ALKBH4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.41545319
2DNA deamination (GO:0045006)5.21616785
3maturation of SSU-rRNA (GO:0030490)5.21196431
4chaperone-mediated protein transport (GO:0072321)4.77042259
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.69782682
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.61341483
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.61341483
8NADH dehydrogenase complex assembly (GO:0010257)4.61341483
9protein complex biogenesis (GO:0070271)4.57660992
10mitochondrial respiratory chain complex assembly (GO:0033108)4.55147378
11viral transcription (GO:0019083)4.42645244
12translational termination (GO:0006415)4.29134908
13ribosomal small subunit biogenesis (GO:0042274)4.07828100
14ATP synthesis coupled proton transport (GO:0015986)4.05541128
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05541128
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04673368
17formation of translation preinitiation complex (GO:0001731)4.03440727
18respiratory chain complex IV assembly (GO:0008535)3.98410264
19translational elongation (GO:0006414)3.92756759
20DNA replication checkpoint (GO:0000076)3.91804156
21pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.87664258
22behavioral response to nicotine (GO:0035095)3.82635696
23regulation of mitochondrial translation (GO:0070129)3.82200510
24translational initiation (GO:0006413)3.80561389
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.80215005
26DNA strand elongation involved in DNA replication (GO:0006271)3.78764068
27GTP biosynthetic process (GO:0006183)3.74243063
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70336984
29cytochrome complex assembly (GO:0017004)3.67054541
30peptidyl-histidine modification (GO:0018202)3.65098885
31ribosomal large subunit biogenesis (GO:0042273)3.63340302
32DNA strand elongation (GO:0022616)3.61883819
33telomere maintenance via semi-conservative replication (GO:0032201)3.60722194
34protein targeting to mitochondrion (GO:0006626)3.60126200
35DNA replication initiation (GO:0006270)3.59137705
36cotranslational protein targeting to membrane (GO:0006613)3.58997168
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58522962
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.58522962
39protein targeting to ER (GO:0045047)3.57531662
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53163660
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.52894470
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.52894470
43protein-cofactor linkage (GO:0018065)3.52845870
44ribonucleoprotein complex biogenesis (GO:0022613)3.52360756
45base-excision repair, AP site formation (GO:0006285)3.50526682
46mitochondrial RNA metabolic process (GO:0000959)3.48829171
47establishment of protein localization to mitochondrion (GO:0072655)3.48067686
48cellular protein complex disassembly (GO:0043624)3.43967037
49protein localization to endoplasmic reticulum (GO:0070972)3.40938042
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39543700
51electron transport chain (GO:0022900)3.39013418
52respiratory electron transport chain (GO:0022904)3.38662711
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37560991
54viral life cycle (GO:0019058)3.37293828
55UTP biosynthetic process (GO:0006228)3.36715032
56rRNA processing (GO:0006364)3.35066096
57ribosome biogenesis (GO:0042254)3.34890757
58water-soluble vitamin biosynthetic process (GO:0042364)3.31217131
59Arp2/3 complex-mediated actin nucleation (GO:0034314)3.29474019
60protein localization to mitochondrion (GO:0070585)3.29454769
61intracellular protein transmembrane import (GO:0044743)3.29182610
62rRNA metabolic process (GO:0016072)3.28509351
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.26689449
64replication fork processing (GO:0031297)3.24561189
65platelet dense granule organization (GO:0060155)3.22844660
66pyrimidine nucleotide catabolic process (GO:0006244)3.22726067
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20197105
68antigen processing and presentation of endogenous antigen (GO:0019883)3.18307515
69protein complex disassembly (GO:0043241)3.18162075
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17732445
71maturation of 5.8S rRNA (GO:0000460)3.17193530
72DNA unwinding involved in DNA replication (GO:0006268)3.16566089
73purine nucleobase biosynthetic process (GO:0009113)3.16016172
74pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.15216808
75UTP metabolic process (GO:0046051)3.13949863
76proteasome assembly (GO:0043248)3.13618108
77anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13607956
78guanosine-containing compound biosynthetic process (GO:1901070)3.13394900
79telomere maintenance via recombination (GO:0000722)3.13268478
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11498609
81negative regulation of ligase activity (GO:0051352)3.11498609
82mannosylation (GO:0097502)3.10980182
83pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.10524082
84negative regulation of telomere maintenance (GO:0032205)3.10142472
85nucleobase biosynthetic process (GO:0046112)3.09902920
86protein localization to chromosome, centromeric region (GO:0071459)3.09075572
87iron-sulfur cluster assembly (GO:0016226)3.08970686
88metallo-sulfur cluster assembly (GO:0031163)3.08970686
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08845839
90macromolecular complex disassembly (GO:0032984)3.08161755
91tRNA processing (GO:0008033)3.07740520
92viral mRNA export from host cell nucleus (GO:0046784)3.07137052
93deoxyribonucleotide catabolic process (GO:0009264)3.07020519
94spliceosomal snRNP assembly (GO:0000387)3.06694128
95translation (GO:0006412)3.06459654
96DNA damage response, detection of DNA damage (GO:0042769)3.05459288
97nuclear-transcribed mRNA catabolic process (GO:0000956)3.03711270
98transcription from mitochondrial promoter (GO:0006390)3.02771137
