardiac muscle tissue development (GO:0055024)3.16470854
93regulation of ATPase activity (GO:0043462)3.16098808
94regulation of ATP catabolic process (GO:1903289)3.16098808
95negative regulation of hormone biosynthetic process (GO:0032353)3.15169545
96regulation of glucocorticoid metabolic process (GO:0031943)3.14975306
97endocardial cushion morphogenesis (GO:0003203)3.13433074
98regulation of cardiac muscle contraction (GO:0055117)3.12252086
99ubiquinone metabolic process (GO:0006743)3.10469643
100carnitine shuttle (GO:0006853)3.09988172
101trabecula formation (GO:0060343)3.09806303
102positive regulation of heart growth (GO:0060421)3.07889295
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.07470344
104proteasome assembly (GO:0043248)3.07123591
105regulation of myoblast differentiation (GO:0045661)3.04971246
106protein heterotrimerization (GO:0070208)3.00932889
107striated muscle cell development (GO:0055002)3.00595293
108telomere maintenance via recombination (GO:0000722)3.00526896
109ribosome assembly (GO:0042255)2.99021507
110response to inactivity (GO:0014854)2.98024997
111regulation of skeletal muscle cell differentiation (GO:2001014)2.96296394
112endodermal cell differentiation (GO:0035987)2.96015667
113muscle contraction (GO:0006936)2.95795544
114extracellular regulation of signal transduction (GO:1900115)2.95148710
115extracellular negative regulation of signal transduction (GO:1900116)2.95148710
116desmosome organization (GO:0002934)2.94755352
117negative regulation of skeletal muscle tissue development (GO:0048642)2.93894259
118rRNA modification (GO:0000154)2.93601384
119relaxation of muscle (GO:0090075)2.93185656
120regulation of nuclear cell cycle DNA replication (GO:0033262)2.90122789
121positive regulation of myoblast differentiation (GO:0045663)2.89855941
122cellular response to epinephrine stimulus (GO:0071872)2.89208585
123positive regulation of heart contraction (GO:0045823)2.88264510
124regulation of membrane repolarization (GO:0060306)2.87413617
125aerobic respiration (GO:0009060)2.86961868
126regulation of cardiac muscle cell contraction (GO:0086004)2.86180030
127response to epinephrine (GO:0071871)2.85758955
128negative regulation of protein localization to cell surface (GO:2000009)2.85624679
129regulation of heart rate (GO:0002027)2.85237852
130mesenchyme morphogenesis (GO:0072132)2.84780492
131regulation of cardiac muscle cell apoptotic process (GO:0010665)2.84325097
132positive regulation of heart rate (GO:0010460)2.83713874
133DNA replication checkpoint (GO:0000076)2.80780513
134cardiac septum development (GO:0003279)2.80666603
135negative regulation of hormone metabolic process (GO:0032351)2.80615297
136regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.79968038
137relaxation of cardiac muscle (GO:0055119)2.76140401
138regulation of cellular respiration (GO:0043457)2.75323197
139DNA-dependent DNA replication (GO:0006261)2.74760241
140regulation of striated muscle cell apoptotic process (GO:0010662)2.73710102
141cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73097542
142skeletal muscle tissue regeneration (GO:0043403)2.72163498
143cellular response to zinc ion (GO:0071294)2.71665321
144regulation of sulfur metabolic process (GO:0042762)2.71191051
145cardiac muscle cell action potential (GO:0086001)2.70100398
146NADH metabolic process (GO:0006734)2.69486162
147DNA strand elongation involved in DNA replication (GO:0006271)2.69447841
148cardiac muscle cell action potential involved in contraction (GO:0086002)2.68851326
149protein complex biogenesis (GO:0070271)2.63674888
150oxygen transport (GO:0015671)2.63672593
151negative regulation of nitric-oxide synthase activity (GO:0051001)2.63607481
152cytochrome complex assembly (GO:0017004)2.62376894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.65776025
2E2F7_22180533_ChIP-Seq_HELA_Human4.45714240
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38843239
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.67743717
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60964831
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.55573384
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.54442505
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.45323616
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.39116399
10WT1_19549856_ChIP-ChIP_CCG9911_Human3.27939382
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16810258
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.14318300
13CDX2_19796622_ChIP-Seq_MESCs_Mouse3.03567919
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.97302873
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.94162022
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76082944
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.65764956
18ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.59059761
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57864885
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57515291
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50177549
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49918690
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.47851497
24RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47427747
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41971566
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.36895324
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31419292
