ALG12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.72929888
2Golgi transport vesicle coating (GO:0048200)5.72929888
3signal peptide processing (GO:0006465)4.15550008
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.04929120
5UDP-N-acetylglucosamine metabolic process (GO:0006047)3.87722561
6COPII vesicle coating (GO:0048208)3.84865153
7DNA deamination (GO:0045006)3.77339091
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.64391806
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64391806
10proline biosynthetic process (GO:0006561)3.62554736
11negative regulation of cell size (GO:0045792)3.55240005
12folic acid-containing compound biosynthetic process (GO:0009396)3.54870940
13pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.52063257
14UMP biosynthetic process (GO:0006222)3.52063257
15pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.52063257
16UMP metabolic process (GO:0046049)3.52063257
17GDP-mannose metabolic process (GO:0019673)3.44772757
18positive regulation of nuclease activity (GO:0032075)3.42374662
19urea cycle (GO:0000050)3.41742931
20pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.40359215
21activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.38462469
22antigen processing and presentation of endogenous antigen (GO:0019883)3.37382819
23pinocytosis (GO:0006907)3.36962682
24protein retention in ER lumen (GO:0006621)3.36705812
25chaperone mediated protein folding requiring cofactor (GO:0051085)3.32707528
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.29788483
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29477999
28folic acid metabolic process (GO:0046655)3.28906576
29urea metabolic process (GO:0019627)3.26278839
30* protein N-linked glycosylation via asparagine (GO:0018279)3.26032305
31regulation of nuclease activity (GO:0032069)3.23740499
32* peptidyl-asparagine modification (GO:0018196)3.22925366
33nucleobase biosynthetic process (GO:0046112)3.20475617
34barbed-end actin filament capping (GO:0051016)3.19210584
35pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.17724151
36negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14426539
37regulation of cholesterol biosynthetic process (GO:0045540)3.13928847
38positive regulation by symbiont of host defense response (GO:0052509)3.11458120
39modulation by symbiont of host defense response (GO:0052031)3.11458120
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11458120
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11458120
42positive regulation by organism of defense response of other organism involved in symbiotic interact3.11458120
43modulation by symbiont of host immune response (GO:0052553)3.11458120
44purine nucleobase biosynthetic process (GO:0009113)3.10612825
45apoptotic process involved in morphogenesis (GO:0060561)3.09629843
46positive regulation of Cdc42 GTPase activity (GO:0043089)3.07070421
47NADH metabolic process (GO:0006734)3.06321159
48protein maturation by protein folding (GO:0022417)3.05014291
49L-phenylalanine metabolic process (GO:0006558)3.01869246
50erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.01869246
51nucleoside salvage (GO:0043174)3.00427049
52nucleotide-sugar biosynthetic process (GO:0009226)3.00104689
53endoplasmic reticulum unfolded protein response (GO:0030968)2.99888614
54nitrogen cycle metabolic process (GO:0071941)2.96838032
55cellular response to unfolded protein (GO:0034620)2.95707643
56deoxyribose phosphate biosynthetic process (GO:0046385)2.94127436
572-deoxyribonucleotide biosynthetic process (GO:0009265)2.94127436
58protein carboxylation (GO:0018214)2.93869389
59peptidyl-glutamic acid carboxylation (GO:0017187)2.93869389
60* protein N-linked glycosylation (GO:0006487)2.92136741
61regulation of cholesterol metabolic process (GO:0090181)2.91617615
624-hydroxyproline metabolic process (GO:0019471)2.90920267
63cellular response to topologically incorrect protein (GO:0035967)2.89150355
64pentose-phosphate shunt (GO:0006098)2.88271789
65UV protection (GO:0009650)2.87884528
66pteridine-containing compound biosynthetic process (GO:0042559)2.86785833
67positive regulation of lipoprotein lipase activity (GO:0051006)2.85082886
68positive regulation of triglyceride lipase activity (GO:0061365)2.85082886
69peptide catabolic process (GO:0043171)2.84936768
70tetrahydrofolate metabolic process (GO:0046653)2.82461740
71cellular response to interleukin-4 (GO:0071353)2.81064339
72negative regulation of innate immune response (GO:0045824)2.79375674
73ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.78863163
74negative regulation of erythrocyte differentiation (GO:0045647)2.78862327
75methionine biosynthetic process (GO:0009086)2.78842716
76protein localization to endosome (GO:0036010)2.78596396
77basement membrane organization (GO:0071711)2.78299043
78positive regulation of gamma-delta T cell activation (GO:0046645)2.78036328
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76883906
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.76883906
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.75766021
82L-phenylalanine catabolic process (GO:0006559)2.75766021
83ER-nucleus signaling pathway (GO:0006984)2.75453687
84negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.75371909
85negative regulation of cell killing (GO:0031342)2.75371909
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.75358696
87proline metabolic process (GO:0006560)2.74884231
88glucose catabolic process (GO:0006007)2.74076142
89mannose metabolic process (GO:0006013)2.69032636
90nucleoside diphosphate biosynthetic process (GO:0009133)2.68095514
91antigen processing and presentation via MHC class Ib (GO:0002475)2.67834935
92histone-serine phosphorylation (GO:0035404)2.64944064
93negative regulation of necroptotic process (GO:0060546)2.63900669
94misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.63014331