99rRNA modification (GO:0000154)3.02737073
100DNA double-strand break processing (GO:0000729)3.00448046
101deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98182105
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97929036
103nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.97538999
104CTP metabolic process (GO:0046036)2.96931442
105CTP biosynthetic process (GO:0006241)2.96931442
106positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96657121
107regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96088014
108preassembly of GPI anchor in ER membrane (GO:0016254)2.94804437
109mitotic metaphase plate congression (GO:0007080)2.94182553
110cullin deneddylation (GO:0010388)2.93995962
111inner mitochondrial membrane organization (GO:0007007)2.93586867
112DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.91083056
113mRNA catabolic process (GO:0006402)2.90157012
114purine nucleoside triphosphate biosynthetic process (GO:0009145)2.89557873
115purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89185161
116protein deneddylation (GO:0000338)2.88302568
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.88135825
118telomere maintenance via telomere lengthening (GO:0010833)2.87599415
119ribosome assembly (GO:0042255)2.87281587
120deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.86594111
121positive regulation of gamma-delta T cell activation (GO:0046645)2.86508048
122signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86301440
123signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86301440
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86301440
125intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85963018
126signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85963018
127protein localization to kinetochore (GO:0034501)2.85602174
128somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85377020
129somatic hypermutation of immunoglobulin genes (GO:0016446)2.85377020
130antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85352219
131mitotic nuclear envelope disassembly (GO:0007077)2.84520919
132regulation of nuclear cell cycle DNA replication (GO:0033262)2.84460667
133nucleotide-excision repair, DNA gap filling (GO:0006297)2.83982086
134GMP metabolic process (GO:0046037)2.83697601
135RNA catabolic process (GO:0006401)2.83439834
136mitotic recombination (GO:0006312)2.81962691
137deoxyribose phosphate catabolic process (GO:0046386)2.80195211
138folic acid metabolic process (GO:0046655)2.79993796
139positive regulation of prostaglandin secretion (GO:0032308)2.79205220
140tRNA modification (GO:0006400)2.79148126
141signal transduction involved in DNA damage checkpoint (GO:0072422)2.78877232
142signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78877232
143pseudouridine synthesis (GO:0001522)2.78825044
144IMP biosynthetic process (GO:0006188)2.78437013
145histone mRNA metabolic process (GO:0008334)2.77181216
146negative regulation of B cell apoptotic process (GO:0002903)2.77072337
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.77000660
148sequestering of actin monomers (GO:0042989)2.76919242
149pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.74122953
150regulation of cellular amino acid metabolic process (GO:0006521)2.72884107
151signal transduction involved in cell cycle checkpoint (GO:0072395)2.72800765
152ubiquinone biosynthetic process (GO:0006744)2.72539933
153antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72500841
154DNA catabolic process, exonucleolytic (GO:0000738)2.72084462
1557-methylguanosine mRNA capping (GO:0006370)2.71941756
156regulation of helicase activity (GO:0051095)2.70480608
157establishment of integrated proviral latency (GO:0075713)2.70376366
158tRNA metabolic process (GO:0006399)2.68633255
159protein neddylation (GO:0045116)2.68520988
160IMP metabolic process (GO:0046040)2.68405125
1612-deoxyribonucleotide metabolic process (GO:0009394)2.68075330
162CENP-A containing nucleosome assembly (GO:0034080)2.67430058
163G1/S transition of mitotic cell cycle (GO:0000082)2.67240381
164cell cycle G1/S phase transition (GO:0044843)2.67240381
165positive regulation of ligase activity (GO:0051351)2.67043834
166transcription-coupled nucleotide-excision repair (GO:0006283)2.63816220
167cellular component biogenesis (GO:0044085)2.63256916
168chromatin remodeling at centromere (GO:0031055)2.62081814
169rRNA methylation (GO:0031167)2.61135969
170histone H2A acetylation (GO:0043968)2.60050112
171ncRNA processing (GO:0034470)2.59349531
172transcription elongation from RNA polymerase III promoter (GO:0006385)2.57693141
173termination of RNA polymerase III transcription (GO:0006386)2.57693141
174nuclear envelope disassembly (GO:0051081)2.57389422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25926523
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85607890
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.72358734
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85408805
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.83981668
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.81817628
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74955797
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.71660842
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67801501
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56125747
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53870263
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.46447948
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46085411
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45811776
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45778904
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41958894
17ZNF274_21170338_ChIP-Seq_K562_Hela2.32611494
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31718040
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30249806
