ALOX15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)9.88358131
2axoneme assembly (GO:0035082)8.32538298
3citrulline biosynthetic process (GO:0019240)7.90120316
4germinal center formation (GO:0002467)7.61662692
5left/right pattern formation (GO:0060972)7.47261610
6opsonization (GO:0008228)7.45831043
7endothelial cell chemotaxis (GO:0035767)7.42951313
8* regulation of apoptotic cell clearance (GO:2000425)7.41167492
9production of molecular mediator involved in inflammatory response (GO:0002532)7.06019298
10regulation of cilium movement (GO:0003352)6.95339357
11primary alcohol catabolic process (GO:0034310)6.59669233
12complement activation (GO:0006956)6.49701701
13cellular extravasation (GO:0045123)6.49401468
14regulation of T cell chemotaxis (GO:0010819)6.35635181
15positive regulation of T cell chemotaxis (GO:0010820)6.35635181
16regulation of endothelial cell chemotaxis (GO:2001026)6.26966073
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.26020979
18negative regulation of cell killing (GO:0031342)6.26020979
19detection of molecule of bacterial origin (GO:0032490)6.08714169
20left/right axis specification (GO:0070986)6.02808965
21regulation of complement activation (GO:0030449)5.87937580
22positive regulation of Rap GTPase activity (GO:0032854)5.78315929
23ethanol metabolic process (GO:0006067)5.72326452
24positive regulation of cell adhesion mediated by integrin (GO:0033630)5.66372305
25diterpenoid biosynthetic process (GO:0016102)5.60066600
26negative regulation of granulocyte differentiation (GO:0030853)5.53677408
27activated T cell proliferation (GO:0050798)5.49333695
28ventricular system development (GO:0021591)5.47403366
29vitamin transmembrane transport (GO:0035461)5.47087173
30regulation of humoral immune response (GO:0002920)5.44961757
31response to xenobiotic stimulus (GO:0009410)5.39506997
32regulation of protein activation cascade (GO:2000257)5.35687030
33regulation of macrophage chemotaxis (GO:0010758)5.33251351
34leukocyte migration involved in inflammatory response (GO:0002523)5.23518756
35negative regulation of B cell mediated immunity (GO:0002713)5.17619672
36negative regulation of immunoglobulin mediated immune response (GO:0002890)5.17619672
37tolerance induction (GO:0002507)5.16394063
38microtubule bundle formation (GO:0001578)5.13212901
39citrulline metabolic process (GO:0000052)5.02122300
40regulation of T cell migration (GO:2000404)5.02110761
41regulation of Rap GTPase activity (GO:0032317)4.95241101
42* lipoxygenase pathway (GO:0019372)4.85454240
43pyrimidine-containing compound transmembrane transport (GO:0072531)4.84034488
44chronic inflammatory response (GO:0002544)4.78095678
45regulation of germinal center formation (GO:0002634)4.77338389
46intraciliary transport (GO:0042073)4.72302222
47one-carbon compound transport (GO:0019755)4.69663112
48negative regulation of interleukin-12 production (GO:0032695)4.66165670
49cilium organization (GO:0044782)4.61884792
50complement activation, classical pathway (GO:0006958)4.61550788
51negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.60625439
52leukocyte tethering or rolling (GO:0050901)4.56031608
53glomerular epithelial cell development (GO:0072310)4.54357002
54protein activation cascade (GO:0072376)4.49717416
55cilium assembly (GO:0042384)4.47403597
56cyclooxygenase pathway (GO:0019371)4.44718855
57negative regulation of humoral immune response (GO:0002921)4.41028778
58regulation of dendritic cell antigen processing and presentation (GO:0002604)4.32927585
59ethanol oxidation (GO:0006069)4.31669642
60regulation of interleukin-5 production (GO:0032674)4.31003547
61cytokine production involved in immune response (GO:0002367)4.18514058
62peptidyl-arginine modification (GO:0018195)4.12137140
63regulation of interleukin-13 production (GO:0032656)4.08798987
64leukotriene biosynthetic process (GO:0019370)4.07751609
65detection of external biotic stimulus (GO:0098581)4.07085660
66iron ion import (GO:0097286)3.99967560
67positive regulation of tolerance induction (GO:0002645)3.98941022
68virion attachment to host cell (GO:0019062)3.92928632
69adhesion of symbiont to host cell (GO:0044650)3.92928632
70regulation of lymphocyte migration (GO:2000401)3.89299917
71regulation of microtubule-based movement (GO:0060632)3.88518416
72sperm capacitation (GO:0048240)3.85290654
73centriole assembly (GO:0098534)3.84200992
74positive regulation of T cell migration (GO:2000406)3.81626805
75microtubule-based movement (GO:0007018)3.79169861
76* regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.78082570
77respiratory burst (GO:0045730)3.77361595
78negative regulation of interleukin-6 production (GO:0032715)3.76456115
79* apoptotic cell clearance (GO:0043277)3.76416139
80prostaglandin biosynthetic process (GO:0001516)3.76122043
81prostanoid biosynthetic process (GO:0046457)3.76122043
82lung epithelium development (GO:0060428)3.73437326
83regulation of tolerance induction (GO:0002643)3.73144232
84lymphocyte chemotaxis (GO:0048247)3.73079280
85leukocyte cell-cell adhesion (GO:0007159)3.72275551
86production of molecular mediator of immune response (GO:0002440)3.69352322
87regulation of B cell receptor signaling pathway (GO:0050855)3.68942198
88peptidyl-glutamic acid carboxylation (GO:0017187)3.67942682
89protein carboxylation (GO:0018214)3.67942682
90regulation of lymphocyte chemotaxis (GO:1901623)3.67256479
91protein localization to cilium (GO:0061512)3.64909150
92positive regulation of antigen processing and presentation (GO:0002579)3.64136979
93negative regulation of T cell differentiation in thymus (GO:0033085)3.63870001
94retinoic acid metabolic process (GO:0042573)3.63843133
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.63445213
96regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63321262
97establishment of apical/basal cell polarity (GO:0035089)3.57420125
98positive regulation of phagocytosis (GO:0050766)3.55455481
99terpenoid biosynthetic process (GO:0016114)3.54651906
100cytoskeletal anchoring at plasma membrane (GO:0007016)3.51852882
101lymph node development (GO:0048535)3.49951330