95deoxyribonucleotide biosynthetic process (GO:0009263)2.62581353
96regulation of cholesterol homeostasis (GO:2000188)2.62517694
97NADPH regeneration (GO:0006740)2.60605948
98sulfur amino acid biosynthetic process (GO:0000097)2.60323481
993-UTR-mediated mRNA stabilization (GO:0070935)2.58305229
100cellular response to zinc ion (GO:0071294)2.58125954
101regulation of mammary gland epithelial cell proliferation (GO:0033599)2.58079428
102tryptophan metabolic process (GO:0006568)2.58023830
103* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.57541134
104protein autoprocessing (GO:0016540)2.57392203
105one-carbon metabolic process (GO:0006730)2.57279781
106regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57266591
107positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.56965583
108IMP biosynthetic process (GO:0006188)2.56496196
109spliceosomal tri-snRNP complex assembly (GO:0000244)2.56155356
110response to laminar fluid shear stress (GO:0034616)2.55122449
111regulation of superoxide anion generation (GO:0032928)2.55110604
112pyrimidine nucleoside salvage (GO:0043097)2.55082129
113pyrimidine-containing compound salvage (GO:0008655)2.55082129
114phosphorylated carbohydrate dephosphorylation (GO:0046838)2.55026261
115inositol phosphate dephosphorylation (GO:0046855)2.55026261
116amyloid precursor protein catabolic process (GO:0042987)2.54100277
117telomere maintenance via semi-conservative replication (GO:0032201)2.53912236
118nucleotide-sugar metabolic process (GO:0009225)2.53876769
119ER overload response (GO:0006983)2.53391168
120purine deoxyribonucleotide catabolic process (GO:0009155)2.52941052
121killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.52055057
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.52055057
123glycoside metabolic process (GO:0016137)2.50788744
124vesicle coating (GO:0006901)2.49894273
125folic acid-containing compound metabolic process (GO:0006760)2.49472727
126intracellular estrogen receptor signaling pathway (GO:0030520)2.48974695
127pentose metabolic process (GO:0019321)2.48418331
128phospholipid efflux (GO:0033700)2.45912697
129NIK/NF-kappaB signaling (GO:0038061)2.45628736
130positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.45291679
131negative regulation of phagocytosis (GO:0050765)2.45119029
132homocysteine metabolic process (GO:0050667)2.44953702
133peptidyl-arginine omega-N-methylation (GO:0035247)2.43514490
134S-adenosylmethionine metabolic process (GO:0046500)2.43071640
135snRNA metabolic process (GO:0016073)2.42946218
136alpha-linolenic acid metabolic process (GO:0036109)2.42720503
137modulation by virus of host process (GO:0019054)2.42701583
138purine-containing compound salvage (GO:0043101)2.42553673
139negative regulation of cAMP-mediated signaling (GO:0043951)2.42538567
140glutamine family amino acid biosynthetic process (GO:0009084)2.42258557
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.41640073
142metallo-sulfur cluster assembly (GO:0031163)2.40960965
143iron-sulfur cluster assembly (GO:0016226)2.40960965
144cellular metabolic compound salvage (GO:0043094)2.39737338
145pteridine-containing compound metabolic process (GO:0042558)2.39704360
146oxaloacetate metabolic process (GO:0006107)2.38820629
147regulation of necroptotic process (GO:0060544)2.38795835
148dosage compensation (GO:0007549)2.38733563
149methionine metabolic process (GO:0006555)2.36886745
150DNA strand elongation involved in DNA replication (GO:0006271)2.36494837
151modulation by symbiont of host cellular process (GO:0044068)2.36238473
152response to interleukin-4 (GO:0070670)2.35824756
153aspartate family amino acid biosynthetic process (GO:0009067)2.35429564
154formation of translation preinitiation complex (GO:0001731)2.34435989
155galactose catabolic process (GO:0019388)2.33399373
156tricarboxylic acid metabolic process (GO:0072350)2.33230535
157regulation of triglyceride catabolic process (GO:0010896)2.33170664
158negative regulation of viral release from host cell (GO:1902187)2.33139151
159regulation of gamma-delta T cell differentiation (GO:0045586)2.32508818
160thymic T cell selection (GO:0045061)2.31456473
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.31316051
162negative regulation of fibrinolysis (GO:0051918)2.28892888
163L-serine metabolic process (GO:0006563)2.28341407
164semaphorin-plexin signaling pathway (GO:0071526)2.27976061
165histone H4 deacetylation (GO:0070933)2.27228740
166cellular response to virus (GO:0098586)2.25476974
167epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24585246
168snRNA processing (GO:0016180)2.23846090
169maternal placenta development (GO:0001893)2.23248203
170glucose 6-phosphate metabolic process (GO:0051156)2.22887239
171regulation of translational fidelity (GO:0006450)2.22585406
172monosaccharide biosynthetic process (GO:0046364)2.22575432
173amino sugar catabolic process (GO:0046348)2.21412434
174stress fiber assembly (GO:0043149)2.19980499
175regulation of cholesterol esterification (GO:0010872)2.19937368
176regulation of glucose import in response to insulin stimulus (GO:2001273)2.19132985
177positive regulation of receptor biosynthetic process (GO:0010870)2.18950489
178maintenance of protein localization in organelle (GO:0072595)2.18806692
179regulation of necrotic cell death (GO:0010939)2.18619394
180regulation of extracellular matrix disassembly (GO:0010715)2.18013095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.90297181
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.22197334
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81192643
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.65505267
5MYC_22102868_ChIP-Seq_BL_Human2.65254355
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59973171
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52461281
8SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.44335608
9LXR_22292898_ChIP-Seq_THP-1_Human2.44203779