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.27927617
21VDR_23849224_ChIP-Seq_CD4+_Human2.25747295
22XRN2_22483619_ChIP-Seq_HELA_Human2.22942885
23MYC_22102868_ChIP-Seq_BL_Human2.21370984
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15958997
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12279739
26FOXP3_21729870_ChIP-Seq_TREG_Human2.05441223
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97604164
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96452920
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95533657
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.94643055
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92646231
32* GABP_19822575_ChIP-Seq_HepG2_Human1.91352683
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84899589
34DCP1A_22483619_ChIP-Seq_HELA_Human1.84252752
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81225840
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.80733759
37CIITA_25753668_ChIP-Seq_RAJI_Human1.79386421
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76407162
39MYC_18940864_ChIP-ChIP_HL60_Human1.75706743
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.75347715
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74254959
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70521387
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.70456574
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70234750
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67085625
46IRF1_19129219_ChIP-ChIP_H3396_Human1.66310032
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61642128
48TTF2_22483619_ChIP-Seq_HELA_Human1.60284762
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59764214
50VDR_21846776_ChIP-Seq_THP-1_Human1.57426259
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.57300305
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56207588
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53552482
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53280191
55MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50433160
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.50090129
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.48253181
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47615543
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47572191
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44431584
61SCL_19346495_ChIP-Seq_HPC-7_Human1.44409562
62SPI1_23547873_ChIP-Seq_NB4_Human1.44131662
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43404704
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42452985
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.39869366
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39283108
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38303057
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38002932
69ELK1_19687146_ChIP-ChIP_HELA_Human1.37945802
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36534832
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34631542
72FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31131990
73MAF_26560356_Chip-Seq_TH1_Human1.30668319
74KDM5A_27292631_Chip-Seq_BREAST_Human1.30169472
75TP53_22573176_ChIP-Seq_HFKS_Human1.28693962
76UTX_26944678_Chip-Seq_JUKART_Human1.27710838
77MYB_26560356_Chip-Seq_TH2_Human1.27232514
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.27131101
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24923890
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24640683
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.24512787
82* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.23683736
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21481317
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20192501
85* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18808914
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16430578
87MYB_26560356_Chip-Seq_TH1_Human1.16342321
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15681128
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.14988792
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14372586
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13934438
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13611848
93* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13369414
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.12456146
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12418980
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11476101
97MAF_26560356_Chip-Seq_TH2_Human1.11393448
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11112186
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07618078
100TFEB_21752829_ChIP-Seq_HELA_Human1.07065335
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.03693840
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03050878
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02534303
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00929522
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00744889
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00149854
107AR_21909140_ChIP-Seq_LNCAP_Human1.00124645
108RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00088601
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98697770
110ERA_21632823_ChIP-Seq_H3396_Human0.96884494
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96770998
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96481673
113BCL6_27268052_Chip-Seq_Bcells_Human0.95643365
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93895799
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93533363
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93485566
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93003693
118HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92996288
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92570401