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29126764
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28165543
30VDR_23849224_ChIP-Seq_CD4+_Human2.27158622
31GBX2_23144817_ChIP-Seq_PC3_Human2.24498457
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18878611
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09889421
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.09255823
35MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.09194679
36* CJUN_26792858_Chip-Seq_BT549_Human2.07572137
37NOTCH1_21737748_ChIP-Seq_TLL_Human2.06406717
38BRD4_25478319_ChIP-Seq_HGPS_Human2.05056975
39GATA4_21415370_ChIP-Seq_HL-1_Mouse2.00529685
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99438150
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.98588051
42NRF2_20460467_ChIP-Seq_MEFs_Mouse1.98588051
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.95791721
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93307908
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92495173
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91775554
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88957887
48TP53_16413492_ChIP-PET_HCT116_Human1.88789735
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88267636
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87134158
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85220985
52FOXP3_21729870_ChIP-Seq_TREG_Human1.84901366
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84248351
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82903261
55CIITA_25753668_ChIP-Seq_RAJI_Human1.82640418
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.82111756
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81763584
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81504605
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80405183
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76981576
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76772194
62BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.74004557
63TP53_18474530_ChIP-ChIP_U2OS_Human1.72076613
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69921655
65DCP1A_22483619_ChIP-Seq_HELA_Human1.67981020
66ELK1_19687146_ChIP-ChIP_HELA_Human1.65852414
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.65736223
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64976022
69* PIAS1_25552417_ChIP-Seq_VCAP_Human1.60876489
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58716969
71EZH2_22144423_ChIP-Seq_EOC_Human1.55956792
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.55326772
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55203178
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55163911
75EP300_21415370_ChIP-Seq_HL-1_Mouse1.54589581
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52805622
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52717366
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52660139
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51158084
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50601767
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50421598
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49122555
83GATA1_22025678_ChIP-Seq_K562_Human1.48361597
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48109887
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48109887
86XRN2_22483619_ChIP-Seq_HELA_Human1.47337733
87* TBX20_22328084_ChIP-Seq_HEART_Mouse1.47088786
88* TBX20_22080862_ChIP-Seq_HEART_Mouse1.47088786
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46562630
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45298640
91TTF2_22483619_ChIP-Seq_HELA_Human1.41150687
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40713935
93GABP_19822575_ChIP-Seq_HepG2_Human1.40088745
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39356579
95SMAD4_21799915_ChIP-Seq_A2780_Human1.39343839
96TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39287198
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38627698
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37322803
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36968864
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36391108
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35776606
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35354842
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.34128837
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.33702556
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.33646183
106HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33628413
107* SMAD3_21741376_ChIP-Seq_HESCs_Human1.33438412
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32588706
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32313030
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31435176
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31360738
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31096740
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30845289
114MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30714537
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.30700390
116* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.28933089
117SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28861388
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26735770
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26427386
120CLOCK_20551151_ChIP-Seq_293T_Human1.25581917