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43928183
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.33374645
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.28665268
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18968231
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16098008
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.11971112
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10874182
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09412892
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07045003
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.05792683
20GATA1_22025678_ChIP-Seq_K562_Human2.03151211
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02466205
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99343749
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94230037
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93028689
25RACK7_27058665_Chip-Seq_MCF-7_Human1.92334203
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.92309882
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89453867
28VDR_21846776_ChIP-Seq_THP-1_Human1.88553045
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.87149428
30CIITA_25753668_ChIP-Seq_RAJI_Human1.86998234
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86396595
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83854402
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.81993731
34* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81232727
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.79231699
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.78385399
37SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.77871732
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76870758
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76233627
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76030971
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70473010
42* GABP_19822575_ChIP-Seq_HepG2_Human1.69855592
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.69061226
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.67549068
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66905909
46ERG_20887958_ChIP-Seq_HPC-7_Mouse1.65458349
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64396392
48FOXP3_21729870_ChIP-Seq_TREG_Human1.64324608
49TFEB_21752829_ChIP-Seq_HELA_Human1.62763165
50SPI1_23547873_ChIP-Seq_NB4_Human1.62711978
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.61231731
52* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60353194
53VDR_23849224_ChIP-Seq_CD4+_Human1.59385442
54KDM2B_26808549_Chip-Seq_DND41_Human1.56370213
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53861810
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53700016
57P68_20966046_ChIP-Seq_HELA_Human1.52665243
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52101601
59CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49706802
60MYC_19030024_ChIP-ChIP_MESCs_Mouse1.48701259
61DCP1A_22483619_ChIP-Seq_HELA_Human1.46325513
62MYB_26560356_Chip-Seq_TH1_Human1.45151693
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44315196
64SCL_19346495_ChIP-Seq_HPC-7_Human1.43814278
65MAF_26560356_Chip-Seq_TH2_Human1.43407423
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43022700
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.42470179
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40344064
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39840426
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38990405
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38104300
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.37872995
73KDM5A_27292631_Chip-Seq_BREAST_Human1.37835533
74FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35422204
75VDR_24763502_ChIP-Seq_THP-1_Human1.35327604
76ZNF263_19887448_ChIP-Seq_K562_Human1.35285430
77ELF1_20517297_ChIP-Seq_JURKAT_Human1.35056930
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34634171
79NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33682369
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33619721
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33177840
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32602017
83MAF_26560356_Chip-Seq_TH1_Human1.32564171
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32400630
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32130708
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31425564
87UTX_26944678_Chip-Seq_JUKART_Human1.31076068
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30855583
89MYB_26560356_Chip-Seq_TH2_Human1.30805580
90XRN2_22483619_ChIP-Seq_HELA_Human1.29887661
91BCOR_27268052_Chip-Seq_Bcells_Human1.28640945
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.28634791
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28065963
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28061674
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28051823
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27166185
97HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26685011
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.26236621
99BCL6_27268052_Chip-Seq_Bcells_Human1.25258411
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22924712
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22571359
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20675402
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20508619
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20410253
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20310504
106PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19518418
107* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19104436
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18719311
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17576752
110SMC4_20622854_ChIP-Seq_HELA_Human1.16961356