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91823855
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90835998
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.90768056
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90519071
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90352297
125CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89317496
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87449310
127YY1_22570637_ChIP-Seq_MALME-3M_Human0.86216606
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.86101488
129NANOG_20526341_ChIP-Seq_ESCs_Human0.85575479
130* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84227927
131KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82361517
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81406260
133CTCF_26484167_Chip-Seq_Bcells_Mouse0.80837418
134* E2F1_20622854_ChIP-Seq_HELA_Human0.80601345
135* PHF8_20622854_ChIP-Seq_HELA_Human0.80384039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.10270763
2MP0004957_abnormal_blastocyst_morpholog3.39988330
3MP0003111_abnormal_nucleus_morphology3.31782599
4MP0010094_abnormal_chromosome_stability3.30778675
5MP0003763_abnormal_thymus_physiology3.28492396
6MP0002396_abnormal_hematopoietic_system3.23692755
7MP0003077_abnormal_cell_cycle3.07003939
8MP0008007_abnormal_cellular_replicative2.68520708
9MP0002653_abnormal_ependyma_morphology2.68160749
10MP0008057_abnormal_DNA_replication2.62979248
11MP0005671_abnormal_response_to2.55273068
12MP0001835_abnormal_antigen_presentation2.55015143
13MP0000685_abnormal_immune_system2.52869163
14MP0008058_abnormal_DNA_repair2.49255027
15MP0002398_abnormal_bone_marrow2.43219554
16MP0003787_abnormal_imprinting2.34138354
17MP0001968_abnormal_touch/_nociception2.26843370
18MP0001545_abnormal_hematopoietic_system2.26056041
19MP0005397_hematopoietic_system_phenotyp2.26056041
20MP0002163_abnormal_gland_morphology2.24443000
21MP0009333_abnormal_splenocyte_physiolog2.23791589
22MP0002736_abnormal_nociception_after2.18772393
23MP0009785_altered_susceptibility_to2.17187644
24MP0000689_abnormal_spleen_morphology2.16677567
25MP0002722_abnormal_immune_system2.16029118
26MP0004808_abnormal_hematopoietic_stem2.13285037
27MP0003011_delayed_dark_adaptation2.09362315
28MP0001800_abnormal_humoral_immune2.02910024
29MP0000703_abnormal_thymus_morphology2.02362471
30MP0001919_abnormal_reproductive_system1.99989447
31MP0000716_abnormal_immune_system1.99471161
32MP0002254_reproductive_system_inflammat1.97745081
33MP0002420_abnormal_adaptive_immunity1.96153090
34MP0001819_abnormal_immune_cell1.93942513
35MP0002837_dystrophic_cardiac_calcinosis1.90507528
36MP0005551_abnormal_eye_electrophysiolog1.89791566
37MP0002723_abnormal_immune_serum1.88410916
38MP0005025_abnormal_response_to1.88176202
39MP0002429_abnormal_blood_cell1.87821981
40MP0000490_abnormal_crypts_of1.87498905
41MP0002102_abnormal_ear_morphology1.86996217
42MP0003786_premature_aging1.84551609
43MP0001529_abnormal_vocalization1.79464246
44MP0002452_abnormal_antigen_presenting1.78604774
45MP0006072_abnormal_retinal_apoptosis1.75929785
46MP0008875_abnormal_xenobiotic_pharmacok1.75153649
47MP0004142_abnormal_muscle_tone1.73292586
48MP0005389_reproductive_system_phenotype1.70483575
49MP0008872_abnormal_physiological_respon1.69152793
50MP0000350_abnormal_cell_proliferation1.68006540
51MP0002277_abnormal_respiratory_mucosa1.66061087
52MP0002019_abnormal_tumor_incidence1.65221381
53MP0005000_abnormal_immune_tolerance1.64898135
54MP0006276_abnormal_autonomic_nervous1.64811249
55MP0001730_embryonic_growth_arrest1.58981890
56MP0008932_abnormal_embryonic_tissue1.58223736
57MP0002166_altered_tumor_susceptibility1.55961909
58MP0010307_abnormal_tumor_latency1.55759758
59MP0000313_abnormal_cell_death1.55101298
60MP0001764_abnormal_homeostasis1.54374966
61MP0003436_decreased_susceptibility_to1.53150980
62MP0000858_altered_metastatic_potential1.51807787
63MP0002405_respiratory_system_inflammati1.51182028
64MP0005379_endocrine/exocrine_gland_phen1.51067228
65MP0001853_heart_inflammation1.50494479
66MP0001873_stomach_inflammation1.48889228
67MP0000372_irregular_coat_pigmentation1.46650978
68MP0010352_gastrointestinal_tract_polyps1.46572657
69MP0008789_abnormal_olfactory_epithelium1.45869206
70MP0003121_genomic_imprinting1.45477005
71MP0005387_immune_system_phenotype1.43305039
72MP0001790_abnormal_immune_system1.43305039
73MP0005084_abnormal_gallbladder_morpholo1.40497186
74MP0009697_abnormal_copulation1.38369624
75MP0002132_abnormal_respiratory_system1.38150440
76MP0002938_white_spotting1.36450764
77MP0008877_abnormal_DNA_methylation1.34189840
78MP0004133_heterotaxia1.33916575
79MP0000049_abnormal_middle_ear1.31834774
80MP0003880_abnormal_central_pattern1.28548477
81MP0003656_abnormal_erythrocyte_physiolo1.27463336
82MP0001984_abnormal_olfaction1.27460604
83MP0003646_muscle_fatigue1.25085377
84MP0002419_abnormal_innate_immunity1.24912628
85MP0000465_gastrointestinal_hemorrhage1.24494856
86MP0005253_abnormal_eye_physiology1.23526112
87MP0001905_abnormal_dopamine_level1.22432493
88MP0003866_abnormal_defecation1.20809725
89MP0003136_yellow_coat_color1.20603916
90MP0010155_abnormal_intestine_physiology1.18485739
91MP0005464_abnormal_platelet_physiology1.18308758
92MP0003123_paternal_imprinting1.17782062
93MP0004947_skin_inflammation1.16993320
94MP0001845_abnormal_inflammatory_respons1.15844184
95MP0003724_increased_susceptibility_to1.15016191
96MP0002080_prenatal_lethality1.14016758
97MP0002148_abnormal_hypersensitivity_rea1.13580930
98MP0002006_tumorigenesis1.12327597
99MP0001697_abnormal_embryo_size1.11266319
100MP0005075_abnormal_melanosome_morpholog1.11103680
101MP0005410_abnormal_fertilization1.10899047
102MP0005367_renal/urinary_system_phenotyp1.10413069
103MP0000516_abnormal_urinary_system1.10413069
104MP0009745_abnormal_behavioral_response1.10284300
105MP0002234_abnormal_pharynx_morphology1.09558408