102cellular component assembly involved in morphogenesis (GO:0010927)3.49451187
103regulation of interleukin-6 biosynthetic process (GO:0045408)3.47960770
104* icosanoid biosynthetic process (GO:0046456)3.46990264
105* fatty acid derivative biosynthetic process (GO:1901570)3.46990264
106cell projection assembly (GO:0030031)3.44131256
107* leukotriene metabolic process (GO:0006691)3.43997987
108polyol transport (GO:0015791)3.41544114
109negative regulation of macrophage differentiation (GO:0045650)3.37827976
110detection of biotic stimulus (GO:0009595)3.35702423
111regulation of mononuclear cell migration (GO:0071675)3.34205722
112negative regulation of interleukin-2 production (GO:0032703)3.33546500
113cilium morphogenesis (GO:0060271)3.31224062
114cGMP-mediated signaling (GO:0019934)3.30968994
115adaptation of signaling pathway (GO:0023058)3.30698782
116adhesion of symbiont to host (GO:0044406)3.27959482
117positive regulation of blood coagulation (GO:0030194)3.26517684
118positive regulation of hemostasis (GO:1900048)3.26517684
119lateral ventricle development (GO:0021670)3.25613054
120regulation of antigen processing and presentation (GO:0002577)3.23498695
121negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.22399243
122cytoplasmic microtubule organization (GO:0031122)3.21608922
123* regulation of phagocytosis (GO:0050764)3.19810634
124cellular response to interleukin-6 (GO:0071354)3.15654629
125negative regulation of bone mineralization (GO:0030502)3.15310217
126sequestering of extracellular ligand from receptor (GO:0035581)3.14323636
127positive regulation of coagulation (GO:0050820)3.12193321
128regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.11395268
129positive regulation of lymphocyte migration (GO:2000403)3.11267914
130negative regulation of inclusion body assembly (GO:0090084)3.09265530
131O-glycan processing (GO:0016266)3.03842652
132oxygen transport (GO:0015671)3.03715807
133cardiac epithelial to mesenchymal transition (GO:0060317)3.01778539
134negative regulation of erythrocyte differentiation (GO:0045647)2.98707541
135establishment of monopolar cell polarity (GO:0061162)2.98551681
136establishment or maintenance of monopolar cell polarity (GO:0061339)2.98551681
137response to methylmercury (GO:0051597)2.95633016
138hypotonic response (GO:0006971)2.94828300
139prostanoid metabolic process (GO:0006692)2.94046632
140prostaglandin metabolic process (GO:0006693)2.94046632
141primary alcohol metabolic process (GO:0034308)2.89855309
142T cell mediated immunity (GO:0002456)2.89388841
143retinol metabolic process (GO:0042572)2.89218982
144positive regulation of smoothened signaling pathway (GO:0045880)2.88562516
145import into cell (GO:0098657)2.86439098
146adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.83378022
147defense response to Gram-negative bacterium (GO:0050829)2.81935739
148regulation of cell adhesion mediated by integrin (GO:0033628)2.81780012
149antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80969675
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80969675
151* unsaturated fatty acid biosynthetic process (GO:0006636)2.80823401
152negative regulation of lymphocyte mediated immunity (GO:0002707)2.79051629
153regulation of interleukin-4 production (GO:0032673)2.77409335
154modulation by symbiont of host immune response (GO:0052553)2.76988896
155positive regulation by symbiont of host defense response (GO:0052509)2.76988896
156modulation by symbiont of host defense response (GO:0052031)2.76988896
157modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.76988896
158positive regulation by organism of defense response of other organism involved in symbiotic interact2.76988896
159nucleoside diphosphate phosphorylation (GO:0006165)2.73279039
160hydrogen peroxide biosynthetic process (GO:0050665)2.71634759
161multicellular organismal water homeostasis (GO:0050891)2.71223584
162histone H3-K36 demethylation (GO:0070544)2.69892456
163dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68033999
164phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.65802288
165regulation of autophagic vacuole assembly (GO:2000785)2.62277628
166positive regulation of cellular amide metabolic process (GO:0034250)2.62197107
167CDP-diacylglycerol biosynthetic process (GO:0016024)2.61271991
168exogenous drug catabolic process (GO:0042738)2.55488208
169amyloid precursor protein catabolic process (GO:0042987)2.51808217
170establishment of planar polarity (GO:0001736)2.50012191
171establishment of tissue polarity (GO:0007164)2.50012191
172negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.48567828
173reactive oxygen species biosynthetic process (GO:1903409)2.39001776
174filopodium assembly (GO:0046847)2.37630058
175regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.37010735
176microtubule depolymerization (GO:0007019)2.35963351
177glutathione derivative metabolic process (GO:1901685)2.35234111
178glutathione derivative biosynthetic process (GO:1901687)2.35234111
179negative regulation of type 2 immune response (GO:0002829)2.33927644
180microtubule polymerization or depolymerization (GO:0031109)2.33418792
181water homeostasis (GO:0030104)2.32498185
182regulation of vacuole organization (GO:0044088)2.32486421
183epithelial cell differentiation involved in prostate gland development (GO:0060742)2.32148656
184CDP-diacylglycerol metabolic process (GO:0046341)2.32122662
185regulation of microtubule depolymerization (GO:0031114)2.29208129
186* negative regulation of adaptive immune response (GO:0002820)2.28895849
187regulation of T-helper 2 cell differentiation (GO:0045628)2.27862852
188regulation of response to osmotic stress (GO:0047484)2.25172469
189progesterone metabolic process (GO:0042448)2.23744550
190axonemal dynein complex assembly (GO:0070286)18.6940665
191cilium or flagellum-dependent cell motility (GO:0001539)16.1502069
192cilium movement (GO:0003341)13.5203057
193motile cilium assembly (GO:0044458)12.4954033
194epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.3373172
195regulation of integrin activation (GO:0033623)12.2927579