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16513054
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16443459
113LXR_22158963_ChIP-Seq_LIVER_Mouse1.15806681
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15762657
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15258304
116* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13966228
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13863869
118GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13278930
119MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13154751
120RUNX1_22412390_ChIP-Seq_EML_Mouse1.13070417
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12758426
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12695863
123ATF3_27146783_Chip-Seq_COLON_Human1.12319975
124STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11999932
125* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10286718
126RARB_24833708_ChIP-Seq_LIVER_Mouse1.09666473
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09647934
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09188555
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09110550
130NCOR1_26117541_ChIP-Seq_K562_Human1.08491124
131FOXM1_23109430_ChIP-Seq_U2OS_Human1.07974877
132TCF7_22412390_ChIP-Seq_EML_Mouse1.07075500
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06924448
134SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06085189
135NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06071917
136TP53_22127205_ChIP-Seq_IMR90_Human1.05402686
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04463352
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04334903
139STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03030002
140* ETS1_21867929_ChIP-Seq_TH2_Mouse1.02950647
141NOTCH1_21737748_ChIP-Seq_TLL_Human1.02769346
142PHF8_20622854_ChIP-Seq_HELA_Human1.02546279
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01522061
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01382988
145RARA_24833708_ChIP-Seq_LIVER_Mouse1.01226020
146CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01124376
147CTCF_21964334_Chip-Seq_Bcells_Human1.01072666
148IRF8_27001747_Chip-Seq_BMDM_Mouse0.99833513
149RUNX_20019798_ChIP-Seq_JUKART_Human0.99624936
150SPI1_23127762_ChIP-Seq_K562_Human0.97476278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.72660618
2MP0008260_abnormal_autophagy3.28853751
3MP0005451_abnormal_body_composition3.06516284
4MP0003693_abnormal_embryo_hatching2.65681287
5MP0002396_abnormal_hematopoietic_system2.57348586
6MP0002139_abnormal_hepatobiliary_system2.49807500
7MP0005365_abnormal_bile_salt2.36196053
8MP0001849_ear_inflammation2.28027953
9MP0004858_abnormal_nervous_system2.18293175
10MP0004264_abnormal_extraembryonic_tissu2.14820353
11MP0000685_abnormal_immune_system2.11771964
12MP0005671_abnormal_response_to2.06195912
13MP0002877_abnormal_melanocyte_morpholog2.05954631
14MP0003763_abnormal_thymus_physiology2.05652207
15MP0001835_abnormal_antigen_presentation1.99198904
16MP0005058_abnormal_lysosome_morphology1.91702931
17MP0009333_abnormal_splenocyte_physiolog1.86904838
18MP0005360_urolithiasis1.85037939
19MP0009840_abnormal_foam_cell1.84589141
20MP0010386_abnormal_urinary_bladder1.80680696
21MP0000013_abnormal_adipose_tissue1.79233775
22MP0001800_abnormal_humoral_immune1.74214598
23MP0010094_abnormal_chromosome_stability1.69583723
24MP0005076_abnormal_cell_differentiation1.69451765
25MP0008057_abnormal_DNA_replication1.68562262
26MP0003436_decreased_susceptibility_to1.68537973
27MP0008438_abnormal_cutaneous_collagen1.67382213
28MP0001873_stomach_inflammation1.66982357
29MP0003566_abnormal_cell_adhesion1.66347187
30MP0000678_abnormal_parathyroid_gland1.66082568
31MP0003656_abnormal_erythrocyte_physiolo1.65573255
32MP0004808_abnormal_hematopoietic_stem1.60545894
33MP0002398_abnormal_bone_marrow1.59973927
34MP0008007_abnormal_cellular_replicative1.59230688
35MP0005387_immune_system_phenotype1.58344391
36MP0001790_abnormal_immune_system1.58344391
37MP0005257_abnormal_intraocular_pressure1.54483117
38MP0009278_abnormal_bone_marrow1.53189676
39MP0004947_skin_inflammation1.52847941
40MP0003172_abnormal_lysosome_physiology1.50886067
41MP0003868_abnormal_feces_composition1.50713134
42MP0000689_abnormal_spleen_morphology1.48422604
43MP0005220_abnormal_exocrine_pancreas1.47761058
44MP0003300_gastrointestinal_ulcer1.46548816
45MP0002452_abnormal_antigen_presenting1.46264489
46MP0003111_abnormal_nucleus_morphology1.46087098
47MP0008058_abnormal_DNA_repair1.44438849
48MP0003806_abnormal_nucleotide_metabolis1.43798625
49MP0004233_abnormal_muscle_weight1.43297774
50MP0002693_abnormal_pancreas_physiology1.41872762
51MP0002723_abnormal_immune_serum1.41363406
52MP0010234_abnormal_vibrissa_follicle1.41230052
53MP0009697_abnormal_copulation1.40500555
54MP0001944_abnormal_pancreas_morphology1.40283108
55MP0003077_abnormal_cell_cycle1.37942689
56MP0002722_abnormal_immune_system1.37491146
57MP0002420_abnormal_adaptive_immunity1.37433743
58MP0005670_abnormal_white_adipose1.37153430
59MP0001819_abnormal_immune_cell1.35294766
60MP0000609_abnormal_liver_physiology1.35195369
61MP0004185_abnormal_adipocyte_glucose1.33938495
62MP0003453_abnormal_keratinocyte_physiol1.33779651
63MP0004381_abnormal_hair_follicle1.33422095
64MP0005501_abnormal_skin_physiology1.33132273
65MP0005025_abnormal_response_to1.32365702
66MP0002796_impaired_skin_barrier1.32294537
67MP0000716_abnormal_immune_system1.30849440
68MP0009643_abnormal_urine_homeostasis1.30453614
69MP0003943_abnormal_hepatobiliary_system1.29215062
70MP0004957_abnormal_blastocyst_morpholog1.28714132
71MP0002419_abnormal_innate_immunity1.26791430
72MP0001986_abnormal_taste_sensitivity1.26530824
73MP0002429_abnormal_blood_cell1.25377125
74MP0005000_abnormal_immune_tolerance1.25319991
75MP0002254_reproductive_system_inflammat1.24748277
76MP0001845_abnormal_inflammatory_respons1.24050122