106MP0001293_anophthalmia1.09422883
107MP0005174_abnormal_tail_pigmentation1.08598566
108MP0003806_abnormal_nucleotide_metabolis1.06463420
109MP0006082_CNS_inflammation1.06014389
110MP0005394_taste/olfaction_phenotype1.05703591
111MP0005499_abnormal_olfactory_system1.05703591
112MP0005646_abnormal_pituitary_gland1.03788979
113MP0000631_abnormal_neuroendocrine_gland1.02469092
114MP0005645_abnormal_hypothalamus_physiol1.01592526
115MP0001986_abnormal_taste_sensitivity1.01399609
116MP0005332_abnormal_amino_acid0.98927253
117MP0008469_abnormal_protein_level0.98631746
118MP0009379_abnormal_foot_pigmentation0.97674934
119MP0004147_increased_porphyrin_level0.97210139
120MP0005380_embryogenesis_phenotype0.96589002
121MP0001672_abnormal_embryogenesis/_devel0.96589002
122MP0000358_abnormal_cell_content/0.96474200
123MP0003448_altered_tumor_morphology0.95230780
124MP0003984_embryonic_growth_retardation0.92963293
125MP0003186_abnormal_redox_activity0.92637060
126MP0001324_abnormal_eye_pigmentation0.91847526
127MP0002638_abnormal_pupillary_reflex0.91763526
128MP0002088_abnormal_embryonic_growth/wei0.90435374
129MP0001929_abnormal_gametogenesis0.88510688
130MP0006036_abnormal_mitochondrial_physio0.88497843
131MP0009046_muscle_twitch0.87617362
132MP0002928_abnormal_bile_duct0.87591253
133MP0003567_abnormal_fetal_cardiomyocyte0.86563165
134MP0003315_abnormal_perineum_morphology0.85412608
135MP0002210_abnormal_sex_determination0.85066846
136MP0002086_abnormal_extraembryonic_tissu0.84898281
137MP0006054_spinal_hemorrhage0.84538994
138MP0000015_abnormal_ear_pigmentation0.84259552
139MP0005195_abnormal_posterior_eye0.84119606
140MP0002095_abnormal_skin_pigmentation0.83254768
141MP0003698_abnormal_male_reproductive0.82964246
142MP0009278_abnormal_bone_marrow0.82181763
143MP0003718_maternal_effect0.78538392
144MP0001145_abnormal_male_reproductive0.77905453
145MP0000538_abnormal_urinary_bladder0.74584100
146MP0002272_abnormal_nervous_system0.72947795
147MP0000477_abnormal_intestine_morphology0.72671286
148MP0001119_abnormal_female_reproductive0.72177201
149MP0001485_abnormal_pinna_reflex0.72072186
150MP0002557_abnormal_social/conspecific_i0.72065114
151MP0004742_abnormal_vestibular_system0.71959993
152MP0000598_abnormal_liver_morphology0.71623323
153MP0002751_abnormal_autonomic_nervous0.70707099
154MP0000647_abnormal_sebaceous_gland0.70352760
155MP0001661_extended_life_span0.69767128
156MP0002064_seizures0.69626927
157MP0002752_abnormal_somatic_nervous0.68937073
158MP0002138_abnormal_hepatobiliary_system0.68796380
159MP0002572_abnormal_emotion/affect_behav0.67801183
160MP0004197_abnormal_fetal_growth/weight/0.67269210
161MP0001188_hyperpigmentation0.66579200
162MP0006292_abnormal_olfactory_placode0.66534877
163MP0002933_joint_inflammation0.66344062
164MP0005023_abnormal_wound_healing0.65392774
165MP0002085_abnormal_embryonic_tissue0.64930770
166MP0000427_abnormal_hair_cycle0.64682901
167MP0002160_abnormal_reproductive_system0.64224748
168MP0006035_abnormal_mitochondrial_morpho0.62972334
169MP0000653_abnormal_sex_gland0.62355514

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.09109771
2Abnormality of cells of the erythroid lineage (HP:0012130)5.04069352
3Abnormal number of erythroid precursors (HP:0012131)4.61771389
4Thrombocytosis (HP:0001894)4.28582735
5Acute necrotizing encephalopathy (HP:0006965)4.15147009
6Birth length less than 3rd percentile (HP:0003561)4.07929537
7Mitochondrial inheritance (HP:0001427)4.07065911
8Abnormal mitochondria in muscle tissue (HP:0008316)4.05364233
9Acute encephalopathy (HP:0006846)3.78621678
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.77609436
11Lipid accumulation in hepatocytes (HP:0006561)3.75535850
12IgM deficiency (HP:0002850)3.73586900
13Chronic otitis media (HP:0000389)3.70053101
14Increased CSF lactate (HP:0002490)3.69281414
15Elevated erythrocyte sedimentation rate (HP:0003565)3.63989658
16Increased hepatocellular lipid droplets (HP:0006565)3.61716475
17Hepatocellular necrosis (HP:0001404)3.56050507
18Recurrent bronchitis (HP:0002837)3.51829122
19Pallor (HP:0000980)3.48284094
20Progressive macrocephaly (HP:0004481)3.42717911
21Increased intramyocellular lipid droplets (HP:0012240)3.39433413
22Aplastic anemia (HP:0001915)3.39149004
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.25659187
24Type 2 muscle fiber atrophy (HP:0003554)3.18168996
25Severe combined immunodeficiency (HP:0004430)3.17796912
26Increased muscle lipid content (HP:0009058)3.14430337
27Muscle fiber atrophy (HP:0100295)3.13406849
28Hepatic necrosis (HP:0002605)3.08922954
29Type II lissencephaly (HP:0007260)3.08050303
30Abnormality of the anterior horn cell (HP:0006802)3.06660473
31Degeneration of anterior horn cells (HP:0002398)3.06660473
32Nasal polyposis (HP:0100582)3.05174274
33Macrocytic anemia (HP:0001972)3.04905638
34Combined immunodeficiency (HP:0005387)3.03121442
35Panhypogammaglobulinemia (HP:0003139)3.01950397
36Microretrognathia (HP:0000308)2.96600145
37Reduced antithrombin III activity (HP:0001976)2.95501740
38Renal Fanconi syndrome (HP:0001994)2.95117998
39T lymphocytopenia (HP:0005403)2.95088183
40Increased serum lactate (HP:0002151)2.92192082
41Breast hypoplasia (HP:0003187)2.91970814
42Abnormality of T cells (HP:0002843)2.90714690
43IgG deficiency (HP:0004315)2.87926055
44Lactic acidosis (HP:0003128)2.83743890
45Abnormality of T cell number (HP:0011839)2.79590966
46Pancreatic cysts (HP:0001737)2.79240233
47Abnormality of midbrain morphology (HP:0002418)2.76333812
48Molar tooth sign on MRI (HP:0002419)2.76333812
49Chromsome breakage (HP:0040012)2.71165826
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70768785
51Cerebral edema (HP:0002181)2.69090526
52Abnormality of the nasal mucosa (HP:0000433)2.67691642
53Pancreatic fibrosis (HP:0100732)2.66687383
54Abnormal rod and cone electroretinograms (HP:0008323)2.64239889