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24660440
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22526682
123FOXM1_23109430_ChIP-Seq_U2OS_Human1.22296925
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21377002
125JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21136522
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20822785
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20705632
128ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20508407
129GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20468361
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19873009
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19393863
132HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19038733
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18794762
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15138834
135NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14616417
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14063044
137MTF2_20144788_ChIP-Seq_MESCs_Mouse1.13747817
138YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12442833
139AHR_22903824_ChIP-Seq_MCF-7_Human1.11743094
140GATA2_21666600_ChIP-Seq_HMVEC_Human1.11646674
141TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10527718
142IRF8_21731497_ChIP-ChIP_J774_Mouse1.10172870
143SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09299401
144E2F1_21310950_ChIP-Seq_MCF-7_Human1.08811921
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.08641572
146* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08304997
147SPI1_23547873_ChIP-Seq_NB4_Human1.08224780
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07585903
149ARNT_22903824_ChIP-Seq_MCF-7_Human1.05041626
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03466957
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03058878
152NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02908121
153ELK1_22589737_ChIP-Seq_MCF10A_Human1.02867260
154RNF2_27304074_Chip-Seq_ESCs_Mouse1.01066296
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00836246
156TBX5_21415370_ChIP-Seq_HL-1_Mouse1.00029380
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99124499
158* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99081287
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97897532
160SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97897532
161MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97787342
162ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97638580
163PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96911666
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96683472
165YY1_22570637_ChIP-Seq_MALME-3M_Human0.96462365
166SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96049176
167TAF15_26573619_Chip-Seq_HEK293_Human0.95112573
168LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94651270
169SOX9_26525672_Chip-Seq_HEART_Mouse0.94594604
170CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94238781
171PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94021809
172JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93439519
173TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93355801
174PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93092594
175POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92885330
176PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92883210
177TP63_19390658_ChIP-ChIP_HaCaT_Human0.91902678
178JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91687200
179SOX2_21211035_ChIP-Seq_LN229_Gbm0.91470873
180FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91105627
181GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90679567
182STAT3_23295773_ChIP-Seq_U87_Human0.90324397
183IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88824711
184POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88563618
185EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86857084
186LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86156450
187RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83507484
188STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78631746
189IRF8_22096565_ChIP-ChIP_GC-B_Human0.77617710
190HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74796605
191ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74704614
192FLI1_27457419_Chip-Seq_LIVER_Mouse0.74064959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.09187826
2MP0002837_dystrophic_cardiac_calcinosis5.85520015
3MP0004084_abnormal_cardiac_muscle5.36797387
4MP0008438_abnormal_cutaneous_collagen4.88085138
5MP0004215_abnormal_myocardial_fiber4.38035157
6MP0000751_myopathy4.28808843
7MP0000749_muscle_degeneration3.92257631
8MP0004036_abnormal_muscle_relaxation3.77382505
9MP0005330_cardiomyopathy3.66636250
10MP0004272_abnormal_basement_membrane3.10869852
11MP0005503_abnormal_tendon_morphology2.96714545
12MP0002972_abnormal_cardiac_muscle2.84145121
13MP0003137_abnormal_impulse_conducting2.69998948
14MP0004087_abnormal_muscle_fiber2.64472472
15MP0001958_emphysema2.63122461
16MP0003828_pulmonary_edema2.60314539
17MP0000750_abnormal_muscle_regeneration2.56065578
18MP0003705_abnormal_hypodermis_morpholog2.54100482
19MP0002106_abnormal_muscle_physiology2.47932038
20MP0005620_abnormal_muscle_contractility2.46962565
21MP0005275_abnormal_skin_tensile2.44510031
22MP0008775_abnormal_heart_ventricle2.42812219
23MP0009384_cardiac_valve_regurgitation2.41197496
24MP0005385_cardiovascular_system_phenoty2.37556518