196epithelial cilium movement (GO:0003351)11.1866857
197complement activation, alternative pathway (GO:0006957)10.6074335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.73788359
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.62623794
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.29062412
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.41600115
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.29809623
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27973489
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94330131
8DROSHA_22980978_ChIP-Seq_HELA_Human2.89450374
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80993174
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78311587
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74634821
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.60841676
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55056601
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53963914
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43371639
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38966548
17AHR_22903824_ChIP-Seq_MCF-7_Human2.29416898
18SCL_19346495_ChIP-Seq_HPC-7_Human2.17255295
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16452374
20SPI1_23127762_ChIP-Seq_K562_Human2.13495714
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.12685289
22LXR_22292898_ChIP-Seq_THP-1_Human2.10139857
23VDR_21846776_ChIP-Seq_THP-1_Human2.07355939
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.02413249
25BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02137027
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.96724359
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.95782865
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95752997
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91419076
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89858751
31TCF7_22412390_ChIP-Seq_EML_Mouse1.87784197
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87431847
33VDR_24763502_ChIP-Seq_THP-1_Human1.87274832
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86010176
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83469173
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.80418668
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.71970746
38ELK3_25401928_ChIP-Seq_HUVEC_Human1.71925295
39MYC_22102868_ChIP-Seq_BL_Human1.71147458
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70319360
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69293786
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68659889
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67201261
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.66727102
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.65788219
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65145777
47SPI1_23547873_ChIP-Seq_NB4_Human1.63083159
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61831790
49SMC4_20622854_ChIP-Seq_HELA_Human1.60682270
50RXR_22158963_ChIP-Seq_LIVER_Mouse1.59943835
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.59610240
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58608757
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.58420042
54TP63_23658742_ChIP-Seq_EP156T_Human1.56269573
55FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52266491
56GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51732081
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51509799
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.48270601
59KDM2B_26808549_Chip-Seq_DND41_Human1.47675207
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46537421
61ESR1_21235772_ChIP-Seq_MCF-7_Human1.45805702
62RUNX_20019798_ChIP-Seq_JUKART_Human1.43913417
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42502873
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.41271151
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.40965216
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40912893
67TRIM28_21343339_ChIP-Seq_HEK293_Human1.40639623
68STAT1_20625510_ChIP-Seq_HELA_Human1.40267206
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38191760
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.37804607
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37767474
72SPI1_20517297_ChIP-Seq_HL60_Human1.35210181
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35204427
74RAD21_21589869_ChIP-Seq_MESCs_Mouse1.35098086
75VDR_24787735_ChIP-Seq_THP-1_Human1.34479523
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34163201
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31267539
78GATA2_19941826_ChIP-Seq_K562_Human1.30988278
79TP63_22573176_ChIP-Seq_HFKS_Human1.29579404
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29102334
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28648050
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27584182
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26031907
84MAF_26560356_Chip-Seq_TH1_Human1.25082971
85SOX2_20726797_ChIP-Seq_SW620_Human1.24220026
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23859554
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.23620231
88* SMRT_27268052_Chip-Seq_Bcells_Human1.22648601
89GATA1_19941826_ChIP-Seq_K562_Human1.22577794
90KLF5_25053715_ChIP-Seq_YYC3_Human1.21379446
91* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20421115
92TP53_16413492_ChIP-PET_HCT116_Human1.19477034
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.19208403
94* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18516453
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17922914
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16109548
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15533165
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15128737
99MYB_26560356_Chip-Seq_TH2_Human1.13952048
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.13951384
101FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13555726
102FOXA1_25552417_ChIP-Seq_VCAP_Human1.13261122
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12818886
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12567421