55Testicular atrophy (HP:0000029)2.61262284
56Type I transferrin isoform profile (HP:0003642)2.60865992
57Recurrent viral infections (HP:0004429)2.60318151
58Pendular nystagmus (HP:0012043)2.58096225
59Congenital stationary night blindness (HP:0007642)2.54730442
60Spinal cord lesions (HP:0100561)2.54309841
61Syringomyelia (HP:0003396)2.54309841
62Myelodysplasia (HP:0002863)2.54249380
63Methylmalonic aciduria (HP:0012120)2.50940592
64Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49840495
65Abnormality of T cell physiology (HP:0011840)2.49815670
66Petechiae (HP:0000967)2.48062294
67Pancytopenia (HP:0001876)2.47888819
68True hermaphroditism (HP:0010459)2.45790305
69Agammaglobulinemia (HP:0004432)2.44971119
70B lymphocytopenia (HP:0010976)2.44124923
71Abnormality of B cell number (HP:0010975)2.44124923
72Hypoplasia of the pons (HP:0012110)2.43939624
73Lymphoma (HP:0002665)2.43279704
74Exertional dyspnea (HP:0002875)2.42079138
75Recurrent fungal infections (HP:0002841)2.39065688
76Abnormality of the pons (HP:0007361)2.36710496
77Absent thumb (HP:0009777)2.36518548
78Microvesicular hepatic steatosis (HP:0001414)2.34666976
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.34492250
803-Methylglutaconic aciduria (HP:0003535)2.33943790
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33747520
82Abnormality of alanine metabolism (HP:0010916)2.33747520
83Hyperalaninemia (HP:0003348)2.33747520
84Rough bone trabeculation (HP:0100670)2.30428942
85Abnormal protein glycosylation (HP:0012346)2.29597518
86Abnormal glycosylation (HP:0012345)2.29597518
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.29597518
88Abnormal protein N-linked glycosylation (HP:0012347)2.29597518
89Mediastinal lymphadenopathy (HP:0100721)2.28895703
90Hyperglycinemia (HP:0002154)2.28247057
91Progressive microcephaly (HP:0000253)2.28174232
92Chronic mucocutaneous candidiasis (HP:0002728)2.25798794
93Recurrent cutaneous fungal infections (HP:0011370)2.25798794
94Amaurosis fugax (HP:0100576)2.25535879
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24742568
96Optic disc pallor (HP:0000543)2.24645033
97Bronchitis (HP:0012387)2.23632366
98Cerebral hypomyelination (HP:0006808)2.23180489
99Abnormality of reticulocytes (HP:0004312)2.22294154
100Recurrent abscess formation (HP:0002722)2.21862018
101Exercise intolerance (HP:0003546)2.18909841
102Abnormality of cells of the lymphoid lineage (HP:0012140)2.18423503
103Respiratory difficulties (HP:0002880)2.18047931
104Respiratory failure (HP:0002878)2.17309467
105Lethargy (HP:0001254)2.16482438
106Colon cancer (HP:0003003)2.16104327
107Lymphopenia (HP:0001888)2.15834957
108Oral leukoplakia (HP:0002745)2.14830606
109Basal cell carcinoma (HP:0002671)2.14004678
110Pustule (HP:0200039)2.13191949
111Retinal dysplasia (HP:0007973)2.11291365
112Thyroiditis (HP:0100646)2.08867978
113Myositis (HP:0100614)2.08335129
114Abnormality of DNA repair (HP:0003254)2.08300627
115Abnormality of eosinophils (HP:0001879)2.08275551
116Methylmalonic acidemia (HP:0002912)2.08074061
117Hyperglycinuria (HP:0003108)2.07559391
118Abolished electroretinogram (ERG) (HP:0000550)2.07363011
119Medial flaring of the eyebrow (HP:0010747)2.06787901
120Recurrent sinusitis (HP:0011108)2.06548300
121Abnormal delayed hypersensitivity skin test (HP:0002963)2.04296193
122Fatigue (HP:0012378)2.03230349
123Bone marrow hypocellularity (HP:0005528)2.02863904
124Abnormal biliary tract physiology (HP:0012439)2.01874920
125Bile duct proliferation (HP:0001408)2.01874920
126Dicarboxylic aciduria (HP:0003215)2.01602225
127Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01602225
128Leukocytosis (HP:0001974)2.01312734
129Progressive inability to walk (HP:0002505)1.99703212
130Abnormality of the labia minora (HP:0012880)1.98980916
131Progressive muscle weakness (HP:0003323)1.98511700
132Granulocytopenia (HP:0001913)1.98266150
133Attenuation of retinal blood vessels (HP:0007843)1.96665201
134Entropion (HP:0000621)1.95695502
135Carpal bone hypoplasia (HP:0001498)1.95616173
136Abnormality of chromosome stability (HP:0003220)1.95505019
137Sclerocornea (HP:0000647)1.95443861
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.94677965
139Opisthotonus (HP:0002179)1.93076417
140Lissencephaly (HP:0001339)1.90691573
141Abnormality of glycine metabolism (HP:0010895)1.90168594
142Abnormality of serine family amino acid metabolism (HP:0010894)1.90168594
143Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89864369
144Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89864369
145Anencephaly (HP:0002323)1.89308383
146Impulsivity (HP:0100710)1.88896207
147Selective tooth agenesis (HP:0001592)1.88278725
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.88078394
149Abnormality of pyrimidine metabolism (HP:0004353)1.87959947
150Patellar aplasia (HP:0006443)1.87583036
151Chronic sinusitis (HP:0011109)1.86900245
152Personality changes (HP:0000751)1.85276065
153Delayed CNS myelination (HP:0002188)1.84620568
154Concave nail (HP:0001598)1.84484770
155Ketosis (HP:0001946)1.84151591
156Meckel diverticulum (HP:0002245)1.84138233
157Abnormality of the ileum (HP:0001549)1.84021762
158Inability to walk (HP:0002540)1.83988645
159Duplicated collecting system (HP:0000081)1.83569423
160CNS demyelination (HP:0007305)1.83189471
161Nephronophthisis (HP:0000090)1.82817893
162Aplasia/Hypoplasia of the sacrum (HP:0008517)1.82084134
163Acute lymphatic leukemia (HP:0006721)1.80598479
16411 pairs of ribs (HP:0000878)1.80521465
165Clubbing of toes (HP:0100760)1.80296295
166Prolonged bleeding time (HP:0003010)1.80215981
167Squamous cell carcinoma (HP:0002860)1.79975259
168Recurrent skin infections (HP:0001581)1.78602620
169Gait imbalance (HP:0002141)1.77293993
170Leukodystrophy (HP:0002415)1.74686484
171Brushfield spots (HP:0001088)1.74554332
172Severe muscular hypotonia (HP:0006829)1.73877201
173Nephrogenic diabetes insipidus (HP:0009806)1.73827795