77MP0010329_abnormal_lipoprotein_level1.22998881
78MP0000703_abnormal_thymus_morphology1.22185411
79MP0002837_dystrophic_cardiac_calcinosis1.20939734
80MP0005085_abnormal_gallbladder_physiolo1.19678792
81MP0001764_abnormal_homeostasis1.19450677
82MP0001545_abnormal_hematopoietic_system1.18587641
83MP0005397_hematopoietic_system_phenotyp1.18587641
84MP0000537_abnormal_urethra_morphology1.18335947
85MP0000490_abnormal_crypts_of1.17350032
86MP0000003_abnormal_adipose_tissue1.17274059
87MP0002060_abnormal_skin_morphology1.16060423
88MP0005464_abnormal_platelet_physiology1.15843689
89MP0003279_aneurysm1.15532218
90MP0003252_abnormal_bile_duct1.15404313
91MP0008469_abnormal_protein_level1.14591090
92MP0000465_gastrointestinal_hemorrhage1.12420151
93MP0005332_abnormal_amino_acid1.12142943
94MP0001915_intracranial_hemorrhage1.12138483
95MP0001666_abnormal_nutrient_absorption1.10574093
96MP0004272_abnormal_basement_membrane1.08962403
97MP0002138_abnormal_hepatobiliary_system1.08911961
98MP0005319_abnormal_enzyme/_coenzyme1.08096477
99MP0010155_abnormal_intestine_physiology1.07737676
100MP0000598_abnormal_liver_morphology1.06957443
101MP0001958_emphysema1.06174109
102MP0008875_abnormal_xenobiotic_pharmacok1.05186882
103MP0003091_abnormal_cell_migration1.05126230
104MP0009785_altered_susceptibility_to1.05092871
105MP0006054_spinal_hemorrhage1.04072711
106MP0003191_abnormal_cellular_cholesterol1.03037969
107MP0002166_altered_tumor_susceptibility1.02945036
108MP0001661_extended_life_span1.02702437
109MP0005023_abnormal_wound_healing1.02663935
110MP0000015_abnormal_ear_pigmentation1.01855485
111MP0000358_abnormal_cell_content/1.01724736
112MP0003195_calcinosis1.01512985
113MP0002998_abnormal_bone_remodeling1.01038862
114MP0003303_peritoneal_inflammation0.99823918
115MP0005375_adipose_tissue_phenotype0.99463672
116MP0000681_abnormal_thyroid_gland0.98997153
117MP0003866_abnormal_defecation0.97996610
118MP0009931_abnormal_skin_appearance0.97443748
119MP0005666_abnormal_adipose_tissue0.96144665
120MP0001730_embryonic_growth_arrest0.94741839
121MP0009384_cardiac_valve_regurgitation0.94435023
122MP0002933_joint_inflammation0.94427322
123MP0002019_abnormal_tumor_incidence0.92413062
124MP0000858_altered_metastatic_potential0.92046337
125MP0005636_abnormal_mineral_homeostasis0.89819079
126MP0001756_abnormal_urination0.89019481
127MP0001765_abnormal_ion_homeostasis0.88958607
128MP0002078_abnormal_glucose_homeostasis0.88867952
129MP0000751_myopathy0.88509161
130MP0001216_abnormal_epidermal_layer0.87976623
131MP0010030_abnormal_orbit_morphology0.86598300
132MP0003705_abnormal_hypodermis_morpholog0.86406943
133MP0010307_abnormal_tumor_latency0.86206650
134MP0005621_abnormal_cell_physiology0.84969926
135MP0008877_abnormal_DNA_methylation0.82734549
136MP0005083_abnormal_biliary_tract0.81903094
137MP0000313_abnormal_cell_death0.80278873
138MP0002249_abnormal_larynx_morphology0.79995223
139MP0002089_abnormal_postnatal_growth/wei0.79354681
140MP0006036_abnormal_mitochondrial_physio0.78389815
141MP0001533_abnormal_skeleton_physiology0.78291158
142MP0005075_abnormal_melanosome_morpholog0.77595948
143MP0005584_abnormal_enzyme/coenzyme_acti0.77356192
144MP0005390_skeleton_phenotype0.77199372
145MP0006082_CNS_inflammation0.76550749
146MP0004782_abnormal_surfactant_physiolog0.76453828
147MP0002405_respiratory_system_inflammati0.76227481

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)4.39036938
2Deep venous thrombosis (HP:0002625)3.46159211
3Aplastic anemia (HP:0001915)3.43907659
4Birth length less than 3rd percentile (HP:0003561)3.37113905
5Thrombocytosis (HP:0001894)3.30386630
6Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.24090969
7Abnormal protein N-linked glycosylation (HP:0012347)3.24090969
8Abnormal protein glycosylation (HP:0012346)3.24090969
9Abnormal glycosylation (HP:0012345)3.24090969
10Abnormality of the common coagulation pathway (HP:0010990)3.16002327
11Vertebral compression fractures (HP:0002953)3.00182845
12Type I transferrin isoform profile (HP:0003642)2.98761300
13Abnormality of aromatic amino acid family metabolism (HP:0004338)2.96991526
14Reduced antithrombin III activity (HP:0001976)2.81327621
15Thin bony cortex (HP:0002753)2.80973147
16Hemorrhage of the eye (HP:0011885)2.78885245
17Cholecystitis (HP:0001082)2.77465771
18Abnormal gallbladder physiology (HP:0012438)2.77465771
19Cerebral aneurysm (HP:0004944)2.73613727
20Premature rupture of membranes (HP:0001788)2.67577111
21Eczematoid dermatitis (HP:0000976)2.66234118
22Hyperglycemia (HP:0003074)2.65507042
23Short nail (HP:0001799)2.62515648
24Abnormality of T cell physiology (HP:0011840)2.58800495
25Cervical subluxation (HP:0003308)2.57255453
26Broad face (HP:0000283)2.55744343
27Protrusio acetabuli (HP:0003179)2.55383867
28Abnormality of liposaccharide metabolism (HP:0010968)2.50675609
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.50675609
30Abnormality of glycolipid metabolism (HP:0010969)2.50675609
31Cerebellar dysplasia (HP:0007033)2.48796231
32Nonimmune hydrops fetalis (HP:0001790)2.48010417
33Recurrent viral infections (HP:0004429)2.47767837
34Insulin resistance (HP:0000855)2.47632229
35Long palpebral fissure (HP:0000637)2.43267692
36Recurrent bronchitis (HP:0002837)2.43215281
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.41681393
38Increased connective tissue (HP:0009025)2.41407001
39Abnormality of endocrine pancreas physiology (HP:0012093)2.40298787
40Abnormality of the pancreatic islet cells (HP:0006476)2.40298787
41Prolonged partial thromboplastin time (HP:0003645)2.39977009
42Retinal atrophy (HP:0001105)2.39570050
43Insulin-resistant diabetes mellitus (HP:0000831)2.39170282
44Hyperacusis (HP:0010780)2.36204416
45IgM deficiency (HP:0002850)2.36056920
46Joint hemorrhage (HP:0005261)2.34769761
47Loss of speech (HP:0002371)2.34523423
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.33789671