25MP0001544_abnormal_cardiovascular_syste2.37556518
26MP0004510_myositis2.31730175
27MP0010630_abnormal_cardiac_muscle2.31218663
28MP0002269_muscular_atrophy2.25196953
29MP0004484_altered_response_of2.21678861
30MP0004145_abnormal_muscle_electrophysio2.20216555
31MP0003221_abnormal_cardiomyocyte_apopto1.96450805
32MP0006138_congestive_heart_failure1.94196769
33MP0005369_muscle_phenotype1.92939730
34MP0006036_abnormal_mitochondrial_physio1.90854107
35MP0005623_abnormal_meninges_morphology1.78743488
36MP0003567_abnormal_fetal_cardiomyocyte1.76177154
37MP0002127_abnormal_cardiovascular_syste1.72421549
38MP0000759_abnormal_skeletal_muscle1.69822865
39MP0004085_abnormal_heartbeat1.63348938
40MP0000733_abnormal_muscle_development1.62013886
41MP0003566_abnormal_cell_adhesion1.58867401
42MP0001853_heart_inflammation1.56468412
43MP0005257_abnormal_intraocular_pressure1.46304513
44MP0009250_abnormal_appendicular_skeleto1.42701415
45MP0000343_altered_response_to1.42519660
46MP0006054_spinal_hemorrhage1.41311136
47MP0004130_abnormal_muscle_cell1.39919927
48MP0000747_muscle_weakness1.37579400
49MP0008057_abnormal_DNA_replication1.37164883
50MP0003950_abnormal_plasma_membrane1.36607952
51MP0003941_abnormal_skin_development1.35579115
52MP0008058_abnormal_DNA_repair1.35377259
53MP0002332_abnormal_exercise_endurance1.35246138
54MP0000534_abnormal_ureter_morphology1.34307220
55MP0000013_abnormal_adipose_tissue1.34178855
56MP0003693_abnormal_embryo_hatching1.32761202
57MP0003091_abnormal_cell_migration1.32490186
58MP0006035_abnormal_mitochondrial_morpho1.30878697
59MP0001661_extended_life_span1.30462215
60MP0001299_abnormal_eye_distance/1.30229011
61MP0005670_abnormal_white_adipose1.26563297
62MP0003385_abnormal_body_wall1.20086009
63MP0003111_abnormal_nucleus_morphology1.18822821
64MP0000462_abnormal_digestive_system1.16561091
65MP0010094_abnormal_chromosome_stability1.15117729
66MP0005508_abnormal_skeleton_morphology1.08460562
67MP0002102_abnormal_ear_morphology1.07481058
68MP0003077_abnormal_cell_cycle1.06816238
69MP0005165_increased_susceptibility_to1.04612852
70MP0002295_abnormal_pulmonary_circulatio1.04313187
71MP0008877_abnormal_DNA_methylation1.02405949
72MP0005451_abnormal_body_composition1.00726563
73MP0005023_abnormal_wound_healing1.00668911
74MP0001542_abnormal_bone_strength0.99418118
75MP0000266_abnormal_heart_morphology0.97142955
76MP0005266_abnormal_metabolism0.96494220
77MP0003045_fibrosis0.94663594
78MP0003937_abnormal_limbs/digits/tail_de0.92334978
79MP0008007_abnormal_cellular_replicative0.90831736
80MP0003942_abnormal_urinary_system0.90468117
81MP0004233_abnormal_muscle_weight0.88841484
82MP0009780_abnormal_chondrocyte_physiolo0.87385957
83MP0003786_premature_aging0.84185329
84MP0002896_abnormal_bone_mineralization0.82734011
85MP0003186_abnormal_redox_activity0.80911654
86MP0001348_abnormal_lacrimal_gland0.80751178
87MP0010030_abnormal_orbit_morphology0.78510405
88MP0002148_abnormal_hypersensitivity_rea0.77323512
89MP0005595_abnormal_vascular_smooth0.77130339
90MP0009053_abnormal_anal_canal0.76635310
91MP0003279_aneurysm0.76141192
92MP0002396_abnormal_hematopoietic_system0.75869684
93MP0002925_abnormal_cardiovascular_devel0.75375664
94MP0001835_abnormal_antigen_presentation0.74993538
95MP0001614_abnormal_blood_vessel0.74727441
96MP0000762_abnormal_tongue_morphology0.71941547
97MP0002168_other_aberrant_phenotype0.69474542
98MP0002234_abnormal_pharynx_morphology0.68826282
99MP0003935_abnormal_craniofacial_develop0.67176105
100MP0009785_altered_susceptibility_to0.66444164
101MP0002115_abnormal_skeleton_extremities0.65585938
102MP0004134_abnormal_chest_morphology0.65226926
103MP0000566_synostosis0.65186914
104MP0004858_abnormal_nervous_system0.64999502
105MP0002060_abnormal_skin_morphology0.61544555
106MP0000428_abnormal_craniofacial_morphol0.61433048
107MP0005248_abnormal_Harderian_gland0.60923366
108MP0005666_abnormal_adipose_tissue0.60339322
109MP0008995_early_reproductive_senescence0.60309313
110MP0003806_abnormal_nucleotide_metabolis0.59784421
111MP0000003_abnormal_adipose_tissue0.59186550
112MP0004147_increased_porphyrin_level0.58783252
113MP0003984_embryonic_growth_retardation0.58521671
114MP0003718_maternal_effect0.58071465
115MP0001243_abnormal_dermal_layer0.57446339
116MP0004957_abnormal_blastocyst_morpholog0.57287322
117MP0002877_abnormal_melanocyte_morpholog0.56393233
118MP0010352_gastrointestinal_tract_polyps0.55186927
119MP0002088_abnormal_embryonic_growth/wei0.54797877
120MP0008932_abnormal_embryonic_tissue0.54548736
121MP0006292_abnormal_olfactory_placode0.54425618
122MP0005409_darkened_coat_color0.54059383
123MP0000230_abnormal_systemic_arterial0.53731104
124MP0005197_abnormal_uvea_morphology0.53676905
125MP0000163_abnormal_cartilage_morphology0.53518014
126MP0002114_abnormal_axial_skeleton0.53417127
127MP0001188_hyperpigmentation0.53306693
128MP0002932_abnormal_joint_morphology0.53101961
129MP0010368_abnormal_lymphatic_system0.53031080
130MP0003283_abnormal_digestive_organ0.52875958
131MP0003755_abnormal_palate_morphology0.52800697
132MP0003763_abnormal_thymus_physiology0.51997901
133MP0002128_abnormal_blood_circulation0.51994077
134MP0005075_abnormal_melanosome_morpholog0.51886867
135MP0000313_abnormal_cell_death0.50195323
136MP0000372_irregular_coat_pigmentation0.49842896
137MP0004808_abnormal_hematopoietic_stem0.49096091
138MP0000767_abnormal_smooth_muscle0.46213935
139MP0009697_abnormal_copulation0.45565885