174Triphalangeal thumb (HP:0001199)1.73622937
175Congenital primary aphakia (HP:0007707)1.72512236
176Aplasia/Hypoplasia of the patella (HP:0006498)1.71661539
177Aplasia/hypoplasia of the uterus (HP:0008684)1.71074833
178Rib fusion (HP:0000902)1.71070052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.91696845
2VRK23.60702022
3BRSK23.58099951
4WEE13.09169048
5MAP4K12.94709706
6NUAK12.92396427
7NME22.59772865
8BRSK12.36289091
9CDC72.34924289
10MAP4K22.18374462
11ZAP702.09846176
12WNK32.08108458
13BLK2.04902207
14TESK22.03928509
15NEK21.97270176
16TRIM281.96723851
17EIF2AK11.95542943
18ACVR1B1.86657448
19STK101.81449393
20SRPK11.73710270
21JAK31.72372344
22FLT31.71762438
23RPS6KA41.70927823
24KDR1.70299650
25FRK1.69305953
26STK161.65977856
27NME11.65505157
28TXK1.64695111
29SCYL21.63819631
30MARK31.58860453
31DYRK21.56882651
32TLK11.54315556
33RPS6KB21.53109959
34GRK11.47185305
35MAP2K31.44275136
36MKNK11.43480199
37ADRBK21.40490645
38EEF2K1.38872227
39TGFBR11.38284223
40PLK11.38021596
41TYK21.37593265
42TSSK61.37333610
43TBK11.33169199
44PIM21.31469848
45CAMKK21.30775374
46DYRK31.30614516
47EIF2AK31.28975994
48CDK41.28611186
49MAPK131.28104029
50GRK61.26733137
51BCKDK1.24534316
52VRK11.24217211
53IKBKE1.22928414
54KIT1.20282509
55ATR1.19571820
56MKNK21.19510061
57PASK1.18556775
58LRRK21.17885223
59CSNK1G31.17012453
60MAP3K101.16685257
61PINK11.15840121
62INSRR1.12399843
63BMPR1B1.10374166
64TEC1.06809121
65PIM11.06294703
66IKBKB1.05432889
67CHEK21.04635331
68IRAK41.04597499
69AURKB1.03037047
70CDK71.01004715
71MAP2K70.99686937
72PLK40.99295311
73BTK0.98223709
74STK40.98178786
75AURKA0.98034437
76CSNK1G10.95709265
77PLK30.94404568
78NEK10.89571931
79SYK0.87141809
80CSNK1G20.86083519
81CDK80.83953810
82MAP3K80.82970258
83PRKCG0.80235379
84ABL20.79817086
85TTK0.78435274
86DAPK20.78061748
87OXSR10.77291399
88RAF10.75622742
89PDK30.73873560
90PDK40.73873560
91LCK0.73590839
92CCNB10.72626438
93PBK0.69039205
94ARAF0.66845117
95MAP3K110.66240224
96CHEK10.65347973
97CSNK1A1L0.65245668
98TESK10.63965580
99PHKG10.63395577
100PHKG20.63395577
101TNIK0.62971528
102CDK190.62772636
103LYN0.57979405
104CASK0.57639821
105DAPK10.57428683
106CSF1R0.57086945
107ERN10.56878234
108RPS6KA50.56602446
109MAP2K20.56395128
110LIMK10.56145692
111PAK10.54522841
112WNK40.54359827
113TNK20.53897386
114PRKCI0.53840821
115TAF10.52760809
116MAP3K30.52509416
117MAPK150.50846797
118MAPK110.50040778
119IRAK30.49177856
120IRAK10.48269743
121MAPKAPK30.47945804
122CSNK2A20.44804501
123CAMK1D0.44444199
124MST40.43866080
125CSNK2A10.42949847
126MUSK0.42304092
127ZAK0.42087578
128MAPKAPK20.42069925
129ITK0.41647522
130NLK0.41176110
131MELK0.40488444
132PAK40.40431979
133ALK0.40291576
134TAOK10.40078026
135CSNK1A10.38982545
136ADRBK10.38759396
137EIF2AK20.38288460
138RPS6KA60.37901320
139CDK20.37837948
140CHUK0.37392999
141PAK30.36777648
142PRKCE0.36761856
143MAP3K40.36275798
144NEK90.35473144
145TAOK30.32937564
146PRKCQ0.32670121
147PRKCZ0.31937159
148ILK0.31739838
149ATM0.31021400
150PKN10.30815770
151SIK30.30556093

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.14086469
2Ribosome_Homo sapiens_hsa030104.07234339
3Proteasome_Homo sapiens_hsa030503.72244948
4Oxidative phosphorylation_Homo sapiens_hsa001903.56909479
5Mismatch repair_Homo sapiens_hsa034303.43368593
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09840043
7RNA polymerase_Homo sapiens_hsa030203.00709850
8Spliceosome_Homo sapiens_hsa030402.73611664
9Homologous recombination_Homo sapiens_hsa034402.68317695
10Base excision repair_Homo sapiens_hsa034102.64169571
11Primary immunodeficiency_Homo sapiens_hsa053402.60121233
12RNA transport_Homo sapiens_hsa030132.57353535
13Nucleotide excision repair_Homo sapiens_hsa034202.38151955
14Pyrimidine metabolism_Homo sapiens_hsa002402.36449860
15Cell cycle_Homo sapiens_hsa041102.21334538
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.17327633
17One carbon pool by folate_Homo sapiens_hsa006702.08816273
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07559148
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01361688
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90831552
21Antigen processing and presentation_Homo sapiens_hsa046121.84324176
22RNA degradation_Homo sapiens_hsa030181.81775836
23Non-homologous end-joining_Homo sapiens_hsa034501.75167501
24Alzheimers disease_Homo sapiens_hsa050101.75100701
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66499077
26Basal transcription factors_Homo sapiens_hsa030221.60899509
27Fanconi anemia pathway_Homo sapiens_hsa034601.54905622
28Sulfur relay system_Homo sapiens_hsa041221.54804175
29Pentose phosphate pathway_Homo sapiens_hsa000301.39368413
30Butanoate metabolism_Homo sapiens_hsa006501.37095198
31Vitamin B6 metabolism_Homo sapiens_hsa007501.37059925
32p53 signaling pathway_Homo sapiens_hsa041151.36587009
33Fatty acid elongation_Homo sapiens_hsa000621.36414131
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33967622
35Herpes simplex infection_Homo sapiens_hsa051681.25329013
36Peroxisome_Homo sapiens_hsa041461.24289624
37Epstein-Barr virus infection_Homo sapiens_hsa051691.23495871
38Purine metabolism_Homo sapiens_hsa002301.21686180
39mRNA surveillance pathway_Homo sapiens_hsa030151.18993871
40Measles_Homo sapiens_hsa051621.18702474
41Sulfur metabolism_Homo sapiens_hsa009201.17403576
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09484781
43Collecting duct acid secretion_Homo sapiens_hsa049661.09408425
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.08588207
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08472891
46Phototransduction_Homo sapiens_hsa047441.07127084
47Folate biosynthesis_Homo sapiens_hsa007901.04235171
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04013505
49Propanoate metabolism_Homo sapiens_hsa006401.02660625
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97060398