49Gout (HP:0001997)2.33544806
50J-shaped sella turcica (HP:0002680)2.32447964
51Homocystinuria (HP:0002156)2.31803232
52Abnormality of homocysteine metabolism (HP:0010919)2.31803232
53Broad distal phalanx of finger (HP:0009836)2.30113749
54Systemic lupus erythematosus (HP:0002725)2.27513058
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27418548
56Abnormality of polysaccharide metabolism (HP:0011012)2.27418548
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27418548
58Ulnar bowing (HP:0003031)2.25944556
59Recurrent gram-negative bacterial infections (HP:0005420)2.25816799
60Thoracic kyphosis (HP:0002942)2.25612409
61Generalized aminoaciduria (HP:0002909)2.25427712
62Bundle branch block (HP:0011710)2.25063162
63Increased cerebral lipofuscin (HP:0011813)2.24450998
64Achilles tendon contracture (HP:0001771)2.23969497
65Hypoglycemic coma (HP:0001325)2.23940531
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.23060313
67Hypoplasia of the thymus (HP:0000778)2.22071223
68Mucopolysacchariduria (HP:0008155)2.21483967
69Urinary glycosaminoglycan excretion (HP:0003541)2.21483967
70Malnutrition (HP:0004395)2.20258444
71Joint stiffness (HP:0001387)2.18509574
72Vacuolated lymphocytes (HP:0001922)2.18282961
73Blue sclerae (HP:0000592)2.16881685
74Dysostosis multiplex (HP:0000943)2.16225814
75Abnormality of pyrimidine metabolism (HP:0004353)2.15812296
76Abnormality of the Achilles tendon (HP:0005109)2.15641342
77Beaking of vertebral bodies (HP:0004568)2.15047273
78Abnormality of the thoracic spine (HP:0100711)2.13866196
79Disproportionate tall stature (HP:0001519)2.13790578
80Elevated alkaline phosphatase (HP:0003155)2.13602927
81Gastrointestinal stroma tumor (HP:0100723)2.13450983
82Abnormality of sulfur amino acid metabolism (HP:0004339)2.13344743
83Abnormality of T cells (HP:0002843)2.13103650
84Late onset (HP:0003584)2.12636382
85Abnormality of B cell number (HP:0010975)2.12447785
86B lymphocytopenia (HP:0010976)2.12447785
87Abnormality of macrophages (HP:0004311)2.10718640
8811 pairs of ribs (HP:0000878)2.10520562
89Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10256145
90Colitis (HP:0002583)2.10152810
91Abnormality of the distal phalanges of the toes (HP:0010182)2.08978317
92Testicular atrophy (HP:0000029)2.07806218
93Ketoacidosis (HP:0001993)2.07169463
94Hypertriglyceridemia (HP:0002155)2.07016807
95Abnormality of alkaline phosphatase activity (HP:0004379)2.06732032
96Hypothermia (HP:0002045)2.06032028
97Abnormal enzyme/coenzyme activity (HP:0012379)2.05323385
98Selective tooth agenesis (HP:0001592)2.03117410
99Ketosis (HP:0001946)2.02526398
100Entropion (HP:0000621)2.02521874
101Distal lower limb amyotrophy (HP:0008944)2.00657248
102Distal lower limb muscle weakness (HP:0009053)2.00653848
103Amaurosis fugax (HP:0100576)2.00478147
104Spontaneous hematomas (HP:0007420)2.00475984
105Hyperinsulinemic hypoglycemia (HP:0000825)1.99496602
106Type II lissencephaly (HP:0007260)1.98180192
107Decreased circulating renin level (HP:0003351)1.97657487
108Progressive muscle weakness (HP:0003323)1.97413629
109Distal upper limb amyotrophy (HP:0007149)1.97172188
110Upper limb amyotrophy (HP:0009129)1.97172188
111Neutropenia (HP:0001875)1.96989259
112Panhypogammaglobulinemia (HP:0003139)1.96411929
113Gastrointestinal dysmotility (HP:0002579)1.95725088
114Spondylolisthesis (HP:0003302)1.95722472
115Atrophic scars (HP:0001075)1.94197356
116Premature skin wrinkling (HP:0100678)1.94034676
117Flat acetabular roof (HP:0003180)1.94011272
118Ragged-red muscle fibers (HP:0003200)1.93025296
119Pancreatic islet-cell hyperplasia (HP:0004510)1.92125000
120Abnormal platelet function (HP:0011869)1.91940488
121Impaired platelet aggregation (HP:0003540)1.91940488
122Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89875602
123Abnormality of complement system (HP:0005339)1.88591121
124Stridor (HP:0010307)1.87999205
125Hepatosplenomegaly (HP:0001433)1.85983083
126Abnormality of alanine metabolism (HP:0010916)1.85279448
127Hyperalaninemia (HP:0003348)1.85279448
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85279448
129Radial bowing (HP:0002986)1.85048075
130Toxemia of pregnancy (HP:0100603)1.84133630
131Recurrent abscess formation (HP:0002722)1.84040774
132Increased serum ferritin (HP:0003281)1.83919417
133Short clavicles (HP:0000894)1.83535940
134Rough bone trabeculation (HP:0100670)1.83405138
135Recurrent fungal infections (HP:0002841)1.83154201
136Agnosia (HP:0010524)1.82906495
137Epistaxis (HP:0000421)1.82842988
138Hypoglycemic seizures (HP:0002173)1.82699365
139Dysautonomia (HP:0002459)1.82140329
140Xanthomatosis (HP:0000991)1.81966017
141Gastrointestinal inflammation (HP:0004386)1.80688302
142Abnormal foot bone ossification (HP:0010675)1.80537406
143Abnormality of monocarboxylic acid metabolism (HP:0010996)1.79621610
144Agammaglobulinemia (HP:0004432)1.77428876
145Large for gestational age (HP:0001520)1.76872826
146Abnormality of purine metabolism (HP:0004352)1.76767618
147Dilatation of the ascending aorta (HP:0005111)1.75986944
148Prominent metopic ridge (HP:0005487)1.75744893
149Recurrent bacterial skin infections (HP:0005406)1.74459709
150Severe short stature (HP:0003510)1.74428424
151Petechiae (HP:0000967)1.74094915
152Cellulitis (HP:0100658)1.74045576
153Asymmetry of the thorax (HP:0001555)1.73737984
154Dislocated radial head (HP:0003083)1.73687852
155Gingivitis (HP:0000230)1.73449271
156Aneurysm (HP:0002617)1.73330309
157Abnormality of lateral ventricle (HP:0030047)1.73138132
158Myopathic facies (HP:0002058)1.72232058
159Chronic diarrhea (HP:0002028)1.71573901
160Myelodysplasia (HP:0002863)1.71548088
161T lymphocytopenia (HP:0005403)1.71078623
162Microvesicular hepatic steatosis (HP:0001414)1.71016598
163Mitral stenosis (HP:0001718)1.70527158
164Mucosal telangiectasiae (HP:0100579)1.70175208
165Interstitial pulmonary disease (HP:0006530)1.69252603
166Symptomatic seizures (HP:0011145)1.68638417