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12468576
106CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11068133
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11061297
108SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10406470
109LXR_22158963_ChIP-Seq_LIVER_Mouse1.10397448
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10346933
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10332604
112GATA3_27048872_Chip-Seq_THYMUS_Human1.08982969
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.08508718
114CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08448803
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08293345
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07515847
117UTX_26944678_Chip-Seq_JUKART_Human1.07435172
118PU_27001747_Chip-Seq_BMDM_Mouse1.06840066
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05400264
120TP53_22127205_ChIP-Seq_IMR90_Human1.04399617
121PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04225065
122FOXA2_19822575_ChIP-Seq_HepG2_Human1.04114921
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03978891
124EGR1_19032775_ChIP-ChIP_M12_Human1.02716745
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.01266968
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01172930
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01108710
128NCOR1_26117541_ChIP-Seq_K562_Human1.00868580
129ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00096397
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99823229
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99349776
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98924769
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98437737
134FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.97367572
135SMAD3_21741376_ChIP-Seq_HESCs_Human0.96908216
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96088330
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95972947
138VDR_22108803_ChIP-Seq_LS180_Human0.95655889
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95539278
140CDX2_20551321_ChIP-Seq_CACO-2_Human0.95390546
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93804567
142KDM2B_26808549_Chip-Seq_K562_Human0.93453781
143CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93317180
144ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93190425
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.92726939
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.92726939
147NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91759153
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91338655
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90797069
150ERG_21242973_ChIP-ChIP_JURKAT_Human0.90369486
151TP63_17297297_ChIP-ChIP_HaCaT_Human0.90239857
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.87726255
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83773154
154GATA4_25053715_ChIP-Seq_YYC3_Human0.83606694
155CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82610056
156TP53_18474530_ChIP-ChIP_U2OS_Human0.82562160
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82078378
158* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81692708
159GATA6_21074721_ChIP-Seq_CACO-2_Human0.81465816
160GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.79929858

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.02475493
2MP0002132_abnormal_respiratory_system4.64217885
3MP0002653_abnormal_ependyma_morphology4.62764541
4MP0005058_abnormal_lysosome_morphology4.49856227
5MP0003436_decreased_susceptibility_to4.09405111
6MP0003724_increased_susceptibility_to3.65038120
7MP0005671_abnormal_response_to3.55386455
8MP0009840_abnormal_foam_cell3.35340176
9MP0003705_abnormal_hypodermis_morpholog3.25460248
10MP0000685_abnormal_immune_system3.19927996
11MP0003075_altered_response_to3.16542181
12MP0002277_abnormal_respiratory_mucosa3.14041863
13MP0001533_abnormal_skeleton_physiology2.89017392
14MP0008438_abnormal_cutaneous_collagen2.85356894
15MP0005025_abnormal_response_to2.83818806
16MP0002419_abnormal_innate_immunity2.80876258
17MP0003303_peritoneal_inflammation2.67822279
18MP0004133_heterotaxia2.66624173
19MP0009333_abnormal_splenocyte_physiolog2.64223792
20* MP0001790_abnormal_immune_system2.53495261
21* MP0005387_immune_system_phenotype2.53495261
22MP0004043_abnormal_pH_regulation2.48950529
23MP0005000_abnormal_immune_tolerance2.47236124
24MP0001851_eye_inflammation2.45310734
25MP0002148_abnormal_hypersensitivity_rea2.44619172
26MP0001984_abnormal_olfaction2.36442374
27MP0002138_abnormal_hepatobiliary_system2.33744738
28MP0008789_abnormal_olfactory_epithelium2.32068942
29MP0001849_ear_inflammation2.29722999
30MP0008004_abnormal_stomach_pH2.25161597
31MP0005464_abnormal_platelet_physiology2.22499245
32MP0010234_abnormal_vibrissa_follicle2.21611186
33MP0004510_myositis2.15129677
34MP0003878_abnormal_ear_physiology2.14032116
35MP0005377_hearing/vestibular/ear_phenot2.14032116
36MP0009780_abnormal_chondrocyte_physiolo2.06531505
37MP0001800_abnormal_humoral_immune2.02624817
38MP0001958_emphysema2.01805050
39MP0002452_abnormal_antigen_presenting1.96018000
40MP0005623_abnormal_meninges_morphology1.91818108
41MP0004885_abnormal_endolymph1.91393227
42MP0003566_abnormal_cell_adhesion1.84426810
43MP0003172_abnormal_lysosome_physiology1.83525419
44MP0002420_abnormal_adaptive_immunity1.69679196
45MP0002166_altered_tumor_susceptibility1.68439553
46MP0000604_amyloidosis1.66904674
47MP0001819_abnormal_immune_cell1.66519038
48MP0005394_taste/olfaction_phenotype1.65996370
49MP0005499_abnormal_olfactory_system1.65996370
50MP0004264_abnormal_extraembryonic_tissu1.61799644
51MP0002405_respiratory_system_inflammati1.60515591
52MP0003279_aneurysm1.59919983
53MP0001835_abnormal_antigen_presentation1.57737841
54MP0001845_abnormal_inflammatory_respons1.57489603
55MP0005248_abnormal_Harderian_gland1.54762920
56MP0005390_skeleton_phenotype1.54354049
57MP0002933_joint_inflammation1.52798229
58MP0000465_gastrointestinal_hemorrhage1.51205546
59MP0000678_abnormal_parathyroid_gland1.50389630
60MP0010678_abnormal_skin_adnexa1.47797552