140MP0000015_abnormal_ear_pigmentation0.44960404
141MP0005380_embryogenesis_phenotype0.44647862
142MP0001672_abnormal_embryogenesis/_devel0.44647862
143MP0005171_absent_coat_pigmentation0.39559044
144MP0005025_abnormal_response_to0.39298132
145MP0009333_abnormal_splenocyte_physiolog0.38820427
146MP0002108_abnormal_muscle_morphology0.37794429
147MP0000358_abnormal_cell_content/0.36533539
148MP0002210_abnormal_sex_determination0.35927033
149MP0001986_abnormal_taste_sensitivity0.34989147
150MP0001879_abnormal_lymphatic_vessel0.34238026
151MP0008260_abnormal_autophagy0.33167960
152MP0004381_abnormal_hair_follicle0.31576913
153MP0002419_abnormal_innate_immunity0.31082790
154MP0002160_abnormal_reproductive_system0.30801314
155MP0001186_pigmentation_phenotype0.30198542

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.91098022
2Ventricular tachycardia (HP:0004756)6.32647396
3Calf muscle hypertrophy (HP:0008981)5.55258466
4Atrial fibrillation (HP:0005110)5.38028928
5Premature rupture of membranes (HP:0001788)5.26862066
6Muscle hypertrophy of the lower extremities (HP:0008968)5.05940244
7Lipoatrophy (HP:0100578)5.02681652
8Primary atrial arrhythmia (HP:0001692)4.96041305
9Supraventricular tachycardia (HP:0004755)4.93127952
10Protrusio acetabuli (HP:0003179)4.90978848
11Muscle fiber splitting (HP:0003555)4.90509984
12Subaortic stenosis (HP:0001682)4.83792857
13Abnormality of the left ventricular outflow tract (HP:0011103)4.83792857
14Supraventricular arrhythmia (HP:0005115)4.78595883
15Exercise-induced muscle cramps (HP:0003710)4.64423801
16Abnormality of the calf musculature (HP:0001430)4.51181110
17Exercise-induced myalgia (HP:0003738)4.37502527
18Aortic dissection (HP:0002647)4.26830512
19Dilated cardiomyopathy (HP:0001644)4.16281451
20Palpitations (HP:0001962)4.14164315
21Syncope (HP:0001279)4.04518008
22Aortic aneurysm (HP:0004942)3.97051989
23Vascular tortuosity (HP:0004948)3.94946102
24Myoglobinuria (HP:0002913)3.88937651
25Hepatic necrosis (HP:0002605)3.82321561
26Right ventricular cardiomyopathy (HP:0011663)3.70958751
27Bundle branch block (HP:0011710)3.69975259
28Arterial tortuosity (HP:0005116)3.61894415
29Acute necrotizing encephalopathy (HP:0006965)3.59737712
30Hepatocellular necrosis (HP:0001404)3.57995008
31Rhabdomyolysis (HP:0003201)3.57569392
32EMG: myopathic abnormalities (HP:0003458)3.48956739
33Abnormal mitochondria in muscle tissue (HP:0008316)3.46484699
34Prolonged QT interval (HP:0001657)3.39333239
35Ventricular arrhythmia (HP:0004308)3.35160113
36Mitochondrial inheritance (HP:0001427)3.34658192
37Hip contracture (HP:0003273)3.33334070
38Exercise intolerance (HP:0003546)3.23841210
39Soft skin (HP:0000977)3.23283390
40Hyporeflexia of lower limbs (HP:0002600)3.20466410
41Increased CSF lactate (HP:0002490)3.19425383
42Heart block (HP:0012722)3.17030698
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.16354564
44Limited hip movement (HP:0008800)3.03154634
45Testicular atrophy (HP:0000029)3.02264432
46Centrally nucleated skeletal muscle fibers (HP:0003687)3.02041102
47Increased variability in muscle fiber diameter (HP:0003557)3.00147525
48Progressive external ophthalmoplegia (HP:0000590)2.98488262
49Atrioventricular block (HP:0001678)2.98408284
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96724967
51Abnormal atrioventricular conduction (HP:0005150)2.96682665
52Mitral valve prolapse (HP:0001634)2.95702783
53Mildly elevated creatine phosphokinase (HP:0008180)2.94885362
54Asymmetric septal hypertrophy (HP:0001670)2.93637199
55Atrophic scars (HP:0001075)2.86166445
56Progressive macrocephaly (HP:0004481)2.84324674
57Spinal rigidity (HP:0003306)2.84272693
58Ventricular fibrillation (HP:0001663)2.83429254
59Acute encephalopathy (HP:0006846)2.78348130
60Abnormality of skeletal muscle fiber size (HP:0012084)2.78073793
61Neonatal short-limb short stature (HP:0008921)2.76592311
62Round ear (HP:0100830)2.76179951
63Progressive muscle weakness (HP:0003323)2.75940232
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.75762958
65Left ventricular hypertrophy (HP:0001712)2.74118378
66Increased intramyocellular lipid droplets (HP:0012240)2.73860780
67Lactic acidosis (HP:0003128)2.73826187
68Abnormal EKG (HP:0003115)2.73198525
69Distal lower limb muscle weakness (HP:0009053)2.72899575
70Dilatation of the ascending aorta (HP:0005111)2.72388877
71Increased connective tissue (HP:0009025)2.72022474
72Increased serum lactate (HP:0002151)2.71456296
73Increased muscle lipid content (HP:0009058)2.71334994
74Ankle contracture (HP:0006466)2.71197493
75Areflexia of lower limbs (HP:0002522)2.71049493
76Muscle fiber inclusion bodies (HP:0100299)2.68924318
77Bladder diverticulum (HP:0000015)2.68376176
78Lipid accumulation in hepatocytes (HP:0006561)2.65784356
79Increased hepatocellular lipid droplets (HP:0006565)2.63710926
80Mitral regurgitation (HP:0001653)2.56846089
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56091436
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56091436
83Abnormality of alanine metabolism (HP:0010916)2.55389892
84Hyperalaninemia (HP:0003348)2.55389892
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55389892
86Myotonia (HP:0002486)2.55143562
87Palmoplantar keratoderma (HP:0000982)2.53574537
88Slender build (HP:0001533)2.50835308
89Fragile skin (HP:0001030)2.49666777
90Wormian bones (HP:0002645)2.44360367
91Spondylolisthesis (HP:0003302)2.44265803