167Generalized amyotrophy (HP:0003700)1.68551363
168Slender long bone (HP:0003100)1.68264719
169Ankle contracture (HP:0006466)1.67528047
170Hyperglycinuria (HP:0003108)1.67110990
171Biconcave vertebral bodies (HP:0004586)1.66543660
172Lymphopenia (HP:0001888)1.66360904
173Hyperbilirubinemia (HP:0002904)1.65243055
174Mediastinal lymphadenopathy (HP:0100721)1.65240433
175Opisthotonus (HP:0002179)1.65222601
176Abnormality of nucleobase metabolism (HP:0010932)1.64934974
177Spinal rigidity (HP:0003306)1.63449569
178Cholelithiasis (HP:0001081)1.62490645
179Lymphangioma (HP:0100764)1.61307341
180Natal tooth (HP:0000695)1.61177778
181Flattened epiphyses (HP:0003071)1.61094672
182Elbow flexion contracture (HP:0002987)1.60731917
183Abnormality of the radial head (HP:0003995)1.59922851
184Aplasia/Hypoplasia of the clavicles (HP:0006710)1.58308433
185Self-mutilation (HP:0000742)1.58046689
186Complement deficiency (HP:0004431)1.57484767
187Abnormality of the gallbladder (HP:0005264)1.56774238

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT34.34189252
2ERN13.32460801
3TAOK33.32365270
4PIK3CG3.24174974
5PKN23.11010525
6TRIB32.98397434
7SMG12.94903648
8MAP4K12.88349528
9MAP3K102.72301308
10EIF2AK32.64625567
11IRAK32.41671429
12ACVR1B2.27056601
13KIT2.23053534
14TESK12.15071640
15EEF2K2.06610574
16CDK121.90573442
17MAP3K31.88881922
18PIM21.75319384
19CDK81.75031646
20MST1R1.72925078
21STK161.71212920
22IRAK41.70102083
23JAK31.67847691
24EPHB11.66109454
25NEK21.65716377
26ICK1.62031926
27BCKDK1.59575771
28NME21.58750215
29MAP3K111.52096836
30PASK1.47925371
31RPS6KA41.37268692
32TNK21.35880926
33ZAP701.32511942
34TYK21.30618295
35PTK61.29670135
36BUB11.26572792
37CSF1R1.25893533
38RIPK11.25818508
39SCYL21.22039621
40MAP3K141.17461872
41CDC42BPA1.14518515
42TSSK61.10233175
43ARAF1.09387431
44TBK11.07483752
45BTK1.05908822
46BLK1.05850501
47TAOK11.04906853
48CDK41.01763871
49CCNB11.01628629
50MAP2K30.97551388
51LMTK20.97502781
52KDR0.96727169
53WEE10.95641565
54MARK20.95578964
55SIK10.94488995
56JAK10.94458371
57TGFBR20.93757273
58ZAK0.93700580
59SYK0.92719258
60NLK0.91497825
61MARK30.90683740
62SIK20.89551189
63STK100.87333299
64RPS6KB20.84632555
65MTOR0.82886861
66ATR0.81069798
67DYRK30.80658022
68CDK70.78729641
69DYRK1B0.78615613
70NEK90.78487009
71PDGFRA0.78083562
72LRRK20.77475570
73FGFR40.76880746
74VRK20.76179977
75TXK0.75539926
76JAK20.74691624
77CDK190.72819852
78TAOK20.69968369
79PDK30.69640019
80PDK40.69640019
81MATK0.68809840
82CSK0.68384489
83TNIK0.66931179
84MAPKAPK30.66208889
85RPS6KA20.66032200
86MAP3K70.65128415
87FES0.64441812
88PLK40.63506512
89LCK0.62033705
90PRKCH0.61903074
91TESK20.61676202
92CAMK1D0.61434782
93PIM10.61208147
94TGFBR10.60111426
95RPS6KC10.58879507
96RPS6KL10.58879507
97LIMK10.58618911
98IRAK10.58233579
99BRSK20.57321963
100PTK20.56995317
101MAP3K10.55070067
102MAP3K60.54398602
103BRAF0.53290568
104SIK30.53064149
105TEC0.52909088
106HIPK20.52617807
107PDK10.52470720
108ABL20.52265897
109PDPK10.51667850
110BMX0.51282447
111FGR0.50668864
112DDR20.49032561
113MELK0.46902169
114HCK0.45138572
115IRAK20.44944873
116MAPKAPK20.43368275
117PRKD20.43340071
118MAPK110.42733525
119MAP2K20.42181973
120STK240.42152362
121MAPK40.41740558
122SRPK10.41034890
123PLK10.41034727
124MAPK70.39755182
125PRKD30.38326764
126CAMKK10.37668074
127GRK60.36975440
128KSR20.36583552
129IKBKB0.36446453
130LYN0.35997291
131MAP3K80.35933430
132EIF2AK20.35522226
133AURKB0.35401505
134IKBKE0.34312249
135VRK10.34028333
136CLK10.33784780
137MAPK150.33442312
138CDC70.32544661
139EPHA20.32337762
140RPS6KA60.31987978
141CDK60.31880178
142PAK40.31815377
143PIK3CA0.31260550
144CHUK0.31058958
145TTK0.30187139
146MYLK0.30117613
147PRPF4B0.29827920
148FRK0.29281803
149AURKA0.28482728
150TTN0.28270338
151DAPK10.28044361

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.60588597
2Protein export_Homo sapiens_hsa030603.25501770
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.94376858
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.81538085
5DNA replication_Homo sapiens_hsa030302.68772833
6Mismatch repair_Homo sapiens_hsa034302.55562079
7One carbon pool by folate_Homo sapiens_hsa006702.28439949
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27463526
9* N-Glycan biosynthesis_Homo sapiens_hsa005102.17719498
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.07818725
11Folate biosynthesis_Homo sapiens_hsa007902.07568767
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06286574
13Selenocompound metabolism_Homo sapiens_hsa004502.03827751
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.01691850
15Antigen processing and presentation_Homo sapiens_hsa046121.92584821
16Fructose and mannose metabolism_Homo sapiens_hsa000511.87968534
17Sulfur metabolism_Homo sapiens_hsa009201.79806531
18Other glycan degradation_Homo sapiens_hsa005111.76400647
19Notch signaling pathway_Homo sapiens_hsa043301.72097811
20Base excision repair_Homo sapiens_hsa034101.64833207
21Homologous recombination_Homo sapiens_hsa034401.64483996
22Pyrimidine metabolism_Homo sapiens_hsa002401.62438672
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.61230391
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.61224651
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.54197926
26Primary immunodeficiency_Homo sapiens_hsa053401.48421426
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29358241
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27479095
29Bladder cancer_Homo sapiens_hsa052191.26290482
30Sulfur relay system_Homo sapiens_hsa041221.25290539
31B cell receptor signaling pathway_Homo sapiens_hsa046621.21297697
32Pentose phosphate pathway_Homo sapiens_hsa000301.21210884
33Non-homologous end-joining_Homo sapiens_hsa034501.20724080
34Caffeine metabolism_Homo sapiens_hsa002321.18402768
35Biosynthesis of amino acids_Homo sapiens_hsa012301.15313775
36Non-small cell lung cancer_Homo sapiens_hsa052231.10824506