61MP0005023_abnormal_wound_healing1.47703421
62MP0001765_abnormal_ion_homeostasis1.47486797
63MP0002723_abnormal_immune_serum1.43943497
64MP0004019_abnormal_vitamin_homeostasis1.43895428
65MP0000767_abnormal_smooth_muscle1.40419329
66MP0001915_intracranial_hemorrhage1.37325556
67* MP0004947_skin_inflammation1.35922294
68MP0005647_abnormal_sex_gland1.35879203
69MP0003690_abnormal_glial_cell1.32305686
70MP0009785_altered_susceptibility_to1.32028593
71MP0005166_decreased_susceptibility_to1.31751690
72MP0003300_gastrointestinal_ulcer1.29610148
73MP0002909_abnormal_adrenal_gland1.26814322
74* MP0000716_abnormal_immune_system1.26475532
75MP0000383_abnormal_hair_follicle1.25329191
76MP0009763_increased_sensitivity_to1.24237574
77MP0002396_abnormal_hematopoietic_system1.23212635
78MP0001727_abnormal_embryo_implantation1.20542129
79MP0002736_abnormal_nociception_after1.20509242
80MP0005408_hypopigmentation1.18696874
81MP0003638_abnormal_response/metabolism_1.17802307
82MP0002133_abnormal_respiratory_system1.16651222
83MP0005388_respiratory_system_phenotype1.16651222
84* MP0000689_abnormal_spleen_morphology1.14417112
85MP0006082_CNS_inflammation1.13048632
86MP0004272_abnormal_basement_membrane1.12374494
87MP0003183_abnormal_peptide_metabolism1.12057196
88MP0003828_pulmonary_edema1.10956684
89MP0003656_abnormal_erythrocyte_physiolo1.10075999
90MP0009278_abnormal_bone_marrow1.08881386
91MP0001853_heart_inflammation1.04615815
92MP0002254_reproductive_system_inflammat1.02109923
93MP0003191_abnormal_cellular_cholesterol1.01774341
94MP0002168_other_aberrant_phenotype1.01333294
95MP0003453_abnormal_keratinocyte_physiol0.99066896
96MP0002006_tumorigenesis0.98700176
97MP0005395_other_phenotype0.98597802
98MP0003866_abnormal_defecation0.98562023
99* MP0002429_abnormal_blood_cell0.98386675
100MP0008469_abnormal_protein_level0.97761698
101MP0003448_altered_tumor_morphology0.97129747
102MP0005164_abnormal_response_to0.97013754
103MP0005310_abnormal_salivary_gland0.96747150
104MP0000858_altered_metastatic_potential0.96482273
105MP0009053_abnormal_anal_canal0.95901004
106MP0004782_abnormal_surfactant_physiolog0.95814067
107MP0002136_abnormal_kidney_physiology0.94452479
108MP0003252_abnormal_bile_duct0.93789897
109MP0005076_abnormal_cell_differentiation0.92447648
110* MP0002398_abnormal_bone_marrow0.91589520
111MP0005409_darkened_coat_color0.91474841
112MP0000343_altered_response_to0.91319075
113* MP0002722_abnormal_immune_system0.91042703
114MP0002282_abnormal_trachea_morphology0.90726632
115* MP0000249_abnormal_blood_vessel0.89211415
116MP0005083_abnormal_biliary_tract0.88717529
117MP0000566_synostosis0.87985134
118MP0003329_amyloid_beta_deposits0.87080806
119MP0000490_abnormal_crypts_of0.82533796
120MP0003091_abnormal_cell_migration0.80606191
121MP0009765_abnormal_xenobiotic_induced0.80487216
122MP0010352_gastrointestinal_tract_polyps0.80320638
123MP0010155_abnormal_intestine_physiology0.78110405
124MP0004883_abnormal_blood_vessel0.77781428
125MP0002135_abnormal_kidney_morphology0.76077222
126MP0005670_abnormal_white_adipose0.75961775
127MP0001873_stomach_inflammation0.73994401
128MP0005220_abnormal_exocrine_pancreas0.73573319
129MP0002971_abnormal_brown_adipose0.73204197
130MP0005636_abnormal_mineral_homeostasis0.71048349
131MP0005397_hematopoietic_system_phenotyp0.70512247
132MP0001545_abnormal_hematopoietic_system0.70512247
133MP0005165_increased_susceptibility_to0.69843898
134MP0002998_abnormal_bone_remodeling0.69490344
135MP0002249_abnormal_larynx_morphology0.68838475
136* MP0001614_abnormal_blood_vessel0.67895202
137MP0000371_diluted_coat_color0.67839722
138MP0005332_abnormal_amino_acid0.66834320
139MP0001485_abnormal_pinna_reflex0.66361763
140MP0004185_abnormal_adipocyte_glucose0.65963352
141MP0001663_abnormal_digestive_system0.63160821
142MP0003045_fibrosis0.62871509
143MP0009931_abnormal_skin_appearance0.62298460
144MP0010329_abnormal_lipoprotein_level0.62289195
145MP0010368_abnormal_lymphatic_system0.62200143
146MP0000598_abnormal_liver_morphology0.60439970
147MP0003634_abnormal_glial_cell0.56731634
148MP0009643_abnormal_urine_homeostasis0.53145856
149MP0002877_abnormal_melanocyte_morpholog0.53128786
150MP0002128_abnormal_blood_circulation0.51994686

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.82147912
2Glomerulonephritis (HP:0000099)8.23283460
3Chronic bronchitis (HP:0004469)7.42014818
4Abnormality of complement system (HP:0005339)7.30014763
5Bronchiectasis (HP:0002110)7.21862575
6Complement deficiency (HP:0004431)6.77300116
7Dysostosis multiplex (HP:0000943)5.59980146
8Shallow orbits (HP:0000586)5.56887793
9Vacuolated lymphocytes (HP:0001922)5.46453440
10Recurrent gram-negative bacterial infections (HP:0005420)5.06897298
11Nephritis (HP:0000123)4.64291705
12Spondylolisthesis (HP:0003302)4.61230491
13Recurrent sinusitis (HP:0011108)4.52804041
14Urinary glycosaminoglycan excretion (HP:0003541)4.44408528
15Mucopolysacchariduria (HP:0008155)4.44408528
16Cervical subluxation (HP:0003308)4.31055224
17Bronchitis (HP:0012387)4.26376153
18Infertility (HP:0000789)4.22891800
19Male infertility (HP:0003251)4.18880892
20Recurrent abscess formation (HP:0002722)4.16537810
21Abnormality of mucopolysaccharide metabolism (HP:0011020)4.12296735
22Abnormality of polysaccharide metabolism (HP:0011012)4.12296735
23Abnormality of glycosaminoglycan metabolism (HP:0004371)4.12296735
24Asymmetric septal hypertrophy (HP:0001670)4.09838675
25Pustule (HP:0200039)3.97963062
26Recurrent otitis media (HP:0000403)3.97314541
27Chronic sinusitis (HP:0011109)3.96344020
28Wrist flexion contracture (HP:0001239)3.94001855
29Loss of speech (HP:0002371)3.93453502
30Nasal polyposis (HP:0100582)3.90377700
31J-shaped sella turcica (HP:0002680)3.88881335
32Eczematoid dermatitis (HP:0000976)3.67462219
33Bronchomalacia (HP:0002780)3.65673128
34Joint stiffness (HP:0001387)3.55485153
35Arthropathy (HP:0003040)3.43307720
36Peritonitis (HP:0002586)3.41279415
37Abnormality of the nasal mucosa (HP:0000433)3.37601968
38Deep venous thrombosis (HP:0002625)3.30148121
39Chronic otitis media (HP:0000389)3.23033287