92Proximal tubulopathy (HP:0000114)2.43748339
93Abnormality of dentin (HP:0010299)2.43545373
94Respiratory failure (HP:0002878)2.41405155
95Neck muscle weakness (HP:0000467)2.41365469
96Abnormality of the ischium (HP:0003174)2.38321654
97Peritonitis (HP:0002586)2.36149810
98Ulnar deviation of the wrist (HP:0003049)2.34905717
99Distal arthrogryposis (HP:0005684)2.33572822
100Aneurysm (HP:0002617)2.33198545
101Broad metatarsal (HP:0001783)2.33006392
102Nemaline bodies (HP:0003798)2.30207624
103Pulmonary artery stenosis (HP:0004415)2.30121369
104Exertional dyspnea (HP:0002875)2.25131979
105Duplicated collecting system (HP:0000081)2.24800046
106Rimmed vacuoles (HP:0003805)2.23467223
107Cerebral edema (HP:0002181)2.22541630
108Follicular hyperkeratosis (HP:0007502)2.21300619
109Nausea (HP:0002018)2.20210172
110Type 2 muscle fiber atrophy (HP:0003554)2.20123229
111Ectopia lentis (HP:0001083)2.18240554
112Knee flexion contracture (HP:0006380)2.17998119
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17620201
114Dicarboxylic aciduria (HP:0003215)2.17620201
115Cervical subluxation (HP:0003308)2.14768224
116Wide anterior fontanel (HP:0000260)2.13439801
117Difficulty climbing stairs (HP:0003551)2.11661349
118Hypoplastic ischia (HP:0003175)2.11544106
119Difficulty running (HP:0009046)2.10450130
120Overgrowth (HP:0001548)2.09149674
121Calcaneovalgus deformity (HP:0001848)2.08525702
122Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07944018
123Bradycardia (HP:0001662)2.07934164
124Elbow flexion contracture (HP:0002987)2.07839685
125Shallow orbits (HP:0000586)2.07328218
126Respiratory difficulties (HP:0002880)2.06833386
127Neoplasm of the adrenal gland (HP:0100631)2.05844733
128Bowel diverticulosis (HP:0005222)2.05384290
129Scapular winging (HP:0003691)2.02567627
130Type 1 muscle fiber predominance (HP:0003803)2.00355315
131Muscular dystrophy (HP:0003560)2.00312354
132Birth length less than 3rd percentile (HP:0003561)1.99612641
133Abnormality of the renal collecting system (HP:0004742)1.97551704
134Deformed tarsal bones (HP:0008119)1.96144959
135Cerebral aneurysm (HP:0004944)1.93228661
136Blue sclerae (HP:0000592)1.92218260
137Microvesicular hepatic steatosis (HP:0001414)1.91618499
138Double outlet right ventricle (HP:0001719)1.91220422
139Congenital malformation of the right heart (HP:0011723)1.91220422
140Renal cortical cysts (HP:0000803)1.90808465
141Muscle stiffness (HP:0003552)1.90617444
142Genu recurvatum (HP:0002816)1.89855146
143Chromsome breakage (HP:0040012)1.89800738
144EMG: neuropathic changes (HP:0003445)1.87589925
145Muscle fiber atrophy (HP:0100295)1.87094300
146Hypoplasia of the iris (HP:0007676)1.86908616
147Aplasia of the musculature (HP:0100854)1.86651971
148Generalized aminoaciduria (HP:0002909)1.85469199
149Hyperextensible skin (HP:0000974)1.85393987
150Ragged-red muscle fibers (HP:0003200)1.84535295
151Infantile muscular hypotonia (HP:0008947)1.84498751
152Abnormal delivery (HP:0001787)1.83970390
153Aortic regurgitation (HP:0001659)1.83896084
154Weak cry (HP:0001612)1.83143404
155Renal Fanconi syndrome (HP:0001994)1.82739601
156Patent foramen ovale (HP:0001655)1.82333369
157Type I transferrin isoform profile (HP:0003642)1.82082458
158Optic disc pallor (HP:0000543)1.81946475
159Gowers sign (HP:0003391)1.81009941
160Bell-shaped thorax (HP:0001591)1.79459991
161Disproportionate tall stature (HP:0001519)1.78710649
162Limb-girdle muscle atrophy (HP:0003797)1.76400544
163Generalized muscle weakness (HP:0003324)1.74396319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.62204344
2OBSCN4.56195022
3ZAK4.43831996
4TTN3.31172078
5PLK43.21747808
6MYLK2.96525916
7IRAK42.74536797
8PDGFRA2.63432003
9PINK12.51537063
10MUSK2.44701036
11DDR22.40484625
12EIF2AK32.40042959
13PHKG12.39491946
14PHKG22.39491946
15STK162.38841998
16STK242.14262265
17BUB11.98374552
18LMTK21.94440466
19LATS11.93775102
20LIMK11.85439575
21NEK11.78050455
22PDK31.75895167
23PDK41.75895167
24GRK71.72828441
25BCKDK1.66539431
26AKT31.65112722
27LATS21.54691589
28TIE11.52304141
29WEE11.50577529
30STK38L1.45667380
31DMPK1.44455845
32SRPK11.40149619
33EIF2AK11.39718042
34IRAK11.38147506
35PAK21.37385437
36STK41.36490106
37EIF2AK21.33045882
38PIK3CA1.30767020
39IRAK21.23991924
40PTK21.23653325
41NME21.23533345
42STK381.21717418
43CDC42BPA1.16463723
44PDK21.13649052
45MAP3K71.13497143
46KDR1.09598874
47NME11.06231317
48TTK1.06088690
49CAMK2D1.04758261
50NTRK10.95914637
51MAPKAPK30.95582202
52MET0.92566217
53VRK10.90346075
54EPHB20.89889618
55MAP2K30.87058386
56FLT30.86003218
57MARK10.84075746
58PDGFRB0.83532250
59TESK10.83162586
60MOS0.82372296
61RIPK10.81670844
62BRSK20.80293771
63MKNK20.78682030
64TNIK0.78544165
65TRIB30.78475283
66PAK30.77821042
67ROCK20.77535049
68FGFR10.76053240
69WNK10.74177408
70TEC0.68658957
71NEK90.68654579
72PKN20.66715874
73MAP3K50.65507853
74NLK0.65294057
75PRKD20.64665120
76MAP3K100.64485042
77PLK10.64345578
78ATR0.62500353
79RET0.62245147
80TXK0.60016453
81ILK0.59732285
82MTOR0.56974072
83MAP3K30.56350854
84PIM20.54197395
85ICK0.53185710
86PAK60.53177767
87TRPM70.53163608
88AURKB0.51617285
89MELK0.51182023
90CAMK2A0.51162482
91ACVR1B0.50829406
92ADRBK10.50712488
93IKBKB0.50247747
94RPS6KC10.49994153
95RPS6KL10.49994153
96MAP3K60.48651694
97ROCK10.47643081
98MAP2K10.47588510
99MKNK10.46855736
100RPS6KA60.46614260
101EPHA20.44719829
102ABL20.43148878
103SCYL20.42406475
104PRKD10.42358699
105PTK2B0.41568765
106KIT0.40666013
107DYRK30.40327813