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.10540702
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08043014
39Carbon metabolism_Homo sapiens_hsa012001.07172843
40Lysine degradation_Homo sapiens_hsa003101.01849138
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.01128079
42Acute myeloid leukemia_Homo sapiens_hsa052210.99208893
43Complement and coagulation cascades_Homo sapiens_hsa046100.98579535
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98133145
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97992672
46Lysosome_Homo sapiens_hsa041420.97671860
47Nucleotide excision repair_Homo sapiens_hsa034200.97398896
48Tryptophan metabolism_Homo sapiens_hsa003800.95029212
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94769886
50Thyroid cancer_Homo sapiens_hsa052160.93402577
51Legionellosis_Homo sapiens_hsa051340.93399472
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92558403
53Galactose metabolism_Homo sapiens_hsa000520.92483117
54Cell cycle_Homo sapiens_hsa041100.92151036
55Shigellosis_Homo sapiens_hsa051310.91968448
56Fatty acid degradation_Homo sapiens_hsa000710.91664622
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91524597
58Fatty acid elongation_Homo sapiens_hsa000620.91115730
59Measles_Homo sapiens_hsa051620.90098142
60Vitamin B6 metabolism_Homo sapiens_hsa007500.85818365
61Hepatitis C_Homo sapiens_hsa051600.85257366
62Fanconi anemia pathway_Homo sapiens_hsa034600.84044574
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83883951
64Pyruvate metabolism_Homo sapiens_hsa006200.83519313
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82491957
66Vibrio cholerae infection_Homo sapiens_hsa051100.81973382
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80702571
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79075577
69Herpes simplex infection_Homo sapiens_hsa051680.78883211
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78030407
71Insulin resistance_Homo sapiens_hsa049310.77031984
72Glutathione metabolism_Homo sapiens_hsa004800.76922885
73Vitamin digestion and absorption_Homo sapiens_hsa049770.76142019
74RNA transport_Homo sapiens_hsa030130.75528911
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74008907
76VEGF signaling pathway_Homo sapiens_hsa043700.73143462
77Endometrial cancer_Homo sapiens_hsa052130.73062921
78Inositol phosphate metabolism_Homo sapiens_hsa005620.72057830
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.71209593
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70301381
81Proteasome_Homo sapiens_hsa030500.67997860
82Regulation of autophagy_Homo sapiens_hsa041400.67007028
83Purine metabolism_Homo sapiens_hsa002300.66972939
84TNF signaling pathway_Homo sapiens_hsa046680.66558979
85Peroxisome_Homo sapiens_hsa041460.66517348
86Epstein-Barr virus infection_Homo sapiens_hsa051690.65954298
87Fatty acid metabolism_Homo sapiens_hsa012120.65412532
88Toxoplasmosis_Homo sapiens_hsa051450.65093568
89Sphingolipid metabolism_Homo sapiens_hsa006000.64411890
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.63884263
91Prostate cancer_Homo sapiens_hsa052150.62181894
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60927773
93ABC transporters_Homo sapiens_hsa020100.60619212
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60482582
95Influenza A_Homo sapiens_hsa051640.60046193
96p53 signaling pathway_Homo sapiens_hsa041150.59659077
97Prion diseases_Homo sapiens_hsa050200.59632163
98Tyrosine metabolism_Homo sapiens_hsa003500.58897436
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57565420
100Insulin signaling pathway_Homo sapiens_hsa049100.56942577
101Hepatitis B_Homo sapiens_hsa051610.56870931
102Renin-angiotensin system_Homo sapiens_hsa046140.56800898
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55693581
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55333149
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.55211816
106Staphylococcus aureus infection_Homo sapiens_hsa051500.54490837
107Starch and sucrose metabolism_Homo sapiens_hsa005000.54208457
108AMPK signaling pathway_Homo sapiens_hsa041520.53849477
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53209369
110RNA polymerase_Homo sapiens_hsa030200.53049937
111Leishmaniasis_Homo sapiens_hsa051400.52513655
112Arginine biosynthesis_Homo sapiens_hsa002200.52377674
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.52307243
114Apoptosis_Homo sapiens_hsa042100.50833539
115Hematopoietic cell lineage_Homo sapiens_hsa046400.50585994
116Colorectal cancer_Homo sapiens_hsa052100.49831327
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.49391391
118Osteoclast differentiation_Homo sapiens_hsa043800.49211292
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.48886001
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47580999
121mTOR signaling pathway_Homo sapiens_hsa041500.47098575
122Chronic myeloid leukemia_Homo sapiens_hsa052200.47059606
123HTLV-I infection_Homo sapiens_hsa051660.46787451
124Prolactin signaling pathway_Homo sapiens_hsa049170.46472606
125Endocytosis_Homo sapiens_hsa041440.46358665
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45645138
127Pertussis_Homo sapiens_hsa051330.44885198
128Arginine and proline metabolism_Homo sapiens_hsa003300.44842525
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44322300
130beta-Alanine metabolism_Homo sapiens_hsa004100.43880850
131Viral carcinogenesis_Homo sapiens_hsa052030.43816637
132Pancreatic cancer_Homo sapiens_hsa052120.43393693
133Phenylalanine metabolism_Homo sapiens_hsa003600.42185180
134RNA degradation_Homo sapiens_hsa030180.41652653
135Small cell lung cancer_Homo sapiens_hsa052220.41519296
136Propanoate metabolism_Homo sapiens_hsa006400.40050127
137Steroid biosynthesis_Homo sapiens_hsa001000.37359422
138HIF-1 signaling pathway_Homo sapiens_hsa040660.36507120

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