40Enlarged penis (HP:0000040)3.16813733
41Polygenic inheritance (HP:0010982)3.09333513
42Menorrhagia (HP:0000132)3.09115569
43Abnormality of the lumbar spine (HP:0100712)3.06720207
44Cerebral aneurysm (HP:0004944)3.06303552
45Hand muscle atrophy (HP:0009130)3.02961004
46Short nail (HP:0001799)3.00764756
47Occipital encephalocele (HP:0002085)2.98298056
48Deformed sella turcica (HP:0002681)2.98112485
49Atelectasis (HP:0100750)2.94574566
50Pancreatic fibrosis (HP:0100732)2.86531214
51Recurrent bacterial skin infections (HP:0005406)2.86193263
52Broad metatarsal (HP:0001783)2.85009308
53Hyperactive renin-angiotensin system (HP:0000841)2.81277447
54Thoracic kyphosis (HP:0002942)2.78443382
55True hermaphroditism (HP:0010459)2.68102217
56Abnormality of macrophages (HP:0004311)2.65779808
57Multifactorial inheritance (HP:0001426)2.65380721
58Turricephaly (HP:0000262)2.63266791
59Prolonged partial thromboplastin time (HP:0003645)2.63007917
60Gastrointestinal infarctions (HP:0005244)2.55239871
61Abnormality of the common coagulation pathway (HP:0010990)2.53797709
62Prolonged bleeding time (HP:0003010)2.49114762
63Periodontitis (HP:0000704)2.48806982
64Beaking of vertebral bodies (HP:0004568)2.48168838
65Gingivitis (HP:0000230)2.43896930
66Broad face (HP:0000283)2.41994904
67Distal upper limb amyotrophy (HP:0007149)2.39597457
68Upper limb amyotrophy (HP:0009129)2.39597457
69Flat acetabular roof (HP:0003180)2.37699676
70Congenital hepatic fibrosis (HP:0002612)2.37680298
71Absent frontal sinuses (HP:0002688)2.37204380
72Arterial tortuosity (HP:0005116)2.28651285
73Cystic liver disease (HP:0006706)2.28607754
74Ovoid vertebral bodies (HP:0003300)2.26772195
75Increased cerebral lipofuscin (HP:0011813)2.24777399
76Hypoplasia of the odontoid process (HP:0003311)2.18098116
77Coarse hair (HP:0002208)2.15284181
78Pancreatic cysts (HP:0001737)2.13512204
79Abnormality of midbrain morphology (HP:0002418)2.11128474
80Molar tooth sign on MRI (HP:0002419)2.11128474
81Toxemia of pregnancy (HP:0100603)2.09819327
82Recurrent bronchitis (HP:0002837)2.09374570
83Nephronophthisis (HP:0000090)2.07488664
84Abnormality of the sella turcica (HP:0002679)2.05755231
85Abnormality of the thoracic spine (HP:0100711)2.04018043
86Vertebral hypoplasia (HP:0008417)2.03495001
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.03495001
88Systemic lupus erythematosus (HP:0002725)12.9502518
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0440548
90Abnormal respiratory epithelium morphology (HP:0012253)10.8723547
91Abnormal respiratory motile cilium morphology (HP:0005938)10.8723547
92Abnormal respiratory motile cilium physiology (HP:0012261)10.6651294
93Absent/shortened dynein arms (HP:0200106)10.5986010
94Dynein arm defect of respiratory motile cilia (HP:0012255)10.5986010
95Abnormal ciliary motility (HP:0012262)10.5401506
96Increased neuronal autofluorescent lipopigment (HP:0002074)1.96795223
97Chronic hepatic failure (HP:0100626)1.95991970
98Vascular tortuosity (HP:0004948)1.95559379
99Abnormality of the odontoid process (HP:0003310)1.94425644
100Postaxial foot polydactyly (HP:0001830)1.92144986
101Cellulitis (HP:0100658)1.89484508
102Spinal cord compression (HP:0002176)1.88395809
10311 pairs of ribs (HP:0000878)1.87377907
104Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87090388
105Disproportionate short-trunk short stature (HP:0003521)1.87017281
106Severe short stature (HP:0003510)1.86650160
107Esophageal varix (HP:0002040)1.86274115
108Synostosis involving the elbow (HP:0003938)1.85674695
109Humeroradial synostosis (HP:0003041)1.85674695
110Mediastinal lymphadenopathy (HP:0100721)1.85588878
111Neurofibrillary tangles (HP:0002185)1.84902632
112Bell-shaped thorax (HP:0001591)1.84876769
113Joint hemorrhage (HP:0005261)1.78713668
114Aqueductal stenosis (HP:0002410)1.73968812
115Prostate neoplasm (HP:0100787)1.73352735
116Thickened calvaria (HP:0002684)1.73110166
117Epistaxis (HP:0000421)1.69868374
118Radial bowing (HP:0002986)1.69824073
119Renal tubular acidosis (HP:0001947)1.69650874
120Abnormality of skull ossification (HP:0002703)1.68264401
121Pathologic fracture (HP:0002756)1.68022467
122Tubulointerstitial nephritis (HP:0001970)1.67094941
123Recurrent fungal infections (HP:0002841)1.65853682
124Coxa vara (HP:0002812)1.65490681
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65455054
126Recurrent skin infections (HP:0001581)1.65329823
127Abnormality of glycolipid metabolism (HP:0010969)1.64222045
128Abnormality of liposaccharide metabolism (HP:0010968)1.64222045
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.64222045
130Steatorrhea (HP:0002570)1.63721330
131Verrucae (HP:0200043)1.62525798
132Papilloma (HP:0012740)1.62525798
133Anencephaly (HP:0002323)1.61648932
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.60795658
135Abnormality of the renal medulla (HP:0100957)1.59688221
136Cerebral inclusion bodies (HP:0100314)1.59548999
137Progressive neurologic deterioration (HP:0002344)1.59420234
138Distal lower limb muscle weakness (HP:0009053)1.57347376
139Restrictive lung disease (HP:0002091)1.57111664
140Decreased circulating renin level (HP:0003351)1.54458398
141Disinhibition (HP:0000734)1.53982259
142Nephropathy (HP:0000112)1.53037993
143Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.51941991
144Renal salt wasting (HP:0000127)1.51380199
145Oculomotor apraxia (HP:0000657)1.50539446
146Abnormality of the frontal sinuses (HP:0002687)1.47716992
147Male pseudohermaphroditism (HP:0000037)1.47537673
148Hyperkalemia (HP:0002153)1.47199256
149Asplenia (HP:0001746)1.46583676
150Protuberant abdomen (HP:0001538)1.46414936
151Aplasia/Hypoplasia of the spleen (HP:0010451)1.42541167
152Tubular atrophy (HP:0000092)1.40578227
153Furrowed tongue (HP:0000221)1.38512753
154Abnormality of the distal phalanges of the toes (HP:0010182)1.36139113
155Ventricular fibrillation (HP:0001663)1.35302265
156Glucose intolerance (HP:0000833)1.34449850
157Cone-rod dystrophy (HP:0000548)1.33664127
158Medial flaring of the eyebrow (HP:0010747)1.30965219
159Fat malabsorption (HP:0002630)1.29188120
160Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.24649998
161Hyperaldosteronism (HP:0000859)1.24062506
162Congenital primary aphakia (HP:0007707)1.24059223
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.20755139
164Abnormality of chloride homeostasis (HP:0011422)1.20308181
165Obstructive sleep apnea (HP:0002870)1.19269178
166Gait imbalance (HP:0002141)1.18271182
167Alveolar cell carcinoma (HP:0006519)1.17910770
168Lip pit (HP:0100267)1.14397392
169Postaxial hand polydactyly (HP:0001162)1.13143997
170Abnormality of the dental root (HP:0006486)1.12053148
171Taurodontia (HP:0000679)1.12053148
172Abnormality of permanent molar morphology (HP:0011071)1.12053148
173Neoplasm of the tracheobronchial system (HP:0100552)1.11533901
174Abnormality of renin-angiotensin system (HP:0000847)1.10394028
175Sclerocornea (HP:0000647)1.09817444
176Spinal muscular atrophy (HP:0007269)1.09808986
177Short thorax (HP:0010306)1.09345563
178Abnormality of monocarboxylic acid metabolism (HP:0010996)1.06076956
179Tubulointerstitial abnormality (HP:0001969)1.05940848
180Nephrogenic diabetes insipidus (HP:0009806)1.05881440
181Multiple lipomas (HP:0001012)1.05734847
182Recurrent pneumonia (HP:0006532)1.05592739
183Hyponatremia (HP:0002902)1.05246114
184Abnormality of the dental pulp (HP:0006479)1.02036723
185Muscle fiber splitting (HP:0003555)1.01743354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.65815649
2MST1R8.49317521
3MST44.36412715
4BLK4.22104747
5MET3.41469400
6CAMK1D3.32599581
7ERN13.22069671
8DAPK23.13533825
9TRIB32.86085761
10RIPK12.82240463
11MAP4K12.68905683
12CAMK1G2.61933386
13BMX2.53191383
14PKN22.35823838
15SMG12.29254045
16MAP3K22.27492728
17TAOK32.12685029
18MAPKAPK32.11137399
19EPHB12.01319486
20GRK61.90520667
21EPHA21.71279275
22NEK91.60433568
23FES1.51373605
24TRPM71.47702720
25PTK61.45893134
26MAP3K111.42202011
27FGR1.40591259
28EPHB21.37231332
29IRAK41.36879786
30TYK21.34339682
31STK101.31229089
32DAPK11.29223716
33PRKCH1.28263893
34RIPK41.25866949
35CDC42BPA1.22042498
36TTN1.21534712
37CAMKK11.21017946
38CAMKK21.12548193
39NEK61.12203580
40ZAP701.11550757
41MAP3K131.11138705
42HCK1.08588116
43CSK1.06846730
44TBK10.99026533
45NME10.98817571
46SIK20.97732360
47MAP2K30.96026424
48TGFBR20.95884990
49LRRK20.94708269
50MARK20.94096531
51TTK0.91880083
52FGFR10.91504984
53PRKCI0.90835236
54ITK0.88244481
55GRK70.85717672
56EEF2K0.84950574
57STK380.84406701
58IGF1R0.81292857
59KIT0.80575108
60BTK0.80019992
61CDK60.79188412
62ICK0.77728489
63RPS6KA20.76541767
64MAP3K50.76434125
65PRKCQ0.75821098
66ERBB20.75082773
67DAPK30.70510836
68LCK0.69375522
69MAP3K100.65358413
70MAP3K70.64768832
71KSR20.63639553
72RPS6KC10.63321102
73RPS6KL10.63321102
74YES10.62569174
75PTK20.62044644
76MAP3K60.61245255
77RPS6KA60.60930633
78MARK30.58760576
79FER0.58489817
80SGK30.58287372
81PNCK0.58275904
82NTRK10.57664281
83FYN0.57084066
84SYK0.54837550
85TESK10.54406013
86RPS6KA40.54210371
87EGFR0.53992866
88SGK10.53225389
89MAPK120.52703322
90CLK10.52414796
91STK38L0.52112455
92JAK10.50473054
93PRKD30.50408106
94GRK50.49070314
95SGK20.48471011
96BCR0.47712095
97CSF1R0.47648678
98MAP3K140.47423986
99PDPK10.47314687
100ARAF0.45617099
101LIMK10.44238809
102MATK0.44176993
103MAP3K80.44056037
104ABL10.40991595
105MAP3K10.40290338
106PIK3CG0.39821035
107TAOK10.39445312
108MAPKAPK20.37031074
109IKBKB0.35573612
110TXK0.35167964
111MAP2K40.35093282
112HIPK20.34284170
113CAMK10.33829493
114ROCK20.33788119
115PTK2B0.33668874
116CAMK40.33096355
117DYRK1B0.32733191
118ADRBK20.31163281
119JAK20.30065111
120LYN0.27556540
121PDK10.27034737
122CDK120.26270289
123RET0.25814788
124JAK30.25634601
125PRKCE0.25331351
126ERBB30.24558363
127TEC0.24510127
128CDK40.24451167
129MAPKAPK50.23098259
130MAP3K90.23040021
131PIM20.22289115
132EPHA30.22235945
133PRKCD0.21991438
134CAMK2G0.21796712
135PKN10.20976791
136SRC0.18515669
137IKBKE0.18307087
138PRKAA20.17893739
139PAK40.14579967
140ILK0.13036675
141SIK10.11979758
142PRPF4B0.09222480
143STK240.08784028
144MAP3K30.08494506
145CDK80.08160318

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051508.77870725
2Other glycan degradation_Homo sapiens_hsa005116.29485368
3Complement and coagulation cascades_Homo sapiens_hsa046104.47671873
4Glycosaminoglycan degradation_Homo sapiens_hsa005314.19128713
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.02050954
6Phenylalanine metabolism_Homo sapiens_hsa003603.57131853
7Pertussis_Homo sapiens_hsa051333.56635251
8Chemical carcinogenesis_Homo sapiens_hsa052043.10677049
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.00835543
10Caffeine metabolism_Homo sapiens_hsa002322.68261574
11Tyrosine metabolism_Homo sapiens_hsa003502.66476014
12Leishmaniasis_Homo sapiens_hsa051402.39909304
13Prion diseases_Homo sapiens_hsa050202.12985997
14Lysosome_Homo sapiens_hsa041422.10405584
15beta-Alanine metabolism_Homo sapiens_hsa004101.92396365
16Malaria_Homo sapiens_hsa051441.91906892
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.89421743
18Asthma_Homo sapiens_hsa053101.64541289
19Allograft rejection_Homo sapiens_hsa053301.62179308
20Steroid biosynthesis_Homo sapiens_hsa001001.60410899
21Autoimmune thyroid disease_Homo sapiens_hsa053201.53858742
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52474055
23Glutathione metabolism_Homo sapiens_hsa004801.52455735
24Amoebiasis_Homo sapiens_hsa051461.46770237
25Graft-versus-host disease_Homo sapiens_hsa053321.43296940
26Retinol metabolism_Homo sapiens_hsa008301.39614701
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36994271
28Legionellosis_Homo sapiens_hsa051341.34991972
29* Arachidonic acid metabolism_Homo sapiens_hsa005901.28320735
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26966771
31Type I diabetes mellitus_Homo sapiens_hsa049401.19846678
32Huntingtons disease_Homo sapiens_hsa050161.17961799
33Phagosome_Homo sapiens_hsa041451.16549934
34Hematopoietic cell lineage_Homo sapiens_hsa046401.13322954
35Chemokine signaling pathway_Homo sapiens_hsa040621.13253518
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12711629
37Osteoclast differentiation_Homo sapiens_hsa043801.10521295