108ERBB40.40143694
109TAOK20.40129961
110STK30.39756370
111ERBB30.39302781
112TSSK60.38240913
113TYK20.38208153
114CDC70.38131043
115MAP3K120.37689175
116CAMK40.37238650
117MAPK120.37088116
118PLK30.36066909
119RPS6KB20.35013210
120PKN10.35003507
121PAK40.34567142
122MAPK70.34035555
123PLK20.33931752
124MAP2K60.33902798
125MAPK40.33732904
126RPS6KA20.33322407
127PRKG10.32946956
128INSRR0.32317137
129PIK3CG0.32160681
130CAMK2B0.31230971
131MAP3K140.30686395
132CAMK2G0.30603701
133CCNB10.30152531
134CAMK10.29590492
135EPHA30.29233264
136BTK0.28834635
137CSNK2A10.28027887
138MAP4K10.27906649
139PRKAA20.27671245
140FGFR40.27176612
141PRKCE0.25788992
142PRKAA10.24973484
143FER0.24838701
144JAK30.24104504
145TGFBR20.24064227
146BRSK10.23870979
147RPS6KA50.23472481
148DAPK30.23135240
149GSK3A0.22266827
150EPHB10.21819555
151BCR0.21074887
152DYRK1B0.20771828
153JAK10.20382281
154SIK10.19465321
155RAF10.17245345
156PRKD30.16987675
157FGFR30.16925281

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.06635384
2Cardiac muscle contraction_Homo sapiens_hsa042603.66122589
3Parkinsons disease_Homo sapiens_hsa050123.60534173
4Oxidative phosphorylation_Homo sapiens_hsa001903.58687171
5ECM-receptor interaction_Homo sapiens_hsa045123.18248214
6DNA replication_Homo sapiens_hsa030303.09351329
7Proteasome_Homo sapiens_hsa030502.94215427
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.90236493
9Focal adhesion_Homo sapiens_hsa045102.73919681
10Dilated cardiomyopathy_Homo sapiens_hsa054142.71813864
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66156151
12RNA polymerase_Homo sapiens_hsa030202.65816880
13Huntingtons disease_Homo sapiens_hsa050162.62654805
14Ribosome_Homo sapiens_hsa030102.42421614
15Alzheimers disease_Homo sapiens_hsa050102.41324254
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31070882
17Mismatch repair_Homo sapiens_hsa034302.30721441
18Homologous recombination_Homo sapiens_hsa034402.12448165
19Protein digestion and absorption_Homo sapiens_hsa049742.06834002
20Adherens junction_Homo sapiens_hsa045201.95390621
21Fanconi anemia pathway_Homo sapiens_hsa034601.91610434
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91549916
23Pyrimidine metabolism_Homo sapiens_hsa002401.91167714
24Base excision repair_Homo sapiens_hsa034101.73795396
25Propanoate metabolism_Homo sapiens_hsa006401.70151560
26Carbon metabolism_Homo sapiens_hsa012001.66514738
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65283784
28Amoebiasis_Homo sapiens_hsa051461.64293134
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.56075248
30Proteoglycans in cancer_Homo sapiens_hsa052051.50589503
31TGF-beta signaling pathway_Homo sapiens_hsa043501.49911350
32Regulation of actin cytoskeleton_Homo sapiens_hsa048101.48934537
33Tight junction_Homo sapiens_hsa045301.48781848
34Viral myocarditis_Homo sapiens_hsa054161.47004898
35Spliceosome_Homo sapiens_hsa030401.46985391
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45167943
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43659557
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.42126070
39Nucleotide excision repair_Homo sapiens_hsa034201.40031368
40RNA degradation_Homo sapiens_hsa030181.38834058
41Hippo signaling pathway_Homo sapiens_hsa043901.38667435
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37211729
43Purine metabolism_Homo sapiens_hsa002301.36643960
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31774328
45Small cell lung cancer_Homo sapiens_hsa052221.29185711
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.25518166
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24952149
48Fatty acid degradation_Homo sapiens_hsa000711.20620853
49Central carbon metabolism in cancer_Homo sapiens_hsa052301.17736688
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16524767
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12784102
52Basal transcription factors_Homo sapiens_hsa030221.12464060
53Hedgehog signaling pathway_Homo sapiens_hsa043401.12165058
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11116226
55Oxytocin signaling pathway_Homo sapiens_hsa049211.10243168
56RNA transport_Homo sapiens_hsa030131.06452845
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01769138
58Melanoma_Homo sapiens_hsa052181.01083965
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.99367905
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99285399
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95273185
62Basal cell carcinoma_Homo sapiens_hsa052170.94146584
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93576787
64cAMP signaling pathway_Homo sapiens_hsa040240.87014838
65Cell cycle_Homo sapiens_hsa041100.85680856
66Gap junction_Homo sapiens_hsa045400.85277843
67One carbon pool by folate_Homo sapiens_hsa006700.85001500
68Non-homologous end-joining_Homo sapiens_hsa034500.83455283
69Renin secretion_Homo sapiens_hsa049240.83180287
70Galactose metabolism_Homo sapiens_hsa000520.80085592
71p53 signaling pathway_Homo sapiens_hsa041150.80022350
72Pathways in cancer_Homo sapiens_hsa052000.75429954
73MicroRNAs in cancer_Homo sapiens_hsa052060.75267509
74Melanogenesis_Homo sapiens_hsa049160.74277379
75Epstein-Barr virus infection_Homo sapiens_hsa051690.73817823
76Endometrial cancer_Homo sapiens_hsa052130.73257892
77Biosynthesis of amino acids_Homo sapiens_hsa012300.71971228
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69499099
79Axon guidance_Homo sapiens_hsa043600.68068101