51Cardiac muscle contraction_Homo sapiens_hsa042600.93099979
52Viral carcinogenesis_Homo sapiens_hsa052030.89313908
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.88196710
54Tryptophan metabolism_Homo sapiens_hsa003800.87934366
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87252885
56Pyruvate metabolism_Homo sapiens_hsa006200.86406428
57Shigellosis_Homo sapiens_hsa051310.86095331
58Hematopoietic cell lineage_Homo sapiens_hsa046400.84561506
59Apoptosis_Homo sapiens_hsa042100.81429991
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80688629
61T cell receptor signaling pathway_Homo sapiens_hsa046600.80682617
62Systemic lupus erythematosus_Homo sapiens_hsa053220.79795383
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.79496282
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.79433990
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79117476
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78828176
67B cell receptor signaling pathway_Homo sapiens_hsa046620.78304080
68Acute myeloid leukemia_Homo sapiens_hsa052210.75341479
69Protein export_Homo sapiens_hsa030600.74822244
70Linoleic acid metabolism_Homo sapiens_hsa005910.73828792
71Steroid biosynthesis_Homo sapiens_hsa001000.73764547
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.71261857
73Oocyte meiosis_Homo sapiens_hsa041140.70195219
74Selenocompound metabolism_Homo sapiens_hsa004500.69468348
75Leishmaniasis_Homo sapiens_hsa051400.68849378
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.68409181
77HTLV-I infection_Homo sapiens_hsa051660.68136702
78Legionellosis_Homo sapiens_hsa051340.67895706
79Biosynthesis of amino acids_Homo sapiens_hsa012300.67579311
80Nitrogen metabolism_Homo sapiens_hsa009100.66937331
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66631288
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65900461
83Arginine and proline metabolism_Homo sapiens_hsa003300.64407954
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.62209402
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61351281
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61121769
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60971018
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60749265
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59205030
90Arachidonic acid metabolism_Homo sapiens_hsa005900.56707369
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56000775
92Thyroid cancer_Homo sapiens_hsa052160.54724825
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52755051
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.51654444
95Ether lipid metabolism_Homo sapiens_hsa005650.51104262
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51044256
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50948935
98Hepatitis B_Homo sapiens_hsa051610.50921699
99Allograft rejection_Homo sapiens_hsa053300.48118910
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47254924
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46357704
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46175052
103Carbon metabolism_Homo sapiens_hsa012000.44809571
104Influenza A_Homo sapiens_hsa051640.44273152
105Caffeine metabolism_Homo sapiens_hsa002320.42730723
106Parkinsons disease_Homo sapiens_hsa050120.42308181
107Huntingtons disease_Homo sapiens_hsa050160.41920132
108Regulation of autophagy_Homo sapiens_hsa041400.41760776
109Chemical carcinogenesis_Homo sapiens_hsa052040.40690093
110N-Glycan biosynthesis_Homo sapiens_hsa005100.40269546
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39249807
112Fatty acid metabolism_Homo sapiens_hsa012120.37577236
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36337567
114Chronic myeloid leukemia_Homo sapiens_hsa052200.36271608
115Nicotine addiction_Homo sapiens_hsa050330.35953937
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34986205
117Galactose metabolism_Homo sapiens_hsa000520.32055318
118Fructose and mannose metabolism_Homo sapiens_hsa000510.31561496
119Viral myocarditis_Homo sapiens_hsa054160.31538822
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31258588
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30775363
122Graft-versus-host disease_Homo sapiens_hsa053320.30476843
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.30378190
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29956023
125Osteoclast differentiation_Homo sapiens_hsa043800.29640740
126Olfactory transduction_Homo sapiens_hsa047400.29003964
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28696180
128beta-Alanine metabolism_Homo sapiens_hsa004100.28408776
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27573687
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27294799
131Glutathione metabolism_Homo sapiens_hsa004800.26449620
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26106542
133Fatty acid degradation_Homo sapiens_hsa000710.25831898
134Tuberculosis_Homo sapiens_hsa051520.25519976
135Bladder cancer_Homo sapiens_hsa052190.25031426
136Asthma_Homo sapiens_hsa053100.25018216
137Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24477532
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24475391
139Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24252734
140Metabolic pathways_Homo sapiens_hsa011000.23370202
141Synaptic vesicle cycle_Homo sapiens_hsa047210.22564031
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21799993
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21557707
144Colorectal cancer_Homo sapiens_hsa052100.19348665
145Non-small cell lung cancer_Homo sapiens_hsa052230.18844409
146Rheumatoid arthritis_Homo sapiens_hsa053230.17933084
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16587641
148Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.16253211
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.16036971

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