38Tuberculosis_Homo sapiens_hsa051521.09753775
39Nitrogen metabolism_Homo sapiens_hsa009101.08112878
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.05737377
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03976261
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01596706
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99847615
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92353774
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90632542
46Platelet activation_Homo sapiens_hsa046110.90408164
47Toxoplasmosis_Homo sapiens_hsa051450.87989245
48Histidine metabolism_Homo sapiens_hsa003400.79185388
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78144339
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.75705399
51Choline metabolism in cancer_Homo sapiens_hsa052310.74705401
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74010465
53Tight junction_Homo sapiens_hsa045300.72978918
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70723881
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70305229
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70169505
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70023454
58Salivary secretion_Homo sapiens_hsa049700.68283873
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.67584354
60Salmonella infection_Homo sapiens_hsa051320.67456861
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66792048
62Arginine biosynthesis_Homo sapiens_hsa002200.65320586
63Proteoglycans in cancer_Homo sapiens_hsa052050.65012681
64B cell receptor signaling pathway_Homo sapiens_hsa046620.64299115
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62089457
66Systemic lupus erythematosus_Homo sapiens_hsa053220.61338448
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.59900556
68Shigellosis_Homo sapiens_hsa051310.59391330
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56516216
70Fatty acid degradation_Homo sapiens_hsa000710.54267216
71Rap1 signaling pathway_Homo sapiens_hsa040150.52663201
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50592858
73Peroxisome_Homo sapiens_hsa041460.49251676
74Lysine degradation_Homo sapiens_hsa003100.48018199
75N-Glycan biosynthesis_Homo sapiens_hsa005100.47316434
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47242029
77ABC transporters_Homo sapiens_hsa020100.45746443
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45243686
79Acute myeloid leukemia_Homo sapiens_hsa052210.43469107
80Small cell lung cancer_Homo sapiens_hsa052220.41418384
81Chronic myeloid leukemia_Homo sapiens_hsa052200.40886015
82mTOR signaling pathway_Homo sapiens_hsa041500.40631858
83Endocytosis_Homo sapiens_hsa041440.38979264
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38050718
85Collecting duct acid secretion_Homo sapiens_hsa049660.37981052
86Pancreatic cancer_Homo sapiens_hsa052120.37050303
87Viral myocarditis_Homo sapiens_hsa054160.36685719
88cAMP signaling pathway_Homo sapiens_hsa040240.36644031
89Focal adhesion_Homo sapiens_hsa045100.36357857
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36009768
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35608353
92Rheumatoid arthritis_Homo sapiens_hsa053230.34970882
93Adherens junction_Homo sapiens_hsa045200.34205306
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.33286873
95Olfactory transduction_Homo sapiens_hsa047400.32671188
96Circadian rhythm_Homo sapiens_hsa047100.31996806
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.31600282
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31079539
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30503295
100Vibrio cholerae infection_Homo sapiens_hsa051100.30111054
101Sphingolipid metabolism_Homo sapiens_hsa006000.30027476
102Fructose and mannose metabolism_Homo sapiens_hsa000510.29768396
103Starch and sucrose metabolism_Homo sapiens_hsa005000.29598968
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.29111879
105Antigen processing and presentation_Homo sapiens_hsa046120.28739509
106MAPK signaling pathway_Homo sapiens_hsa040100.27995317
107Renin secretion_Homo sapiens_hsa049240.27853711
108ECM-receptor interaction_Homo sapiens_hsa045120.27168362
109Ovarian steroidogenesis_Homo sapiens_hsa049130.26835632
110Morphine addiction_Homo sapiens_hsa050320.26476633
111Pathways in cancer_Homo sapiens_hsa052000.26005939
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.25025497
113VEGF signaling pathway_Homo sapiens_hsa043700.25011162
114Insulin resistance_Homo sapiens_hsa049310.24840584
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24555962
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21814026
117Hepatitis C_Homo sapiens_hsa051600.21813907
118Notch signaling pathway_Homo sapiens_hsa043300.21810771
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.21334535
120Measles_Homo sapiens_hsa051620.20543306
121Influenza A_Homo sapiens_hsa051640.20005806
122Renal cell carcinoma_Homo sapiens_hsa052110.19470471
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.18965093
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18762084
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17812575
126TNF signaling pathway_Homo sapiens_hsa046680.16842067
127Apoptosis_Homo sapiens_hsa042100.15659147
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15296436
129Sulfur relay system_Homo sapiens_hsa041220.14676561
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.14669074
131Hepatitis B_Homo sapiens_hsa051610.12563164
132Galactose metabolism_Homo sapiens_hsa000520.12396860
133Herpes simplex infection_Homo sapiens_hsa051680.12262187
134Dilated cardiomyopathy_Homo sapiens_hsa054140.10035088
135Non-small cell lung cancer_Homo sapiens_hsa052230.09514019
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09197454
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.07720070
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.07461776
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07387225
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07193844
141Colorectal cancer_Homo sapiens_hsa052100.06888415

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