80Starch and sucrose metabolism_Homo sapiens_hsa005000.67659012
81Platelet activation_Homo sapiens_hsa046110.67526713
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67449042
83Protein export_Homo sapiens_hsa030600.67031946
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66829832
85Fatty acid elongation_Homo sapiens_hsa000620.66443753
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.64764105
87Herpes simplex infection_Homo sapiens_hsa051680.64716024
88Fatty acid metabolism_Homo sapiens_hsa012120.61083097
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59109247
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58599205
91HIF-1 signaling pathway_Homo sapiens_hsa040660.57898764
92AMPK signaling pathway_Homo sapiens_hsa041520.56451976
93Pentose phosphate pathway_Homo sapiens_hsa000300.55995052
94Gastric acid secretion_Homo sapiens_hsa049710.55882199
95Graft-versus-host disease_Homo sapiens_hsa053320.54937327
96Lysine degradation_Homo sapiens_hsa003100.54929715
97Metabolic pathways_Homo sapiens_hsa011000.54766157
98Renal cell carcinoma_Homo sapiens_hsa052110.54664532
99Insulin secretion_Homo sapiens_hsa049110.54616794
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.53964535
101Arachidonic acid metabolism_Homo sapiens_hsa005900.53870988
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52957821
103Rap1 signaling pathway_Homo sapiens_hsa040150.51785838
104Fructose and mannose metabolism_Homo sapiens_hsa000510.51329638
105Wnt signaling pathway_Homo sapiens_hsa043100.51320666
106Measles_Homo sapiens_hsa051620.50960311
107Bladder cancer_Homo sapiens_hsa052190.50245629
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49827292
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49612687
110Pyruvate metabolism_Homo sapiens_hsa006200.48894181
111beta-Alanine metabolism_Homo sapiens_hsa004100.48763141
112Glioma_Homo sapiens_hsa052140.48608796
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48259857
114Malaria_Homo sapiens_hsa051440.48169337
115Allograft rejection_Homo sapiens_hsa053300.48008191
116Thyroid hormone synthesis_Homo sapiens_hsa049180.47309672
117Primary immunodeficiency_Homo sapiens_hsa053400.47156477
118GnRH signaling pathway_Homo sapiens_hsa049120.45959566
119Leishmaniasis_Homo sapiens_hsa051400.45653573
120Other glycan degradation_Homo sapiens_hsa005110.45419162
121Regulation of autophagy_Homo sapiens_hsa041400.44724940
122Arginine and proline metabolism_Homo sapiens_hsa003300.44484744
123Pancreatic cancer_Homo sapiens_hsa052120.44470374
124MAPK signaling pathway_Homo sapiens_hsa040100.43658060
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43648416
126PPAR signaling pathway_Homo sapiens_hsa033200.43371949
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.42530007
128Pancreatic secretion_Homo sapiens_hsa049720.42486193
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.41946712
130Chronic myeloid leukemia_Homo sapiens_hsa052200.41864992
131Cholinergic synapse_Homo sapiens_hsa047250.41827313
132Circadian entrainment_Homo sapiens_hsa047130.41543395
133Glutathione metabolism_Homo sapiens_hsa004800.40878809
134Legionellosis_Homo sapiens_hsa051340.40772563
135Circadian rhythm_Homo sapiens_hsa047100.40448165
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40290215
137Prostate cancer_Homo sapiens_hsa052150.40280079
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39863560
139Complement and coagulation cascades_Homo sapiens_hsa046100.39728112
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.38138329
141mTOR signaling pathway_Homo sapiens_hsa041500.36458519
142FoxO signaling pathway_Homo sapiens_hsa040680.36381833
143Choline metabolism in cancer_Homo sapiens_hsa052310.33141610
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32776757
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31194904
146Calcium signaling pathway_Homo sapiens_hsa040200.31031433
147Prion diseases_Homo sapiens_hsa050200.30368814
148mRNA surveillance pathway_Homo sapiens_hsa030150.29556033
149Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29144595
150Influenza A_Homo sapiens_hsa051640.26516104
151Salivary secretion_Homo sapiens_hsa049700.25592134
152Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25439521
153Dorso-ventral axis formation_Homo sapiens_hsa043200.25421070
154Phenylalanine metabolism_Homo sapiens_hsa003600.25117218
155HTLV-I infection_Homo sapiens_hsa051660.24288460
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.24279696
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23529499
158cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21026210
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.19803330
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19333757
161SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19096689
162Asthma_Homo sapiens_hsa053100.19082304
163Glucagon signaling pathway_Homo sapiens_hsa049220.18891624
164Toxoplasmosis_Homo sapiens_hsa051450.18155729
165Hematopoietic cell lineage_Homo sapiens_hsa046400.18065220
166Insulin resistance_Homo sapiens_hsa049310.16315031
167Apoptosis_Homo sapiens_hsa042100.14700854
168Autoimmune thyroid disease_Homo sapiens_hsa053200.13057500
169Insulin signaling pathway_Homo sapiens_hsa049100.11423615
170Systemic lupus erythematosus_Homo sapiens_hsa053220.10271504
171Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10263089

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